JP6045164B2 - Composition comprising long-life herb polyphenols and vitamin E and / or vitamin C - Google Patents

Description

  The present invention relates to a composition comprising a long-life herb polyphenol and vitamin E and / or vitamin C.

  Vitamin E is one of the fat-soluble vitamins that inhibits lipid oxidation and as a result prevents cell membranes, proteins, and nucleic acids from being damaged, and it is said that vitamin E deficiency causes neuropathy. As the function of vitamin E, it is generally said that “eliminates active oxygen”, “prevents heart disease, stroke, cancer”, “prevents aging” and the like (Non-patent Document 1).

  Vitamin C is one of the water-soluble vitamins necessary for the maintenance of normal capillaries through collagen synthesis and the antioxidant action, and is consumed by stress and smoking. It is said that. The functions of vitamin C are generally “promotes collagen synthesis”, “has antioxidant activity”, “helps absorb iron and copper”, “suppresses the production of melanin pigment”, “improves immunity” It is said to be “enhanced” (Non-Patent Document 2).

  The long-lived grass belonging to the genus Pleurotus is a perennial plant, and in Japan, it is distributed and inhabited in Honshu, Shikoku, Kyushu, and Okinawa Islands west of Kanto and Ishikawa Prefectures. In particular, in the Okinawa region, it is eaten as a sashimi accessory or with goat soup and is treated as a traditional vegetable.

  In recent years, active research has been conducted on the health effects of ingesting long-life grasses, and it is also known that vitamins and polyphenols are contained a lot (Non-patent Document 3).

“Health food” material database [March 16, 2012 search] National Institute of Nutrition and Health website URL <http://hfnet.nih.go.jp/contents/detail43lite.html> "Health food" material database [searched on March 16, 2012] National Institute of Nutrition and Health website URL <http://hfnet.nih.go.jp/contents/detail45lite.html> Journal of Japan Society for Food Science and Technology Vol. 58 No. 3 105-112 (2011)

  An object of the present invention is to provide a composition that exhibits an excellent antioxidant effect. It is also an object of the present invention to suppress oxidation in the composition.

  As a result of intensive studies to solve the above-mentioned problems, the present inventor has a composition containing vitamin E and / or vitamin C in a specific range with respect to the long-life herb polyphenol as a constituent of the composition. Without counteracting the antioxidant action of certain long-life herb polyphenols, vitamin E, and vitamin C, and also exerts an excellent antioxidant action, each of the long-life herb polyphenols, vitamin E, and vitamin C It has been found that the antioxidant action it has is not just an additive increase, but synergistically improved. It was also found that such a composition is excellent in stability because oxidation in the composition is suppressed.

The present invention has been completed based on such findings, and widely encompasses the inventions described below.
Item 1 A composition comprising 0.001 to 10 parts by weight of vitamin E and / or vitamin C with respect to 1 part by weight of a long-life herb polyphenol.
Item 2. The composition according to Item 1, comprising a long life grass or a long life grass extract.
Item 3. The composition according to Item 1 or 2, which is an oral or external composition.

  The composition of the present invention does not negate the antioxidant action of each of the constituent components, such as long-life herb polyphenol, vitamin E, and vitamin C, and only adds to the antioxidant action of each of the constituent ingredients. However, it exhibits excellent antioxidant action even when it is improved synergistically. Further, the composition of the present invention is excellent in stability because oxidation in the composition is suppressed. Therefore, the composition of the present invention is useful as an oral composition and an external composition.

  The present invention will be described below. Various techniques used for carrying out the present invention can be easily and surely implemented by those skilled in the art based on known literatures and the like, except for the technique that clearly indicates the source.

Composition of the Invention The composition of the present invention contains 0.001 to 10 parts by weight of vitamin E and / or vitamin C with respect to 1 part by weight of long-lived polyphenols. That is, the composition of the present invention contains long-life herb polyphenols and vitamin E and / or vitamin C as constituent components, and includes the following three aspects.

