JP6118614B2 - Calibration method and calibration apparatus - Google Patents

Description

  The present invention relates to a calibration method, a calibration apparatus, and a calibration reference sample.

  The concavo-convex pattern on the surface of a tablet obtained by solidifying a powder drug manufactured by a pharmaceutical company or the like is unique to all tablets. Each image (authentic tablet image) of many authentic tablets manufactured by a pharmaceutical company, etc. is registered, and the same authenticity as the image of the inspection target (verification target) tablet from among the registered many authentic tablet images By searching the tablet image, it is possible to determine whether or not the tablet to be inspected is authentic.

  Imaging of genuine tablets is typically performed by a pharmaceutical company, while imaging of tablets to be inspected is performed in the distribution process (inspection company and others). For this reason, in general, the photographing environment is not the same when an authentic tablet image is captured and when an inspection target tablet is captured. When images are taken in different environments, even if two images are acquired for the same tablet, for example, the shadows appearing in the images are different, and the same authentic tablet image as the image of the tablet to be inspected is displayed. There is a possibility that the accuracy of the search (collation) is lowered. Even if attention is focused only on imaging of genuine tablets, when authentic tablets are produced on different production lines, the photographing environment may be different for each production line.

  Patent Documents 1 to 5 describe those using a calibration plate or the like for image correction or performance evaluation. Citation 6 describes what controls the light emission amount of the illumination means so as to maximize the contrast between the print color and the background color in the image data of the solid medicine.

Japanese Patent No. 5004297 JP 2009-294465 A Japanese Patent No. 4800479 JP 2012-173045 A JP 2007-73925 A JP 2010-190786 A

  However, it is not considered that the photographic environments in different places are the same in any of the cited documents 1 to 6.

  An object of the present invention is to make it possible to reproduce shooting conditions and illumination conditions at the time of imaging of an object performed earlier, at the time of imaging of an object subsequently performed.

  In the calibration method according to the present invention, the master image data output from the first imaging device is stored in the master image storage means by imaging the reference sample with the first imaging device under illumination of the first illumination device. The reference image data output from the second imaging device by imaging the reference sample under illumination of the second illumination device by the second imaging device and stored in the master image storage means The master image data being compared is compared by the similarity calculation means to calculate the similarity of the reference sample image to the master image, and the second imaging device and the second illuminating device are brought closer to the calculated similarity It is characterized by adjusting.

  The present invention also provides a calibration apparatus suitable for the above-described calibration method. The calibration device according to the present invention is a master image storage means for storing master image data output from the first imaging device by imaging a reference sample with the first imaging device under illumination of the first illumination device. And the reference image data output from the second imaging device by imaging the reference sample under illumination of the second illumination device by the second imaging device, and stored in the master image storage means The image processing apparatus includes a similarity calculation unit that compares the master image data and calculates the similarity of the reference sample image to the master image.

  According to the present invention, a master image representing a reference sample imaged by the first imaging device under illumination of the first illumination device and a reference imaged by the second imaging device under illumination of the second illumination device. The similarity of the reference sample image representing the sample is calculated. The calculated similarity can be used for calibration (adjustment) of the second imaging device and the second illumination device. Preferably, the second imaging device is capable of adjusting photographing conditions (image resolution, shutter speed, aperture value, etc.), and the second lighting device is capable of adjusting illumination conditions (illumination angle, etc.). It is. The similarity between the calculated master image and the reference sample image indicates the imaging condition of the second imaging device and the illumination condition of the second illumination device, the imaging condition of the first imaging device, and the illumination condition of the first illumination device. It is used as a guideline (including matching). The imaging conditions of the first imaging device and the illumination conditions of the first lighting device can be reproduced in the second imaging device and the second lighting device.

  In one embodiment, the first imaging device and the first illumination device are genuine products that are output by imaging a plurality of genuine products under the illumination of the first illumination device by the first imaging device. Provided in an image registration device for registering image data in a storage device, and the second imaging device and the second illumination device are configured to send an inspection product under illumination of the second illumination device by the second imaging device. It is provided in an image collating device that determines whether or not genuine image data that matches inspection product image data that is captured and output exists in the storage device. It is possible to match the photographing condition and the illumination condition at the time of photographing the inspection product in the image collating device with the photographing condition and the lighting condition at the time of photographing the genuine product in the image registration device.

