JP5856955B2 - Emulsified cosmetics using fish-derived cholesterol - Google Patents
Emulsified cosmetics using fish-derived cholesterol Download PDFInfo
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- JP5856955B2 JP5856955B2 JP2012522571A JP2012522571A JP5856955B2 JP 5856955 B2 JP5856955 B2 JP 5856955B2 JP 2012522571 A JP2012522571 A JP 2012522571A JP 2012522571 A JP2012522571 A JP 2012522571A JP 5856955 B2 JP5856955 B2 JP 5856955B2
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title claims description 194
- 235000012000 cholesterol Nutrition 0.000 title claims description 98
- 239000002537 cosmetic Substances 0.000 title claims description 33
- 241000251468 Actinopterygii Species 0.000 title claims description 29
- 235000019688 fish Nutrition 0.000 claims description 28
- 239000004166 Lanolin Substances 0.000 claims description 18
- 235000019388 lanolin Nutrition 0.000 claims description 18
- 229940039717 lanolin Drugs 0.000 claims description 18
- 235000019512 sardine Nutrition 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 9
- 229930182558 Sterol Natural products 0.000 claims description 8
- 150000003432 sterols Chemical class 0.000 claims description 8
- 235000003702 sterols Nutrition 0.000 claims description 8
- INDVLXYUCBVVKW-RNWIMVDMSA-N 24-Methylene cholesterol Natural products O[C@@H]1CC=2[C@@](C)([C@H]3[C@H]([C@H]4[C@@](C)([C@@H]([C@@H](CCC(C(C)C)=C)C)CC4)CC3)CC=2)CC1 INDVLXYUCBVVKW-RNWIMVDMSA-N 0.000 claims description 6
- INDVLXYUCBVVKW-PXBBAZSNSA-N 24-methylenecholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCC(=C)C(C)C)[C@@]1(C)CC2 INDVLXYUCBVVKW-PXBBAZSNSA-N 0.000 claims description 6
- INDVLXYUCBVVKW-UHFFFAOYSA-N Methylencholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(=C)C(C)C)C1(C)CC2 INDVLXYUCBVVKW-UHFFFAOYSA-N 0.000 claims description 6
- 238000004817 gas chromatography Methods 0.000 claims description 3
- 241001125046 Sardina pilchardus Species 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 30
- 239000006071 cream Substances 0.000 description 20
- 210000004209 hair Anatomy 0.000 description 19
- 238000011282 treatment Methods 0.000 description 15
- 238000000034 method Methods 0.000 description 14
- 235000021323 fish oil Nutrition 0.000 description 13
- 210000003491 skin Anatomy 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 241001125048 Sardina Species 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- 238000004821 distillation Methods 0.000 description 8
- 239000002994 raw material Substances 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 235000019198 oils Nutrition 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 238000000199 molecular distillation Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 238000001035 drying Methods 0.000 description 4
- 235000021588 free fatty acids Nutrition 0.000 description 4
- 241000238366 Cephalopoda Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 239000000344 soap Substances 0.000 description 3
- 210000000434 stratum corneum Anatomy 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- BQPPJGMMIYJVBR-UHFFFAOYSA-N (10S)-3c-Acetoxy-4.4.10r.13c.14t-pentamethyl-17c-((R)-1.5-dimethyl-hexen-(4)-yl)-(5tH)-Delta8-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C BQPPJGMMIYJVBR-UHFFFAOYSA-N 0.000 description 2
- UPGTYLFCVNHBTN-UHFFFAOYSA-N (20Z)-cholest-5,20(22)-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CCC(C)C)C1(C)CC2 UPGTYLFCVNHBTN-UHFFFAOYSA-N 0.000 description 2
- ZBFPGLKEWSMWSG-BQNIITSRSA-N (3S,5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-ol Chemical compound CC1(C)[C@@H](O)CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@@H](CCC=C(C)C)C)CC[C@@]4(C)C3=CC[C@H]21 ZBFPGLKEWSMWSG-BQNIITSRSA-N 0.000 description 2
- CHGIKSSZNBCNDW-UHFFFAOYSA-N (3beta,5alpha)-4,4-Dimethylcholesta-8,24-dien-3-ol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21 CHGIKSSZNBCNDW-UHFFFAOYSA-N 0.000 description 2
- XYTLYKGXLMKYMV-UHFFFAOYSA-N 14alpha-methylzymosterol Natural products CC12CCC(O)CC1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C XYTLYKGXLMKYMV-UHFFFAOYSA-N 0.000 description 2
- FPTJELQXIUUCEY-UHFFFAOYSA-N 3beta-Hydroxy-lanostan Natural products C1CC2C(C)(C)C(O)CCC2(C)C2C1C1(C)CCC(C(C)CCCC(C)C)C1(C)CC2 FPTJELQXIUUCEY-UHFFFAOYSA-N 0.000 description 2
- 241000555825 Clupeidae Species 0.000 description 2
- BKLIAINBCQPSOV-UHFFFAOYSA-N Gluanol Natural products CC(C)CC=CC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3 BKLIAINBCQPSOV-UHFFFAOYSA-N 0.000 description 2
