JP6458896B1 - Fertilized egg quality evaluation system, information processing apparatus, information processing method and program - Google Patents

Abstract

To provide a fertilized egg quality evaluation method, a fertilized egg quality evaluation system, a program, and an information processing apparatus capable of obtaining a quality evaluation result of a fertilized egg evaluated with high accuracy.
A fertilized egg quality evaluation system according to the present technology is a fertilized egg quality evaluation system including an information processing apparatus for performing quality evaluation of a fertilized egg by cloud computing, and is associated with unique identification information. An acquisition unit that acquires a plurality of observation images obtained by imaging a fertilized egg in time series from a terminal device, an analysis unit that generates fertilized egg analysis information based on the plurality of observation images, and the identification And an output unit that outputs the evaluation support information including the information and the fertilized egg analysis information to a computer that receives input of fertilized egg evaluation information based on the evaluation support information via the network. .
[Selection] Figure 7

Description

The present technology relates to a fertilized egg quality evaluation system, an information processing apparatus, an information processing method, and a program that can provide a quality evaluation result of a cell such as a fertilized egg .

  Conventionally, in the livestock industry that handles livestock, for example, a large number of fertilized eggs are collected from the uterus of cows, normal fertilized eggs are selected from the many fertilized eggs, and the fertilized eggs are collected with the cows from which the fertilized eggs are collected Is often transplanted into the uterus of another cow (for example, Patent Document 1). At this time, the quality of the fertilized egg, which is an important factor that affects the transplantation results after transplantation, is of great interest to those engaged in the field.

JP 07-170885 A

  Generally, the quality of a fertilized egg is determined by morphological findings using an optical microscope, an image processing apparatus, or the like. However, in the quality evaluation of a fertilized egg before transplantation, the morphological evaluation method as described above not only requires skill but also tends to be subjective. For this reason, in recent years, when selecting a good fertilized egg, it is desired to obtain a quality evaluation result of the fertilized egg that is evaluated with higher accuracy than morphological findings.

In view of the circumstances as described above, an object of the present technology is to provide, for example, a fertilized egg quality evaluation system, an information processing apparatus, an information processing method, and a program capable of obtaining a quality evaluation result of a fertilized egg evaluated with high accuracy. It is in.

In order to achieve the above object, a fertilized egg quality evaluation system according to an embodiment of the present technology includes an information processing apparatus for performing quality evaluation of a fertilized egg by cloud computing.
The information processing apparatus includes an acquisition unit, an analysis unit, and an output unit.
The said acquisition part acquires the identification information and time-lapse image of a fertilized egg from a producer via a network.
The analysis unit, for each fertilized egg linked to the identification information, for a learned model generated using learning data including a time-lapse image of a fertilized egg and movement information based on the time-lapse image of the fertilized egg By applying this time-lapse image, fertilized egg analysis information for each fertilized egg is generated.
The output unit outputs evaluation support information including the identification information and fertilized egg analysis information for each fertilized egg linked to the identification information to the embryo cultivator or the producer via the network.
The evaluation support information is information displayed on a web browser capable of receiving fertilized egg evaluation information for each fertilized egg input by the embryo cultivator or the producer based on the evaluation support information.

The motion information may be a total value of motion velocity vectors in a fertilized egg cell.

The evaluation support information may be information displayed on a web dashboard.

The fertilized egg evaluation information may include information regarding shipment of the fertilized egg.

You may further comprise the terminal device comprised so that transmission of the time-lapse image of a fertilized egg was possible via the said network.

The acquisition unit may acquire, as the identification information, at least one of information on a sperm to be a fertilized egg and an egg, mating information on a fertilized egg, or information on a culture container for culturing a fertilized egg via the network. Good.

The mating information may be at least one of information on a male from which the sperm has been collected or information on a female from which the egg has been collected.

The information related to the culture container may be at least one of information related to the placement of the culture container or information related to the placement of the fertilized egg.

The information processing apparatus may be a web server.

The learning data includes at least one of a fertilized egg development time, a fertilized egg quality information, a fertilized egg shape information, a fertilized egg compaction information, a fertilized egg contraction information, a fertilized egg expansion information, or a fertilized egg activity pause information. May further be included.

The analysis unit generates the fertilized egg analysis information by applying the time-lapse image of the fertilized egg to a discriminator generated based on an algorithm using at least a time-lapse image of the fertilized egg collected from the producer as learning data. May be.

The information processing apparatus further includes an image processing unit that normalizes a time-lapse image of a fertilized egg before generating the fertilized egg analysis information,
  The analysis unit may generate the fertilized egg analysis information by applying a time-lapse image of the normalized fertilized egg to the classifier.

The analysis unit applies the time-lapse image and identification information of the fertilized egg to a classifier generated based on an algorithm that uses the time-lapse image and identification information of the fertilized egg collected from the producer as learning data. Egg analysis information may be generated.

By applying the time-lapse image of the fertilized egg and the culture environment information to the discriminator generated based on the algorithm using the time-lapse image of the fertilized egg collected from the producer and the culture environment information as learning data, The fertilized egg analysis information may be generated.

The analysis unit, as the fertilized egg analysis information, the imaging time of imaging the fertilized egg, the development time of the fertilized egg, the quality information of the fertilized egg, the shape information of the fertilized egg, the movement information of the fertilized egg, the compaction information of the fertilized egg, At least one of the contraction information of the fertilized egg, the extended information of the fertilized egg, or the activity rest information of the fertilized egg may be generated.

The terminal may output the fertilized egg sales information including the fertilized egg analysis information and the evaluation support information for supporting the quality evaluation of the fertilized egg and the fertilized egg evaluation information based on the evaluation support information to the breeder. Good.

The acquisition unit acquires an acquisition request for acquiring a fertilized egg from the breeding company via the network,
  The output unit may output a command corresponding to the acquisition request to the producer or the embryo culture person.

The acquisition unit acquires a purchase request for purchasing a fertilized egg from a breeding company via the network,
  The output unit may output a command corresponding to the purchase request to the producer or the embryo culture person.

The information processing apparatus may further include a determination unit that determines whether or not to respond to the purchase request from the breeding company.

The acquisition unit acquires progress information about a fertilized egg from a breeding company via the network,
  The output unit may output the progress information to the producer or the embryo cultivator via the network.

The acquisition unit may acquire at least one of transplant information, fertilization information, fattening information, and meat information regarding a fertilized egg as the progress information.

The output unit may output the evaluation support information updated at predetermined time intervals to the embryo cultivator or the producer.

The acquisition unit may acquire a time-lapse image of a fertilized egg associated with at least the identification information in real time.

In order to achieve the above object, a fertilized egg quality evaluation system according to an embodiment of the present technology includes an information processing apparatus for performing quality evaluation of a fertilized egg by cloud computing.
  The information processing apparatus includes an acquisition unit, an analysis unit, and an output unit.
  The said acquisition part acquires the identification information and time-lapse image of a fertilized egg from a producer via a network.
  The analysis unit, for each fertilized egg linked to the identification information, for a learned model generated using learning data including a time-lapse image of a fertilized egg and movement information based on the time-lapse image of the fertilized egg By applying this time-lapse image, fertilized egg analysis information for each fertilized egg is generated.
  The output unit outputs evaluation support information including the identification information and fertilized egg analysis information for each fertilized egg linked to the identification information to the embryo cultivator or the producer via the network.
  The evaluation support information is displayed on a web browser displayed on a terminal capable of receiving fertilized egg evaluation information for each fertilized egg input by the embryo culture person or the producer based on the evaluation support information. Information.

In order to achieve the above object, an information processing apparatus according to an embodiment of the present technology includes an acquisition unit, an analysis unit, and an output unit.
  The acquisition unit acquires identification information and a time-lapse image of a fertilized egg from a producer through a network.
  The analysis unit, for each fertilized egg linked to the identification information, for a learned model generated using learning data including a time-lapse image of a fertilized egg and movement information based on the time-lapse image of the fertilized egg By applying the time-lapse image of, fertilized egg analysis information for each fertilized egg is generated
  The output unit outputs evaluation support information including the identification information and fertilized egg analysis information for each fertilized egg linked to the identification information to the embryo cultivator or the producer via the network.
  The evaluation support information is information displayed on a web browser capable of receiving fertilized egg evaluation information for each fertilized egg input by the embryo cultivator or the producer based on the evaluation support information.

In order to achieve the above object, an information processing method according to an aspect of the present technology includes:
  Obtaining identification information and time-lapse images of fertilized eggs from producers via a network;
  A time-lapse image for each fertilized egg linked to the identification information is applied to a learned model generated using learning data including a time-lapse image of a fertilized egg and movement information based on the time-lapse image of the fertilized egg. A step of generating fertilized egg analysis information for each fertilized egg,
  A step of outputting evaluation support information including the identification information and fertilized egg analysis information for each fertilized egg linked to the identification information to the embryo cultivator or producer via the network.
The evaluation support information is information displayed on a web browser capable of receiving fertilized egg evaluation information for each fertilized egg input by the embryo cultivator or the producer based on the evaluation support information.
In order to achieve the above object, a program according to an embodiment of the present technology causes an information processing device to execute the following steps.
  A step of acquiring fertilized egg identification information and a time-lapse image from a producer through a network.
  A time-lapse image for each fertilized egg linked to the identification information is applied to a learned model generated using learning data including a time-lapse image of a fertilized egg and movement information based on the time-lapse image of the fertilized egg. Generating fertilized egg analysis information for each fertilized egg.
A step of outputting evaluation support information including the identification information and fertilized egg analysis information for each fertilized egg linked to the identification information to an embryo culture person or a producer via the network.
The evaluation support information is information displayed on a web browser capable of receiving fertilized egg evaluation information for each fertilized egg input by the embryo cultivator or the producer based on the evaluation support information.

  As described above, according to the present technology, it is possible to provide a fertilized egg quality evaluation method, a fertilized egg quality evaluation system, a program, and an information processing apparatus that can obtain a quality evaluation result of a fertilized egg evaluated with high accuracy. Note that the above effects are not necessarily limited, and any of the effects shown in this specification or other effects that can be grasped from this specification together with the above effects or instead of the above effects. May be played.

It is a mimetic diagram showing roughly an example of composition of a fertilized egg quality evaluation system concerning this art. It is a mimetic diagram showing the example of composition of the observation system of this art. It is the schematic diagram which looked at the culture container group installed on the observation stage of the observation apparatus of this technique from the light source side. It is a figure which shows the cross section of the said culture container typically. It is the top view which looked at the said culture container from the light source side. It is a schematic diagram which expands and shows the imaging | photography area which looked at the said culture container from the light source side. It is a block diagram of a fertilized egg quality evaluation system concerning a 1st embodiment of this art. It is a figure which shows the business model of the said fertilized egg quality evaluation system. It is a flowchart which shows the method of evaluating the quality of the fertilized egg of the said fertilized egg quality evaluation system. It is a schematic diagram which shows a mode that the imaging part of this technique images a several fertilized egg. It is a conceptual diagram which shows a 1st time lapse image virtually. It is a conceptual diagram which shows a 2nd time lapse image virtually. It is a block diagram which shows simply the processing procedure of general specialization type AI. It is a block diagram of a fertilized egg quality evaluation system concerning a 2nd embodiment of this art. It is a flowchart which shows the method of evaluating the quality of the fertilized egg of the said fertilized egg quality evaluation system. It is a block diagram of a fertilized egg quality evaluation system concerning a 3rd embodiment of this art. It is a flowchart which shows the method of evaluating the quality of the fertilized egg of the said fertilized egg quality evaluation system. It is a block diagram of a fertilized egg quality evaluation system concerning a 4th embodiment of this art. It is a flowchart which shows the method of evaluating the quality of the fertilized egg of the said fertilized egg quality evaluation system. It is a block diagram of a fertilized egg quality evaluation system concerning a 5th embodiment of this art. It is a figure which shows the outline | summary of the fertilized egg analysis support of the said fertilized egg quality evaluation system. It is a flowchart which shows the method of evaluating the quality of the fertilized egg of the said fertilized egg quality evaluation system. It is a figure which shows the other outline | summary of the fertilized egg analysis support of the said fertilized egg quality evaluation system.

  Hereinafter, embodiments of the present technology will be described with reference to the drawings.

  A fertilized egg quality evaluation system according to the present technology provides information on quality evaluation of fertilized eggs evaluated with high accuracy via a network such as the Internet, a fertilized egg manager, a fertilized egg quality evaluator, a fertilized egg transplanter, It is a network system that can be mutually acquired between.

  Here, in this technology, a fertilized egg manager is a producer that cultures and manages fertilized eggs when handling fertilized eggs of domestic animals such as cattle, and this fertilized egg when handling fertilized eggs of humans. Corresponds to fertility clinics and hospitals that culture and manage eggs.

  The producer is equivalent to, for example, domestic and foreign companies that manage the culture environment for culturing fertilized eggs, organizations such as cooperatives, or various research institutions such as universities.

  A fertilized egg quality evaluator is, for example, an embryo cultivator or a staff member who assists an embryo cultivator, a producer, a producer who produces fertilized eggs, or a doctor or staff member who belongs to a fertility clinic or hospital. It corresponds to.

  A fertilized egg transplanter refers to, for example, a farmer who grows a fertilized egg to an adult and sells the adult to the market, or a group of a plurality of farmers (for example, agricultural cooperatives). When a human fertilized egg is handled, it corresponds to a clinic or a hospital that transplants the fertilized egg for fertility treatment. The details of the fertilized egg quality evaluation system for fertilized eggs of livestock such as cattle will be described below.

<< First Embodiment >>
<Outline of fertilized egg quality evaluation system>
FIG. 1 is a schematic diagram schematically showing a configuration example of a fertilized egg quality evaluation system 100 according to the present embodiment. As shown in FIG. 1, the fertilized egg quality evaluation system 100 includes a terminal device 10, an information processing device 20, a first terminal 30, and a second terminal 40.

  In the present embodiment, the terminal device 10, the information processing device 20, the first terminal 30, and the second terminal 40 are connected via a network N so that they can communicate with each other. The network N may be, for example, the Internet, a mobile communication network, a local area network, or the like, or may be a network in which these plural types of networks are combined.

[Terminal device]
As shown in FIG. 1, the terminal device 10 is composed of a plurality of gateway terminals 10a, and these gateway terminals 10a communicate with the observation device 202 (fertilized egg manager) via the control recording PC 205 (see FIG. 2). Or it is connected by wire. The observation device 202 of this embodiment is handled by a fertilized egg manager.

  In the fertilized egg quality evaluation system 100 of this embodiment, typically, as shown in FIG. 1, a plurality of observation devices 202 (fertilized egg managers) are connected to the information processing device 20 via the terminal device 10. However, the present invention is not limited to this, and a single observation device 202 (fertilized egg manager) may be connected to the information processing device 20 via the terminal device 10.