  In another embodiment, the first imaging device and the first lighting device pick up and output a plurality of first authentic products under the illumination of the first lighting device by the first imaging device. Provided in the first image registration device for registering the first genuine product image data to the first storage device, and the second imaging device and the second illumination device are provided by the second imaging device. Provided in a second image registration device for registering in the second storage device second genuine product image data output by imaging a plurality of second genuine products under illumination of the second illumination device. Yes. For example, when a first genuine product and a second genuine product are photographed in different production lines, the photographing conditions of the first image registration device and the second image registration device installed in each of the production lines, and Lighting conditions can be adjusted.

  Preferably, the illumination condition includes an illumination angle with respect to the reference sample, and the second illumination device is capable of on / off control about the optical axis of the second imaging device that images the reference sample. A plurality of light source groups are arranged at different angles for illuminating the reference sample. Since the reference sample can be illuminated at various illumination angles, the illumination condition of the second illumination device can be matched to the illumination condition of the first illumination device.

  Preferably, the photographing condition includes at least one of image resolution, shutter speed and aperture value of the imaging device, and the second imaging device has at least one of image resolution, shutter speed and aperture value. One can be adjusted. At least part of the imaging conditions of the second imaging device can be matched with the imaging conditions of the first imaging device.

  In one embodiment, the reference sample has a plurality of fine protrusions formed on the surface thereof. By using a reference sample having fine protrusions imitating the irregularities of the tablet surface formed on the surface, it is possible to adjust photographing conditions and illumination conditions suitable for authenticity determination of the tablet. The present invention includes the above reference sample, that is, an imaging device and an illumination device, and illumination by the illumination device that is used to match the photographing conditions and the illumination conditions with each other for at least two image imaging devices installed at different locations. A calibration reference sample imaged by the imaging device below is also provided.

  In one embodiment, the reference sample has a curved surface. When the tablet surface has a curved surface, use a reference sample that simulates the curved surface of the tablet surface to adjust the shooting conditions and illumination conditions suitable for authenticity determination of tablets with a curved surface. Can do.

  In one embodiment, a reference sample in which a plurality of fine protrusions are randomly arranged on the surface is used. In another embodiment, a reference sample in which a plurality of fine protrusions are regularly arranged on the surface is used.

  Each of the plurality of fine convex portions has a size (diameter, width) of 10 μm to 1000 μm, preferably 30 μm to 500 μm, more preferably 40 μm to 200 μm. In another embodiment, each of the plurality of fine protrusions has a height of 5 μm to 500 μm, preferably 15 μm to 250 μm, more preferably 20 μm to 100 μm. The reference sample can resemble an authentic tablet or a test tablet.

It is a block diagram which shows the whole structure of an authenticity determination system. Indicates registration data. It is a perspective view of an illuminating device. It is sectional drawing of an illuminating device. (A) is a front view of a reference sample, and (B) is a cross-sectional view taken along line VB-VB in (A). The front view of another reference sample is shown. The front view of another reference sample is shown. The front view of another reference sample is shown. (A) is a front view of another reference sample, and (B) is a sectional view taken along line IXB-IXB in (A). The front view of another reference sample is shown. The front view of another reference sample is shown. The front view of another reference sample is shown. A side view of another reference sample is shown. It is a flowchart which shows the flow of the calibration process in an image collation apparatus. It is a flowchart which shows the other example of the calibration process in an image collation apparatus.

  FIG. 1 is a block diagram showing the overall configuration of an authenticity determination system (inspection system).

  In the authenticity determination system, a plurality of genuine tablets 5T1, 5T2, 5T3,... Are inspected into a number of authentic tablet images created by imaging with the imaging device 2 under illumination by the illumination device 3. This is a system for determining whether or not there is the same (or considered to be the same) test tablet image created by imaging a tablet with the imaging device 6 under illumination by the illumination device 7. If the same authentic tablet image as the test tablet image is present in a number of pre-registered authentic tablet images, it is determined that the test tablet used to capture the test tablet image is an authentic tablet. On the other hand, if the same authentic tablet image as the test tablet image does not exist in many authentic tablet images, the test tablet used to capture the test tablet image may not be an authentic tablet (a counterfeit tablet). Determined.

  The authentication system is the same as the registration stage in which each of the authentic tablets 5T1, 5T2, 5T3,... Is imaged to create and register an authentic tablet image, and the test tablet is imaged to create the test tablet image. And a determination stage for determining whether or not the genuine tablet image is included in a number of authentic tablet images. In FIG. 1, the upper part shows an image registration apparatus used in the registration stage, and the lower part shows an image collation apparatus used in the determination stage. In general, the image registration device and the image collation device are installed in different places.

