JP5931615B2 - Chemical solution storage device and chemical solution storage method using the storage device - Google Patents

Description

  The present invention relates to a storage device capable of protecting a chemical solution stored in a chemical solution storage container from drying and storing it for a long period of time, and a method for storing a chemical solution using the storage device.

  For example, clinical diagnostics and the like containing a chemical solution such as an influenza test drug based on the immunochromatography method as a component are usually contained in a small amount in a container. In addition, the container containing this kind of chemical solution can be immersed in the chemical solution in the container so that the appropriate amount of the chemical solution can be dripped through the drop stopper by pressing the side of the container with a finger. After being made, it is often formed of a soft material so that the chemical solution impregnated in the cotton swab with the container can be squeezed by sandwiching the side of the container with fingers. Specifically, a soft synthetic resin is generally used as such a soft material, and among them, low density polyethylene (LDPE) and linear low density polyethylene (LLDPE) are mainly used. However, since such a soft synthetic resin has a low density, the water in the chemical contained in the container becomes water vapor and passes through the container wall. In the end, there was a problem that the chemical solution dried up and could not be used.

  In order to solve such problems, this type of chemical container is stored and stored in a bag made of a film having a gas barrier property.

  These chemical solution storage containers can be stored for a long period of time by being stored in a bag made of an aluminum foil laminate film having the best gas barrier properties. However, since the aluminum foil laminate film is opaque, the inside of the bag cannot be visually recognized, and it is necessary to take out and check the chemical container from the bag each time in order to check the number of containers and the amount of the chemical solution stored. There was a problem that it was inconvenient in use. Furthermore, even when manufacturing a clinical diagnostic kit or the like including this type of chemical container as a component, whether or not the number of chemical containers stored in the bag is appropriate and whether the chemical liquid has leaked from the chemical container There has been a problem that it is impossible to confirm such as promptly.

  On the other hand, as a film having a gas barrier property with visibility, there is a bag made of a transparent vapor deposition film such as silica or alumina. However, these transparent vapor-deposited films are inferior in gas barrier properties compared to aluminum foil laminate films, so even if this type of chemical solution storage container is stored, the chemical solution will decrease and should be stored for more than one year. Was difficult. Therefore, there has been a problem that clinical diagnostic agents for seasonal diseases (for example, seasonal influenza) cannot be used in the following season.

  The present invention has been devised in view of the above points, and its purpose is to prevent a chemical solution stored in a container made of a soft synthetic resin from being dried for a long period of time and to store a chemical solution using the same. It is to provide a method.

  Another object of the present invention is to provide a container made of a soft synthetic resin over a period equivalent to or longer than that of a bag made of an aluminum foil laminate film even when a bag made of a transparent film having visibility is used. It is an object of the present invention to provide a storage device that can prevent the chemical solution contained in the container from being dried and store it for a long period of time and a method for storing the chemical solution using the storage device.

  In order to solve the above-mentioned problems, a chemical solution storage device according to the present invention includes a sealed container, at least one chemical solution storage container accommodated in the sealed container, and a humidifying material accommodated in the sealed container. Is constituted by a bag body containing at least water, and the bag body includes an inner layer made of a synthetic resin film and an outer layer made of a nonwoven fabric.

  The chemical | medical solution storage apparatus of this invention is equipped with the airtight container, the at least 1 chemical | medical solution storage container, and the humidification material. The chemical solution storage container and the humidifying material are stored in a sealed container. In the present invention, the closed container refers to a container that can prevent solids and liquids from being mixed from the outside.