  The first aspect of the composition of the present invention is a composition comprising long-life herb polyphenols and vitamin E as constituents, and a long-life herb polyphenol: vitamin E in a ratio of 1: 0.001 to 10 parts by weight.

  The second aspect of the composition of the present invention is a composition comprising long-life herb polyphenols and vitamin C as constituents, and a long-life herb polyphenol: vitamin C in a ratio of 1: 0.001 to 10 parts by weight.

  According to a third aspect of the composition of the present invention, long-life herb polyphenol, vitamin E, and vitamin C are constituents, and the total amount of long-life herb polyphenol: vitamin E and vitamin C is 1: 0.001 to 10 parts by weight. It is a composition which becomes a ratio.

  The compositions of the first to third aspects of the present invention shown below are long-life herb polyphenols and vitamin E and / or vitamin C in a specific blending amount, and are constituents of the composition. It exhibits a significantly superior antioxidant action without countering the antioxidant action of long-life herb polyphenols, vitamin E, and vitamin C.

(First aspect)
The composition of the first aspect of the present invention is a composition comprising long-lived herb polyphenols and vitamin E as constituents, and a long-lived herb polyphenol: vitamin E in a ratio of 1: 0.001 to 10 parts by weight.

  The long life grass polyphenol contained as a constituent in the composition of the first aspect may be contained as a long life grass extract or a long life grass. That is, the composition of the first aspect also includes a composition containing long life grass or long life grass extract and vitamin E.

The long-life grass polyphenol is a polyphenol derived from long-life grass, and is not particularly limited, and examples thereof include flavonoids such as catechin and isoflavone, phenylpropanoids such as lignin and tannin, and chlorogenic acids.
Of these, the long-life herb polyphenol may be a single one or a combination of two or more.

  The long life grass polyphenol can be obtained by using a long life grass as a raw material, for example, by using a known method as described in Non-Patent Document 1. Specifically, after adding hydrous ethanol to long life grass, heating and extracting, the liquid phase fraction obtained by subjecting the extract to a centrifugal separation step and solid-liquid separation is defined as long life grass polyphenol. Good. The method for obtaining the long life grass polyphenol is not limited to such a method, and other methods may be appropriately selected.

  It should be noted that the heating is usually about 80 ° C., and the extraction time is usually about 30 minutes. Further, the ethanol contained in the water-containing ethanol is usually about 80%. Furthermore, water-containing ethanol may be further added to the solid phase fraction that has been subjected to the centrifugation step and recycled to the extraction step.

  The long life grass usually contains about 0.1 to 5 weight percent of the total amount of polyphenol per 100 weight percent converted to the dry weight of the long life grass.

  The method for measuring the total amount of polyphenols contained in the long life grass is not particularly limited, but a known method as described in Non-Patent Document 1, for example, may be adopted. Specifically, it is the Folin-Ciocalteu method, which is obtained by measuring the absorbance at 660 nm by mixing a phenol reagent and a 10% sodium carbonate reagent with a measurement sample. Note that gallic acid may be used as the standard substance, and may be calculated as an amount equivalent to gallic acid.

  Long-life grass is a perennial plant that belongs to the genus Ornamentaceae and is also referred to as button-bow.

  The long-life grass used as a raw material for the long-life grass polyphenol may be whole grass excluding stems, leaves, and roots.

  Such a long life grass may be a dried product or a pulverized product. The dried product is obtained by subjecting the long-life grass to a known drying process, and the specific process is not particularly limited. The pulverized product is obtained by subjecting the above-mentioned long life grass or a dried product thereof to a known pulverization process, and the specific process is not particularly limited.

  The long life grass that is a constituent of the composition of the first aspect may be the above-mentioned long life grass itself.

