JP6180016B2 - Biological cell and skin care equipment using atmospheric pressure plasma - Google Patents

Description

  The present invention relates to a biological cell and skin system care method and care apparatus using atmospheric pressure plasma.

  As described in Patent Document 1, atmospheric pressure plasma, which is often used for etching and coating in industrial applications, is expected to be applied to medical and cosmetic applications.

  Patent Document 1 mentions that by irradiating a bleeding site of a mouse with a helium plasma jet, blood coagulation occurs within a few seconds after irradiation to block the bleeding part and stop bleeding.

  In this way, plasma has a great influence on biological tissues, and it stimulates biological cells such as animal cells and plant cells and the outer skin system such as skin, hair, nails, feathers, and scales, and penetrates chemical components. The biological cells using plasma, such as activating the biological cells and the integument system, or adding the material contained in the plasma or coating the surface of the integument system with the substance It is expected to be applied to skin care.

  In the present specification, the care for biological cells and the integumentary system means that the biological cells and the integumental system are stimulated or penetrated by plasma or substances in the plasma. Activating, disinfecting unnecessary bacteria attached to the surface of biological cells and integumental systems to clean them, adding substances contained in plasma to the surfaces of biological cells and integumentary systems Modifying with a substance or forming a thin film with the substance and applying a coating to protect the biological cells and the integument system, or applying an agent to the surface of the organism cell and the integument system It shows that a substance produced by chemically reacting with the above acts on the biological cell and the integument system.

  In particular, as shown in FIGS. 8 to 10, the present inventors conducted plasma irradiation experiments on skin pigmentation, wound scars (keloids) and pimples using atmospheric pressure plasma generated from oxygen gas. It was confirmed that atmospheric pressure plasma has an excellent effect on these symptoms. The portion surrounded by the broken line is the irradiation target part. In the irradiation experiment of FIG. 8, atmospheric pressure plasma is irradiated once a week for a total of four times. In the irradiation experiment of FIG. Irradiation is performed once a week for a total of 4 times, and in the irradiation experiment of FIG. 10, atmospheric pressure plasma is irradiated once, and the state of the affected area before irradiation, 2 weeks later, 1 month later, or the next day, respectively. Observed. In this way, atmospheric pressure plasma moderately stimulates living cells such as animal cells and plant cells, and skin systems such as skin, and chemical components such as active species contained in atmospheric pressure plasma penetrate biological cells and skin systems. Thus, the present invention has been achieved in view of excellent effects on biological cells and the outer skin system.

Japanese Unexamined Patent Publication No. 2011-0224

  In the treatment and beauty treatment using plasma, treatment is performed by directly irradiating the patient's body with plasma, and depending on the type of plasma generating gas used to generate plasma, it may have a unique odor or enter the eyes. And had problems such as feeling irritation. Furthermore, when using a plasma generating gas with a special component, there is a concern that it may cause a chemical reaction with the irradiation target to generate a by-product, which has a secondary effect on the irradiated area and the surrounding area. The

  In addition, the lifetime of active species in atmospheric pressure plasma is short, and it immediately changes to a stable state, so that the generated plasma can quickly reach the site to be irradiated and can be highly effective in a shorter care time. Realization is required.

  Therefore, the present invention does not affect biological cells and the outer skin system that do not require care, and can only care for biological cells and outer skin systems that require care with atmospheric pressure plasma, enabling high-density plasma irradiation. It is an object of the present invention to provide a biological cell and skin system care method using atmospheric pressure plasma and a biological cell and skin system care apparatus using atmospheric pressure plasma.

A first aspect of a biological cell and integument-based care device using atmospheric pressure plasma of the present invention includes a plasma generation unit that generates an atmospheric pressure plasma containing active species by ionizing a plasma generating gas under atmospheric pressure. A plasma injection unit for injecting the atmospheric pressure plasma generated by the plasma generation unit to a surface of a living cell and an outer skin system made of a single body or an assembly; and a jet of the plasma injection unit to contact the biological cell and the outer skin system A gas exhaust section for exhausting the atmospheric pressure plasma after the gas circulation is performed, and a gas including atmospheric pressure plasma exhausted from the plasma exhaust section is introduced into the plasma generation section, and the gas is used as a plasma generation gas. And a mechanism .

According to the first aspect of the biological cell and outer skin care device using atmospheric pressure plasma of the present invention, by providing the exhaust part, it is possible to prevent the atmospheric pressure plasma from hitting other than the irradiation target site and giving a stimulus. In addition to smoothing the flow of atmospheric pressure plasma and allowing the generated atmospheric pressure plasma to quickly reach biological cells and the integument system, it is possible to always contact the target site with high-density plasma. And Furthermore, by providing a gas circulation function, it is possible to generate more dense atmospheric pressure plasma because it can be further ionized in a state where the active species in the atmospheric pressure plasma remain, and extra Consumption of the plasma generating gas can be suppressed.

