JP5963744B2 - Pharmaceutical composition application device - Google Patents

Description

  The present invention applies a pharmaceutical composition in a gap between an inserted body inserted and placed in a living body and a living tissue, and prevents the entry of foreign substances such as bacteria and dirt from the outside into the gap. Regarding devices.

  In general, when an insert is inserted and placed in a living body, a gap may be formed between the insert and a living tissue (for example, the body surface), and microorganisms (for example, bacteria resident in the skin) or If foreign matter such as dirt enters, there is a risk of causing infection or inflammation.

  In order to prevent such infectious diseases and inflammations, a treatment for applying an adhesive film dressing so as to cover the insert inserted in the living body or its peripheral portion from above (see Patent Document 1 below), antibacterial fibers The formed pad (see Patent Document 2 below), or a treatment (see Patent Document 3 below) for covering the insert or its peripheral part with an elastic pad containing a polymer for releasing an antibacterial agent is taken. Yes.

JP-A-9-94299 JP 2008-220633 A Japanese Patent No. 3046623

  The treatment of applying such a dressing agent or pad to the insert or its peripheral part can obtain a certain effect for prevention of infection and inflammation.

  However, since the treatment of covering the insert or its peripheral part with such a dressing agent or pad only covers the gap between the insert and the living tissue from above, bacteria, dirt, etc. that have entered the gap It is difficult to reliably prevent infection and inflammation.

  Also, when sticking the pad, the outer diameter of the insert must be smaller than the inner diameter of the opening established in the pad, and it may be difficult to select the size of the insert or pad opening. There is also a problem that the entire circumference or azimuth of the insert cannot be reliably closed.

  The present invention has been made in order to solve the above-described problems. The gap formed between the insert and the living tissue is reliably closed with the pharmaceutical composition, and foreign matters such as bacteria and dirt enter the gap from the outside. An object of the present invention is to provide a device for applying a pharmaceutical composition that can prevent the risk of infection and significantly reduce the risk of infection and inflammation.

  The drug composition application device of the present invention that achieves the above object is a drug composition application device that applies a drug composition to a gap between an insert inserted into a living body and a living tissue, A housing part that is provided in the insert and contains a drug composition that has antibacterial properties and fluidity with respect to the living tissue; an unsealing part that can open the housing part; and the housing part It is characterized in that the drug composition that flows out along with opening is guided to the gap by flowing along at least a part of the insert.

The present invention provides an insertion body containing a drug composition having antibacterial properties and fluidity with respect to a living tissue in the insert, and the drug composition flowing out when the container is opened is Since it is guided at least partially through the gap between the insert and the living tissue, the insertion portion that is the entrance portion of the gap is simply opened by inserting the insert into the living body. Can be covered with a pharmaceutical composition. In addition, in conventional adhesive film dressings or pads, the finger touches the adhesive part, and the adhesive part is contaminated by bacteria, blood, dirt, etc. attached to the finger. The portion can be covered with a pharmaceutical composition. Therefore, after inserting the insert into the living body, the operator can significantly reduce the risk of foreign substances such as bacteria and dirt entering the gap formed between the insert and the living tissue and causing infection and inflammation. . In addition, it is not necessary to select the size of the outer diameter of the insert or the pad opening as in the conventional case, minimizing the increase in the number of procedures and devices, and speeding up the procedure. Convenience is also greatly improved. In addition, since a guide portion is provided for guiding the flow of the pharmaceutical composition so that the pharmaceutical composition flows down the gap through the insertion body, a smooth flow of the pharmaceutical composition from the accommodating portion to the gap is formed. The pharmaceutical composition can be applied easily and quickly.

  In the invention of claim 2, the housing part is constituted by a bag-like bag capable of enclosing the pharmaceutical composition, and the opening part is constituted by a weak seal part having a weak seal strength provided in at least a part of the bag. Therefore, the pharmaceutical composition can be caused to flow out toward the gap between the insert and the living tissue by the rupture of the weak seal portion. Particularly, since the operator ruptures the weak seal portion of the bag after inserting the insert into the living body, the insertion operation of the insert and the rupture operation of the weak seal portion can be performed independently. It becomes effective when it is set at a desired position after repeating the insertion operation. After inserting and setting the insertion body, a predetermined amount of the pharmaceutical composition can be appropriately applied by one rupture operation, and the convenience of the procedure is improved. Greatly improved.

