JP5802034B2 - Syringe - Google Patents

Description

  The present invention relates to a syringe.

  The syringe is generally composed of an outer cylinder, a gasket that can slide in the outer cylinder, and a plunger that moves the gasket. Moreover, the outer cylinder has a trunk | drum and the reduced diameter part (mouth part) which was provided in the front end side of the trunk | drum and diameter-reduced with respect to the trunk | drum. Such a syringe is configured to move the gasket toward the distal end side by pushing the pusher into the outer cylinder, thereby guiding the chemical stored in the outer cylinder to the outside of the outer cylinder from the opening of the mouth. (For example, refer to Patent Document 1).

  In the syringe described in Patent Document 1, even if the pusher is pushed in and pushed to a position where the gasket cannot be substantially moved, the gasket cannot enter the reduced diameter portion of the outer cylinder. Therefore, a relatively large amount of chemical solution remains inside the reduced diameter portion. Due to the remaining of the chemical solution, the chemical solution cannot be used efficiently, resulting in a problem of high costs. Such a problem is particularly noticeable when the chemical solution is expensive.

  If the internal space is reduced by reducing the inner diameter of the reduced diameter portion, the above-described problem may be solved, but such a method causes the following problem. That is, since the outer diameter of the reduced diameter portion is determined in order to fit the hub, connector, etc. of the needle tube, in order to reduce the internal space of the reduced diameter portion, the thickness of the reduced diameter portion is increased. There is a need to. However, when the thickness of the reduced diameter portion is increased by injection molding, sinking occurs in the thick portion at the time of molding, resulting in a problem that the fitting with the needle hub and connectors cannot be ensured.

  Moreover, although the above-mentioned problem may be able to be solved also by making a gasket into the shape which can penetrate | invade in the internal space of a reduced diameter part, the following problems arise in such a method. That is, the gasket needs to have a shape corresponding to the internal space of the reduced diameter portion, which increases the manufacturing cost of the gasket. In addition, in order to surely allow the gasket to enter the internal space of the reduced diameter portion, exact alignment is necessary, which increases the manufacturing cost of the syringe. Furthermore, if the gasket is deformed due to some influence (for example, aged deformation or contact with the inner wall of the outer cylinder) and cannot enter the inner space of the reduced diameter portion, the gasket is more proximal than the predetermined position. Instead of using up the chemical solution in the syringe, more chemical solution remains. That is, the problem that the reliability and safety | security of a syringe fall arises.

JP 2004-162761 A

  The objective of this invention is providing the syringe which can suppress the residual of a chemical | medical solution, ensuring reliability and safety | security.

Such an object is achieved by the present inventions (1) to (7) below.
(1) An outer cylinder that has a bottom portion and a mouth portion that communicates with the bottom portion and has a mouth portion through which liquid can enter and exit at the tip end side, and is formed with a substantially uniform overall thickness.
A gasket that can slide in the outer cylinder;
A syringe connected to the gasket and provided with a pusher for moving the gasket in the longitudinal direction of the outer cylinder;
A tip member disposed on the inside of the outer cylinder and having a flow path for the liquid communicating between the inside and outside of the outer cylinder;
The distal end member has a distal end portion located inside the mouth portion, and a proximal end portion located inside the trunk portion,
The base end portion covers the bottom portion of the barrel portion and is in contact with an inner peripheral surface of the barrel portion .

(2) The syringe according to (1), wherein the volume of the flow path is 1 μL to 30 μL.
(3) The tip member has a through hole penetrating the proximal end surface and the tip surface of the tip member, and the inside of the through hole constitutes the flow path. ).

  (4) The said front-end | tip member is press-fitted in the said outer cylinder from the opening of the base end side of the said outer cylinder, The displacement to the front end side with respect to the said outer cylinder is controlled. (1) thru | or (3) The syringe according to any one of the above.

  (5) The syringe according to any one of (1) to (3), wherein the distal end member is press-fitted into the outer cylinder from an opening on the distal end side of the outer cylinder.