  The second aspect of the biological cell and integumental care device using atmospheric pressure plasma according to the present invention is to contact the surface of the living cell and integument system while convection of the atmospheric pressure plasma introduced from the plasma injection unit. A plasma contact portion is formed by covering a part or the whole of the living cell and the outer skin system, and the plasma exhaust portion is connected to the biological cell and the outer skin system from the plasma contact portion of the surrounding ring portion. It is characterized in that it is formed so as to discharge atmospheric pressure plasma after contact with the substrate.

  According to the second aspect of the biological cell and integumental care device using atmospheric pressure plasma of the present invention, the biological cell and the integument system are partially or wholly covered while the atmospheric pressure plasma is convected. By providing an encircling part that forms a plasma contact part that brings the plasma into contact with the surface of biological cells and the outer skin system, it is possible to prevent atmospheric pressure plasma from contacting other than the irradiation target site and to diffuse atmospheric pressure plasma. Can be prevented, generation of odor of atmospheric pressure plasma can be suppressed, and high-density atmospheric pressure plasma can be maintained.

  According to a third aspect of the biological cell and integumental care device using atmospheric pressure plasma of the present invention, a mist introduction part for introducing a drug and / or water vapor into the surrounding ring part is provided. .

  According to the third aspect of the biological cell and integumental care device using atmospheric pressure plasma of the present invention, the biological cell and integumentary care using a desired drug by providing a mist introduction part in the surrounding ring part Enables care of biological cells and integuments in wet and moist conditions.

  According to a fourth aspect of the biological cell and integumental care device using atmospheric pressure plasma of the present invention, the encircling portion observes the potential change of the encircling portion and the biological cell and the integument system A contact sensing mechanism for sensing whether or not the surrounding ring portion is in contact is provided.

  According to the fourth aspect of the biological cell and outer skin care device using atmospheric pressure plasma of the present invention, by providing a contact sensing mechanism, for example, in the case of performing treatment on the human body, the presence or absence of contact is determined. It is possible to prevent the atmospheric pressure plasma from being inadvertently injected.

  According to the biological cell and integumental care method using atmospheric pressure plasma of the present invention, it provides a versatile care method that does not cause unpleasant odor or irritation other than the irradiation target site, and has a high density. High-speed care is possible by the atmospheric pressure plasma.

  In addition, according to the biological cell and integumental care device using atmospheric pressure plasma of the present invention, the generation of unpleasant odor is suppressed, and the stimulation is not caused to the part other than the irradiation target part, and in a shorter time than the care method. Make it possible to realize

Sectional drawing which shows 1st Embodiment of the biological cell and the outer skin type care apparatus using the atmospheric pressure plasma of this invention Sectional drawing which shows 2nd Embodiment of the care apparatus of the biological cell and outer skin type | system | group using the atmospheric pressure plasma of this invention Sectional drawing which shows the other aspect of 2nd Embodiment of this invention. Sectional drawing which shows 3rd Embodiment of the care apparatus of the biological cell using the atmospheric pressure plasma of this invention, and a skin system Sectional drawing which shows 4th Embodiment of the care apparatus of the biological cell which uses the atmospheric pressure plasma of this invention, and a skin system Sectional drawing which shows 5th Embodiment of the biological cell and outer_shell | care system care apparatus using the atmospheric pressure plasma of this invention It is sectional drawing which shows other embodiment of the care apparatus of the biological cell using the atmospheric pressure plasma of this invention, and a skin system, (a) is a longitudinal cross-sectional view, (b) is AA sectional drawing in (a). In the preceding experiments by the present inventors, the photographs show the effect of atmospheric pressure plasma on the arrival of new dyes, (a) before irradiation, (b) two weeks after the start of irradiation, and (c) one month after the start of irradiation. In the preceding experiment of the present inventors, it is a photograph showing the effect of atmospheric pressure plasma on a wound scar (keloid), (a) before irradiation, (b) two weeks after the start of irradiation, (c) the start of irradiation. One month later In the preceding experiments by the present inventors, the photographs show the effect of atmospheric pressure plasma on the blowout, (a) is before irradiation, (b) is the day after irradiation, (c) is two weeks after irradiation, (d) is 1 month after irradiation

  Specific embodiments of the biological cell and integument care method using atmospheric pressure plasma and the biological cell and integument care device using atmospheric pressure plasma of the present invention will be described below with reference to FIGS. 1 to 6. explain in detail.

