JP6137450B2 - Endoscope for colorectal cancer detection - Google Patents

Description

  The present invention relates to an endoscope.

The endoscope has a forceps opening communicating with the forceps channel, and an endoscope treatment tool such as forceps is inserted into the forceps channel. Such an endoscope can collect and remove a tumor inside an observation target via an endoscope treatment tool (see, for example, Patent Document 1).
Thus, the endoscope has a function as an instrument for treating and treating a patient as well as acquiring visual information inside the observation target.

JP 2012-200415 A

  In recent years, multi-functionality is required for endoscopes, and a technique for complementing information obtained from endoscopy is required.

  The present invention has been made in view of the above circumstances, and an endoscope capable of obtaining quantitative information based on measurement of iron ion concentration in real time in addition to qualitative visual information in colonoscopy The purpose is to provide.

In order to solve the above-mentioned problems, the present inventors have conducted extensive research and found that the problems can be solved by an endoscope provided with an iron sensor for analyzing a digestive tract washing liquid derived from a subject. One embodiment of the present invention provides the following (1) to (5).
(1) colon cancer detection endoscope of the present invention is at least partially introduced into a body cavity of a subject, an endoscope for imaging the interior of objects of the subject, gut from said subject An iron sensor that measures the concentration of iron ions in the cleaning solution in real time is provided.
(2) In the endoscope for detecting colorectal cancer of the present invention, the iron sensor preferably includes an ion selective electrode.
(3) The endoscope for detecting colorectal cancer of the present invention preferably includes a liquid absorption tank, and the iron sensor is provided in the liquid absorption tank.
(4) The endoscope for detecting colorectal cancer of the present invention preferably includes the iron sensor at a tip portion introduced into the observation target.
(5) The endoscope for detecting colorectal cancer of the present invention is preferably a capsule type.

  According to the present invention, in addition to qualitative visual information, quantitative information based on iron ion concentration measurement can be obtained in real time.

It is explanatory drawing of an iron ion concentration measurement using an ion selective electrode. It is the longitudinal cross-sectional view which showed the principal part of the iron sensor 1 for colorectal cancer detection. It is a cross-sectional view of the iron sensor 1 for colorectal cancer detection. It is a longitudinal cross-sectional view of the iron sensor 1 for colorectal cancer detection. It is the longitudinal cross-sectional view which showed the principal part of the iron sensor 11 for colorectal cancer detection. It is a cross-sectional view of the iron sensor 11 for colorectal cancer detection. It is a longitudinal cross-sectional view of the iron sensor 11 for colorectal cancer detection. FIG. 3A is a perspective view of the endoscope 200. FIG. FIG. 2B is a cross-sectional view of the distal end portion 201 of the endoscope 200. FIG. 1 is a perspective view of an endoscope 300. FIG. 3 is a perspective view of an endoscope capsule 400. FIG. It is the photograph of the iron ion selection electrode and reference electrode which were produced in the Example. It is a graph which shows the calibration plot which showed the relationship between an iron ion concentration (horizontal axis) and a potential difference (vertical axis). (A) shows the measurement result of the sample which added the iron ion to 0.1M KCl, (b) shows the measurement result of the sample which added the iron ion to the digestive tract washing | cleaning liquid. It is an iron ion density | concentration measurement result in the digestive tract washing | cleaning liquid extract | collected from the various patients in an Example.

[Colonoscopy]
In describing the endoscope of the present invention, first, a colonoscopy method using the endoscope of the present invention will be described. The colonoscopy method using the endoscope of the present invention includes a step of analyzing a digestive tract washing liquid derived from a subject who is a patient.