  The invention of claim 3 divides the inside of the bag into a plurality of storage chambers by partition walls, stores different drug compositions in each storage chamber, and mixes the plurality of drug compositions by rupture operation of the bag. Even pharmaceutical compositions that require different properties such as antibacterial properties and adhesiveness can be set without problems, and the mixed pharmaceutical composition can be used to close the gap between the living tissue and the insertion member. Moreover, it can also apply | coat so that the peripheral part of an insertion part may be covered widely, and the generation | occurrence | production risk of an infection or inflammation can be reduced significantly. In particular, if the inside of one bag is partitioned into a plurality of storage chambers by partition walls, the pharmaceutical composition mixed by a single crushing operation can be applied to the gap or the peripheral portion of the insertion portion.

  In the invention of claim 4, the bag is composed of a plurality of bags each containing different drug compositions, and the drugs having different properties are mixed by the rupture operation of the weak seal portion of each bag. The bag is easy to break and the convenience of the procedure is improved.

  According to a fifth aspect of the present invention, the insert includes an insertion member to be inserted into the living body, and a large diameter portion provided on the proximal end side of the insertion member, and the accommodating portion is provided in the large diameter portion. Therefore, when performing a normal procedure, i.e., a procedure for inserting the insertion member to the vicinity of the large diameter portion, in a state where the insertion member is inserted, the accommodation portion exists in the vicinity of the operated hand. Opening can be performed easily. Further, since the container is opened near the entrance of the gap between the living tissue and the insertion member, the drug composition that has flowed out of the container immediately closes the gap between the living tissue and the insertion member, and is inserted. It is applied so as to cover the peripheral part of the part, and the risk of infection and inflammation can be greatly reduced.

  In the invention of claim 6, since the insert is an indwelling needle having an outer needle as the insertion member and a catheter hub as the large diameter portion, the effect of the previous item is effectively exhibited and a smooth procedure is performed. It can be done easily.

  In the invention of claim 7, since the drug composition is colored, when inserting the insert, the drug composition itself becomes a kind of guide, and the range of the puncture portion of the insert and the sealing condition are visually confirmed. The procedure can be performed smoothly and reliably.

It is a partially broken schematic front view showing a first embodiment of the present invention. It is a schematic perspective view which shows the action state of the embodiment. It is a principal part schematic perspective view which shows 2nd Embodiment of this invention. It is a principal part schematic perspective view which shows the modification of the embodiment. It is a schematic perspective view which shows 3rd Embodiment of this invention. It is a schematic perspective view which shows 4th Embodiment of this invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.
(First embodiment)
FIG. 1 is a partially broken schematic front view showing a first embodiment of the present invention, and FIG. 2 is a schematic perspective view showing an operation state of the same embodiment. There are various types of inserts according to the present invention, as will be exemplified later. In this embodiment, an indwelling needle will be described.

  As shown in FIG. 1, the indwelling needle 10 of the present embodiment has an outer needle portion 11 and an inner needle portion 15. For example, the arterial vein of a dialysis apparatus used for infusion of an arteriovenous fluid such as an infusion or artificial dialysis Used for anchoring. The outer needle portion (usually referred to as a catheter) 11 includes an outer needle hub (catheter hub) 12 constituting a large diameter portion, and an outer needle 13 made of a soft resin provided at the proximal end of the outer needle hub 12. It consists of and. As a constituent material of the outer needle hub 12, a material made of transparent (colorless and transparent), colored transparent or translucent resin and ensuring internal visibility is preferable, for example, polyethylene, polypropylene, ethylene-vinyl acetate. Various resin materials such as polyolefin such as copolymer, polyurethane, polyamide, polyester, polycarbonate, polybutadiene, polyvinyl chloride and the like can be mentioned. The material of the outer needle 13 is preferably a resin material, in particular, a soft resin material, and specific examples thereof include, for example, a fluorine resin such as PTFE, ETFE, and PFA, an olefin resin such as polyethylene and polypropylene, or the like. These mixtures, polyurethane, polyester, polyamide, polyether nylon resin, a mixture of the olefin resin and an ethylene-vinyl acetate copolymer, and the like. It is preferable that all or part of the outer needle 13 has internal visibility. That is, the outer needle 13 is preferably composed of a transparent (colorless and transparent), colored transparent or translucent resin. Thereby, when the outer needle 12 secures a blood vessel, a phenomenon (flashback) in which blood flows into the outer needle hub 12 through the inner needle 17 described later can be visually confirmed. In addition, in the constituent material of the outer needle 13, for example, an X-ray contrast agent such as barium sulfate, barium carbonate, bismuth carbonate, tungstic acid, or an MRI visualizing agent such as gadolinium salt is blended to provide a contrast function. Can also be given.

