JP5862550B2 - Gas spray type liquid sample injection device and injection container used therefor - Google Patents

Description

  The present invention relates to a gas spray type sample injection device for injecting a liquid sample into an injection container while spraying a gas on the liquid sample, and an injection container used therefor. This gas spray type liquid sample injection device and injection container are preferably used in a preparative purification device that uses a liquid chromatograph to separate one or more components contained in a solution and then purifies and recovers each component. Can do.

  For example, in the pharmaceutical field or the like, a sample to be stored as a library is collected by a preparative purification apparatus using a liquid chromatograph. In the apparatus described in Patent Document 1, target components (compounds) in a sample solution are temporally separated by liquid chromatography, introduced into different trap columns for each target component, and once collected. Thereafter, a solvent is passed through each trap column to elute components collected in the column, and a solution containing the target component is collected in a container. Thereafter, the solvent is removed, and a solidification process for recovering the target component as a solid is performed.

  The drying process is generally performed by heating the collected solution. However, in this method, the temperature cannot be raised too much in order to avoid alteration of the target component, and depending on the component, it takes a time of several hours to about one day. Since this drying process takes the longest time in the preparative purification process, it is important to reduce the time of the drying process in order to shorten the time of all processes.

  In order to solve the above problems, in Patent Documents 2 to 5, evaporation of the solvent is performed by spraying a gas such as air or nitrogen while dropping a solution containing the target component onto the recovery container, and by atomizing the solution. A method of promoting is disclosed.

A general procedure of the drying process (hereinafter referred to as “gas spraying evaporation / drying process”) by the methods of Patent Documents 2 to 5 will be described with reference to FIG. The preparative purification apparatus of FIG. 7 includes a temperature control block 54 for heating the recovery container 53 to a predetermined temperature, and a solution introduction tube for introducing a solution into the recovery container 53 accommodated in the temperature control block 54. 50 and a seal tube 55 for exhausting the atomized gas introduced into the recovery container 53 and the solvent evaporated in the recovery container 53 so as not to leak out of the apparatus. The solution introduction tube 50 and the seal tube 55 are integrated, and the solution introduction tube 50 has a double tube structure of an inner tube 50A through which the solution flows and an outer tube 50B through which the atomized gas flows. The collection container 53 includes a collection container main body 51 and a lid 52 attached to the upper opening thereof. The lid portion 52 includes a donut-shaped cushion 52A and a cushion placement portion 52B in which a hole is provided in the center for placing the cushion 52A (FIG. 7 (a)) .

In the gas spraying evaporation / drying process, the solution introduction pipe 50 is lowered and inserted into the recovery container 53 through the central hole of the cushion 52A and the cushion mounting portion 52B (FIG. 7B) . Along with this, the seal tube 55 is also lowered, and its tip presses the cushion 52A. As a result, the tip of the seal tube 55 comes into close contact with the cushion 52A, and the space between the collection container 53 and the seal tube 55 is hermetically sealed. Thereafter, the solution is sent to the inner tube 50A and the atomized gas is sent to the outer tube 50B (FIG. 7 (c)) . As a result, the solution dropped from the tip of the inner tube 50A is sheared by the atomized gas flow from the outer tube 50B, and becomes microdroplets (mist) and adheres to the inner wall of the collection container 53. Since the recovery container 53 is preheated by the temperature control block 54, the solvent of the fine droplets adhering to the inner wall evaporates, and only the target component (solute) remains as a powder. The atomized gas introduced into the recovery container 53 and the solvent evaporated in the recovery container 53 are discharged through the seal tube 55.

JP 2003-149217 A International Publication WO2009 / 044445 International Publication WO2009 / 044426 International Publication No. WO2009 / 044427 International Publication WO2009 / 044428

In the preparative purification apparatus as shown in FIG. 7, while the collection container 53 is used many times, plastic deformation occurs in the cushion 52A, and the tip of the seal tube 55 is not properly sealed. In such a case, the cushion 52A has a structure that is simply placed on the cushion placing portion 52B so that the cushion 52A can be easily replaced (FIG. 7 (d)) .

