JP5913549B2 - Powder compression molding machine - Google Patents

Description

  The present invention relates to a powder compression molding machine for compressing powder to form pharmaceutical tablets, foods, electronic parts and the like.

  A mortar hole is provided in the rotating disk, and the upper and lower ridges are slidably held on the upper and lower sides of each mortar hole, and both the rotating disk and the ridge are horizontally rotated. A rotary powder compression molding machine that compresses and molds powder filled in a mortar when passing between lower rolls is known (for example, see Patent Document 1 below).

  When manufacturing a product with sugar coating or other coating on the inner core (core tablet), the powder is first compressed by a powder compression molding machine to form the inner core, and then the inner core is a powder compression molding machine. It was customary to carry the coating process into another machine such as a spray coater or pan coater. However, in such a case, it is unavoidable to install a plurality of machines at the manufacturing site, and a process for carrying the inner core carried out from the powder compression molding machine into a spray coater or the like is also required.

JP 2010-023083 A

An object of the present invention is to make it possible to manufacture a product in which a plurality of inner cores are laminated by a powder compression molding machine itself.

In the present invention, a table provided with a mortar hole penetrating vertically, a lower arm placed below the mortar hole and having an upper end inserted into the mortar hole and slidable in the mortar hole, An upper punch, which is disposed above the mortar so as to face the pestle and whose lower end is inserted into the mortar and is slidable in the mortar, and slides before filling the mortar with powder. A first injection device that injects a powder into the mortar, toward the lower end surface of the upper punch and the upper end surface of the lower punch, and after the lubricant is injected by the first injection device A filling device for filling powder into the mortar and a powder filling material by the previous filling device and compression molding with the upper and lower irons, And a second injection device that injects toward the lower end surface of the upper lid, and after the lubricant is injected by the second injection device, To constitute a powder compression molding machine provided with the final filling device for filling the powder is compacted by the lower punch within the die hole. Here, the powder refers to an aggregate of fine solids, and includes so-called granules and powders having a shape smaller than the granules.

Further, a table provided with a mortar hole penetrating vertically, a lower arm that is disposed below the mortar hole, an upper end of which is inserted into the mortar hole and is slidable in the mortar hole, and the lower arm An upper punch, which is disposed above the mortar so as to face each other and whose lower end is inserted into the mortar and is slidable in the mortar, and a powder which is compression-molded by the upper and lower folds The previous filling device for filling the mortar hole, the final filling device for filling the mortar hole with the powder compressed by the upper and lower irons, and the filling by the previous filling device were performed. And a third injection device for injecting a partitioning agent that separates the powder filled by the previous filling device and the powder filled by the last filling device toward the lower end surface of the upper plate. It may be a powder compression molding machine .

  In addition, after the injection by the first injection device, before the injection by the second injection device, the powder compression-molded by the upper punch and the lower punch is put in the mortar hole. If it is provided with a previous filling device to be filled and the second jetting device jets a lubricant, an inner core formed by compressing the powder filled by the previous filling device, and a final filling device A product having a structure in which an inner core formed by compressing a filled powder can be manufactured with only one powder compression molding machine. Note that the powder filled by the previous filling device (being the inner core of the lower layer) and the powder filled by the last filling device (being the inner core of the upper layer) may be of the same type or different types. It may be.

  After the filling by the previous filling device and before the injection by the second injection device, the powder filled by the previous filling device and the powder filled by the last filling device It is also preferable to include a third injection device that injects a partitioning agent that isolates the liquid into the mortar.

The partitioning agent is, for example, a binding agent that connects the inner core of the upper layer and the inner core of the lower layer in an inseparable manner, or a dividing agent that can separate the inner core of the upper layer from the inner core of the lower layer. Further, the partition agent, the partition agent of the upper layer and the lower layer and binding agent for inseparably connecting, or is preferably a device loading agent linked to separate the upper and lower layers of the partition agent. In addition, it is preferable to include a plurality of the third injection devices.

In addition, using the powder compression molding machine according to the present invention , the lubricant is applied to the inner surface of the mortar and the upper end surface of the lower punch by spraying the lubricant into the mortar provided in the table, In addition, a step of applying the lubricant to the lower end surface of the upper punch by spraying the lubricant toward the lower end surface of the upper punch, a step of filling the powder into the mortar, and thereafter The step of compressing the powder with an upper punch and a lower punch, and then applying the lubricant to the inner surface of the mortar by injecting the lubricant into the mortar, and the lower end surface of the upper punch A step of applying a lubricant to the lower end surface of the upper punch by spraying the lubricant toward the top, a step of filling the mortar with further powder, and a filling into the mortar thereafter by performing the step of compressing the by powder the upper punch and the lower punch, and the product of the multilayer structure It can be produced.

Further, using the powder compression molding machine according to the present invention, filling the powder into the mortar, spraying the partitioning agent on the lower end surface of the upper punch, the upper punch coated with the partitioning agent and A step of compressing the powder with a lower punch, a step of further filling the powder on the partitioning agent in the mortar, and a compressing the powder filled in the mortar with an upper punch and a lower punch By carrying out the steps, it is possible to manufacture a product having a laminated structure in which a partitioning agent is interposed.

In addition, using the powder compression molding machine according to the present invention, a lubricant is applied to the inner surface of the mortar and the upper end surface of the lower punch by spraying the lubricant into the mortar, and the mortar Filling the powder in the holes, spraying a partitioning agent toward the lower end surface of the upper punch, compressing the powder using the upper punch coated with the partitioning agent, Applying the lubricant to the lower end surface of the upper punch by spraying the lubricant toward the lower end surface of the upper punch, filling the powder in the mortar, and in the mortar By performing the step of compressing the filled powder with the upper and lower irons, a product having a laminated structure in which a partitioning agent is interposed can be produced.

According to the present invention, a product in which a plurality of layers of inner cores are laminated can be manufactured by the powder compression molding machine itself.