- LOPKHWOTGJIQLC-UHFFFAOYSA-N Lanosterol Natural products CC(CCC=C(C)C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 LOPKHWOTGJIQLC-UHFFFAOYSA-N 0.000 description 2
- CAHGCLMLTWQZNJ-UHFFFAOYSA-N Nerifoliol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C CAHGCLMLTWQZNJ-UHFFFAOYSA-N 0.000 description 2
- ZBFPGLKEWSMWSG-UHFFFAOYSA-N agnosterone Natural products CC1(C)C(O)CCC2(C)C3=CCC4(C)C(C(CCC=C(C)C)C)CCC4(C)C3=CCC21 ZBFPGLKEWSMWSG-UHFFFAOYSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- UPGTYLFCVNHBTN-OFAYOZIESA-N cholesta-5,22E-dien-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/CC(C)C)[C@@]1(C)CC2 UPGTYLFCVNHBTN-OFAYOZIESA-N 0.000 description 2
- 239000008406 cosmetic ingredient Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- QBSJHOGDIUQWTH-UHFFFAOYSA-N dihydrolanosterol Natural products CC(C)CCCC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 QBSJHOGDIUQWTH-UHFFFAOYSA-N 0.000 description 2
- 150000002148 esters Chemical group 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- CAHGCLMLTWQZNJ-RGEKOYMOSA-N lanosterol Chemical compound C([C@]12C)C[C@@H](O)C(C)(C)[C@H]1CCC1=C2CC[C@]2(C)[C@H]([C@H](CCC=C(C)C)C)CC[C@@]21C CAHGCLMLTWQZNJ-RGEKOYMOSA-N 0.000 description 2
- 229940058690 lanosterol Drugs 0.000 description 2
- 239000004973 liquid crystal related substance Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000007127 saponification reaction Methods 0.000 description 2
- 238000005292 vacuum distillation Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- RLHIRZFWJBOHHD-UHFFFAOYSA-N 3,5-cholestadiene Natural products C1C=C2C=CCCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 RLHIRZFWJBOHHD-UHFFFAOYSA-N 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000273930 Brevoortia tyrannus Species 0.000 description 1
- RLHIRZFWJBOHHD-HKQCOZBKSA-N Cholesta-3,5-diene Chemical compound C1C=C2C=CCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 RLHIRZFWJBOHHD-HKQCOZBKSA-N 0.000 description 1
- 241000252203 Clupea harengus Species 0.000 description 1
- 241001454694 Clupeiformes Species 0.000 description 1
- 241001149724 Cololabis adocetus Species 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 241000257465 Echinoidea Species 0.000 description 1
- 241000239366 Euphausiacea Species 0.000 description 1
- 241001313700 Gadus chalcogrammus Species 0.000 description 1
- 241000276438 Gadus morhua Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000269821 Scombridae Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 235000019513 anchovy Nutrition 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001841 cholesterols Chemical class 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 230000003648 hair appearance Effects 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 235000019514 herring Nutrition 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 235000020640 mackerel Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
Description
本発明は、乳化化粧料に関する。詳しくは、コレステロールを含有しながら、べたつきが少なく、のびが良い、使用感触の軽い乳化化粧料に関する。 The present invention relates to an emulsified cosmetic. Specifically, the present invention relates to an emulsified cosmetic that contains cholesterol, has less stickiness, has a good spread, and is light to the touch.
コレステロールはリポタンパク、生体膜の構成成分として必須であるため、ほとんどすべての動物組織中に認められる。そしてその用途は、飼料添加物、香粧品原料、液晶原料、医薬原料など多岐にわたっている。このうち香粧品原料、液晶原料、医薬原料として用いられる場合は、特に純度の高いコレステロールが要求される。
コレステロールは化粧品成分としては、油剤、エモリエント剤、皮膚コンディショニング剤、乳化剤、親油性増粘剤として使われている。角質層に潤いを与え、肌を柔らかくする成分としても、広く使用されている（特許文献１、２等）。
コレステロールとしては、羊毛脂を原料とするラノリンコレステロール、牛、豚の脳脊髄から抽出するもの、魚由来のものが知られている（特許文献３）。化粧料分野では、ラノリンコレステロールが最も広く利用されている。Cholesterol is found in almost all animal tissues because it is an essential component of lipoproteins and biological membranes. Its uses range from feed additives, cosmetic ingredients, liquid crystal ingredients, pharmaceutical ingredients, and so on. Among these, when used as a cosmetic raw material, a liquid crystal raw material, or a pharmaceutical raw material, cholesterol with particularly high purity is required.
Cholesterol is used as a cosmetic ingredient as an oil, emollient, skin conditioning agent, emulsifier, and lipophilic thickener. It is also widely used as a component that moisturizes the stratum corneum and softens the skin (Patent Documents 1, 2, etc.).
As cholesterol, lanolin cholesterol using wool oil as a raw material, those extracted from the cranial spinal cord of cattle and pigs, and those derived from fish are known (Patent Document 3). Lanolin cholesterol is most widely used in the cosmetics field.
