JP6336393B6 - 硬組織用インプラント - Google Patents

硬組織用インプラント Download PDF

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Publication number
JP6336393B6
JP6336393B6 JP2014538914A JP2014538914A JP6336393B6 JP 6336393 B6 JP6336393 B6 JP 6336393B6 JP 2014538914 A JP2014538914 A JP 2014538914A JP 2014538914 A JP2014538914 A JP 2014538914A JP 6336393 B6 JP6336393 B6 JP 6336393B6
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Prior art keywords
hard tissue
implant
pillar
slot
pillar portion
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JP2014538914A
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Japanese (ja)
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JP6336393B2 (ja
JP2014534860A5 (https=
JP2014534860A (ja
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ピチャ,ジョージ,ジェイ.
トンプソン,ドーン
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/18Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/02Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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PCT/US2012/061627 WO2013063069A1 (en) 2011-10-26 2012-10-24 Hard tissue implant

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Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0918484D0 (en) * 2009-10-22 2009-12-09 Depuy Int Ltd A medical implant device
MX2014002757A (es) * 2011-09-15 2014-08-26 Amedica Corp Implantes recubiertos y metodos relacionados.
US8771354B2 (en) 2011-10-26 2014-07-08 George J. Picha Hard-tissue implant
US9526640B2 (en) 2013-08-18 2016-12-27 Boston Scientific Scimed, Inc. Anti-migration micropatterned stent coating
US10271972B2 (en) 2014-04-02 2019-04-30 Boston Scientific Scimed, Inc. Covered endoscopic stents with adhesion elements
CN105555212B (zh) * 2014-08-26 2018-11-27 瑞特医疗技术公司 具有多孔金属键的髓内支撑件
DE102015103965A1 (de) 2015-03-17 2016-09-22 Leibniz-Institut Für Neue Materialien Gemeinnützige Gmbh Komposit-Pillarstrukturen
US11744708B2 (en) * 2016-02-16 2023-09-05 Koninklijke Philips N.V. Surface topographies for altering the physiology of living cells
US10856992B2 (en) * 2016-04-27 2020-12-08 AOD Holdings, LLC Implant device(s) including tapered protrusions and method(s) for inserting the same into bone
DE102016113956A1 (de) * 2016-07-28 2018-02-01 Leibniz-Institut Für Neue Materialien Gemeinnützige Gmbh Vorrichtung mit einer strukturierten Beschichtung
EP3592283B1 (en) 2017-03-10 2024-05-08 Alps Holding Llc Hard-tissue implant comprising a bulk implant, a face, pillars, slots, and at least one support member
WO2018165405A1 (en) * 2017-03-10 2018-09-13 Applied Medical Research, Inc. Spinal interbody cage comprising a bulk interbody cage, a top face, a bottom face, pillars, and slots
WO2018165403A1 (en) * 2017-03-10 2018-09-13 Applied Medical Research, Inc. Hard-tissue stem implant comprising a bulk stem implant, a face, pillars for contacting a cancellous portion of a hard tissue, and slots, wherein the pillars are prearranged to match an underlying structure of the cancellous portion
USD840026S1 (en) * 2017-05-23 2019-02-05 AquaCast Liner LLC Padded liner
USD841799S1 (en) 2017-05-23 2019-02-26 AquaCast Liner LLC Extended liner
DE102017005618A1 (de) * 2017-06-14 2018-12-20 Johannes Scherer Dentalimplantatsystem umfassend wenigstens ein Zahnimplantat und ein separates Abutment
US11648135B2 (en) 2017-09-13 2023-05-16 Boston Scientific Scimed, Inc. Coated stent
EP3773348B1 (en) * 2018-04-10 2025-04-02 Alps Holding Llc Spinal interbody cage comprising top and bottom faces with mesh structures, pillars and slots
JP2022537873A (ja) * 2019-04-30 2022-08-31 ユニベルズィダード ドゥ ミンホ 歯科インプラント、それを得る方法およびその使用
CN110141400B (zh) * 2019-05-10 2021-06-15 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 一种软骨修复支架
WO2021050712A1 (en) * 2019-09-11 2021-03-18 Gary A. Zwick, Trustee Of The Everest Trust Uta April 20, 2017 Implant for attaching a tendon or a ligament to a hard tissue
JP7335428B2 (ja) * 2019-09-11 2023-08-29 アルプス ホールディング エルエルシー 腱または靭帯を硬組織に取り付けるための第1のセットおよび第2のセットのピラーを備えるインプラント
US12370067B2 (en) 2019-10-29 2025-07-29 Boston Scientific Scimed, Inc. Stent including anti-migration capabilities
EP4729300A2 (en) * 2020-05-29 2026-04-22 Materialise NV Implants with navigation fiducials