  However, since the lid portion 52 has such a structure, after the above process is completed, the cushion 52A is in close contact with the seal tube 55 while being deformed, and is removed from the cushion placement portion 52B and pulled up together with the seal tube 55. There was a thing. As a result, when the gas blowing type evaporation / drying process is performed in the next recovery container, the next recovery container cannot be properly sealed by the cushion 52A that remains in close contact with the tip of the seal tube 55, and the recovery container Troubles such as leakage of the atomized gas introduced into the inside and the solvent evaporated in the collection container occurred.

  The problem to be solved by the present invention is that a liquid sample is sprayed into a predetermined container (hereinafter referred to as “a”) while atomizing gas is sprayed onto the liquid sample as in the gas spraying evaporation / drying process. An injection container that can be surely sealed so as not to leak the atomized gas introduced into the injection container and the solvent evaporated in the injection container even if the process of injecting into the injection container is carried out continuously. And a gas spray type liquid sample injection device.

The present invention was made in order to solve the above problems includes a sample introduction pipe made of the liquid sample tube and atomizing gas outer tube for supplying atomized liquid body sample, before Symbol sample introduction tube An injection container used in a gas spraying type liquid sample injection device having an exhaust seal pipe provided around ,
a casting container body having an opening in a) top,
b) a lid portion which is mounted in the opening,
c) a cushion housing recess provided in the lid , having an opening at the top and a hole through which the sample introduction tube passes at the bottom ;
d) an annular cushion member having an abutting surface that is accommodated in the cushion accommodating recess and abutted against a lower end of the exhaust seal pipe;
e) a locking portion provided on an inner peripheral side surface of the cushion housing recess for preventing the cushion member from moving upward.

In the injection container for the gas spray type liquid sample injection device according to the present invention, the cushion member is prevented from rising together with the exhaust seal pipe by providing a locking portion that prevents the cushion member from moving up. As a result, even if a process such as a gas spraying evaporation / drying process is continuously performed, the tip of the exhaust seal pipe can be surely pressed against the cushion member for sealing, so that the atomized gas or The evaporated solvent does not leak. Further, the cushion member, since only been locked more with the locking portion, as in the prior art, the replacement of the cushion member can be easily performed.
Particularly in containers used for collecting pharmaceutical samples, there is a tendency to avoid the use of adhesives or the like that may be mixed in the container even as a small amount of impurities. Therefore, an injection container that locks the cushion member without using an adhesive or the like is suitable for a sample collection of such pharmaceuticals and a preparative purification apparatus that is often used for such applications.

The locking portion can be , for example, a threaded cut provided on the inner peripheral side surface. Further, it may be returned or concave convex provided on the inner circumferential side.

In addition, the gas spraying liquid sample injection device according to the present invention, which has been made to solve the above problems, is a gas spraying liquid sample injection that atomizes and supplies a liquid sample into a sample container having an opening at the top. A device,
a) the inner pipe for a liquid sample for feeding the liquid sample, and the sample inlet tube made of atomizing gas outer tube for delivering the gas to atomize the liquid sample,
b) an exhaust seal pipe provided around the sample introduction pipe;
c) a member mounted in the opening, a through hole Ru passed through a sample introduction tube, an annular cushion member the lower end of the exhaust seal pipe having abutting contact surfaces,
d) a member attached to the opening, and a locking member that prevents the cushion member from moving upward when the cushion member is attached to the opening .

The locking member is a lid of the sample container;
It is desirable that the lid has a concave portion for accommodating the cushion member, and has a cushion accommodating concave portion provided on the inner peripheral side surface with a locking portion for preventing the cushion member from moving upward .
Moreover, the the tip of the exhaust seal pipe diameter or less of a thinnest portion of the outer diameter of the through hole, the thickest portion larger tapered peak portion than the diameter of the outer diameter of the through hole is provided in it is desirable to have.
With these configurations, the cushion member is deformed obliquely downward as the exhaust seal pipe is lowered, and at that time, the cushion member enters the engaging portion provided on the inner peripheral side surface of the cushion housing recess . Therefore, the resistance against the movement of the cushion member in the vertical direction is further increased, and the cushion member is more strongly prevented from being detached from the cushion housing recess when the exhaust seal pipe is raised.