本発明は、コレステロールを含有しながら、べたつきがなくさらっとした軽い使用感触の、乳化タイプの化粧料を提供することを課題とする。コレステロールは角質層に潤いを与え、肌を柔らかくする成分としてクリームなどに用いられる。しっとりするのは良いが、使用時にべたつきがあると感じられることがあり、さっぱりした使用感に仕上げたい化粧料には添加しにくい場合があった。 An object of the present invention is to provide an emulsification type cosmetic material that contains cholesterol, has no stickiness and is light and easy to use. Cholesterol is used in creams and the like as a component that moisturizes the stratum corneum and softens the skin. Although it is good to be moist, it sometimes feels sticky during use, and it may be difficult to add it to cosmetics that want a refreshing feel.
化粧品に用いられるコレステロールはほとんどが、ラノリン由来のコレステロールである。本願はあまり利用されていなかった魚由来のコレステロールの性質を調べる中で、主成分は同じコレステロールであるが、由来が異なるとその物性に差があることを見出し、本発明を完成させた。
本発明は、下記の（１）〜（５）の乳化化粧料を要旨とする。
（１）コレステロールとして、魚由来のコレステロールであって、コレステロールの含有率が９３〜９６面積％であるものを含有することを特徴とする乳化化粧料。
（２）魚由来のコレステロールが粗魚油に含まれるコレステロールを蒸留にて分取し、ヘキサンにてコレステロールを９３〜９６面積％の純度で含有するように精製したものである（１）の乳化化粧料。
（３）魚由来のコレステロールにコレステロール以外に含まれる成分のうち、１面積％以上含まれる成分が２４−メチレンコレステロールである（１）又は（２）の乳化化粧料。
（４）魚由来のコレステロールがイワシ由来のコレステロールである（１）ないし（３）いずれかの乳化化粧料。
（５）ラノリン由来のステロール成分を含有しないものである（１）ないし（４）いずれかの乳化化粧料。
本発明において、面積％とは、コレステロールと他のステロールの混合物である魚由来コレステロールをガスクロマトグラフィーを用いて分析したチャートのそれぞれの成分のピーク面積の全ピーク面積に対する割合で、そのピークの成分の含有比率を示すものである。Most of the cholesterol used in cosmetics is lanolin-derived cholesterol. While the present application investigated the properties of cholesterol derived from fish that was not widely used, the main component was the same cholesterol, but when the origin was different, it was found that there was a difference in physical properties, and the present invention was completed.
The gist of the present invention is the emulsified cosmetics of the following (1) to (5).
(1) An emulsified cosmetic comprising a fish-derived cholesterol having a cholesterol content of 93 to 96 area% as cholesterol.
(2) The emulsified makeup according to (1), wherein cholesterol derived from fish is obtained by fractionating cholesterol contained in crude fish oil by distillation, and purifying cholesterol with a purity of 93 to 96 area% with hexane. Fee.
(3) The emulsified cosmetic according to (1) or (2), wherein a component contained in the fish-derived cholesterol other than cholesterol in an amount of 1 area% or more is 24-methylene cholesterol.
(4) The emulsified cosmetic according to any one of (1) to (3), wherein the cholesterol derived from fish is cholesterol derived from sardines.
(5) The emulsified cosmetic according to any one of (1) to (4), which does not contain a lanolin-derived sterol component.
In the present invention, area% is the ratio of the peak area of each component of the chart obtained by analyzing fish-derived cholesterol, which is a mixture of cholesterol and other sterols, using gas chromatography to the total peak area, and the component of the peak The content ratio of is shown.
本発明によれば、化粧料の成分としてコレステロールを配合しても、従来よりも、べたつきがなく肌の上でのびが良く、軽い使用感の、乳化タイプの化粧料を得ることができる。 According to the present invention, even when cholesterol is blended as a component of a cosmetic, it is possible to obtain an emulsified cosmetic that is less sticky and has a better spread on the skin and has a light feeling of use.
本発明において、魚由来コレステロールとは、魚類から得られるコレステロールである。通常、魚油の精製工程においてコレステロール画分を得、それを精製することによって得られる。
魚油原料からコレステロールを得る方法としては、魚油を水酸化ナトリウム等のアルカリ水溶液と混合後、遠心分離して得られる石鹸層を原料とする方法がある。石鹸層を酸で中和して油層を分取し、これに含まれる脂肪酸やグリセリドをメチルエステル化した後、分子蒸留によって除去し、この残留物からメタノール等の有機溶剤を用いて再結晶を行ってコレステロールを分離精製する方法や、石鹸層からヘキサン、シクロヘキサン等の有機溶剤によってコレステロール含有画分を抽出し、シリカゲルなどのカラムによりコレステロールを精製する方法である。In the present invention, fish-derived cholesterol is cholesterol obtained from fish. Usually, it is obtained by obtaining a cholesterol fraction in the purification process of fish oil and purifying it.
