JP6372804B2 - Biological information measuring device and program thereof - Google Patents

Description

  The present invention relates to a portable biological information measuring device and a program thereof.

  With the recent development of wearable devices, biological information measuring devices capable of measuring biological information in daily life have become widespread. The biological information measuring apparatus of Patent Document 1 as an example thereof includes a three-axis acceleration sensor that outputs a signal according to body movement, a heart rate sensor that outputs a signal according to a heartbeat, and a signal output from each sensor. A calculation unit is provided. The calculation unit calculates calories burned based on the output signal of the 3-axis acceleration sensor, the body weight of the living body, the basal metabolic coefficient of the living body, and the usage time of the living body information measuring device, and the output signal of the heart rate sensor is fast Fourier transformed. The index value of the autonomic nerve function is calculated by conversion. Next, the calculation unit determines the characteristics of the living body based on the determination table for classifying the characteristics of the living body and the combination of the calculated calorie consumption and the index value.

JP 2013-78543 A JP 2004-267409 A

  As described above, the biological information measuring device of Patent Document 1 is a measuring device that comprehensively evaluates characteristics of a living body based on calorie consumption and an index value. For this reason, the change of the autonomic nerve function in daily life cannot be measured.

  On the other hand, as an apparatus capable of measuring an autonomic nerve function, for example, Patent Document 2 discloses a biological information measuring apparatus that measures an autonomic nerve function of a living body immersed in a bathtub. By diverting the function of this biological information measuring device to a portable measuring device, it is considered that a biological information measuring device capable of measuring an autonomic nerve function in daily life is realized.

  However, the autonomic nervous function changes under the influence of the activity state of the living body. The activity state of the living body is, for example, the posture of the living body. However, the biological information measuring device of Patent Document 2 does not particularly take into consideration the influence of the biological activity state on the autonomic nervous function. For this reason, when a portable biological information measuring device is configured based on the biological information measuring device of Patent Document 2, for example, it is autonomous due to the influence of the activity state of the living body even though the autonomic nerve function is reduced. There is a risk that the nerve function is determined to be normal.

  An object of the present invention is to provide a biological information measuring apparatus and a program therefor, in which an accurate measurement result relating to the activity state of the autonomic nerve function is easily obtained.

  One form of the biological information measuring device according to the present invention is a portable biological information measuring device that measures an autonomic nervous function, and a biological state that measures an activity state of a living body based on exercise information that is information related to the movement of the living body. A neuron state measurement unit that measures an activity state of an autonomic nervous function based on a measurement unit, pulse wave information that is information related to a pulse wave, and activity state measurement information that is an activity state of a living body measured by the body state measurement unit With.

  One form of the program of the biological information measuring device according to the present invention is a program for operating the biological information measuring device, the activity state measuring information measured by the biological state measuring unit, and the nerve calculated by the calculating unit. A step of causing the biological information measuring device to acquire the index value; and a step of causing the nerve state measurement unit to measure the activity state of the autonomic nerve function based on the activity state measurement information and the nerve index value.

  According to the biological information measuring apparatus and the program thereof, it is easy to obtain an accurate measurement result regarding the activity state of the autonomic nerve function.

FIG. 2 is a front view of the biological information measuring apparatus according to the first embodiment. FIG. 2 is a rear view of the biological information measuring device of FIG. 1. FIG. 2 is a front view showing an example of use of the biological information measuring device of FIG. 1. FIG. 2 is a block diagram showing a control configuration of the biological information measuring apparatus of FIG. 1. Is an example of the relationship between the activity state of the living body and the autonomic nerve index. Is an example of a measurement result regarding the activity state of the autonomic nervous function. FIG. 3 is a flowchart showing an operation of the biological information measuring apparatus of FIG. 1. FIG. 8 is a flowchart showing details of step S5 in FIG. These are side views which show an example of use of the biological information measuring device of Embodiment 2. FIG. 10 is a rear view of the biological information measuring device of FIG. 9. FIG. 10 is a block diagram showing a control configuration of the biological information measuring apparatus of FIG. 9. FIG. 10 is a flowchart showing an operation of the biological information measuring apparatus of FIG. 9. FIG. 13 is a flowchart showing details of step S105 in FIG. FIG. 10 is a graph of autonomic nerve activity displayed on the display unit of FIG. 9. FIG. 10 is a graph of autonomic nerve balance displayed on the display unit of FIG. 9.

(An example of a form that the biological information measuring device can take)
[1] One form of the biological information measuring apparatus according to the present invention is a portable biological information measuring apparatus that measures an autonomic nerve function, and measures the activity state of a living body based on exercise information that is information related to the movement of the living body. To measure the activity state of the autonomic nervous function based on the living body state measurement unit, the pulse wave information that is information on the pulse wave, and the activity state measurement information that is the activity state of the living body measured by the biological state measurement unit A state measuring unit.

  The activity state of the autonomic nervous function is mainly reflected in the pulse wave. For this reason, when the pulse wave is not substantially affected by disturbance, the activity state of the autonomic nerve function measured based on the pulse wave information is considered to have a high correlation with the actual activity state of the autonomic nerve function. . On the other hand, when the activity state of the living body has a large influence on the pulse wave, the activity state of the autonomic nerve function measured based on the pulse wave information may be different from the actual activity state of the autonomic nerve function .

  Based on this point, the biological information measuring device is basically based on the pulse wave information reflecting the activity state of the autonomic nervous function and the activity state of the living body that may affect the pulse wave information. Measure the activity of autonomic nervous function. For this reason, the activity state of the autonomic nerve function in which the influence of the activity state of the living body on the activity state of the autonomic nerve function is removed or reduced is measured. For this reason, it is easy to obtain an accurate measurement result regarding the activity state of the autonomic nerve function in daily life, for example, by the biological information measuring device.