(6) The base end portion of the tip member is formed with a concave portion having a substantially conical concave shape,
The syringe according to any one of (1) to (5), wherein the through hole is open to a bottom portion of the recess.

(7) The tip member is formed by injection molding,
The syringe according to any one of the above (1) to (6), wherein sink marks that may be generated in the tip member by the injection molding are located at a location where the liquid does not contact the liquid.

  ADVANTAGE OF THE INVENTION According to this invention, the syringe which can suppress the residual of a chemical | medical solution can be provided, ensuring reliability and safety | security. Specifically, by providing the tip member inside the mouth, the internal space of the mouth where the gasket cannot enter is reduced, so the remaining amount of the chemical in the syringe when the pusher is fully pushed is reduced. Can be less. In particular, according to such a configuration, since the thickness of the mouth can be reduced, it is possible to effectively prevent the occurrence of sink marks and the like, and to ensure the safety of the syringe.

  Further, according to the present invention, since it is not necessary to allow the gasket to penetrate into the mouth, there is no strictness more than necessary for the shape and alignment of the gasket, and the manufacture of the syringe is facilitated. Furthermore, the problem that the remaining amount of the chemical solution increases without the gasket entering the mouth cannot occur. That is, a highly reliable and safe syringe can be provided.

It is a longitudinal cross-sectional view which shows 1st Embodiment of the syringe of this invention. It is a longitudinal cross-sectional view which shows 1st Embodiment of the syringe of this invention. It is sectional drawing for demonstrating an example of the manufacturing method of the front-end | tip member which the syringe shown in FIG. 1 has. It is a longitudinal cross-sectional view which shows 2nd Embodiment of the syringe of this invention. It is a longitudinal cross-sectional view which shows 3rd Embodiment of the syringe of this invention.

Hereinafter, the syringe of this invention is demonstrated in detail based on suitable embodiment shown to an accompanying drawing.
<First Embodiment>
First, a first embodiment of the syringe of the present invention will be described.

  FIG. 1 and FIG. 2 are longitudinal sectional views showing a first embodiment of the syringe of the present invention, respectively. FIG. 3 is a sectional view for explaining an example of a method for producing a tip member of the syringe shown in FIG. is there. Hereinafter, for convenience of explanation, the upper side in FIGS. 1 and 2 is referred to as a “base end” and the lower side is referred to as a “tip”.

  A syringe 1 shown in FIG. 1 is a prefilled syringe in which a chemical solution 100 is stored in advance inside a syringe. Such a syringe 1 includes an outer cylinder 2, a tip member 5 provided in the outer cylinder 2, a gasket 3 that can slide in the outer cylinder 2, and a pusher (plunger rod) that moves the gasket 3. 4 is provided.

  In the syringe 1, a drug solution 100 is stored in advance in a space 11 that is surrounded by the outer cylinder 2 and the gasket 3 and that is positioned on the distal end side of the gasket 3.

  Specific examples of the drug solution 100 include, for example, protein drugs such as antibodies, low molecular weight proteins, peptide drugs such as hormones, nucleic acid drugs, cell drugs, blood products, vaccines for preventing various infectious diseases, anticancer agents, Anesthetics, antibiotics, steroids, protease inhibitors, heparin, glucose injections such as glucose, electrolyte correction injections such as sodium chloride and potassium lactate, vitamins, fat emulsions, contrast agents, etc. .

Hereinafter, each site | part of the syringe 1 is demonstrated in detail sequentially.
-Outer cylinder-
The outer cylinder 2 is composed of a bottomed cylindrical member. Such an outer cylinder 2 has a trunk portion 21 having a bottom portion 211 and a reduced diameter portion 22 which is provided at the center of the bottom portion 211 and has a diameter reduced with respect to the trunk portion 21, and these are integrally formed. Is formed. The reduced diameter portion 22 forms a mouth portion through which liquid can enter and exit.

