JP6489018B2 - Rehabilitation support system and brain function measurement device - Google Patents

Description

  The present invention relates to a rehabilitation support system and a brain function measurement device, and more particularly to a rehabilitation support system and a brain function measurement device that support rehabilitation of a subject with a brain function disorder.

  Conventionally, a rehabilitation support system that supports rehabilitation of a subject with brain dysfunction is known. Such a rehabilitation support system is disclosed in, for example, Japanese Patent Application Laid-Open No. 2006-263460.

  The rehabilitation support system disclosed in Japanese Patent Application Laid-Open No. 2006-263460 includes a brain function measuring device that measures a brain activity of a subject during rehabilitation, an analysis device, and a display device. I have. This system measures brain activity when a subject tries to perform rehabilitation exercises at a site where paralysis has occurred due to brain damage. This system was able to analyze whether or not a rehabilitation motion command was obtained as a brain activity from the brain activity measurement results (whether or not motor recall was possible) and to be able to recall the motor. Is displayed on the display device. The display device displays the measurement data of the brain function measurement device as it is in addition to the result of the motion recall.

JP 2006-263460 A

  However, in the configuration that displays the result of exercise recall during rehabilitation as in JP-A-2006-263460, it is only possible to grasp the success or failure of each rehabilitation exercise operation, and the daily brain function changes The degree of recovery by rehabilitation cannot be grasped objectively. In addition, when displaying brain function measurement data as they are, patients (subjects) themselves and healthcare professionals with limited expertise other than cranial nerve specialists cannot read changes in brain function from the displayed content (measurement data). Have difficulty. For this reason, the above Japanese Patent Application Laid-Open No. 2006-263460 has a problem that it is difficult for those who lack technical knowledge to objectively grasp the degree of recovery of brain function (change in brain function) by rehabilitation. .

  The present invention has been made to solve the above-described problems, and one object of the present invention is a rehabilitation support system capable of easily and objectively grasping the degree of recovery of brain function by rehabilitation. And a brain function measuring device.

In order to achieve the above object, a rehabilitation support system according to a first aspect of the present invention is a system that supports rehabilitation of a subject with brain dysfunction, and measures a brain activity of the subject during rehabilitation. Based on the brain function measurement device and the measurement result of the subject's brain activity in rehabilitation, information indicating a pattern different from that of a healthy person peculiar to a subject having brain dysfunction is used as an index indicating the degree of recovery of the brain function of the subject. And a control device that performs control to display the acquired index on the display device. In addition, the rehabilitation of a subject with brain dysfunction in the present invention is cerebral dysfunction classified into mental disorders such as depression and schizophrenia, in addition to brain dysfunction with brain damage such as stroke and cerebral infarction. It is a broad concept including rehabilitation.

The rehabilitation supporting system according to a first aspect of the invention, as described above, based on the measurement result of the brain activity of the subject in rehabilitation, as an index indicating the degree of recovery subject's brain function, a subject with brain dysfunction By obtaining a control device that controls the display of the acquired index on a display device while acquiring information representing a pattern different from that of a specific healthy person, an index indicating the degree of recovery of the brain function of the subject (user or subject) Medical professionals). Thereby, even when the user does not have specialized knowledge for understanding the brain function measurement result data itself, the user can easily and objectively grasp the degree of recovery of the brain function by the rehabilitation. In addition, since medical staff can easily grasp whether or not brain function changes have occurred by using an index, this index should be used as a measure of rehabilitation such as the daily condition of the subject and the degree of rehabilitation. Can do. And even if the subject (patient) has little change (improvement) in the visible movement such as the movement of the paralyzed part, it can be seen that the index has the effect of rehabilitation, and it can be expected to improve the motivation to rehabilitation, As a result, an improvement in the rehabilitation effect can also be expected. In addition, when subjects with brain dysfunction (and movement disorders associated with cerebral dysfunction) recover by rehabilitation, they exhibit specific brain activity different from that of healthy individuals at the beginning of the onset, while healthy with recovery Often approaches the person's brain activity. Therefore, by using an index indicating a change in brain function according to a brain dysfunction, it is possible to objectively grasp the degree of recovery of brain function from the difference from the index of a healthy person.

  In the rehabilitation support system according to the first aspect described above, preferably, the brain function measuring device is configured to measure the brain activity of the subject during or after the rehabilitation, and the control device regularly An index is acquired and displayed based on the measurement result. If comprised in this way, since the parameter | index which shows the recovery | restoration degree of a brain function can be regularly shown to a user based on the measurement result of the test subject's brain activity for every rehabilitation, it accompanies progress of rehabilitation over a long period of time. The degree of recovery of brain function (change in brain function) can be grasped continuously.

  In the rehabilitation support system according to the first aspect, preferably, the rehabilitation support system further includes a storage unit that stores the acquired index, and the control device displays the index acquired this time together with the past index stored in the storage unit on the display device. Is configured to do. If comprised in this way, the change of a time-sequential parameter | index accompanying progress of rehabilitation over a long term can be shown to a user. Thereby, the user can grasp | ascertain the recovery tendency of the brain function accompanying the continuation of rehabilitation.

In this case, it is preferable that the control device displays the past index stored in the storage unit and the index acquired this time in a time-series graph format with an index indicating the elapsed time and the recovery degree of brain function as each axis. It is comprised so that it may display on a display apparatus. If comprised in this way, a user can grasp | ascertain easily the change of the parameter | index from the past to the present at a glance. Thereby, the change of the recovery | restoration degree of the brain function by rehabilitation can be grasped | ascertained more easily. Moreover, since the test subject (patient) can recognize the result of the rehabilitation continuously performed over a long period of time based on the chronological change of the index, improvement in motivation to rehabilitation can be expected.

