JP5860725B2 - Automatic analyzer - Google Patents

Description

  The present invention relates to an automatic analyzer that performs qualitative / quantitative analysis of biological samples such as blood and urine, and more particularly to an automatic analyzer that uses a perforated reagent container that holds a lid for preventing reagent deterioration.

  An automatic analyzer that analyzes a plurality of items of a biological sample (sample) such as blood and urine holds a plurality of reagent containers that contain a first reagent and a third reagent for mixing with the sample and causing a reaction. It is common to have possible reagent container holding means.

  In recent years, the analysis items of biological samples have increased dramatically, and many types of reagents have come to be marketed accordingly. Along with this, various types of reagent containers for storing reagents have been put on the market. One of them is a reagent container in which a reagent container is covered with a lid to prevent concentration of the reagent due to evaporation and the lid is perforated with a nozzle for sucking the reagent in use (hereinafter referred to as this container). This type of reagent container is also called a perforated reagent container.) On the other hand, a reagent container that is opened by removing the lid has also been used conventionally (hereinafter, this type of reagent container is also referred to as an open-type reagent container).

JP 2004-333259 A JP 2008-20361 A JP 2008-20360 A

  When using a perforated reagent container, it is advantageous to prevent concentration and deterioration of the reagent, but it is necessary to open a through-hole for the passage of the reagent dispensing nozzle in the lid and to clean the reagent dispensing nozzle. Since the range is expanded and a longer time is required for cleaning the reagent dispensing nozzle as compared with the open type reagent container, there is a problem in that it is disadvantageous in terms of throughput per unit time.

  Note that Patent Document 1 (Japanese Patent Application Laid-Open No. 2004-333259) describes an automatic analyzer that performs analysis using a perforated reagent cup (container). In this case, as described above, a unit is used. There is a problem in terms of processing capacity per hour.

  Patent Document 2 (Japanese Patent Laid-Open No. 2008-20361) and Patent Document 3 (Japanese Patent Laid-Open No. 2008-20360) describe an automatic analyzer using a perforated reagent container and an open reagent container. However, there is no detailed description on the control of proper use such as the timing of efficiently using the reagent containers of each method.

  An object of the present invention is to maintain an automatic analyzer that can be used in combination with a perforated reagent container and a lid-opened reagent container, while preventing the concentration and deterioration of the reagent without reducing the processing capacity. It is to provide a technology that can.

  The above and other objects and novel features of the present invention will be apparent from the description of this specification and the accompanying drawings.

  Of the inventions disclosed in this application, the outline of typical ones will be briefly described as follows.

  The automatic analyzer according to the present invention is for analyzing a component in the specimen by reacting the specimen with a reagent, containing the reagent and having a pierceable lid attached thereto, A reagent container holding portion that can be mounted by mixing a second reagent container that contains a reagent and has an openable / closable lid, and a reagent that aspirates the reagent contained in the first or second reagent container It has a dispensing nozzle, a washing unit for washing the reagent dispensing nozzle, and a control unit for controlling the operation of an arm that supports the reagent dispensing nozzle. Further, the control unit of the automatic analyzer performs the operations of suctioning and discharging the reagent by the reagent dispensing nozzle and cleaning the reagent dispensing nozzle in the first reagent container and the second reagent container. When controlling the reagent stored in the first reagent container at the same time and in the same operation, after each operation of the suction, discharge, and washing, This cycle is maintained, and control is performed so that the entire reagent dispensing nozzle related to the first reagent container is cleaned.

  Of the inventions disclosed in the present application, effects obtained by typical ones will be briefly described as follows.

  In an automatic analyzer that can be used with both a perforated reagent container and an open reagent container, it can be maintained without reducing the processing capacity of the automatic analyzer while preventing reagent concentration and deterioration. .