  The humidifying material in the storage device of the present invention is constituted by a bag body including an inner layer made of a synthetic resin film and an outer layer made of a nonwoven fabric. The water contained in the bag of the humidifying material is in contact with the inner layer of the bag made of a synthetic resin film, and the synthetic resin film has a property of passing water vapor (moisture permeability) while hardly allowing water to pass through. ing. Therefore, water vapor in the bag of the humidifying material gradually passes through the inner synthetic resin film and reaches the non-woven fabric of the outer layer of the bag. Moreover, the non-woven fabric has small holes formed between the fibers constituting the nonwoven fabric, and has high moisture permeability. Therefore, the water vapor passes through the outer nonwoven fabric and reaches the outside of the humidifying material to adjust the humidity in the sealed container. On the other hand, when the humidity in the sealed container increases due to a rapid temperature change in the environment, and the like, dew condensation or the like occurs, the outer layer of the humidifying material bag made of nonwoven fabric can absorb water. Thus, the storage device of the present invention prevents the moisture in the chemical solution stored in the chemical solution container from permeating out of the chemical solution storage container by suitably adjusting the humidity in the sealed container by the humidifying material, Prevents the chemical solution from drying and can be stored for a long time. Further, even when the hermetic container is opened and closed during the storage period in order to take out a part of the stored chemical liquid container, the humidity in the sealed container after the humidifier is opened and closed can be suitably adjusted. Can be stored for a long period of time.

  Further, the outer layer of the bag of humidifying material is formed from a non-woven fabric, so that, for example, when the chemical container is in contact with the bag in a sealed container during transportation, manufacture, storage, etc. The shock applied to the surface is absorbed, and it is possible to prevent the bag body from opening a hole and the bag body from being damaged.

  Moreover, it is also preferable that a bag body consists of a laminated body formed by bonding a synthetic resin film to a nonwoven fabric. Since the bag is composed only of a laminated nonwoven fabric formed by laminating a synthetic resin film and a nonwoven fabric, the humidifying material is formed with a simple configuration. Furthermore, since the synthetic resin films are disposed on the inner layer of the bag body, the inner layer is easily heat-sealed by heat sealing or welding without affecting the material of the outer layer, and the bag body is easily manufactured. be able to.

  Moreover, it is also preferable that a nonwoven fabric consists of a water absorbing material. The non-woven fabric that forms the outer layer of the bag body is made of a water-absorbing material. Can be absorbed.

  The bag body preferably further contains an antibacterial agent. By including an antibacterial agent in the bag body containing the water constituting the humidifying material, the water contained in the bag body of the humidifying material is affected by bacteria, mold, etc. during long-term storage, Can prevent corruption. Furthermore, when the antibacterial agent contained in the bag body becomes a gas and reaches the outside of the bag body, in order to show antibacterial action against bacteria and molds present in the sealed container, Can be kept clean.

  In the method for storing a chemical solution of the present invention, the chemical solution is stored in a chemical solution storage container in the chemical solution storage device, the chemical solution storage container containing the chemical solution and the humidifying material are stored in a sealed container, and the sealed container is sealed.

  The humidifying material accommodated in the sealed container together with the chemical solution container adjusts the humidity in the sealed container, thereby preventing moisture of the chemical solution from permeating out of the chemical solution container and preventing the chemical solution from drying.

  Moreover, it is also preferable that the amount of water is adjusted so that the humidification material may contain water until the desired storage period. Since the humidifying material contains water until the desired storage period, it is possible to stably prevent the chemical solution from drying.

  Furthermore, the adjustment of the amount of water is performed by previously storing a test water bag containing a predetermined amount of water inside a bag body in a test container made of substantially the same material as the sealed container, and sealing the test container. Then, the change in the amount of water contained in the test water bag is measured over time, the amount of water in the test water bag in the sealed container is calculated until the desired storage period, and the water contained in the humidifying material is calculated. It is also preferable that the amount is set to be equal to or more than the calculated reduction amount of water.