  The inner needle portion 15 is provided on the inner needle hub 16 provided in the central portion, the metal inner needle 17 provided on the proximal end side of the inner needle hub 16, and the distal end side of the inner needle hub 16. The filter 18 and the filter cap 19 are formed. As the material of the inner needle hub 16, the same material as that of the outer needle hub 12 can be used. Examples of the material of the inner needle 17 include a metal material such as stainless steel, aluminum or an aluminum alloy, titanium or a titanium alloy.

  The indwelling needle 10 is usually stored and stored in a sealed case (not shown) with the inner needle 17 inserted into the outer needle 13.

  The indwelling needle 10 is used as follows. First, the indwelling needle 10 with the inner needle 17 inserted into the outer needle 13 is punctured into the living body. Then, by removing only the inner needle 17, the outer needle 13 is left in the living body, and then, for example, when performing infusion, the infusion tube is connected to the outer needle hub 12.

  The outer needle 13 placed in the living body has a gap between the living body and the outer needle 13. As shown in FIG. 1, the indwelling needle 10 of this embodiment has an antibacterial property against a living tissue and fluidity in the indwelling needle 10 of this embodiment so that the pharmaceutical composition Y1 is applied to the gap. Also provided is a bag-like bag (corresponding to a housing part) B in which a pharmaceutical composition Y1 is also enclosed. The bag B is provided with at least a weak seal portion (corresponding to the opening portion) J having a different sealing strength, and the weak seal portion J of the bag B is ruptured to remove the pharmaceutical composition Y1 from the outer needle. It is made to flow out toward the gap between the part 11 and the living tissue.

  Specifically, a bag B for storing the pharmaceutical composition Y1 is provided on the distal end side of the outer needle hub 12 in the outer needle portion 11 (the distal end portion of the catheter hub formed with a larger diameter than the outer needle 13). The outer needle 13 is inserted obliquely from above with respect to the surface of the living body and is left in an inclined state. However, in a normal procedure, the outer needle 13 is basically inserted into the living body up to the vicinity of the outer needle hub 12 (the tip of the catheter hub). Therefore, when the bag B is provided on the upper part of the outer needle hub 12 which is a position near the hand in the state after the insertion, the user inserts the bag B after inserting the outer needle 13 into the living body. It becomes easy to apply the pressing force P for the bursting operation.

  The position where the bag B is provided is not necessarily limited to the upper portion of the outer needle hub 12 (catheter hub tip), but may be a side portion or a lower portion, an intermediate position between the upper portion and the side portion, Any position may be provided as long as it is located on the outer needle hub 12 and can flow out the pharmaceutical composition Y1 on the outer circumference of the catheter. The bag B may be configured to be detachable from the outer needle portion 11. In such a configuration, after inserting the outer needle part 11 into the living body, an operation of causing the bag B to be attached to the outer needle part 11 and causing the drug composition Y1 to flow out may be performed, or the drug composition Y1 may be discharged. The bag B may be attached to the outer needle portion 11 before performing the operation.