  In the rehabilitation support system according to the first aspect, preferably, the index indicating the recovery degree of the brain function of the subject is an index indicating a change in brain function according to the brain function disorder of the subject. Here, when subjects with brain dysfunction (and movement disorders associated with cerebral dysfunction) recover by rehabilitation, they exhibit distinctive brain activity different from that of healthy individuals at the beginning of the onset. Often approaches the brain activity of healthy people. Therefore, by using an index indicating a change in brain function according to a brain dysfunction, it is possible to objectively grasp the degree of recovery of brain function from the difference from the index of a healthy person.

In the rehabilitation support system according to the first aspect , preferably, the rehabilitation is an exercise recovery rehabilitation of a partially paralyzed patient associated with a brain disorder, and the index indicating the degree of recovery of the brain function of the subject indicates a left-right difference in brain function. A side index. If comprised in this way, the recovery | restoration degree of a brain function can be objectively evaluated using the lateralization index | exponent which shows the left-right difference of a brain function. That is, in the normal person, the brain function of the action side and the contralateral side becomes dominant by crossover, whereas in the case of hemiplegia, the function that the paralyzed region and the contralateral brain region originally have are As a result of the activity of the ipsilateral brain area supplementing, the ipsilateral brain function is relatively superior to the healthy subject. Then, this ipsilateral dominant brain activity approaches the brain activity of a normal person with contralateral superiority as the function is restored by rehabilitation. For this reason, it is possible to objectively evaluate the degree of recovery of brain function by rehabilitation by knowing which side of the other side is dominant by the side index.

In the rehabilitation support system according to the first aspect, preferably, the index indicating the recovery degree of the brain function of the subject is a brain function in a region where brain function activation patterns are different between a brain function impaired person and a healthy person. Or the area of the brain area where the brain activity changes in areas where the brain function activation pattern differs between a person with a brain dysfunction and a healthy person that exceeds a predetermined threshold. The control device is configured to display numerical data as an index indicating the recovery degree of the brain function of the subject and a display indicating evaluation of the numerical data on the display device. With this configuration, in addition to an index (numerical data) indicating the degree of recovery of the brain function of the subject, a display indicating the evaluation of the numerical data further facilitates the recovery of brain function even for users with limited expertise. The degree can be grasped.

  In this case, preferably, when the numerical data as an index indicating the degree of recovery of the brain function of the subject indicates an improvement in the brain function, the control device displays a sentence that gives up or encourages the subject as a display indicating the evaluation of the numerical data. Is configured to do. If comprised in this way, the motivation to rehabilitation will increase by showing to a test subject the sentence which compliments or encourages a patient (test subject) with a numerical data, As a result, it can anticipate improving the rehabilitation effect more.

  In the configuration in which the control device periodically displays an index based on the measurement result of the brain function measuring device, preferably, the brain function measuring device is configured to measure the brain activity of the subject for each daily rehabilitation and control. The apparatus is configured to acquire and display an index based on the measurement result of the brain function measurement apparatus of the day as a result of the daily rehabilitation. If comprised in this way, the user can confirm a parameter | index as a result of daily rehabilitation, and can grasp | ascertain more objectively the change of the daily brain function (rehabilitation success).

A brain function measuring apparatus according to a second aspect of the present invention is a brain function measuring apparatus used for rehabilitation of a subject with a brain dysfunction, and includes a detection terminal unit that detects a signal indicating brain activity of the subject, and a detection terminal Brain function as an index indicating the degree of recovery of the brain function of the subject based on the measurement result of the brain activity of the subject based on the measurement result of the brain activity of the subject in the rehabilitation A control unit that acquires information representing a pattern different from that of a healthy person peculiar to a subject having a disability and performs control to display the acquired index on a display unit.

In the brain function measuring apparatus according to the second aspect of the present invention, as described above , the subject having a brain function disorder as an index indicating the degree of recovery of the subject's brain function based on the measurement result of the subject's brain activity in the rehabilitation. By acquiring a control unit that controls the display of the acquired index on the display unit while acquiring information representing a pattern different from that of a healthy person peculiar to the user, an index indicating the degree of recovery of the brain function of the subject is obtained by the user (subject Or medical staff). Thereby, even when the user does not have specialized knowledge for understanding the brain function measurement result data itself, the user can easily and objectively grasp the degree of recovery of the brain function by the rehabilitation. In addition, the medical staff can use this index as a measure of rehabilitation such as the daily condition of the subject and the degree of rehabilitation. And a test subject (patient) understands that there exists a rehabilitation effect with an index, and can expect improvement in motivation to rehabilitation and improvement in rehabilitation effect. In addition, when subjects with brain dysfunction (and movement disorders associated with cerebral dysfunction) recover by rehabilitation, they exhibit specific brain activity different from that of healthy individuals at the beginning of the onset, while healthy with recovery Often approaches the person's brain activity. Therefore, by using an index indicating a change in brain function according to a brain dysfunction, it is possible to objectively grasp the degree of recovery of brain function from the difference from the index of a healthy person.

  As described above, according to the present invention, it is possible to easily and objectively grasp the degree of recovery of brain function by rehabilitation.