It is a schematic plan view which shows an example of a structure of the automatic analyzer of Embodiment 1 of this invention. It is a block diagram which shows an example of the reagent sampling mechanism in the automatic analyzer of FIG. It is a nozzle operation | movement figure which shows an example of the movable area | region of the reagent dispensing nozzle in the automatic analyzer of FIG. FIG. 2 is a nozzle operation diagram illustrating an example of a positional relationship of operation control of a reagent dispensing nozzle in the automatic analyzer of FIG. 1. It is a time chart which shows an example of the control method of the reagent sampling mechanism in the automatic analyzer of FIG. It is a time chart which shows an example of the control method in case the reagent sampling mechanism of the automatic analyzer of FIG. It is a conceptual diagram which shows an example of the cleaning method (tip cleaning and whole cleaning) of the reagent dispensing nozzle in the automatic analyzer of FIG.

  In the following embodiments, the description of the same or similar parts will not be repeated in principle unless particularly necessary.

  Further, in the following embodiment, when it is necessary for the sake of convenience, the description will be divided into a plurality of sections or embodiments, but they are not irrelevant to each other unless otherwise specified. The other part or all of the modifications, details, supplementary explanations, and the like are related.

  Also, in the following embodiments, when referring to the number of elements (including the number, numerical value, quantity, range, etc.), particularly when clearly indicated and when clearly limited to a specific number in principle, etc. Except, it is not limited to the specific number, and it may be more or less than the specific number.

  Further, in the following embodiments, the constituent elements (including element steps) are not necessarily indispensable unless otherwise specified and clearly considered essential in principle. Needless to say.

  Further, in the following embodiments, regarding constituent elements and the like, when “consisting of A”, “consisting of A”, “having A”, and “including A” are specifically indicated that only those elements are included. It goes without saying that other elements are not excluded except in the case of such cases. Similarly, in the following embodiments, when referring to the shapes, positional relationships, etc. of the components, etc., the shapes are substantially the same unless otherwise specified, or otherwise apparent in principle. And the like are included. The same applies to the above numerical values and ranges.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. Note that components having the same function are denoted by the same reference symbols throughout the drawings for describing the embodiments, and the repetitive description thereof will be omitted. Further, even a plan view may be hatched for easy understanding of the drawing.

(Embodiment)
1 is a schematic plan view showing an example of the configuration of an automatic analyzer according to Embodiment 1 of the present invention, FIG. 2 is a block diagram showing an example of a reagent sampling mechanism in the automatic analyzer of FIG. 1, and FIG. 3 is a diagram of FIG. FIG. 4 is a nozzle operation diagram illustrating an example of a positional relationship of operation control of the reagent dispensing nozzle in the automatic analyzer of FIG. 1. FIG. 4 is a nozzle operation diagram illustrating an example of a movable region of the reagent dispensing nozzle in the automatic analyzer.

  The automatic analyzer 13 according to the present embodiment shown in FIG. 1 analyzes a component in a specimen by reacting a specimen (hereinafter also referred to as a sample) with a reagent. A sample disk 2 capable of setting a plurality of sample containers 1 containing samples, a reaction disk 4 holding a plurality of reaction cells 3 for performing reaction and photometry, a sample being sucked from the sample disk 2 and reacting A specimen sampling mechanism 5 for dispensing the sample to the disk 4 is provided. The automatic analyzer 13 can store a plurality of reagent containers 6 filled with first, second, and third reagents that react by mixing with a sample, and a reagent disk (reagent container holding unit) that performs cold storage. 7, R (Reagent) 1 reagent sampling mechanism 8 for dispensing the reagent from the reagent container 6 to the reaction disk 4, R2 / 3 reagent sampling mechanism 9 for the third reagent, and the reaction disk 4 And a photometric unit 10 for photometric measurement of the mixture of the sample and the reagent reacting above. Furthermore, the automatic analyzer 13 cleans the code reading mechanism (code reading unit) 11 that reads the identification code provided in the reagent container 6 and the reagent dispensing nozzle 31 (see FIG. 2) of the reagent sampling mechanisms 8 and 9. A cleaning mechanism (cleaning unit) 12 is provided.

  The automatic analyzer 13 according to the present embodiment includes a control unit 14 that controls the operation of each table (each disk) and each mechanism, but the operation control of each disk and each mechanism is not illustrated. You may carry out by the control apparatus which consists of a computer etc.