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE493526A (https=) * 1949-04-25
US3605123A (en) 1969-04-29 1971-09-20 Melpar Inc Bone implant
CA962806A (en) 1970-06-04 1975-02-18 Ontario Research Foundation Surgical prosthetic device
US3808606A (en) 1972-02-22 1974-05-07 R Tronzo Bone implant with porous exterior surface
US4237559A (en) 1979-05-11 1980-12-09 General Electric Company Bone implant embodying a composite high and low density fired ceramic construction
DE3322803A1 (de) * 1983-06-24 1985-01-10 Orthoplant Vertriebs-GmbH, 2800 Bremen Zementfrei implantierbare prothese mit rasterprofilierung
US4608052A (en) * 1984-04-25 1986-08-26 Minnesota Mining And Manufacturing Company Implant with attachment surface
GB8524823D0 (en) * 1985-10-08 1985-11-13 Finsbury Instr Ltd Orthopaedic implants
US4778469A (en) * 1986-11-04 1988-10-18 Pfizer Hospital Products Group Inc. Method of forming tissue ingrowth surface on surgical implants
US4865603A (en) * 1988-02-04 1989-09-12 Joint Medical Products Corporation Metallic prosthetic devices having micro-textured outer surfaces
US7534254B1 (en) * 1988-06-13 2009-05-19 Warsaw Orthopedic, Inc. Threaded frusto-conical interbody spinal fusion implants
US5236453A (en) 1990-03-09 1993-08-17 Picha George J Mammary implant and method for reducing capsule contracture
DE4133877C1 (https=) 1991-10-12 1993-05-19 S + G Implants Gmbh, 2400 Luebeck, De
US5207709A (en) 1991-11-13 1993-05-04 Picha George J Implant with textured surface
US5263953A (en) 1991-12-31 1993-11-23 Spine-Tech, Inc. Apparatus and system for fusing bone joints
US5545226A (en) 1992-05-29 1996-08-13 Porex Technologies Corp. Implants for cranioplasty
US20010039454A1 (en) 1993-11-02 2001-11-08 John Ricci Orthopedic implants having ordered microgeometric surface patterns
US5876457A (en) 1997-05-20 1999-03-02 George J. Picha Spinal implant
US6106558A (en) 1997-09-15 2000-08-22 Applied Medical Research, Inc. Neuro decompression device
DK1100417T3 (da) 1998-08-03 2004-08-02 Synthes Ag Intervertebralt allograftafstandsstykke
US7115143B1 (en) 1999-12-08 2006-10-03 Sdgi Holdings, Inc. Orthopedic implant surface configuration
KR100371308B1 (ko) 2000-08-28 2003-02-07 구자교 척추체간 유합용 보철 삽입물 및 그 삽입장치
US7018418B2 (en) 2001-01-25 2006-03-28 Tecomet, Inc. Textured surface having undercut micro recesses in a surface
EP1389978B1 (en) 2001-05-01 2009-01-07 Amedica Corporation Radiolucent bone graft
US6569201B2 (en) 2001-09-28 2003-05-27 Depuy Acromed, Inc. Hybrid composite interbody fusion device
US7192447B2 (en) 2002-12-19 2007-03-20 Synthes (Usa) Intervertebral implant
US7205051B2 (en) 2003-09-30 2007-04-17 Depuy Products, Inc. Medical implant or medical implant part