  Adjustment of the amount of water contained in the humidifying material is performed as follows. Reduce the amount of water in the test water bag by using a test container composed of substantially the same material as the sealed container used for preserving the chemical solution container and a test water bag composed of a humidified bag. By measuring the amount over time, the correlation between the passage of time and the amount of decrease in water under these conditions is studied, and a regression line, approximate curve, etc. can be obtained. The amount of water decrease in the test water bag in the sealed container until the desired storage period can be calculated from the obtained regression line or the like. By making the amount of water contained in the humidifying material equal to or greater than the calculated amount of water reduction, the humidifying material is maintained in a state where water is contained until the desired storage period, and the chemical solution is stably dried. Can be prevented. The material substantially the same as the sealed container in the present invention refers to a material that is substantially the same material as the material that constitutes the sealed container or a material that has substantially the same film structure as the film configuration that constitutes the sealed container. The material which shows the water vapor transmission rate substantially the same as the material of an airtight container.

ADVANTAGE OF THE INVENTION According to this invention, the preservation | save apparatus of the chemical | medical solution which has the following outstanding effects and the preservation | save method of the chemical | medical solution using this preservation | save apparatus can be provided.
(1) When the humidifying material adjusts the humidity in the sealed container, moisture in the chemical solution can be prevented from permeating out of the chemical solution storage container, and drying of the chemical solution can be prevented.
(2) Until the desired storage period, it is possible to maintain a state in which water is contained in the humidifying material and to stably prevent the chemical solution from drying.

1 is a diagram schematically showing a chemical liquid storage device according to an embodiment of the present invention. FIG. It is the front view which shows the (a) humidification material in the chemical | medical solution preservation | save apparatus which concerns on embodiment of FIG. 1, (b) It is sectional drawing of the A-A 'line. It is a figure which shows schematically the state which accommodated the chemical | medical solution storage container and the humidification material in which the chemical | medical solution was accommodated in the preservation | save apparatus of the chemical | medical solution which concerns on embodiment of FIG. It is a graph which shows the relationship between the reduction | decrease amount of the water in the test water bag accommodated in various test containers, and the storage days, and its regression line. It is a graph which shows the relationship between the reduction | decrease amount of a chemical | medical solution, and the preservation | save days in the preservation | save apparatus of various sealed containers in an Example, and (b) the graph which shows the regression line.

  Hereinafter, embodiments of the present invention will be described.

  As shown in FIGS. 1 and 3, a chemical solution storage device 1 according to an embodiment of the present invention includes a sealed container 2, at least one chemical solution storage container 3, and a humidifying material 4.

  As shown in FIG. 1, the sealed container 2 is composed of a bag provided with a chuck 21 for enabling the container to be sealed. In the present embodiment, a bag is shown as an example of the sealed container 2, but a box or other shaped container can be used as long as it can be sealed. As the size of the sealed container 2, a size capable of storing the chemical solution storage container 3 and the humidifying material 4 is selected.

  The material of the sealed container 2 is not particularly limited, but a synthetic resin is preferable, a synthetic resin film such as polyethylene, polypropylene, nylon or polyester, a synthetic resin multilayer film combining these, a transparent vapor deposition film such as silica or alumina, an aluminum foil A laminate film, an aluminum vapor deposition film, etc. are mentioned. In particular, when the airtightness of the airtight container 2 is low, water vapor can be contained inside the airtight container 2, and from the viewpoint that water vapor can be suitably prevented from passing through the chemical solution storage container 3, a laminated film having gas barrier properties, that is, Further, a synthetic resin multilayer film, a transparent vapor deposition film such as silica or alumina, an aluminum foil laminate film or an aluminum vapor deposition film is preferable, and a transparent vapor deposition film such as silica or alumina is more preferable from the viewpoint of high visibility.

  Next, the chemical solution storage container 3 will be described. As shown in FIG.1 and FIG.3, the chemical | medical solution storage container 3 in this embodiment is a small-capacity container provided with the screw cover generally called the squeeze tube or the dropper tube, and the container side surface is finger | toe. A suitable amount of medicinal solution contained by pressing can be dropped through the drop stopper, and / or after the sampled swab is immersed in the medicinal solution in the container, the side of the container is pinched with fingers and the entire swab is impregnated into the swab It is made of a soft material so that the applied chemical can be squeezed. The material of the chemical solution container 3 is low in density and has a property that allows the moisture of the chemical solution contained in the container to permeate. As an example, a soft synthetic resin can be cited. Density polyethylene (LDPE) and linear low density polyethylene (LLDPE) are selected.