  The automatic analyzer 13 according to the present embodiment includes both a perforated reagent container (first reagent container) 6a and an open reagent container (second reagent container) 6b as shown in FIG. Is enabled. In the perforation method, a lid 34 is provided on the reagent container 6, and the lid 34 is perforated using a nozzle or the like (a member other than the nozzle may be used) in use, and the reagent 15 is sucked through the nozzle into the hole formed by the perforation. It is a method to do. On the other hand, the opening method is a method in which the lid 34 arranged in the opening 6c of the reagent container 6 is removed before the reagent is sucked, and the reagent 15 is sucked through the nozzle into the opening 6c.

  Therefore, the reagent disk 7 which is the reagent container holding part of the automatic analyzer 13 according to the present embodiment has a structure in which a perforated reagent container 6a and an open reagent container 6b can be mixedly mounted.

  As described above, the perforated reagent container 6a is the reagent container 6 that is filled (contained) with the reagent 15 and has a perforated lid 34 attached thereto, while the open reagent container 6b contains the reagent 15. When the reagent 15 is filled (accommodated) and can be opened and closed, and the reagent dispensing nozzle 31 sucks the reagent 15, the reagent container 6 can be opened to form an open state.

  Therefore, the reagent dispensing nozzle 31 can suck the reagent 15 filled (contained) in the reagent container 6a and the reagent container 6b, and when sucking the reagent 15 filled in the perforated reagent container 6a, As shown in FIG. 4, the reagent 15 is sucked through a through hole 34 a formed in the lid 34.

  Next, the reagent sampling mechanism shown in FIG. 2 will be described. The reagent sampling mechanism in FIG. 2 corresponds to the R1 reagent sampling mechanism 8 or the R2 / 3 reagent sampling mechanism 9 in FIG. 1. Here, the R1 reagent sampling mechanism 8 will be described as a representative, but R2 / 3 will be described. The reagent sampling mechanism 9 has the same configuration and operation.

  The reagent dispensing nozzle 31 provided in the R1 reagent sampling mechanism 8 operates in a combination of operations in the horizontal direction (surface direction parallel to the rotation directions P and Q in FIG. 2) and the vertical direction R.

  The horizontal operation is performed by a combination of the rotation P of the first arm 29 and the rotation Q of the second arm 30. The first arm 29 is rotated by transmitting the rotational driving force of the first arm drive motor 20 to the first arm shaft 32 and the first arm 29 by the first arm belt 21.

  On the other hand, the second arm 30 has the rotational driving force of the second arm drive motor 22 transmitted to the second arm shaft 33 and is further in the first arm 29 via the second arm belt 26 and the second arm 30. This is performed by being transmitted to the shaft 27 which is the rotation center of 30.

  Therefore, as shown in FIG. 3, the dispensing nozzle access area 36 is a wide area combining the first arm movable area 37 and the second arm movable area 38.

  2 is transmitted to the first arm shaft 32 through the vertical movement belt 24 and the slider 25, so that the first arm 29 and the second arm are operated in the vertical direction R shown in FIG. 30 moves up and down simultaneously. In the present embodiment, the R1 reagent sampling mechanism 8 is configured to operate by rotating the arm, but may be configured to operate in the horizontal direction.

  When the reagent container 6 is installed on the reagent disk 7 shown in FIG. 1, first, a perforation method and an opening method are set for each reagent item from the input unit 16 such as a computer, a screen, or a remote. That is, the automatic analyzer 13 of the present embodiment can set the switching between the reagent container 6a and the reagent container 6b used for each item to be measured for the reagent 15 accommodated in the reagent container 6.

  Thereafter, in accordance with the above setting, when the setting is a perforation method, as shown in FIG. 2, the reagent dispensing nozzle 31 can pass through the lid 34 of the reagent container 6a by the perforating part hole opening mechanism (hole forming part) 28. A through hole 34a (see FIG. 4) is formed.

  On the other hand, when the setting is the opening method, the lid 34 is removed by the lid opening mechanism (opening portion) 35 before the reagent is sucked to form the opening 6c in the reagent container 6b. The reagent 15 is sucked through the reagent dispensing nozzle 31 into the opening 6c.