  [2] According to an example of the biological information measurement device, the biological information measurement device further includes a calculation unit that calculates a nerve index value, which is an index indicating the activity state of the autonomic nerve function, based on the pulse wave information. The activity state of the autonomic nerve function is measured based on the nerve index value calculated by the unit and the activity state measurement information.

  According to an example of the method for measuring the activity state of the autonomic nerve function, the nerve index value is compared with the determination value, and the activity state of the autonomic nerve function corresponds to any of a plurality of categories determined in advance according to the result It is determined whether to do it. However, when the activity state of the living body has a great influence on the pulse wave information, the nerve index value may be different from the actual activity state of the autonomic nerve function. For this reason, even if the nerve index value is used for measurement, it is difficult to accurately measure the activity state of the autonomic nerve function.

  Based on this point, the biological information measuring apparatus measures the activity state of the autonomic nerve function based on the nerve index value and the activity state measurement information. For this reason, even if the activity state of the living body has a large influence on the pulse wave information, the influence of the activity state of the living body on the activity state of the autonomic nerve function is removed or reduced. The state is measured.

[3] According to an example of the biological information measuring apparatus, the information processing apparatus further includes a storage unit that stores the activity state measurement information and the nerve index value in association with each other.
When the activity state measurement information and the nerve index value stored in association with each other are output to an external device, for example, the relationship between the activity state measurement information and the nerve index value can be analyzed in detail by the analysis device. And the result of an analysis is reflected in a nerve state measurement part, for example, and it becomes easy to obtain a more exact measurement result about the activity state of an autonomic nerve function.

[4] According to an example of the biological information measuring device, the nerve state measuring unit measures the activity state of the autonomic nerve function for each of the activity states of a plurality of living bodies classified into the same type.
According to this biological information measuring apparatus, it is possible to confirm changes in the autonomic nervous function in the activity state of the same type of living body. In general, it is considered that the activity states of the autonomic nerve function are approximately similar if the types of the activity states of the living body are the same. For this reason, when the significant difference can be confirmed in the activity state of the autonomic nerve function in the activity state of the same kind of living body, for example, the living body may not be able to maintain a healthy state. For this reason, the said biological information measuring device can apply the comparison result of the activity state of an autonomic-nerve function to various determination regarding a biological body.

[5] According to the example of the biological information measuring device, the nerve state measuring unit measures the activity state of the autonomic nerve function for each of the activity states of a plurality of living bodies classified into different types.
According to this biological information measuring apparatus, it is possible to confirm changes in the autonomic nervous function in the activity state of the same type of living body. In general, when the types of biological activity states are different, the autonomic nervous function in each activity state is considered to indicate a different activity state. For this reason, the comparison result of the activity state of the autonomic nerve function in the activity state of a different kind of living body may reflect the relative relationship of the reaction degree of the autonomic nerve function to the activity state of each living body. For this reason, the said biological information measuring device can apply the comparison result to various determination regarding a biological body.

[6] According to an example of the biological information measuring apparatus, the nerve state measuring unit measures the activity state of the autonomic nerve function when the activity state of the living body measured by the biological state measuring unit is in a stable period.
When the activity state of the living body is in a stable period, the influence of the activity state of the living body on the pulse wave is small, or the activity state of the living body does not substantially affect the pulse wave. For this reason, according to the said biological information measuring device, the more exact measurement result regarding the activity state of an autonomic nerve function is easy to be obtained.

[7] According to the example of the biological information measuring device, the nerve state measuring unit measures the activity state of the autonomic nerve function when the activity state of the living body measured by the biological state measuring unit is in a transitional period.
When the activity state of the living body is in a transition period, the influence of the activity state of the living body on the pulse wave is large. Therefore, the biological information measuring apparatus measures the influence of changes in the activity state of the living body on the activity state of the autonomic nerve function, and uses the measurement results for various determinations regarding the response speed of the autonomic nerve function to the activity state of the living body. Can be applied.

[8] According to an example of the biological information measuring device, the nerve state measuring unit measures the activity state of the autonomic nerve function when the activity state of the living body measured by the biological state measuring unit is an awake state.
According to this biological information measuring apparatus, it is possible to measure a change in the activity state of the autonomic nervous function accompanying a change in the activity state of the living body in the awake state. For this reason, the said biological information measuring device can apply the change of the activity state of the autonomic nerve function in daily life to various determination regarding a biological body, for example.

  [9] According to an example of the biological information measuring device, the biological state measurement unit measures the biological activity state based on biological state information including information related to at least one of the posture of the biological body and the amount of activity of the biological body.

  According to this biological information measuring apparatus, the activity state of the autonomic nerve function can be measured for each activity state of the living body measured according to at least one of the posture of the living body and the amount of activity of the living body. For this reason, the said biological information measuring device can apply a measurement result to various determination regarding a biological body.

  [10] According to an example of the biological information measuring device, the nerve state measurement unit measures the activity state of the autonomic nerve function when the biological activity state measured by the biological state measurement unit is a sleep state.

  According to this biological information measuring apparatus, it is possible to measure a change in the activity state of the autonomic nervous function accompanying a change in the activity state of the living body in the sleep state. For this reason, the said biological information measuring device can apply the change of the active state of the autonomic-nerve function in a sleep state to various determinations regarding a living body, for example.

[11] According to an example of the biological information measurement device, the biological state measurement unit divides the sleep state into a plurality of sleep stages.
According to this biological information measuring apparatus, the activity state of the autonomic nerve function can be measured for each sleep stage. For this reason, the said biological information measuring device can apply a measurement result to various determination regarding a biological body.

  [12] According to an example of the biological information measurement device, the biological state measurement unit includes: a first determination unit that determines whether or not the biological activity state is a sleep state using a first determination method; When the determination part of 1 determines that the activity state of the living body is the sleeping state, it is determined by the second determination method whether the activity state of the living body is the sleeping state, and a positive result is obtained. A second determination unit that determines that the biological activity state is a sleep state is provided.