  Further, for example, a hub of a needle tube, connectors, and the like are fitted to and attached to the reduced diameter portion 22. The cross-sectional shape of the lumen 23 of the reduced diameter portion 22 is circular, and its cross-sectional area gradually decreases toward the distal end side. That is, the lumen 23 of the present embodiment has a truncated cone shape.

  In addition, it is preferable that the thickness from the bottom part 211 to the front-end | tip part of the reduced diameter part 22 is substantially uniform. The thickness is preferably 0.5 to 1.5 mm when the reduced diameter portion 22 is a Luer taper, and is preferably 0.5 to 3 mm in other cases. Thereby, when the outer cylinder 2 is injection-molded, sink marks are not generated from the bottom portion 211 to the reduced diameter portion 22.

  As a sealing member, for example, a film (not shown) is attached or a cap (not shown) is attached to the tip of the reduced diameter portion 22, and the lumen 23 of the reduced diameter portion 22 is hermetically sealed. doing.

  A plate-like flange 27 is formed on the outer periphery of the base end of the outer cylinder 2. When the pusher 4 is moved relative to the outer cylinder 2, the operation can be performed by placing a finger on the flange 27.

  As a constituent material of the outer cylinder 2, for example, polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin such as cyclic olefin homopolymer (COP) and cyclic olefin copolymer (COC), polystyrene, poly- (4- Methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyester such as polyethylene terephthalate, polyethylene naphthalate, butadiene-styrene copolymer, polyamide (for example, nylon 6, nylon 6,6, Various resins such as nylon 6 · 10 and nylon 12) can be mentioned. Among them, polypropylene, cyclic polyolefin, polyester, and poly- (4-methylpentene-1) are preferable in that they are easy to mold. Resins are preferred.

  In addition, it is preferable that the constituent material of the outer cylinder 2 is substantially transparent in order to ensure internal visibility.

-Gasket-
A gasket 3 made of an elastic material is accommodated in the outer cylinder 2. A plurality of ring-shaped protrusions 31 and 32 are formed on the entire outer periphery of the gasket 3. By sliding the protrusions 31 and 32 in close contact with the inner peripheral surface 20 of the outer cylinder 2, the liquid tightness can be more reliably maintained and the slidability can be improved. Moreover, the front-end | tip part of the gasket 3 is comprised by the convex part 33 which makes a substantially conical convex shape.

  The constituent material of the gasket 3 is not particularly limited. For example, various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, polyester, polyamide, Examples thereof include elastic materials such as various thermoplastic elastomers such as olefins and styrenes, or mixtures thereof.

  The gasket 3 is connected to a pusher 4 for moving the gasket 3 in the longitudinal direction within the outer cylinder 2.

-Pusher-
The pusher 4 has a main body portion 40, and a flange-like finger contact portion 45 is formed at the base end of the main body portion 40. A finger is applied to the distal end surface or the proximal end surface of the finger contact portion 45, and the pusher 4 is pulled toward the proximal end or pushed toward the distal end.

  A head portion 43 that is inserted into the hollow portion of the gasket 3 and connected to the gasket 3 is formed on the distal end side of the main body portion 40. For example, a male screw that can be screwed with a female screw formed on the inner surface of the hollow portion of the gasket 3 is formed on the outer periphery of the head portion 43, and the gasket 3 and the pusher 4 are screwed together. And are connected.

  As a constituent material of the pusher 4, for example, polyvinyl chloride, polyethylene, polypropylene, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyethylene terephthalate, Various resins such as polyesters such as polyethylene naphthalate, butadiene-styrene copolymers, polyacetals, polyamides (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12) can be mentioned. In view of easiness, a resin such as polypropylene, polyester, or poly- (4-methylpentene-1) is preferable.

-Tip member-
A tip member 5 is provided in the outer cylinder 2. As will be described later, the distal end member 5 is a drug solution 100 remaining in the syringe 1 in a state where the pusher 4 is fully pushed against the outer cylinder 2 (a state in which further movement to the distal end side is substantially impossible). It is a member provided in order to reduce the amount of.