As a method for obtaining cholesterol from a fish oil raw material, there is a method using a soap layer obtained by mixing fish oil with an aqueous alkali solution such as sodium hydroxide and then centrifuging as a raw material. The soap layer is neutralized with acid to separate the oil layer, and fatty acids and glycerides contained in the oil layer are converted to methyl ester, then removed by molecular distillation, and the residue is recrystallized using an organic solvent such as methanol. This is a method for separating and purifying cholesterol, or a method for extracting cholesterol-containing fractions from a soap layer with an organic solvent such as hexane and cyclohexane, and purifying cholesterol using a column such as silica gel.
あるいは、魚油原料を分子蒸留し、得られた揮発性成分をヘキサン、メタノール、アセトン、酢酸エチルなどの溶剤で結晶化する方法で得る方法もある。この方法は、まず魚油原料を分子蒸留し、揮発成分を得る。魚油としては、煮取法、圧搾法、アルカリ分解法、自己消化法、溶剤抽出法等通常の採油方法により得たものが好ましく、特に公知の手段により脱ガム処理されているものが好ましい。また、魚油の原料魚としては、イワシ、サバ、サンマ、ニシン、メンヘーデン、スケトウダラ、マダラ等の魚類、オキアミ等の甲殻類、スルメイカ、ムラサキイカ等の頭足類などが例示される。
本発明においてイワシとは、マイワシ属、ウルメイワシ属、カタクチイワシ属および、マイワシ属と合わせてマイワシ類とされるサルディナ属を加えた4属に分類され、一般に「マイワシ」「ウルメイワシ」「カタクチイワシ」として扱われている魚の総称として用いている。
分子蒸留は薄膜流下式、遠心式等の装置を用い、真空度１×１０−３〜１×１０−２ｍｍHgで、温度200〜250℃で加熱する条件で行われる。この分子蒸留工程では、脂肪酸や臭気成分とともに、魚油中の主要不ケン化物であるコレステロールが効率よく揮発性留分に凝縮される。次に、得られた揮発性成分を、溶剤を用いて結晶化せしめる。結晶化に用いられる溶剤としては、ヘキサン、メタノール、アセトン、酢酸エチル等の有機溶剤が挙げられる。Alternatively, there is a method in which a fish oil raw material is molecularly distilled and the obtained volatile component is crystallized with a solvent such as hexane, methanol, acetone, ethyl acetate, or the like. In this method, first, a fish oil raw material is molecularly distilled to obtain a volatile component. The fish oil is preferably obtained by a normal oil collecting method such as a cooking method, a pressing method, an alkali decomposition method, a self-digestion method or a solvent extraction method, and particularly preferably one that has been degummed by known means. Examples of fish oil raw fish include fish such as sardine, mackerel, saury, herring, menhaden, walleye pollock, and cod shellfish, crustaceans such as krill, and cephalopods such as squid and squid.
In the present invention, sardines are classified into four genera including the sardine genus, the urchin eagle genus, the anchovy genus, and the genus sardine, which is a sardine in combination with the sardine genus. It is used as a general term for fish.
Molecular distillation is performed under conditions of heating at a temperature of 200 to 250 ° C. with a vacuum of 1 × 10 −3 to 1 × 10 −2 mmHg using an apparatus such as a thin film flow type or a centrifugal type. In this molecular distillation step, together with fatty acids and odor components, cholesterol, which is the main unsaponified product in fish oil, is efficiently condensed into a volatile fraction. Next, the obtained volatile component is crystallized using a solvent. Examples of the solvent used for crystallization include organic solvents such as hexane, methanol, acetone, and ethyl acetate.
本発明のコレステロールとして好ましいのは、粗魚油に含まれるコレステロールを蒸留にて分取し、ヘキサンにてコレステロールを９３〜９６面積％の純度で含有するように精製したものである。具体的には、イワシなどの粗魚油を水洗し脱水した後、短行程真空蒸留装置により、遊離脂肪酸、コレステロールを主成分とする蒸留成分を得る。続いて、この蒸留成分を分子蒸留にかけ、遊離脂肪酸を蒸留成分として除去し、コレステロールを残渣として得る。コレステロールはフリー体のものとエステル体のものとが混ざっているので、ケン化反応を行い、フリー体に統一させる。コレステロールをヘキサン抽出し結晶化させ、ヘキサンを溶媒として再結晶することにより９３〜９６面積％の純度のコレステロールが得られる。
この方法により、工業規模でも純度９３〜９６面積％のコレステロールを得ることができる。本方法により得られた魚由来ステロールには、コレステロール以外に、cholesta-3,5-diene, 24-methylenecholesterol, 22-dehydrocholesterolなどのステロール類が含まれる。実施例のイワシ油の場合、他の成分のうち、1面積％以上含まれていたのは、24-methylenecholesterolのみであった。
化粧品に広く用いられる、ラノリンコレステロールでは、コレステロール以外に含まれるステロール類として主なものはラノステロール、アグノステロールであることが知られている。
同じコレステロールを主成分とするものであるが、ラノリン由来のコレステロールと魚由来のコレステロールでは副成分の組成が異なるため、その物性に差があるものと考えられる。したがって、本発明のコレステロールはラノリン由来のステロール類、例えば、ラノステロール、アグノステロールを実質的に含まないものである。Preferable cholesterol for use in the present invention is a product obtained by fractionating cholesterol contained in crude fish oil by distillation and purifying it with hexane so as to contain cholesterol with a purity of 93 to 96 area%. Specifically, crude fish oil such as sardine is washed with water and dehydrated, and then a distillation component mainly composed of free fatty acid and cholesterol is obtained by a short stroke vacuum distillation apparatus. Subsequently, this distillation component is subjected to molecular distillation, free fatty acids are removed as a distillation component, and cholesterol is obtained as a residue. Cholesterol is a mixture of a free form and an ester form, so a saponification reaction is performed to unify the free form. Cholesterol is extracted with hexane, crystallized, and recrystallized using hexane as a solvent to obtain cholesterol having a purity of 93 to 96 area%.