  Next, the humidifying material 4 will be described. As shown in FIGS. 2 (a) and 2 (b), the humidifying material 4 is composed of a bag body 42 that contains an inclusion 43 such as water and an antibacterial agent. Since the inner layer 40a of the bag body 42 is in contact with the water contained therein, a synthetic resin film that is difficult to pass water as a liquid is selected, and the outer layer 40b of the bag body 42 is a non-woven fabric having high moisture permeability and water absorption. Is selected. As the synthetic resin film of the inner layer 40a, it is sufficient if water is hardly passed, but water vapor can pass therethrough (moisture permeability), and examples thereof include synthetic resin films such as polyethylene, polypropylene, nylon or polyester.

  As the nonwoven fabric of the outer layer 40b, a general nonwoven fabric having moisture permeability can be used. Since the nonwoven fabric is formed of fine fibers, if condensation or water droplets are generated in the sealed container due to a sudden temperature change in the environment, the water droplets or condensation are absorbed by the capillary phenomenon and held in the outer layer 40b of the bag body 42. can do. In order to increase the water absorption of the outer layer 40b, the nonwoven fabric is preferably made of a water-absorbing material. For example, a nonwoven fabric made of hydrophilic fibers such as rayon fibers, a nonwoven fabric subjected to hydrophilic processing or hydrophilic agent treatment, or a pulp nonwoven fabric. Is more preferably used. Thereby, the dew condensation and the water droplet which arose in the airtight container can be absorbed more reliably. In particular, a rayon nonwoven fabric formed of rayon fibers is excellent in hydrophilicity, water absorption and moisture release properties, and can be suitably used as a nonwoven fabric used in the present invention. Furthermore, cushioning properties and impact buffering properties are imparted to the bag body 42 by forming the outer layer 40b from a nonwoven fabric. Therefore, even when the chemical container 3 comes into contact with the bag body 42 in the sealed container 2 during transportation, manufacture, storage, etc., the impact applied to the surface of the bag body 42 is a non-woven fabric of the outer layer 40b. The synthetic resin film that is buffered and forms the inner layer 40a of the bag body 42 can be prevented from being pierced or torn, and the bag body 42 can be prevented from being damaged.

  In the sheet 40 constituting the bag body 42, the inner layer 40a and the outer layer 40b described above, that is, the nonwoven fabric and the synthetic resin film may be formed separately, but as shown in the present embodiment, From the viewpoint that the sheet constituting the bag body 42 becomes a single sheet and has a simple structure, it may be integrated. The bag body 42 in the present embodiment is composed of a laminated sheet 40 formed by laminating a synthetic resin film on a nonwoven fabric. The inner layer (inner surface) 40a of the bag body is a synthetic resin film and the outer layer (surface) 40b is a nonwoven fabric. It is configured.

  As shown in FIGS. 2A and 2B, the bag body 42 of the humidifying material 4 is obtained by welding the outer periphery of the sheet 40 by heat sealing or the like. At this time, the inner layer 40a of the bag body is disposed so as to be a synthetic resin film, and the outer layer 40b is a nonwoven fabric, and the outer periphery is welded. Since the synthetic resin films constituting the inner layer 40a are suitably welded by heat, the bag body 42 can be easily manufactured. The bag body 42 may have a tube shape, a box shape, or a capsule shape in addition to the bag shape as shown in the present embodiment.