It is a mimetic diagram showing the whole rehabilitation support system composition by a 1st embodiment of the present invention. It is a block diagram which shows the structure of the brain function measuring device of the rehabilitation assistance system by 1st Embodiment of this invention. It is a schematic diagram for demonstrating a side index. It is a figure which shows an example of the display mode of a display apparatus. It is a flowchart for demonstrating operation | movement of the rehabilitation assistance system by 1st Embodiment of this invention. It is a schematic diagram for demonstrating the brain function measuring apparatus by 2nd Embodiment of this invention.

  Hereinafter, embodiments will be described with reference to the drawings.

(First embodiment)
First, with reference to FIGS. 1-4, the whole structure of the rehabilitation assistance system (henceforth a rehabilitation assistance system) 100 by 1st Embodiment of this invention is demonstrated. The rehabilitation support system 100 is a system that supports rehabilitation of a subject (patient) with a brain function disorder. In the first embodiment, as an example of rehabilitation, an example of motor function recovery rehabilitation of a partially paralyzed patient associated with a brain disorder such as stroke will be described.

  As shown in FIG. 1, the rehabilitation support system 100 according to the first embodiment is mainly configured by a brain function measuring device 1, a display device 2, a body driving device 3, and a control device 4.

  As the rehabilitation, the subject (patient) is caused to perform a rehabilitation exercise of the paralyzed part set in advance according to the paralyzed part. The rehabilitation exercise is an exercise for opening and closing the hand with respect to the paralyzed hand, for example, when the paralyzed site is a hand. In this case, even if the subject tries to open and close the hand, the hand cannot be moved due to paralysis. The rehabilitation support system 100 performs brain function measurement during rehabilitation, analyzes the measurement result, and performs motor recall corresponding to the rehabilitation motion of the paralyzed site (rehabilitating motion from the brain by concretely imaging the motion). It is determined whether or not an order can be issued. When the motion recall is made, the rehabilitation support system 100 forcibly moves the paralyzed hand with an external force and actually causes the rehabilitation motion. In rehabilitation, this operation is repeated a predetermined number of times. In the rehabilitation, one set to several sets per day are continuously performed over a period of several months, with the predetermined number of exercise recalls and exercises as one set.

  As shown in FIG. 1, the brain function measuring device 1 is a device that non-invasively measures the brain activity of a subject in rehabilitation, and detects an optical signal associated with optical measurement and brain activity using near infrared spectroscopy (NIRS). It has a function to measure brain waves. That is, the brain function measuring device 1 functions as both a NIRS device (optical measuring device) and an EEG device (electroencephalograph). In 1st Embodiment, the brain function measuring apparatus 1 is comprised so that the test subject's brain activity in rehabilitation may be measured for every daily rehabilitation.

  As shown in FIG. 2, the brain function measuring apparatus 1 includes a main body 10, a plurality of optical probes 5 a and 5 b for optical measurement connected to the main body 10, and a plurality of electroencephalographic electrode probes 6. It has. The main body unit 10 is provided with a light output unit 11, a light detection unit 12, an electroencephalogram detection unit 13, a measurement control unit 14, a main body control unit 15, and a main storage unit 16. In addition, the brain function measuring apparatus 1 includes a display unit 17 and an operation input unit 18 (such as a keyboard) that are installed on the main unit 10 and connected to the main unit 10.

  The optical probes 5a and 5b and the electrode probe 6 have a function of detecting a signal indicating the brain activity of the subject. The brain function measurement apparatus 1 irradiates measurement light in the wavelength region of near-infrared light from an optical probe 5a for light transmission disposed on the head surface of the subject and reflects the measurement light reflected in the subject's head on the head surface. The intensity (the amount of received light) of the measurement light is acquired by making it incident on the light receiving optical probe 5b disposed above and detecting it. Based on the intensity of the measurement light, it is possible to obtain changes in the amount of hemoglobin (oxygenated hemoglobin, deoxygenated globin and total hemoglobin) associated with brain activity. Thereby, it is possible to acquire non-invasively the change of the amount of hemoglobin accompanying brain activity, ie, the change of blood flow, and the activation state of oxygen metabolism. In optical measurement, brain activity is measured for each measurement point (channel) constituted by a pair of optical probes 5a and 5b.

  The electrode probe 6 detects weak electrical activity (electroencephalogram) generated with brain activity by an electrode arranged on the subject's head surface. A plurality of these optical probes 5a, 5b and electrode probes 6 are provided in order to widely measure the brain activity of each part of the brain region. Each probe measures brain function while being held by a holder 7 attached to the head of the subject. Each probe is generally arranged in accordance with the International 10-20 method shown in FIG. 3, and the probe is arranged according to the measurement purpose such as an arrangement centering on C3 and C4 corresponding to the primary motor area that controls the motor function. It is set to be a distribution.

  As shown in FIG. 2, the light output unit 11 includes a semiconductor laser as a light source, and outputs measurement light to an optical probe 5a for light transmission via an optical fiber. The light detection unit 12 includes a photomultiplier tube as a detector, and acquires and detects measurement light incident on the light receiving optical probe 5b via an optical fiber. The electroencephalogram detection unit 13 acquires an electrical signal detected from the electrode probe 6. The measurement control unit 14 performs operation control (lighting and extinguishing and detection) of the light output unit 11 and the light detection unit 12 and control of the electroencephalogram detection unit 13 according to the measurement conditions set by the main body control unit 15. The light output unit 11, the light detection unit 12, the brain wave detection unit 13, and the measurement control unit 14 constitute a measurement unit 19 that acquires the detection signals of the probes and measures the brain activity of the subject.