  The long-life grass extract that is a constituent of the composition of the first aspect may be obtained by the above-described method for extracting long-life grass polyphenols, but other known plant extraction methods are adopted. It may be obtained. Usually, a long-life herb extract can be obtained by subjecting a plant of long-life grass (whole or part of the plant) to a known extraction method such as a supercritical extraction method. In addition, the obtained extract may be appropriately subjected to a solid-liquid separation step to remove a solid phase fraction, or an appropriately obtained drying step may be used as a long life grass extract.

  Vitamin E that is a constituent of the composition of the first aspect includes tocopherol (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, etc.) and derivatives thereof. Examples of the tocopherol derivative include tocopherol acetate, tocopherol succinate, tocopherol nicotinate and the like. These tocopherols and tocopherol derivatives may be salts that are acceptable in the fields of foods, pharmaceuticals, cosmetics and the like.

  These vitamin E may be used individually by 1 type, or may be used in combination of 2 or more types arbitrarily.

  The content of vitamin E in the composition of the first aspect is 0.001 to 10 parts by weight with respect to 1 part by weight of the long-life herb polyphenol contained in the composition of the first aspect. Preferably, it is about 0.001-5 weight part, More preferably, it is about 0.05-5 weight part.

  In addition, when the long-life grass polyphenol in the composition of the first aspect is contained as a long-life grass, the content of vitamin E is a value converted to a dry weight, and the long-life grass 1 contained in the composition of the first aspect 1 The amount is about 0.00001 to 0.1 parts by weight with respect to parts by weight. The amount is preferably about 0.00001 to 0.05 parts by weight, and more preferably about 0.0005 to 0.05 parts by weight.

  When the long life herb polyphenol in the composition of the first aspect is contained as a long life herb extract, the content of vitamin E is determined by measuring the total amount of polyphenols contained in the long life herb extract, and the long life herb as described above. What is necessary is just to set suitably the quantity converted into content of polyphenol. What is necessary is just to employ | adopt the method described in the above-mentioned nonpatent literature 1, and to measure the content of specific polyphenol.

  Such a composition according to the first aspect of the present invention does not counteract the antioxidant action of long-life herb polyphenols and vitamin E, which are constituents, and the antioxidant action of each of these is additive. In addition to being demonstrated in, it exhibits an excellent effect synergistically.

(Second aspect)
The composition of the second aspect of the present invention is a composition comprising long-life herb polyphenols and vitamin C as constituents, and a long-life herb polyphenol: vitamin C in a ratio of 1: 0.001 to 10 parts by weight.

  The long life grass polyphenol contained in the composition of the second aspect may be contained as a long life grass extract or a long life grass. That is, the composition of the second aspect includes a composition containing long life grass or long life grass extract and vitamin C.

  The long life grass polyphenol, the long life grass extract, and the long life grass are as described in detail in the above (first aspect).

  Vitamin C which is a constituent of the composition of the second aspect includes ascorbic acid (D-ascorbic acid, L-ascorbic acid, DL-ascorbic acid, etc.) and derivatives thereof. Examples of ascorbic acid derivatives include ascorbyl palmitate and ascorbyl phosphate. These ascorbic acid and ascorbic acid derivatives may be salts such as sodium ascorbate that are acceptable in the fields of foods, pharmaceuticals, cosmetics and the like.

  The vitamin C includes erythorbic acid and its derivatives. Examples of erythorbic acid derivatives include palmitic sun erythorbyl and erythorbyl phosphate. These erythorbic acid and erythorbic acid derivatives may be salts such as sodium erythorbate that are acceptable in the fields of foods, pharmaceuticals, cosmetics and the like.

  These may be used alone or in any combination of two or more.

  The content of vitamin C in the composition of the second aspect is 0.001 to 10 parts by weight with respect to 1 part by weight of the long life herb polyphenol contained in the composition of the second aspect. Preferably, it is about 0.01-5 weight part, More preferably, it is about 0.05-1 weight part.