(Observation system)
FIG. 2 is a schematic diagram illustrating a configuration example of an observation system 200 including the observation apparatus 202 according to the present embodiment. Note that the X, Y, and Z axes shown in FIG. 2 are triaxial directions orthogonal to each other, and are common to the following drawings.

  As shown in FIG. 2, the observation system 200 includes an incubator 201, an observation device 202, a humidity / temperature / gas control unit 203, a detection unit 204, a control recording PC 205, a display device 206, and an input unit 207. Have.

  The incubator 201 is a culture device that accommodates the observation device 202, the humidity / temperature / gas control unit 203, and the detection unit 204, and has a function of keeping the temperature, humidity, and the like therein constant. The incubator 201 is configured to allow any gas to flow in. Although the kind of the said gas is not specifically limited, For example, they are nitrogen, oxygen, a carbon dioxide, etc.

  The observation apparatus 202 includes an imaging unit 2021, a light source 2022, and a culture container group 2023. The imaging unit 2021 is configured to image the fertilized egg F (see FIG. 4) accommodated in the culture container 2023a (dish) in time series and generate an observation image of the fertilized egg F.

  The imaging unit 2021 includes a lens barrel that includes a lens group that can move in the optical axis direction (Z-axis direction), a complementary metal oxide semiconductor (CMOS) that captures subject light that passes through the lens barrel, and a charge coupled device (CCD). And the like, and a drive circuit for driving them.

  The imaging unit 2021 is configured to be movable in the optical axis direction (Z-axis direction) and the horizontal direction (direction orthogonal to the Z-axis direction), and moves the fertilized egg F accommodated in the culture vessel 2023a while moving in the horizontal direction. Take an image. Further, the imaging unit 2021 may be configured to be able to capture not only a still image but also a moving image.

  The imaging unit 2021 according to the present embodiment is typically a visible light camera, but is not limited thereto, and may be an infrared (IR) camera, a polarization camera, or the like.

  The light source 2022 irradiates the culture container 2023a with light when the imaging unit 2021 images the fertilized egg F in the culture container 2023a. As the light source 2022, for example, an LED (Light Emitting Diode) that emits light of a specific wavelength is employed. In the case where the light source 2022 is an LED, for example, a red LED that emits light having a wavelength of 640 nm is employed.

  The culture container group 2023 includes a plurality of culture containers 2023 a and is installed on the observation stage S between the imaging unit 2021 and the light source 2022. The observation stage S is configured to be able to transmit light emitted from the light source 2022.

  FIG. 3 is a schematic view of the culture container group 2023 installed on the observation stage S of the observation apparatus 202 as viewed from the light source 2022 side. As shown in FIG. 3, for example, six culture vessels 2023a are arranged in a matrix on the observation stage S, three in the X-axis direction, and two in the Y-axis direction.

  FIG. 4 is a diagram schematically showing a cross section of the culture vessel 2023a. As shown in FIG. 4, the culture container 2023a is provided with a plurality of wells W. The wells W are provided in a matrix (see FIG. 6) in the culture container 2023a, and are configured to accommodate one fertilized egg F.

  In addition to the well W provided in the culture container 2023a, the culture medium C and the oil O are injected. The oil O has a function of suppressing evaporation of the culture solution C by coating the culture solution C.

  FIG. 5 is a schematic diagram (plan view) of the culture vessel 2023a viewed from the light source 2022 side. The culture vessel 2023a has a well region E1 in which a plurality of wells W are formed. The diameter D1 of the culture vessel 23a and the diameter D2 of the well region E1 are not particularly limited. For example, the diameter D1 is about 35 mm, and the diameter D2 is about 20 mm.

  The well region E1 has an imaging region E2 that is an imaging target of the imaging unit 2021. The imaging area E2 is divided into four equal areas into four imaging areas L1 to L4 as shown in FIG. The length D3 of one side of each of the imaging areas L1 to L4 is, for example, about 5 mm.

  FIG. 6 is a schematic diagram showing an enlarged view of the shooting area L1 viewed from the light source 2022 side. The imaging area L1 includes 72 wells W among the plurality of wells W provided in the well region E1, and is divided into 12 equal parts for each POS (Position) region.

  The POS regions P1 to P12 each include six wells W in which three wells W are arranged in the X-axis direction and two in the Y-axis direction. In the “observation image / identification information acquisition” step (see FIG. 9) described later, the imaging unit 2021 according to the present embodiment images the fertilized eggs F stored in the wells W for each POS region in time series. FIG. 6 is a schematic diagram showing the shooting area L1 in an enlarged manner, but the shooting areas L2 to L4 have the same configuration as the shooting area L1.

  The material constituting the culture vessel 2023a is not particularly limited. For example, an inorganic material such as glass or silicon, polystyrene resin, polyethylene resin, polypropylene resin, ABS resin, nylon, acrylic resin, fluororesin, polycarbonate resin, polyurethane resin, The transparent body is made of an organic material such as methylpentene resin, phenol resin, melamine resin, epoxy resin, or vinyl chloride resin, and transmits light emitted from the light source 2022. Alternatively, the culture vessel 23a may be made of the materials listed above except for a portion through which light emitted from the light source 2022 is transmitted, or may be made of a metal material.

  The humidity / temperature / gas control unit 203 controls the temperature and humidity in the incubator 201 and the gas introduced into the incubator 201, and creates an environment suitable for the growth of the fertilized egg F. The humidity / temperature / gas control unit 203 can control the temperature in the incubator 201 to about 38 ° C., for example.

  The detection unit 204 is connected to the control recording PC 205 by wireless or wired, and is configured to detect the temperature, atmospheric pressure, illuminance, oxygen concentration, and the like in the incubator 201 and output them to the control recording PC 205. The detection unit 204 is, for example, a solar panel type or battery type IoT (Internet of Things) sensor, and the type thereof is not limited.

  The control recording PC 205 is connected to the imaging unit 2021, the light source 2022, the humidity / temperature / gas control unit 203, the detection unit 204, and the gateway terminal 10a. The control recording PC 205 is configured to control the culture environment of the fertilized egg F by controlling these based on the outputs of the imaging unit 2021, the light source 2022, the detection unit 204, and the humidity / temperature / gas control unit 203.

  For example, the control recording PC 205 is configured to store the culture environment information output from the detection unit 204 and transmit the culture environment information to the gateway terminal 10a. Here, the culture environment information of the present embodiment is, for example, information on the pH of the culture solution C, the temperature, the humidity, and the oxygen concentration in the incubator 201, and is also synonymous in the following description.

  The gateway terminal 10a that has received the culture environment information acquires information about at least one of the pH of the culture medium C, the temperature, the humidity, and the oxygen concentration in the incubator 201 as the culture environment information via the network N. 7). The acquisition unit 24 outputs the acquired culture environment information to the storage unit 28 (see FIG. 7), and the culture environment information is stored in the storage unit 28.

  In addition, the control recording PC 205 stores the fertilized eggs F individually accommodated in the plurality of wells W, such as information on sperm and eggs that become the fertilized eggs F, mating information on the fertilized eggs F, information on the culture container 2023a, and the like. Stored as identification information for identification. The control recording PC 205 is configured to be able to transmit this identification information to the gateway terminal 10a. The identification information will be described later.

  The display device 206 is configured to be able to display an observation image taken by the imaging unit 2021, culture environment information, identification information, and the like. The display device 206 is a display device using, for example, liquid crystal, organic EL (Electro-Luminescence), or the like.

  The input unit 207 is an operation device such as a keyboard and a mouse for inputting an operation of a fertilized egg manager. The input unit 207 according to the present embodiment may be a touch panel configured integrally with the display device 206 or the like.

  As shown in FIG. 1, the terminal device 10 of the present embodiment is preferably composed of a plurality of gateway terminals 10a from the viewpoint of improving the analysis accuracy of the information processing device 50, but from a single gateway terminal 10a. It may be configured. In this case, the single gateway terminal 10a may be connected to a plurality of observation apparatuses 202 (fertilized egg managers) wirelessly or by wire via the control recording PC 205.

  The gateway terminal 10a is typically a general-purpose gateway configured to be able to mutually convert different protocols and address systems, but is not limited to this, and is a PC (Personal Computer) set to serve as a gateway. Or the like.

[Information processing device]
The information processing apparatus 20 includes hardware necessary for a computer such as a CPU (Central Processing Unit) 21, a ROM (Read Only Memory) 22, and a RAM (Random Access Memory) 23.

  The CPU 21 loads a program according to the present technology stored in the ROM 22 to the RAM 23 and executes it. Thereby, each block operation of the information processing apparatus 20 to be described later is controlled.

  The ROM 22 is a memory device in which various data and programs used in the information processing apparatus 20 are fixedly stored.

  The RAM 23 is a memory element such as an SRAM (Static Random Access Memory) used as a work area for the CPU 21 and a temporary storage space for history data.

  The program is installed in the information processing apparatus 20 via various storage media (internal memory), for example. Alternatively, program installation may be executed via the Internet or the like. The information processing apparatus 20 of the present embodiment is a web server for performing quality evaluation of the fertilized egg F by cloud computing, but is not limited thereto, and for example, any other computer such as a PC may be used. .

  FIG. 7 is a block diagram of the fertilized egg quality evaluation system 100 according to the present embodiment. As shown in FIG. 7, the information processing apparatus 20 includes an acquisition unit 24, an analysis unit 25, an output unit 26, an image processing unit 27, a storage unit 28, an I / O interface 29, and a bus 210. Have.

  The acquisition unit 24 acquires a plurality of observation images in which the fertilized eggs F associated with the unique identification information are captured in time series from the plurality of gateway terminals 10a (terminal device 10) via the network N.

  The analysis unit 25 generates fertilized egg analysis information based on a plurality of observation images obtained by imaging the fertilized egg F in time series. The analysis unit 25 according to the present embodiment includes a discriminator generated based on an algorithm using time-lapse images of fertilized eggs collected from a plurality of fertilized egg managers as learning data. The discriminator will be described later.

  The output unit 26 outputs evaluation support information including identification information unique to the fertilized egg F and fertilized egg analysis information to a computer that receives input of fertilized egg evaluation information based on the evaluation support information via the network N.

  The image processing unit 27 performs predetermined image processing on a plurality of observation images obtained by capturing the fertilized eggs F in time series. For example, when the fertilized egg F is imaged while being cultured for each well in the culture container 2023a, the image processing unit 27 performs image cutting processing (trimming processing) or the like on a plurality of observation images before image analysis (step) (See S02). As a result, it is possible to use an enlarged image obtained by cutting the fertilized eggs F one by one for analysis, thereby improving analysis accuracy.

  The storage unit 28 includes, for example, a ROM 22 that stores a program executed by the CPU 21 and a RAM 23 that is used as a work memory or the like when the CPU 21 executes processing. Furthermore, the storage unit 28 may include a nonvolatile memory such as an HDD (Hard Disc Drive) and a flash memory (SSD: Solid State Drive). Thereby, the input information input from the terminal device 10, the 1st terminal 30, and the 2nd terminal 40, the analysis result of the analysis part 25, etc. can be memorize | stored.

  The I / O interface 29 is communicably connected to the terminal device 10 and the first and second terminals 30 and 40 via the network N, and includes an acquisition unit 24 and an output unit 26. The I / O interface 29 functions as an input / output interface between the terminal device 10 and the first and second terminals 30 and 40.

  The bus 210 is a signal transmission path for inputting and outputting various signals between the units of the information processing apparatus 20. The CPU 21, ROM 22, RAM 23, and I / O interface 29 are connected to each other through a bus 210.

  Note that the functions of the acquisition unit 24, the analysis unit 25, the output unit 26, the image processing unit 27, and the storage unit 28 included in the information processing apparatus 50 are not limited to those described above, and these details are described in the fertilized egg quality evaluation method described later. I will describe the functions.

[First terminal]
The first terminal 30 is handled by a fertilized egg quality evaluator. The first terminal 30 includes, via the network N, a receiving unit 30a that receives information output from the output unit 26 or the second terminal 40, an input unit 30b that receives input from a fertilized egg quality evaluator, and an input unit And a transmission unit 30c that transmits information input via 30b and information received by the reception unit 30a.

  The first terminal 30 is typically a computer such as a laptop PC or a desktop PC, but is not limited thereto, and may be, for example, a smart device or a tablet terminal.

[Second terminal]
The second terminal 40 is handled by a fertilized egg transplanter. The second terminal 40 includes a receiving unit 40a that receives information output from the output unit 26 or the first terminal 30 via the network N, an input unit 40b that receives input from a fertilized egg transplanter, and an input unit 40b. And a transmitter 40c for transmitting information received via the receiver and information received by the receiver 40a.

  The second terminal 40 is typically a smart device or a tablet terminal, but is not limited thereto, and may be another arbitrary computer such as a laptop PC or a desktop PC.

<Method of evaluating fertilized egg quality>
FIG. 8 is a diagram illustrating a business model of the fertilized egg quality evaluation system 100 according to the present embodiment, and is a diagram illustrating a flow from analyzing the quality of the fertilized egg F to obtaining progress information regarding the fertilized egg F. FIG. 9 is a flowchart showing a method for evaluating the quality of the fertilized egg F in the fertilized egg quality evaluation system 100. Hereinafter, the quality evaluation method of the fertilized egg F will be described with reference to FIG. 9 as appropriate.

[Step S01: Obtain Observation Image / Identification Information]
First, a fertilized egg quality evaluator inputs identification information regarding the fertilized egg F to the control recording PC 205 via the input unit 207. The identification information input to the control recording PC 205 is stored in the control recording PC 205 and transmitted to the gateway terminal 10a. The gateway terminal 10a that has received the identification information transmits the identification information to the acquisition unit 24 via the network N, and the acquisition unit 24 acquires the identification information.

  Here, the identification information of the present embodiment is, for example, information related to sperm and eggs that become the fertilized egg F, mating information related to the fertilized egg F, and information related to the culture container 2023a, and is also synonymous in the following description. . The acquisition unit 24 acquires at least one of these pieces of information as identification information.

  The sperm that becomes the fertilized egg F and the information on the ovum are, for example, semen volume, total sperm count, total motile sperm count, viscosity, sperm concentration, forward motility rate, non-forward motility rate, normal morphology rate, Motor sperm concentration (MSC), fast forward motility sperm concentration (PMSC-a), slow forward motility sperm concentration (PMSC-b), functional motility sperm concentration (FSC), sperm automaticity index (SMI), average sperm velocity, etc. It is.

  On the other hand, as for eggs, for example, egg amount, total egg number, egg age, AMH (anti-Muller tube hormone) value, LH (luteal stimulating hormone) value, FSH (follicle stimulating hormone) value, E2 (elastradiol) value. , P4 (progesterone) value, follicular hormone (estrogen) value, and the like.

  The mating information regarding the fertilized egg F includes, for example, information (weight, body height (height), age, pedigree, medical history, health status, etc.) regarding the male (male) from which the sperm was collected, and the female (female) from which the egg was collected. ) (Weight, body height (height), age, pedigree, medical history, ovary age, total number of births, health status, birth record, etc.).