  Referring to the upper part of FIG. 1, the image registration device includes a registration device 1, an imaging device 2, an illumination device 3, and a storage device 4. The registration apparatus 1 is a computer system including a CPU, a memory, a hard disk, and the like. The registration apparatus program is installed on the hard disk and executed, so that the computer system functions as the registration apparatus 1.

  The imaging device 2 includes an image sensor (CCD, CMOS, etc.) that images a reference sample S, which will be described later, and genuine tablets 5T1, 5T2, 5T3,. Output data. Image data representing the reference sample S output from the imaging device 2 and image data representing the authentic tablets 5T1, 5T2, 5T3,... Are input to the registration device 1. Authentic tablets 5T1, 5T2, 5T3... Are the same kind of tablets and are separate tablets.

  FIG. 2 shows registration data 4 </ b> A created by the registration device 1 and stored in the storage device 4.

  The registration data 4A stored in the storage device 4 includes tablet type data, tablet ID, tablet image data, and master image data.

  A pharmaceutical company produces many tablets of the same type (genuine tablets). The tablet type data represents the type of tablet. On the other hand, the tablet ID is an ID given to each individual tablet, and a separate ID is given to each of a number of tablets of the same type. Each tablet image data of each individual tablet specified by the tablet ID is registered in the registration data 4A in association with the tablet ID.

  The master image data is image data representing the surface of the reference sample S described above, and is registered in the registration data 4A for each tablet type. In general, after obtaining a master image by photographing the reference sample S, the process proceeds to photographing genuine tablets 5T1, 5T2, 5T3,.

  Returning to FIG. 1, the image collation apparatus (authentication determination apparatus) shown in the lower stage includes a collation apparatus 5, an imaging apparatus 6, and a storage apparatus 4. Whether the inspection tablet brought in is a genuine tablet or not a genuine tablet (whether it is a counterfeit tablet) is collated and determined by the image collation device using the registration data 4A stored in the storage device 4 described above. .

  Similar to the registration device 1 described above, the verification device 5 is a computer system including a CPU, a memory, a hard disk, etc., and the computer system performs verification by executing a program that causes the computer system to function as the verification device 5 It functions as the device 5. In this embodiment, the storage device 4 included in the image collating device is shown as being the same as the storage device 4 included in the image registration device described above. For example, by connecting the storage device 4 of the image registration device to the verification device 5 via a network (such as the Internet), the storage device 4 can be included in the image verification device. However, the registration data 4A (FIG. 2) stored in the storage device 4 may be downloaded (copied) to another storage device connected to the verification device 5 and stored.

  Prior to photographing the test tablet, the imaging device 6 captures the same reference sample S as the reference sample S used in the above-described image registration device under illumination by the illumination device 7. In the following description, an image obtained by photographing the reference sample S in the image matching device is referred to as a “reference sample image”, and a “master image” obtained by photographing the reference sample S in the image registration device described above. To distinguish. As will be described later, an attempt is made to acquire the same reference sample image as the master image based on the reference sample image created by the image collation device and the master image created by the image registration device. That is, the adjustment of the shooting conditions (image resolution, shutter speed, aperture value, etc.) of the image pickup device 6 of the image collating device and the adjustment of the illumination conditions (illumination angle, etc.) of the lighting device 7 are repeated, whereby the reference sample S The imaging conditions of the imaging device 6 of the image collating device and the illumination conditions of the illuminating device 7 at the time of imaging are matched with the imaging conditions of the imaging device 2 of the image registration device and the illumination conditions of the illuminating device 3 at the time of imaging the reference sample S. Is calibrated (adjusted).

  FIG. 3 is a perspective view showing the positional relationship between the imaging device 6 and the illumination device 7 provided in the image collating device, the reference sample S, and the inspection table 13 on which the reference sample S is placed. FIG. 4 shows an enlarged cross-sectional view of the lighting device 7. In FIG. 4, the imaging device 6 is not shown.