  In addition, when the long-life herb polyphenol in the composition of the second aspect is contained as a long-life herb, the content of vitamin C is a value converted to dry weight, and the long-life herb 1 contained in the composition of the second aspect 1 The amount is about 0.00001 to 0.1 parts by weight with respect to parts by weight. The amount is preferably about 0.0001 to 0.05 parts by weight, and more preferably about 0.0005 to 0.01 parts by weight.

  When the long life herb polyphenol in the composition of the second aspect is contained as a long life herb extract, the content of vitamin C is determined by measuring the total amount of polyphenols contained in the long life herb extract, as described above. What is necessary is just to set suitably the quantity converted into content of polyphenol. What is necessary is just to employ | adopt the method described in the above-mentioned nonpatent literature 1, and to measure the content of specific polyphenol.

  Such a composition according to the second aspect of the present invention does not counteract the antioxidant action of long-life herb polyphenols and vitamin C, which are constituents, and the antioxidant action of each of these is additive. In addition to being demonstrated in, it exhibits an excellent effect synergistically.

(Third aspect)
The composition of the third aspect of the present invention comprises a long-life herb polyphenol, vitamin C, and vitamin E as constituents, and the total amount of the long-life herb polyphenol: vitamin E and vitamin C is 1: 0.002 to 10 parts by weight. It is the composition which becomes.

  The long life grass polyphenol contained as a constituent in the composition of the third aspect may be contained as a long life grass extract or a long life grass. That is, the composition of the third aspect includes a composition containing long life grass or long life grass extract, vitamin E, and vitamin C.

  The long life grass polyphenol, the long life grass extract, and the long life grass are as described in detail in the above (first aspect).

  Vitamin E is as detailed in the above (first aspect), and vitamin C is as detailed in the above (second aspect).

  The content of the total amount of vitamin C and vitamin E in the composition of the third aspect is 0.002 to 10 parts by weight with respect to 1 part by weight of the long life grass polyphenol contained in the composition of the third aspect. Preferably, it is about 0.05-3 weight part, More preferably, it is about 0.1-1 weight part.

  Moreover, when the long life herb polyphenol in the composition of the 3rd aspect is contained as a long life grass, content of the total amount of vitamin E and vitamin C is set to the value of 3rd aspect in the composition of the 3rd aspect as a value converted into dry weight. It is about 0.00002-0.1 weight part with respect to 1 weight part of long life grass contained. The amount is preferably about 0.0005 to 0.03 part by weight, and more preferably about 0.001 to 0.01 part by weight.

  The content of the total amount of vitamin E and vitamin C when the long-life grass polyphenol in the composition of the third aspect is included as the long-life grass extract is the above-mentioned after measuring the total amount of polyphenol contained in the long-life grass extract. What is necessary is just to set suitably the quantity converted into content of such a long life grass polyphenol. What is necessary is just to employ | adopt the method described in the above-mentioned nonpatent literature 1, and to measure the content of specific polyphenol.

  Such a composition according to the third aspect of the present invention does not counteract the antioxidant action of long-life herbaceous polyphenols, vitamin E, and vitamin C, and the antioxidant action of each of them. Is not only additive, but synergistically excellent.

  As described above, the composition of the present invention in which vitamin E and / or vitamin C is blended in a specific range with respect to the long-life herb polyphenol and the long-life herb polyphenol counteracts the antioxidant action of the constituents. In addition, it exhibits an excellent antioxidant effect. Therefore, the composition of the present invention can be particularly preferably used in the field applied to humans such as pharmaceuticals, foods (including oral and parenteral), cosmetics, etc., and should be an oral composition or an external composition. Can do.

  When the composition of the present invention is applied to humans, the amount applied is not particularly limited, but it is usually about 0.01 to 50 mg in terms of the amount of long-life grass polyphenols, more preferably, About 1 to 10 mg.