1 is a side sectional view showing a powder compression molding machine according to an embodiment of the present invention. The principal part top view of the powder compression molding machine of the embodiment. The cylindrical view which shows the relationship between the ridge and the roll in the powder compression molding machine of the embodiment. The principal part enlarged plan view which shows the injection apparatus in the powder compression molding machine of the embodiment. The principal part sectional side view which shows the injection apparatus in the powder compression molding machine of the embodiment. The figure which shows the tableting process of the product by the powder compression molding machine of the embodiment. The principal part top view of the powder compression molding machine of one Embodiment of this invention. The figure which shows the tableting process of the product by the powder compression molding machine of the embodiment. The principal part top view of the powder compression molding machine of one Embodiment of this invention. The figure which shows the tableting process of the product by the powder compression molding machine of the embodiment. The figure which shows the tableting process of the product by the powder compression molding machine of one Embodiment of this invention.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings.

  <First Embodiment> The powder compression molding machine according to the first embodiment is a rotary type that produces a product in which an inner core formed by compressing powder is coated with a coating agent. When the product is a tablet, the powder is a powder containing an active ingredient or a powder containing an active ingredient and an excipient.

  First, the overall outline of the rotary powder compression molding machine will be described. As shown in FIG. 1, in a frame 1 of a rotary powder compression molding machine, a vertical shaft 2 serving as a rotating shaft is established, and a rotating disk 3 is attached to the upper portion of the vertical shaft 2 via a connecting portion 21. ing.

  The turntable 3 rotates horizontally, that is, rotates around the vertical shaft 2. The turntable 3 includes a table (mortar disk) 31, an upper punch holder 32, and a lower punch holder 33. As shown in FIG. 2, the table 31 has a substantially disk shape, and a plurality of mortar holes 4 are provided at predetermined intervals along the rotation direction on the outer periphery thereof. The mortar hole 4 penetrates the table 31 in the vertical direction. The table 31 may be divided into a plurality of plates. Further, the mortar hole 4 is not directly formed in the table 31 itself, but a plurality of mortar members which are separate from the table 31 and can be attached to and detached from the table 31 are attached to the table 31, A configuration in which a mortar hole penetrating in the vertical direction is also provided.

  Above and below each mortar 4, an upper heel holding portion 32 and a lower heel holding portion 33 are provided so that the upper heel 5 and the lower heel 6 can be individually slid in the vertical direction with respect to the mortar 4. And hold it. The tip 53 of the upper arm 5 enters and exits the mortar hole 4. The tip 63 of the lower punch 6 is always inserted into the mortar hole 4. The upper rod 5 and the lower rod 6 rotate together with the rotating disk 3 around the vertical shaft 2, that is, revolve.

  A worm wheel 7 is attached to the lower end side of the vertical shaft 2. A worm gear 10 meshes with the worm wheel 7. The worm gear 10 is fixed to a gear shaft 9 that is driven by a motor 8. The driving force output from the motor 8 is transmitted to the gear shaft 9 by the belt 11, and rotationally drives the vertical shaft 2, and thus the rotating disk 3 and the eaves 5 and 6 via the worm gear 10 and the worm wheel 7.

  As shown in FIGS. 2 and 3, on the revolving track around the vertical shaft 2 of the eaves 5 and 6, the preload upper roll 12 and the preload lowering paired up and down with the eaves 5 and 6 interposed therebetween. There are a roll 13, a main roll 14 and a main roll 15. The pre-loading roll 12 and the pre-loading roll 13, and the main-pressing roll 14 and the main-pressing roll 15 are arranged so as to compress the powder filled in the mortar hole 4 from above and below with the tip surfaces of the tips 53 and 63. The two cages 5 and 6 are urged in a direction to approach each other.

  The upper rod 5 and the lower rod 6 have head portions 51 and 61 pressed by the rolls 12, 13, 14, and 15, and shaft portions 52 and 62 having a smaller diameter than the head portions 51 and 61, respectively. The tip portions of the shaft portions 52 and 62 are thinner than other portions so as to be inserted into the mortar hole 4 and have a diameter substantially equal to the inner diameter of the mortar hole 4. The rolls 12, 13, 14, and 15 approach the heads 51 and 61 of the saddles 5 and 6 due to the revolution of the saddles 5 and 6, and come into contact with the heads 51 and 61. Furthermore, the rolls 12, 13, 14, and 15 are displaced horizontally while rolling on the heads 51 and 61, and at that time, the upper collar 5 is pushed downward or the lower collar 6 is pushed upward. During the period when the rolls 12, 13, 14, 15 are in contact with the flat surfaces on the ridges 5, 6, the ridges 5, 6 continue to apply a certain pressure to the powder in the mortar 4.

  A product discharge unit 16 is configured at a position advanced from the pressurization position by the main roll 14 and the main roll 15 along the rotation direction of the rotary plate 3 and the eaves 5 and 6. In the product discharge section 16, the lower punch 6 is raised until the upper end surface of the tip 63 of the lower punch 6 becomes substantially the same height as the upper end of the die hole 4, that is, the upper surface of the table 31, and the molded product in the die hole 4 is removed. Extrude from mortar 4 A guide member 17 for guiding the molded product pushed out from the mortar hole 4 is installed in the product discharge portion 16. The molded product that has exited the mortar hole 4 comes into contact with the guide member 17 by the rotation of the turntable 3, and moves along the guide member 17 toward the molded product collection position 18.

  Next, the filling device X (Xa, Xb) and the injection device Y (Ya, Yb, Yc) in the rotary powder compression molding machine will be described.