  In the present embodiment, as shown in FIG. 2, the perforation part hole opening mechanism 28 and the lid opening mechanism 35 are attached to the second arm 30 provided with the reagent dispensing nozzle 31. The part hole opening mechanism 28 and the lid opening mechanism 35 may be provided at a location (member) different from the second arm 30 provided with the reagent dispensing nozzle 31.

  The automatic analyzer 13 can also fetch setting information for switching between the reagent container 6a and the reagent container 6b from an external interface. That is, using a storage medium (for example, a readable / writable disk or memory) that stores the setting information, an extraction unit (for example, a computer) that can extract the setting information for switching between the reagent container 6a and the reagent container 6b. May be provided. The extraction means in this case may be different from the input unit 16 or may be incorporated in the input unit 16.

  In addition to the setting method described above, the identification code provided (attached) to the reagent container 6 may be read and identified by the code reading mechanism (code reading unit) 11 shown in FIG. By providing the function of judging the perforation method and the opening method, the through hole 34a shown in FIG. 4 is formed in the lid 34 with respect to the reagent container 6a as shown in FIG. The lid 34 of the container 6b can be removed.

  That is, the automatic analyzer 13 can read a code reading mechanism (code reading unit) 11 that can read an identification code holding an identifier in the reagent container 6, and the reagent container 6a from the identification code read by the code reading mechanism 11. A container discriminating means 17 for discriminating the reagent container 6b; and by adding the identification code to the reagent container 6, the reagent container 6a and the reagent container 6b are read from the identification code read by the code reading mechanism 11; Can be determined.

  Thus, when it is determined from the identification code that the reagent container 6 is the reagent container 6a, as shown in FIG. A through hole 34a shown in FIG. 4 through which the reagent dispensing nozzle 31 can pass is formed, and the reagent 15 is sucked through the through hole 34a.

  On the other hand, when it is determined from the identification code that the reagent container 6 is the reagent container 6b, the lid 34 is removed by the lid opening mechanism (opening portion) 35 before the reagent suction, and the opening 6c is opened in the reagent container 6b. Is formed, and the reagent 15 is aspirated through the opening 6c.

  In addition, the code reading mechanism 11 and the container determination means 17 may be integrally formed. That is, the container determination unit 17 may be incorporated in the code reading mechanism 11.

  Next, the R1 reagent sampling mechanism 8 shown in FIG. 2 (the same applies to the R2 / 3 reagent sampling mechanism 9) operates in the vertical direction from the reference position, and the reagent dispensing nozzle 31 provided in the second arm 30 is After being inserted into the reagent container 6a or the reagent container 6b and performing a lowering operation, the reagent 15 is aspirated.

  In addition, the R1 reagent sampling mechanism 8 includes an abnormal lowering detection unit that detects when the reagent dispensing nozzle 31 collides with a foreign object during the lowering operation. Abnormal descent detection is to detect, using a photocoupler (photo interrupter), that the reagent dispensing nozzle 31 has moved upward (stopped upward) from its original position when the tip of the reagent dispensing nozzle 31 collides with a foreign substance. is there. As the abnormal lowering detection is activated, the reagent dispensing nozzle 31 is stopped from being lowered, thereby preventing the reagent dispensing nozzle 31 from being damaged and the operator being injured.

  The nozzle height at the time when the abnormal lowering detection is detected can be calculated from the number of pulses of the pulse motor of the nozzle vertical movement mechanism.

  In addition, the automatic analyzer 13 may include a liquid level sensor that detects that the reagent dispensing nozzle 31 is in contact with the reagent liquid level in the reagent container 6 based on a change in electric conductivity, capacitance, or the like. .

  Therefore, in the perforated reagent container 6a, when the R1 reagent sampling mechanism 8 performs the reagent dispensing operation as shown in FIG. 4, the reagent dispensing nozzle 31 is lowered (S) before and after passing through the lid 34. In a specific area (A: first low speed area 41, B: second low speed area 42), it is necessary to control the lowering speed of the reagent dispensing nozzle 31 to a low speed. Here, the first low speed region 41 and the second low speed region 42 are controlled by the control unit 14 and pass through the region immediately before the lid 34 passes at the first low speed, and the lid 34 and the region immediately after the lid passes through the region. By passing at a second low speed that is slower than the first low speed, the reagent dispensing nozzle 31 can be smoothly passed through the through hole 34a of the lid 34, and the reagent dispensing nozzle 31 can be prevented from being damaged. Can do.