  According to this biological information measuring apparatus, it is determined through two stages that the biological activity state is a sleeping state. For this reason, it is easy to obtain a more accurate measurement result regarding the activity state of the autonomic nerve function in the sleep state.

  [13] A program for operating the biological information measurement device, which causes the biological information measurement device to acquire activity state measurement information measured by the biological state measurement unit and a nerve index value calculated by the calculation unit And a step of causing the nerve state measurement unit to measure the activity state of the autonomic nerve function based on the activity state measurement information and the nerve index value.

[14] According to an example of the program of the biological information measuring device, the method further includes the step of causing the calculation unit to calculate a nerve index value based on the pulse wave information.
By storing the program [13] or [14] in a portable biological information measuring device, the biological information measuring device having the same or similar configuration as the biological information measuring device of [1] or [2] Is obtained. For this reason, the effect similar to or similar to the effect obtained by the biological information measuring device can be obtained.

(Embodiment 1)
The configuration of the biological information measuring apparatus 1 will be described.
As shown in FIG. 1, the biological information measuring apparatus 1 includes a main body 10 that stores components for measuring biological information, and a pair of mounting portions 13 that are attached to both sides of the main body 10. An example of the mounting portion 13 is a belt. A display unit 11 that displays biological information and the like is provided on the front surface 10 </ b> A of the main body 10. An example of the display unit 11 is a liquid crystal display. An input unit 12 serving as an operation button is provided on the side surface 10 </ b> C of the main body 10. A triaxial acceleration sensor 20 is provided inside the main body 10.

  As shown in FIG. 2, the back surface 10 </ b> B of the main body 10 is provided with a light emitting unit 22 and a light receiving unit 23 of a pulse wave detecting unit 21 that measures a pulse wave of a living body. An example of the light emitting unit 22 is a green light emitting diode. An example of the light receiving unit 23 is a photodiode.

As shown in FIG. 3, the biological information measuring apparatus 1 is attached to the wrist of the living body by the attaching unit 13. The light emitting unit 22 and the light receiving unit 23 (see FIG. 2) face the wrist and measure the pulse wave of the living body.
With reference to FIG. 4, the control structure of the biological information measuring device 1 will be described. The biological information measuring apparatus 1 performs a measurement of an autonomic nerve function, a three-axis acceleration sensor 20 that measures movement information that is information related to movement of a living body, a pulse wave detection unit 21 that detects pulse wave information that is information related to a pulse wave, and the like. A biological information measuring unit 30 and a display unit 11 are provided. The biological information measurement unit 30 measures a biological state measurement unit 32 that measures the state of the living body, a calculation unit 33 that calculates the autonomic nerve balance and the autonomic nerve activity, a storage unit 34 that stores the calculation results, and an autonomic nerve function. A nerve state measuring unit 36 is provided.

  The triaxial acceleration sensor 20 measures accelerations in three directions on the XYZ axes of the main body 10 which is an example of biological movement information. The light emitting unit 22 irradiates the wrist with light. The light receiving unit 23 receives light reflected by the wrist, and generates a light reception signal according to the received light amount. The pulse wave detection unit 21 detects a pulse wave of a living body based on the light reception signal.

  The biological state measurement unit 32 calculates a combined acceleration from the motion information of the measurement result of the triaxial acceleration sensor 20. Next, the living body state measuring unit 32 compares the synthesized acceleration with the activity threshold value, and thereby the activity state measurement information that is the living body's activity state is a state of being awake and a sleeping state that is a sleeping state. Classify as awake. The activity threshold is a value for discriminating between a sleep state and an awake state, and is set in advance by a test or the like. When the biological state measurement unit 32 determines that the state is an arousal state, the biological state measurement unit 32 further determines the activity state measurement information as a resting state, a walking state, or a running state.

The computing unit 33 computes entropy E, which is the degree of autonomic nerve activity, and tone T, which is the autonomic nerve balance, from the pulse wave detected by the pulse wave detecting unit 21. First, a heartbeat interval PP, which is one course of heart contraction and relaxation, is calculated. The heartbeat interval PP is the period of the pulse wave, and is the time between the maximum value of the received light signal and the maximum value of the next received light signal. Next, a PI (Percentage Index) value indicating the change in the heartbeat interval PP as a percentage is calculated by the following equation [1].

Here, PP _i indicates the i-th measured heartbeat interval PP.
And the calculating part 33 calculates entropy E by [2] Formula which is a formula of Shannon's average information amount.

Here, p (j) indicates the probability that the PI value obtained by the equation [1] is divided into N sections and a PI value is generated for the jth section.
Furthermore, the number of measurements of the heart rate interval PP is M, and the calculation unit 33 calculates the tone T for each biological activity state according to the following equation [3].

  The storage unit 34 stores the activity state measurement information determined by the biological state measurement unit 32, the nerve index value calculated by the calculation unit 33, the pulse wave information measured by the pulse wave detection unit 21, and the measurement time in association with each other. Examples of neural index values are tone T and entropy E. An example of the storage unit 34 is a RAM (Random Access Memory). The storage unit 34 performs a storage operation at a predetermined sampling interval. For example, if the sampling interval is 1 hour, the data is stored 24 times a day. Further, the storage unit 34 stores a threshold value used for state determination and a threshold value used for autonomic nervous function determination.

  The nerve state measurement unit 36 measures the autonomic nerve function using the activity state measurement information and the nerve index value read from the storage unit 34. As an example, the nerve state measuring unit 36 measures the autonomic nerve activity level and the autonomic nerve balance as follows. The entropy E is measured as the autonomic nerve activity level, and the negative value of the tone T is measured as the autonomic nerve balance. As an example of the threshold value, an average value of a living body of the same age as a living body to be determined or a past measurement value is used.