  The information regarding the culture container 2023a is, for example, the culture container 2023a such as which culture container 2023a contains the fertilized egg F to be evaluated among the six culture containers 2023a on the observation stage S (see FIG. 3). Information on the position of the fertilized egg F, such as which area the fertilized egg F to be evaluated is in among the four imaging areas L1 to L4 (see FIG. 5).

  Subsequently, when the acquisition unit 24 acquires the identification information from the gateway terminal 10a via the network N, the output unit 26 outputs an imaging command for imaging the fertilized egg F associated with the identification information via the network N. Output to the gateway terminal 10a. The gateway terminal 10 a that has received the imaging command transmits this imaging command to the control recording PC 205.

  FIG. 10 is a schematic diagram illustrating how the imaging unit 2021 images a plurality of fertilized eggs F, and is a diagram illustrating a movement route of the imaging unit 2021. The control recording PC 205 that has received the imaging command controls the imaging unit 2021 in accordance with the imaging command.

  Thereby, the several fertilized eggs F accommodated in the several well W are imaged in time series for every POS (Position) area | region. At this time, as shown in FIG. 10, the visual field range 2021a of the imaging unit 2021 moves in the order of the POS region P1 to the POS region P12 at intervals of about 3 seconds according to the movement route R.

  And this operation | work is performed with respect to all the culture containers 2023a installed in the observation stage S, and is repeated a specified number of times. As a result, an image including six fertilized eggs F (hereinafter, a first time-lapse image G1) is generated, and the first time-lapse image G1 is transmitted to the control recording PC 205.

  The control recording PC 205 to which the first time lapse image G1 is input transmits the first time lapse image G1 to the gateway terminal 10a. The gateway terminal 10a that has received the first time lapse image G1 transmits the first time lapse image G1 to the acquisition unit 24 via the network N, and the acquisition unit 24 acquires the first time lapse image G1.

  FIG. 11 is a conceptual diagram virtually showing the first time-lapse image G1. The first time-lapse image G1 of the present embodiment is generated in time series along the time axis T as shown in FIG. 11 for each of the POS regions P1 to P12. In this specification, a plurality of observation image data along the time series shown in FIG. 11 is referred to as a first time-lapse image G1.

  The imaging interval and the number of captured images of the imaging unit 2021 in the observation system 200 can be arbitrarily set. For example, assuming that the imaging period is one week, the imaging interval is 15 minutes, and when nine stacks are imaged by changing the focal length in the depth direction (Z-axis direction), six fertilized eggs F are obtained for one POS region. About 6000 laminated images are obtained. Thereby, a three-dimensional image of the fertilized egg F can be acquired.

  The acquisition unit 24 outputs the first time-lapse image G1 and the identification information acquired from the gateway terminal 10a via the network N to the storage unit 28, and these are stored in the storage unit 28. In addition, the acquisition unit 24 outputs the acquired first time-lapse image G1 to the image processing unit 27 and outputs identification information to the output unit 26.

[Step S02: Image Processing]
The image processing unit 27 processes (trims) the first time-lapse image G1 output from the acquisition unit 24 in units of fertilized eggs F. Thereby, an image including one fertilized egg F (hereinafter, second time-lapse image G2) is generated. Next, the image processing unit 27 outputs the second time lapse image G <b> 2 to the storage unit 28, and the second time lapse image G <b> 2 is stored in the storage unit 28.

  FIG. 12 is a conceptual diagram virtually showing the second time-lapse image G2. The second time-lapse image G2 of the present embodiment is generated in time series along the time axis T as shown in FIG. In this specification, a plurality of observation image data along the time series shown in FIG. 12 is referred to as a second time-lapse image G2.

  Next, the image processing unit 27 performs predetermined image processing on the second time-lapse image G2. The second time lapse image G2 subjected to the image processing by the image processing unit 27 is output to the analysis unit 25 and the storage unit 28, and the second time lapse image G2 is stored in the storage unit 28. Hereinafter, some application examples of step S02 will be described.

(Application example 1)
The image processing unit 27 performs normalization on each image constituting the second time-lapse image G2. Thereby, for example, not only the noise of the second time lapse image G2 is removed, but also the second time lapse image can be made uniform before analysis. Therefore, the feature of the second time lapse image is easily extracted.

  Normalization performed by the image processing unit 27 of the present embodiment on the second time-lapse image G2 is, for example, normalization processing that unifies the color and brightness of each image constituting the second time-lapse image G2, or standardization. Processing, decorrelation processing or whitening processing.

(Application example 2)
The image processing unit 27 performs a probability process, a binarization process, an overlay process, and the like by deep learning analysis on the second time-lapse image G2. Thereby, for example, the contour line of the fertilized egg F in the second time-lapse image G2 is extracted.

(Application example 3)
The image processing unit 27 forms a mask area along the shape of the fertilized egg F for each image constituting the second time-lapse image G2. Thereby, the analysis area | region (recognition area | region) of the fertilized egg F in the 2nd time lapse image G2 becomes clear, and the shape of the fertilized egg F can be recognized correctly. With this technique, for example, the shape of the zona pellucida forming the outer shape of the fertilized egg F, the blastocyst, cell blastomere, morula, etc. inside the fertilized egg F can be accurately recognized.

[Step S03: Analysis Processing]
The information processing apparatus 20 according to the present embodiment is a cloud server that uses a so-called specialized AI (Artificial Intelligence) that replaces the user's intellectual work. FIG. 13 is a block diagram schematically showing a processing procedure of a general specialized AI.

  Specialized AI is a mechanism that allows a result to be obtained by applying arbitrary input data to a learned model constructed by incorporating learning data into an algorithm that functions as a learning program, as a large framework. is there. Hereinafter, some application examples of step S03 will be described with reference to FIG. 13 as appropriate.

(Application example 1)
Shape information, movement information, compaction information, contraction information, expansion information, activity pause information based on time-lapse images of fertilized eggs collected from a plurality of fertilized egg managers via the network N, which are stored in advance in the storage unit 28 The analysis unit 25 reads from the storage unit 28 at least one of the growth information and quality information based on the findings. These pieces of information correspond to “learning data” in FIG.

  Here, the quality information is, for example, the development state and quality ranking of the fertilized egg F, or the zona pellucida of the fertilized egg F or the cells inside the fertilized egg F (blastocyst, cell blastomere, morula, etc.), This is information on the pronucleus, polar body, nucleus in the blastomere, fragmentation, and egg cell margin transparent region (Halo).

  The shape information is, for example, information related to changes in diameter, area, volume, roundness, etc. along the time series of the fertilized egg F in the process of development of the fertilized egg F.

  The movement information is, for example, information related to a change in the amount of movement along the time series of cells inside the fertilized egg F in the process of development of the fertilized egg F. This change in the amount of movement is, for example, the minimum speed, maximum speed, maximum acceleration, average speed, average acceleration, median, standard deviation of the motion vector of the cells inside the fertilized egg F, or the movement of the cells inside the fertilized egg F. This is a change along the time series of the total value of the velocity vectors or the total value of the motion acceleration vectors of the cells inside the fertilized egg F.

  The compaction information is, for example, the compaction time (state in which the divided cells are fused into one lump) when the fertilized egg F undergoes a morphological change from the 16-cell stage to the morula stage.

  The contraction information includes, for example, the number of contractions, contraction diameter, contraction speed, contraction time, contraction strength, contraction strength, and contraction frequency of the fertilized egg F in the process of the development of the fertilized egg F. The expansion information is, for example, the number of expansions, the expansion diameter, the expansion speed, the expansion time, the expansion interval, the expansion strength, and the expansion frequency of the fertilized egg F in the process of the development of the fertilized egg F.

  The activity rest information is information on the lag-phase (cell rest period) in the process of the development of the fertilized egg F, for example.

  The growth information based on the findings is, for example, the quality of the fertilized eggs (development state, number of cells, cell symmetry, etc.) judged by the expert such as an embryo cultivator based on the time-lapse images taken in time series. Sex, number of pronuclei, number of polar bodies, number of nuclei in cell blastomere, fragment, etc.).

  Regarding the “shape information”, “motion information”, “compaction information”, “shrinkage information”, “extended information”, “activity suspension information”, “growth information based on findings” and “quality information” listed above. Is also synonymous in the following description.

  Next, the analysis unit 25 constructs a first discriminator by incorporating the learning data read from the storage unit 28 into a preset first algorithm. Thereby, the analysis part 25 becomes a structure which has a 1st discriminator.

  Note that the first algorithm described above corresponds to the “algorithm” in FIG. 13 and functions as, for example, a machine learning algorithm. The first classifier corresponds to the “learned model” in FIG. The first classifier of the present embodiment is typically configured with a single learned model, but is not limited thereto, and may be configured with a combination of a plurality of learned models, for example.

  The type of machine learning algorithm is not particularly limited. For example, a neural network such as RNN (Recurrent Neural Network), CNN (Convolutional Neural Network) or MLP (Multilayer Perceptron) is used. In addition, any algorithm that executes a supervised learning method, an unsupervised learning method, a semi-supervised learning method, a reinforcement learning method, or the like may be used.

  Next, the analysis unit 25 generates the first fertilized egg analysis information by applying the first classifier constructed as described above to the second time-lapse image G2 output from the image processing unit 27.

  Specifically, the first time-lapse image is subjected to deep learning analysis by the first discriminator, thereby generating first fertilized egg analysis information. Then, the analysis unit 25 outputs the first fertilized egg analysis information to the output unit 26 and the storage unit 28, and the first fertilized egg analysis information is stored in the storage unit 28.

  Here, the analysis unit 25 of the present embodiment, as the first fertilized egg analysis information, the imaging time when the imaging unit 2021 images the fertilized egg F, the development time (culture time) of the fertilized egg F, quality information, shape information, At least one of motion information, compaction information, contraction information, extended information, and inactivity information is generated.

  In step S03, the second time-lapse image G2 described above corresponds to “input data” in FIG. 13, and the first fertilized egg analysis information corresponds to “result” in FIG.

(Application example 2)
Shape information, movement information, compaction information, contraction based on identification information of fertilized eggs collected from a plurality of fertilized egg managers via network N and time-lapse images of the fertilized eggs stored in advance in the storage unit 28 The analysis unit 25 reads from the storage unit 28 at least one of information, extended information, activity suspension information, growth information based on findings, and quality information. These pieces of information correspond to “learning data” in FIG.

  Next, the analysis unit 25 constructs a discriminator by incorporating the learning data read from the storage unit 28 into a preset algorithm. Thereby, the analysis part 25 becomes a structure which has a discriminator.

  The above-described algorithm corresponds to the “algorithm” in FIG. 13 and functions as a machine learning algorithm as listed above, for example. The classifier corresponds to the “learned model” in FIG.

  Next, the analysis unit 25 uses the classifier constructed as described above as identification information of the second time lapse image G2 output from the image processing unit 27 and the fertilized egg F associated with the second time lapse image G2. By applying, the first fertilized egg analysis information is generated.

  Specifically, the first time-lapse image and the identification information unique to the fertilized egg F are subjected to deep learning analysis using a discriminator, thereby generating first fertilized egg analysis information. Then, the analysis unit 25 outputs the first fertilized egg analysis information to the output unit 26 and the storage unit 28, and the first fertilized egg analysis information is stored in the storage unit 28.

  The second time-lapse image G2 and the identification information related to the fertilized egg F associated with the image G2 correspond to the “input data” in FIG. 13, and the first fertilized egg analysis information is the “result” in FIG. Is equivalent to.

(Application example 3)
Shape information, movement information, compaction information based on culture environment information of fertilized eggs collected from a plurality of fertilized egg managers via the network N and time-lapse images of the fertilized eggs, which are stored in the storage unit 28 in advance. The analysis unit 25 reads from the storage unit 28 at least one of contraction information, extended information, activity suspension information, growth information based on findings, and quality information. These pieces of information correspond to “learning data” in FIG.

  Next, the analysis unit 25 constructs a discriminator by incorporating the learning data read from the storage unit 28 into a preset algorithm. Thereby, the analysis part 25 becomes a structure which has a discriminator.

  The above-described algorithm corresponds to the “algorithm” in FIG. 13 and functions as a machine learning algorithm as listed above, for example. The classifier corresponds to the “learned model” in FIG.

  Next, the analysis unit 25 uses the identifier constructed as described above as the culture environment information of the fertilized egg F associated with the second time lapse G2 output from the image processing unit 27 and the second time lapse image G2. By applying, the first fertilized egg analysis information is generated.

  Specifically, first fertilized egg analysis information is generated by deep learning analysis of the second time-lapse image G2 and the culture environment information using a discriminator. Then, the analysis unit 25 outputs the first fertilized egg analysis information to the output unit 26 and the storage unit 28, and the first fertilized egg analysis information is stored in the storage unit 28.

  Note that the culture environment information regarding the fertilized egg F associated with the second time-lapse image G2 and the time-lapse image G2 described above corresponds to the “input data” in FIG. 13, and the first fertilized egg analysis information is the “result” of FIG. Corresponds to "thing".

(Application example 4)
Shape information, movement information, compaction information, contraction information, expansion information, activity pause information based on time-lapse images of fertilized eggs collected from a plurality of fertilized egg managers via the network N, which are stored in advance in the storage unit 28 The analysis unit 25 reads from the storage unit 28 at least one of the growth information and quality information based on the findings. These pieces of information correspond to “learning data” in FIG.

  Next, the analysis unit 25 constructs a second discriminator by incorporating the learning data read from the storage unit 28 into the first and second algorithms set in advance. Thereby, the analysis part 25 becomes a structure which has a 2nd discriminator.

  The first and second algorithms described above correspond to the “algorithm” in FIG. 13 and function as, for example, machine learning algorithms as listed above. The second classifier corresponds to the “learned model” in FIG. In the present embodiment, two algorithms are used to construct the second classifier, but the present invention is not limited to this. For example, a plurality of algorithms different from the first algorithm may be used to construct the second classifier.

  Next, the analysis unit 25 generates the first fertilized egg analysis information by applying the second classifier constructed as described above to the second time-lapse image G2 output from the image processing unit 27. Specifically, the first fertilized egg analysis information is generated by performing deep learning analysis on the second time-lapse image G2 using the second discriminator.

  Thereby, the analysis precision of the analysis part 25 at the time of producing | generating the 1st fertilized egg analysis information improves. Then, the analysis unit 25 outputs the first fertilized egg analysis information to the output unit 26 and the storage unit 28, and the first fertilized egg analysis information is stored in the storage unit 28.

  The second time-lapse image G2 described above corresponds to “input data” in FIG. 13, and the first fertilized egg analysis information corresponds to “result” in FIG.

[Step S04: Send evaluation support information]
The output unit 26 generates evaluation support information including at least the identification information acquired from the acquisition unit 24 and the first fertilized egg analysis information acquired from the analysis unit 25. Then, the output unit 26 outputs this evaluation support information to the fertilized egg quality evaluator via the network N.