  Then, when the weak seal portion J of the bag B is ruptured by the applied pressure P, the drug composition Y1 flows out from the bag B as indicated by an arrow in FIG. The pharmaceutical composition Y1 flows from the outer needle hub 12 along the outer needle 13 due to gravity, and is directed to the gap between the living body and the outer needle 13. Since the pharmaceutical composition Y1 has not only fluidity but also antibacterial properties, it closes the gap between the living tissue and the insertion member, and covers the peripheral portion of the insertion portion, greatly increasing the risk of infection and inflammation. Can be reduced. Therefore, the user only needs to insert the outer needle 13 into the living body and apply a pressure P that ruptures the weak seal portion J of the bag B, and the gap between the outer needle 13 and the living tissue and the periphery of the insertion portion. Contamination of the part can be prevented by the pharmaceutical composition Y1. In particular, since the user can independently perform an operation of inserting the outer needle 13 into the living body and an operation of rupturing the weakly sealed part J, the user can perform a desired operation after repeating the operation of inserting the outer needle 13. It becomes effective when set to the position of. Note that the pressure P for rupturing the weak seal portion J of the bag B can be arbitrarily set according to the use form, but places an excessive burden on the user by pressing with the user's hand. It is preferably set within a range in which the bag B can be opened without any problem, and in the present embodiment, for example, it is set to about 0.1 to 5 N / 10 mm, particularly preferably about 0.3 to 3 N / 10 mm. can do. Further, the bag B may be formed very small together with the outer needle portion 11, but in such a case, it is difficult to apply the pressure P to the bag B by the user's hand, so that the bag B is easily pressed. Accordingly, an opening tool (not shown) for easily applying the pressure P to the bag B can be attached to and detached from the insert.

  In particular, the pharmaceutical composition is not used wastefully or disappears, and after inserting and setting the outer needle 13, a predetermined amount of the pharmaceutical composition Y1 can be appropriately applied by one rupture operation. Is greatly improved. That is, as a device for applying the pharmaceutical composition Y1, a device that applies the pharmaceutical composition Y1 to the outer peripheral surface of the outer needle 13 is also conceivable. Compared with such a device, the pharmaceutical composition Y1 is used wastefully. The procedure can be performed well without being lost or lost.

  The bag B for storing the drug composition Y1 may be any soft material as long as it has a property that does not react with the drug composition Y1. It is preferable that it contains. As a material for forming the flexible bag 2, polyethylene or polypropylene, a styrene thermoplastic elastomer such as a styrene-butadiene copolymer or a styrene-ethylene-butylene-styrene block copolymer, or an ethylene-propylene copolymer is particularly preferable. And a soft resin that is softened by blending an olefinic thermoplastic elastomer such as an ethylene-butene copolymer or a propylene-α-olefin copolymer.

  The bag B may be always attached to the outer needle 13 or may be formed independently and attached at the time of use. For example, when it is always attached, a known technique such as adhesion using an adhesive, fusion, or a method utilizing the tackiness of the material of the bag B itself can be used.

  As the pharmaceutical composition Y1 to be accommodated in the bag B, any pharmaceutical composition Y1 can be used as long as it closes the gap between the outer needle 13 and the living tissue when the outer needle 13 is inserted into the living body. However, in the present embodiment, it is easy to enter the living body together with the outer needle 13, and is composed of a drug having antibacterial properties in order to prevent infection. Further, the pharmaceutical composition Y1 is preferably a liquid having fluidity because it travels along the outer needle 13 as described above, and has an appropriate adhesive property capable of closing the gap between the outer needle 13 and the living tissue. It is preferable that it is a chemical | medical agent which has.

  Furthermore, the pharmaceutical composition Y1 may be composed of a bioabsorbable and degradable material. With such a material, when the outer needle 13 is indwelled in the living body, the adjustment of the indwelling period becomes unnecessary or the adjustment becomes easy.

  Specific examples of the pharmaceutical composition Y1 include, for example, cyanoacrylate adhesives such as 2-octyl cyanoacrylate and 2-cyanoacrylate monomer, such as polyacrylamide, polyvinyl alcohol, polyvinyl ethyl ether, modified collagen, polyvinyl Examples include hydrogels such as pyrrolidone, gelatin, and hydroxyethyl methacrylate, and elastomers such as polyurethane, polyether urethane urea, silicone elastomer, polymethyl methacrylate, polyethylene glycol, and esters thereof.