  As shown in FIG. 2B, the bag body 42 of the humidifying material 4 contains an inclusion 43 mainly made of water. In order to prevent water decay during the storage period, the inclusion 43 can contain an antibacterial agent. In addition, when the antibacterial agent contained in the bag body 42 becomes a gas and reaches the outside of the bag body 42, in order to exhibit antibacterial action against bacteria, mold, etc. present in the sealed container 2, The inside of the sealed container 2 is kept clean. The antibacterial agent in the present invention is a concept including a fungicide, a fungicide, an antibiotic and the like. As the antibacterial agent, an antibacterial agent contained in the bag body 42 is preferably a gas that does not affect the drug solution when it reaches the outside of the bag body 42 as a gas, and is not particularly limited. For example, alcohol such as ethanol , Paraoxybenzoic acid ester (paraben), benzoic acid or its salt, sorbic acid or its salt, quaternary ammonium salt, phenol, chlorhexidine, alkyldiaminoethylglycine hydrochloride, sodium azide, thimerosal, etc., or a combination thereof Can be mentioned. Furthermore, in the inclusion 43 contained in the bag body 42 of the humidifying material, in addition to water and the antibacterial agent, filter paper for supporting water and the antibacterial agent, polymer absorbent body (SAP), cloth, cotton or non-woven fabric Etc. can also be included.

  Next, a chemical solution storage method using the chemical solution storage device 1 according to the present invention will be described. As shown in FIG. 3, the chemical solution 30 is stored in the chemical solution storage container 3, and the chemical solution storage container 3 and the humidifying material 4 are stored in the sealed container 2. And the chuck | zipper 21 with which the airtight container 2 was equipped is closed, and the airtight container 2 is sealed. When the humidity in the sealed container 2 decreases after sealing, the water vapor contained in the bag body 42 of the humidifying material 4 passes through the synthetic resin film of the inner layer 40a and reaches the nonwoven fabric of the outer layer 40b. Further, the water vapor passes through the outer layer 40b through the small holes present in the nonwoven fabric, reaches the outside of the humidifying material 4, and adjusts the humidity in the sealed container 2. Therefore, moisture in the chemical solution 30 stored in the chemical solution storage container 3 is prevented from permeating out of the chemical solution storage container 3, and drying of the chemical solution 30 is prevented. On the other hand, when the humidity in the sealed container 2 becomes high due to a sudden temperature change of the environment and the like, dew condensation occurs, the outer layer 40b of the bag body 42 of the humidifying material 4 made of nonwoven fabric absorbs water by capillary action. And preventing water in the sealed container 2 from getting wet. Thus, in the storage device 1 of the present invention, the humidifier 4 suitably adjusts the humidity in the sealed container 2, so that the water in the chemical solution 30 stored in the chemical solution storage container 3 is moved out of the chemical solution storage container 3. The chemical solution 30 is stored while preventing permeation and preventing drying of the chemical solution for a long period of time.

  Next, the amount of water contained in the bag body 42 of the humidifying material 4 will be described. It is preferable that the amount of water contained in the humidifying material 4 is adjusted so that water is contained in the humidifying material 4 until a desired storage period. Regarding the adjustment of the amount of water, when the amount of water in the humidifying material 4 decreases during the storage period, the humidifying material 4 is replaced with a new one, or additional water is injected into the humidifying material 4 using a syringe or the like. However, from the viewpoint of not having to adjust the amount of water during the storage period, it is preferable to set the amount of water in advance to a desired storage period. Hereinafter, a method for adjusting the amount of water contained in the bag body 42 of the humidifying material 4 will be specifically described below.