  The main body control unit 15 is a computer (PC) configured by a CPU, a memory, and the like, and executes measurement operation control of the brain function measuring device 1 by executing a measurement control program stored in the main storage unit 16. Functions as a control unit. The main body control unit 15 performs various processes such as measurement start and measurement stop control, measurement condition setting, and measurement data storage. In addition, the main body control unit 15 performs mutual communication with the control device 4 via a communication unit (not shown) including a wired or wireless communication module. The main storage unit 16 is composed of, for example, an HDD (hard disk drive), and can store various programs executed by the main body control unit 15 and store measurement data obtained as a result of measurement.

  As shown in FIG. 1, the display device 2 is a liquid crystal display, for example, and performs video display based on a signal output from the control device 4. The body drive device 3 forcibly (passively) executes the movement of the rehabilitation target part by applying an external force using the drive unit 31 such as a motor. The body drive device 3 is prepared according to the target site, but the body drive device 3 used for opening and closing movements of the paralyzed hand is mounted on the paralyzed hand of the subject, for example, and is driven to a portion corresponding to the joint of the finger. Part 31 is arranged. And the body drive device 3 opens and closes a paralyzed hand compulsorily (dynamically) by rotating the front end side of a finger with respect to the base side by the drive part 31. FIG. The body driving device 3 is driven and controlled by a control signal from the control device 4.

  The control device 4 is connected to the brain function measuring device 1, the display device 2, and the body driving device 3, and has a function of controlling these devices. The control device 4 is a computer (PC) including an arithmetic processing unit 41 including a CPU and a memory and a storage unit 42 including an HDD, and the analysis / display control program stored in the storage unit 42 By executing this, it functions as a control device that analyzes measurement result data and controls each device. During the rehabilitation, the control device 4 acquires a brain function measurement result (electroencephalogram measurement data) using the electrode probe 6 and performs data analysis to determine whether or not data indicating motor recall has been obtained. It has a function. In addition, when the motion recall is successful, the control device 4 outputs a control signal (drive command) to the body drive device 3 to control the drive operation, and displays a display indicating that the motion recall is successful. It is configured to be displayed.

  Here, in 1st Embodiment, the control apparatus 4 acquires the parameter | index which shows the recovery degree of a test subject's brain function based on the measurement result of the test subject's brain activity in rehabilitation, and displays the acquired parameter | index on the display apparatus 2. FIG. It is configured to perform control.

  In the first embodiment, the index indicating the degree of recovery of the brain function of the subject is an index indicating the change in the brain function according to the brain function disorder of the subject, and more specifically, the side indicating the left-right difference in the brain function It is a conversion index LI (Lateralization Index). The control device 4 calculates the side index LI based on the brain function measurement result (optical measurement data) during rehabilitation using the optical probes 5a and 5b.

The side index LI is calculated by the following equation (1).
LI = (C−I) / (C + I) (1)
Here, C is the brain activity change (NIRS signal, oxygenated hemoglobin change) of the lesion (paralysis site) and the contralateral motor cortex. I is the brain activity change (NIRS signal, oxygenated hemoglobin change) of the motor area on the same side as the lesion (paralysis site). The brain activity change is a difference (hemoglobin change amount) between detection signals during rest (rest period) during rehabilitation and activity (task period) by motor recall.

  As can be seen from the above equation (1), the side index LI is a ratio value and takes a value in the range of −1 to +1. As I increases and the lateralization index LI approaches −1 (takes a negative value), the brain activity on the same side as the paralysis site (motion site) is more dominant, C increases, and LI approaches +1 (positive) It shows that the paralysis part (motion part) and the contralateral brain activity are more dominant. When LI is 0, the brain activity is substantially symmetric (equivalent) between I (same side) and C (opposite side).

  As shown in FIG. 3, generally, the motor function of the body is controlled by the opposite motor area by crossover. Therefore, in a healthy person, the brain activity on the movement site (for example, the left hand) and the contralateral side (the motor area on the right side) is dominant. For this reason, for example, when hemiplegia occurs on the left side due to a stroke or the like, the brain function of the paralyzed site (left hand) and the contralateral side (motor field of the right hemisphere) is impaired. In such a case, when the brain function of the subject is measured, the brain on the same side (left side) as the paralyzed site so as to compensate for the function of the brain region (right motor area) opposite to the paralyzed site (left hand). It is known that brain activity is measured in a wide range including a brain region that is not actively involved in a healthy person while the region is more active. As a result, when hemiplegia occurs, although there are differences depending on individual differences and severity, the brain function on the same side (left side) is relatively superior to that of healthy individuals, especially for a while after the onset ( The side index LI approaches -1 (negative)).

  Then, with the recovery of motor function (recovery of brain function) by rehabilitation, the ipsilateral dominant brain activity in this wide range changes. Specifically, with the recovery of brain function, the brain activity approaches the same brain activity as that of a healthy person with a contralateral (right side) advantage, and the activity range of the brain region gradually narrows to limit the activity region. That is, when rehabilitation is continued, the side index LI changes in a direction approaching +1 (positive) as it recovers.

  Therefore, based on whether the ipsilateral (negative) or contralateral (positive) brain function is superior by the lateralization index LI, the lateralization index LI immediately after onset approaches the contralateral superiority (positive). It can be evaluated that there is a tendency to improve brain function by rehabilitation when showing a changing tendency. In addition, the degree of recovery of brain function by rehabilitation can be evaluated by comparing the current lateralized index LI with the range that can be taken by the normal healthy person's lateralized index LI. Accordingly, the lateralization index LI can be used as a guideline for objectively grasping the degree of recovery of brain function by rehabilitation.