  The filling device X is for filling powder into the mortar hole 4, and includes a powder supply mechanism X1, a feed shoe X2, and a grinding plate X3. The powder supply mechanism X1 guides the powder onto the rotation path of the mortar hole 4. The feed shoe X2 drops and fills the powder supplied by the powder supply mechanism X1 into the mortar hole 4 as the lower punch 6 descends to a predetermined height position. After the powder filling by the feed shoe X2, the grinding plate X3 grinds the powder that overflows from the mortar hole 4 by the ascending of the lower punch 6, and removes it from the mortar hole 4.

  The injection device Y sprays a powder propellant other than powder onto the inner peripheral surface of the mortar hole 4, the upper end surface of the tip 63 of the lower punch 6, and the lower end surface of the tip 53 of the upper punch 5. . As shown in FIG. 4, the injection device Y guides the propellant supplied from an external propellant supply device (not shown) and injects it toward the upper end surface of the pestle 63 and the tip 63 of the lower punch 6. Downward injection nozzle Y1, upward injection nozzle Y2 that guides the propellant supplied from the propellant supply device and injects it toward the lower end surface of the tip 53 of the upper punch 5, the tip of the mortar 4 and the tips 5 and 6 The surplus propellant that has not adhered to 53, 63 is sucked and discharged to the outside (may be returned to the propellant supply device), as well as the suction duct Y3 for purging, and these downward jet nozzles Y1, upper The case Y4 that holds the direction injection nozzle Y2 and the suction duct Y3 is used as an element.

  As shown in FIG. 5, the downward injection nozzle Y1 has a flow pipe Y11 extending substantially horizontally in a block made of a fluororesin (particularly polytetrafluoroethylene), and the end of the flow pipe Y11 is bent downward. In this way, an injection port Y12 opened on the lower surface of the block is formed. The inner surfaces of the flow pipe Y11 and the injection port Y12 become a smooth surface of a fluororesin, and smoothes the flow and ejection of the propellant. A static electricity generating electrode Y13 is embedded in the downward spray nozzle Y1. The tip of the static electricity generation electrode Y13 has a needle shape or a taper shape, and protrudes to a location in the vicinity of the injection port Y12. For example, a high direct current voltage of about −20 kV is applied to the static electricity generating electrode Y13, and the propellant immediately before jetting is forcibly electrostatically charged by the electric field concentrated on the tip.

  The upward injection nozzle Y2 has a structure just like the downward injection nozzle Y1 shown in FIG. That is, the upward injection nozzle Y2 is formed by piercing a flow pipe extending substantially horizontally in a block made of a fluororesin, and forming an injection port Y22 opened at the upper surface of the block by curving the end of the flow pipe upward. It is. An electrostatic generation electrode is also embedded in the upward injection nozzle Y2. The tip of the static electricity generating electrode has a needle shape or a taper shape, and protrudes to a location near the injection port Y22.

  The suction duct Y3 is at a height position facing the side of the tip 53 of the upper collar 5. The opening of the suction duct Y3 is fixed to the case Y4 and communicates with the internal space of the case Y4.

  The case Y4 is a fluororesin box that substantially covers the downward injection nozzle Y1 and the upward injection nozzle Y2 in order to prevent disordered release of the propellant. The case Y4 is electrically insulated from the turntable 3 and the injection nozzles Y1 and Y2. The case Y4 is provided with an air curtain Y41 for blowing compressed air substantially horizontally toward the opening of the suction duct Y3. The air curtain Y41 creates an air flow in the vicinity of the tip 53 of the upper rod 5, and prevents upward spraying of the propellant injected from the upward injection nozzle Y2 toward the tip 53 of the upper rod 5.

  The external propellant supply device is a μR feeder (Nisshin Engineering Co., Ltd.) that takes out the propellant accurately and stably little by little through a narrow groove filling type roll and feeds it on pressurized air. Name).

  The propellant supplied from the propellant supply device is divided into the downward injection nozzle Y1 and the upward injection nozzle Y2, flows through the flow pipes in the nozzles Y1 and Y2, and is injected from the injection ports Y12 and Y22. During the injection, the propellant is forcibly electrostatically charged. On the other hand, the mortar hole 4 and the ridges 5 and 6 are grounded through the grounding of the rotating disk 3, and the electrostatically charged propellant is an inner peripheral surface of the mortar hole 4, which is a metal surface, and the tip of the lower ridge 6. It strongly adsorbs to the upper end surface of 63 and the lower end surface of the tip 53 of the upper collar 5. The adsorbed propellant does not peel off due to the vibration of the vertical movement of the punches 5 and 6 and the wind pressure due to the high-speed rotation of the rotating disk 3, and is strongly pressed against the compressed tablet at the same time as the compression compression of the powder by the punches 5 and 6. Dislocation adheres to the tablet from the pestle 53 and 63 of the mortar 4 and the ridges 5 and 6.

  Therefore, in this embodiment, as shown in FIG. 2, a plurality of injection devices Y are provided, and the first injection device Ya, the second injection device Yb, the filling device Xa, the preload roll 12, 13, main rolls 14 and 15, and product discharge unit 16 are arranged in this order along the rotation direction of the rotating disk 3. Then, the lubricant K is injected as the propellant from the first injection device Ya, and the coating agent L is injected as the propellant from the second injection device Yb.

  Lubricant K injected by the first injection device Ya includes a binding where the powder M is fixed to the inner periphery of the mortar hole 4, and sticking where the powder M is fixed to the tips 53 and 63 of the ridges 5 and 6. All of them are for preventing the product from being scratched, roughened or chipped. Examples of the lubricant K include a stearic acid metal salt (particularly magnesium stearate), talc and the like.

  The coating agent L sprayed by the second spraying device Yb is for coating the outer surface of the product. Examples of the coating agent L include sucrose (sugar coating), an enteric polymer (acidic insoluble material), a water-soluble polymer, and the like.