  The display unit 11 displays the determination result of the nerve state measurement unit 36. A display example is shown in FIG. T1, T2, T3, and T4 are the values of the tone T for each state of the living body, and E1, E2, E3, and E4 are the values of the entropy E for each state of the living body, for example, an average value or a maximum value. .

  Moreover, as FIG. 6 shows, the display part 11 displays the determination result table | surface of an autonomic-nerve function. The activity state of the autonomic nerve function is represented by the autonomic nerve activity level and the autonomic nerve balance. In one example, the determination result is classified as normal, decreased, or enhanced. The threshold value for classification is determined in advance by experiments or the like.

  With reference to FIG. 7, the operation of biological information measuring apparatus 1 of the first embodiment will be described. First, in step S1, the pulse wave detection unit 21 measures a pulse wave of a living body and creates pulse wave information that is information on the pulse wave of the living body. In step S2, the calculation unit 33 calculates a nerve index value from the pulse wave information.

  In step S <b> 3, the triaxial acceleration sensor 20 measures accelerations in three directions on the XYZ axes of the main body 10, which is an example of biological movement information. In step S4, the biological state measurement unit 32 calculates a combined acceleration from the motion information of the measurement result in step S3. In step S <b> 5, the living body state measuring unit 32 creates activity state measurement information that is a living body state by comparing the resultant acceleration and the activity threshold value.

  The operation of step S5 will be described in detail with reference to FIG. In step S5A, the biological state measurement unit 32 calculates the integrated value of the resultant acceleration calculated in step S4. And the biological state measurement part 32 compares with the activity threshold which shows the standard of the integral value of the synthetic acceleration at the time of awakening, and the active state measurement information is in the sleeping state which is a sleeping state or the awakened state. It is determined that there is a certain arousal state.

  When the activity state measurement information indicates the awake state, the calculation unit 33 calculates the activity amount of the living body in step S5B. METs (METabolic equivalents) are used as an example of biological activity. The standard deviation value of the composite acceleration is converted into the METs value. As the coefficient to be converted, a value determined in advance by experiments or the like is used. When the METs value is smaller than the rest threshold, the living body state measuring unit 32 determines that the living body activity state is the resting state in step S5C.

  When the METs value is not less than the rest threshold and not more than the walking threshold, the living body state measuring unit 32 determines in step S5D that the amount of activity of the living body is the walking state. If the METs value is greater than the walking threshold, the biological state measurement unit 32 determines in step S5D that the amount of activity of the biological body is in the running state. The rest threshold and the walking threshold are determined in advance by experiments or the like.

When the activity state measurement information indicates the sleep state, in step S5E, the calculation unit 33 calculates a count number that is a value obtained by integrating the number of times that exceeds the threshold value of the combined acceleration for one minute. In step S5F, the biological state measurement unit 32 determines arousal. As an example of the determination method, the following equation [4], which is a Cole equation, is used.

  However, α0 is the count number at the time of determination, and αn1, αn2, αn3, αn4, α1, and α2 are 4 minutes before, 3 minutes before, 2 minutes before, 1 minute before, 1 minute after the determination, respectively. And the count after 2 minutes. Wn4, Wn3, Wn2, Wn1, W0, W1, and W2 are constants. In step S5F, the biological state measurement unit 32 determines that the biological activity state is an awake state when the determination value S is 1 or more, and when the determination value S is smaller than the determination value S, the biological activity state is the sleep state. Judge that there is.

  With reference to FIG. 7, the operation after step S5 will be described. In step S6, the storage unit 34 stores the nerve index value measured in step S2 and the activity state measurement information determined in step S5 in association with each other.

  In step S7, the calculation unit 33 determines the measurement time. That is, step S1 to step S6 are repeated until the measurement time exceeds a preset set time. When the measurement time exceeds the set time, the process proceeds to step S8.

  In step S8, the nerve state measuring unit 36 measures the activity state of the autonomic nerve function based on the activity state measurement information and the nerve index value. In step S8A, which is a part of step S8, the nerve state measurement unit 36 compares the nerve index value with a decrease threshold L that is a threshold for determining that the autonomic nerve function is decreasing, and the autonomic nerve Determine function. The decrease threshold L is set separately for each state of the living body and is obtained in advance by a test or the like. When it is determined that the autonomic nerve function is reduced, in step S9, the display unit 11 displays the decrease in the autonomic nerve function. If it is determined that the autonomic nerve function is not lowered, the process proceeds to step S8B which is a part of step S8.

  In step S8B, the nerve state measurement unit 36 compares the nerve index value with the enhancement threshold H that is a threshold for determining that the autonomous nerve function is enhanced, and determines the autonomous nerve function. The enhancement threshold value H is set separately for each state of the living body and is obtained in advance by a test or the like. When it is determined that the autonomic nerve function is enhanced, in step S9, the display unit 11 displays the enhancement of the autonomic nerve function. If it is determined that the autonomic nerve function is not enhanced, the display unit 11 displays normal autonomic function in step S9.

According to the biological information measuring apparatus 1 of the first embodiment, the following effects can be obtained.
(1) The biological information measuring unit 30 determines whether the autonomic nervous function is based on the pulse wave information that reflects the active state of the autonomic nerve function and the active state of the living body that may affect the pulse wave information. Measure activity status. For this reason, the activity state of the autonomic nerve function in which the influence of the activity state of the living body on the activity state of the autonomic nerve function is removed or reduced is measured. For this reason, it is easy to obtain an accurate measurement result regarding the activity state of the autonomic nerve function in daily life.

  (2) The biological information measuring unit 30 measures the activity state of the autonomic nerve function based on the nerve index value and the activity state measurement information. For this reason, even if the activity state of the living body has a large influence on the pulse wave information, the influence of the activity state of the living body on the activity state of the autonomic nerve function is removed or reduced. The state is measured.