The injection container according to the present invention, the upward movement of the cushion member is further prevented the engaging portion provided on the inner peripheral surface of the cushion housing recess. Further, the upward movement of the cushion member is prevented by the locking member in the gas spray type liquid sample injection device according to the present invention. Thus, even if the step of injecting the liquid sample into the injection container while spraying the atomized gas to the liquid sample as in the gas spraying evaporation / drying step is performed continuously, the exhaust seal tube Therefore, the atomized gas and the evaporated solvent are not leaked from between them. Further, since the cushion member is only locked by the locking portion (locking member) , the cushion can be easily replaced as in the conventional case.

The principal part block diagram of the preparative refinement | purification apparatus using the gas spraying-type liquid sample injection device which concerns on one Example of this invention. It is a schematic longitudinal cross-sectional view which shows the structure of the injection container used for the liquid sample introduction apparatus of a present Example, (a) is the whole figure, (b) is a figure which shows each component which comprises an injection container. In the gas sprayed liquid sample injection device of the present embodiment, a schematic longitudinal sectional view (a) showing a state before inserting a sample introduction tube into an injection container, and a schematic longitudinal sectional view showing a state after insertion (b) ). It is a schematic longitudinal sectional view showing a modified example of the exhaust seal tube used in the gas spray type liquid sample injection device of the present embodiment, (a) is the center of the donut-shaped cushion provided on the lid portion of the injection container. The figure which shows the dimension of this exhaust pipe with respect to the diameter of a hole, (b) is a figure which shows the state which lowered | hung this exhaust pipe and inserted in this hole. The schematic longitudinal cross-sectional view which shows the modification of the injection | pouring container used in the gas spraying type liquid sample injection apparatus of a present Example. The schematic longitudinal cross-sectional view which shows another modification of the injection | pouring container used in the gas spraying type liquid sample injection apparatus of a present Example. Explanatory drawing of the powdering process by the conventional fractionation refinement | purification apparatus.

An embodiment of a gas spraying type liquid sample injection device according to the present invention will be described with reference to FIGS. FIG. 1 is a block diagram of a main part of a preparative purification apparatus to which a gas spraying type liquid sample injection device of this embodiment is applied. In this preparative purification device, as described later, a preparative liquid chromatograph (not shown) preliminarily collects a solution containing the target component, but the preparative liquid chromatograph is directly connected to the preparative purification device. Alternatively, the solution separated by the preparative liquid chromatograph can be changed directly into the preparative purification apparatus.
FIG. 2 is a schematic longitudinal sectional view of an injection container used in the gas spraying type liquid sample injection device of the present embodiment. FIG. 3 shows the inside of the injection container in the gas spraying type liquid sample injection device of the present example. It is a schematic longitudinal cross-sectional view which shows the state before and behind inserting a sample introduction tube into.

In FIG. 1, a solution container 1 contains a solution containing a target component, which is preliminarily collected and uses a mobile phase used in a preparative liquid chromatograph as a main solvent. The pure water container 2 contains pure water (H ₂ O), and the elution solvent container 3 contains dichloromethane (DCM). The switching valve 4 switches the flow path so that any one of the liquids stored in these three containers 1, 2, 3 is selectively flowed to the flow path 5. Further, a liquid feed pump 6 is provided on the flow path 5 for sucking and sending the liquid at a predetermined flow rate.

  The outlet end of the flow path 5 is connected to the a port of the switching valve 7. A flow path 10 leading to a trap column 8 filled with an adsorbent for collecting a target component is connected to the b port of the switching valve 7, and an atomizing gas flow path 22 described later is connected to the c port. The flow paths 11 are connected to each other. The switching valve 7 selectively connects the channel 10 or the channel 11 to the channel 5.

  The trap column 8 is erected and held substantially vertically by the column rack 9 with the inlet end to which the flow path 10 is connected right below and the outlet end to which the flow path 12 described later is connected upward. Although only one trap column 8 is shown in FIG. 1, it is also possible to hold a plurality of trap columns 8 side by side in the column rack 9 as shown by dotted lines in FIG.

  The other end of the flow path 12 whose one end is connected to the outlet end of the trap column 8 is connected to the a port of the switching valve 15 built in the sorting head 16, and the flow path 14 is connected to the b port of the switching valve 15. Connected to the c port is a flow path 13 leading to a waste liquid port. The switching valve 15 alternatively connects the flow path 13 or the flow path 14 to the flow path 12.