  The biological cell and integumental care method using atmospheric pressure plasma of the present invention is a treatment for biological cells such as animal cells and plant cells, and integument systems such as skin, hair, nails, feathers and scales, or cosmetic purposes. In order to perform care such as sterilization of microorganisms and protection by coating, the plasma generating gas is ionized at atmospheric pressure to generate atmospheric pressure plasma containing active species, and the atmospheric pressure plasma is a single substance or an aggregate. Irradiate the surface of the cell and the integument system and / or place the biological cell and the integument system in a plasma atmosphere to bring the atmospheric pressure plasma into contact with the surface of the biological cell and the integument system. While evacuating, the biological cells and the integument system are stimulated by active species, and the chemical components in the atmospheric pressure plasma are transferred into the in vivo cells and the integument system. Protect by permeating, disinfecting the surface of biological cells and integumentary systems, adding or modifying substances contained in atmospheric plasma to the surfaces of biological cells and integumental systems, or forming a thin film with the substances and coating them Or a substance generated by applying a chemical to the surface of biological cells and the outer skin system and causing the chemical to react with atmospheric pressure plasma.

  In the present specification, a biological cell refers to a single cell of a biological cell or a multicellular organism composed of a single cell such as a human, animal, or plant. The integument system is an organ that distinguishes and separates organisms such as humans, animals, and plants from the outside world, and indicates, for example, skin, hair, nails, feathers, scales, and the like. It should be noted that the integument system is not limited to the above-described one, and any organ may be used as long as it separates organisms from the outside world, such as an exoskeleton formed attached to the skin.

  In the biological cell and integument system care method using the atmospheric pressure plasma of the present invention, the atmospheric pressure plasma after contacting the organism cell and the integument system is exhausted. The medical purpose of biological cells and integumentary systems without causing unpleasant odors and non-irradiated parts generated by contact of gas, biological cells, and integumentary systems with atmospheric pressure plasma, and other than irradiation target sites. It enables effective care such as treatment for cosmetic purposes, sterilization of microorganisms and protection of biological cells and integument system by coating. In addition, by exhausting atmospheric pressure plasma after contact with biological cells and the outer skin system, the flow of atmospheric pressure plasma used for care is smoothed, and active species that have just been generated are contained in high density. By allowing the atmospheric pressure plasma to reach the biological cells and the integument system quickly, it is always possible to bring the high-density atmospheric pressure plasma into contact with the target site, and it is possible to realize excellent care effects in a short time To do.

  Specific embodiments of the biological cell and integument system care device using the atmospheric pressure plasma of the present invention for realizing the above biological cell and integument system care method using the atmospheric pressure plasma of the present invention, This will be described in detail below with reference to FIGS. In the following description of the present embodiment, biological cells will be described as care targets. However, the present invention is not limited to this, and the same care apparatus can be applied to the outer skin system. In addition, the plasma generation unit will be described using a configuration in which atmospheric pressure plasma is generated using dielectric barrier discharge, but is not limited to this, and a configuration using glow discharge or arc discharge is used under atmospheric pressure. Any structure can be used as long as it can generate plasma.

  First, as shown in FIG. 1, the first embodiment of the care device 1 of the present invention includes an inner electrode 4 a provided inside a cylindrical insulating portion 3 and an inner electrode across the insulating portion 3. 4a and an outer electrode 4b provided on the outer peripheral surface of the insulating portion 3 so as to be opposed to the plasma generating gas introduced into the insulating portion 3 under atmospheric pressure (in the figure, Gas and A plasma generation unit 2 that generates an atmospheric pressure plasma P containing active species by ionizing.

  The insulating part 3 has a shaft part 3 a that forms the plasma generating part 2 and a protruding part 3 b that is formed in a cup shape that opens toward the living cell C. The protruding part 3 b is generated in the plasma generating part 2. The plasma atmospheric pressure plasma P is applied to the surface of the biological cell C as a plasma injection unit 5.

  In addition, a plasma exhaust part 6 is formed at the connection part between the shaft part 3a and the projecting part 3b to exhaust the atmospheric pressure plasma P after being ejected from the plasma ejecting part 5 and coming into contact with the living cells C. Yes.

  The plasma exhaust unit 6 includes one or a plurality of exhaust ports 6a, and the plasma injection unit 5 exhausts the atmospheric pressure plasma P after contacting the living cell C in a direction not contacting the living cell C. Is formed.