  Antibacterial agents to be added to this include, for example, penicillins, cephems, monobactams, carbapenems, aminoglycosides, new quinolones, macrolides, clindamycin, tetracyclines, metronidazole, ST mixtures, glycopeptides , Streptogramin, oxazolidinone, lipopeptide, glycylcycline, glycopeptide, chloramphenicol, ketolide and other antibacterial agents, nucleic acid protein inhibitors, pyridone carboxylic acid synthesis Antibacterial agents, folic acid metabolism inhibitors such as chlorhexidine, povidone iodine, iodine tincture, ethanol, isopropanol, isopropyl alcohol, oxidol and other antiseptics, and metal ions such as silver, copper, zinc and the like. What is necessary is just to select these suitably and accommodate in the bag B.

When the indwelling needle 10 described above is stored in a sealed case (not shown), a checker may be stored in the sealed case together with a desiccant, an oxygen scavenger, or these. In this way, alteration of the pharmaceutical composition Y can be prevented and stored for a long time. Further, even during use, whether or not it can be used can be determined by visually checking the checker, and convenience is improved.
(Second Embodiment)
FIG. 3 is a main part schematic perspective view showing a second embodiment of the present invention, and FIG. 4 is a main part schematic perspective view showing a modification of the same embodiment. In the present embodiment, as shown in FIG. 3, the bag B that stores the pharmaceutical compositions Y2 and Y3 is partitioned into a plurality of storage chambers R1 and R2 by the partition wall S, and the flow of the different properties in each of the storage chambers R1 and R2 Sexual drug compositions Y2 and Y3 are contained, two different drug compositions Y2 and Y3 are mixed by the rupture operation of the bag B, flow along the outer peripheral surface of the outer needle 13, and the outer needle 13 and the living tissue. I try to get into the gap between. In addition, as shown in FIG. 3, the arrangement | positioning of storage chamber R1, R2 separated by the partition S may be right and left of an axial direction, and may be up and down with respect to an axial line. It is not limited.

  In the first embodiment, the drug composition is sealed in a single bag B, but in this embodiment, different drug compositions Y2 and Y3 are sealed in the respective storage chambers R, and both are mixed. And antibacterial properties, fluidity and adhesiveness. A method for mixing the two is not particularly limited, and there is a method in which the partition wall S that separates the storage chamber R1 and the storage chamber R2 is connected by the weak seal portion J1. In this case, by pressing the bag B by setting the seal strength of the weak seal portion J1 of the storage chamber R1 and the storage chamber R2 to be weaker than the strength of the weak seal portion J2 of the portion flowing out from the storage chamber R1, First, the liquid moves from the storage chamber R2 to the storage chamber R1, and then the liquid moves from the storage chamber R1 to the outside, so that both drug compositions Y2 and Y3 can be mixed reliably.

  Further, as shown in FIG. 4, the positional relationship of the weak seals between the storage chamber R1 and the storage chamber R2 intersects, that is, after being pushed out, both drug compositions Y2 and Y3 are mixed. Any arrangement may be acceptable.

  Specifically, examples of the pharmaceutical composition Y2 include high biocompatible polymers such as PEG and PVA having alginic acid, trilysine and ester active groups, or aldehyde groups, and the pharmaceutical composition Y3 includes For example, a low molecular compound having Ca, PEG ester and an amine group, an imide group or the like, or a polymer having high biocompatibility such as PEG and PVA can be used.

In particular, in the embodiment shown in FIG. 3, since the two storage chambers R1 and R2 are independently arranged with the partition wall S therebetween, the mixing of the pharmaceutical compositions Y2 and Y3 can have a time difference. The release point of the pharmaceutical composition Y2 or Y3 can be adjusted as appropriate according to the state, and the versatility or convenience of the procedure is improved. Needless to say, the number of storage chambers R is not limited to two, and can be set to an appropriate number according to the type or procedure of the pharmaceutical composition Y to be used.
(Third embodiment)
FIG. 5 is a schematic perspective view showing a third embodiment of the present invention. As shown in FIG. 5, this embodiment is effective when the distal end portion 13 a of the outer needle 13 is scraped off so that the inclination angle θ with respect to the axis X of the outer needle 13 becomes an acute angle.