  The sorting head 16 includes a sample introduction pipe 17 and an exhaust seal pipe 18 integrally provided outside thereof, and can be moved up and down and horizontally by an XYZ drive mechanism 29 including a plurality of motors. Yes. The sample introduction tube 17 includes an inner tube 40 connected to the flow channel 14 and an outer tube 41 connected to the flow channel 22 (note that the sample introduction tube 17 and the injection container 20 in FIG. This configuration is shown in FIG. As will be described later, a solution containing a target component is sent to the inner pipe 40 through the flow path 14, and atomized gas is sent to the outer pipe 41 through the flow path 22.

The injection container 21 into which the solution is injected is individually accommodated in a temperature control block 27 of a container rack 24 to which a heater 25 and a temperature sensor 26 such as a thermistor are attached . The container rack 24 and the temperature control block 27 of the container rack 24 are formed of a material having good heat conductivity such as aluminum, and the outside is covered with a heat insulating material to prevent heat from escaping to the surroundings. (Not shown).

At least the bottom of each injection container 21 is in contact with the upper surface of the temperature control block 27 so that heat from the temperature control block 27 is easily conducted. As a more preferable form, the side peripheral surface of the injection container 21 may be in contact with the inner peripheral surface of the temperature control block 27. Container rack 24 and the temperature control unit 28 provided separately from the monitor temperature detected by the temperature sensor 26 to adjust the heating current supplied to the heater 25 so that the target temperature. As a result, the injection container 21 is maintained at an appropriate constant temperature.

The injection container 21 includes an injection container main body 19 and a lid portion 20 attached to the upper opening thereof. The lid 20 has a cushion housing recess 42 provided with a hole for guiding the sample introduction tube 17 into the injection container body 19 at the center . The cushion accommodating recess 42, a donut-shaped cushion (annular cushion member) 43 is accommodated. As a characteristic structure of the present invention, the cushion housing recess 42 is provided with a threaded cut as an engaging portion 44 on the inner peripheral side surface thereof. Cushion 43, as the outer peripheral side is engaged with the locking portion 4 4, it is housed in the cushion accommodation recess 42 so as to push the locking portion 4 4. The injection container body 19 corresponds to a sample container that supplies a liquid sample using the liquid sample injection apparatus according to the present invention. The lid 20 corresponds to a locking member in the liquid sample injection device according to the present invention.

The sorting head 16 is moved onto an arbitrary container among the plurality of injection containers 21 accommodated in the container rack 24 by the XYZ drive mechanism 29 and lowered. As a result, the sample introduction tube 17 is introduced into the injection container main body 19 through the central hole of the cushion housing recess 42 and the cushion 43. Further, the tip of the exhaust seal pipe 18 presses the upper surface (contact surface) of the cushion 43 , so that the space between the exhaust seal pipe 18 and the injection container 21 is hermetically sealed. In this state, the gas spraying evaporation / drying process described later is performed.
Note that the container rack 24 may move instead of the sorting head 16 moving.

  The gas supply unit 23 includes a proportional valve 23 </ b> A, a gas cylinder 23 </ b> B, and the like, and sends atomized gas to the outer tube 41 of the sample introduction tube 17 through the flow path 22.

  The control unit 30 including the CPU or the like performs switching operation of the switching valves 4, 7, 15, operation of the liquid feeding pump 6 and the gas supply unit 23 (flow rate or flow velocity), and target temperature of the temperature control unit 28 according to a preset program. And the control of the movement of the preparative head 16 via the XYZ drive mechanism 29, the preparative purification work is automatically performed. The operation unit 31 is used to input and set conditions for the preparative purification work.

Next, the procedure of the gas spraying evaporation / drying process by the preparative purification apparatus of FIG. 1 will be described. First, in order to collect the target component contained in the solution in the solution container 1 in the adsorbent in the trap column 8 and discard the solvent (mobile phase) in the solution, the control unit 30 uses the switching valve 4 to The container 1 (b port) and the flow path 5 (a port) are flown to the flow path 5 (a port) and the flow path 10 (b port) by the switching valve 7, and the flow path 12 (a port) is flowed by the switching valve 15. The passages 13 (c port) are connected to each other, and the liquid feed pump 6 is operated so as to feed liquid at a predetermined constant flow rate. The liquid feed pump 6 sucks the solution in the solution container 1 and introduces it into the trap column 8 through the flow path 5 and the flow path 12. Then, the target component in the solution is collected by the adsorbent in the trap column 8. The mobile phase from which the target component has been removed is discarded through the flow path 12 and the flow path 13 to the waste liquid port.