  More specifically, when the tip member 5 is omitted from the syringe 1, the gasket 3 cannot enter the lumen 23 of the outer cylinder 2 even if the pusher 4 is fully pushed. (Hereinafter, for convenience of explanation, the amount of the chemical solution 100 remaining in the syringe 1 with the pusher 4 fully pressed is also simply referred to as “residual amount”).

  The remaining amount varies depending on the size of the syringe 1 and the like, but is usually about 30 μL to 50 μL. For this reason, conventionally, it has been necessary to store a large amount of the chemical solution 100 in the syringe 1 in consideration of the remaining amount. Further, the chemical solution 100 remaining in the syringe 1 is discarded without being used. For this reason, the chemical solution 100 cannot be used efficiently, resulting in a problem of high costs. This problem is particularly noticeable when the chemical solution 100 is expensive or when the amount of the chemical solution 100 stored in the syringe 1 is small.

  The tip member 5 is a member for reducing the remaining amount of the chemical solution 100 in the syringe 1, and thus the chemical solution 100 can be efficiently used. Although it depends on the size of the syringe 1 and the like, the remaining amount of the chemical solution 100 is preferably about 1 to 30 μL, more preferably 1 to 15 μL, and more preferably 1 to 10 μL by using the tip member 5. Is more preferable. Thereby, the chemical liquid 100 can be efficiently used.

  As shown in FIG. 1, the distal end member 5 has a distal end portion 51 located in the lumen 23, a proximal end portion 52 located in the trunk portion 21, and a through hole 53. Such a tip member 5 is fixed to the outer cylinder 2 in a liquid-tight manner. Specifically, the tip member 5 is fixed to the outer cylinder 2 so that the chemical solution 100 does not enter between the outer peripheral surface (side surface) 5 a and the inner peripheral surface 20 of the outer cylinder 2. Thereby, the remaining amount can be reduced while suppressing the occurrence of sink marks due to the injection molding of the outer cylinder 2.

  The distal end portion 51 has a substantially truncated cone shape corresponding to the shape of the lumen 23. Further, a step 54 is formed at the boundary portion between the distal end portion 51 and the base end portion 52. Match. In this way, the tip member 5 has a truncated cone shape, and the step 54 is engaged with the step of the outer cylinder 2, whereby the movement of the tip member 5 toward the tip side with respect to the syringe 1 is restricted. It is possible to effectively prevent the tip member 5 from being detached from the outer cylinder 2 due to the pressure generated by moving the tip toward the tip side.

  Note that the distal end member 5 of the present embodiment can be fixed to the outer cylinder 2 by press-fitting from the proximal end side opening of the outer cylinder 2.

  The through hole 53 is formed linearly along the axis of the tip member 5. That is, the through hole 53 is formed so as to penetrate the bottom (center) of the recess 521 and the center of the tip surface of the tip 51. With such a through hole 53, the inside and outside of the outer cylinder 2 communicate with each other, and the chemical solution 100 can be guided out of the syringe 1 through the through hole 53. That is, the through hole 53 constitutes a flow path for the chemical solution 100.

  In the state where the pusher 4 is fully pushed against the outer cylinder 2, the chemical solution 100 remains in the through hole 53. Therefore, by reducing the volume of the through-hole 53, the remaining amount of the chemical solution 100 can be reduced (as described above, about 1 μL to 30 μL).

  Although it does not specifically limit as a constituent material of the front-end | tip member 5, The material quoted as a constituent material of the outer cylinder 2 can be used. In particular, the tip member 5 is preferably made of the same material as the constituent material of the outer cylinder 2. Thereby, manufacture of the syringe 1 can be facilitated.

  It is also preferable to make the rigidity of the tip member 5 lower than the rigidity of the outer cylinder 2. Thereby, it can prevent effectively that the outer cylinder 2 deform | transforms excessively by the press fit of the front-end | tip member 5, or is damaged, and the safety | security of the syringe 1 improves.