  At this time, since the reagent dispensing nozzle 31 and the lid 34 are in contact with each other, the range of contamination of the reagent dispensing nozzle 31 is larger than that in the case of the reagent container 6b of the opening method. Therefore, in the perforation method, the cleaning time of the reagent dispensing nozzle 31 after the reagent 15 is aspirated needs to be longer than that in the opening method. Furthermore, it is necessary to prevent (reduce) variations in measurement results due to the difference between the opening method and the drilling method.

  In order to cope with these problems, in the automatic analyzer 13 of the present embodiment, each operation of the reagent dispensing nozzle 31 for aspirating and discharging the reagent 15 and cleaning the reagent dispensing nozzle 31 is performed in a perforated reagent container. In the case of 6a and in the case of the open-type reagent container 6b, the control unit 14 controls the same time and the same operation, and also measures the perforation-type reagent items (the perforation-type reagent container 6a). In the case of analyzing the reagent 15 contained in the container, the control unit 14 controls the suction, discharge, and cleaning operations, and then the perforation type reagent container is maintained in a state where the cycles of the operations are maintained. Control is performed so that the entire reagent dispensing nozzle 31 associated with 6a is cleaned.

  That is, when measuring a reagent item using the perforated reagent container 6a, additional operations are performed after performing the operations of suctioning and discharging the reagent 15 by the reagent dispensing nozzle 31 and washing the reagent dispensing nozzle 31. One cycle is ensured, and in this additional one cycle, the control unit 14 can control to interrupt the cleaning operation of the entire nozzle specialized for the perforation type reagent 15.

  Here, FIG. 5 is a time chart showing an example of a control method of the reagent sampling mechanism in the automatic analyzer of FIG. 1, and FIG. 6 is an example of a control method when the reagent sampling mechanism of the automatic analyzer of FIG. It is a time chart which shows. FIG. 5 shows a control cycle of each operation when the R1 reagent sampling mechanism 8 and the R2 / 3 reagent sampling mechanism 9 operate in the opening method and the punching method, respectively. In the case of the method, for example, after one cycle of each of the above operations, an additional cycle for the entire cleaning (entire cleaning of the reagent dispensing nozzle 31) operation is interrupted independently, and the R2 / 3 reagent sampling mechanism 9 Similarly, in the case of the perforation method, for example, after two cycles of each of the above operations, an additional cycle for the entire cleaning (the entire cleaning of the reagent dispensing nozzle 31) is interrupted independently. 14 is done.

  FIG. 6 shows an example of the control cycle of the reagent sampling mechanism when the reagent sampling mechanism has only one arm system and has the functions of R1 and R2 / 3. In other words, even in the case of the reagent sampling mechanism having only one arm system, in the case of the perforation method, for example, after one cycle of each operation, an additional operation for the entire cleaning (the entire cleaning of the reagent dispensing nozzle 31) is performed. It goes without saying that control is possible even if the cycle is interrupted independently.

  Here, with reference to FIG. 7, the cleaning of the reagent dispensing nozzle 31 (normal cleaning, tip cleaning) and the total cleaning (whole cleaning) will be described. FIG. 7 is a conceptual diagram showing an example of the reagent dispensing nozzle cleaning method (tip cleaning and overall cleaning) in the automatic analyzer of FIG. 1, and shows the difference in cleaning position of each cleaning method.

  As shown in FIG. 7, the reagent dispensing nozzle 31 is cleaned (tip cleaning) by cleaning the tip 31a of the reagent dispensing nozzle 31. This tip cleaning is nozzle cleaning in the case of using the open-type reagent container 6b, and the tip vicinity including the tip 31a of the reagent dispensing nozzle 31 is cleaned.

  On the other hand, the entire cleaning of the reagent dispensing nozzle 31 is to clean the tip 31a of the reagent dispensing nozzle 31 and the main body 31b that supports the tip 31a. This total cleaning (total cleaning) is nozzle cleaning in the case of using a perforated reagent container 6a, and the vicinity of the tip including the tip 31a of the reagent dispensing nozzle 31 and the main body portion supporting the vicinity of the tip in addition to this. 31b is washed. In the perforation method, since more dirt adheres to the reagent dispensing nozzle 31 than in the opening method, the cleaning time takes longer than that in the opening method.