  The manufacturing process of the product using the rotary powder compression molding machine of this embodiment is as follows. First, as shown in FIG. 6 (I), the first injection device Ya has the inner peripheral surface of the mortar hole 4 passing through the vicinity, the upper end surface of the tip 63 of the lower punch 6, and the tip of the upper punch 5. Lubricant K is sprayed onto the lower end surface of 53 and applied. Next, as shown in FIG. 6 (II), the second injection device Yb has the inner peripheral surface of the mortar hole 4 passing through the vicinity, the upper end surface of the tip 63 of the lower punch 6 and the tip of the upper punch 5. The coating agent L is sprayed and applied to the lower end surface of the layer 53 so as to overlap the lubricant K. Then, as shown in FIG. 6 (III), the filling apparatus Xa fills the mortar hole 4 passing through the vicinity with the powder M. Thereafter, as shown in FIG. 6 (IV), the upper punch 5 and the lower punch 6 are pressed against the preloading rolls 12 and 13 to precompress the powder M in the mortar hole 4 and further to the main pressing rolls 14 and 15. To compress the powder M in the mortar hole 4. Thereby, a product in which the outer surface of the inner core obtained by compressing the powder M is coated with the coating agent L is completed.

  According to the present embodiment, the mortar hole 4 penetrating vertically is disposed on the outer peripheral portion, and is disposed below the mortar hole 4 and rotates together with the rotatory disk 3, and the upper end portion is the mortar hole 4. A lower punch 6 that is inserted in the mortar hole 4 and is slidable in the mortar hole 4, and is disposed above the mortar hole 4 so as to face the lower punch 6, rotates together with the rotating disk 3, and has a lower end portion of the mortar. An upper punch 5 that is inserted into the hole 4 and is slidable in the mortar hole 4, and is compression-molded by the upper punch 5 and the lower punch 6 at a predetermined position near the rotational track of the mortar hole 4. A first injection device Ya for injecting a lubricant K, which is a propellant other than the powder M, into the mortar hole 4; and a predetermined position near the rotational trajectory of the mortar hole 4; Coin which is a propellant other than the powder M and is different from the propellant after being injected by the injection device Ya A second injection device Yb for injecting the agent L into the mortar hole 4 and a predetermined position in the vicinity of the rotational trajectory of the mortar hole 4 after the injection by the second injection device Yb is performed. Since the rotary powder compression molding machine including the final filling device Xa for filling the powder M compressed by the upper punch 5 and the lower punch 6 into the mortar hole 4 is configured, Sticking to the inner surface of the mortar 4, the upper end surface of the lower punch 6 and the lower end surface of the upper punch 5 can be effectively suppressed. A product in which the inner core formed by compressing the powder M is coated with the coating agent L can be manufactured with only one powder compression molding machine.

  That is, if the rotary powder compression molding machine according to the present embodiment is used, the lubricant K is injected into the mortar hole 4 provided in the rotating disk 3 to thereby form the inner surface of the mortar hole 4 and the lower punch 6. Lubricant K is applied to the lower end surface of the upper bowl 5 by applying the lubricant K to the upper end face and spraying the lubricant K toward the lower end face of the upper bowl 5 that rotates together with the rotating disk 4. Applying the coating agent L over the lubricant K on the inner surface of the mortar 4 and the upper end surface of the lower punch 6 by spraying the coating agent L into the mortar hole 4; A step of applying the coating agent L over the lubricant K onto the lower end surface of the upper punch 5 by spraying the coating agent L toward the lower end surface of the upper punch 5; The step of filling M, and the powder M filled in the mortar hole 4 is compressed by the upper punch 5 and the lower punch 6 That by the steps performed, it can produce coated products.

  <Second Embodiment> A powder compression molding machine according to a second embodiment manufactures a product having a structure in which a plurality of inner cores formed by compressing powder are laminated. Hereinafter, the difference from the first embodiment will be described with emphasis. The description of the configuration common to the first embodiment is omitted.

  In the present embodiment, as shown in FIG. 7, a plurality of injection devices Y and filling devices X are provided, and the first injection device Ya, the previous filling device Xa, the preload rolls 12 and 13, The second injection device Yb, the last filling device Xb, the main pressure rolls 14 and 15, and the product discharge unit 16 are arranged in this order along the rotation direction of the rotating disk 3.

  Each of the first injection device Ya and the second injection device Yb uses the lubricant K as a propellant, the upper end surface of the tip 63 of the mortar hole 4 and the lower punch 6, and the lower end surface of the tip 53 of the upper punch 5. Inject toward

  The previous filling device Xa fills the mortar hole 4 with the powder M that forms the lower inner core of the product. On the other hand, the last filling device Xb fills the mortar hole 4 with the powder N forming the inner core of the upper layer of the product. The powder M filled in the previous filling device Xa and the powder N filled in the last filling device Xb may be of the same type or different types.

  The manufacturing process of the product using the rotary powder compression molding machine of this embodiment is as follows. First, as shown in FIG. 8 (I), the first injection device Ya has the inner peripheral surface of the mortar hole 4 passing through the vicinity, the upper end surface of the tip 63 of the lower punch 6, and the tip of the upper punch 5. Lubricant K is sprayed onto the lower end surface of 53 and applied. Next, as shown in FIG. 8 (II), the previous filling device Xa fills the mortar hole 4 passing through the vicinity with the powder M. Thereafter, as shown in FIG. 8 (III), the upper punch 5 and the lower punch 6 are pressed by the preloading rolls 12 and 13 to precompress the powder M in the mortar hole 4 and form the inner core of the lower layer.

  Subsequently, as shown in FIG. 8 (IV), the second injection device Yb causes the inner peripheral surface of the mortar hole 4 passing through the vicinity, the upper surface of the compressed powder M, and the tip 53 of the upper punch 5. Lubricant K is sprayed again on the lower end surface of the coating. Then, as shown in FIG. 8 (V), the last filling device Xb fills the mortar hole 4 passing through the vicinity with the powder N. After that, as shown in FIG. 8 (VI), the upper punch 5 and the lower punch 6 are pressed by the main pressure rolls 14 and 15 and the powders M and N in the mortar 4 are finally compressed, and the upper core is formed. Mold. Thereby, a product having a structure in which a plurality of inner cores obtained by compressing the powders M and N is laminated is completed.