Examples of the gastrointestinal lavage fluid derived from the subject include a solution obtained by oral administration of the gastrointestinal lavage fluid and absorption absorption by inserting the endoscope of the present invention through the rectum, or a gastrointestinal lavage fluid accumulated in the body cavity of the subject. Examples of the digestive tract cleaning solution include a commercially available cleaning solution for colonoscopy. As a method of collecting the subject-derived gastrointestinal lavage fluid, for example, on the day before colonoscopy, a person who undergoes colorectal cancer screening drinks 2 L of colonoscopy cleaning solution, and the sample is collected on the day of the examination. Is mentioned.
In the colonoscopy using the endoscope of the present invention, the endoscope only has to be inserted up to the sigmoid colon where the gastrointestinal lavage fluid easily collects, so the physical burden on the person undergoing the examination is reduced.

  The step of analyzing the subject-derived gastrointestinal lavage fluid is preferably a step of measuring the concentration of iron ions in the gastrointestinal lavage fluid. In this process, a conventionally known gastrointestinal lavage fluid derived from a subject is superior in that it does not require special treatment. For example, when PEG (polyethylene glycol) is present in the digestive tract washing liquid, it is necessary to consider a reduction in reaction efficiency in the antigen-antibody reaction using the PEG, but in such a process, PEG is contained in the digestive tract washing liquid. There is no possibility of affecting the measurement system even if exists.

The step of analyzing the subject-derived gastrointestinal lavage fluid is preferably a step of measuring the concentration of iron ions in the gastrointestinal lavage fluid using an ion selective electrode.
In the present invention, an ion selective electrode means an electrode that selectively responds to specific ions. An outline of a measurement system using an ion selective electrode is shown in FIG. The measurement system 70 using an ion selective electrode includes an ion selective electrode 71 that measures the concentration of ions contained in the measurement sample, an external reference electrode 72, and a potentiometer 73.
In the present invention, an ion selective electrode 71 that responds to the cation A ⁺ (iron ion) is used. The ion selective electrode 71 includes an internal reference electrode 71a, an internal solution 71b having a constant activity (a _A ) _{int of} target ions A ⁺ (iron ions), and an ion selective membrane 71c that can transmit only cations. It is configured.
The external reference electrode 72 includes an internal reference electrode 72a, an external electrode internal liquid 72b, and a liquid junction 72c.

As shown in FIG. 1, the ion selective electrode 71 and the external reference electrode 72 are immersed in a target ion (iron ion) activity (a _A ) _sample sample solution 74 (digestive tract washing solution derived from a subject). At this time, assuming that the potential difference (electromotive force) between the two electrodes is E, this is expressed by the following equation (1-1).

Here, E _{ref, int} and E _{ref, ext} are the electrode potentials of the internal reference electrode 71a and the external reference electrode 72, respectively, and E _memb is the internal solution 71b and the sample solution 74 (from the subject via the ion selective membrane 71c). Of the gastrointestinal tract). _Elj is a liquid potential difference generated between the external reference electrode 72 and the sample solution 74 (gastrointestinal washing liquid derived from the subject). In an ideal case where the ion selective membrane 71c transmits only A ⁺ (iron ions), the membrane potential is expressed by the following equation (1-2).

Here, z _A is the number of charges of the target ion, R is the gas constant, T is the absolute temperature, and F is the Faraday constant.
If the electrode potentials of the internal reference electrode 71a and the external reference electrode 72 are constant and the inter-liquid potential difference can be ignored, (a _A ) _int is constant, and therefore the expression (1-1) uses the expression (1-2). The following equation (1-3) is obtained. This is a basic equation of the ion selective electrode and is called a Nernst equation.

Here, E ⁰ is a constant determined by the configuration of the electrode. 2.30 RT / z _A F is called the Nernst coefficient and is the amount of change in electromotive force when the activity of the target ion in the sample solution changes 10 times. It is 29.58 mV for 16 mV and divalent ions. From the measured electromotive force E, the activity of target ions (iron ions) in the sample solution 74 (digestive tract washing liquid derived from the subject) can be determined using the formula (1-3). Since the activity of _{a A} and concentration _{C A} of ions have the relationship of _a A ₌ f A _{C A,} it is possible to determine the concentration _{C A} Knowing activity coefficient _{f A} of ^{A +} ions.
Therefore, in the present invention, it is possible to create a standard curve representing the relationship between the known iron ion concentration and the obtained potential difference, and to measure the iron ion concentration in the gastrointestinal lavage fluid derived from the subject from the standard curve. it can.