  The imaging device 6 and the illumination device 7 are disposed above the inspection table 13 on which the reference sample S is placed. The illuminating device 7 includes a cover 21 having a hemispherical shape, and a circular camera hole 26 is formed at the apex portion thereof. Inside the cover 21 is attached a support 27 for supporting a large number of semiconductor light emitting element (hereinafter referred to as LED) groups 22A, 22B, 23A, 23B, 24A, 24B. The support 27 is also hemispherical, and a circular camera hole 28 is formed at the apex thereof.

  The imaging device 6 is fixedly provided above the cover 21, and its camera part (lens part) is viewed downward from the camera hole 26 of the cover 21 and the camera hole 28 of the support 27, and the reference sample S is imaged. Imaging data (image data) is taken from the imaging device 6 into the verification device 5.

  The LED groups 22A to 24B are arranged in three stages concentrically around the optical axis of the imaging device 6. The LED groups 22A and 22B are responsible for the illumination from the upper stage, the LED groups 23A and 23B are responsible for the illumination from the middle stage, and the LED groups 24A and 24B are responsible for the illumination from the lower stage. Can be irradiated from different irradiation angles.

  5A is a plan view of the reference sample S, and FIG. 5B is a cross-sectional view of the reference sample S along the line VB-VB in FIG. 5A.

  In the reference sample S, a large number of fine protrusions 11 are regularly arranged in the row direction and the column direction on the surface of the flat base portion, and when viewed from a plane (FIG. 5A), each protrusion 11 Appears circular, and adjacent convex portions 11 are in contact with each other. The diameter of each circular convex part 11 visually recognized from the plane is about 10 μm to 1000 μm, and the height (FIG. 5B) is about 5 μm to 500 μm. When viewed from the cross section, each convex portion 11 appears to be semicircular. Each convex portion 11 is formed by cutting or etching. Since the concave portions are naturally formed between the adjacent convex portions 11, it can also be expressed that the concave and convex portions are formed on the surface of the reference sample S.

  A large number of fine convex portions 11 formed on the surface of the reference sample S imitate the surface of the authentic tablets 5T1, 5T2, 5T3,... Captured by the image registration device of the authenticity determination system described above. However, since it is not easy to faithfully imitate the surfaces of the authentic tablets 5T1, 5T2, 5T3,..., Surface irregularities having similar characteristics are artificially formed. The size of the protrusion 11 may be larger than the unevenness of the surface of the authentic tablets 5T1, 5T2, 5T3,.

  Shadows appear on the surface of the reference sample S due to light incident on the surface of the reference sample S on which a large number of fine protrusions 11 are formed. This shadow also appears in images (master image and reference sample image) acquired by photographing the reference sample S. By calibrating (adjusting) the imaging device 6 and the illumination device 7 of the image matching device so that the shadows of the master image and the reference sample image are the same, the shooting environment of the image matching device can be captured by the image registration device. Can be adapted to the environment.

  6 to 13 show other examples of the reference sample used for the above-described calibration.

  FIG. 6 shows a front view of the reference sample S1 in which the fine convex portions 11 are not formed adjacent to each other. A gap equivalent to the diameter of the fine convex portion 11 is provided between the fine convex portion 11 and the fine convex portion 11.

  FIG. 7 is the same as the reference sample 5 shown in FIGS. 5A and 5B in that a large number of fine convex portions 11 are formed adjacent to each other, but the fine convex portions are roughly arranged for each row and column. A front view of the reference sample S2 in which each fine convex portion 11 is formed by being displaced by half of the diameter of 11 is shown.

  FIG. 8 is a combination of the patterns shown in FIG. 6 and FIG. 7, and each fine convex portion 11 is formed by being displaced by about half the diameter of the fine convex portion 11 for each row and column, and For even rows, a front view of the reference sample S3 in which a gap equivalent to the diameter of the fine convex portion 11 is provided between the fine convex portion 11 and the fine convex portion 11 is shown.

  The reference sample S4 shown in FIGS. 9A and 9B has a fine convex portion 11 in which a large number of fine convex portions 12 are substantially square when viewed from the front, and the fine convex portions 11 appear to be circular when viewed from the front. Different from the reference sample S of A) and (B). When viewed from a cross-section (see FIG. 9B), each fine convex portion 12 looks almost square. The fine convex portion may have another shape such as a quadrangular pyramid. If it is a fine convex part of a quadrangular pyramid, the cross-sectional shape is a triangle.

  FIG. 10 shows a front view of the reference sample S5 in which the fine convex portions 12 described above are not formed adjacent to each other. A gap equivalent to the width of the fine convex portion 12 is provided between the fine convex portion 12 and the fine convex portion 12.