  In the care device 1 of the present embodiment, dielectric barrier discharge is generated by introducing a plasma generating gas with the outer electrode 4b grounded and a predetermined voltage applied to the inner electrode 4a, thereby generating plasma. A substance in the working gas is ionized to generate an atmospheric pressure plasma P containing active species of the substance. In this state, the atmospheric pressure plasma P introduced into the plasma injection unit 5 by the gas flow of the plasma generating gas by pressing the opening 3c of the protrusion 3b against a predetermined part of the biological cell C is converted into the plasma injection unit 5 While being in convection, it contacts the living cell C and is exhausted from the exhaust port 6a of the plasma exhaust unit 6 by the flow.

  By setting it as the care apparatus 1 of 1st Embodiment like this, it can prevent that the atmospheric pressure plasma P injected is irradiated other than irradiation object site | part, for example, it is sensitive to irritation | stimulations, such as a face Even in the case where care is given to various parts, it is possible to perform skin care without causing discomfort such as eye sight.

  Further, by exhausting from the plasma exhaust unit 6, the flow of the atmospheric pressure plasma P is smoothed to maintain the flow rate of the atmospheric pressure plasma P, and the plasma injection unit 5 of the atmospheric pressure plasma P generated in the plasma generation unit 2. By extremely shortening the time from jetting to the surface of the biological cell C, the atmospheric pressure plasma P containing active species at a high density can be brought into rapid contact with the surface of the biological cell C. As a result It makes it possible to give excellent care in a short time.

  In addition, as shown in FIG. 2, the second embodiment of the care device 1 of the present invention separates the insulating portion 3 from the tubular insulating portion 3, the inner electrode 4 a provided inside the insulating portion 3, and the insulating portion 3. The plasma generation unit 2 having the outer electrode 4b provided on the outer peripheral surface of the insulating unit 3 so as to face the inner electrode 4a and a part or the whole of the biological cell C are covered while the atmospheric pressure plasma P is convected. A plasma contact portion 7a for bringing plasma into contact with the surface of the biological cell C is formed, and a cylindrical surrounding portion 7 including at least a plasma injection portion 5 provided at the tip of the plasma generation portion 2 is provided.

  In the present embodiment, the surrounding portion 7 and the plasma generating portion 2 are connected to each other with the gap 6b serving as the plasma exhaust portion 6 provided between the outer peripheral surface of the outer electrode 4b and the inner peripheral surface of the surrounding portion 7. The atmospheric pressure plasma P is exhausted by disposing the well-known exhaust mechanism 6c on the apparatus main body side (upper side in FIG. 2) of the surrounding ring portion 7 disposed on the concentric shaft.

  Further, a buffer member 7b made of a highly elastic material such as silicon rubber is provided in a portion of the surrounding ring portion 7 that comes into contact with the biological cell C in order to reduce the pressing force on the biological detail C. Furthermore, the surrounding ring portion 7 can be visually checked for the presence or absence of lighting of the atmospheric pressure plasma P, the state of care, etc. by using a translucent material. Can protect the eyes.

  In the care device 1 of the present embodiment, dielectric barrier discharge is generated by introducing a plasma generating gas with the outer electrode 4b grounded and a predetermined voltage applied to the inner electrode 4a, thereby generating plasma. A substance in the working gas is ionized to generate an atmospheric pressure plasma P containing active species of the substance. The atmospheric pressure plasma P generated in the plasma generation unit 2 is ejected from the plasma ejection unit 5 by the gas flow of the plasma generation gas, and is ejected onto the surface of the biological cell C. At this time, the plasma contact part 7 a forms a closed space surrounded by the surrounding ring part 7 and the biological cell C by bringing the buffer member 7 b into close contact with the surface of the biological cell C, and is ejected from the plasma ejection part 5. The atmospheric pressure plasma P is brought into contact with the surface of the biological cell C while being convected in the plasma contact portion 7a. The atmospheric pressure plasma P in contact with the biological cell C is exhausted from the exhaust mechanism 6c through the gap 6b.

  By setting it as the care apparatus 1 of 2nd Embodiment like this, while being able to prevent the atmospheric pressure plasma P injected from being irradiated to other than the irradiation target site, it is exhausted via the exhaust mechanism 6c. Therefore, care can be performed without feeling unpleasant due to odor that occurs when the substance in the plasma generating gas is ionized or when the atmospheric pressure plasma P contacts the living cell C. .

  Further, by exhausting from the plasma contact portion 7a by the plasma exhaust portion 6, convection of the atmospheric pressure plasma P in the plasma contact portion 7a is promoted and the flow of the atmospheric pressure plasma P is made smooth by smoothing the flow of the atmospheric pressure plasma P. Maintaining and containing active species at high density by extremely shortening the time from the injection of the atmospheric pressure plasma P generated in the plasma generation unit 2 from the plasma injection unit 5 to the surface of the biological cell C The atmospheric pressure plasma P can be quickly brought into contact with the surface of the biological cell C, and as a result, excellent care can be performed in a short time.