  When the solution in the solution container 1 is supplied to the trap column 8 for a predetermined time or a predetermined amount, the control unit 30 then switches to connect the pure water container 2 (c port) and the flow path 5 (a port). Switch valve 4. Then, the liquid feed pump 6 sucks the pure water in the pure water container 2 and introduces it into the trap column 8. Thereby, undesired water-soluble substances such as salts adhering to the adsorbent during the collection of the target component are removed from the trap column 8. By supplying pure water, the mobile phase accumulated in the trap column 8 immediately before the start of the supply is replaced with water, and the trap column 8 is filled with water. Since the target component collected in the adsorbent hardly elutes in water due to the strong adsorption action, the state of being collected in the trap column 8 is maintained at this point.

Next, the control unit 30 causes the XYZ drive mechanism 29 to move the sorting head 16 to above the predetermined injection container 21 specified in advance, and lowers the sorting head 16 (FIG. 3B). Thereby, the sample introduction tube 17 is inserted into the injection container main body 19 through the hole provided in the center of the cushion housing recess 42 and the cushion 43. Further, the exhaust seal pipe 18 is also lowered, and the cushion 43 provided on the lid portion 20 is pressed, so that the space between the exhaust seal pipe 18 and the injection container 21 is hermetically sealed.
Then, the control unit 30 instructs the target temperature to the temperature control unit 28, starts heating the temperature control block 27, and starts heating the injection container 21. The target temperature may be about the same as or slightly higher than the boiling point of dichloromethane used as an elution solvent for the target component, and may be about 40 to 45 ° C. Thereafter, the control unit 30 switches the switching valve 4 so as to connect the elution solvent container 3 (d port) and the flow path 5 (a port). As a result, the liquid feed pump 6 sucks the dichloromethane in the elution solvent container 3 and starts to introduce it into the trap column 8.

  When dichloromethane is introduced into the trap column 8, the interface between dichloromethane and water gradually rises with little mixing with the water present in the trap column 8. That is, dichloromethane gradually accumulates from the bottom of the trap column 8 while pushing up water. On the other hand, the pushed-up water overflows from the outlet end at the upper end of the trap column 8, passes through the switching valve 15 and reaches the waste liquid port from the flow path 13. On the other hand, since dichloromethane has a strong dissolution power, the target component collected in the trap column 8 is dissolved in the dichloromethane accumulated in the trap column 8.

When the dichloromethane in the elution solvent container 3 is supplied to the trap column 8 for a predetermined time or in a predetermined amount and water is completely removed from the trap column 8, the switching valve 15 is changed from the flow path 13 ( c port) to the flow path 14 Switch to ( b port) and start sorting the target component. Further, the control unit 30 causes the gas supply unit 23 to start supplying nitrogen gas (or other inert gas). The atomized gas delivered from the gas supply unit 23 is introduced into the outer tube 41 of the sample introduction tube 17 through the flow path 22 and begins to blow out from the tip thereof. The solution sent from the trap column 8, that is, dichloromethane containing the target component, is dropped from the tip of the inner tube 40 of the sample introduction tube 17 through the channel 12 and the channel 14. At the time of this dripping, the solution is sheared by the atomized gas flow blown from the surroundings, and is scattered as fine droplets.

  The injection container 21 is heated to the same temperature as the boiling point of dichloromethane by heat conduction from the temperature control block 27 using the heater 25 as a heat source. Therefore, when a fine droplet of the solution adheres to the inner periphery or inner wall surface of the injection container 21, the solvent (dichloromethane) in the droplet immediately evaporates and the target component remains as a powder. In this way, the powdery target component is deposited on the inner periphery and inner wall surface of the injection container 21. The atomized gas and the evaporated solvent introduced into the injection container 21 are discharged to the outside of the injection container 21 through the exhaust seal pipe 18.