  Since the water vapor permeability varies depending on the material of the sealed container, the amount of water in the humidifying material is also affected by the material of the sealed container. In order to determine the amount of water that can be kept until the desired shelf life, the change in the amount of water in the humidifier was tested on four types of sealed containers as follows. A humidifying material for testing, i.e., as a test water bag, a bag body is formed of a sheet made of a laminated nonwoven fabric obtained by laminating a polyethylene film and a nonwoven fabric, and the bag body has a polyethylene film as an inner layer and a nonwoven fabric as an outer layer, A bag containing 5 mL of distilled water was used. The test container is a sealed container A made of an aluminum foil laminate film having a film configuration of PET 12 μm / PE 20 μm / AL 7 μm / PE 20 μm / PE 60 μm (produced by Nihon Co., Ltd., product name: Lamidip AL-11, width 11 cm × under chuck length 17 cm + (Closed gusset width 33 mm), sealed container B made of transparent deposited film of PET 12 μm / PE 20 μm / CPP 40 μm on which silica is deposited (produced by Nihon Co., Ltd., product name: Lamigrip VP-G, width 14 cm × chuck lower length 20 cm), a closed container C made of a low-density polyethylene film having a film thickness of 0.08 mm (produced by Nippon Co., Ltd., product name: Unipack G-8, width 14 cm × chuck length 20 cm) and film thickness 0.04 mm Low density polyethylene film An airtight container D (produced by Nippon Co., Ltd., product name: Unipack G-4, width 14 cm × under chuck length 20 cm) was used. The above test water bags are stored in these four types of test containers A to D, sealed, stored at 30 ° C. in a thermostatic bath, and the amount of water contained by taking out the test water bags approximately every week. Was measured. The test was performed with N number = 3 for each test container. The average value of the numerical values obtained by the measurement is shown in Table 1, and a graph plotting these values is shown in FIG.

  In FIG. 4, the horizontal axis represents the number of storage days (unit: days), and the vertical axis represents the amount of water reduction (unit: g). The amount of water in the test water bag decreased linearly for each of the four test containers. Based on these numerical values, a regression line was obtained for the relationship between the elapsed storage days and the amount of water decrease in the four types of test containers (FIG. 4). From the regression line thus obtained, the amount of water decrease in the test water bag in each sealed container until the desired storage period can be calculated. If the surface area of the test container is different from the actual surface area of the sealed container used for storing chemicals, the amount of water reduction in the test water bag is converted based on the actual surface area of the sealed container used. Can be calculated. Then, by setting the amount of water contained in the humidifying material to be equal to or greater than the calculated reduction amount of water, the humidifying material is maintained in a state where water is contained until the desired storage period, and the drying of the chemical solution is stabilized. Can be prevented. As an example, when test container B (silica vapor deposited PET) is used as a sealed container, the amount of water contained in the humidifying material when the storage period is set to 2 years is 0.0085 × 730 (day). = 6.2 g or more is preferable. Further, when the test container A (aluminum foil laminate) is used as a sealed container, 0.0016 × 730 days = 1.2 g or more is preferable when the storage period is 2 years.

  Thus, in advance, using a test container composed of substantially the same material as the sealed container 2 used when storing the chemical solution storage container 3, and a test water bag composed of the bag body 42 of the humidifying material 4, By measuring the amount of water decrease in the test water bag over time, the correlation between the passage of time and the amount of water decrease under these conditions is examined, and a regression line, approximate curve, or the like can be obtained. Based on the obtained regression line or the like, the amount of water decrease in the test water bag in the sealed container 2 up to a desired storage period can be calculated. Then, the amount of water in the humidifying material 4 is adjusted by setting the amount of water contained in the humidifying material 4 to be equal to or greater than the calculated amount of decrease in water.

  Hereinafter, the present invention will be described in detail with reference to examples.

(1) Sealed container made of silica-deposited PET film Using a laminated nonwoven fabric obtained by laminating a polyethylene film and a nonwoven fabric, a bag having an inner layer made of a polyethylene film and an outer layer made of a nonwoven fabric was prepared. After 5 mL of an aqueous solution containing 5% ethanol and 0.05% benzoic acid is injected into the bag with a syringe, the bag is heat-sealed so as to omit the needle hole portion of the syringe, and a humidifier with a size of 5 cm × 5 cm is added. Obtained. On the other hand, a squeeze tube with a screw cap of 2.5 mL made of low-density polyethylene (Shin Corporation product, product name: Dropper tube II) was prepared as a small volume chemical container. The squeeze tube contains 0.4 mL (400 mg) of the sample extract, and the tube lid is closed and sealed, and the weight of 10 squeeze tubes (the weight of the tube at the start of the test) is set. It was measured. Next, in a sealed container (produced by Nippon Co., Ltd., product name: Lamigrip VP-G, width 14 cm x length under chuck 20 cm) made of a transparent deposited film of PET 12 μm / PE 20 μm / CPP 40 μm on which silica is deposited. Ten squeeze tubes containing a humidifying material and 0.4 mL of solution were accommodated and sealed with a chuck. The container was stored under a temperature condition of 30 ° C., 10 squeeze tubes were taken out from the sealed container 32 days, 63 days and 92 days after the start of storage, and the weight per 10 squeeze tubes was measured. The test was performed with N number = 5. Table 2 shows the numerical values obtained by the measurement.