  Further, at the time of cleaning, the reagent dispensing nozzle 31 is inserted into the cylindrical cleaning tank 12a of the cleaning mechanism (cleaning unit) 12 from the tip 31a, and with respect to the reagent dispensing nozzle 31 near the opening of the cleaning tank 12a. Cleaning is performed by spraying the cleaning water 39.

  Accordingly, in the tip cleaning, the vicinity of the tip of the reagent dispensing nozzle 31 is allowed to enter the cleaning tank 12a. That is, in the front end cleaning (opening method), the front end 31a is lowered from the home position C to the lowering range D in the cleaning tank 12a, thereby cleaning to the cleaning range E.

  On the other hand, in the entire cleaning (total cleaning, perforation method), the cleaning to the cleaning range G is performed by lowering the tip 31a from the home position C to the lowering range F in the cleaning tank 12a. Therefore, the tip cleaning in the cleaning mechanism 12 of the reagent dispensing nozzle 31 of the automatic analyzer 13 cleans the vicinity of the tip including the tip 31a of the reagent dispensing nozzle 31, whereas the tip cleaning is performed in the entire cleaning (total cleaning). The cleaning range is wider, and the operation time is longer than the cleaning of the tip 31a of the reagent dispensing nozzle 31 (tip cleaning). That is, the size relationship between the cleaning range and the operation time is such that the cleaning range E of the front end cleaning <the cleaning range G of the total cleaning and the operating time of the front end cleaning <the operating time of the total cleaning.

  Further, in the automatic analyzer 13 of the present embodiment, when the perforation method and the opening method are identified, the stability period of the reagent 15 shown in FIG. 2 after the reagent container 6 is mounted on the reagent disk 7 is individually determined for each method. And the elapsed time (period) is monitored according to the stable period, and if the mounted specific reagent 15 exceeds the stable period, the operator is informed that “the reagent has exceeded the stable period”. Making it possible.

  That is, the automatic analyzer 13 of the present embodiment shown in FIG. 1 determines whether the reagent container 6a and the reagent container 6b are the reagent container 6a or the reagent container 6b from the identification code attached to each reagent container 6. 2), and the stability period of the reagent 15 shown in FIG. 2 after the reagent container 6a or the reagent container 6b is mounted on the reagent disk 7 can be set and stored individually for each reagent container 6a and reagent container 6b. The storage unit 18 may be provided.

  Furthermore, the automatic analyzer 13 monitors the elapsed time (period) according to the stability period of the reagent 15 after being mounted on the reagent disk 7, and when the specific reagent 15 mounted exceeds the stable period. May include a monitoring unit 19 for informing the operator.

  As a result, as described above, when the reagent 15 mounted on the reagent disk 7 exceeds the stable period, the operator can be informed that “the reagent has exceeded the stable period”.

  Furthermore, in the automatic analyzer 13 according to the present embodiment, the stabilization period is set longer in the case of the perforation method with the lid 34 according to the deterioration degree of the reagent 15 due to the difference between the perforation method and the opening method. On the other hand, in the case of the opening method without the lid 34, the stable period can be set short. Thus, by monitoring the reagent 15 by the monitoring unit 19 using the set stable period of the reagent 15, measurement (analysis) in a stable state of the reagent 15 can be ensured according to the method.

  According to the automatic analyzer 13 of the present embodiment, the perforation type reagent container 6a and the open type reagent container 6b can be used together, and the perforation type reagent container 6a and the open type reagent container 6b can be used. By making it possible to set for each measurement (analysis) item separately, it is possible to prevent the concentration and deterioration of the reagent 15 and to maintain the processing capacity of the automatic analyzer 13 without reducing it.

  In other words, the concentration and deterioration of the reagent 15 can be prevented by switching the operation time of the reagent dispensing operation (rotation / aspiration / discharge) and the cleaning operation according to the setting of the perforation method and the opening method for each reagent item. In addition, it is possible to realize the automatic analyzer 13 capable of both maintaining the processing capability and maintaining the stability of the measurement result.