By this method, cholesterol having a purity of 93 to 96 area% can be obtained even on an industrial scale. The fish-derived sterols obtained by this method include sterols such as cholesta-3,5-diene, 24-methylenecholesterol, 22-dehydrocholesterol in addition to cholesterol. In the case of the sardine oil of the example, only 24-methylenecholesterol contained 1 area% or more among other components.
In lanolin cholesterol widely used in cosmetics, it is known that the main sterols contained in addition to cholesterol are lanosterol and agnosterol.
Although it has the same cholesterol as the main component, it is considered that there is a difference in physical properties between cholesterol derived from lanolin and cholesterol derived from fish because the composition of subcomponents is different. Therefore, the cholesterol of the present invention is substantially free of lanolin-derived sterols such as lanosterol and agnosterol.
本発明では、従来ラノリンコレステロールが用いられていた化粧料のコレステロールとして、魚由来コレステロールを用いて物性について詳細に検討したところ、使用感に違いがあることを見出した。ラノリンコレステロールの方がやや油っぽく、重みがある使用感で、魚由来コレステロールの方は、べとつき感が少なく、軽い使用感であった。どちらがいいというよりも好みや使用目的によって使い分けるのが好ましいと考えられる。
コレステロール自体は同じなので、コレステロールの角質層に潤いを与え、肌を柔らかくするという機能は維持したまま、適宜、ラノリンコレステロールと魚由来コレステロールを使い分けることにより、最終商品である化粧料の使用感に影響を与えることができる。
本発明の魚由来コレステロールは使用感以外の点においては、ラノリンコレステロールと全く同じものとして利用できるので、使用目的、使用方法、使用量などについては、従来化粧料の分野で用いられているコレステロールと全く同等に用いればよい。In the present invention, when physical properties were examined in detail using fish-derived cholesterol as cosmetic cholesterol for which lanolin cholesterol was conventionally used, it was found that there was a difference in usability. Lanolin cholesterol is slightly oily and has a heavy feeling, and fish-derived cholesterol has a lighter feeling with less stickiness. Rather than which is better, it is preferable to use them properly according to taste and purpose of use.
Cholesterol itself is the same, so the use of lanolin cholesterol and fish-derived cholesterol properly affects the feeling of use of the final product cosmetic, while maintaining the functions of moisturizing the stratum corneum of cholesterol and softening the skin. Can be given.
Since the fish-derived cholesterol of the present invention can be used as the same as lanolin cholesterol except for the feeling of use, the use purpose, the method of use, the amount of use, etc. are the same as those conventionally used in the cosmetics field. It may be used exactly the same.
本発明において乳化化粧料とは、油脂と水分を含有し乳化された化粧品等を意味し、具体的には、保湿クリーム、マッサージクリーム、クレンジングクリーム、エッセンス等のスキンケア化粧料、ヘアクリーム等のヘアケア化粧料、サンスクリーン、ボディクリーム等のボデイケア化粧料、ゲル状ファンデーション等のリンス等の洗浄料等、可能なすべての化粧料に利用することができる。
魚由来のコレステロールは、最終商品である化粧料に通常使われる量のコレステロール量を用いればよい。具体的には0.1〜10重量％含有するのが好ましい。
本発明のコレステロールは、ラノリン由来のものに比べて、使用感が重くなりにくいので、べとつきなどが少なく使用感は軽いにもかかわらず、しっとりさせる効果がある化粧料を提供することができる。また、ウェーブヘア用とストレートヘア用があるヘアトリートメントでは、ストレートヘア用に用いるのが好ましい。In the present invention, the emulsified cosmetic means an emulsified cosmetic containing fats and oils, specifically, skin care cosmetics such as moisturizing cream, massage cream, cleansing cream, essence, and hair care such as hair cream. It can be used for all possible cosmetics such as cosmetics, body care cosmetics such as sunscreens and body creams, and rinses such as rinses such as gel foundations.
As for cholesterol derived from fish, the amount of cholesterol usually used in cosmetics as final products may be used. Specifically, the content is preferably 0.1 to 10% by weight.
Since the cholesterol of the present invention is harder to use than the lanolin-derived cholesterol, it is possible to provide a cosmetic that has a moisturizing effect although it is less sticky and has a light usability. In addition, in hair treatments for wave hair and for straight hair, it is preferably used for straight hair.