The ion selective electrode 71 includes an internal reference electrode 71a, an internal solution 71b, and an ion selective membrane 71c.
Examples of the internal reference electrode 71a include metal / metal halide electrodes, and silver / silver chloride wires are preferable. Examples of the internal solution 71b include a mixed solution of a metal salt aqueous solution such as a potassium chloride aqueous solution and a copper chloride aqueous solution, a potassium chloride aqueous solution, and another metal salt aqueous solution, and a mixed solution of iron nitrate and potassium chloride is preferable.
The ion selective membrane 71c is not particularly limited, and examples thereof include those using a known polymer such as polyvinyl chloride, silicon rubber, polyvinylidene chloride, polyurethane, photoresist, and lacquer as the membrane material. From the viewpoint of realizing high ion selectivity, a liquid membrane formed by mixing a membrane with a plasticizer and dissolving in a solvent is preferable. To such a liquid film, a salt such as potassium tetrakis [3,5-bis (trifluoromethyl) phenyl] borate is added in order to prevent the incorporation of ions (counter ions) other than the target ion into the film. May be.

  The external reference electrode 72 includes an internal reference electrode 72a, an external electrode internal liquid 72b, and a liquid junction 72c. The internal reference electrode 72a includes a metal / metal halide electrode, and a silver / silver chloride wire is preferable. Examples of the external electrode internal solution 72b include aqueous metal salt solutions such as an aqueous potassium chloride solution and an aqueous copper chloride solution, and an aqueous potassium chloride solution is preferred. The potassium chloride aqueous solution may be gelled. When the potassium chloride aqueous solution is gelled, the pressure resistance of the reference electrode can be improved.

  A potential difference between the two electrodes is measured by immersing the ion selective electrode having the ion selective membrane as described above in a sample solution (gastrointestinal lavage fluid derived from a subject) together with an external reference electrode according to a conventionally known method. From the potential difference, the ion concentration in the sample solution (digestive tract washing liquid derived from the subject) is calculated.

[Iron sensor for colorectal cancer detection]
≪First embodiment≫
The endoscope of the present invention includes an iron sensor that analyzes the above-described subject-derived gastrointestinal lavage fluid. Below, the preferable form of the iron sensor for colorectal cancer detection is demonstrated.

FIG. 2 is a longitudinal sectional view showing the main part of the iron sensor 1 for detecting colorectal cancer of the present embodiment. As shown in the figure, the iron cancer sensor 1 for colorectal cancer detection according to the present embodiment includes an ion selective electrode 30 and an external reference electrode 20 formed in a cylindrical shape. Lead electrodes 3 are connected to these electrodes, respectively, and these lead wires 3 are connected to an ion concentration measuring device main body (not shown) having a potentiometer.
When the ion-selective electrode 30 and the external reference electrode 20 are immersed or brought into contact with a digestive tract cleaning solution derived from a subject whose iron ion concentration is to be determined, the difference in iron ion concentration between the internal solution and the digestive tract cleaning solution is determined. The electromotive force is generated according to the voltage, and the electromotive force appears as a potential difference between the ion selective electrode 30 and the external reference electrode 20. An unillustrated ion concentration measuring device main body displays the iron ion concentration of the digestive tract washing liquid derived from the subject using the potential difference as a parameter.

FIG. 3 is a cross-sectional view of the first embodiment of the iron sensor for detecting colorectal cancer, and is a cross-sectional view taken along the line AA of FIG. FIG. 4 is a longitudinal sectional view of a first embodiment of an iron sensor for detecting colorectal cancer.
As shown in FIGS. 3 and 4, the colorectal cancer detection iron sensor 1 of the present embodiment is arranged in a cylindrical shape with the outer cylinder 10 and the outer cylinder 10 being spaced apart from each other. Ion-selective electrode 30 and external reference electrode 20, cured body 40 of the electrode fixing composition filled between these electrodes and outer cylinder 10, ion-selective electrode 30 and external reference electrode 20 An electrolyte crystal 60 fixed to the side end face 50 so as to cover the end portions 22 and 32 of the electrodes, the electrodes 20 and 30, a cured body 40 of the electrode fixing composition, and one end of the electrolyte crystal body 60. And a microporous film 80 covering the outer peripheral region.