  According to the present embodiment, the mortar hole 4 penetrating vertically is disposed on the outer peripheral portion, and is disposed below the mortar hole 4 and rotates together with the rotatory disk 3, and the upper end portion is the mortar hole 4. A lower punch 6 that is inserted in the mortar hole 4 and is slidable in the mortar hole 4, and is disposed above the mortar hole 4 so as to face the lower punch 6, rotates together with the rotating disk 3, and has a lower end portion of the mortar. An upper punch 5 that is inserted into the hole 4 and is slidable in the mortar hole 4, and is compression-molded by the upper punch 5 and the lower punch 6 at a predetermined position near the rotational track of the mortar hole 4. A first injection device Ya for injecting lubricant K, which is a propellant other than the powders M and N, into the mortar hole 4; and a predetermined position near the rotational trajectory of the mortar hole 4; After the injection by the first injection device Ya and before the injection by the second injection device Yb, the upper rod 5 and the lower rod 6 The filling device Xa that fills the mortar hole 4 with the powder M to be compression-compressed, and the injection by the first injection device Ya is performed at a predetermined position near the rotational trajectory of the mortar hole 4. A second injection device Yb for injecting the same lubricant K as that injected by the first injection device Ya into the mortar hole 4, and a predetermined vicinity in the vicinity of the rotational trajectory of the mortar hole 4. The final filling device that fills the mortar hole 4 with the powder N that is compression-molded by the upper punch 5 and the lower punch 6 after being sprayed by the second spraying device Yb. Since the rotary powder compression molding machine provided with Xb is configured, sticking to the inner surfaces of the mortar holes 4 of the powders M and N, the upper end surface of the lower punch 6 and the lower end surface of the upper punch 5 can be effectively suppressed. A product having a structure in which inner cores formed by compressing powders M and N are laminated can be manufactured with only one powder compression molding machine.

  That is, if the rotary powder compression molding machine according to the present embodiment is used, the lubricant K is sprayed into the mortar hole provided in the rotating disk 3 so that the upper surface of the mortar 3 and the lower punch 6 are A step of applying a lubricant K to the end surface, a step of filling powder M in the mortar hole 4, and a lubricant K spraying into the mortar hole 4, thereby sliding the inner surface of the mortar hole 4. Applying the lubricant K, and applying the lubricant K to the lower end surface of the upper punch 5 by spraying the lubricant K toward the lower end surface of the upper punch 5 rotating together with the rotating plate 3; The step of further filling the mortar hole 4 with powder N and the step of compressing the powders M and N filled in the mortar hole 4 with the upper punch 5 and the lower punch 6 are performed. A product having a multi-layered laminated structure can be manufactured.

  In the above-described embodiment, the powder M serving as the inner core of the lower layer filled in the die hole 4 by the previous filling device Xa is preliminarily compressed, and then the last filling device Xb is placed in the upper layer in the die hole 4. The powder N serving as the inner core is filled, but the lower core is not preliminarily compressed, and the upper filling 5 and the lower bowl are filled after the last filling device Xb has filled the powder N serving as the upper core. 6 may be used to compress the lower and upper inner cores together. In that case, the first injection device Ya, the previous filling device Xa, the second injection device Yb, the last filling device Xb, the preloading rolls 12 and 13, the main pressure rolls 14 and 15, and the product discharge unit 16 They are arranged in this order along the direction of rotation of the turntable 3. Since no preliminary compression of the inner core of the lower layer is performed, it is not necessary for the second injection device Yb to re-apply the lubricant K to the lower end surface of the tip 53 of the upper punch 5, and thus the second injection device Yb. Is not provided with the upward injection nozzle Y2.

  It is also conceivable that three or more injection devices Y and filling devices X are arranged along the rotation path of the mortar hole 4 to manufacture a product having a multilayer structure of three or more layers.

  Combining the configuration of the second embodiment with the configuration of the first embodiment makes it possible to manufacture a product that is also coated in addition to the structure in which the inner cores are stacked.

  <Third Embodiment> The powder compression molding machine of the third embodiment also manufactures a product having a structure in which a plurality of inner cores formed by compressing powder are laminated. Hereinafter, the difference from the second embodiment will be described with emphasis. The description of the configuration common to the second embodiment or the first embodiment is omitted.

  In the present embodiment, as shown in FIG. 9, a plurality of injection devices Y and filling devices X are provided, and the first injection device Ya, the previous filling device Xa, the preload rolls 12 and 13, The third injection device Yc, the second injection device Yb, the last filling device Xb, the main pressure rolls 14 and 15, and the product discharge unit 16 are arranged in this order along the rotation direction of the turntable 3.

  Each of the first injection device Ya and the second injection device Yb uses the lubricant K as a propellant, the upper end surface of the tip 63 of the mortar hole 4 and the lower punch 6, and the lower end surface of the tip 53 of the upper punch 5. Inject toward

  The third injection device Yc injects the partitioning agent O as a propellant toward the inside of the mortar hole 4 (the upper surface of the compressed powder M). The partitioning agent O separates the powder M filled by the previous filling device Xa from the powder N filled by the last filling device Xb. Examples of the partitioning agent O include a binding agent that connects the upper inner core and the lower inner core inseparably, and a dividing agent that enables the upper inner core and the lower inner core to be separated. The partitioning agent O is not applied to the lower end surface of the tip 53 of the upper collar 5. Therefore, the third injection device Yc is not provided with the upward injection nozzle Y2.

  The previous filling device Xa fills the mortar hole 4 with the powder M that forms the lower inner core of the product. On the other hand, the last filling device Xb fills the mortar hole 4 with the powder N forming the inner core of the upper layer of the product. The powder M filled in the previous filling device Xa and the powder N filled in the last filling device Xb may be of the same type or different types.