以下に本発明の実施例を記載するが、本発明はこれらに何ら限定されるものではない。
魚由来コレステロールの製造
本実施例で用いた魚由来コレステロールは、以下の製法で製造した。
イワシの粗魚油を水洗し脱水した後、短行程真空蒸留装置により、遊離脂肪酸、コレステロールを主成分とする蒸留成分を得る。トリグリセリドを主成分とする魚油本体は残渣として別途利用される。続いて、この蒸留成分を分子蒸留にかけ、遊離脂肪酸を蒸留成分として除去し、コレステロールを残渣として得る。コレステロールはフリー体のものとエステル体のものとが混ざっているので、ケン化反応を行い、フリー体に統一させる。コレステロールをヘキサン抽出し結晶化させ、ヘキサンを溶媒として再結晶することにより９３〜９６面積％の純度のコレステロールが得られる。
得られたコレステロールを０．５ｍｇ／ｍｌの濃度でヘキサンに溶解し、下記の条件でガスクロマトグラフィーを用いて分析した結果、コレステロール含有率は94.8面積％であり、他のステロール成分として、cholesta-3,5-diene、24-methylenecholesterol、22-dehydrocholesterolなどを含有するものであった。他の成分のうち、1面積％以上含まれていたのは、24-methylenecholesterolのみであった。
ガスクロマトグラフィー分析条件
ガスクロマトグラフ：Agilent 6850
検出器：水素イオン型検出器
カラム：DB-1HT（J＆W） 長さ15ｍ×内径0.25mm×厚さ0.10μm
注入口温度：280℃
オーブン温度：150℃−(3℃/分)−260℃−(15℃/分)−320℃−(3℃/分)−350℃(10分間)
検出器温度：280℃
カラム流量：1ml/min（コンスタントフロー）
キャリアガス：ヘリウム
水素流量：40ml/min
Air流量：450ml/min
メークアップ流量：24 ml/min（窒素ガス）
注入モード：スプリット（30:1）
注入量：1μlExamples of the present invention will be described below, but the present invention is not limited thereto.
Production of fish-derived cholesterol The fish-derived cholesterol used in this Example was produced by the following production method.
After sardine crude fish oil is washed with water and dehydrated, a distillation component mainly composed of free fatty acids and cholesterol is obtained by a short stroke vacuum distillation apparatus. The fish oil body mainly composed of triglyceride is separately used as a residue. Subsequently, this distillation component is subjected to molecular distillation, free fatty acids are removed as a distillation component, and cholesterol is obtained as a residue. Cholesterol is a mixture of a free form and an ester form, so a saponification reaction is performed to unify the free form. Cholesterol is extracted with hexane, crystallized, and recrystallized using hexane as a solvent to obtain cholesterol having a purity of 93 to 96 area%.
The obtained cholesterol was dissolved in hexane at a concentration of 0.5 mg / ml, and analyzed by gas chromatography under the following conditions. As a result, the cholesterol content was 94.8 area%, and as other sterol components, It contained 3,5-diene, 24-methylenecholesterol, 22-dehydrocholesterol and the like. Among the other components, only 24-methylenecholesterol contained 1 area% or more.
Gas chromatographic analysis conditions <br/> Gas chromatograph: Agilent 6850
Detector: Hydrogen ion type detector Column: DB-1HT (J & W) Length 15m x Inner diameter 0.25mm x Thickness 0.10μm
Inlet temperature: 280 ℃
Oven temperature: 150 ° C-(3 ° C / min)-260 ° C-(15 ° C / min)-320 ° C-(3 ° C / min)-350 ° C (10 min)
Detector temperature: 280 ° C
Column flow rate: 1 ml / min (constant flow)
Carrier gas: Helium Hydrogen flow rate: 40ml / min
Air flow rate: 450ml / min
Makeup flow rate: 24 ml / min (nitrogen gas)
Injection mode: Split (30: 1)
Injection volume: 1μl
魚由来コレステロールとラノリンコレステロールの比較試験（フェイスクリーム）
表１に示す配合でコレステロール配合フェイスクリームを調製した。表１のコレステロールとして、実施例１で製造した魚由来コレステロールを用いたもの（本発明クリーム）とラノリンコレステロール（製品名：コレステロール（JSCI）、製造元：日本精化株式会社）を用いたもの（比較クリーム）の２種類を調製した。 Comparison test of fish-derived cholesterol and lanolin cholesterol (face cream)
Cholesterol-blended face cream was prepared with the formulation shown in Table 1. As cholesterol of Table 1, what used the fish origin cholesterol manufactured in Example 1 (this invention cream) and lanolin cholesterol (Product name: Cholesterol (JSCI), manufacturer: Nippon Seika Co., Ltd.) (comparison) Two types of cream) were prepared.