  In the first embodiment, the control device 4 is configured to periodically calculate and display an index (side index LI). Specifically, the control device 4 calculates and displays an index (side index LI) based on the measurement result of the brain function measurement device 1 of the day as a result of the daily rehabilitation. In addition, the control device 4 accumulates and stores the calculated index (side index LI) in the storage unit 42. When displaying the index (side index LI), the control device 4 displays the index (side index LI) calculated this time along with the past index (side index LI) stored in the storage unit 42 in time series. It is configured to display in graph format.

  FIG. 4 shows an example of the display mode. In this display example, the side index LI is displayed as “rehabilitation index”. As shown in FIG. 4, the control device 4 displays a graph 51 of numerical data (LI) indicating a change in an index (side index LI) from the onset (October) to this time, and a display indicating evaluation of the numerical data ( The message unit 52) is displayed on the display device 2. In this display example, on the right side of the graph 51, the LI range and the average value generally found in healthy persons are displayed as reference values.

  As shown in the graph 51 of FIG. 4, in a typical case where rehabilitation shows an effect, LI is biased to the same side (negative) for a while from the onset (October), and rehabilitation continues (function recovery). At the same time, LI gradually changes to the opposite side (positive). Therefore, the control device 4 gives up or encourages the subject when the side index LI as an index indicating the degree of recovery of the brain function of the subject indicates improvement in the brain function (they tend to change in the + direction) ( “Today's rehabilitation was very good”, etc.) is displayed on the message section 52. However, the values of the lateralization index LI (measured values and reference values of the subject) shown in FIG. 4 are plotted for convenience in order to explain the display mode of the display device 2, and are based on actual measurement data. It is not a thing.

  Next, an operation during rehabilitation of the rehabilitation support system 100 according to the first embodiment will be described with reference to FIG. In order to facilitate understanding, in part (step S1), the operation steps on the patient side other than the rehabilitation support system 100 are described.

  First, in step S1 of FIG. 5, a patient (subject) performs exercise recall that opens and closes a paralyzed hand. In step S2, brain function measurement (electroencephalogram measurement) by the brain function measuring apparatus 1 is performed. Specifically, the brain function measuring device 1 performs brain function measurement using the electrode probe 6 and outputs the obtained brain function measurement result (electroencephalogram measurement data) to the control device 4.

  Next, in step S3, the control device 4 analyzes the brain function measurement result (electroencephalogram measurement data) and determines the presence or absence of the motion recall. When it is determined that there is a motion recall, the control device 4 drives the body drive device 3 to perform a rehabilitation exercise (opening and closing of the hand) and displays on the display device 2 that the motion recall has been completed in step S4. Let

  On the other hand, if it is determined in step S3 that there is no motion recall, the control device 4 proceeds to step S5 and displays on the display device 2 that motion recall has not been performed. Note that, for example, nothing may be displayed on the display device 2 instead of displaying that the exercise is not recalled.

  Subsequently, in step S6, brain function measurement (optical measurement) is performed by the brain function measuring apparatus 1. Specifically, the brain function measuring device 1 performs brain function measurement using the optical probes 5 a and 5 b, and outputs the obtained brain function measurement result (light measurement data) to the control device 4.

  In step S7, the control device 4 determines whether or not the rehabilitation training is finished. That is, it is determined whether or not the above steps S1 to S6 are repeated a predetermined number of times (or a predetermined time). If the rehabilitation training has not ended, the process returns to step S1. When the rehabilitation training is finished, the process proceeds to step S8.

  In step S8, the control device 4 calculates and displays the index (side index LI). That is, the control device 4 calculates the side index LI by the above formula (1) based on the brain function measurement result (optical measurement data) acquired in step S6. The control device 4 displays the calculated side index LI on the display device 2 in the graph format (graph 51) shown in FIG. 4 together with the past index (side index LI) stored in the storage unit 42. To do. In this case, since the measurement data for the number of rehabilitation exercises is obtained, the side index LI for each time may be displayed as a finer time change, for example, the obtained predetermined number of times side An average value of the conversion index LI may be displayed. Further, the control device 4 displays a message indicating the evaluation of the calculated side index LI on the message unit 52.

  As described above, the operation of the rehabilitation support system 100 according to the first embodiment is performed. This operation is performed, for example, as a one-day rehabilitation, and a graph 51 over a long period of time as shown in FIG. 4 is obtained by accumulating daily rehabilitation results.

  In the first embodiment, the following effects can be obtained.

  In 1st Embodiment, while acquiring the parameter | index (LI) which shows the recovery degree of a test subject's brain function based on the measurement result of the test subject's brain activity in rehabilitation as mentioned above, the acquired parameter | index (LI) is displayed. By providing the control device 4 that performs control to be displayed in 2, an index (LI) indicating the recovery degree of the brain function of the subject based on the measurement result of the brain activity of the subject in rehabilitation is given to the user (subject or medical worker, etc.) Can be presented. Thereby, even when the user does not have specialized knowledge for understanding the brain function measurement result data itself, the user can easily and objectively grasp the recovery degree of the brain function by the rehabilitation by the index (LI). Can do. In addition, since a medical worker can easily grasp whether or not a change in brain function has occurred with an index (LI), this index (LI) can be used to determine the daily condition of the subject and the degree of rehabilitation. It can be used as a guide for rehabilitation. Furthermore, subjects (patients) are able to understand that the index (LI) is effective for rehabilitation even when there is little change (improvement) in the visible movements such as the movement of the paralyzed part, and the improvement of motivation for rehabilitation is expected. In addition, it can be expected to improve the rehabilitation effect as a result.