  Specifically, in the automatic analyzer 13 of the present embodiment, as shown in FIGS. 5 and 6, the operation cycle of each operation of the reagent dispensing operation and the cleaning operation is set to the operation cycle set before the operation starts. Without changing, the cleaning of the reagent dispensing nozzle 31 (perforation method) can be interrupted in a part of the operation cycle while maintaining the operation cycle. Thus, in the automatic analyzer 13, each operation is performed while maintaining the same operation cycle in the drilling method and the opening method without spending time by stopping the apparatus for changing the method between the drilling method and the opening method. (Processing) can be performed efficiently.

  Therefore, since the perforation method can be used, the opening method can be used in the same cycle as the perforation method while preventing the concentration and deterioration of the reagent 15, so that each operation (without reducing the throughput of the automatic analyzer 13) Processing).

  Here, in the present embodiment, the case where both the reagent dispensing operation and the cleaning operation of the reagent dispensing nozzle 31 are switched has been described, but it is easily assumed that only one of them is switched. Furthermore, in the present embodiment, the switching of the difference with respect to the operation time is shown, but the control that requires switching due to the difference between the punching method and the opening method can be controlled according to the switching setting information described above. Needless to say.

  As mentioned above, the invention made by the present inventor has been specifically described based on the embodiments of the invention. However, the present invention is not limited to the embodiments of the invention, and various modifications can be made without departing from the scope of the invention. It goes without saying that it is possible.

  For example, in the embodiment, the case where the control unit 14, the input unit 16, the container determination unit 17, the storage unit 18, and the monitoring unit 19 are individually provided in the automatic analyzer 13 has been described as an example. However, for example, one or more of the input unit 16, the container determination unit 17, the storage unit 18, and the monitoring unit 19 may be provided integrally with the control unit 14.

  INDUSTRIAL APPLICABILITY The present invention can be widely used in analyzers that perform analysis by reacting a specimen and a reagent.

DESCRIPTION OF SYMBOLS 1 Sample container 2 Sample disk 3 Reaction cell 4 Reaction disk 5 Sample sampling mechanism 6 Reagent container 6a Reagent container (1st reagent container)
6b Reagent container (second reagent container)
6c Opening 7 Reagent disc (reagent container holder)
8 R1 reagent sampling mechanism 9 R2 / 3 reagent sampling mechanism 10 Photometry unit 11 Code reading mechanism (code reading unit)
12 Cleaning mechanism (cleaning part)
12a Washing tank 13 Automatic analyzer 14 Control unit 15 Reagent 16 Input unit 17 Container discriminating means 18 Storage unit 19 Monitoring unit 20 First arm drive motor 21 First arm belt 22 Second arm drive motor 23 Vertical motion drive motor 24 Vertical motion Belt for operation 25 Slider 26 Belt for second arm 27 Shaft 28 Drilling part hole opening mechanism (hole forming part)
29 First Arm 30 Second Arm 31 Reagent Dispensing Nozzle 31a Tip 31b Main Body 32 First Arm Shaft 33 Second Arm Shaft 34 Lid 34a Through Hole 35 Lid Opening Mechanism (Lid Opening)
36 Dispensing nozzle access area 37 First arm movable area 38 Second arm movable area 39 Washing water 41 First low speed area 42 Second low speed area

Claims (12)