  The evaluation support information is transmitted to the first terminal 30 as, for example, a “fertilized egg analysis report” for a fertilized egg quality evaluator. The “fertilized egg analysis report” may be displayed on the first terminal 30 via application software for a fertilized egg quality evaluator installed on the first terminal 30. At this time, the first terminal 30 includes, as first fertilized egg analysis information, an imaging time when the imaging unit 2021 images the fertilized egg F, a development time (culture time) of the fertilized egg F, quality information, shape information, and motion information. A fertilized egg analysis report including at least one of compaction information, contraction information, expansion information, and activity suspension information is displayed on the web browser.

  The 1st terminal 30 (reception part 30a) which received evaluation support information displays evaluation support information on a web browser as a WEB dashboard, for example. Thereby, the quality evaluation of the fertilized egg F by the fertilized egg quality evaluator is supported. Specifically, the fertilized egg quality evaluator who evaluated and browsed the evaluation support information (fertilized egg analysis report) displayed on the first terminal 30 receives the fertilized egg evaluation information based on the evaluation support information via the input unit 30b. Input to the first terminal 30.

  Here, the fertilized egg evaluation information of the present embodiment is, for example, a comment from a fertilized egg quality evaluator who has evaluated and browsed the evaluation support information, an ID of a frozen storage straw for freezing and storing the fertilized egg F, or It is a quality evaluation result for a fertilized egg F made by a fertilized egg quality evaluator who browses (finds) the evaluation support information, and is also synonymous in the following description.

  Comments from fertilized egg quality evaluators include, for example, support information on transplantation / pregnancy / birth / breeding for transplanting and breeding fertilized egg F, and nurturing pups born after transplanting and selling them to the market Support information on fattening, feed and shipping (sales).

[Step S05: Transfer of fertilized egg]
In step S05, the evaluation support information (first fertilized egg analysis information and identification information) acquired from the output unit 26 via the network N and the fertilized egg evaluation information input by the fertilized egg quality evaluator are the first. It is transmitted from the terminal 30 to the fertilized egg transplanter. Hereinafter, some application examples of step S05 will be described.

(Application example 1)
The evaluation support information and the fertilized egg evaluation information transmitted to the second terminal 40 are transmitted to the second terminal 40 as, for example, a “fertilized egg analysis / evaluation report” for a fertilized egg transplanter. The “fertilized egg analysis / evaluation report” may be displayed on the second terminal 40 via, for example, application software for a fertilized egg transplanter installed on the second terminal 40.

  The 2nd terminal 40 (reception part 40a) which acquired evaluation support information (1st fertilized egg analysis information and identification information) and fertilized egg evaluation information displays these information on a web browser as a WEB dashboard, for example. Thereby, the fertilized egg transplanter can select a fertilized egg F having a desired quality with reference to the fertilized egg analysis / evaluation report (evaluation support information and fertilized egg evaluation information). The selection work of the fertilized egg F is supported.

  Subsequently, the fertilized egg transplanter obtains an acquisition request for acquiring the fertilized egg F based on the evaluation support information (first fertilized egg analysis information and identification information) displayed on the second terminal 40 and the fertilized egg evaluation information. It inputs into the 2nd terminal 40 via the input part 40b. This acquisition request is, for example, the desired number of acquisitions that the fertilized egg transplanter wants to acquire the fertilized eggs F, information on the shipping / delivery destination of the selected fertilized eggs F, etc. It is synonymous.

  The 2nd terminal 40 to which the acquisition request was input from the fertilized egg transplanter transmits this acquisition request to the acquisition part 24 via the transmission part 40c via the network N. Next, in response to the acquisition unit 24 acquiring the acquisition request from the second terminal 40, the output unit 26 outputs a transfer instruction corresponding to the acquisition request to the first terminal 30 via the network N. This transfer instruction is an instruction that prompts the fertilized egg transplanter to take out the fertilized egg F selected based on the fertilized egg analysis / evaluation report from the well W, and to ship and deliver the fertilized egg F to the fertilized egg transplanter. The same is true in the following description.

  Next, in response to the first terminal 30 receiving the transfer instruction from the output unit 26, the fertilized egg quality evaluator transmits the transfer instruction to the gateway terminal 10a via the network N. The gateway terminal 10 a that has received the transfer command from the first terminal 30 outputs the transfer command to the control recording PC 205.

  The control recording PC 205 to which the transfer instruction is input displays information corresponding to the transfer instruction via the display device 206. Thereby, the transfer instruction according to the acquisition request | requirement of a fertilized egg transplanter is notified to the fertilized egg manager who manages the fertilized egg F. Then, the fertilized egg manager notified of the transfer instruction ships and delivers the fertilized egg F selected by the fertilized egg transplanter based on the acquisition request of the fertilized egg transplanter.

(Application example 2)
The evaluation support information and the fertilized egg evaluation information transmitted to the second terminal 40 are transmitted to the second terminal 40 as, for example, a “fertilized egg sales report” for a fertilized egg transplanter. The “fertilized egg sales report” may be displayed on the second terminal 40 via, for example, application software for a fertilized egg transplanter installed on the second terminal 40.

  The 2nd terminal 40 (reception part 40a) which acquired evaluation support information (1st fertilized egg analysis information and identification information) and fertilized egg evaluation information displays these information on a web browser as a WEB dashboard, for example. On this WEB dashboard, the price given to each of the plurality of fertilized eggs F is displayed based on the first fertilized egg analysis information, identification information, and fertilized egg evaluation information.

  The fertilized egg transplanter sends a purchase request for purchasing the fertilized egg F based on the evaluation support information (first fertilized egg analysis information and identification information) and fertilized egg evaluation information displayed on the second terminal 40 to the input unit 40b. To the second terminal 40. This purchase request is, for example, information such as the desired number of purchases that the fertilized egg transplanter wants to purchase the fertilized eggs F and the purchase amount corresponding to the desired number of purchases, and the same is true in the following description. It is.

  The second terminal 40 to which the purchase request is input from the fertilized egg transplanter transmits the purchase request to the acquisition unit 24 through the transmission unit 40c via the network N. Next, in response to the acquisition unit 24 acquiring a purchase request from the second terminal 40, the output unit 26 transmits a sales command corresponding to the purchase request to the first terminal 30 via the network N. This sales instruction is an instruction to urge the fertilized egg transplanter to take out the fertilized egg F selected based on the fertilized egg sales report from the well W and sell the fertilized egg F to the fertilized egg transplanter.

  Next, in response to the first terminal 30 receiving the sales instruction from the output unit 26, the fertilized egg quality evaluator transmits the sales instruction to the gateway terminal 10a via the network N. Then, the gateway terminal 10 a that has received the sales command from the first terminal 30 outputs the sales command to the control recording PC 205.

  The control recording PC 205 to which the sales command is input displays information corresponding to the sales command via the display device 206. Thereby, the sales instruction according to the purchase request | requirement of a fertilized egg transplanter is notified to the fertilized egg manager who manages the fertilized egg F. Then, the fertilized egg manager notified of the sales instruction ships and delivers the fertilized egg F selected by the fertilized egg transplanter based on the purchase request of the fertilized egg transplanter.

  Next, when the fertilized egg transplanter receives the fertilized egg F selected by the fertilized egg manager, the fertilized egg transplanter pays the fertilized egg quality evaluator based on the purchase request input to the second terminal 40. The payment to the fertilized egg quality evaluator from the fertilized egg transplanter who purchased the fertilized egg F may be made by mail, bank transfer, etc., or for the fertilized egg transplanter installed in the second terminal 40 It may be executed by online payment using a dedicated application.

[Step S06: Obtain Progress Information]
The fertilized egg transplanter transplants the fertilized egg F shipped / delivered from the fertilized egg manager to livestock to give birth and breed. Then, the juveniles born from the livestock are grown to adults and sold to the market. The fertilized egg transplanter, in the process of growing and selling the fertilized egg F transferred from the fertilized egg manager to the adult, based on the evaluation support information (first fertilized egg analysis information and identification information) and the fertilized egg evaluation information, The progress information about the fertilized egg F selected by itself is obtained.

  Next, the fertilized egg transplanter inputs the progress information obtained as described above to the second terminal 40. Thereby, the progress information regarding the fertilized egg F selected by the fertilized egg transplanter is transmitted from the second terminal 40 to the acquisition unit 24 via the network N.

  Then, the acquisition unit 24 that acquired the progress information outputs the progress information to the analysis unit 25, the output unit 26, and the storage unit 28. The output unit 26 that has acquired the progress information from the acquisition unit 24 outputs this progress information to the fertilized egg quality evaluator (first terminal 30). Further, the progress information output to the storage unit 28 is stored in the storage unit 28.

  Here, the acquisition unit 24 of the present embodiment uses, as progress information, transplantation information, reproduction information, fattening regarding the fertilized egg F selected based on evaluation support information (first fertilized egg analysis information and identification information) and fertilized egg evaluation information. At least one of information and meat information is acquired.

  The transplant information is, for example, information relating to the hatching rate, the implantation rate, the pregnancy rate, the conception rate, the miscarriage rate, the birth rate, and the like that can be understood by transplanting the selected fertilized egg F into livestock.

  Reproductive information is, for example, the breeding rate, survival rate, malformation rate, average survival age, prevalence rate, which can be understood by developing the selected fertilized egg F to adults and breeding the same pedigree species with this adult as a parent. This is information about the Rakan rate.

  The fattening information is, for example, information on the weight, body height, and health condition of the adult, which can be understood by growing the selected fertilized egg F to the young and artificially fattening the young to the adult, For example, information about the price when an adult was auctioned.

  The meat information refers to, for example, information on the meat quality grade, yield grade and umami of the above-mentioned meat, which is obtained by growing the selected fertilized egg F to an adult and processing the adult meat, and selling the above-mentioned meat to the market For example, information about the price at the moment.

  The “transplant information”, “breeding information”, “fattening information” and “meat information” listed above have the same meaning in the following description.

  Subsequently, the analysis unit 25 that acquired the progress information from the acquisition unit 24 stores the shape information, the movement information, the compaction information, the contraction information, and the extension information related to the fertilized egg F associated with the progress information stored in the storage unit 28. At least one of activity suspension information, growth information based on findings, quality information, identification information, and culture environment information is read from the storage unit 28.

  Next, the analysis unit 25 reconstructs the discriminator by incorporating the progress information and information read from the storage unit 28 as learning data into a preset algorithm. As a result, the discriminator is updated.

  On the other hand, the progress information is displayed on the first terminal 30 that has acquired the progress information from the output unit 26. That is, progress information on the fertilized egg F selected based on the evaluation support information (first fertilized egg analysis information and identification information) and the fertilized egg evaluation information is notified to the fertilized egg quality evaluator. Thereby, when the fertilized egg quality evaluator evaluates the quality of the fertilized egg F based on the evaluation support information (fertilized egg analysis report), it is possible to perform the quality evaluation considering the progress information.

<Action>
In recent years, the quality of a fertilized egg to be transplanted has become an important factor influencing transplantation results in the field of infertility treatment and livestock production. The selection of fertilized eggs to be transplanted generally involves determining the growth state and quality of the fertilized eggs based on morphological findings using an optical microscope, an image processing apparatus, or the like.

  However, in the quality evaluation of a fertilized egg before transplantation, the morphological evaluation method as described above not only requires skill but also tends to be subjective. For this reason, recently, in selecting a good fertilized egg, it is desired to obtain a quality evaluation result of the fertilized egg that is evaluated with higher accuracy than morphological findings.

  In particular, a large number of fertilized eggs are collected from the uterus of the cow, and excellent fertilized eggs are selected from the many fertilized eggs, and this fertilized egg is placed in the womb of a cow other than the cow from which the fertilized eggs are collected. In the livestock industry where transplantation is often performed, the number of live births of cows is limited, so there are significant adverse effects when adults derived from fertilized eggs selected based on morphological findings do not have the desired quality .

  Therefore, in the recent livestock industry, from the viewpoint of improving the productivity when handling livestock as commodities, the quality evaluation has been analyzed with a higher degree of accuracy of fertilized eggs before transplantation after transplantation. The result is anxious.

  However, in the current livestock industry, in order to obtain a quality evaluation result in which fertilized eggs before transplantation are analyzed with high accuracy, ask a specialized institution or a specialist such as a skilled embryo cultivator. There is a problem that there is a problem in that there is not a hand, and in the case of requesting, it takes more time than necessary to obtain the analysis result, and it is too costly to obtain a fertilized egg of a desired quality.

  In view of such circumstances, in the fertilized egg quality evaluation system 100 according to this embodiment, a plurality of observation images obtained by capturing the fertilized egg F in time series along the culture time are analyzed with high accuracy by the specialized AI. The analysis information and the evaluation information evaluated by the fertilized egg quality evaluator can be transmitted to the second terminal 40 of the fertilized egg transplanter.

  Thereby, the fertilized egg transplanter can easily obtain the quality evaluation result regarding the fertilized egg F analyzed and evaluated with much higher accuracy than the quality evaluation method based on the morphological findings, regardless of the place. it can. Therefore, as in the prior art, it is possible not only to save the trouble of requesting a specialized institution or an embryo culturer for quality evaluation of a fertilized egg, but also to cut costs.

  In the fertilized egg quality evaluation system 100, an acquisition request or purchase request based on the evaluation support information (first fertilized egg analysis information and identification information) and the fertilized egg evaluation information is input to the second terminal 40 by the fertilized egg transplanter. The

  Thus, the fertilized egg transplanter can perform fertilization of a desired quality with reference to the analysis result analyzed with high accuracy by the specialized AI and the evaluation information obtained by further evaluating the analysis result by the fertilized egg quality evaluator. Only fertilized eggs that have a high probability of adultizing to high quality livestock after transplantation can be selected and obtained.

  Therefore, not only the efficiency of selecting a fertilized egg that is expected to have high development potential after transplanting is greatly improved, but also the risk of selecting an adult fertilized egg that is not of the desired quality is minimized. .

  Furthermore, in the fertilized egg quality evaluation system 100 according to the present embodiment, the process from the analysis of the observation image of the fertilized egg F until the progress information is transmitted from the fertilized egg transplanter to the information processing apparatus 20 and the first terminal 30 is performed. Complete with one system. Accordingly, the fertilized egg transplanter can transmit an acquisition or purchase request to the information processing apparatus 20 via the second terminal 40 at any time, regardless of the location and time. Therefore, the convenience of selection work in selecting the fertilized egg F is improved.

<< Second Embodiment >>
FIG. 14 is a block diagram of a fertilized egg quality evaluation system 300 according to the second embodiment of the present technology. Hereinafter, the same reference numerals are given to the same configurations as those in the first embodiment, and the detailed description thereof is omitted.

  As shown in FIG. 13, in the fertilized egg quality evaluation system 300 according to this embodiment, the information processing apparatus 20 further includes a determination unit 220, and can communicate with each other via a plurality of second terminals 40 and the network N. It is different from the first embodiment in that it is connected.