  Moreover, in 1st Embodiment, as mentioned above, the brain function measuring apparatus 1 is comprised so that a test subject's brain activity may be measured during rehabilitation. Then, the control device 4 is configured to periodically acquire and display an index (LI) based on the measurement result of the brain function measuring device 1. Thereby, since the index (LI) which shows the recovery | restoration degree of a brain function can be regularly shown to a user based on the measurement result of the test subject's brain activity for every rehabilitation, the brain accompanying progress of rehabilitation over a long period of time. The degree of recovery of function (change in brain function) can be grasped continuously.

  In the first embodiment, as described above, the control device 4 is configured to display the index (LI) acquired this time together with the past index (LI) stored in the storage unit 42. Thereby, the change of the time-sequential parameter | index (LI) accompanying progress of rehabilitation over a long period of time can be shown to a user. As a result, the user can grasp the recovery tendency of the brain function accompanying the continuation of the rehabilitation based on the change of the index (LI).

  In the first embodiment, as described above, the past index (LI) stored in the storage unit 42 and the index (LI) acquired this time are displayed in a time-series graph format (graph 51). The control device 4 is configured as described above. Accordingly, since the user can easily grasp the change in the index (LI) from the past to the present at a glance, it is possible to more easily grasp the change in the degree of recovery of brain function due to rehabilitation. Moreover, since the test subject (patient) can recognize the result of the rehabilitation continuously performed over a long period of time by the time-series change of the index (LI), it can be expected to improve the motivation to the rehabilitation.

  In the first embodiment, as described above, an index (LI) indicating a change in brain function according to the brain function disorder of the subject is used as an index indicating the degree of recovery of the brain function of the subject. In the case where a subject who has suffered from hemiplegia associated with cerebral dysfunction described in the first embodiment is recovered by rehabilitation, unique brain activity (ipsilateral dominant brain activity) that is different from that of a healthy person in the early stage of onset On the other hand, it often approaches the brain activity of the healthy person (the brain activity of the contralateral superiority) with the recovery. Therefore, by using an index (LI) indicating a change in brain function in response to a brain dysfunction, the degree of recovery of brain function can be objectively grasped from the difference from the healthy person index (LI).

  In the first embodiment, as described above, the rehabilitation is a movement recovery rehabilitation of a partially paralyzed patient associated with a cerebral disorder, and indicates a difference between left and right brain functions as an index indicating a degree of recovery of the brain function of the subject. The conversion index LI is used. As a result, it is possible to know which side of the same side or the other side is predominately active by the lateralization index LI indicating the left-right difference in brain function (difference from the brain function of the other side of the healthy subject). The degree of recovery can be objectively evaluated.

  In the first embodiment, as described above, the numerical data (LI) as an index indicating the recovery degree of the brain function of the subject and the display (message unit 52) indicating the evaluation of the numerical data (LI) are displayed. Thus, the control device 4 is configured. Thereby, in addition to the numerical data (LI) indicating the degree of recovery of the brain function of the subject, the display of the message unit 52 indicating the evaluation of the numerical data further facilitates the recovery of the brain function even by a user with limited expertise. The degree can be grasped.

In the first embodiment, as described above, when the lateralization index LI indicates an improvement in brain function, a sentence that gives up or encourages the subject is displayed on the message unit 52 indicating the evaluation of the lateralization index LI. The control device 4 is configured. Thus, by presenting to the subject a sentence that compliments or encourages the patient (subject) together with the side index LI, motivation for rehabilitation increases, and as a result, it can be expected to improve the rehabilitation effect. It has been reported in the following literature that the rehabilitation effect has been improved by giving up or encouraging patients in rehabilitation.
International Randomized Clinical Trial, Stroke Independent Rehabilitation With Rewiring of Walking Speed (SIRROWS), Improves Outcomes: Neurorehab. 2010 Mar-Apr; 24 (3): 235-42

  Moreover, in 1st Embodiment, as mentioned above, the brain function measuring apparatus 1 is comprised so that a test subject's brain activity may be measured for every daily rehabilitation. And the control apparatus 4 is comprised so that the parameter | index (LI) based on the measurement result of the brain function measuring apparatus 1 of the day may be displayed as a result of the rehabilitation of the day. As a result, the user can check the index (LI) as the daily rehabilitation result, and can more objectively grasp the daily brain function change (performance of rehabilitation).

(Second Embodiment)
Next, a brain function measuring apparatus 101 according to a second embodiment of the present invention will be described with reference to FIG. 1, FIG. 2, FIG. 5, and FIG. In the second embodiment, unlike the first embodiment in which the rehabilitation support system 100 is configured to calculate the index (LI) by the control device 4 and display the calculated index (LI) on the display device 2, An example of a brain function measuring apparatus that calculates and displays an index (LI) alone will be described.

  As shown in FIG. 6, the brain function measuring apparatus 101 according to the second embodiment is used for the rehabilitation of a subject with a brain function disorder, as in the first embodiment. The device configuration (hardware configuration) of the brain function measuring device 101 is the same as that of the brain function measuring device 1 of the first embodiment shown in FIG. That is, the brain function measuring apparatus 101 includes a plurality of optical probes 5a and 5b and electrode probes 6 that detect signals indicating the brain activity of the subject. In addition, the brain function measuring apparatus 101 includes a measuring unit 19 (light output unit 11, light detecting unit 12, electroencephalogram detecting unit 13 and measurement control unit 14) that acquires the detection signals of the probes and measures the brain activity of the subject. And a display unit 17. In FIG. 6, the light output unit 11, the light detection unit 12, the electroencephalogram detection unit 13, and the measurement control unit 14 are collectively illustrated as a measurement unit 19. Each of the optical probes 5a and 5b and the electrode probe 6 is an example of the “detection terminal portion” in the present invention.