Examples of the ion selective electrode 30 and the external reference electrode 20 include those described above.
The outer cylinder 10 is preferably made of a conventionally known flexible resin such as nylon, polyurethane, polyester, polyethylene, polyvinyl chloride, or polycarbonate.
As the cured body 40 of the electrode fixing composition, from the viewpoint that it does not swell even if immersed in or brought into contact with the digestive tract cleaning solution, a conventionally known (meth) acrylic acid monomer and a polymerization initiator are contained. A cured product of the composition is preferred.
The electrolyte crystal 60 is preferably a potassium chloride crystal.
The microporous membrane 80 is not particularly limited as long as it has iron ion permeability, and is preferably formed from the same material as that constituting the outer cylindrical body 10.

<< Second Embodiment >>
FIG. 5 is a longitudinal sectional view showing the main part of the iron sensor 11 for colorectal cancer detection of the present embodiment. As shown in the drawing, in the colon cancer detecting iron sensor 11 of the present embodiment, the external reference electrode 120 is surrounded so as to cover the side surface of the ion selective electrode 130, and these are integrally formed in a cylindrical shape. (See FIG. 6). Lead wires 3 are connected to the ion selective electrode 130 and the external reference electrode 120, respectively, and these lead wires 3 are connected to an ion concentration measuring device main body (not shown) having a potentiometer. Further, the ion selective membrane 130a of the ion selective electrode 130 protrudes from the bottom surface including the liquid junction 120a of the external reference electrode 120 so that the ion selective membrane 130a and the liquid junction 120a can come into contact with the digestive tract cleaning liquid. Is formed.

FIG. 6 is a cross-sectional view of the second embodiment of the iron sensor for detecting colorectal cancer, and is a cross-sectional view taken along the line BB in FIG. FIG. 7 is a longitudinal sectional view of a second embodiment of the iron sensor for detecting colorectal cancer.
The structure of the colorectal cancer detection iron sensor 11 shown in FIGS. 6 and 7 is the same as that of the colorectal cancer detection iron sensor 1 except for the ion-selective electrode 130 and the external reference electrode 120, and thus the description thereof is omitted. To do.

[Endoscope]
≪First embodiment≫
The endoscope of the present invention includes an iron sensor that analyzes the above-described subject-derived gastrointestinal lavage fluid. Below, the preferable form of the endoscope of this invention is demonstrated.

The endoscope 200 according to the present embodiment is a device that takes an image of a subject inside the subject by introducing the insertion unit 202 into a body cavity inside the subject to be observed.
As shown in FIG. 8A, the endoscope 200 is configured to bend a tubular insertion portion 202 having a long and flexible shape and a bending portion 203 provided on the distal end side of the insertion portion 202. An operation unit 204 for connecting, a connector unit 207 connected to a monitor unit (not shown) for displaying a captured image of the body cavity, and a universal cord unit 206 connecting the connector unit 207 and the operation unit 204.
FIG. 8B is a cross-sectional view of the distal end portion 201 of the insertion portion 202 in FIG. As shown in FIG. 8B, the endoscope 200 according to the present embodiment includes an iron sensor 205 for detecting colorectal cancer at the distal end portion 201 introduced into the observation target. The preferred embodiment of the iron sensor for detecting colorectal cancer is as described above, and includes an ion-selective electrode. The iron cancer sensor for colorectal cancer detection is connected to a cable from the distal end portion 201 to the external ion concentration measuring device main body (not shown), and the cable is inserted in the insertion portion 202, the operation portion 204, the universal cord portion 206, and the connector portion 207. Is inserted.