  (3) The storage unit 34 stores the activity state measurement information and the nerve index value in association with each other. For this reason, when the activity state measurement information and the nerve index value are output to an external device, for example, the relationship between the activity state measurement information and the nerve index value can be analyzed in detail by the analysis device. And the result of an analysis is reflected in a nerve state measurement part, for example, and it becomes easy to obtain a more exact measurement result about the activity state of an autonomic nerve function.

  (4) The nerve state measurement unit 36 measures the activity state of the autonomic nerve function for each of the activity states of a plurality of living bodies classified into the same type. For this reason, a significant difference can be confirmed in the activity state of the autonomic nerve function in the activity state of the same kind of living body, and the comparison result of the activity state of the autonomic nerve function can be applied to various determinations related to the living body.

  (5) The nerve state measurement unit 36 measures the activity state of the autonomic nerve function when the activity state of the living body measured by the living body state measurement unit 32 is the awake state. For this reason, the change of the active state of the autonomic nervous function accompanying the change of the active state of the living body in the awake state can be measured, and the change of the active state of the autonomic nervous function in daily life can be applied to various determinations related to the living body.

  (6) The activity state of the living body is classified according to the amount of activity of the living body. For this reason, the activity state of an autonomic nerve function can be measured for every activity state of the living body classified according to the amount of activity. Therefore, the measurement result can be applied to various determinations related to the living body.

  (7) The nerve state measurement unit 36 measures the activity state of the autonomic nerve function when the activity state of the living body measured by the living body state measurement unit 32 is a sleep state. For this reason, the change of the activity state of the autonomic nerve function accompanying the change of the activity state of the living body in the sleep state can be measured, and the change of the activity state of the autonomic nerve function in the sleep state can be applied to various determinations related to the living body.

  (8) The biological state measurement unit 32 determines that the biological activity state is a sleeping state through two stages. For this reason, it is easy to obtain a more accurate measurement result regarding the activity state of the autonomic nerve function in the sleep state.

(Embodiment 2)
With reference to FIG. 9, the structure of the biological information measuring device 1 of Embodiment 2 is demonstrated. The biological information measuring apparatus 1 according to the second embodiment is different from the first embodiment in that it is configured to communicate with a portable information terminal 40 as an example of an external device and in that it considers brain waves and atmospheric pressure. .

  The biological information measuring device 1 includes a main body 10 and a portable information terminal 40 for displaying biological information. The portable information terminal 40 is a smartphone as an example. The portable information terminal 40 and the main body 10 communicate wirelessly. An example of the communication method is Bluetooth (registered trademark). The portable information terminal 40 acquires information transmitted from the main body 10 and displays the determination result of the autonomic nervous function on the display unit 11. Examples of the display are FIGS. 5, 6, 14, and 15. FIG. The main body 10 is attached to the head of a living body.

  With reference to FIG. 10, the structure of the main body 10 of Embodiment 2 is demonstrated. On the back surface 10 </ b> B of the main body 10, a light emitting unit 22 and a light receiving unit 23 of the pulse wave detecting unit 21, an electroencephalogram sensor 24 that measures a brain wave of a living body, and an atmospheric pressure sensor 25 that measures the posture of the living body. When worn on the head of the living body, the electroencephalogram sensor 24 contacts the forehead portion of the living body.

With reference to FIG. 11, a control configuration of biological information measuring apparatus 1 according to the second embodiment will be described.
The main body 10 includes a three-axis acceleration sensor 20, a pulse wave detection unit 21, an electroencephalogram sensor 24, an atmospheric pressure sensor 25, and a biological information measurement unit that is a part of the biological information measurement unit 30 that spans the main body 10 and the portable information terminal 40. A main body 30A is provided. The portable information terminal 40 includes a biological information measuring unit terminal 30 </ b> B that is a part of the biological information measuring unit 30 and the display unit 11.

  The triaxial acceleration sensor 20 measures movement information of a living body. The pulse wave detector 21 detects a pulse wave of a living body. The electroencephalogram sensor 24 includes electrodes, and measures a potential difference at least at two or more measurement locations on the head. A change in a weak electrical signal associated with brain activity is detected as a weak potential difference on the surface of the head. The brain's active part is identified by the part to be measured, and the electroencephalogram waveform is acquired by amplifying a weak current. The atmospheric pressure sensor 25 detects a relative or absolute altitude by a change in atmospheric pressure.

  The biological information measurement unit 30 includes a biological state measurement unit 32, a calculation unit 33, a storage unit 34, a main body communication unit 37 for communicating with the portable information terminal 40, a terminal communication unit 38 for communication with the main body 10, and a storage. Unit 34 and nerve state measuring unit 36.

  The biological state measurement unit 32 calculates a combined acceleration from the acceleration of the measurement result of the triaxial acceleration sensor 20. The posture of the living body is determined based on a change in altitude detected by the atmospheric pressure sensor 25. Further, the activity state measurement information is determined based on the combined acceleration, the electroencephalogram measured by the electroencephalogram sensor 24, and the posture of the living body. In addition, the biological state measurement unit 32 uses the first determination unit 32A that determines whether or not the sleep state is determined by the first determination method that determines the sleep state, and the sleep state by the second determination method that determines the sleep state. 2nd determination part 32B which determines whether it is.

  The calculator 33 calculates entropy E and tone T from the pulse wave information detected by the pulse wave detector 21. The storage unit 34 stores the activity state measurement information determined by the biological state measurement unit 32, the tone T and entropy E calculated by the calculation unit 33, the pulse wave information measured by the pulse wave detection unit 21, and the measurement time. The main body communication unit 37 transmits the information stored in the storage unit 34 to the portable information terminal 40.

  The portable information terminal 40 includes a terminal communication unit 38, a storage unit 34, a nerve state measurement unit 36, and a display unit 11. The terminal communication unit 38 acquires the information transmitted by the main body communication unit 37 and sends it to the storage unit 34. The storage unit 34 stores the received information. The nerve state measurement unit 36 determines the autonomic nerve function using the activity state measurement information read from the storage unit 34, the tone T, and the entropy E. The determination result of the nerve state measuring unit 36 is stored in the storage unit 34. Further, the display unit 11 displays the determination result of the nerve state measuring unit 36.