When the above steps are completed, the sorting head 16 is raised. As a result, the sample introduction tube 17 and the exhaust seal tube 18 rise as a unit, while in the injection container 21 used in the present embodiment, the locking portion provided on the inner peripheral side surface of the cushion housing recess 42 of the lid portion 20. 44 Since the cushion 43 is locked by 4 , the cushion 43 does not rise regardless of the rise of the exhaust seal pipe 18. Therefore, even when the sorting head 16 is continuously moved to a position where the next injection container is located and the same process is performed, the process is not hindered by the cushion of the previous injection container.

The above is the procedure of the gas blowing type evaporation / drying process of the present embodiment using the preparative purification apparatus of FIG. Next, modified examples of the injection container and the gas spray type liquid sample injection device of the present embodiment are shown in FIGS.
FIG. 4 is a schematic longitudinal sectional view showing a modification of the exhaust seal pipe 18 of the gas spray type liquid sample injection device. The exhaust seal pipe 18 is provided with a tapered pointed head 45 at the tip thereof. The pointed head 45 is designed such that the outer diameter φ ₂ of the thinnest part is equal to or smaller than the diameter φ _{1 of} the hole provided in the center of the cushion 43 and the outer diameter φ ₃ of the thickest part is larger than φ _1. (FIG. 4 (a)). In the gas spraying evaporation and drying step, the exhaust seal pipe 18 is lowered so that the pointed head 45 having the dimension designed in this way is inserted into the hole in the center of the cushion 43, thereby the pointed tip. According to the inclination of the portion 45, the cushion 43 is pressed from the inside to the outside of the hole (FIG. 4 (b)). Thus, the exhaust seal pipe 18 is hermetically sealed by the cushion 43, the cushion 43 is pressed against the locking portion 4 4, enters the locking portion 4 4 deformed. In this embodiment, a fluorine rubber sponge sheet having closed cells and a hardness of 36 is used as the cushion 43, and the deformed cushion 43 does not immediately return to its original shape when the exhaust seal pipe 18 is lifted up. keep for a while a state that has entered the stop unit 4 4 (a few seconds). Therefore, even if the exhaust seal pipe 18 is raised, the movement of the cushion 43 in the vertical direction is strongly hindered.

FIG. 5 is a schematic longitudinal sectional view showing a modified example of the injection container 21. The injection container 21 is provided with a barb 46 as a locking member on the inner peripheral side surface of the cushion housing recess 42 of the lid 20. When the exhaust seal pipe 18 descends and comes into close contact with the cushion 43 and then rises, the cushion 43 is locked by the return 46, so that the exhaust seal pipe 18 is prevented from rising together with the exhaust seal pipe 18.

  FIG. 6 shows another modification of the injection container 21. The lid portion 20 of the injection container 21 has a protruding portion sleeve tube 47 and a filter 48 in addition to the configuration of FIG. 4 (FIG. 6A). The protruding portion sleeve tube 47 has a joint portion 47A for airtightly connecting the tip of the outer tube 41 of the sample introduction tube 17 on the inlet side, and the protruding portion of the inner tube 40 of the sample introduction tube 17 on the outlet side. The sleeve portion 47B is covered (FIG. 6C).

The outer periphery of the tip of the outer tube 41 and the inner periphery of the joint portion 47B are both inclined so as to become narrower downward. In addition, the inclination angle (the angle formed between the outer tube 41 or the central axis of the joint portion 47B and the inclined surface) is greater in the joint portion 47B than in the outer tube 41 . Thereby, as the sample introduction tube 17 descends, the outer tube 41 (and the inner tube 40) is guided to the center of the joint portion 47B, and the space between the two is hermetically sealed.
The sleeve portion 47B is designed so that the inner diameter of the sleeve portion 47B is narrower at the outlet side tip portion 47C than the inlet side, and when the outer tube 41 is joined to the joint portion 47A, the tip end of the inner tube 40 extends from the tip portion 47C. The length is adjusted so as not to protrude (FIG. 6 (b)). Thereby, it is possible to prevent droplets and powders scattered inside the injection container main body 19 from adhering to the protruding portion of the inner tube 40. Further, since the outer tube 41 is not introduced into the injection container main body 19, no droplets or powder adhere to the outer tube 41. That is, it is possible to prevent contamination from occurring when droplets or powder adhere to the sample introduction tube 17 and a different liquid sample is injected in the next injection container.
It is more preferable that the sleeve portion 47B has such a length that the tip of the inner tube 40 can be accommodated in the tip portion 47C. As a result, the atomized gas that passes through the outer tube 41 and flows through the protruding portion sleeve tube 47 concentrates on the tip of the inner tube 40, so that shearing of the solution dropped from the inner tube 40 is promoted.
The filter 48 prevents the solute powdered inside the injection container body 19 from flowing out to the exhaust seal pipe 18 when the inside of the injection container body 19 is exhausted through the exhaust seal pipe 18. Is.