Oral composition of the present invention The composition of the present invention described above can be an oral composition. That is, the oral composition of the present invention contains long-life herb polyphenols and vitamin E and / or vitamin C as constituent components. Moreover, the long life grass polyphenol contained as a component in the oral composition may be contained as a long life grass extract or a long life grass. That is, the oral composition includes a long life grass or a long life grass extract and an oral composition containing vitamin E and / or vitamin C. Examples of such oral compositions include food compositions and pharmaceutical compositions.

(Food composition)
If the oral composition of the present invention is a food composition, the oxidation reaction in the oral composition can be suppressed, and it can be preserved for a long period of time, so that high quality stability can be maintained. it can. Moreover, it can be expected that an antioxidative action is exerted in vivo by ingesting the oral composition of the present invention. When an antioxidant action is exerted in a living body, it is possible to prevent attacks on cells and nucleic acids in the living body due to the action of active oxygen, and it is expected to prevent aging of cells and tissues. That is, the so-called anti-aging function is expected to be exhibited by ingesting the food composition of the present invention.

  When the oral composition of the present invention is used as a food composition, the above-described composition of the present invention may be used as it is as a food composition, and usually in various food forms together with carriers and additives that are acceptable in the field of food. It may be prepared. The content of the long-lived herb polyphenol and vitamin E and / or vitamin C in the food composition can also be appropriately set according to the composition of the present invention described above.

  The form of the food is not particularly limited, and examples thereof include various foods such as confectionery, breads, and soups.

  In addition to the above-mentioned foods, the food composition of the present invention is a health food (nutrient functional food, food for specified health use, etc.), supplement, and sick for the purpose of exerting an antioxidant effect when ingested. It can also be prepared as a functional food such as food. When preparing as such food, it should be prepared in the form of granules, films, tablets, capsules, tablets (including chewables, etc.), beverages (drinks), etc. Among these, capsules and tablets are preferable from the viewpoint of ease of ingestion, but are not particularly limited thereto.

  The food composition prepared in the above-described form can also be appropriately prepared according to a conventional method using the above-described carrier acceptable in the field of food. Moreover, even when preparing in other forms, conventional methods may be followed, and the production method is not particularly limited as long as it does not impair the effects of the present invention, and is used by those skilled in the art for each application. It is sufficient to follow the method.

  In addition, food for specified health use (including food for specified health use with conditions) can show the function / effect of the food, for example, by displaying that the packaging container has an effect of imparting an antioxidant effect. Food.

  In preparing the above-mentioned foods, functional foods and the like, they can be added together with auxiliary materials and additives usually used.

  Although the effective intake per day of the food composition of the present invention is not particularly limited, the intake may be usually about 0.01 to 50 mg by weight in terms of the amount of long-life grass polyphenol. Such an intake can be taken 1 to several times a day, and an effective amount can be taken efficiently.

(Oral pharmaceutical composition)
If the oral composition of the present invention is an oral pharmaceutical composition, the oxidation reaction in the oral pharmaceutical composition can be suppressed, and high quality stability can be maintained, such as storage over a longer period of time. be able to. Moreover, it can be expected that an antioxidative action is exerted in vivo by oral administration of the oral pharmaceutical composition of the present invention. When the antioxidant action is exerted in the living body, it is possible to prevent an attack on cells or a nucleic acid in the living body by the action of active oxygen, and the treatment or prevention of a disease caused by such an attack. Expected to work as an agent. Specific examples of the disease include, but are not limited to, Alzheimer type dementia, Parkinson's disease, diabetic complications, rheumatoid arthritis, amyotrophic lateral sclerosis, cardiovascular disease, cerebrovascular disease, hypertension cancer and the like. .

  Here, prevention means preventing the onset of the disease, specifically, preventing the onset of such a disease by acting on the onset mechanism of the disease in advance, It can be understood that a function higher than that at the time of normal or remission is acquired, and physiological damage of a lesion caused after the onset of the disease is reduced.