The endoscope 200 of the present embodiment can analyze the digestive tract washing liquid in the sigmoid colon by using an iron sensor 205 for colorectal cancer detection attached to the distal end portion 201. According to this embodiment, since an endoscope should just be inserted to the sigmoid colon where a digestive tract washing | cleaning liquid tends to accumulate, the physical burden of the person who receives a medical examination is reduced.
Furthermore, according to the present embodiment, the endoscopy method that has conventionally relied only on visual information can be supplemented with one that includes iron ion concentration information obtained in real time. That is, according to the present embodiment, an analytical method can be introduced into the physiological function test to add value.

<< Second Embodiment >>
FIG. 9 is a perspective view of the endoscope 300 of the present embodiment. In the present embodiment, the same components as those of the endoscope 200 of the first embodiment are denoted by the same reference numerals, and description thereof is omitted.
As shown in FIG. 9, the endoscope 300 has a liquid absorption tank 306, and an iron sensor 305 for detecting colorectal cancer is provided in the liquid absorption tank 306. The preferred embodiment of the iron sensor for detecting colorectal cancer is as described above, and includes an ion-selective electrode.
The endoscope 300 of the present embodiment is inserted into a suction tank 306 in a sigmoid colon of a subject through a suction conduit (not shown) inserted into the endoscope 300 by a suction source (not shown). Collect gastrointestinal lavage fluid. The suction tank 306 is provided with an iron sensor 305 for detecting colorectal cancer, and measures the concentration of iron ions in the collected digestive tract washing liquid.
According to the present embodiment, in addition to the effects of the first embodiment, it is only necessary to install a colorectal cancer detection iron sensor as an accessory in the conventional liquid absorption tank, so that the endoscope can be manufactured more easily. Can do.

≪Third embodiment≫
FIG. 10 is a perspective view of the endoscope 400 of the present embodiment. The endoscope 400 is a capsule endoscope, and is entirely introduced into a body cavity inside a subject to be observed, and images a subject inside the subject.
As shown in FIG. 10, the endoscope 400 includes a reduced colorectal cancer detection iron sensor 405. The preferred embodiment of the iron sensor for detecting colorectal cancer is as described above, and includes an ion-selective electrode.
The endoscope 400 is generally formed of a plastic material, and includes an iron sensor 405 for detecting colorectal cancer so as to be flush with the surface thereof. Although FIG. 10 shows one colon cancer detection iron sensor 405, the endoscope 400 may include a plurality of colon cancer detection iron sensors 405. Further, the endoscope capsule 400 may include an iron sensor 405 for detecting colorectal cancer so as to partially protrude from the surface thereof.

The endoscope 400 includes an imaging unit 401 and a power supply unit, a control unit, an illumination unit, a wireless unit, and the like (not shown) disposed in a capsule casing 416. The capsule casing 416 includes a hemispherical dome-shaped tip cover casing 416a and a cylindrical trunk casing 416b.
The colorectal cancer detection iron sensor 405 includes a miniaturized ion concentration measuring device main body. When the colorectal cancer detection iron sensor 405 comes into contact with the digestive tract washing liquid in the body cavity, the potential difference between the ion selective electrode and the external reference electrode is measured in the endoscope 400. The colorectal cancer detection iron sensor 405 and the imaging unit 401 are connected to a wireless unit (not shown) that performs wireless communication with the outside, and the potential difference and the imaging information in the body cavity are not shown inside the body outside the body through the wireless unit. Transmitted to the endoscope unit, the endoscope unit displays and records the captured image and iron ion concentration. In the recording, recording is performed by adding time information to each image and potential difference information. As a result, when the data is analyzed afterwards, it is possible to determine which image is at the time when the potential difference data fluctuates. In addition, by providing the endoscope 400 with a storage unit, the data may be stored in its own storage unit instead of being transmitted as needed. Even at the time of recording in the storage unit, recording is performed by adding time information to each image and potential difference information. Further, the potential difference information may be monitored by the endoscope 400 itself, and control may be performed to increase the imaging frequency when this exceeds a predetermined threshold (or when it is determined to be an upward trend). (Information obtained from the colorectal cancer detection iron sensor 405 is discriminated by the control unit, and when the predetermined threshold is exceeded or the value tends to increase, the imaging unit 401 is controlled to increase the imaging frequency.) . Thereby, it is possible to perform imaging in a concentrated manner in the vicinity of a portion suspected of a lesion site.