  Furthermore, as shown in FIG. 2, the surrounding ring portion 7 is disposed so as to protrude from the tip of the plasma ejection portion 5 of the plasma generating portion 2, thereby irradiating the surface of the living cell C with the atmospheric pressure plasma P. Can be kept constant, so that it is possible to perform desired care regardless of the skill level of the user.

  In addition, the protrusion amount from the front-end | tip part of the plasma ejection part 5 of the surrounding ring part 7 is set to arbitrary protrusion amounts by applying a well-known screwing type or push-in movable type variable mechanism to the surrounding ring part 7. Further, the irradiation distance of the atmospheric pressure plasma P can be appropriately changed according to the type of plasma generating gas used, the state of the irradiation target, and the like.

  Moreover, as for the other aspect of 2nd Embodiment, as shown in FIG. 3, the front-end | tip part which opposes the biological cell C of the surrounding ring part 7 is formed in the taper shape or the mortar-shaped taper shape. Thereby, the directivity of the atmospheric pressure plasma P is improved, and care for a very limited range in the living cell C is enabled.

  Furthermore, one or a plurality of leak ports 7c that allow inflow of air from the outside of the surrounding portion 7 are provided on the side wall portion of the surrounding portion 7, and the surrounding portion 7 is inhaled by intake air by the exhaust mechanism 6c. It is possible to prevent the inside of the cell from being excessively depressurized and the surface of the biological cell C sticking to the opening of the surrounding ring part 7 to cause adsorption marks. In particular, as shown in FIG. 3, the leak port 7c is provided with a check valve 7d to prevent the atmospheric pressure plasma P from leaking to the outside.

  In this embodiment, the check valve 7d is provided to prevent the atmospheric pressure plasma P from leaking to the outside, but the suction amount of the exhaust mechanism 6c is not provided without providing the check valve 7d. The atmospheric pressure plasma P may be prevented from leaking to the outside by adjusting.

  Further, as shown in FIG. 4, the care device 1 according to the third embodiment of the present invention has a tubular insulating part 3, an inner electrode 4 a provided on the inner side of the insulating part 3, and the inner part across the insulating part 3. The plasma generating unit 2 having the outer electrode 4b provided on the outer peripheral surface of the insulating unit 3 so as to face the electrode 4a, and a part or the whole of the biological cell C are covered, while the atmospheric pressure plasma P is convected while living A plasma contact portion 7a for bringing plasma into contact with the surface of the cell C is formed, and at least a plasma injection portion 5 provided at the front end of the plasma generation portion 2 is provided.

  A mist introducing portion 8 for introducing a drug and / or water vapor into the plasma contact portion 7 a in the surrounding portion 7 is provided inside the surrounding portion 7. The mist introduction unit 8 includes a mist introduction tube 8a made of a glass tube and the like, and a mist mechanism 8b for mist-forming the medicine and / or water. The mist introduction tube 8a is formed into a mist as shown in FIG. The distal end portion 8c from which the medicine and / or water spouted is directed toward the living cell C and is disposed inside the surrounding ring portion 7.

  At this time, as shown in FIG. 4, the plasma generation unit 2 and the mist introduction pipe 8 a are formed in the ring portion 7 so as to form a gap 6 b as the plasma exhaust portion 6 in the vicinity of the inner peripheral surface of the ring portion 7. It is arranged close to the shaft center. The atmospheric pressure plasma P ejected from the plasma ejection part 5 and in contact with the living cells C and excess mist are exhausted from the exhaust mechanism 6c through the gap 6b.

  In the care device 1 of the present embodiment, dielectric barrier discharge is generated by introducing a plasma generating gas with the outer electrode 4b grounded and a predetermined voltage applied to the inner electrode 4a, thereby generating plasma. A substance in the working gas is ionized to generate an atmospheric pressure plasma P containing active species of the substance. The atmospheric pressure plasma P generated in the plasma generation unit 2 is ejected from the plasma ejection unit 5 by the gas flow of the plasma generation gas, and is ejected onto the surface of the biological cell C. At this time, a mist-like drug and / or water is introduced into the atmospheric pressure plasma P ejected from the plasma jetting unit 5, and the atmospheric pressure plasma P and the mist-like drug and / or water vapor are brought into contact with the biological cell C. It is supposed to let you. Then, the atmospheric pressure plasma P and the excessive mist-like drug and / or water vapor that have come into contact with the living cells C are exhausted from the exhaust mechanism 6c through the gap 6b.

  By using the care device 1 of the third embodiment as described above, it is possible to perform care with atmospheric pressure plasma P while performing medication, or to perform care in a wet state with water vapor. It is also possible to perform care by causing a chemical reaction between the introduced mist-like drug and / or water vapor and atmospheric pressure plasma P.