  With reference to FIG. 12, operation | movement of the biometric information measuring device 1 of Embodiment 2 is demonstrated. In step S101, the pulse wave detector 21 measures the pulse wave of the living body and creates pulse wave information. In step S102, the calculation unit 33 calculates a nerve index value from the pulse wave information. Examples of neural index values are tone T and entropy E. In step S103, the triaxial acceleration sensor 20 measures biological motion information. In step S104, the biological state measurement unit 32 calculates a combined acceleration from the acceleration of the measurement result in step S103. In step S105, activity state measurement information that is the state of the living body is created based on the acceleration in the three directions of the XYZ axes and the combined acceleration.

  The operation of step S105 will be described in detail with reference to FIG. In step S105A, the living body state measurement unit 32 calculates the direction of the gravity vector from the accelerations in the three directions of the XYZ axes, and determines the head direction of the living body. Examples of the living body head direction are supine left, supine, supine right, right facing, prone left, prone, prone right, left facing, and standing.

  In step S105B, the atmospheric pressure sensor 25 measures the atmospheric pressure and estimates the height of the head of the living body. In step S105C, the living body state measuring unit 32 determines the posture of the living body from the head direction of the living body and the measured atmospheric pressure. Examples of the posture of the living body are a supine position, a sitting position, and a standing position.

  In step S <b> 105 </ b> D, the biological state measurement unit 32 determines whether it is a sleep state by the first determination method. An example of the first determination method is determination of whether or not the posture of the living body determined in step S105C is supine and resting for a certain period of time. When it continues for a fixed time, a 1st determination part determines activity state measurement information to be a sleep state. When it is determined in step S105D that the activity state measurement information is the sleep state, in step S105E, a count number that is the number of times that the number of times exceeding the threshold value of the combined acceleration is accumulated for one minute is calculated. In step S105F, the awakening is determined by the second determination method using the count obtained in step S105E. An example of the second determination method is the Cole formula. When the determination value S of the Cole expression is 1 or more, the second determination unit determines that the living body is in the awake state, and proceeds to step S106. When the determination value S is smaller than 1, the second determination unit determines that the living body is in the sleeping state, and the electroencephalogram sensor 24 measures the electroencephalogram of the living body in step S105G. In step S105H, the biological state measuring unit 32 performs frequency analysis on the measured brain waves of the biological body.

  In step S105I, the biological state measurement unit 32 determines a sleep stage representing a sleep stage based on the analysis result of step S105H, and the process proceeds to step S106. Examples of sleep stages are the REM sleep state, stage 1, stage 2, stage 3, and stage 4.

  If it is determined in step S105D that the activity state measurement information is not a sleep state, in step S105J, the calculation unit 33 calculates a METs value that is an example of a biological activity amount. If the METs value is smaller than the rest threshold, the biological state measurement unit 32 determines that the biological activity state is the rest state, and proceeds to step S106. If the METs value is greater than or equal to the rest threshold, the biological state measurement unit 32 determines that the amount of activity of the biological body is not in the rest state, and proceeds to step S105L. If the METs value is greater than or equal to the rest threshold and less than or equal to the walking threshold in step S105L, the biological state measurement unit 32 determines that the amount of biological activity is the walking state, and proceeds to step S106. If the METs value is greater than the walking threshold, the biological state measurement unit 32 determines that the amount of biological activity is the running state, and proceeds to step S106.

  With reference to FIG. 12, the operation after step S105 will be described. In step S106, the storage unit 34 stores the nerve index value measured in step S102 and the activity state measurement information determined in step S105 in association with each other.

  In step S107, the calculation unit 33 determines the measurement time. That is, steps S101 to S106 are repeated until the measurement time exceeds a preset set time. When the measurement time exceeds the set time, the process proceeds to step S108.

  In step S <b> 108, the main body communication unit 37 (see FIG. 11) transmits to the portable information terminal 40 measurement information including nerve index values, activity state measurement information, pulse wave information, and measurement time. In step S109, the terminal communication part 38 (refer FIG. 11) acquires measurement information, and the memory | storage part 34 memorize | stores it.

  In step S110, the nerve state measurement unit 36 measures the activity state of the autonomic nerve function based on the activity state measurement information and the nerve index value. In step S110A, which is a part of step S110, the nerve state measurement unit 36 compares the nerve index value with the decrease threshold L to determine the autonomic nerve function. If it is determined that the autonomic nerve function is degraded, the display unit 11 displays that the autonomic nerve function is degraded in step S111. If it is determined that the autonomic nerve function has not deteriorated, the process proceeds to step S110B which is a part of step S110.

  In step S110B, the nerve state measuring unit 36 compares the tone T and entropy E with the enhancement threshold H to determine the autonomic nerve function. If it is determined that the autonomic nervous function is enhanced, the display unit 11 displays that the autonomic nervous function is enhanced in step S111. If it is determined that the autonomic nerve function is normal, the display unit 11 displays that the autonomic nerve function is normal in step S111.

  Here, in the determination of the autonomic nerve function in the sleep state, the autonomic nerve activity level and the sleep stage are used. With reference to FIG. 14, an example of determination using the autonomic nerve activity level will be described. The autonomic nerve activity is compared for each sleep stage, and the autonomic nerve function is determined. In a normal state, the level of autonomic nerve activity increases as the sleep stage becomes deeper, and is maximized at stage 4. The normal value is set in advance by experiments or the like, and a normal value based on the same age of the living body, the same sex, and the past memory of the living body may be used. Further, instead of entropy E as the degree of autonomic nerve activity, for example, TP (Total Power) obtained by frequency analysis of heart rate variability may be used. TP is, for example, an integral value of a power spectrum.