  The manufacturing process of the product using the rotary powder compression molding machine of this embodiment is as follows. First, as shown in FIG. 10 (I), the first injection device Ya has the inner peripheral surface of the mortar hole 4 passing through the vicinity, the upper end surface of the tip 63 of the lower punch 6 and the tip of the upper punch 5. Lubricant K is sprayed onto the lower end surface of 53 and applied. Next, as shown in FIG. 10 (II), the previous filling device Xa fills the mortar hole 4 passing through the vicinity with the powder M. Thereafter, as shown in FIG. 10 (III), the upper punch 5 and the lower punch 6 are pressed by the pre-loading rolls 12 and 13 to pre-compress the powder M in the mortar hole 4 and form the inner core of the lower layer.

  Subsequently, as shown in FIG. 10 (IV), the third injection device Yc sprays the partitioning agent O into the mortar hole 4 (the upper surface of the compressed powder M) passing through the vicinity, A partitioning agent O is applied on top. Further, as shown in FIG. 10 (V), the second injection device Yb is provided with the inner peripheral surface of the mortar hole 4 passing through the vicinity, the upper surface of the compressed powder M, and the tip 53 of the upper punch 5. Lubricant K is again sprayed and applied to the lower end surface. Then, as shown in FIG. 10 (VI), the last filling device Xb fills the mortar hole 4 passing through the vicinity with the powder N. After that, as shown in FIG. 10 (VII), the upper punch 5 and the lower punch 6 are pressed by the main pressure rolls 14 and 15 and the powders M and N in the mortar 4 are finally compressed, and the upper core is formed. Mold. Thereby, a product having a structure in which a plurality of inner cores obtained by compressing the powders M and N is laminated is completed.

  According to the present embodiment, the mortar hole 4 penetrating vertically is disposed on the outer peripheral portion, and is disposed below the mortar hole 4 and rotates together with the rotatory disk 3, and the upper end portion is the mortar hole 4. A lower punch 6 that is inserted in the mortar hole 4 and is slidable in the mortar hole 4, and is disposed above the mortar hole 4 so as to face the lower punch 6, rotates together with the rotating disk 3, and has a lower end portion of the mortar. An upper punch 5 that is inserted into the hole 4 and is slidable in the mortar hole 4, and is compression-molded by the upper punch 5 and the lower punch 6 at a predetermined position near the rotational track of the mortar hole 4. A first injection device Ya for injecting a lubricant K, which is a propellant other than the powder M, into the mortar hole 4; and a predetermined position near the rotational trajectory of the mortar hole 4; After the injection by the second injection device Ya and before the injection by the second injection device Yb, the upper rod 5 and the lower rod 6 The filling device Xa for filling the powder M to be compacted into the mortar hole 4 and the filling device Xa at a predetermined position near the rotational trajectory of the mortar hole 4 were performed. After that, before the injection by the second injection device Yb is performed, a partitioning agent O which is a propellant other than the powder M compression-molded by the upper punch 5 and the lower punch 6 is put in the mortar hole 4 The third injection device Yc that injects the first injection device Ya and the first injection device Ya after being injected by the first injection device Ya at a predetermined position in the vicinity of the rotational trajectory of the mortar hole 4 A second injection device Yb for injecting the same lubricant K as the injection into the mortar hole 4, and a second injection device Yb at a predetermined position in the vicinity of the rotational trajectory of the mortar hole 4; The powder N to be compression-molded by the upper punch 5 and the lower punch 6 Since the rotary powder compression molding machine including the final filling device Xb for filling the mortar hole 4 is configured, the inner surfaces of the mortar holes 4 of the powders M and N, the upper end surface of the lower punch 6 and the lower surface of the upper punch 5 Sticking to the end face can be effectively suppressed. A product having a structure in which the inner core formed by compressing the powders M and N and the partitioning agent O interposed therebetween can be manufactured with only one powder compression molding machine.

  That is, if the rotary powder compression molding machine according to the present embodiment is used, the lubricant K is injected into the mortar hole 4 provided in the rotating disk 3 to thereby form the inner surface of the mortar hole 4 and the lower punch 6. A step of applying a lubricant K to the upper end surface, a step of filling the pestle 4 with the powder M, and a jetting of the partitioning agent O into the mortar hole 4 to The step of applying the partitioning agent O to the mortar hole 4, the lubricant K is sprayed into the mortar hole 4 to apply the lubricant K to the inner surface of the mortar hole 4, Applying the lubricant K to the lower end surface of the upper punch 5 by spraying the lubricant K toward the lower end surface of the punch 5, filling the powder N further into the mortar hole 4, and A step of compressing the powders M and N filled in the mortar hole 4 with the upper punch 5 and the lower punch 6 to form a multi-layer laminated structure. Capable of producing a product having a.

  In the above-described embodiment, the powder M serving as the inner core of the lower layer filled in the die hole 4 by the previous filling device Xa is preliminarily compressed, and then the last filling device Xb is placed in the upper layer in the die hole 4. The powder N serving as the inner core is filled, but the lower core is not preliminarily compressed, and the upper filling 5 and the lower bowl are filled after the last filling device Xb has filled the powder N serving as the upper core. 6 may be used to compress the lower and upper inner cores together. In that case, the first injection device Ya, the previous filling device Xa, the third injection device Yc, the second injection device Yb, the last filling device Xb, the preload rolls 12 and 13, the main pressure rolls 14 and 15 The product discharge unit 16 is arranged in this order along the rotation direction of the turntable 3. Since no preliminary compression of the inner core of the lower layer is performed, it is not necessary for the second injection device Yb to re-apply the lubricant K to the lower end surface of the tip 53 of the upper punch 5, and thus the second injection device Yb. Is not provided with the upward injection nozzle Y2.