  When the oral composition of the present invention is used as an oral pharmaceutical composition, the composition of the present invention described above may be used as it is as an oral pharmaceutical composition, and various dosage forms are usually used together with carriers and additives that are acceptable in the pharmaceutical field. May be prepared. The content of the long life herb polyphenol and vitamin E and / or vitamin C in the oral pharmaceutical composition can be appropriately set according to the composition of the present invention described above.

  The dosage form of the oral pharmaceutical composition of the present invention is not particularly limited, and examples thereof include powders, tablets, granules, pills, capsules (soft capsules or hard capsules), troches, chewable tablets, and dry syrups. Can be mentioned. Moreover, you may have a formulation form which controlled the release | release property of the medicinal component (for example, immediate release formulation, sustained release formulation, etc.). Also preferred are tablets, granules, pills, and capsules (soft capsules or hard capsules). Formulations having such dosage forms can be prepared according to conventional methods in the art.

  The oral pharmaceutical composition may be formulated with various carriers and additives that are pharmaceutically acceptable for oral administration in order to formulate the oral dosage form described above and to stabilize the oral dosage form (for example, Japan). (See Pharmacopoeia, “Pharmaceutical Additives Encyclopedia” (published by Yakuji Nippo).

  In addition to the above components, as long as the effect of the present invention is not diminished, stabilizers, dispersants, fluidizing agents, buffering agents, wetting agents, thickening agents, preservatives, and the like, which are usually acceptable as additives for pharmaceuticals, Optional components such as a pH adjuster, a solvent, a solubilizing agent and the like can be added as desired.

  In addition to the above, other components such as amino acids, vitamins, and inorganic salts may be included.

  The above-mentioned oral pharmaceutical composition can be prepared and administered as the above-mentioned solid or liquid oral preparation (internal preparation), and the dosage depends on the age, sex, degree of symptoms to be treated, and administration method. However, the daily dose for an adult is usually about 0.01 to 50 mg, preferably about 1 to 10 mg in terms of the amount of long-lived polyphenol contained in the oral pharmaceutical composition. If it is this administration range, it can also administer in 1 to several times a day.

  The oral pharmaceutical composition of the present invention can be used in combination with pharmaceuticals for known diseases in order to provide a better preventive or therapeutic effect.

The composition for external use of this invention The composition of this invention mentioned above can be used as an external composition. That is, the composition for external use of the present invention contains long-life herb polyphenol and vitamin E and / or vitamin C as constituent components. Moreover, the long life grass polyphenol contained as a component in the composition for external use may be contained as a long life grass extract or a long life grass. That is, the composition for external use includes a long life grass or a long life grass extract and a composition for external use containing vitamin E and / or vitamin C.

(External pharmaceutical composition)
If the externally applied composition of the present invention is used as an externally applied pharmaceutical composition, the oxidation reaction in the externally applied pharmaceutical composition can be suppressed, and high quality stability can be maintained, such as being able to be stored for a longer period of time. be able to. Moreover, it can be expected that an antioxidative action is exhibited in vivo when the pharmaceutical composition for external use of the present invention is transdermally or transmucosally administered. When an antioxidant action is exerted in a living body, it is possible to prevent an attack on cells or a nucleic acid in the living body due to the action of active oxygen, and a treatment or prevention of a disease caused by such an attack. Expected to work as an agent. Although it does not specifically limit as a specific disease, For example, atopic skin, atopic dermatitis, psoriasis, ichthyosis, stomatitis, psoriasis etc. are mentioned.

  Here, prevention means preventing the onset of the disease, specifically, preventing the onset of such a disease by acting on the onset mechanism of the disease in advance, It can be understood that a function higher than that at the time of normal or remission is acquired, and physiological damage of a lesion caused after the onset of the disease is reduced.

  When the composition for external use of the present invention is used as a pharmaceutical composition for external use, the composition of the present invention described above may be used as it is as a pharmaceutical composition for external use. Usually, various foods are used together with carriers and additives that are acceptable in the pharmaceutical field. What is necessary is just to prepare in a form. The content of the long-lived herb polyphenol and vitamin E and / or vitamin C in the external pharmaceutical composition can also be appropriately set according to the composition of the present invention described above.