  In the second embodiment, the main body control unit 115 of the brain function measuring apparatus 101 not only performs the measurement operation control of the brain function measuring apparatus 101 but also executes the same control process as the control apparatus 4 in the first embodiment. It is configured as follows. That is, the main body control unit 115 calculates an index (side index LI) indicating the recovery degree of the brain function of the subject based on the measurement result of the brain activity of the subject in the rehabilitation, and acquires the acquired index (side index LI). Is displayed on the display unit 17. In the second embodiment, the main body control unit 115 also controls the body driving device 3. The main body control unit 115 is an example of the “control unit” in the present invention. Since each process performed by the brain function measuring apparatus 101 (calculation of the localization index LI, the display mode on the display unit 17, the operation process during rehabilitation, and the like) is the same as that in the first embodiment, Description is omitted.

  The main storage unit 116 stores a measurement control program and measurement data for performing brain function measurement, and performs a control process similar to that of the control device 4 (see FIG. 1) in the first embodiment on the main body control unit 115. An analysis / display control program to be executed is stored. The main storage unit 116 is configured to accumulate and store the index (side index LI) calculated by the main body control unit 115.

  With such a configuration, as shown in FIG. 5, the brain function measuring apparatus 101 of the second embodiment performs brain function measurement during rehabilitation, determines the presence or absence of motor recall, and indexes (side index LI). Calculation and display on the display unit 17 are performed.

  Other configurations of the second embodiment are the same as those of the first embodiment.

  In the second embodiment, the following effects can be obtained.

  In the second embodiment, as described above, the index (side index LI) is calculated based on the measurement result of the brain activity of the subject in rehabilitation, and the calculated index (side index LI) is displayed on the display unit 17. By providing the control unit 115 that performs the control, the user does not have the specialized knowledge for understanding the brain function measurement result data itself, like the rehabilitation support system 100 according to the first embodiment. In addition, it is possible to easily and objectively grasp the degree of recovery of brain function by rehabilitation using an index. Further, unlike the first embodiment in which the brain function measuring device 1, the display device 2, and the control device 4 are provided, in the second embodiment, the brain function measuring device 101 alone and brain function measurement and index calculation are performed. Since the display can be performed, the device (system) configuration can be simplified.

  Other effects of the second embodiment are the same as those of the first embodiment.

  The embodiment disclosed this time should be considered as illustrative in all points and not restrictive. The scope of the present invention is shown not by the above description of the embodiments but by the scope of claims for patent, and further includes all modifications within the meaning and scope equivalent to the scope of claims for patent.

  For example, in the first and second embodiments described above, an example in which the rehabilitation support system (brain function measuring device) is used for motor function recovery rehabilitation of a partially paralyzed patient associated with a brain disorder such as stroke has been described. Not limited to. The rehabilitation support system (brain function measuring device) of the present invention may be used for rehabilitation other than the above. The applied rehabilitation may be applied to rehabilitation of cerebral dysfunction classified into mental disorders such as depression in addition to rehabilitation of movement disorders such as paralysis due to cerebral dysfunction.

  As an example, for depression, the brain region on the dominant side of the left and right is active in healthy subjects, in response to the task of activating the prefrontal cortex (around Fp1, Fp2, F7, F3, Fz, F4, and F8 in FIG. 3). On the other hand, depression patients have activity in the brain region on the inferior side or on both sides, and as a whole, there is a unique tendency that the activity level (brain activity change) is smaller than that of healthy subjects. Therefore, it is considered that the lateralization index LI in the prefrontal cortex can be used as an index indicating the degree of recovery of brain function.

  In the first and second embodiments, the example in which the side index LI is used as an index indicating the degree of recovery of brain function is shown, but the present invention is not limited to this. In the present invention, an index other than the side index LI may be used. For example, the area (number of measurement channels) of a region where the brain activity change (NIRS signal) is larger than a predetermined threshold may be used as an index. That is, when hemiplegia occurs due to a stroke or the like, as described above, for a while from the onset, brain activity on the same side (left side) is activated in a wide range that is not involved in exercise in healthy individuals, With the recovery of motor function (recovery of brain function) by rehabilitation, the activity range of the brain region gradually narrows and the activity region is limited. Therefore, it is possible to determine the degree of recovery of the brain function by reducing the range (area) of the brain region that shows an activity such that the brain activity change exceeds a predetermined threshold. In this way, since the brain activity of a subject (patient) having a brain dysfunction exhibits a unique pattern different from that of a healthy person, the degree of brain function recovery can be determined. If it is information (distribution or analysis result of a measurement result of brain function) that represents a pattern peculiar to a subject (patient) who has, it can be used as an index.

  Moreover, although the said 1st and 2nd embodiment demonstrated the example of the structure which uses a body drive device, this invention is not limited to this. In the present invention, the body drive device may not be used.