  Two or more injection devices Y for injecting the lubricant K along the rotation path of the mortar 4 are disposed, three or more filling devices X, and two or more injection devices Y for injecting the partitioning agent O are provided. It is also conceivable to manufacture a product having a multilayer structure of more than one layer.

  Instead of injecting the partitioning agent O toward the mortar hole 4 by the third injection device Yc, the partitioning agent O formed in advance in a thin plate shape is placed on the powder M as the inner core of the lower layer. May be.

  Combining the configuration of the third embodiment with the configuration of the first embodiment makes it possible to manufacture a product that is also coated in addition to a structure in which inner cores are stacked.

  <Fourth Embodiment> The powder compression molding machine of the fourth embodiment is a vertical (reciprocating) molding machine and is not a rotary type. Hereinafter, the difference from the first to third embodiments will be described with emphasis. Descriptions of configurations common to the first to third embodiments are omitted.

  The powder compression molding machine of the present embodiment also has a table 31 provided with a mortar hole 4 penetrating vertically and an injection device Y (Ya, Ya, which injects propellants K, L, O into the mortar hole 4. Yb, Yc), filling device X (Xa, Xb) for filling powder M, N in the mortar hole 4, and lower punch 6 for compressing the powder M, N filled in the mortar hole 4 from above and below And a pair of upper collars 5.

  In the vertical molding machine, the table 31, the lower rod 6 and the upper rod 5 do not rotate. Instead, the injection device Y and the filling device X move with respect to the table 31. Each of the pair of the injection device Y, the filling device X, the lower rod 6 and the upper rod 5 is driven by an appropriate driving method such as a cam or hydraulic pressure (hydraulic pressure).

  The basic structures and functions of the injection device Y and the filling device X are the same as or similar to those in the first to third embodiments. That is, the injection device Y injects the propellants K, L, and O supplied from the external propellant supply device toward the upper end surface of the tip 63 of the mortar hole 4 and the lower punch 6, and / or It injects toward the lower end surface of the tip 53 of the heel 5. The filling device X throws the powders M and N into the mortar 4 from directly above the mortar 4.

  The operation of the powder compression molding machine will be described by taking as an example the case of manufacturing a product whose inner core is coated with a coating agent. In this case, the powder compression molding machine includes a first injection device Ya for injecting the lubricant K, a second injection device Yb for injecting the coating agent L, and a filling device Xa for filling the powder M. And are arranged.

The production process of the product using the powder compression molding machine will be described. First, as shown in FIG. 11 (I), the lower iron 6 is lowered to an appropriate height corresponding to the filling amount of the powder M. The first injection device Ya moves to the vicinity of the die hole 4 and slides on the inner peripheral surface of the die hole 4, the upper end surface of the tip 63 of the lower punch 6, and the lower end surface of the tip 53 of the upper punch 5. Spray the powder K and apply. Next, as shown in FIG. 11 (II), the second injection device Yb moves to the vicinity of the mortar hole 4, and the inner peripheral surface of the mortar hole 4, the upper end surface of the tip 63 of the lower punch 6, and the upper punch The coating agent L is sprayed and applied to the lower end surface of the heel 53 of 5 to overlap the lubricant K. Then, as shown in FIG. 11 (III), the filling device Xa moves to the vicinity of the mortar hole 4 and fills the mortar hole 4 with the powder M. Then, as shown in FIG. 11 (IV), the injection devices Ya, Yb and the filling device Xa are retracted to a position where they do not interfere with the tableting operation of the upper punch 5 and the lower punch 6, and the upper punch 5 and the lower punch 6 are moved to the die. The powder M in the hole 4 is compressed. Thereby, a product in which the outer surface of the inner core obtained by compressing the powder M is coated with the coating agent L is completed. After that, the upper rod 5 is raised to a height that does not interfere with the injection devices Ya, Yb and the filling device Xa, and the finished product of the lower rod 6 is pushed up to the upper surface of the table 31 to complete as shown in FIG. Scrape and remove the finished product. The above FIG. 11 (I) to FIG. 11 (V) are repeated.

  In contrast, when manufacturing a product having a structure in which a plurality of inner cores are stacked, at least one lubricant injection device Ya and at least one filling device Xa are arranged in a powder compression molding machine. In the manufacturing process of the product using the powder compression molding machine, (I) spray application of the lubricant K to the inner periphery of the mortar 4 and the tips 53 and 63 of the punches 5 and 6 by the spray device Ya; (II) Filling the mortar 4 with the powder M by the filling device Xa, (III) compressing the inner core of the lower layer with the ridges 5 and 6, and (IV) the inner circumference of the mortar 4 with the injection device Ya and the ridge 5 , 6 again spray application of the lubricant K to the tips 53, 63, (V) filling the mortar 4 again with the filling device Xa, (VI) upper layer by the heels 5, 6 The procedure of compression tableting of the inner core and (VII) carrying out the finished product is taken. If the types of the powders N and M used as raw materials are different between the upper layer and the lower layer, the previous filling device Xa for filling a certain type of powder M in the procedure (II) and the procedure (V ) And the final filling device Xb for filling another type of powder N must be provided separately. Moreover, you may make it arrange | position separately the injection apparatus Ya which injects the lubricant K in the procedure (I), and the injection apparatus Yb which injects the lubricant K in the procedure (IV).