  The dosage form of the external pharmaceutical composition of the present invention is not particularly limited, and examples thereof include liquid preparations such as liquids, emulsions and suspensions; semisolid preparations such as ointments and gels. Formulations having such dosage forms can be prepared according to conventional methods in the art.

  In order to formulate the external pharmaceutical composition into the above-mentioned external dosage form and to stabilize the pharmaceutical composition, various carriers and additives that are pharmaceutically acceptable for external administration can be blended (for example, Japan). (Refer to Pharmacopoeia, “Pharmaceutical Additives Encyclopedia” (published by Yakuji Nippo)).

  In addition to the above components, as long as the effect of the present invention is not diminished, stabilizers, dispersants, fluidizing agents, buffering agents, wetting agents, thickening agents, preservatives, and the like, which are usually acceptable as additives for pharmaceuticals, Optional components such as a pH adjuster, a solvent, a solubilizing agent and the like can be added as desired.

  In addition to the above, other components such as amino acids, vitamins, and inorganic salts may be included.

  The above-mentioned external pharmaceutical composition can be prepared and administered as the above-mentioned preparation, and the dosage depends on the patient's age, sex, degree of symptoms to be treated, and administration method. The daily dose of the long-life herb polyphenol contained in the composition to an adult is usually about 0.01 to 50 mg, preferably about 1 to 10 mg.

(Cosmetic composition)
If the composition for external use of the present invention is a cosmetic composition, the oxidation reaction in the cosmetic composition can be suppressed, and high quality stability can be maintained, such as storage over a longer period of time. be able to. Moreover, it can be expected that the antioxidant composition is exerted in vivo by applying the cosmetic composition of the present invention to skin, hair and the like. When the antioxidant action is exerted in the living body, it is possible to prevent the attack on the cells and the nucleic acid in the living body due to the action of the active oxygen, and the skin and hair tissues and cells caused by such an attack etc. It is expected to prevent aging. In particular, it is expected to have an effect as an anti-aging cosmetic which shows an effect of slowing or improving skin abnormalities such as skin wrinkles, atrophy, skin tissue loss, skin discoloration and the like due to aging. Moreover, since it is also expected to reduce the stress of participating in hair root cells in the scalp, an improvement effect on thinning hair is also expected.

  When the composition of the present invention is used as a cosmetic composition, the above-described composition of the present invention may be used as it is as a cosmetic composition. Usually, various cosmetics are used together with carriers and additives that are acceptable in the cosmetic field. What is necessary is just to prepare in a form. The content of the long-lived herb polyphenol and vitamin E and / or vitamin C in the cosmetic composition can also be appropriately set according to the composition of the present invention described above.

  The shape of the cosmetic composition is not particularly limited, but for example, paste, lotion, mousse, gel, jelly, liquid, emulsion, suspension, cream, ointment, sheet, aerosol And spray form. Further, the form of the cosmetic composition is not limited. For example, makeup cosmetics such as foundation, blusher, and white powder; basic makeup such as lotion, emulsion, cream, lotion, oil, and pack Skin cleansing agents such as facial cleansers, cleansings, body cleansing agents, massage agents, wiping agents, detergents, bathing agents, and the like.

  The present invention is described in further detail below. However, it goes without saying that the present invention is not limited to the following examples.

<Long-life herb polyphenol>
The long-life herb polyphenol used in this example was produced with reference to a known method. Specifically, the method is as follows.

  To 0.1 g of long life grass powder (manufactured by Nippon Lanchester Industry Co., Ltd.), 4 mL of 80% ethanol was added and allowed to stand at 80 ° C. for 30 minutes. Thereafter, it was subjected to a centrifugal separation step for solid-liquid separation, and solid phase residues were removed. These operations were repeated 5 times, and the liquid phase fraction was used as an extract. The obtained extract was concentrated so that the content of polyphenol contained as a main component was about 0.1% by weight. The obtained extract was used as a long-life grass polyphenol in the following experiments. Further, the total amount of the extracted long life grass polyphenol was about 0.01 parts by weight with respect to 1 part by weight of the raw material long life grass powder. The total amount of long-life grass polyphenols was measured using the method described above.