３０〜５０歳代のボランティアの女性３２名に、本発明クリームと比較クリームをそれぞれ６日間使用してもらい、その後、使用感等についてアンケートに回答してもらった。１回の使用量は約０．３ｇ（真珠粒大）を顔全体に、通常使用しているクリームの代わりに使用してもらった。
アンケートの内容は、「肌に伸ばすときの感触」、「肌に伸ばした直後の感触」、「使用１時間後の感触」、「継続使用後の感触」について、「１．良い、２．やや良い、３．ふつう、４．やや悪い、５．悪い」のような５段階評価、あるいは、「滑らか、みずみずしい、軽やか、コクがある、密着感がある、油っぽい、厚ぼったい（被覆感）、上滑りする、重い、その他」のようなリストから使用感を選択してもらう形で行った。Thirty-two volunteers in their 30s to 50s used the cream of the present invention and the comparative cream for 6 days, respectively, and then answered a questionnaire about the feeling of use. The amount used per time was about 0.3 g (pearl size) for the entire face instead of the usual cream.
The contents of the questionnaire are as follows: “1. Good, 2. Slightly feel after stretching”, “Feel immediately after stretching”, “Feel after 1 hour”, “Feel after continued use” Good, 3. Normal, 4. Slightly bad, 5. Bad, etc., or “Smooth, fresh, light, rich, sticky, oily, thick (coating), It was done in the form of having usability selected from a list such as “sliding, heavy, etc.”.
アンケートの結果、ほとんどの項目に大きな差は認められなかったが、一部の項目に特徴的な差が認められた。ひとつは、「肌に伸ばすときの感触」である。図１に示すように、本発明クリームでは、「みずみずしい、軽やか」との評価が高いのに対し、比較クリームでは「滑らか、密着感がある」との評価が高かった。
また、「肌に伸ばした直後の感触」においても、図２に示すように、本発明クリームでは、「みずみずしい、すべすべしている」との評価が高いのに対し、比較クリームでは「しっとりしている」との評価が高かった。
本発明クリームと比較クリームはコレステロールの由来が異なる以外は、全く同じ配合で製造したものであり、これらの相違点が見られたのは予想外の結果であった。わずかに含まれる主成分以外の成分の影響ではないかと考えられる。使用１時間後や翌朝の感触においては、大きな差は見られなくなることから、これらのクリームの実効性にはほとんど差がなく、使用感のみに差が見られる。化粧品の目的に応じて使い分けることが可能だと考えられる。As a result of the questionnaire, there was no big difference in most items, but there was a characteristic difference in some items. One is “feel when stretched to the skin”. As shown in FIG. 1, the cream according to the present invention has a high evaluation of “fresh and light”, whereas the comparative cream has a high evaluation of “smooth and close”.
In addition, in the “feel immediately after being stretched on the skin”, as shown in FIG. 2, the cream of the present invention is highly evaluated as “fresh and smooth”, whereas the comparative cream is “moist. It was highly rated.
The cream of the present invention and the comparative cream were produced with exactly the same composition except that the origin of cholesterol was different, and it was an unexpected result that these differences were seen. It is thought that it is the influence of components other than the main component contained slightly. There is almost no difference in the effectiveness of these creams, and there is a difference only in the feeling of use since there is no significant difference in the feeling after 1 hour of use or in the next morning. It is thought that it can be used properly according to the purpose of cosmetics.
魚由来コレステロールとラノリンコレステロールの比較試験（ヘアトリートメント）
表２に示す配合でコレステロール配合ヘアトリートメントを調製した。表２のコレステロールとして、実施例１で製造した魚由来コレステロールを用いたもの（本発明トリートメント）とラノリンコレステロール（製品名：コレステロール（JSCI）、製造元：日本精化株式会社）を用いたもの（比較トリートメント）の２種類を調製した。 Comparison test of fish-derived cholesterol and lanolin cholesterol (hair treatment)
Cholesterol-blended hair treatments were prepared with the formulations shown in Table 2. As the cholesterols in Table 2, those using fish-derived cholesterol produced in Example 1 (treatment of the present invention) and those using lanolin cholesterol (product name: cholesterol (JSCI), manufacturer: Nippon Seika Co., Ltd.) (comparison) Two types of treatment) were prepared.
３０〜５０歳代のボランティアの女性３２名に、本発明トリートメントと比較トリートメントをそれぞれ６日間使用してもらい、その後、使用感等についてアンケートに回答してもらった。１回の使用量はショートヘアの場合、大さじ１杯くらい、ロングヘアの場合大さじ２杯くらいを目安に髪全体にシャンプー後に使用してもらった。
アンケートの内容は、「髪に伸ばすときの感触」、「洗い流した後の髪の感触」、「ドライヤーで乾かした後の感触」、「乾かした１時間後の感触」、「継続使用後の感触」について、「１．良い、２．やや良い、３．ふつう、４．やや悪い、５．悪い」のような５段階評価、あるいは、「滑らか、みずみずしい、指どおりがよい、さらさらしている、つるつるしている、しっとりしている、油っぽい、ベタつく、厚ぼったさ（被覆感）を感じる、重い、なじみが悪い、その他」のようなリストから使用感を選択してもらう形で行った。Thirty-two volunteer women in their 30s and 50s used the treatment of the present invention and the comparative treatment for 6 days respectively, and then asked them to answer a questionnaire about their feeling of use. The amount used once was about 1 tablespoon for short hair, and about 2 tablespoons for long hair.