  In this case, if the rigidity of the edge of the tip member 5 is lower than the rigidity of the outer cylinder 2, the effect can be exerted. Therefore, the rigidity of the center part of the tip member 5 is, for example, that of the outer cylinder 2. May be higher. Specifically, for example, the tip member 5 is configured by a cylindrical first member whose inside forms the through-hole 53 and a second member provided around the first member, and the first member The rigidity may be higher than the rigidity of the second member. According to such a configuration, even if the second member is deformed by press-fitting into the outer cylinder 2, since the first member is not deformed, the deformation of the through hole 53 can be effectively suppressed. 1 reliability can be maintained.

  The tip member 5 can be manufactured by injection molding. When the tip member 5 is manufactured by injection molding, even if sink marks are generated, the tip member 5 is manufactured so that the sink marks are generated at a position where they do not come into contact with the chemical solution 100. Specifically, for example, as shown in FIG. 3A, a first mold 300 and a second mold 400 are prepared, and a resin material is supplied from a gate 410 formed in the second mold 400. A method is mentioned.

  According to such a method, as shown in FIG. 3B, even if a sink occurs in the manufactured tip member 5, the sink is a boundary between the first mold 300 and the second mold 400. Or at the boundary with the gate. These portions are all side surfaces of the tip member 5 and are portions that do not come into contact with the drug solution 100 in the syringe 1 as is apparent from FIG. 1. Therefore, even if sink marks are generated in the tip member 5, the sink marks do not come into contact with the chemical solution 100 in a state where the tip member 5 is incorporated in the outer cylinder 2. Thereby, it is possible to prevent sink marks from separating from the tip member 5 and floating on the chemical solution 100, and to ensure the safety of the chemical solution 100.

  According to the syringe 1 as described above, the remaining of the chemical solution can be suppressed while ensuring reliability and safety. Specifically, by providing the tip member 5 inside the reduced diameter portion 22, the volume of the lumen 23 into which the gasket 3 can not enter is reduced, so that the inside of the syringe 1 in a state where the pusher 4 is fully pushed. The remaining amount of the chemical solution 100 can be further reduced. In particular, according to such a configuration, since the thickness of the reduced diameter portion 22 can be reduced, the occurrence of sink marks or the like in the reduced diameter portion 22 can be effectively prevented, and the safety of the syringe 1 is ensured. can do.

  Moreover, according to the syringe 1, since it is not necessary to let the gasket 3 penetrate | invade in the reduced diameter part 22, the exact | strictness more than necessary is not required for the shape and position alignment of the gasket 3, and manufacture of the syringe 1 becomes easy. . Furthermore, unlike the prior art, the problem that the remaining amount of the chemical solution 100 increases without the gasket 3 entering the lumen 23 of the reduced diameter portion 22 cannot occur. That is, the syringe 1 is excellent in reliability and safety.

Second Embodiment
Next, a second embodiment of the syringe of the present invention will be described.

  FIG. 4 is a longitudinal sectional view showing a second embodiment of the syringe of the present invention. In the following, for convenience of explanation, the upper side in FIG. 4 is referred to as “base end” and the lower side is referred to as “tip”.

  Hereinafter, although the syringe of this embodiment is demonstrated, it demonstrates centering around difference with the syringe of the said 1st Embodiment, and abbreviate | omits the description about the same matter.

  The syringe of the present embodiment is the same as the syringe of the first embodiment except that the shape of the outer cylinder 2 and the configuration of the tip member are different.

  As shown in FIG. 4, in the syringe 1 </ b> A, the lumen 23 </ b> A of the reduced diameter portion 22 </ b> A included in the outer cylinder 2 </ b> A has a substantially cylindrical shape. That is, the inner cavity 23 </ b> A has a circular cross-sectional shape, and its cross-sectional area is substantially constant along the axial direction of the outer cylinder 2. A recess 221A is formed on the inner surface of the reduced diameter portion 22A. The concave portion 221A is a portion with which a convex portion 55A (described later) of the tip member 5A is engaged.