  Further, in addition to the mist-like drug and / or water vapor, a gas made of a material different from the plasma generating gas for improving the care effect is introduced from the mist introducing portion 8 or a gas made of the same material as the plasma generating gas. By introducing, effects can be added according to the care target, or a higher-density atmospheric pressure plasma P can be obtained, and various cares for biological cells C can be realized.

  Further, as shown in FIG. 4, by providing a contact sensing mechanism 9 as a touch sensor including an electrometer 9 a in the surrounding ring portion 7, it is detected whether the surrounding ring portion 7 is in contact with the living cell C or not. Thus, for example, when the surrounding ring part 7 is in contact with the biological cell C, the plasma generating gas is introduced to generate and eject the atmospheric pressure plasma P, so that the user's Contrary to the intention, it is possible to prevent the atmospheric pressure plasma P from being injected.

  At this time, in the contact sensing mechanism 9, monitoring is performed by applying a band-pass filter at the plasma lighting frequency in the plasma generation unit 2, or a signal having an observation frequency different from the plasma lighting frequency is input. Whether the atmospheric pressure plasma P is reliably irradiated on the biological cell C as well as sensing the contact of the surrounding ring part 7 with the biological cell C by observing the potential change by monitoring It is possible to examine whether or not the atmospheric pressure plasma P having a certain intensity is irradiated, and whether or not a dangerous current flows to the living cell C.

  Furthermore, a thermometer 10a for measuring the temperature of the atmospheric pressure plasma P in the gap 6b, a gas temperature adjusting unit 10b for adjusting the temperature of the plasma generating gas, and a gas temperature adjusting unit 10b according to the temperature from the thermometer 10a. By providing the temperature adjustment mechanism 10 including the control unit 10c for controlling the temperature, the temperature of the atmospheric pressure plasma P contacting the living cell C is observed from the temperature of the exhausted atmospheric pressure plasma P, and the temperature is adjusted to the temperature. Accordingly, by controlling the temperature of the atmospheric pressure plasma P, care using the atmospheric pressure plasma P at a desired temperature can be performed.

  Further, as shown in FIG. 5, the fourth embodiment of the care device 1 according to the present invention has a circular tubular insulating portion 3, an inner electrode 4 a provided inside the insulating portion 3, and the insulating portion 3 on the inner side. The plasma generating unit 2 having the outer electrode 4b provided on the outer peripheral surface of the insulating unit 3 so as to face the electrode 4a, and a part or the whole of the biological cell C are covered, while the atmospheric pressure plasma P is convected while living A plasma contact portion 7a for bringing plasma into contact with the surface of the cell C is formed, and at least a plasma injection portion 5 provided at the front end of the plasma generation portion 2 is provided.

  Further, the surrounding ring portion 7 and the plasma generating portion 2 are arranged concentrically with a gap 6b as the plasma exhausting portion 6 provided between the outer peripheral surface of the outer electrode 4b and the inner peripheral surface of the surrounding ring portion 7. On the apparatus main body side (upper side in FIG. 2) of the surrounding ring portion 7, a known exhaust mechanism 6 c that exhausts atmospheric pressure plasma P from the gap 6 b and a gas introduction portion that introduces a plasma generating gas into the plasma generating portion 2. The gas circulation mechanism 11 having 12 is provided.

  The gas circulation mechanism 11 includes a gas recovery path 11a for exhausting the used atmospheric pressure plasma Pu after contacting the living cell C in the plasma contact portion 5 from the gap 6b and recovering it to the exhaust mechanism 6c, and an exhaust mechanism 6c. A reuse gas supply path 11g for supplying the collected used atmospheric pressure plasma Pu to the gas introduction unit 12;

  In the care apparatus 1 of the present embodiment, an unused plasma generating gas is supplied from the gas supply unit (not shown) to the gas introduction unit 12 with the outer electrode 4b grounded and a predetermined voltage applied to the inner electrode 4a. As a result, dielectric barrier discharge is generated, and the substance in the plasma generating gas is ionized to generate atmospheric pressure plasma P containing active species of the substance. The atmospheric pressure plasma P generated in the plasma generation unit 2 is ejected from the plasma ejection unit 5 by the gas flow of the plasma generation gas, and is ejected onto the surface of the biological cell C. Then, the used atmospheric pressure plasma Pu once contacted with the biological cell C is recovered from the gap 6b to the exhaust mechanism 6c via the gas recovery path 11a and supplied to the gas introduction unit 12 from the reuse gas supply path 11b. Then, it is introduced again into the plasma generator 2 to generate the atmospheric pressure plasma P.