US7723395B2 (en) 2004-04-29 2010-05-25 Kensey Nash Corporation Compressed porous materials suitable for implant
KR20070004656A (ko) 2004-01-30 2007-01-09 오스테오테크, 인코포레이티드 척추 융합을 위한 임플란트 적층
US7250550B2 (en) 2004-10-22 2007-07-31 Wright Medical Technology, Inc. Synthetic bone substitute material
US20070168037A1 (en) 2006-01-13 2007-07-19 Posnick Jeffrey C Orthopedic implant
US7833204B2 (en) 2007-05-14 2010-11-16 Applied Medical Research Intramedullary access or infusion devices
WO2009022911A2 (en) 2007-08-16 2009-02-19 Cam Implants B.V. Prosthesis comprising an anti-micromotion bone-interfacing surface and method for the manufacture thereof
US20090069904A1 (en) 2007-09-12 2009-03-12 Applied Medical Research Biomaterial including micropores
JP5266069B2 (ja) 2008-02-07 2013-08-21 昭和医科工業株式会社 ケージ
WO2009108789A1 (en) 2008-02-29 2009-09-03 Vot, Llc Tibial prosthesis
US20110213467A1 (en) * 2009-01-20 2011-09-01 Zimmer, Inc. Orthopaedic implant with woven ingrowth material
US20100256758A1 (en) * 2009-04-02 2010-10-07 Synvasive Technology, Inc. Monolithic orthopedic implant with an articular finished surface
DK2253291T3 (en) 2009-05-19 2016-06-13 Nat Univ Ireland Galway The bone implants with a structure overfladeforankrende
JP5885354B2 (ja) 2010-06-08 2016-03-15 スミス アンド ネフュー インコーポレーテッド インプラントの構成要素および方法
CN103068343B (zh) 2010-07-23 2016-08-03 普里韦勒普-施皮内股份公司 手术植入物和相关成套用具
US9132021B2 (en) 2011-10-07 2015-09-15 Pioneer Surgical Technology, Inc. Intervertebral implant
US8771354B2 (en) 2011-10-26 2014-07-08 George J. Picha Hard-tissue implant
US9237950B2 (en) 2012-02-02 2016-01-19 Biomet Manufacturing, Llc Implant with patient-specific porous structure
US8843229B2 (en) 2012-07-20 2014-09-23 Biomet Manufacturing, Llc Metallic structures having porous regions from imaged bone at pre-defined anatomic locations
FR3019032A1 (fr) 2014-03-27 2015-10-02 Ps Ii Implant femoral comportant une portion de reception avec des picots d’ancrage et prothese totale de genou comprenant un tel implant femoral
GB2543717A (en) 2014-07-31 2017-04-26 Ossis Ltd Improved implant surface

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US20130110255A1 (en) 2013-05-02
US9579206B2 (en) 2017-02-28
US8771354B2 (en) 2014-07-08
CA2853479C (en) 2016-08-23
US20170119530A1 (en) 2017-05-04
US10154908B2 (en) 2018-12-18
CA2853479A1 (en) 2013-05-02
US9333081B2 (en) 2016-05-10
BR112014010164A2 (pt) 2017-04-25
JP6336393B2 (ja) 2018-06-06
US20140277559A1 (en) 2014-09-18
WO2013063069A1 (en) 2013-05-02
US20160213475A1 (en) 2016-07-28
BR112014010164B1 (pt) 2021-05-18
JP2014534860A (ja) 2014-12-25
EP2757999A1 (en) 2014-07-30

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