  Moreover, in the said test, it measured similarly to the above about the case where a humidification material is not used. The results are shown in Table 3.

  The average value of the measured values was calculated, and the average value of the amount of decrease in the chemical solution per squeeze tube was calculated. The results are shown in Table 4.

(2) Sealed container made of an aluminum foil laminate film Bag made of an aluminum foil laminate film with a film configuration of PET 12 μm / PE 20 μm / AL 7 μm / PE 20 μm / PE 60 μm (produced by Nihon Co., Ltd., product name: Lamidip AL-11, width 11 cm) The same test as in Example 1 was performed by using as the closed container (the length under the chuck 17 cm + the bottom gusset width 33 mm). However, the weight per 10 squeeze tubes was measured after 92 days and 136 days from the start of storage. The results are shown in Table 5 (with humidifier) and Table 6 (without humidifier).

  The average value of the measured values was calculated, and the average value of the amount of decrease in the chemical solution per squeeze tube was calculated. The results are shown in Table 7.

(3) Sealed container made of PE film Sealed bag made of low-density polyethylene film with a film thickness of 0.04 mm (produced by Nihon Pakaku Co., Ltd., product name: Unipack G-4, width 14 cm x length under chuck 20 cm) The same test as in Example 2 was performed using the container. However, only when no humidifier was used was tested. The results are shown in Table 8.

The average value of the measured values was calculated, and the average value of the amount of decrease in the chemical solution per squeeze tube was calculated. The results are shown in Table 9.

  About the test result of said (1)-(3), the graph which plotted the average value of the decreasing amount of the chemical | medical solution per squeeze tube is shown to Fig.5 (a). The horizontal axis of Fig.5 (a) is a preservation | save day (unit: day), and a vertical axis | shaft is the amount of reduction (unit: mg) of a chemical | medical solution. It was shown that the decrease due to the drying of the chemical solution is suppressed by arranging the humidifying material in the sealed container.

  Furthermore, the graph which shows the relationship between the residual amount of a chemical | medical solution and storage days from the regression line based on the said test result is shown in FIG.5 (b). The horizontal axis of FIG.5 (b) is a preservation | save day (unit: day), and a vertical axis | shaft is the residual amount (unit: mg) of a chemical | medical solution. In a sealed container made of silica-deposited PET film, the chemical solution stored at 400 mg at the start of the test becomes 300 mg or less within one year after storage in the absence of a humidifying material, and is about 160 mg, which is less than half the amount after two years after storage. However, it was found that in the presence of a humidifying material, 350 mg or more was maintained even after 2 years of storage. Further, in a sealed container made of an aluminum foil laminate film, 380 mg was maintained even after 3 years of storage, and it was shown that the storage device of the present invention can store a chemical solution for a long time while protecting it from drying.