  By using the care device 1 according to the fourth embodiment as described above, substances in the used atmospheric pressure plasma Pu are ionized to generate more active species, and further increase the activity of the remaining active species. Therefore, it is possible to generate high-density atmospheric pressure plasma P and perform high-speed care.

  Further, by reusing the used atmospheric pressure plasma Pu, the consumption of plasma generating gas can be reduced, and the cost for care can be reduced. Furthermore, even when the plasma generating gas or the generated atmospheric pressure plasma P includes a substance that causes a chemical reaction with air to generate a harmful substance or a substance that reduces the care effect, Since the plasma generating gas or the atmospheric pressure plasma P can be prevented from coming into contact with air, safe and effective care can be performed.

  In addition, in addition to the used atmospheric pressure plasma Pu, the gas introduction unit 12 supplies unused plasma generation gas from a gas supply unit (not shown), and the used atmospheric pressure is supplied to the plasma generation unit 2. A mixed gas of plasma Pu and unused plasma generating gas may be introduced. By generating atmospheric pressure plasma P from the mixed gas, it is included in atmospheric pressure plasma P by contacting biological cells C. Even when care is taken such that a substance that acts on the living cell C is consumed, the substance in the atmospheric pressure plasma P can be added by mixing unused plasma generating gas. It is always possible to achieve a high care effect.

  Moreover, 5th Embodiment of the care apparatus 1 of this invention is formed so that the surrounding ring part 7 is made into the bag-like mittens part 13 and it covers the whole hand as the biological cell C, as shown in FIG. Has been. The mittens unit 13 includes a plasma injection port 14 as a plasma injection unit 5 for introducing the atmospheric pressure plasma P generated in the plasma generation unit 2 (not shown) into the inside, and the atmospheric pressure after contacting the hand. An exhaust port 6a is formed as a plasma exhaust unit 6 for leading the plasma P to the exhaust mechanism 6c. In addition, as the plasma generation part 2, what was demonstrated in the above-mentioned 1st Embodiment thru | or 3rd Embodiment can be used.

  In the care device 1 of the present embodiment, as shown in FIG. 6, atmospheric pressure plasma P is introduced into the mittens part 13 from a plasma injection port 14 provided in the vicinity of the wrist, and atmospheric pressure is generated inside the mittens part 13. The plasma P is brought into contact with the surface of the hand as a biological cell C while being convected, and the atmospheric pressure plasma P after contacting the surface of the hand from the exhaust port 6a provided near the fingertip is exhausted to the exhaust mechanism 6c. ing.

  By using the care device 1 according to the fifth embodiment as described above, the plasma contact portion 7a is formed so as to cover the entire care target by the mittens portion 13 as the surrounding ring portion 7, thereby enabling a wide range in a short time. It makes it possible to perform care. The surrounding ring portion 7 in the present embodiment is not limited to the mittens portion 13, for example, a hat shape that covers the hair portion, or in the case of a human body or an animal, a respirator is passed inside, In the case of a plant, it is possible to adopt a mode such as a shape that covers the whole by including a recreation part for replenishing water inside.

  Further, in another embodiment of the care device 1 of the present invention, as shown in FIGS. 7A and 7B, the surrounding ring portion 7 is formed of a solid ellipse bar, and one curved portion in the major axis direction of the ellipse. A through hole 7e through which the plasma portion injection 5 is inserted is formed on the right side in FIG. 7B, and the other curved portion (left side in FIG. 7B) is in contact with the surface of the biological cell C. An exhaust port 6a for exhausting the atmospheric pressure plasma P is formed. Further, a side wall portion 7f is provided at the front end portion of the surrounding ring portion 7 in the direction of the biological cell C (lower side in FIG. 7A) to provide a plasma contact portion 7a for contacting the biological cell C with the atmospheric pressure plasma P. Is formed so as to protrude by a predetermined amount, and a buffer member 7b made of a highly elastic material such as silicon rubber is provided at the tip of the portion that contacts the living cell C in order to reduce the pressing force on the living cell C. Is provided.

  In the present embodiment, the surrounding ring portion 7 is an elliptical bar, but any shape that surrounds the irradiation target portion with a predetermined distance between the plasma injection portion 5 and the exhaust port 6a may be used. For example, a rectangular bar having a rectangular cross section may be used.

  In the care device 1 of the present embodiment, as shown in FIG. 7A, the atmospheric pressure plasma P generated in the plasma generation unit 2 is injected from the plasma injection unit 5 to the plasma contact unit 7 a and is applied to the living cell C. The atmospheric pressure plasma P after contact is sucked by the exhaust mechanism 6c and exhausted from the plasma contact portion 7a through the exhaust port 6a, so that the unidirectionality in the major axis direction of the ellipse is formed in the plasma contact portion 7a. The atmospheric pressure plasma P is brought into contact with the living cell C in a state where a flow is formed.