<Measurement 1 of antioxidant activity>
The long-life herb polyphenol obtained by the above-mentioned method and vitamin E (DSM Nutrition Japan Co., Ltd., dry vitamin E 50%) were mixed at the ratio shown in Table 1 below to prepare a test solution for measuring antioxidants.

  The antioxidant solution was measured for the obtained test solution using an antioxidant measurement kit (Niken Zile Co., Ltd., Japan Aging Control Laboratory). The measured values of each test solution are shown in Table 1 as actual measured values.

  From the evaluation values shown in Table 1, when 100 parts by weight of vitamin E is blended with respect to 1 part by weight of the long-life herb polyphenol (Comparative Example 1), the antioxidant effect is significantly reduced compared to the theoretical value. It became clear. It has been clarified that such an amount of vitamin E is usually not used even when it is expected to be obtained even though it is an amount used in the composition. That is, it has been clarified that long-life herb polyphenols, when vitamin E, itself exhibits an antioxidant effect, counteracts the antioxidant activity of each when blended in a specific range of proportions.

  On the other hand, when 0.001 to 10 parts by weight of vitamin E was added to the long-life herb polyphenol, the antioxidant effect as in Comparative Example 1 was not observed. In particular, it was also clarified that a synergistic antioxidant action is exhibited when the amount of vitamin E is 0.001 to 5 parts by weight.

<Measurement of antioxidant activity 2>
The long-life herb polyphenol obtained by the above-mentioned method and vitamin C (DSM Nutrition Japan Co., Ltd. sodium ascorbate) were mixed at the ratio shown in Table 2 to prepare a test solution for antioxidant measurement.

  The antioxidant solution was measured for the obtained test solution using an antioxidant measurement kit (Niken Zile Co., Ltd., Japan Aging Control Laboratory). The measured values of each test solution are shown in Table 2 as measured values.

  From the evaluation values shown in Table 2, when 100 parts by weight of vitamin C is blended with respect to 1 part by weight of the long-life herb polyphenol (Comparative Example 2), the antioxidant effect is significantly reduced compared to the theoretical value. It became clear. It has been clarified that such an amount of vitamin C is not usually obtained even though it is the amount used when blended in a composition, even though it is usually an expected antioxidant action. That is, it has been clarified that long-life herb polyphenols, when vitamin C, itself exhibits an antioxidant effect, counteracts the antioxidant activity of each when blended in a specific range.

  On the other hand, when 0.001 to 10 parts by weight of vitamin C was blended with respect to the long-life herb polyphenol, a decrease in the antioxidant effect as in Comparative Example 1 was not observed.

<Prescription Examples 1-20>
Tablets were prepared as usual according to the formulations shown in Tables 3 and 4. All were excellent in the antioxidant effect like the Example.

<Prescription Examples 21 to 40>
Capsules were prepared according to standard methods according to the formulations shown in Tables 5 and 6. All were excellent in the antioxidant effect like the Example.

<Prescription Examples 41 to 60>
According to the formulation shown in Tables 7 and 8, the composition for external use was prepared in a conventional manner. All were excellent in the antioxidant effect like the Example.

Claims (4)

For 1 part by weight of long-life herb polyphenol , 0 . A composition comprising 001 to 5 parts by weight. The composition according to claim 1, further comprising vitamin C, wherein the total amount of vitamin C and vitamin E is 0.002 to 10 parts by weight with respect to 1 part by weight of the long-life herb polyphenol. The composition of Claim 1 or 2 containing a long life grass or a long life grass extract. The composition according to any one of claims 1 to 3, which is an oral or external composition.