  That is, when the distal end portion 13a of the outer needle 13 is cut off, it is usually inserted into the living body with the slope of the distal end portion 13a facing up. Accordingly, when the bags B1 and B2 are provided at positions that face the upper and lower sides of the catheter hub 12, the bags B1 and B2 can be broken from the upper and lower sides and the internal drug compositions Y2 and Y3 can flow out during normal operation. B1 and B2 can be ruptured by a natural operation, and it becomes an easy-to-use device that can be used without feeling uncomfortable at the time of rupture.

  In the present embodiment, an appropriate number of bags B may be provided corresponding to the number of drug compositions Y and the like.

In addition, the drug composition Y may be all colored with a single color, and in some cases, the drug compositions Y2 and Y3 may be individually colored with a specific color. In any case, when the pharmaceutical composition Y is colored, when the outer needle 13 is inserted, the pharmaceutical composition itself becomes a kind of standard, and the range of the puncture portion of the outer needle 13 and the sealing condition are visually confirmed. The procedure can be performed smoothly and reliably. Visualizing agents include, for example, vitamin colorants such as L-ascorbic acid (vitamin C), calcium L-ascorbate, and stearates, amaranth, erythrosin, allura red AC, new coxin, phloxine, acid red, tartrazine, sun Food colorants such as Set Yellow FCF, Fast Green, Carminic Acid, etc. are mentioned (fourth embodiment).
6A to 6C are schematic perspective views showing a fourth embodiment of the present invention. This embodiment is different from the above-described embodiments in that the outer needle portion 11 constituting the insert is provided with a guide portion 14 for guiding the flow of the pharmaceutical composition. The guide part 14 guides the flow of the drug composition so that the drug composition that has flowed out of the bag B travels along the outer needle part 11 and flows down toward the gap between the outer needle part 11 and the living tissue. It has the function to do.

  In addition, although the outer needle hub 12 and the outer needle 13 are provided as separate bodies as the outer needle portion 11 according to the present embodiment and the two members are assembled, the outer needle portion 11 is shown as having an outer needle portion 11. The needle portion 11 is not limited to such a configuration, and for example, an outer needle hub 12 and an outer needle 13 that are integrally manufactured in advance as shown in the above-described embodiments may be used.

  As shown in FIG. 6A, the guide portion 14 can be constituted by, for example, a groove 14 a provided at the tip of the outer needle hub 12 and a groove 14 b provided in the outer needle 13. The drug composition discharged from the bag B flows down along the groove 14a, and then flows down along the groove 14b. As shown in the figure, when the lower end of the groove 14a and the upper end of the groove 14b are arranged close to each other, the drug composition can flow more smoothly from the outer needle hub 12 to the outer needle 13. Then, the drug composition that has flowed into the groove 14 b flows out from the lower end of the groove 14 b and is guided to the gap between the living tissue and the outer needle portion 11.

  Thus, by providing the guide portion 14, a smooth flow of the pharmaceutical composition from the bag B to the gap between the living tissue and the outer needle portion 11 can be formed. 11 can be easily and quickly applied to the gap between the two and the periphery thereof. Thereby, the convenience of this device can be improved further.

  For example, side walls 24 as shown in FIG. 6B can be provided in the guide portion 14. The side wall 24 prevents the drug composition from inadvertently flowing out of the grooves 14a and 14b when the drug composition flows down, and the drug composition drips or adheres to a site where application is not planned. Is prevented. Therefore, by providing the side wall 24 together with the guide portion 14, it is possible to apply the pharmaceutical composition in the gap between the living tissue and the outer needle portion 11 without waste.

  Further, for example, as shown in FIG. 6C, a curved shape having a guide function can be given to a predetermined part of the outer needle 13, and this part can be made to function as the guide part 14. As shown in the drawing, the curved portion constituting the guide portion 14 is formed so that the outer diameter gradually increases from the root portion of the outer needle 13 located on the outer needle hub 12 side toward the distal end side of the outer needle 13. be able to. The pharmaceutical composition flowing down from the outer needle hub 12 flows down to the distal end side of the outer needle 13 via the guide portion 14 provided on the outer needle 13. At this time, the pharmaceutical composition flows down to the distal end side along the curved shape of the guide portion 14 and is guided to the gap between the living tissue and the outer needle portion 11. According to such a guide portion 14, even when a step is formed at the connecting portion of both members due to a dimensional difference between the outer diameter of the outer needle hub 12 and the outer diameter of the outer needle 13, the outer needle hub. The pharmaceutical composition can smoothly flow from 12 to the outer needle 13.