  As described above, the injection container and the gas spraying type liquid sample injection device according to the present invention have been described using the embodiments. However, it is a matter of course that changes and modifications can be appropriately made within the scope of the present invention.

DESCRIPTION OF SYMBOLS 1 ... Solution container 2 ... Pure water container 3 ... Elution solvent container 4 ... Switching valve 5, 10, 11, 12, 13, 14, 22 ... Flow path 6 ... Liquid feed pump 7 ... Switching valve 8 ... Trap column 9 ... Column rack 15 ... switching valve 16 ... sorting head 17 ... sample introduction pipe 40 ... inner pipe 41 ... outer pipe 18 ... exhaust seal pipe 19 ... injection container body (sample container)
20: Lid (locking member)
DESCRIPTION OF SYMBOLS 21 ... Injection container 23 ... Gas supply part 23A ... Proportional valve 23B ... Gas cylinder 24 ... Container rack 25 ... Heater 26 ... Temperature sensor 27 ... Temperature control block 28 ... Temperature control part 29 ... XYZ drive mechanism 30 ... Control part 31 ... Operation part 42 ... Cushion housing recess 43 ... Cushion (cushion member)
44 ... Locking portion 45 ... Pointed head 46 ... Return 47 ... Protruding portion sleeve tube 47A ... Joint portion 47B ... Sleeve portion 47C ... Tip portion 48 ... Filter

Claims (8)

Gas blowing with a sample inlet tube made of a liquid body sample from a liquid sample tube and atomizing gas outer tube for supplying atomized, and a pre-Symbol exhaust seal pipe provided around the sample introduction tube An injection container used for a liquid sample injection device,
a casting container body having an opening in a) top,
b) a lid portion which is mounted in the opening,
c) a cushion housing recess provided in the lid , having an opening at the top and a hole through which the sample introduction tube passes at the bottom ;
d) an annular cushion member having an abutting surface that is accommodated in the cushion accommodating recess and abutted against a lower end of the exhaust seal pipe;
e) An injecting container for a gas spraying type liquid sample injecting device, comprising: an engaging portion that is provided on an inner peripheral side surface of the cushion housing recess and prevents the cushion member from moving upward. 2. The injection container for a gas spray type liquid sample injection device according to claim 1, wherein the locking portion is a screw-shaped cut provided on the inner peripheral side surface. The injection container for a gas spraying type liquid sample injection device according to claim 2, wherein the locking portion is a barb provided on the inner peripheral side surface. A gas spray type liquid sample injection device for atomizing and supplying a liquid sample into a sample container having an opening at the top,
a) the inner pipe for a liquid sample for feeding the liquid sample, and the sample inlet tube made of atomizing gas outer tube for delivering the gas to atomize the liquid sample,
b) an exhaust seal pipe provided around the sample introduction pipe;
c) a member mounted in the opening, a through hole Ru passed through a sample introduction tube, an annular cushion member the lower end of the exhaust seal pipe having abutting contact surfaces,
d) A member that is attached to the opening , and has a locking member that prevents the cushion member from moving upward when the cushion member is attached to the opening. Liquid sample injection device. The locking member is a lid of the sample container;
The said cover is a recessed part which accommodates the said cushion member, Comprising: The latching | locking part which prevents the upward movement of this cushion member has a cushion accommodation recessed part provided in the inner peripheral surface. Gas spray type liquid sample injection device. The tip of said exhaust seal pipe, the diameter or of a thinnest portion of the outer diameter of the through hole, a large tapered sharp head even outer diameter than the diameter of the through hole of the thickest part is provided The gas spray type liquid sample injection device according to claim 5. The gas spraying liquid sample injection device according to claim 5 or 6, wherein the locking portion is a screw-shaped cut provided on the inner peripheral side surface. The gas spraying liquid sample injection device according to claim 5 or 6, wherein the locking portion is a barb provided on the inner peripheral side surface.

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