  FIG. 11 shows a front view of the reference sample S6 in which the fine protrusions 11 described above are irregularly formed. FIG. 12 shows a reference sample S7 in which three kinds of fine convex portions 11a, fine convex portions 11, fine convex portions 11b and fine concave portions 11c having different sizes are irregularly formed.

  The reference sample may be one in which fine convex portions are formed on the surface of the base portion having a curved surface imitating the curved surface of the genuine tablets 5T1, 5T2, 5T3,. FIG. 13 shows a reference sample S8 in which a large number of fine convex portions 11 are formed on the surface of a base portion having a curved surface imitating the curved surfaces of genuine tablets 5T1, 5T2, 5T3,. In order to facilitate the placement on the inspection table 13, the bottom surface of the reference sample S8 (the range that is not imaged by the imaging device 6) is formed flat.

  FIG. 14 is a flowchart showing a flow of calibration (adjustment) of the imaging device 6 and the illumination device 7 in the image collating device.

  As described above, the reference sample S is placed on the inspection table 13. The reference sample S is positioned so that the center of the reference sample S is positioned on the optical axis of the imaging device 6. Under the illumination by the illuminating device 7, the reference sample S (the surface thereof) is photographed by the imaging device 6 (step 21).

  A master image corresponding to the reference sample S is read from the registration data 4A (FIG. 2) stored in the storage device 4, and the read master image and the image of the reference sample S acquired by photographing are obtained. Compared (step 22). In the comparison process, for example, an evaluation value representing the degree of similarity between the master image and the reference sample image is calculated. A difference value or a correlation value can be used as the evaluation value. For example, an SSD (Sum of Squared Difference) or SAD (Sum of Absolute Difference) is used to calculate the difference value, and an NCC (Normalized Cross-Correlation) is used to calculate the correlation value. , ZNCC (Zero-mean Normalized Cross-Correlation) can be used.

  If the evaluation value (similarity) equal to or higher than the predetermined first threshold value is not calculated (NO in step 23), the imaging condition of the imaging device 6 is adjusted by the operator of the image verification device. For example, the image resolution, shutter speed, aperture value, etc. are adjusted (step 24). After adjusting the shooting conditions, the reference sample S is shot again and compared with the master image (evaluation value calculation) (steps 21 to 22).

  When the evaluation value equal to or greater than the first threshold is calculated, the reference sample S is taken again and compared with the master image, and the evaluation values of the master image and the reference sample image are calculated again (step 26). A second threshold value larger than the first threshold value is used to determine whether an evaluation value equal to or higher than the second threshold value has been calculated (step 27). The same algorithm may be used for calculating the evaluation value compared with the first threshold and the evaluation value compared with the second threshold, or different algorithms may be used. .

  If the evaluation value equal to or greater than the second threshold value is not calculated (NO in step 27), the illumination condition of the illumination device 7 is adjusted by the operator of the image collating device (step 28). For example, by turning on or off a large number of LED groups 22A to 24B included in the illumination device 7, illumination of only the upper LEDs 22A and 22B, illumination of only the middle LEDs 23A and 23B, illumination of only the lower LEDs 24A and 24B, etc. Done. After adjustment of the illumination conditions, photographing of the reference sample S and comparison with the master image (calculation of evaluation values) are performed again (steps 25 and 26).

  When the evaluation value equal to or greater than the second threshold value is calculated, the adjustment of the imaging device 6 and the illumination device 7 ends (YES in step 27).

  When the adjustment of the imaging device 6 and the illumination device 7 is completed, the process proceeds to imaging of the tablet to be inspected (verification target). A collation process is performed between the photographed image of the test tablet and a plurality of genuine tablet images stored in the storage device 4 (see FIG. 2). For example, a correlation value representing the degree of similarity between images between the test tablet image and each of a plurality of genuine tablet images stored in the storage device 4 is calculated. When a correlation value equal to or greater than a predetermined threshold is calculated, it is determined that the genuine tablet image is the same as or very similar to the test tablet image, and it is determined that the test tablet is a genuine tablet. When only the correlation value less than the predetermined threshold value is calculated, it is determined that the test tablet is not a genuine tablet (a counterfeit tablet).

  FIG. 15 is a flowchart illustrating another example of calibration (adjustment) processing of the imaging device 6 and the illumination device 7 in the image collating device. The same processes in the flowchart shown in FIG.