  The present invention is not limited to the embodiments described above, and various modifications can be made by those skilled in the art within the technical idea of the present invention. For example, in the above-described embodiment, the outer needle of the indwelling needle has been described as the insert. However, the present invention is not limited to this, and examples of the target of the insert include a blood vessel catheter, a urinary catheter, and a hard needle. There are various catheters such as an extramembranous catheter, or an indwelling needle, a Huber needle insertion part, an indwelling drain, a peritoneal dialysis tube, a cable of a biologically implantable medical device, and a tracheostomy cannula.

  In addition, the present invention provides a medicine composition that has flowed out of a container provided in the insert, and flows down along at least a part of the insert, thereby forming a gap between the insert and the living tissue. Each configuration can be changed as long as the function of guiding the pharmaceutical composition can be exhibited. For example, in each embodiment, although the form which utilized the bag-like bag was shown for the accommodating part which accommodates a pharmaceutical composition, the accommodating part changes as long as it has the function which can accommodate and hold | maintain a pharmaceutical composition. For example, a container made of a hard or soft resin material can be used instead of the bag. The opening part that opens the housing part can also be changed as long as the housing part has a configuration that can be opened, and instead of the weak seal part, for example, by a fitting cap, an operation such as pressing or pulling. It is possible to appropriately select from well-known members used for performing the outflow operation of fluid and fluid, such as a cap to be broken and a cap having a valve body provided with an opening / closing mechanism.

  INDUSTRIAL APPLICATION This invention can be utilized as a pharmaceutical composition application | coating device which apply | coats a chemical | medical agent in the clearance gap between the insertion body inserted and detained in a biological body, and a biological tissue, and the peripheral part of an insertion part.

10 ... pharmaceutical composition application device,
11 ... outer needle part (insert)
12 ... Outer needle hub (large diameter part),
13 ... outer needle (insertion member),
14 ... Guide part,
B (B1, B2) ... bag (accommodating part),
J (J1, J2) ... weak seal part (opening part),
R1, R2 ... containment chambers,
S ... partition wall,
Y (Y1, Y2, Y3) ... drug.

Claims (7)

A pharmaceutical composition application device for applying a pharmaceutical composition to a gap between an insert inserted into a living body and a biological tissue,
The insert;
A container provided in the insert, the container having an antibacterial property against the living tissue and having fluidity;
An opening part that can freely open the housing part,
The insert has a guide portion that guides the flow of the drug composition so that the drug composition flows down the gap through the insert.
The drug composition application device, wherein the drug composition flowing out along with the opening of the container is guided to the gap by flowing along at least a part of the insert. The container is constituted by a bag-like bag that can enclose the pharmaceutical composition;
The opening portion is constituted by a weak seal portion having a weak seal strength provided in at least a part of the bag,
The device for applying a pharmaceutical composition according to claim 1, wherein the bag is opened by breaking the weak seal portion.   The bag has a plurality of storage chambers partitioned by a partition wall, stores different drug compositions in the respective storage chambers, and mixes the different drug compositions by a rupture operation of the bag. The pharmaceutical composition application device according to claim 2.   The pharmaceutical composition according to claim 2 or 3, wherein the bag comprises a plurality of bags each containing different pharmaceutical compositions, and the different pharmaceutical compositions are mixed by a bursting operation of these bags. Application device.   The insert has an insertion member inserted into a living body and a large-diameter portion provided on the proximal end side of the insertion member, and the accommodating portion is provided in the large-diameter portion. The pharmaceutical composition application device according to any one of claims 1 to 4.   6. The pharmaceutical composition application device according to claim 5, wherein the insertion member is an indwelling needle in which the insertion member is an outer needle and the large-diameter portion is constituted by a catheter hub.   The drug composition application device according to claim 1, wherein the drug composition is colored with a specific color.

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