  The determination unit 220 according to the present embodiment determines which purchase request is to be satisfied among the purchase requests acquired from each of the plurality of second terminals 40. Detailed functions of the determination unit 220 will be described later.

<Method of evaluating fertilized egg quality>
FIG. 15 is a flowchart showing a method for evaluating the quality of the fertilized egg F in the fertilized egg quality evaluation system 300 according to this embodiment. Hereinafter, a method for evaluating the quality of the fertilized egg F will be described with reference to FIG. Note that description of steps similar to those in the first embodiment is omitted.

  The fertilized egg quality evaluation system 300 according to the present embodiment is a fertilized egg transplant that presents the best purchase conditions based on evaluation support information (first fertilized egg analysis information and identification information) regarding the fertilized egg F and fertilized egg evaluation information. This is an auction system for selling fertilized eggs F to a person. The details will be described below.

[Step S21: Sales Determination]
The fertilized egg quality evaluator transmits evaluation support information (first fertilized egg analysis information and identification information) and fertilized egg evaluation information to each of the plurality of second terminals 40 via the first terminal 30. .

  Each fertilized egg transplanter inputs a purchase request for purchasing the fertilized egg F to the second terminal 40 based on the evaluation support information and the fertilized egg evaluation information displayed on the second terminal 40. In the present embodiment, the purchase request includes, for example, the desired number of purchases such as how many fertilized eggs F are desired to be purchased, the purchase price set by the fertilized egg transplanter based on the evaluation support information and the fertilized egg evaluation information, and the like. 2 is input to the terminal 40.

  The plurality of second terminals 40 to which the purchase request is input from the fertilized egg transplanter transmits the purchase request to the acquisition unit 24 via the network N. The acquisition unit 24 outputs the purchase request acquired from each of the plurality of second terminals 40 to the determination unit 220.

  The determination unit 220 determines which purchase request is to be satisfied among the purchase requests of each of the plurality of second terminals 40 output from the acquisition unit 24. At this time, the determination unit 220 typically accepts only purchase requests from the second terminal 40 of the fertilized egg transplanter who has given the highest purchase price among purchase requests transmitted from the plurality of second terminals 40. The purchase request is output to the output unit 26.

[Step S22: Sale of fertilized eggs]
Subsequently, the output unit 26 sends a fertilized egg F that has been auctioned to the sales instruction according to the purchase request from the second terminal 40 of the fertilized egg transplanter permitted to purchase through the network N. It transmits to the 1st terminal 30 of an egg quality evaluator. This sales instruction is an instruction for taking out the fertilized egg F for which the fertilized egg transplanter has made a successful bid from the well W and promoting the sale of the fertilized egg F to the fertilized egg transplanter.

  Next, in response to the first terminal 30 receiving the sales instruction from the output unit 26, the fertilized egg quality evaluator transmits the sales instruction to the gateway terminal 10a via the network N. Then, the gateway terminal 10 a that has received the sales command from the first terminal 30 outputs the sales command to the control recording PC 205.

  The control recording PC 205 to which the sales command is input displays information corresponding to the sales command via the display unit 206. Thereby, the sales instruction according to the purchase request | requirement of a fertilized egg transplanter is notified with respect to the fertilized egg manager who manages the fertilized egg F. FIG. Then, the fertilized egg manager notified of the sales instruction ships and delivers the fertilized egg F for which the fertilized egg transplanter has made a successful bid based on the purchase request of the fertilized egg transplanter permitted to purchase.

  Next, when the fertilized egg transplanter receives the fertilized egg F that he / she has made a successful bid for from the fertilized egg manager, the fertilized egg transplanter pays the fertilized egg quality evaluator the price based on the purchase price set by himself / herself. The payment to the fertilized egg quality evaluator from the fertilized egg transplanter who has made a successful bid for the fertilized egg F may be made by mail or bank transfer, or for the fertilized egg transplanter installed in the second terminal 40 It may be executed by online payment using a dedicated application.

<Action>
The fertilized egg quality evaluation system 300 of this embodiment is based on the evaluation support information (first fertilized egg analysis information and identification information) related to the fertilized egg F and the fertilized egg transplanter who gave the highest value based on the fertilized egg evaluation information. The fertilized egg F is awarded. As a result, the profitability of the fertilized egg quality evaluator when producing the fertilized egg F as a business is dramatically improved.

<Modification>
The fertilized egg quality evaluation system 300 of the present embodiment is configured such that a single first terminal 30 is connected to a plurality of second terminals 40 via a network N as shown in FIG. Not limited.

  For example, a plurality of first and second terminals 30 and 40 may be connected via the network N, and a plurality of first terminals 30 may be connected to a single second terminal 40 via the network N. . Alternatively, each of the single first and second terminals 30 and 40 may be connected via the network N.

<< Third Embodiment >>
FIG. 16 is a block diagram of a fertilized egg quality evaluation system 500 according to the third embodiment of the present technology. Hereinafter, the same reference numerals are given to the same configurations as those in the first embodiment, and the detailed description thereof is omitted.

  A fertilized egg quality evaluation system 500 of this embodiment is different from the first embodiment in that the fertilized egg manager further handles not only the observation device 202 but also the gene analysis device 400, as shown in FIG.

  The gene analyzing apparatus 400 is connected to the control recording PC 205, and is connected to the gateway terminal 10a via the control recording PC 205. That is, the gene analyzing apparatus 400 is connected to the information processing apparatus 20 and the first and second terminals 30 and 40 via the control recording PC 205 and the gateway terminal 10a so as to communicate with each other.

  The gene analysis apparatus 400 of the present embodiment is a gene analysis apparatus that uses, for example, a DNA (deoxyribonucleic acid) chip, or a DNA sequencing method or a PCR (Polymerase Chain Reaction) method, but is not limited thereto.

  The gene analysis information obtained by the gene analyzer 400 analyzing the gene of the fertilized egg F is, for example, A (adenine), T (thymine), G (obtained by SNP (Single Nucleotide Polymorphism) typing. It is information on the sequences of four types of bases (guanine) and C (cytosine), and is also synonymous in the following description.

<Method of evaluating fertilized egg quality>
FIG. 17 is a flowchart showing a method for evaluating the quality of the fertilized egg F of the fertilized egg quality evaluation system 500 according to this embodiment. Hereinafter, the quality evaluation method of the fertilized egg F will be described with reference to FIG. 17 as appropriate. Note that description of steps similar to those in the first embodiment is omitted.

[Step S31: Obtain Observation Image / Identification Information / Genetic Analysis Information]
First, identification information regarding the fertilized egg F and gene analysis information obtained by the gene analyzing apparatus 400 analyzing the gene of the fertilized egg F are input to the control recording PC 205. The identification information and gene analysis information input to the control record PC 205 are stored in the control record PC 205 and transmitted to the gateway terminal 10a. The gateway terminal 10a that has received the identification information and the gene analysis information transmits these information to the acquisition unit 24 via the network N, and the acquisition unit 24 acquires these information.

  Subsequently, in response to the acquisition unit 24 acquiring the identification information and the gene analysis information from the gateway terminal 10a via the network N, the output unit 26 outputs an imaging command for imaging the fertilized egg F via the network N. To 10a. The gateway terminal 10 a that has received the imaging command transmits this imaging command to the control recording PC 205.

  The control recording PC 205 that has received the imaging command controls the imaging unit 2021 in accordance with the imaging command. Thereby, as described in the first embodiment, the first time-lapse image G1 including six fertilized eggs F is generated, and the first time-lapse image G1 is transmitted to the control recording PC 205.

  The control recording PC 205 to which the first time lapse image G1 is input transmits the first time lapse image G1 to the gateway terminal 10a. The gateway terminal 10a that has received the first time lapse image G1 transmits the first time lapse image G1 to the acquisition unit 24 via the network N, and the acquisition unit 24 acquires the first time lapse image G1.

  The acquisition unit 24 outputs the first time-lapse image G1, the identification information, and the gene analysis information acquired from the gateway terminal 10a via the network N to the storage unit 28, and these are stored in the storage unit 28. In addition, the acquisition unit 24 outputs the acquired first time-lapse image G1 to the image processing unit 27, and also outputs the identification information and gene analysis information to the output unit 26.

[Step S33: Analysis Processing]
Preliminarily stored in the storage unit 28, gene analysis information of fertilized eggs collected from a plurality of fertilized egg managers via the network N, and shape information, movement information, compaction information based on time-lapse images of the fertilized eggs, The analysis unit 25 reads from the storage unit 28 at least one of contraction information, extended information, activity suspension information, growth information based on findings, and quality information. These pieces of information correspond to “learning data” in FIG.

  Next, the analysis unit 25 constructs a discriminator by incorporating the learning data read from the storage unit 28 into a preset algorithm. Thereby, the analysis part 25 becomes a structure which has a discriminator.

  The above-described algorithm corresponds to the “algorithm” of FIG. 13 and functions as a machine learning algorithm as listed in the first embodiment, for example. The classifier corresponds to the “learned model” in FIG.

  Next, the analysis unit 25 analyzes the classifier constructed as described above with respect to the second time-lapse image G2 output from the image processing unit 27 and the gene analysis information related to the fertilized egg F associated with the second time-lapse image G2. Is applied to the second fertilized egg analysis information.

  Specifically, the second time-lapse image and the gene analysis information are subjected to deep learning analysis using a discriminator, thereby generating second fertilized egg analysis information. Then, the analysis unit 25 outputs the second fertilized egg analysis information to the output unit 26 and the storage unit 28, and the second fertilized egg analysis information is stored in the storage unit 28.

  Note that the above-described second time-lapse image G2 and the gene analysis information regarding the fertilized egg F associated with the second time-lapse image G2 correspond to the “input data” in FIG. 13, and the second fertilized egg analysis information is shown in FIG. This corresponds to the “result”.

[Step S34: Send evaluation support information]
The output unit 26 generates evaluation support information including at least the identification information and gene analysis information acquired from the acquisition unit 24 and the second fertilized egg analysis information acquired from the analysis unit 25. Then, the output unit 26 outputs this evaluation support information to the fertilized egg quality evaluator via the network N.

  The evaluation support information is transmitted to the first terminal 30 as, for example, a “fertilized egg analysis report” for a fertilized egg quality evaluator. The “fertilized egg analysis report” may be displayed on the first terminal 30 via, for example, application software for a fertilized egg quality evaluator installed on the first terminal 30.

  The first terminal 30 that has received the evaluation support information displays the evaluation support information on a web browser as a WEB dashboard, for example. Thereby, the quality evaluation of the fertilized egg F by the fertilized egg quality evaluator is supported. Specifically, the fertilized egg evaluation information based on the evaluation support information is input to the first terminal 30 by the fertilized egg quality evaluator who has evaluated and browsed the evaluation support information (fertilized egg analysis report) displayed on the first terminal 30. Is done.

[Step S35: Transfer of fertilized egg]
The first terminal 30 receives the evaluation support information (second fertilized egg analysis information, identification information, and gene analysis information) acquired from the output unit 26 via the network N and the fertilized egg evaluation input by the fertilized egg quality evaluator. Information is transmitted to the second terminal 40.

  These pieces of information transmitted to the second terminal 40 are transmitted to the second terminal 40 as, for example, a “fertilized egg analysis / evaluation report” for a fertilized egg transplanter. The “fertilized egg analysis / evaluation report” may be displayed on the second terminal 40 via, for example, application software for a fertilized egg transplanter installed on the second terminal 40.

  The 2nd terminal 40 which acquired evaluation support information (2nd fertilized egg analysis information, identification information, and gene analysis information) and fertilized egg evaluation information displays such information on a web browser as a WEB dashboard, for example. Thereby, the fertilized egg transplanter can select a fertilized egg F having a desired quality with reference to the fertilized egg analysis / evaluation report (evaluation support information and fertilized egg evaluation information). The selection work of the fertilized egg F is supported.

  Subsequently, the fertilized egg transplanter acquires the fertilized egg F based on the evaluation support information (second fertilized egg analysis information, identification information, and gene analysis information) displayed on the second terminal 40 and the fertilized egg evaluation information. An acquisition request is input to the second terminal 40 via the input unit 40b.

  The 2nd terminal 40 to which the acquisition request was input from the fertilized egg transplanter transmits this acquisition request to the acquisition part 24 via the transmission part 40c via the network N. Next, in response to the acquisition unit 24 acquiring the acquisition request from the second terminal 40, the output unit 26 outputs a transfer instruction corresponding to the acquisition request to the first terminal 30 via the network N.

  Next, in response to the first terminal 30 receiving the transfer instruction from the output unit 26, the fertilized egg quality evaluator transmits the transfer instruction to the gateway terminal 10a via the network N. The gateway terminal 10 a that has received the transfer command from the first terminal 30 outputs the transfer command to the control recording PC 205.

  The control recording PC 205 to which the transfer instruction is input displays information corresponding to the transfer instruction via the display unit 206. Thereby, the transfer instruction according to the acquisition request | requirement of a fertilized egg transplanter is notified to the fertilized egg manager who manages the fertilized egg F. Then, the fertilized egg manager notified of the transfer instruction ships and delivers the fertilized egg F selected by the fertilized egg transplanter based on the acquisition request of the fertilized egg transplanter.

[Step S36: Progress Information Acquisition]
The fertilized egg transplanter transplants the fertilized egg F shipped / delivered from the fertilized egg manager to livestock to give birth and breed. Then, the juveniles born from the livestock are grown to adults and sold to the market. The fertilized egg transplanter, in the process of developing and selling the fertilized egg F transferred from the fertilized egg manager to adults, evaluation support information (second fertilized egg analysis information, identification information and gene analysis information) and fertilized egg evaluation Based on the information, the progress information regarding the fertilized egg F selected by the user is obtained.

  Next, the fertilized egg transplanter inputs the progress information obtained as described above to the second terminal 40. Thereby, the progress information regarding the fertilized egg F selected by the fertilized egg transplanter is transmitted from the second terminal 40 to the acquisition unit 24 via the network N.

  Then, the acquisition unit 24 that acquired the progress information outputs the progress information to the analysis unit 25, the output unit 26, and the storage unit 28. The output unit 26 that has acquired the progress information from the acquisition unit 24 outputs this progress information to the fertilized egg quality evaluator (first terminal 30). Further, the progress information output to the storage unit 28 is stored in the storage unit 28.

  Here, the acquisition unit 24 of the present embodiment, as progress information, transplant information regarding the fertilized egg F selected based on evaluation support information (second fertilized egg analysis information, identification information, and gene analysis information) and fertilized egg evaluation information. At least one of breeding information, fattening information, and meat information is acquired.

  Subsequently, the analysis unit 25 that acquired the progress information from the acquisition unit 24 stores the shape information, the movement information, the compaction information, the contraction information, and the extension information related to the fertilized egg F associated with the progress information stored in the storage unit 28. At least one of activity suspension information, growth information based on findings, quality information, gene analysis information, and culture environment information is read from the storage unit 28.