The contents of the questionnaire are "feel when extending to hair", "feel of hair after washing off", "feel after drying with a dryer", "feel after drying for 1 hour", "feel after continuous use" ”Is a five-point evaluation such as“ 1. Good, 2. Moderately good, 3. Normal, 4. Moderately bad, 5. Poor ”, or“ Smooth, fresh, good to follow, smooth, It is done in the form of having a feeling of use selected from a list such as “smooth, moist, oily, sticky, thick (feeling of covering), heavy, unfamiliar, etc.” It was.
アンケートの結果、ほとんどの項目に大きな差は認められなかったが、一部の項目に特徴的な差が認められた。ひとつは、「髪に伸ばすときの感触」である。図３に示すように、本発明トリートメントでは、「みずみずしい、さらさら」との評価が高いのに対し、比較トリートメントでは「滑らか、指どおりがよい、しっとり」との評価が高かった。
「洗い流した後の髪の感触」においても、図４に示すように、本発明トリートメントでは、「柔らか、さっぱり」との評価が高いのに対し、比較トリートメントでは「しっとり、滑らか、さらさら、指どおりがよい」との評価が高かった。
また、「ドライヤーで乾かした後の髪の感触」においても、図５に示すように、本発明トリートメントでは、「さらさら、指どおりがよい、パサつく」との評価が高いのに対し、比較トリートメントでは「しっとり、滑らか、さらさら、まとまらない」との評価が高かった。
特に、ストレートヘアのモニターにおいて、評価が高かった。
本発明トリートメントと比較トリートメントはコレステロールの由来が異なる以外は、全く同じ配合で製造したものであり、これらの相違点が見られたのは予想外の結果であった。わずかに含まれる主成分以外の成分の影響ではないかと考えられる。乾わかした１時間後や翌朝の感触においては、大きな差は見られなくなることから、これらのトリートメントの実効性にはほとんど差がなく、使用感のみに差が見られる。髪用化粧料は髪質によって、望まれる効果が異なるので使用目的に応じて使い分けることが可能だと考えられる。As a result of the questionnaire, there was no big difference in most items, but there was a characteristic difference in some items. One is “feel when extending to hair”. As shown in FIG. 3, in the treatment of the present invention, the evaluation of “fresh, smooth” was high, whereas in the comparative treatment, the evaluation of “smooth, good to touch, moist” was high.
As shown in Fig. 4, in the "feel of the hair after washing off", the treatment of the present invention is highly evaluated as "soft and refreshing", whereas the comparative treatment is "moist, smooth, smooth and smooth. “Good” was high.
Also, in the “feel of hair after drying with a dryer”, as shown in FIG. 5, the treatment according to the present invention has a high evaluation of “smooth, good to follow your finger, and dry”. Then, “Moist, smooth, smooth, untidy” was highly evaluated.
In particular, the evaluation was high in the straight hair monitor.
The treatment according to the present invention and the comparative treatment were produced with exactly the same composition except that the origin of cholesterol was different, and it was an unexpected result that these differences were observed. It is thought that it is the influence of components other than the main component contained slightly. There is almost no difference in the effectiveness of these treatments, only in the feeling of use, since there is no significant difference in the feel after 1 hour of drying or the next morning. Since hair cosmetics have different desired effects depending on the quality of the hair, it is thought that they can be used according to the purpose of use.
各種化粧料の成分としてコレステロールを用いる場合に、目的とする化粧料の使用感をしっかりしたタイプにしたいか軽いタイプにしたいかなどによって、ラノリンコレステロールと魚由来のコレステロールを使い分けることができる。 When cholesterol is used as a component of various cosmetics, lanolin cholesterol and fish-derived cholesterol can be selectively used depending on whether the intended cosmetic use feeling is to be solid or light.
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| KR20190098716A (en) * | 2018-02-14 | 2019-08-22 | 로하스 알레한드로 마르코비츠 | Fish oil cholesterol |
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| KR102091463B1 (en) | 2012-11-02 | 2020-03-23 | 프로노바 바이오파마 노르지 에이에스 | Method for removing undesired components from oil compositions |
| US9655821B2 (en) | 2013-04-05 | 2017-05-23 | The Procter & Gamble Company | Personal care composition comprising a pre-emulsified formulation |
| US10806688B2 (en) | 2014-10-03 | 2020-10-20 | The Procter And Gamble Company | Method of achieving improved volume and combability using an anti-dandruff personal care composition comprising a pre-emulsified formulation |
| US9993404B2 (en) | 2015-01-15 | 2018-06-12 | The Procter & Gamble Company | Translucent hair conditioning composition |
| WO2017127344A1 (en) | 2016-01-20 | 2017-07-27 | The Procter & Gamble Company | Hair conditioning composition comprising monoalkyl glyceryl ether |
| US10190074B1 (en) * | 2018-02-14 | 2019-01-29 | Golden Omega S.A. | Composition comprising cholesterol |
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