  The autonomic nerve balance is used in the determination of the autonomic nerve function in the awake state. An example of determination using the autonomic nerve balance will be described with reference to FIG. The time at which the posture determined in step S105C (see FIG. 13) changes is defined as time t0. An example of the change is from sitting to standing. It is known that the sympathetic nerve of a living body's autonomic nerve is reflexively increased by posture change. The autonomic nerve balance at time t0 is St0, and the autonomic nerve balance at time t2 after the elapse of the stabilization time ts, which is a measure of the time required for the autonomic nerve to stabilize from time t0, is St2. Let the autonomic nerve balance at the time t1 before the stable time ts elapse from the time t0 be St1. The time t1 is a time when, for example, about 1 to 2 minutes have elapsed from the time t0. For example, by confirming the recovery of the autonomic nerve balance at time t1, the response of the autonomic nerve function to the posture change can be evaluated.

  The evaluation of the autonomic nerve balance at time t2 is an evaluation in a state in which a sufficient time has elapsed from the change in posture. A steady autonomic function by posture conversion can be determined by comparing the sitting and standing states in a stable state in which the fluctuation of the nerve index value is almost eliminated. Here, when the autonomic nerve balance is high, it is determined that the sympathetic nerve function is enhanced.

  As an example of the autonomic nervous function index evaluation, a comparison with past nerve index values is performed. For example, let St3 be the autonomic nerve balance at t3, which is the time when the posture changes at the time of the previous measurement at the time t0. The autonomic nerve balance at the time t5 after the stable time ts has elapsed from the time t3 is St5, and the autonomic nerve balance at the time t4 before the stable time ts has elapsed from the time t3 is St4. St2 / St0 and St5 / St0, which are ratios to the autonomic nerve balance at the previous measurement, are compared. Also, St1 / St0 is compared with St4 / St0. For example, if St2 / St0 and St1 / St0 are high, it is determined that the sympathetic nerve function is enhanced. As the autonomic nerve balance, for example, LF / HF obtained by frequency analysis of heart rate variability may be used. LF (Low Frequency) is, for example, a power spectrum having a waveform with a period of about 10 seconds. HF (High Frequency) is a power spectrum of a waveform with a period of 3 to 4 seconds, for example.

According to the biological information measuring apparatus 1 of the second embodiment, in addition to the effects obtained by the biological information measuring apparatus 1 of the first embodiment, the following effects are further obtained.
(9) The nerve state measurement unit 36 measures the activity state of the autonomic nerve function for each of the activity states of a plurality of living bodies classified into different types. For this reason, the relative relationship of the reaction degree of the autonomic nerve function with respect to the activity state of a different kind of biological body can be confirmed, and it can apply to various determinations regarding a biological body.

  (10) The nerve state measuring unit 36 measures the activity state of the autonomic nerve function when the activity state of the living body measured by the living body state measuring unit 32 is in a stable period. For this reason, the influence of the biological activity state on the pulse wave is small, or the biological activity state does not substantially affect the pulse wave. For this reason, it is easy to obtain a more accurate measurement result regarding the activity state of the autonomic nervous function.

  (11) The nerve state measuring unit 36 measures the activity state of the autonomic nerve function when the living state of the living body measured by the living body state measuring unit 32 is in a transition period. For this reason, the influence which the change of the activity state of a biological body has on the activity state of an autonomic nerve function is measured, and a measurement result can be applied to various determinations regarding the response speed of the autonomic nerve function to the activity state of the living body.

  (12) The biological state measurement unit 32 measures the biological activity state based on biological state information including information on at least one of the posture of the biological body and the amount of activity of the biological body. For this reason, the activity state of the autonomic nerve function can be measured for each activity state of the living body measured according to the posture of the living body, and the measurement result can be applied to various determinations related to the living body.

  (13) The biological state measurement unit 32 classifies the sleep state into a plurality of sleep stages. For this reason, the activity state of an autonomic nerve function can be measured for every sleep stage, and a measurement result can be applied to various determinations regarding a living body.

(Modification)
The description regarding each said embodiment is an illustration of the form which the biological information measuring device according to this invention can take, and it does not intend restrict | limiting the form. The biological information measuring device according to the present invention may take a form in which, in addition to the embodiments, for example, modifications of the above-described embodiments described below and at least two modifications not contradicting each other are combined.

The pulse wave detection unit 21 may perform electrocardiogram measurement using electrodes.
The triaxial acceleration sensor 20 may be an angular velocity sensor. A combined angular velocity obtained by combining the angular velocities of the respective axes output from the angular velocity sensor may be used in place of the combined acceleration obtained by combining the accelerations output from the respective axes by the triaxial acceleration sensor 20.

  The portable information terminal 40 may be a tablet information terminal or a notebook personal computer instead of the smartphone. The external device including the portable information terminal 40 is not limited to a portable type, and may be a desktop personal computer or other stationary information terminal.

  The storage unit 34 may be a magnetic disk, a flash memory, or an SSD (Solid State Drive) instead of the RAM. Data can be input or output by making the storage unit 34 detachable.

  The calculation unit 33 may calculate the number of steps, METs, calorie consumption, or PAL (Physical Activity Level) as the biological activity state. Moreover, you may use the frequency component by a frequency analysis.

-The calculating part 33 may replace with the method of calculating entropy E by Shannon's average information amount, and may use the method of calculating by Renyi entropy.
A sympathetic nerve index and a parasympathetic nerve index may be used as the nerve index value. This sympathetic nerve index can be calculated by LF / HF of the frequency analysis method.

The calculation unit 33 may perform frequency analysis instead of the entropy E calculation.
The main body 10 may not include the mounting portion 13. For example, the living body can carry the main body 10 by housing the main body 10 in the pocket of the living body. Further, the main body 10 can be mounted by fixing the main body 10 to the wrist by hand.