  By using the care device 1 of such other embodiments, the atmospheric pressure plasma P can be flowed at high speed in the major axis direction of the ellipse at the plasma contact portion 7a. In addition, since the active species having a short lifetime can be reliably contacted with the living cells C in the range surrounded by the encircled portion while being in an active state, it is possible to provide care to a wide range of sites at once. To do.

  According to the care device 1 of the present invention as described above, it is possible to prevent stimulation other than the irradiation target site and to cause unpleasantness caused by the chemical reaction between the atmospheric pressure plasma P or the atmospheric pressure plasma P and the biological cell C. It is possible to realize a general-purpose care device that suppresses odor, and to maintain the flow rate of the atmospheric pressure plasma P by smoothing the flow of the atmospheric pressure plasma P, and to generate the atmospheric pressure plasma generated in the plasma generator 2. By extremely shortening the time from the injection of P from the plasma injection unit 5 to the surface of the biological cell C, the atmospheric pressure plasma P containing active species at a high density is brought into rapid contact with the surface of the biological cell C. As a result, it is possible to provide excellent care in a short time.

  Further, by applying the care device 1 of the present invention to an endoscope or laparoscopic treatment tool, without leaving the gas jetted in the living body, and further, against the pinpoint irradiation target site in the living body Thus, it is possible to achieve excellent effects such as enabling treatment and treatment using atmospheric pressure plasma.

  The care device 1 of the present invention is not limited to the first to fifth embodiments, and various modifications can be made without departing from the characteristics of the invention. For example, a leak port 7c is provided. Instead, the pressure on the gas supply side is made larger than the pressure on the exhaust side, and the inside of the plasma contact portion 7a is used as a pressurized state, or conversely, the pressure on the exhaust side is supplied. The inside of the plasma contact portion 7a can be used as a reduced pressure state.

  Further, in the present embodiment, the temperature is controlled by the temperature control mechanism 10 using the thermometer 10a, but by adopting a configuration in which the light of the atmospheric pressure plasma P is observed using an optical fiber, It is possible to change the temperature of the generated atmospheric pressure plasma P by monitoring the temperature, density, presence / absence of lighting, and controlling the temperature.

  Furthermore, in the present embodiment, an embodiment in which one plasma generation unit 2 is provided is described, but a configuration in which a plurality of plasma generation units 2 are provided may be used, and each plasma generation unit 2 may be configured according to the application. By generating different atmospheric pressure plasmas P, it is possible to care for biological cells and integuments using two or more types of atmospheric pressure plasmas P.

DESCRIPTION OF SYMBOLS 1 Care apparatus 2 Plasma generation part 3 Insulation part 5 Plasma injection part 6 Plasma exhaust part 7 Enclosure part 7a Plasma contact part 8 Mist introduction part 9 Contact sensing mechanism 11 Gas circulation mechanism C Biological cell P Atmospheric pressure plasma Gas Gas for plasma generation

Claims (4)

A plasma generating unit for generating an atmospheric pressure plasma containing active species by ionizing a plasma generating gas under atmospheric pressure;
A plasma injection unit for injecting the atmospheric pressure plasma generated by the plasma generation unit onto the surface of a living cell and an outer skin system consisting of a single body or an assembly; and
A plasma exhaust unit for exhausting atmospheric pressure plasma after being injected from the plasma injection unit and contacting the living cells and the outer skin system ;
A living body using atmospheric pressure plasma, comprising a gas circulation mechanism that introduces a gas containing atmospheric pressure plasma discharged from the plasma exhaust section into the plasma generation section and uses the gas as a plasma generation gas. Cell and integumental care device. An encircling formed by covering a part or the whole of the living cell and the outer skin system with a plasma contact portion for contacting the surface of the living cell and the outer skin system while convection of the atmospheric pressure plasma introduced from the plasma spraying portion Part
The plasma exhaust unit, according to claim 1, characterized in that it is formed so as to discharge the atmospheric pressure plasma after from the plasma contacting portion of the囲環portion in contact with the biological cells and integumentary system Biological cell and skin care equipment using atmospheric pressure plasma. The biological cell and skin system care device using atmospheric pressure plasma according to claim 2 , further comprising a mist introduction part for introducing a drug and / or water vapor into the surrounding part. The encircling part is provided with a contact sensing mechanism for observing changes in the potential of the encircling part and sensing whether the encircling part is in contact with the living cells and the outer skin system. A biological cell and integumental care device using the atmospheric pressure plasma according to claim 2 or 3 .