The conventional capsule endoscope continues to capture about 72,000 images while moving in the body cavity for about 10 hours. The endoscopic practitioner must confirm all these captured images.
According to the present embodiment, when the endoscope 400 moves in the body cavity, information on the iron ion concentration can be obtained in addition to the imaging information, so that the lesion site can be easily recognized in real time.

  EXAMPLES Hereinafter, although an Example demonstrates this invention, this invention is not limited to a following example.

(1) Production of iron ion selective electrode and reference electrode An internal reference electrode of the iron ion selective electrode and the external reference electrode was produced as follows.
First, a silver / silver chloride ink for reference electrode (manufactured by BAS) was applied to a silver wire (diameter 500 μm, length 5 cm, manufactured by Niraco). Then, the internal reference electrode which consists of a silver / silver chloride wire was obtained by air-drying at room temperature.

Next, an ion selective membrane was produced by the following procedure.
5,10,15,20-Tetrakis (pentafluorophenil) porphyrin (made by ALDRICH), Benzyl acetate (made by ALDRICH), Oleic acid (made by SIGMA-ALDRICH), Poly (vinyl chloride) (made by Fluka%, 5.0 each) The mixture was mixed at 55.0 wt%, 10.0 wt%, 30.0 wt%, and an appropriate amount of Tetrahhydrofuran (manufactured by Wako Pure Chemical Industries, Ltd.) was added and dissolved. A small amount of this solution was applied to one hole of a PVC tube (outer diameter 2 mm, inner diameter 1 mm, length 3 cm, manufactured by Sansho) and allowed to dry at room temperature for 24 hours.

This PVC _{tubing, 1mM Fe (NO 3) 3} · 9H 2 O ( Wako Pure Chemical Industries, Ltd.) and containing 0.1 M KCl solution was injected as an internal electrolyte solution, internal reference electrode prepared as described above Inserted. Finally, silicone rubber for sealing (manufactured by Shin-Etsu Silicone) was applied to the other hole of the PVC tube and dried to obtain an iron ion selective electrode shown in FIG.

  Moreover, in order to produce an external reference electrode, a solution obtained by mixing PVA-SbQ (manufactured by Toyo Gosei Co., Ltd.) and a 0.2 MKCl solution at a ratio of 1: 1 was applied to one hole of a PVC tube. Furthermore, the electrolyte gel was produced by irradiating ultraviolet rays for 5 minutes. Next, a 0.1 M KCl solution was injected as an internal electrolyte, and after inserting the above-mentioned internal reference electrode, the other hole was sealed. Thus, the external reference electrode shown in FIG. 11 was obtained.

(2) Creation of calibration plot First, the prepared iron ion selective electrode was immersed in a 5 mM Fe (NO ₃ ) ₃ solution for 24 hours for conditioning. Thereafter, it was rinsed with pure water to wash the outside of the electrode.

As sample solutions, a 0.1 M KCl solution containing different concentrations of Fe (NO ₃ ) ₃ and a digestive tract washing solution were prepared. A 10 mL sample solution was put into a 20 mL beaker, and the iron ion selective electrode and the external reference electrode of FIG. 11 were immersed therein.

  In addition, an electrochemical measurement device (AUTLAB EN 55022, manufactured by Eco Chemie) was used for potential difference measurement. An iron ion selective electrode and an external reference electrode were electrically connected to this electrochemical measuring device.