  As shown in FIG. 4, the tip member 5A has a cylindrical shape as a whole. 5 A of such front-end | tip members are provided in the through-hole 53A formed along the axis, the enlarged diameter part (positioning part) 54A provided in the front-end | tip part, and diameter-expanded with respect to the base end side, and outer cylinder 2A. It has the convex part (engagement part) 55A engaged with the formed recessed part 221A.

  Such a tip member 5A is fixed to the outer cylinder 2A by being press-fitted from the tip side opening (opening of the reduced diameter portion 22A) of the outer cylinder 2A. Thus, damage to the inner peripheral surface 20 of the body portion 21 of the outer cylinder 2A can be prevented by press-fitting the distal end member 5A from the opening on the front end side of the outer cylinder 2A. When the distal end member 5A is press-fitted into the outer cylinder 2, the enlarged diameter portion 54A comes into contact with the distal end surface of the reduced diameter portion 22A, whereby the distal end member 5A is positioned with respect to the outer cylinder 2. Further, with the enlarged diameter portion 54A in contact with the distal end surface of the reduced diameter portion 22A, the distal end member 5A is more firmly fixed to the outer cylinder 2A by engaging the convex portion 55A with the concave portion 221A. The

  By configuring the tip member 5A in such a configuration, the tip member 5A can be accurately positioned with respect to the outer cylinder 2A and can be more firmly fixed to the outer cylinder 2A. Thereby, the reliability of the syringe 1 improves.

  Further, a concave portion 56A having a substantially conical concave shape is formed at the proximal end portion of the distal end member 5A. A side surface 561A of the recess 56A is configured by a surface continuous with the inner surface 211a of the bottom 211 of the outer cylinder 2A. Thereby, the convex part 33, the bottom part 211, and the concave part 56A of the gasket 3 can be brought into close contact with the pusher 4 fully pressed, and the remaining amount of the chemical solution 100 can be further reduced.

<Third Embodiment>
Next, a third embodiment of the syringe of the present invention will be described.

  FIG. 5 is a longitudinal sectional view showing a third embodiment of the syringe of the present invention. In the following, for convenience of explanation, the upper side in FIG. 5 is referred to as “base end” and the lower side is referred to as “tip”.

  Hereinafter, although the syringe of this embodiment is demonstrated, it demonstrates centering around difference with the syringe of the said 1st Embodiment, and abbreviate | omits the description about the same matter.

  The syringe of this embodiment is the same as the syringe of the first embodiment except that the shape of the outer cylinder is different.

  As shown in FIG. 5, in the syringe 1B, the outer cylinder 2B includes a cylindrical barrel portion 21B and a reduced diameter portion 22B that is provided on the distal end side of the barrel portion 21B and whose inner diameter and outer diameter gradually decrease toward the distal end side. And have. That is, it can be said that the outer cylinder 2B has a configuration in which the bottom portion 211 is omitted from the outer cylinder 2 of the first embodiment described above.

Since the outer cylinder 2 has such a configuration, the shape of the outer cylinder 2 becomes simpler, and thus the outer cylinder 2 can be reduced in size. Therefore, the syringe 1B of this embodiment is particularly effective when the amount of the chemical solution 100 stored in the outer cylinder 2 is small (for example, about 50 to 500 μL).
A tip member 5B is provided in the outer cylinder 2 as described above.

  The distal end member 5B has a distal end portion 51B located in the reduced diameter portion 22B, a proximal end portion 52B located in the body portion 21B, and a through hole 53B. Such a tip member 5B is liquid-tightly fixed with respect to the outer cylinder 2B, and the chemical solution 100 is prevented from entering between the outer peripheral surface 5a and the inner peripheral surface 20 of the outer cylinder 2.

  Here, since the distal end member 5B has the base end portion 52B, in the syringe 1B, the step formed at the boundary between the body portion 21B and the reduced diameter portion 22B is covered by the distal end member 5B. Such a step is a portion that is liable to cause liquid to enter. Therefore, the chemical solution 100 is more effectively prevented from entering between the outer peripheral surface 5a and the inner peripheral surface 20 by covering the step with the tip member 5B.

