JP5856982B2 - 二官能性キレート化剤 - Google Patents
二官能性キレート化剤 Download PDFInfo
- Publication number
- JP5856982B2 JP5856982B2 JP2012553161A JP2012553161A JP5856982B2 JP 5856982 B2 JP5856982 B2 JP 5856982B2 JP 2012553161 A JP2012553161 A JP 2012553161A JP 2012553161 A JP2012553161 A JP 2012553161A JP 5856982 B2 JP5856982 B2 JP 5856982B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- nmr
- mhz
- dedpa
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30625610P | 2010-02-19 | 2010-02-19 | |
| US61/306,256 | 2010-02-19 | ||
| US39473910P | 2010-10-19 | 2010-10-19 | |
| US61/394,739 | 2010-10-19 | ||
| PCT/CA2011/000187 WO2011100829A1 (en) | 2010-02-19 | 2011-02-18 | Bifunctional chelating agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013519692A JP2013519692A (ja) | 2013-05-30 |
| JP5856982B2 true JP5856982B2 (ja) | 2016-02-10 |
Family
ID=44482427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012553161A Active JP5856982B2 (ja) | 2010-02-19 | 2011-02-18 | 二官能性キレート化剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8772446B2 (OSRAM) |
| EP (2) | EP3318555B1 (OSRAM) |
| JP (1) | JP5856982B2 (OSRAM) |
| DK (1) | DK2536691T3 (OSRAM) |
| ES (1) | ES2962520T3 (OSRAM) |
| NO (1) | NO2536691T3 (OSRAM) |
| WO (1) | WO2011100829A1 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11274268B2 (en) | 2017-03-23 | 2022-03-15 | Fng Research Co., Ltd. | Detergent compositions for removing heavy metals and formaldehyde |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014075079A1 (en) * | 2012-11-12 | 2014-05-15 | The General Hospital Corporation | Peptidic structures incorporating an amino acid metal complex and applications in magnetic resonance imaging |
| DE102013113156A1 (de) | 2013-11-28 | 2015-05-28 | Freie Universität Berlin | Verbindung und Verfahren zur selektiven Radiomarkierung von Polypeptiden mittels Festphasensynthese |
| CN104152520B (zh) * | 2014-07-30 | 2017-01-18 | 华南理工大学 | 一种具有抗肿瘤活性的核桃多肽‑锌螯合物的制备方法 |
| ES2987778T3 (es) | 2015-08-13 | 2024-11-18 | Massachusetts Gen Hospital | Conjugados de quelatos a base de manganeso para la imagenología por resonancia magnética molecular |
| CN106496110B (zh) * | 2016-09-05 | 2019-04-23 | 郑州大学 | 金属β-内酰胺酶抑制剂开链吡啶羧酸衍生物及其制备方法 |
| JP2024125438A (ja) * | 2021-08-03 | 2024-09-19 | 住友化学株式会社 | 放射性金属錯体及びその製造方法、並びに放射性金属捕捉剤 |
| CN116041257B (zh) * | 2023-02-02 | 2024-10-15 | 杭州谱康医学科技有限公司 | 金属螯合配体及其制备方法、应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5021567A (en) | 1987-09-24 | 1991-06-04 | Abbott Laboratories | 8-hydroxyquinoline chelating agents |
| US5220000A (en) * | 1992-01-23 | 1993-06-15 | Spyros Theodoropulos | Bifunctional-bis-quinolinols, and their metal chelates |
| FR2890657B1 (fr) * | 2005-09-15 | 2007-11-09 | Commissariat Energie Atomique | Procede d'obtention de complexes de lanthanides hautement luminescents. |
| FR2896501B1 (fr) | 2006-01-20 | 2008-04-25 | Commissariat Energie Atomique | Nouveaux ligands et complexes de lanthanides, et leur utilisation en tant qu'agents de contraste |
-
2011
- 2011-02-18 NO NO11744221A patent/NO2536691T3/no unknown
- 2011-02-18 EP EP17200176.0A patent/EP3318555B1/en active Active
- 2011-02-18 JP JP2012553161A patent/JP5856982B2/ja active Active
- 2011-02-18 DK DK11744221.0T patent/DK2536691T3/en active
- 2011-02-18 ES ES17200176T patent/ES2962520T3/es active Active
- 2011-02-18 US US13/030,766 patent/US8772446B2/en active Active
- 2011-02-18 EP EP11744221.0A patent/EP2536691B1/en active Active
- 2011-02-18 WO PCT/CA2011/000187 patent/WO2011100829A1/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11274268B2 (en) | 2017-03-23 | 2022-03-15 | Fng Research Co., Ltd. | Detergent compositions for removing heavy metals and formaldehyde |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3318555B1 (en) | 2023-08-16 |
| NO2536691T3 (OSRAM) | 2018-04-21 |
| WO2011100829A8 (en) | 2011-10-27 |
| DK2536691T3 (en) | 2018-02-19 |
| JP2013519692A (ja) | 2013-05-30 |
| EP3318555C0 (en) | 2023-08-16 |
| US20110313130A1 (en) | 2011-12-22 |
| EP3318555A1 (en) | 2018-05-09 |
| US8772446B2 (en) | 2014-07-08 |
| EP2536691A1 (en) | 2012-12-26 |
| EP2536691B1 (en) | 2017-11-22 |
| ES2962520T3 (es) | 2024-03-19 |
| EP2536691A4 (en) | 2013-08-14 |
| WO2011100829A1 (en) | 2011-08-25 |
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