  In the flowchart shown in FIG. 15, the adjustment of the imaging device 6 and the adjustment of the illumination device 7 are performed simultaneously (step 29). When the evaluation value representing the degree of similarity between the master image and the reference sample image is equal to or greater than the threshold value, the adjustment of the imaging device 6 and the adjustment of the illumination device 7 are completed (YES in step 23).

  In the above-described embodiment, the imaging condition of the imaging device 6 and the illumination condition of the illumination device 7 included in the image collating device are matched (approached) to the imaging condition of the imaging device 2 and the illumination condition of the illumination device 3 included in the image registration device. ing). Of course, not only between the image registration device and the image collation device, but also, for example, the photographing condition and the illumination condition may be matched (approached) between one image registration device and another image registration device. For example, the genuine tablets 5T1, 5T2, 5T3,... Are manufactured in different places (different production lines). In this case, the reference sample S is photographed by each of the one image registration device and the other image registration device, and according to the evaluation value (similarity) described above, the photographing conditions of the imaging device included in one image registration device and The illumination condition of the illumination device is adjusted so as to match the imaging condition of the imaging device provided in the other image registration device and the illumination condition of the illumination device.

1 Registration Device 2, 6 Imaging Device 3, 7 Illumination Device 4 Storage Device (Master Image Storage Means)
4A Registration data 5 Verification device (similarity calculation means)
11, 11a, 11b, 11c, 12 Fine convex part
22A, 22B, 23A, 23B, 24A, 24B LED group S, S1, S2, S3, S4, S5, S6, S7, S8 Reference sample

Claims (7)

Master image data representing a master image including a shadow output from the first imaging device is obtained by imaging a reference sample having a convex portion on the surface under illumination of the first illumination device by the first imaging device. Store it in the image storage means,
Reference sample image data representing a reference sample image including a shadow output from the second imaging device by imaging the reference sample under illumination of the second illumination device by the second imaging device, and the master image The master image data stored in the storage means is compared by the similarity calculation means to calculate the similarity of the reference sample image to the master image,
Adjusting the imaging condition of the second imaging device and the illumination condition including at least the illumination angle of the second illumination device so that the calculated similarity between the reference sample image and the master image approaches.
Calibration method. The first imaging device and the first lighting device store genuine image data output by imaging a plurality of genuine products under the illumination of the first lighting device by the first imaging device. Provided in the image registration device to be registered in
Authentic product in which the second imaging device and the second illumination device match the inspection product image data output by imaging the inspection product under the illumination of the second illumination device by the second imaging device. Provided in an image collation device for determining whether image data exists in the storage device;
The calibration method according to claim 1. The first image pickup device and the first illumination device are configured to output a plurality of first authentic products under the illumination of the first illumination device by the first image pickup device. Provided in a first image registration device for registering product image data in a first storage device;
The second image pickup device and the second illumination device capture a plurality of second authentic products under the illumination of the second illumination device by the second image pickup device and output the second authentic products. Provided in the second image registration device for registering the product image data in the second storage device,
The calibration method according to claim 1. The second imaging device is capable of adjusting shooting conditions,
The second lighting device is capable of adjusting lighting conditions.
The calibration method according to any one of claims 1 to 3. The illumination condition includes an illumination angle with respect to the reference sample, and the second illumination device is capable of on / off control about the optical axis of the second imaging device that images the reference sample. The groups are arranged at different angles to illuminate the reference sample.
The calibration method according to claim 4. The shooting conditions include at least one of image resolution, shutter speed and aperture value of the imaging device, and the second imaging device sets at least one of image resolution, shutter speed and aperture value. Is adjustable,
The calibration method according to claim 4. Master image data representing a master image including a shadow output from the first imaging device is stored by imaging a reference sample having a convex portion on the surface under illumination of the first illumination device by the first imaging device. Master image storage means for
And the reference sample image data representing the reference sample image comprising a shadow output from the second imaging device by imaging the reference sample under the illumination of the second lighting device by the second imaging device, the master image Similarity calculation means for comparing the master image data stored in the storage means and calculating the similarity of the reference sample image to the master image ; and
The imaging condition of the second imaging device and the illumination condition including at least the illumination angle of the second lighting device are set so that the similarity between the reference sample image calculated by the similarity calculation means and the master image approaches. With adjustment means to adjust,
Calibration device.

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