  Next, the analysis unit 25 reconstructs the discriminator by incorporating the progress information and information read from the storage unit 28 as learning data into a preset algorithm. As a result, the discriminator is updated.

  On the other hand, the progress information is displayed on the first terminal 30 that has acquired the progress information from the acquisition unit 24. That is, progress information on the fertilized egg F selected based on the evaluation support information (second fertilized egg analysis information, identification information, and gene analysis information) and the fertilized egg evaluation information is notified to the fertilized egg quality evaluator. Thereby, when the fertilized egg quality evaluator evaluates the quality of the fertilized egg F based on the evaluation support information (fertilized egg analysis report), it is possible to perform the quality evaluation considering the progress information.

<Action>
In the fertilized egg quality evaluation system 500 according to the present embodiment, an acquisition request based on evaluation support information (second fertilized egg analysis information, identification information, and gene analysis information) and fertilized egg evaluation information is sent by the fertilized egg transplanter to the second terminal. 40.

  Thus, the fertilized egg transplanter can analyze the second time-lapse image G2 and the analysis result obtained by analyzing the gene analysis information related to the fertilized egg F linked to the second time-lapse image G2 with high accuracy by the specialized AI. The fertilized egg F having a desired quality can be selected and obtained with reference to the evaluation information whose analysis result is further evaluated by the fertilized egg quality evaluator and the identification information related to the fertilized egg F.

<< Fourth Embodiment >>
FIG. 18 is a block diagram of a fertilized egg quality evaluation system 700 according to the fourth embodiment of the present technology. Hereinafter, the same reference numerals are given to the same configurations as those in the first and third embodiments, and the detailed description thereof is omitted.

  As shown in FIG. 18, the fertilized egg quality evaluation system 700 of this embodiment differs from the first and third embodiments in that the fertilized egg manager further handles not only the observation device 202 but also the gene editing device 600.

  The gene editing device 600 is connected to the control recording PC 205, and is connected to the gateway terminal 10a via the control recording PC 205. That is, the gene editing device 600 is connected to the information processing device 20 and the first and second terminals 30 and 40 via the control recording PC 205 and the gateway terminal 10a so as to communicate with each other.

  The gene editing device 600 is an arbitrary gene editing tool that edits genome information of the fertilized egg F. As such a gene editing tool, for example, CRISPER / Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats / CRISPR-associated protein 9 ) And the like.

  The gene editing information obtained by the gene editing apparatus 600 editing the gene of the fertilized egg F is, for example, genome editing information obtained by changing the DNA sequence of the fertilized egg F. In the following description, Is also synonymous.

<Method of evaluating fertilized egg quality>
FIG. 19 is a flowchart showing a method for evaluating the quality of the fertilized egg F in the fertilized egg quality evaluation system 700 according to this embodiment. Hereinafter, a method for evaluating the quality of the fertilized egg F will be described with reference to FIG. Note that description of steps similar to those in the first embodiment is omitted.

[Step S41: Obtain observation image / identification information / gene analysis information / gene editing information]
First, identification information and gene analysis information regarding the fertilized egg F, and gene editing information obtained by the gene editing apparatus 600 editing the gene of the fertilized egg F are input to the control recording PC 205. The identification information, gene analysis information, and gene editing information input to the control record PC 205 are stored in the control record PC 205 and transmitted to the gateway terminal 10a. The gateway terminal 10a that has received the identification information, the gene analysis information, and the gene editing information transmits these pieces of information to the acquisition unit 24 via the network N, and the acquisition unit 24 acquires them.

  Subsequently, in response to the acquisition unit 24 acquiring the identification information, the gene analysis information, and the gene editing information from the gateway terminal 10a via the network N, the output unit 26 outputs an imaging command for imaging the fertilized egg F. Via the gateway terminal 10a. The gateway terminal 10 a that has received the imaging command outputs this imaging command to the control recording PC 205.

  The control recording PC 205 that has received the imaging command controls the imaging unit 2021 in accordance with the imaging command. Thereby, as described in the first embodiment, the first time-lapse image G1 including six fertilized eggs F is generated, and the first time-lapse image G1 is transmitted to the control recording PC 205.

  The control recording PC 205 to which the first time lapse image G1 is input transmits the first time lapse image G1 to the gateway terminal 10a. The gateway terminal 10a that has received the first time lapse image G1 transmits the first time lapse image G1 to the acquisition unit 24 via the network N, and the acquisition unit 24 acquires the first time lapse image G1.

  The acquisition unit 24 outputs the first time-lapse image G1, the identification information, the gene analysis information, and the gene editing information acquired from the gateway terminal 10a via the network N to the storage unit 28, and these are stored in the storage unit 28. . In addition, the acquisition unit 24 outputs the acquired first time-lapse image G1 to the image processing unit 27, and also outputs identification information, gene analysis information, and gene editing information to the output unit 26.

[Step S43: Analysis Processing]
Shape information and movement information based on gene analysis information and gene editing information of fertilized eggs collected from a plurality of fertilized egg managers via the network N, and time-lapse images of the fertilized eggs stored in advance in the storage unit 28 The analysis unit 25 reads from the storage unit 28 at least one of compaction information, contraction information, expansion information, activity suspension information, growth information based on findings, and quality information. These pieces of information correspond to “learning data” in FIG.

  Next, the analysis unit 25 constructs a discriminator by incorporating the learning data read from the storage unit 28 into a preset algorithm. Thereby, the analysis part 25 becomes a structure which has a discriminator.

  The above-described algorithm corresponds to the “algorithm” of FIG. 13 and functions as a machine learning algorithm as listed in the first embodiment, for example. The classifier corresponds to the “learned model” in FIG.

  Next, the analysis unit 25 analyzes the classifier constructed as described above with respect to the second time-lapse image G2 output from the image processing unit 27 and the gene analysis information related to the fertilized egg F associated with the second time-lapse image G2. And third fertilized egg analysis information is generated by applying to the gene editing information. Then, the analysis unit 25 outputs the third fertilized egg analysis information to the output unit 26 and the storage unit 28, and the third fertilized egg analysis information is stored in the storage unit 28.

  Note that the second time-lapse image G2 and the gene analysis information and gene editing information regarding the fertilized egg F linked to the second time-lapse image G2 correspond to the “input data” in FIG. Corresponds to the “result” in FIG.

[Step S44: Send Evaluation Support Information]
The output unit 26 generates evaluation support information including at least the identification information, gene analysis information, and gene editing information acquired from the acquisition unit 24 and the third fertilized egg analysis information acquired from the analysis unit 25. Then, the output unit 26 transmits this evaluation support information to the fertilized egg quality evaluator via the network N.

  The evaluation support information is transmitted to the first terminal 30 as, for example, a “fertilized egg analysis report” for a fertilized egg quality evaluator. The “fertilized egg analysis report” may be displayed on the first terminal 30 via, for example, application software for a fertilized egg quality evaluator installed on the first terminal 30.

  The first terminal 30 that has received the evaluation support information displays the evaluation support information on a web browser as a WEB dashboard, for example. Thereby, the quality evaluation of the fertilized egg F by the fertilized egg quality evaluator is supported. Specifically, the fertilized egg evaluation information based on the evaluation support information is input to the first terminal 30 by the fertilized egg quality evaluator who has evaluated and browsed the evaluation support information (fertilized egg analysis report) displayed on the first terminal 30. Is done.

[Step S45: Transfer of fertilized egg]
The first terminal 30 is input via the network N by the evaluation support information (third fertilized egg analysis information, identification information, gene analysis information, and gene editing information) acquired from the output unit 26 and a fertilized egg quality evaluator. The fertilized egg evaluation information is transmitted to the second terminal 40.

  These pieces of information transmitted to the second terminal 40 are transmitted to the second terminal 40 as, for example, a “fertilized egg analysis / evaluation report” for a fertilized egg transplanter. The “fertilized egg analysis / evaluation report” may be displayed on the second terminal 40 via, for example, application software for a fertilized egg transplanter installed on the second terminal 40.

  The second terminal 40 that has acquired the evaluation support information (third fertilized egg analysis information, identification information, gene analysis information, and gene editing information) and the fertilized egg evaluation information, for example, displays these information on a web browser as a WEB dashboard. indicate. As a result, a fertilized egg transplanter can select a fertilized egg having a desired quality with reference to a fertilized egg analysis / evaluation report (evaluation support information and fertilized egg evaluation information). Egg selection work is supported.

  Subsequently, the fertilized egg transplanter performs fertilization based on the evaluation support information (third fertilized egg analysis information, identification information, gene analysis information, and fertilized egg editing information) displayed on the second terminal 40 and the fertilized egg evaluation information. An acquisition request for acquiring the egg F is input to the second terminal 40 via the input unit 40b.

  The second terminal 40 to which the acquisition request is input from the fertilized egg transplanter transmits this acquisition request to the acquisition unit 24 via the network N. Next, in response to the acquisition unit 24 acquiring the acquisition request from the second terminal 40, the output unit 26 transmits a transfer instruction corresponding to the acquisition request to the first terminal 30 via the network N.

  Next, in response to the first terminal 30 receiving the transfer instruction from the output unit 26, the fertilized egg quality evaluator transmits the transfer instruction to the gateway terminal 10a via the network N. The gateway terminal 10 a that has received the transfer command from the first terminal 30 outputs the transfer command to the control recording PC 205.

  The control recording PC 205 to which the transfer instruction is input displays information corresponding to the transfer instruction via the display unit 206. Thereby, the transfer instruction according to the acquisition request | requirement of a fertilized egg transplanter is notified to the fertilized egg manager who manages the fertilized egg F. Then, the fertilized egg manager notified of the transfer instruction ships and delivers the fertilized egg F selected by the fertilized egg transplanter based on the acquisition request of the fertilized egg transplanter.

[Step S46: Obtain Progress Information]
The fertilized egg transplanter transplants the fertilized egg F shipped / delivered from the fertilized egg manager to livestock to give birth and breed. Then, the juveniles born from the livestock are grown to adults and sold to the market. The fertilized egg transplanter, in the process of developing and selling the fertilized egg F transferred from the fertilized egg manager to adults, evaluation support information (third fertilized egg analysis information, identification information, gene analysis information and gene editing information) And the progress information on the fertilized egg F selected by itself is obtained based on the fertilized egg evaluation information.

  Next, the fertilized egg transplanter inputs the progress information obtained as described above to the second terminal 40. Thereby, the progress information regarding the fertilized egg F selected by the fertilized egg transplanter is transmitted from the second terminal 40 to the acquisition unit 24 via the network N.

  Then, the acquisition unit 24 that acquired the progress information outputs the progress information to the analysis unit 25, the output unit 26, and the storage unit 28. The output unit 26 that has acquired the progress information from the acquisition unit 24 transmits this progress information to the fertilized egg quality evaluator (first terminal 30). Further, the progress information output to the storage unit 28 is stored in the storage unit 28.

  Here, the acquisition unit 24 of the present embodiment uses, as progress information, a fertilized egg F selected based on evaluation support information (third fertilized egg analysis information, identification information, gene analysis information, and gene editing information) and fertilized egg evaluation information. At least one of transplant information, breeding information, fattening information, and meat information.

  Subsequently, the analysis unit 25 that acquired the progress information from the acquisition unit 24 stores the shape information, the movement information, the compaction information, the contraction information, and the extension information related to the fertilized egg F associated with the progress information stored in the storage unit 28. At least one of activity stop information, growth information based on findings, quality information, gene analysis information, gene editing information, and culture environment information is read from the storage unit 28.

  Next, the analysis unit 25 reconstructs the discriminator by incorporating the progress information and information read from the storage unit 28 as learning data into a preset algorithm. As a result, the discriminator is updated.

  On the other hand, the progress information is displayed on the first terminal 30 that has acquired the progress information from the acquisition unit 24. That is, progress information regarding the fertilized egg F selected based on the evaluation support information (third fertilized egg analysis information, identification information, gene analysis information, and gene editing information) and the fertilized egg evaluation information is notified to the fertilized egg quality evaluator. . Thereby, when the fertilized egg quality evaluator evaluates the quality of the fertilized egg F based on the evaluation support information (fertilized egg analysis report), it is possible to perform the quality evaluation considering the progress information.

<Action>
In the fertilized egg quality evaluation system 700 according to the present embodiment, an acquisition request based on evaluation support information (third fertilized egg analysis information, identification information, gene analysis information, and gene editing information) and fertilized egg evaluation information by a fertilized egg transplanter. Is input to the second terminal 40.

  As a result, the fertilized egg transplanter can analyze the second time-lapse image G2 and the gene analysis information and gene editing information on the fertilized egg F linked to the second time-lapse image G2 with high accuracy by the specialized AI. The fertilized egg F having a desired quality can be selected and obtained by referring to the result, evaluation information obtained by further evaluating the analysis result by the fertilized egg quality evaluator, and the identification information regarding the fertilized egg F.

<< Fifth Embodiment >>
FIG. 20 is a block diagram of a fertilized egg quality evaluation system 800 according to the fifth embodiment of the present technology. FIG. 21 is a diagram showing an outline of fertilized egg analysis support of the fertilized egg quality evaluation system 800, and shows a flow from analyzing the quality of the fertilized egg F to obtaining progress information regarding the fertilized egg. Hereinafter, the same reference numerals are given to the same configurations as those in the first embodiment, and the detailed description thereof is omitted.

  A fertilized egg quality evaluation system 800 according to the present embodiment includes a fertility treatment clinic or hospital (fertilized egg manager) that cultures and manages a human fertilized egg, and a doctor, embryo culture person or staff belonging to the fertility treatment clinic or hospital. (Fertilized egg quality evaluator) and fertilized eggs analyzed with high precision between fertility clinics and hospitals (fertilized egg transplanters) that transplant human fertilized eggs that have been evaluated for fertility treatment It is a network system that can mutually obtain egg quality evaluation information via a network such as the Internet. Hereinafter, a method for evaluating the quality of a fertilized egg for a human fertilized egg will be described.

<Method of evaluating fertilized egg quality>
FIG. 22 is a flowchart showing a method for evaluating the quality of the fertilized egg F in the fertilized egg quality evaluation system 800 according to this embodiment. Hereinafter, the quality evaluation method of the fertilized egg F will be described with reference to FIG. 22 as appropriate. Note that description of steps similar to those in the first embodiment is omitted.

[Step S51: Obtain Observation Image / Observation Information]
First, a fertilized egg quality evaluator inputs observation information about the fertilized egg F to the control recording PC 205 via the input unit 207. The finding information input to the control recording PC 205 is stored in the control recording PC 205 and transmitted to the gateway terminal 10a. The gateway terminal 10a that has received the finding information transmits the finding information to the obtaining unit 24 via the network N, and the obtaining unit 24 obtains the finding information.