An automatic analyzer that analyzes a component in the sample by reacting the sample with a reagent,
Board that accommodates the reagent, and a first reagent container perforations closable lid is attached, housing the reagent, and mounting a reagent container containing a second reagent container openable lid is attached, the A reagent container holding portion which is a member ,
A hole forming part for punching the lid of the first reagent container mounted on the reagent container holding part;
An opening part for opening the lid of the second reagent container mounted on the reagent container holding part;
An identification unit for identifying whether the reagent container is the first reagent container or the second reagent container;
A reagent dispensing nozzle for aspirating the reagent contained in the first or second reagent container;
A cleaning section for cleaning the reagent dispensing nozzle;
A controller that controls the operation of the arm that supports the reagent dispensing nozzle;
Have
The control unit is configured to suck and discharge the reagent by the reagent dispensing nozzle and wash the reagent dispensing nozzle between the first reagent container and the second reagent container based on the identification result by the identifying unit. When the analysis is performed by reacting the reagent contained in the first reagent container with the sample , the aspiration, discharge, and washing are controlled. The automatic analyzer is controlled to perform the entire cleaning of the reagent dispensing nozzle related to the first reagent container while maintaining the cycle of each operation after each of the operations. The automatic analyzer according to claim 1, wherein
An automatic analyzer, wherein the switching between the first reagent container and the second reagent container can be set for each item to be measured for the reagent contained in the reagent container. The automatic analyzer according to claim 2,
The setting information for switching can be taken from an external interface, and the setting information for switching the first reagent container and the second reagent container is extracted from the storage medium using a storage medium that stores the setting information. A take-out means capable of
Automatic analyzer characterized that you have provided the retrieval means as the identification unit. The automatic analyzer according to claim 1, wherein
An identification code holding an identifier is added to the reagent container, and a code reading unit capable of reading the identification code is provided, and the first reagent container and the second reagent are read from the identification code read by the code reading unit. A container discriminating means for discriminating the container ;
Automatic analyzer characterized that you have provided the container discrimination means as the identification unit. The automatic analyzer according to claim 4,
When the reagent containers from the identification code is determined to be the first reagent container, characterized in that it comprises the said hole forming portion capable of forming a through hole in the lid of the first reagent container Automatic analyzer. The automatic analyzer according to claim 4,
An automatic analyzer comprising: the opening portion capable of removing the lid of the second reagent container when it is determined from the identification code that the reagent container is the second reagent container . The automatic analyzer according to claim 4,
The first reagent container and the second reagent container are discriminated from the identification code, and the stability period of the reagent after the first or second reagent container is mounted on the reagent container holding part is defined as the first and second reagent containers. An automatic analyzer comprising a storage unit that can be individually set and stored for each second reagent container. The automatic analyzer according to claim 7,
A monitoring unit is provided that monitors the time according to the stability period of the reagent after being mounted on the reagent container holding unit, and notifies an operator when the specific reagent loaded exceeds the stability period. An automatic analyzer. The automatic analyzer according to claim 1, wherein
The cleaning of the reagent dispensing nozzle is to clean the tip of the reagent dispensing nozzle, and the overall cleaning of the reagent dispensing nozzle is to clean the tip of the reagent dispensing nozzle and the main body that supports the tip. A featured automatic analyzer. The automatic analyzer according to claim 9, wherein
2. The automatic analyzer according to claim 1, wherein the entire cleaning of the reagent dispensing nozzle takes longer than the cleaning of the tip of the reagent dispensing nozzle. An automatic analyzer that analyzes a component in the sample by reacting the sample with a reagent,
A board carrying a reagent container containing the reagent and having a first reagent container with a pierceable lid attached and a second reagent container containing the reagent and having a lid that can be opened and closed A reagent container holding portion which is a member,
A hole forming part for punching the lid of the first reagent container mounted on the reagent container holding part;
An opening part for opening the lid of the second reagent container mounted on the reagent container holding part;
A reagent dispensing nozzle for aspirating the reagent contained in the first or second reagent container;
A cleaning section for cleaning the reagent dispensing nozzle;
A controller that controls the operation of the arm that supports the reagent dispensing nozzle;
Have
The control unit identifies whether the reagent container is the first reagent container or the second reagent container, and based on the identification result, the first reagent container and the second reagent container, The reagent suction and discharge by the reagent dispensing nozzle and the operations of cleaning the reagent dispensing nozzle are controlled in the same time and the same operation, and the reagent contained in the first reagent container When the sample is reacted and analyzed, the entire reagent dispensing nozzle related to the first reagent container is maintained by maintaining the cycle of the operations after the operations of the suction, discharge, and washing. An automatic analyzer characterized by controlling to perform washing. In the automatic analyzer according to any one of claims 1 to 11,
The hole forming portion and the lid opening portion are included in a sampling mechanism including a mechanism for perforating the lid of the first reagent container and removing the lid of the second reagent container. Automatic analyzer to do.

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