  Furthermore, when manufacturing a product having a structure in which a partitioning agent is interposed between the upper inner core and the lower inner core, the powder compression molding machine includes a lubricant injection device Ya, a partitioning agent injection device Yc, And at least one filling device Xa. In the manufacturing process of the product using the powder compression molding machine, (I) spray application of the lubricant K to the inner periphery of the mortar 4 and the tips 53 and 63 of the punches 5 and 6 by the spray device Ya; (II) Filling the mortar 4 with the powder M by the filling device Xa, (III) Compressing the inner core of the lower layer with the punches 5 and 6, and (IV) The lower inner core in the mortar 4 with the injection device Yc. Spray coating of the partitioning agent O on the top, (V) spray coating of the lubricant K again on the inner periphery of the mortar 4 and the tips 53 and 63 of the punches 5 and 6 by the spraying device Ya, (VI) The procedure of filling the mortar hole 4 again with the filling device Xa, (VII) compressing the inner core of the upper layer with the punches 5 and 6, and (VIII) carrying out the finished product is performed. If the types of the powders N and M used as raw materials are different between the upper layer and the lower layer, the above-mentioned filling apparatus Xa for filling a certain type of powder M in the procedure (II) and the procedure (VI) It is necessary to separately arrange the final filling device Xb for filling another type of powder N. Moreover, you may make it arrange | position separately the injection apparatus Ya which injects the lubricant K in the procedure (I), and the injection apparatus Yb which injects the lubricant K in the procedure (V).

  The present invention is not limited to the embodiments described in detail above. The specific configuration of each part can be variously modified without departing from the spirit of the present invention.

  INDUSTRIAL APPLICATION This invention can be utilized as a powder compression molding machine for compressing powder and manufacturing products, such as a pharmaceutical tablet, a foodstuff, and an electronic component.

31 ... Table 4 ... Mortar hole 5 ... Upper punch 6 ... Lower punch K ... Lubricant L ... Coating agent M, N ... Powder O ... Partitioning agent X ... Filling device Xa ... Previous filling device Xb ... Last filling device Y ... Injection device Ya ... First injection device Yb ... Second injection device Yc ... Third injection device

Claims (7)

A table provided with a mortar hole penetrating vertically;
A lower arm that is disposed below the acetabulum and has an upper end inserted into the acetabulum and slidable within the acetabulum;
An upper arm that is arranged above the mortar so as to face the lower arm, and whose lower end is inserted into the mortar and is slidable in the mortar,
A first injection device that injects a lubricant into the mortar, toward the lower end surface of the upper punch and the upper end surface of the lower punch before filling the powder into the mortar ;
After the lubricant is jetted by the first jetting device, the previous filling device for filling powder into the mortar hole,
The second injection device that injects the lubricant into the mortar and toward the lower end surface of the upper punch after filling the powder with the previous filling device and compression-molding with the upper punch and the lower punch. When,
After the lubricant is jetted by the second jetting device, the final compacting device is provided with a final filling device that fills the mortar hole with the powder that is compression-molded by the upper punch and the lower punch. Molding machine. A table provided with a mortar hole penetrating vertically;
A lower arm that is disposed below the acetabulum and has an upper end inserted into the acetabulum and slidable within the acetabulum;
An upper arm that is arranged above the mortar so as to face the lower arm, and whose lower end is inserted into the mortar and is slidable in the mortar,
A previous filling device that fills the pestle with powder that is compression-molded by the upper and lower eyelids,
A final filling device for filling the mortar with the powder that is compression-molded by the upper and lower eyelids,
A powder comprising a third spraying device that sprays a partitioning agent that separates the powder filled by the previous filling device and the powder filled by the last filling device toward the lower end surface of the upper plate. Body compression molding machine. The powder according to claim 2 , wherein the partitioning agent is a binding agent that connects the upper layer and the lower layer of the partitioning agent inseparably or a dividing agent that connects the upper layer and the lower layer of the partitioning agent so as to be separable. Compression molding machine. The powder compression molding machine according to claim 2 or 3, comprising a plurality of the third injection devices. A method of manufacturing a product that is performed using a powder compression molding machine,
The lubricant is applied to the inner surface of the mortar and the upper end surface of the lower punch by injecting the lubricant into the mortar hole provided on the table, and the lubricant is applied to the lower end surface of the upper punch. A step of applying a lubricant to the lower end surface of the upper eyelid by spraying ;
Then filling the mortar with powder,
Then compressing the powder with upper and lower eyelids;
After that, the lubricant is applied to the inner surface of the mortar by spraying the lubricant into the mortar, and the lubricant is sprayed to the lower surface of the upper punch to Applying a lubricant to the end face;
Then filling the mortar with further powder;
And a step of compressing the powder filled in the mortar with the upper and lower punches. A table provided with a mortar hole penetrating vertically;
A lower arm that is disposed below the acetabulum and has an upper end inserted into the acetabulum and slidable within the acetabulum;
It is carried out using a powder compression molding machine that is arranged above the mortar hole so as to face the lower ridge, and has an upper ridge that is inserted into the mortar hole and is slidable in the mortar hole. A method for manufacturing a product, comprising:
Filling the mortar with powder;
Injecting a partitioning agent onto the lower end surface of the upper bowl;
A step of the partition agent is to compress the powder in the punch and the lower punch on which is applied,
Filling the powder further on the partitioning agent in the mortar,
A method of manufacturing a product having a multi-stage laminated structure, comprising: compressing powder filled in the mortar with an upper punch and a lower punch. A table provided with a mortar hole penetrating vertically;
A lower arm that is disposed below the acetabulum and has an upper end inserted into the acetabulum and slidable within the acetabulum;
It is carried out using a powder compression molding machine that is arranged above the mortar hole so as to face the lower ridge, and has an upper ridge that is inserted into the mortar hole and is slidable in the mortar hole. A method for manufacturing a product, comprising:
Applying a lubricant to the inner surface of the mortar and the upper end surface of the lower arm by spraying the lubricant into the mortar,
Filling the mortar with powder;
A step of injecting a partition agent toward the lower end surface of the upper punch,
Compression-molding the powder using an upper punch coated with the partitioning agent;
Applying the lubricant to the lower end surface of the upper bowl by spraying the lubricant toward the lower end face of the upper bowl; and
Filling the mortar with powder further;
A method of manufacturing a product having a multi-stage laminated structure, comprising: compressing powder filled in the mortar with the upper and lower punches.

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