(4) Absorption performance of the nonwoven fabric constituting the outer layer of the bag body In the present invention, when water droplets or condensation occurs in the sealed container, it is preferable that water droplets or the like are absorbed by the nonwoven fabric on the surface of the bag body. Therefore, a bag was formed from a plurality of types of non-woven fabrics, and experiments were conducted on their absorption performance. First, using a laminated nonwoven fabric obtained by laminating a 15 micron polyethylene film and a rayon nonwoven fabric having a basis weight of 17 g / m ² , a bag body having a size of 5 cm × 5 cm, in which an inner layer is made of a polyethylene film and an outer layer is made of a rayon nonwoven fabric, was prepared. . In this test, nothing was put in the bag. Next, in a closed container (produced by Nihon Co., Ltd., product name: Rami Zip LZ-D, width 8.5 cm × chuck length 12 cm) made of a transparent two-layer film having a film structure of nylon 15 μm / PE 60 μm, 1 mL Distilled water was added, the bag prepared as described above was accommodated, and the zipper was fastened and sealed. This container was preserve | saved on room temperature conditions, and the bag body was taken out from the airtight container 24 hours after the storage start, the weight was measured, and the water absorption amount of the bag body was measured (test section 1). The test was performed with N number = 2. In addition, a 15 micron polyethylene film and a 20 g / m ² rayon nonwoven fabric (test group 2), a 15 micron polyethylene film and a 25 g / m ² rayon nonwoven fabric (test group 3), 15 micron polyethylene were tested in the same manner. About film and rayon nonwoven fabric with a basis weight of 30 g / m ² (test section 4), spunbond nonwoven fabric (product of Asahi Kasei Fibers Co., Ltd., Ertas PU5020) made of 15 micron polyethylene film and nylon, polyester and polypropylene fibers (test section 5) went. Table 10 shows numerical values of the water absorption amount of the nonwoven fabric on the surface of each bag obtained by the measurement.

  From the test results of (4) above, it was shown that the nonwoven fabric constituting the outer layer of the bag body can absorb water droplets and the like generated in the sealed container and can retain a certain amount of moisture. Moreover, it was shown that the rayon nonwoven fabric is excellent in water absorption and can be used suitably especially as a nonwoven fabric. Thus, the water | moisture content hold | maintained at the outer layer of the bag body is rapidly discharge | released in an airtight container according to the change of the humidity environment in an airtight container, and the humidity in an airtight container can be kept constant.

  The present invention is not limited to the above-described embodiments and examples, but includes various modified designs within the technical scope without departing from the gist of the invention described in the claims. .

DESCRIPTION OF SYMBOLS 1 Storage device 2 Sealed container 21 Chuck 3 Chemical solution container 30 Chemical solution 4 Humidifier 40 Sheet 40a Inner layer 40b Outer layer 41 Welding part 42 Bag body 43 Inclusion

Claims (7)

  An airtight container, at least one chemical solution container accommodated in the airtight container, and a humidifying material accommodated in the airtight container, wherein the humidifying material is constituted by a bag body containing at least water, The bag body includes an inner layer made of a synthetic resin film and an outer layer made of a non-woven fabric.   The said bag body consists of a laminated body formed by bonding a synthetic resin film to a nonwoven fabric, The chemical | medical solution storage apparatus of Claim 1 characterized by the above-mentioned.   The chemical solution storage device according to claim 1, wherein the nonwoven fabric is made of a water-absorbing material.   The medical solution storage device according to any one of claims 1 to 3, wherein the bag body further contains an antibacterial agent.   5. The chemical solution storage container according to claim 1, wherein the chemical solution is stored in the chemical solution storage container, the chemical solution storage container containing the chemical solution and the humidifying material are stored in a sealed container, and the sealed container A method for preserving a chemical solution, characterized by sealing.   The method for storing a chemical solution according to claim 5, wherein the amount of water in the humidifying material is adjusted so that the humidifying material contains water until a desired storage period. Adjustment of the amount of water is
A test water bag containing a predetermined amount of water inside the bag body is previously stored in a test container made of substantially the same material as the sealed container, and the test water bag is sealed after the test container is sealed. Measure the change in the amount of water contained in the
Calculate the amount of water decrease in the test water bag in the closed container until the desired storage period,
The method for storing a chemical solution according to claim 6, wherein the method is performed by setting the amount of water contained in the humidifying material to be equal to or greater than the calculated reduction amount of water.

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