  The potential difference between the iron ion selective electrode and the external reference electrode was monitored and the potential difference after the potential stabilized was plotted against the common logarithm of iron ion concentration. Five independent measurements were performed on each sample.

FIG. 12A shows a calibration plot representing the relationship between the iron ion concentration and the obtained potential difference. As shown in FIG. 12A, a clear linear relationship was observed between the iron ion concentration and the potential difference.
On the other hand, there was no significant difference in potential difference and slope between the sample obtained by adding iron ions to 0.1M KCl and the sample obtained by adding iron ions to the digestive tract washing solution. Therefore, when the digestive tract washing solution was used, a linear relationship could be obtained between 100 pM and 1 mM (see FIG. 12B). This is considered to be sensitive enough to measure iron ions in the gastrointestinal lavage fluid collected from patients.

(3) Measurement of Iron Ion Concentration in Gastrointestinal Lavage Fluid Collected from Patient Iron ion concentration was measured using a gastrointestinal lavage fluid collected from 14 patients with various diseases as a sample. Similarly to the above, the potential difference between the iron ion selective electrode immersed in the sample and the external reference electrode was measured, and the iron ion concentration was determined using the above calibration plot. Three independent measurements were performed on each sample.

  FIG. 13 shows the measurement results of 14 samples of iron ions. Further, Table 1 shows the diagnostic results of each patient and the measured iron ion concentration. As a result, the iron ion concentration in the gastrointestinal cleaning agent collected from patients who had no findings was low. On the other hand, the iron ion concentration in the gastrointestinal lavage fluid collected from patients with lesions such as polyps was higher than that, and the sample collected from patients with advanced colorectal cancer showed the highest iron ion concentration. These results were thought to be due to iron ions being mixed into the digestive tract washing solution due to bleeding from the lesion. It was suggested that there was a correlation between the size of colorectal lesions and iron ion concentration.

  In addition, it confirmed that the result of the iron ion density | concentration measured using the produced iron ion selective electrode respond | corresponded with the result measured using the commercially available iron ion measuring kit (product made from Funakoshi).

  From the above results, it is clear that according to the endoscope of the present invention, quantitative information based on iron ion concentration measurement can be obtained in real time in addition to qualitative visual information.

  DESCRIPTION OF SYMBOLS 1,11,205,405 ... Iron sensor for colorectal cancer detection, 10 ... Outer cylinder, 20, 120 ... External reference electrode, 20a, 72c, 120a ... Liquid junction part, 22, 32 ... End part, 30, 71 , 130 ... ion selective electrode, 30a, 71c, 130a ... ion selective membrane, 40 ... cured product of electrode fixing composition, 50 ... end face, 60 ... electrolyte crystal, 70 ... measurement system, 71a, 72a ... internal reference Electrode, 71b ... internal solution, 72 ... external reference electrode, 72b ... external electrode internal solution, 73 ... potentiometer, 74 ... sample solution, 80 ... microporous membrane, 200,300,400 ... endoscope, 201 ... tip portion , 202 ... Insertion section, 203 ... Bending section, 204 ... Operation section, 206 ... Universal cord section, 207 ... Connector section, 306 ... Suction tank, 401 ... Imaging section, 416 ... Capsule type casing, 416a ... Over housing, 416b ... body casing.

Claims (5)

At least a portion is introduced into a body cavity of a subject, an endoscope for imaging the interior of objects of the subject, the iron for measuring the concentration of iron ions in the gastrointestinal tract in the cleaning liquid from said subject in real time An endoscope for detecting colorectal cancer, comprising a sensor . The endoscope for detecting colorectal cancer according to claim 1, wherein the iron sensor includes an ion selective electrode. The endoscope for colorectal cancer detection according to claim 1 or 2, further comprising a liquid absorption tank, wherein the iron sensor is provided in the liquid absorption tank. The endoscope for colorectal cancer detection according to claim 1 or 2, wherein the iron sensor is provided at a tip portion introduced into the observation target. The endoscope for colorectal cancer detection according to claim 1 or 2, which is a capsule type.