  Here, the finding information of the present embodiment refers to, for example, the quality of the fertilized egg F determined by a doctor or an expert such as an embryo cultivator based on a time-lapse image obtained by imaging the fertilized egg F in time series. This is information on (growth state, number of cells, cell symmetry, number of pronuclei, number of polar bodies, number of nuclei in cell blastomere, fragments, etc.).

  Subsequently, when the acquisition unit 24 acquires the finding information from the gateway terminal 10a via the network N, the output unit 26 transmits an imaging command for imaging the fertilized egg F to the gateway terminal 10a via the network N. . The gateway terminal 10 a that has received the imaging command transmits this imaging command to the control recording PC 205.

  The control recording PC 205 that has received the imaging command controls the imaging unit 2021 in accordance with the imaging command. Thereby, as described in the first embodiment, the first time-lapse image G1 including six fertilized eggs F is generated, and the first time-lapse image G1 is transmitted to the control recording PC 205.

  The control recording PC 205 to which the first time lapse image G1 is input transmits the first time lapse image G1 to the gateway terminal 10a. The gateway terminal 10a that has received the first time lapse image G1 transmits the first time lapse image G1 to the acquisition unit 24 via the network N, and the acquisition unit 24 acquires the first time lapse image G1.

  The acquisition unit 24 outputs the first time-lapse image G1 and the finding information acquired from the gateway terminal 10a via the network N to the storage unit 28, and these are stored in the storage unit 28. In addition, the acquisition unit 24 outputs the acquired first time-lapse image G1 to the image processing unit 27 and also outputs the finding information to the output unit 26.

[Step S54: Send evaluation support information]
The output unit 26 generates evaluation support information including at least the finding information acquired from the acquiring unit 24 and the first fertilized egg analysis information acquired from the analyzing unit 25. Then, the output unit 26 outputs this evaluation support information to the fertilized egg quality evaluator via the network N.

  The evaluation support information is transmitted to the first terminal 30 as, for example, a “fertilized egg analysis report” for a fertilized egg quality evaluator. The “fertilized egg analysis report” may be displayed on the first terminal 30 via, for example, application software for a fertilized egg quality evaluator installed on the first terminal 30.

  The first terminal 30 that has received the evaluation support information displays the evaluation support information on a web browser as a WEB dashboard, for example. Thereby, the quality evaluation of the fertilized egg F by the fertilized egg quality evaluator is supported. Specifically, fertilized egg evaluation information based on the evaluation support information is input to the first terminal 30 by a fertilized egg quality evaluator who has evaluated and browsed the evaluation support information displayed on the first terminal 30.

  Note that the fertilized egg quality evaluation system 800 according to the present embodiment is a network system that complies with “Guidelines on Safety Management of Medical Information Systems” (so-called three guidelines and four guidelines). Therefore, the act of the fertilized egg quality evaluator inputting the fertilized egg evaluation information to the first terminal 30 based on the evaluation support information does not correspond to the “diagnosis act” of examining the patient.

[Step S55: embryo transfer]
The first terminal 30 receives the evaluation support information (first fertilized egg analysis information and finding information) acquired from the output unit 26 via the network N and the fertilized egg evaluation information input by the fertilized egg quality evaluator as the second information. Transmit to the terminal 40.

  These pieces of information transmitted to the second terminal 40 are transmitted to the second terminal 40 as, for example, a “fertilized egg analysis / evaluation report” provided for a fertilized egg transplanter. The “fertilized egg analysis / evaluation report” may be displayed on the second terminal 40 via, for example, application software for a fertilized egg transplanter installed on the second terminal 40.

  The 2nd terminal 40 which acquired evaluation support information (1st fertilized egg analysis information and finding information) and fertilized egg evaluation information displays such information on a web browser as a WEB dashboard, for example. As a result, for example, fertilized egg analysis / evaluation reports are reported to infertile patients who go to fertilized egg transplanters (infertility treatment clinics, hospitals, etc.). Useful for planning and managing outpatient and medication schedules.

  Subsequently, doctors belonging to the fertilized egg transplanter refer to the evaluation support information (first fertilized egg analysis information and observation information) and fertilized egg evaluation information displayed on the second terminal 40, and the infertile patient Diagnosis and counseling for transplantation of fertilized egg F At this time, for example, fertilized among a plurality of fertilized eggs F generated by in vitro fertilization of an infertile egg and a partner sperm or a partner egg and an infertile sperm managed by a fertilized egg manager With reference to the egg analysis / evaluation report (evaluation support information and fertilized egg evaluation information), a fertilized egg F having a quality desired by an infertile patient is selected.

  Next, a doctor or the like belonging to the fertilized egg transplanter inputs an acquisition request for acquiring the fertilized egg F selected as a result of diagnosis / counseling with an infertile patient to the second terminal 40. The second terminal 40 to which the acquisition request is input transmits this acquisition request to the gateway terminal 10a via the network N. Then, the gateway terminal 10 a that has received the acquisition request from the second terminal 40 outputs the acquisition request to the control recording PC 205.

  The control recording PC 205 to which the acquisition request is input displays information corresponding to the acquisition request via the display device 206. As a result, the fertilized egg manager who manages the fertilized egg F is notified of the acquisition request of the fertilized egg transplanter. The fertilized egg manager notified of the acquisition request then ships and transports the fertilized egg F selected by the fertilized egg transplanter based on the acquisition request of the fertilized egg transplanter.

  Next, the fertilized egg transplanter receives the fertilized egg F selected as a result of diagnosis and counseling based on the fertilized egg analysis / evaluation report from the fertilized egg manager, and transplants the fertilized egg F into the uterus of the infertile patient.

[Step S56: Obtain Progress Information]
The fertilized egg transplanter is selected based on the fertilized egg analysis / evaluation report (evaluation support information and fertilized egg evaluation information) until the fertilized egg F transplanted into the uterus of an infertile patient develops and gives birth. Obtain progress information about egg F.

  Next, a doctor or the like belonging to the fertilized egg transplanter inputs the progress information obtained as described above to the second terminal 40. Thereby, the progress information regarding the fertilized egg F selected by the fertilized egg transplanter is transmitted from the second terminal 40 to the acquisition unit 24 via the network N.

  Then, the acquisition unit 24 that acquired the progress information outputs the progress information to the analysis unit 25, the output unit 26, and the storage unit 28. The output unit 26 that has acquired the progress information from the acquisition unit 24 transmits this progress information to the fertilized egg quality evaluator (first terminal 30). Further, the progress information output to the storage unit 28 is stored in the storage unit 28.

  Here, the acquisition unit 24 of the present embodiment acquires at least transplantation information related to the fertilized egg F selected based on the evaluation support information (first fertilized egg analysis information and finding information) and the fertilized egg evaluation information as progress information. .

  Subsequently, the analysis unit 25 that acquired the progress information from the acquisition unit 24 stores the shape information, the movement information, the compaction information, the contraction information, and the extension information related to the fertilized egg F associated with the progress information stored in the storage unit 28. At least one of activity suspension information, growth information based on findings, quality information, gene analysis information, and culture environment information is read from the storage unit 28.

  Next, the analysis unit 25 reconstructs the discriminator by incorporating the progress information and information read from the storage unit 28 as learning data into a preset algorithm. As a result, the discriminator is updated.

  On the other hand, the progress information is displayed on the first terminal 30 that has acquired the progress information from the acquisition unit 24. That is, progress information on the fertilized egg F selected based on the evaluation support information (first fertilized egg analysis information and finding information) and the fertilized egg evaluation information is notified to the fertilized egg quality evaluator. Thereby, when the fertilized egg quality evaluator evaluates the quality of the fertilized egg F based on the evaluation support information (fertilized egg analysis report), it is possible to perform the quality evaluation considering the progress information.

<Action>
In the fertilized egg quality evaluation system 800 of the present embodiment, an analysis result obtained by analyzing the second time-lapse image G2 with high accuracy by the specialized AI, and evaluation information obtained by further evaluating the analysis result by the fertilized egg quality evaluator The fertilized egg F having the quality desired by the infertile patient can be selected with reference to the findings information regarding the fertilized egg F linked to the second time-lapse image G2, and the fertilized egg F can be transplanted to the infertile patient.

<Supplement>
FIG. 23 is a diagram illustrating another outline of fertilized egg analysis support of the fertilized egg quality evaluation system 800, and is a diagram illustrating a flow from analyzing the quality of the fertilized egg F to obtaining progress information regarding the fertilized egg. .

  As shown in FIG. 23, the fertilized egg quality evaluation system 800 according to the present embodiment includes a fertilized egg quality evaluator who evaluates the quality of the fertilized egg F and a fertilized egg transplanter who transplants the fertilized egg F. Or an infertility treatment clinic). That is, in the fertilized egg quality evaluation system 800, the management of the fertilized egg F and the transplantation to an infertile patient may be performed at the same organization (a hospital or an infertility treatment clinic). Thereby, since the process of shipping and transporting the fertilized egg F to the fertilized egg transplanter is omitted, the fertilized egg F can be rapidly transplanted to an infertile patient.

<Modification>
In step S51 of the fertilized egg quality evaluation system 800 of the present embodiment, finding information is input to the control recording PC 205 via the input unit 207. However, the present invention is not limited to this, and the identification information described in the first embodiment is not limited to this. It may be further input. That is, even if the evaluation support information including at least the first fertilized egg analysis information, the fertilized egg evaluation information, the finding information, and the identification information is presented to the fertilized egg transplanter or the patient via the second terminal 40. Good.

  As mentioned above, although embodiment of this technique was described, this technique is not limited to the above-mentioned embodiment, Of course, a various change can be added.

  For example, in the fertilized egg quality evaluation system 100, 300, 500, 700, 800, there is an imaging process for imaging the fertilized egg F at any given time, for example, every predetermined period such as every 15 minutes or every other day, or continuously. Repeatedly, the quality of the fertilized egg F is evaluated using the image acquired by this process, but is not limited thereto.

  In the fertilized egg quality evaluation system 100, 300, 500, 700, 800 according to the present embodiment, images may be acquired in real time as necessary, and fertilized by the display device 206 or the first and second terminals 30, 40. An image of the egg F may be displayed and observed and evaluated as needed.

  In the first, third, and fourth embodiments, in response to the acquisition unit 24 acquiring an acquisition request (purchase request) from a fertilized egg transplanter, transfer according to the acquisition request (purchase request) is performed. The command (sales command) is transmitted to the first terminal 30, but is not limited to this.

  For example, in response to the acquisition unit 24 acquiring an acquisition request (purchase request) from the second terminal 40, the output unit 26 sends a transfer instruction (sales instruction) in response to the acquisition request (purchase request) to the terminal device 10. The fertilized egg F may be shipped / delivered by outputting to the fertilized egg manager.

  Further, in the first, third, and fourth embodiments, the acquisition request (purchase request) input to the second terminal 40 is output to the information processing apparatus 20, but the present invention is not limited to this, and the acquisition request (purchase request) ) May be directly output to the fertilized egg manager via the terminal device 10 so that the fertilized egg F may be shipped and delivered.

  In addition, the fertilized egg F targeted by the fertilized egg quality evaluation system 100, 300, 500, 700 according to the present technology is typically derived from cattle, but is not limited thereto, for example, mouse, pig, dog Alternatively, it may be collected from a cat or the like.

  In this specification, “fertilized egg” at least conceptually includes a single cell and an aggregate of a plurality of cells. This single or multiple cell population includes oocytes, eggs (egg / ovum), fertile ovum / zygote, blastocysts, embryos , Associated with cells observed at one or more stages in embryonic development.

  Furthermore, this technology is extracted from living organisms such as unfertilized egg cells (eggs) and embryos of living organisms in the field of livestock, stem cells, immune cells, cancer cells, etc. in the fields of regenerative medicine, pathological biology and gene editing technology. It can also be applied to arbitrary cells such as biological samples.

  In addition, this technique can also take the following structures.