-The activity state of the living body in the awake state may be further divided according to the amount of activity.
-The activity state of the living body in the sleep state may be further divided according to the count number.
In step S5F, the AW2 equation, which is an equation for determining sleep, may be used instead of the Cole equation.

-By adjusting the threshold for determining the autonomic nervous function, the living body is not limited to a human but may be an animal.
If it is determined in step S105D that it is not sleep, the process may return to step S103 without proceeding to step S105J, and step S105D may be further repeated.

-The main body 10 of Embodiment 2 may be attached to a wrist and measure a pulse wave.
-The nerve state measurement part 36 of Embodiment 2 may be provided in the biological information measurement part main body 30A.
In the determination of the autonomic nerve in the sleep state according to the second embodiment, other autonomic nerve indexes such as autonomic nerve balance, sympathetic nerve activity, and parasympathetic nerve activity may be used.

In the determination of the autonomic nerve in the active state of the second embodiment, other autonomic nerve indices such as the degree of autonomic nerve activity, sympathetic nerve activity, and parasympathetic nerve activity may be used.
Steps S105A to S105C may be performed before the calculation of the combined acceleration in step S104.

  The biological information measuring device according to one embodiment of the present invention can determine the autonomic nervous function with high accuracy, and thus can be used for measuring autonomic function during sports and measuring a baby, an elderly person, or an animal. it can.

DESCRIPTION OF SYMBOLS 1: Biological information measuring device 21: Pulse wave detection part 32: Biological state measurement part 32A: 1st determination part 32B: 2nd determination part 33: Calculation part 34: Storage part 36: Neural state measurement part

Claims (12)

A portable biological information measuring device that measures autonomic nerve function,
A biological state measurement unit that measures the biological activity state based on movement information that is information related to the movement of the biological body;
A nerve state measuring unit that measures an activity state of an autonomic nerve function based on pulse wave information that is information related to a pulse wave and activity state measurement information that is an activity state of the living body measured by the living body state measuring unit; Prepared ,
The nerve state measuring unit is a biological information measuring device that measures an activity state of an autonomic nerve function for each of a plurality of activity states of the living body classified into the same type . A portable biological information measuring device that measures autonomic nerve function,
A biological state measurement unit that measures the biological activity state based on movement information that is information related to the movement of the biological body;
A nerve state measuring unit that measures an activity state of an autonomic nerve function based on pulse wave information that is information related to a pulse wave and activity state measurement information that is an activity state of the living body measured by the living body state measuring unit; Prepared ,
The biological information measuring device that measures an activity state of an autonomic nerve function for each of a plurality of activity states of the living body classified into different types . A portable biological information measuring device that measures autonomic nerve function,
A biological state measurement unit that measures the biological activity state based on movement information that is information related to the movement of the biological body;
A nerve state measuring unit that measures an activity state of an autonomic nerve function based on pulse wave information that is information related to a pulse wave and activity state measurement information that is an activity state of the living body measured by the living body state measuring unit; Prepared ,
The neural state measurement unit measures the activity state of the autonomic nerve function when the biological activity state measured by the biological state measurement unit is a sleep state,
The living body state measuring unit is a living body information measuring device that divides the sleeping state into a plurality of sleep stages . A portable biological information measuring device that measures autonomic nerve function,
A biological state measurement unit that measures the biological activity state based on movement information that is information related to the movement of the biological body;
A nerve state measuring unit that measures an activity state of an autonomic nerve function based on pulse wave information that is information related to a pulse wave and activity state measurement information that is an activity state of the living body measured by the living body state measuring unit; Prepared ,
The neural state measurement unit measures the activity state of the autonomic nerve function when the biological activity state measured by the biological state measurement unit is a sleep state,
The biological state measurement unit is configured to determine whether or not the biological activity state is a sleeping state by a first determination unit, and the first determination unit determines whether the biological activity state is a sleep state. When it is determined that the living state is a sleeping state, the second determining method determines whether the living state is a sleeping state, and when the positive result is obtained, the living state is the sleeping state. A biological information measuring device provided with the 2nd judgment part which determines that there exists . An arithmetic unit that calculates a nerve index value that is an index indicating an activity state of the autonomic nerve function based on the pulse wave information;
The nerve state measurement unit measures an activity state of an autonomic nerve function based on the nerve index value calculated by the operation unit and the activity state measurement information.
The biological information measuring device according to any one of claims 1 to 4 . A storage unit for storing the activity state measurement information and the nerve index value in association with each other;
The biological information measuring device according to claim 5 . The neural state measurement unit measures the activity state of the autonomic nerve function when the biological activity state measured by the biological state measurement unit is in a stable period.
The biological information measuring device according to any one of claims 1 to 6 . The neural state measurement unit measures the activity state of the autonomic nerve function when the biological activity state measured by the biological state measurement unit is in a transitional period.
The biological information measuring device according to any one of claims 1 to 7 . The nerve state measurement unit measures the activity state of the autonomic nerve function when the activity state of the living body measured by the body state measurement unit is an awake state.
The biological information measuring device according to any one of claims 1 to 8 . Measuring the activity status of the subject based on the biological condition measurement unit posture and activity level of at least one of information including raw material state information regarding the biological biological
The biological information measuring device according to claim 9 . A program for operating the biological information measuring device according to any one of claims 1 to 10 ,
A first step of causing the biological information measuring device to acquire the pulse wave information and the activity state measurement information;
A program for a biological information measuring device, comprising: a second step for causing the neural state measuring unit to perform measurement of an active state of an autonomic nerve function based on the pulse wave information and the activity state measuring information . A third step of causing the calculation unit to perform calculation of the nerve index value based on the pulse wave information between the first step and the second step;
In the second step, according to claim 5 to cite the nerve index value and the active measuring claims measuring the activity status of the autonomic nervous function based on the information to be executed by the neural state measurement unit 2 or at least claim 2 10 any program of the biological information measuring apparatus according to claim 11 to operate the biological information measuring apparatus according to one of.