  In the first and second embodiments, the example in which the lateralization index LI is calculated based on the brain function measurement results (optical measurement data) using the optical probes 5a and 5b has been described. Not limited. In the present invention, the side index LI may be calculated from a brain function measurement result (electroencephalogram measurement data) using the electrode probe 6. In addition, you may perform the brain function measurement for determination of a motor recall by optical measurement. Therefore, in the present invention, the brain function measuring device may be configured to perform only one of optical measurement and electroencephalogram measurement.

  Moreover, in the said 1st and 2nd embodiment, although the example which displays the lateralization index | index LI based on the brain function measurement result of the day was shown as a result of the day's rehabilitation, this invention is not limited to this. For example, the side index LI may be displayed for each rehabilitation exercise, or the side index LI may be displayed periodically for a predetermined period such as one week or one month. Further, instead of periodic display, the side index LI may be displayed when an operation input for displaying the side index LI is received from the user.

  In the first and second embodiments, the brain function measurement (optical measurement) for calculating the lateralization index LI for each movement (motor recall) in the flowchart shown in FIG. 5 (see step S6). Although the example which performs is demonstrated, this invention is not limited to this. For example, the brain function measurement (optical measurement) may be performed only at the last one of the predetermined number of exercises. Moreover, you may perform a brain function measurement (optical measurement) after completion | finish of training (between step S7 and S8).

  In the first and second embodiments, as shown in the display mode example of FIG. 4, the example in which the side index LI is displayed on the time-series graph 51 together with past values has been described. It is not limited to this. In the present invention, the display mode may not be a graph format, but may display the side index LI only by a numerical value, or may be a table format.

  Further, in the first and second embodiments, as shown in the display mode example of FIG. 4, the example has been described in which the message part 52 indicating the evaluation of the side index LI is displayed together with the side index LI. The present invention is not limited to this. A message indicating the evaluation of the side index LI may not be displayed.

  In the first and second embodiments, as shown in the display mode example of FIG. 4, when the lateralization index LI indicates an improvement in brain function, a message that gives up or encourages the subject is displayed on the message unit 52. Although the example to make was demonstrated, this invention is not limited to this. In the present invention, it is not necessary to display a sentence that compliments or encourages the subject.

DESCRIPTION OF SYMBOLS 1,101 Brain function measuring apparatus 2 Display apparatus 4 Control apparatus 5a, 5b Optical probe (detection terminal part)
6 Electrode probe (detection terminal)
17 Display unit 19 Measuring unit 42 Storage unit 51 Graph 52 Message unit 100 Rehabilitation support system 115 Main body control unit (control unit)

Claims (8)

A system for supporting rehabilitation of subjects with brain dysfunction,
A display device;
A brain function measuring device that measures the brain activity of the subject in rehabilitation;
Based on the measurement result of the brain activity of the subject in the rehabilitation, as an index indicating the degree of recovery of the brain function of the subject, information indicating a pattern different from that of a healthy person peculiar to the subject having a brain dysfunction is acquired.
A control device that performs control to display the acquired index on the display device,
The index indicating the degree of recovery of the brain function of the subject is an odor of a brain dysfunctional person and a healthy person.
The lateralization index indicating the left-right difference in brain function in areas with different brain function activation patterns,
Or, the brain function activation pattern is different in the area where the brain function disorder person and the healthy person are different.
The area of the brain region in which the change in brain activity exceeds a predetermined threshold,
Rehabilitation support system. The brain function measuring device is configured to measure a subject's brain activity during or after rehabilitation,
The rehabilitation support system according to claim 1, wherein the control device is configured to periodically acquire and display the index based on a measurement result of the brain function measuring device. A storage unit for storing the acquired index;
The rehabilitation support system according to claim 1, wherein the control device is configured to display the index acquired this time together with the past index stored in the storage unit on the display device. The control device includes the past index stored in the storage unit and the index acquired this time in a time-series graph format with the index indicating elapsed time and the recovery degree of brain function as axes. The rehabilitation support system according to claim 3, wherein the rehabilitation support system is configured to display on a display device. The control device, numerical data as an index indicating the recovery degree of the brain function of the subject,
The display indicating the evaluation of the numerical data is configured to be displayed on the display device.
The rehabilitation support system according to claim 1. When the numerical data as an index indicating the degree of recovery of the brain function of the subject indicates improvement in brain function, the control device displays a sentence that praises or encourages the subject as a display indicating the evaluation of the numerical data. The rehabilitation support system according to claim 6, which is configured. The brain function measuring device is configured to measure a subject's brain activity for each daily rehabilitation,
The said control apparatus is comprised so that the said parameter | index may be acquired and displayed based on the measurement result of the said brain function measuring apparatus of the day as a result of one day's rehabilitation.
Rehabilitation support system described in 1. A brain function measuring device used for rehabilitation of a subject with cerebral dysfunction,
A detection terminal for detecting a signal indicating the brain activity of the subject;
A measurement unit that acquires a detection signal of the detection terminal unit and measures a subject's brain activity;
A display unit;
Based on the measurement result of the brain activity of the subject in the rehabilitation, as an index indicating the degree of recovery of the brain function of the subject, information indicating a pattern different from that of a healthy person peculiar to the subject having a brain dysfunction is acquired.
A control unit that performs control to display the acquired index on the display unit,
The index indicating the degree of recovery of the brain function of the subject is an odor of a brain dysfunctional person and a healthy person.
The lateralization index indicating the left-right difference in brain function in areas with different brain function activation patterns,
Or, the brain function activation pattern is different in the area where the brain function disorder person and the healthy person are different.
The area of the brain region in which the change in brain activity exceeds a predetermined threshold,
Brain function measuring device.

Images