(1)
Obtain time-lapse images of fertilized eggs from producers over the network,
The first fertilized egg analysis information is generated by applying the time-lapse image of the fertilized egg to the learned model generated using the time-lapse image of the fertilized egg collected from a plurality of producers,
A fertilized egg quality evaluation method for outputting the fertilized egg analysis report via the network to an embryo cultivator or producer who evaluates a fertilized egg using the fertilized egg analysis report including the first fertilized egg analysis information.
(2)
The fertilized egg quality evaluation method according to (1) above,
The step of generating the first fertilized egg analysis information includes generating the first fertilized egg analysis information by performing deep learning analysis on the time-lapse image of the fertilized egg using the learned model.
(3)
The fertilized egg quality evaluation method according to (1) or (2) above,
Send fertilized egg sales report to breeders. Fertilized egg quality evaluation method.
(4)
The fertilized egg quality evaluation method according to any one of (1) to (3) above,
The step of outputting the fertilized egg analysis report includes an imaging time when the fertilized egg is imaged, a development time of the fertilized egg, quality information, shape information, movement information, compaction information, contraction information, and extended information. A fertilized egg quality evaluation method for outputting the fertilized egg analysis report including at least one of the activity suspension information as the first fertilized egg analysis information.
(5)
The fertilized egg quality evaluation method according to any one of (1) to (4) above,
In the step of generating the first fertilized egg analysis information, the first discriminator generated based on the first algorithm using the time-lapse images of the fertilized eggs collected from the plurality of producers as learning data is used for fertilization. A fertilized egg quality evaluation method that generates the first fertilized egg analysis information by applying a time-lapse image of an egg.
(6)
The fertilized egg quality evaluation method according to (5), further comprising:
Before generating the first fertilized egg analysis information, normalize the time-lapse image of the fertilized egg,
The step of generating the first fertilized egg analysis information includes generating the first fertilized egg analysis information by applying a time-lapse image of the normalized fertilized egg to the first discriminator. Method.
(7)
The fertilized egg quality evaluation method according to (5) or (6) above,
The step of generating the first fertilized egg analysis information includes a second algorithm generated based on the second algorithm using the time-lapse images of the fertilized eggs collected from the plurality of producers as the learning data and the first algorithm. A method for evaluating fertilized egg quality, comprising: generating the first fertilized egg analysis information by applying a time-lapse image of a fertilized egg to the discriminator of 2;
(8)
The fertilized egg quality evaluation method according to any one of (1) to (7) above,
The step of generating the first fertilized egg analysis information includes a time lapse of a fertilized egg in a discriminator generated based on an algorithm using time-lapse images of fertilized eggs collected from the plurality of producers and identification information as learning data. A fertilized egg quality evaluation method comprising generating the first fertilized egg analysis information by applying an image and identification information.
(9)
The fertilized egg quality evaluation method according to any one of (1) to (8) above,
The step of generating the first fertilized egg analysis information includes a discriminator generated based on an algorithm that uses time-lapse images and culture environment information collected from the plurality of producers as learning data. A fertilized egg quality evaluation method, comprising: generating the first fertilized egg analysis information by applying a time-lapse image and culture environment information.
(10)
The fertilized egg quality evaluation method according to any one of (1) to (9) above,
In the step of generating the first fertilized egg analysis information, as the first fertilized egg analysis information, an imaging time when the fertilized egg is imaged, a development time of the fertilized egg, quality information, shape information, and motion information And at least one of compaction information, contraction information, extended information, and activity suspension information is generated.
(11)
The fertilized egg quality evaluation method according to any one of (3) to (10) above,
The step of transmitting the fertilized egg sales report includes the fertilized egg including evaluation support information that includes the first fertilized egg analysis information and supports quality evaluation of the fertilized egg, and fertilized egg evaluation information based on the evaluation support information A method for evaluating fertilized egg quality by sending a sales report to the breeding company.
(12)
The fertilized egg quality evaluation method according to any one of (3) to (11) above,
Obtain an acquisition request for obtaining a fertilized egg from the breeding company via the network,
A fertilized egg quality evaluation method for outputting a command in accordance with the acquisition request to the producer or the embryo culture person.
(13)
The fertilized egg quality evaluation method according to any one of (3) to (11) above,
A purchase request for purchasing a fertilized egg is obtained from the breeding company via the network,
A fertilized egg quality evaluation method for outputting a command according to the purchase request to the producer or the embryo culturer.
(14)
The fertilized egg quality evaluation method according to (13), further comprising:
A fertilized egg quality evaluation method for determining whether or not the purchase request from the breeding company is met.
(15)
The fertilized egg quality evaluation method according to any one of (3) to (14) above,
Gene analysis information obtained by a gene analyzer for analyzing a fertilized egg gene is obtained from the producer through the network,
Based on the time-lapse image of the fertilized egg and the gene analysis information, the second fertilized egg analysis information is generated,
A fertilized egg quality evaluation method for outputting the second fertilized egg analysis information to the embryo cultivator or the producer via the network.
(16)
The fertilized egg quality evaluation method according to (15), further comprising:
Gene editing information acquired by a gene editing device that edits the gene of a fertilized egg is acquired from the producer through the network,
Based on the time-lapse image of the fertilized egg, the gene analysis information, and the gene editing information, the third fertilized egg analysis information is generated,
A fertilized egg quality evaluation method for outputting the third fertilized egg analysis information to the embryo cultivator or the producer via the network.
(17)
The fertilized egg quality evaluation method according to any one of (3) to (16) above,
Through the network, obtain progress information about fertilized eggs from the breeding company,
A fertilized egg quality evaluation method for outputting the progress information to the producer or the embryo culture person via the network.
(18)
The fertilized egg quality evaluation method according to (17) above,
The step of acquiring the progress information includes acquiring at least one of transplant information, fertilization information, fattening information, and meat information relating to a fertilized egg as the progress information.
(19)
A fertilized egg quality evaluation system including an information processing device for performing quality evaluation of a fertilized egg by cloud computing,
An acquisition unit that acquires a plurality of observation images in which a fertilized egg associated with unique identification information is captured in time series from a terminal device via a network;
Based on the plurality of observation images, an analysis unit that generates fertilized egg analysis information;
An output unit that outputs evaluation support information including the identification information and the fertilized egg analysis information to a computer that receives input of fertilized egg evaluation information based on the evaluation support information via the network. A fertilized egg quality evaluation system.
(20)
The fertilized egg quality evaluation system according to (19) above,
A fertilized egg quality evaluation system, further comprising the terminal device configured to be capable of transmitting the plurality of observation images via the network.
(21)
The fertilized egg quality evaluation system according to (19) or (20) above,
The acquisition unit receives, as the identification information, at least one of information on a sperm and an egg to be a fertilized egg, mating information on a fertilized egg, and information on a culture container in which the fertilized egg is cultured from the terminal device via the network. To obtain more fertilized egg quality evaluation system.
(22)
The fertilized egg quality evaluation system according to any one of (19) to (21) above,
The information processing apparatus is a web server, a fertilized egg quality evaluation system.
(23)
A fertilized egg quality evaluation system including a cloud server that can be connected to a plurality of terminals via a network,
An acquisition unit that acquires a plurality of observation images in which time-series images of fertilized eggs associated with unique identification information are acquired from the terminal via the network;
Based on the plurality of observation images, an analysis unit that generates fertilized egg analysis information;
An output unit that outputs evaluation support information including the identification information and the fertilized egg analysis information to a computer that receives input of fertilized egg evaluation information based on the evaluation support information, via the network; A fertilized egg quality evaluation system.
(24)
Obtaining a time-lapse image of a fertilized egg from a producer via a network;
Generating fertilized egg analysis information by applying the time-lapse image of the fertilized egg to a learned model generated using a time-lapse image of the fertilized egg collected from a plurality of producers;
Causing an information processing apparatus to execute the step of outputting the fertilized egg analysis report via the network to an embryo culturer or producer who evaluates the fertilized egg using the fertilized egg analysis report including the fertilized egg analysis information. program.
(25)
An acquisition unit that acquires a time-lapse image of a fertilized egg from a producer via a network;
An analysis unit that generates fertilized egg analysis information by applying the time-lapse image of the fertilized egg to a learned model generated using the time-lapse image of the fertilized egg collected from a plurality of producers;
An information processing apparatus comprising: an output unit that outputs the fertilized egg analysis report via the network to an embryo culturer or producer who evaluates the fertilized egg using the fertilized egg analysis report including the fertilized egg analysis information .

DESCRIPTION OF SYMBOLS 10 ... Terminal device 10a ... Gateway terminal 20 ... Information processing device 24 ... Acquisition part 25 ... Analysis part 26 ... Output part 27 ... Image processing part 28 ... Memory | storage part 30 ... 1st terminal 40 ... 2nd terminal 202 ... Observation apparatus 220 ... Determination part 400 ... Gene analysis apparatus 500 ... Gene editing apparatus 100,300,500,700,800 ...・ Fertilized egg quality evaluation system F ・ ・ ・ Fertilized egg

Claims (27)

A fertilized egg quality evaluation system including an information processing device for performing quality evaluation of a fertilized egg by cloud computing,
The information processing apparatus includes:
An acquisition unit that acquires identification information and time-lapse images of fertilized eggs from a producer through a network;
A time-lapse image of each fertilized egg linked to the identification information is applied to a learned model generated using learning data including a time-lapse image of a fertilized egg and movement information based on the time-lapse image of the fertilized egg. An analysis unit that generates fertilized egg analysis information for each fertilized egg,
An output unit that outputs evaluation support information including fertilized egg analysis information for each fertilized egg associated with the identification information and the identification information to the embryo cultivator or producer via the network;
Have
The evaluation support information is information displayed on a web browser capable of receiving fertilized egg evaluation information for each fertilized egg input by the embryo cultivator or the producer based on the evaluation support information. Quality evaluation system. The fertilized egg quality evaluation system according to claim 1,
The fertilized egg quality evaluation system , wherein the motion information is a total value of motion velocity vectors in a fertilized egg cell . The fertilized egg quality evaluation system according to claim 1,
The evaluation support information is a fertilized egg quality evaluation system which is information displayed on a web dashboard . The fertilized egg quality evaluation system according to claim 1 ,
The fertilized egg evaluation information is a fertilized egg quality evaluation system including information relating to shipment of the fertilized egg. The fertilized egg quality evaluation system according to claim 1,
A terminal device configured to transmit a time-lapse image of a fertilized egg via the network;
  Fertilized egg quality evaluation system. The fertilized egg quality evaluation system according to claim 1,
  The acquisition unit acquires, as the identification information, at least one of information on a sperm to be a fertilized egg and an egg, mating information on a fertilized egg, or information on a culture container for culturing a fertilized egg via the network.
  Fertilized egg quality evaluation system. A fertilized egg quality evaluation system according to claim 6,
  The mating information is at least one of information on a male from which the sperm has been collected or information on a female from which the egg has been collected.
  Fertilized egg quality evaluation system. A fertilized egg quality evaluation system according to claim 6,
  The information about the culture container is at least one of information about the arrangement of the culture container or information about the arrangement of a fertilized egg.
  Fertilized egg quality evaluation system. The fertilized egg quality evaluation system according to claim 1,
  The information processing apparatus is a web server
  Fertilized egg quality evaluation system. The fertilized egg quality evaluation system according to claim 1,
  The learning data further includes at least one of fertilized egg quality information, fertilized egg shape information, fertilized egg compaction information, fertilized egg contraction information, fertilized egg expansion information, or fertilized egg activity pause information.
  Fertilized egg quality evaluation system. The fertilized egg quality evaluation system according to claim 1,
  The analysis unit generates the fertilized egg analysis information by applying the time-lapse image of the fertilized egg to a discriminator generated based on an algorithm using at least a time-lapse image of the fertilized egg collected from the producer as learning data. Do
  Fertilized egg quality evaluation system. The fertilized egg quality evaluation system according to claim 11,
  The information processing apparatus further includes an image processing unit that normalizes a time-lapse image of a fertilized egg before generating the fertilized egg analysis information,
  The analysis unit generates the fertilized egg analysis information by applying a time-lapse image of the normalized fertilized egg to the discriminator.
  Fertilized egg quality evaluation system. The fertilized egg quality evaluation system according to claim 1,
  The analysis unit applies the time-lapse image and identification information of the fertilized egg to a classifier generated based on an algorithm using the time-lapse image and identification information of the fertilized egg collected from the producer as learning data. Generate egg analysis information
  Fertilized egg quality evaluation system. The fertilized egg quality evaluation system according to claim 1,
  By applying the time-lapse image of the fertilized egg and the culture environment information to the discriminator generated based on the algorithm using the time-lapse image of the fertilized egg collected from the producer and the culture environment information as learning data, the analysis unit, Generate the fertilized egg analysis information
  Fertilized egg quality evaluation system. The fertilized egg quality evaluation system according to claim 1,
  The analysis unit, as the fertilized egg analysis information, imaging time of imaging the fertilized egg, growth time of the fertilized egg, quality information of the fertilized egg, shape information of the fertilized egg, movement information of the fertilized egg, compaction information of the fertilized egg, Generate at least one of contraction information of a fertilized egg, extended information of a fertilized egg, or information on pause of activity of a fertilized egg
  Fertilized egg quality evaluation system. A fertilized egg quality evaluation system according to claim 5,
  The terminal outputs fertilized egg sales information including evaluation support information including the fertilized egg analysis information and supporting quality evaluation of the fertilized egg and fertilized egg evaluation information based on the evaluation support information to a breeding operator.
  Fertilized egg quality evaluation system. A fertilized egg quality evaluation system according to claim 5,
  The acquisition unit acquires an acquisition request for acquiring a fertilized egg from a breeding company via the network,
  The output unit outputs a command corresponding to the acquisition request to the producer or the embryo cultivator.
  Fertilized egg quality evaluation system. A fertilized egg quality evaluation system according to claim 5,
  The acquisition unit acquires a purchase request for purchasing a fertilized egg from a breeding company via the network,
  The output unit outputs a command according to the purchase request to the producer or the embryo culture person.
  Fertilized egg quality evaluation system. The fertilized egg quality evaluation system according to claim 18,
  The information processing apparatus further includes a determination unit that determines whether or not to respond to the purchase request from the breeding company.
  Fertilized egg quality evaluation system. A fertilized egg quality evaluation system according to claim 5,
  The acquisition unit acquires progress information about a fertilized egg from a breeding company via the network,
  The output unit outputs the progress information to the producer or the embryo culture person via the network.
  Fertilized egg quality evaluation system. The fertilized egg quality evaluation system according to claim 20,
  The acquisition unit acquires at least one of transplant information, fertilization information, fattening information, or meat information related to a fertilized egg as the progress information.
  Fertilized egg quality evaluation system.   The fertilized egg quality evaluation system according to claim 1,
  The output unit outputs the evaluation support information updated at a predetermined time interval to the embryo cultivator or the producer.
  Fertilized egg quality evaluation system. The fertilized egg quality evaluation system according to claim 1,
  The acquisition unit acquires in real time a time-lapse image of a fertilized egg associated with at least the identification information.
  Fertilized egg quality evaluation system. A fertilized egg quality evaluation system including an information processing device for performing quality evaluation of a fertilized egg by cloud computing,
  The information processing apparatus includes:
    An acquisition unit that acquires identification information and time-lapse images of fertilized eggs from a producer through a network;
    A time-lapse image of each fertilized egg linked to the identification information is applied to a learned model generated using learning data including a time-lapse image of a fertilized egg and movement information based on the time-lapse image of the fertilized egg. An analysis unit that generates fertilized egg analysis information for each fertilized egg,
    An output unit that outputs evaluation support information including fertilized egg analysis information for each fertilized egg associated with the identification information and the identification information to the embryo cultivator or producer via the network;
  Have
  The evaluation support information is displayed on a web browser displayed on a terminal capable of receiving fertilized egg evaluation information for each fertilized egg input by the embryo cultivator or the producer based on the evaluation support information. Information
  Fertilized egg quality evaluation system. An acquisition unit that acquires identification information and time-lapse images of fertilized eggs from a producer through a network;
  A time-lapse image of each fertilized egg linked to the identification information is applied to a learned model generated using learning data including a time-lapse image of a fertilized egg and movement information based on the time-lapse image of the fertilized egg. An analysis unit that generates fertilized egg analysis information for each fertilized egg,
  An output unit that outputs evaluation support information including fertilized egg analysis information for each fertilized egg associated with the identification information and the identification information to the embryo cultivator or producer via the network;
  Comprising
  The evaluation support information is information displayed on a web browser capable of receiving fertilized egg evaluation information for each fertilized egg input by the embryo cultivator or the producer based on the evaluation support information.
  Information processing device. Obtaining identification information and time-lapse images of fertilized eggs from producers via a network;
  A time-lapse image of each fertilized egg linked to the identification information is applied to a learned model generated using learning data including a time-lapse image of a fertilized egg and movement information based on the time-lapse image of the fertilized egg. A step of generating fertilized egg analysis information for each fertilized egg,
  Outputting the evaluation support information including the identification information and fertilized egg analysis information for each fertilized egg linked to the identification information to the embryo cultivator or producer via the network;
  Comprising
  The evaluation support information is information displayed on a web browser capable of receiving fertilized egg evaluation information for each fertilized egg input by the embryo cultivator or the producer based on the evaluation support information.
  Information processing method. Obtaining identification information and time-lapse images of fertilized eggs from producers via a network;
  A time-lapse image for each fertilized egg associated with the identification information is applied to a learned model generated using learning data including a time-lapse image of a fertilized egg and movement information based on the time-lapse image of the fertilized egg. Generating fertilized egg analysis information for each fertilized egg,
  Outputting the evaluation support information including the identification information and fertilized egg analysis information for each fertilized egg linked to the identification information to the embryo cultivator or producer via the network;
  To the information processing device,
  The evaluation support information is information displayed on a web browser capable of receiving fertilized egg evaluation information for each fertilized egg input by the embryo cultivator or the producer based on the evaluation support information.
  program.

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