  Further, since the distal end member 5B has the base end portion 52B, the distal end member 5 and the gasket 3 can be more reliably brought into contact when the pusher 4 is moved to the distal end side. Therefore, the remaining amount of the chemical solution 100 in the syringe 1 can be further reduced.

  As mentioned above, although the syringe of this invention was demonstrated about embodiment of illustration, this invention is not limited to this, Each part which comprises a syringe substitutes the thing of the arbitrary structures which can exhibit the same function. can do. Moreover, arbitrary components may be added.

  In addition, the syringe of the present invention may be a combination of any two or more configurations (features) of the above embodiments.

  In the above-described embodiment, a through hole is formed in the tip member, and this through hole constitutes a flow path for the chemical liquid. However, the flow path for the chemical liquid is not limited to the through hole. For example, the tip member is formed on the side surface and has a groove that opens to the base end surface and the tip surface of the tip member, and a channel formed by this groove and the inner wall of the reduced diameter portion is used as a channel for the chemical solution. Also good.

  Moreover, in embodiment mentioned above, it was the structure by which the chemical | medical solution (liquid) was previously accommodated in the syringe, For example, the chemical | medical agent as solid preparations, such as a powder formulation, may be accommodated in the syringe. In this case, a liquid obtained by injecting a liquid such as a solution into a syringe at the time of use and dissolving the drug in the liquid can be used as a “medical solution”.

DESCRIPTION OF SYMBOLS 1 Syringe 1A Syringe 1B Syringe 11 Space 2 Outer cylinder 2A Outer cylinder 2B Outer cylinder 20 Inner peripheral surface 21 Body part 21B Body part 211 Bottom part 211a Inner surface 22 Reduced diameter part 22A Reduced diameter part 22B Reduced diameter part 221A Recessed part 23 Lumen 23A Inside Cavity 27 Flange 3 Gasket 31 Protruding portion 32 Protruding portion 33 Protruding portion 33a Side surface 4 Pusher 40 Main body portion 43 Head portion 45 Finger rest portion 5 Tip member 5A Tip member 5B Tip member 5a Outer peripheral surface (side surface)
51 Tip 51B Tip 52 Base End 52B Base End 521 Concave 521a Side 53 Through Hole 53A Through Hole 53B Through Hole 54 Step 54A Expanded Part 55A Convex 56A Concave 561A Side 100 Chemical Solution 300 First Mold 400 Second Mold 410 Gate

Claims (7)

An outer cylinder that has a bottom portion, a mouth portion that communicates with the bottom portion, and has a mouth portion through which liquid can enter and exit on the tip side, and is formed with a substantially uniform overall thickness;
A gasket that can slide in the outer cylinder;
A syringe connected to the gasket and provided with a pusher for moving the gasket in the longitudinal direction of the outer cylinder;
A tip member disposed on the inside of the outer cylinder and having a flow path for the liquid communicating between the inside and outside of the outer cylinder;
The distal end member has a distal end portion located inside the mouth portion, and a proximal end portion located inside the trunk portion,
The base end portion covers the bottom portion of the barrel portion and is in contact with an inner peripheral surface of the barrel portion .   The syringe according to claim 1, wherein a volume of the flow path is 1 μL to 30 μL.   The syringe according to claim 1 or 2, wherein the tip member has a through-hole penetrating a base end surface and a tip end surface of the tip member, and an inner side of the through-hole forms the flow path.   The said front-end | tip member is press-fit in the said outer cylinder from the opening of the base end side of the said outer cylinder, The displacement to the front end side with respect to the said outer cylinder is controlled. Syringe.   The syringe according to any one of claims 1 to 3, wherein the distal end member is press-fitted into the outer cylinder from an opening on the distal end side of the outer cylinder. A concave portion having a substantially conical concave shape is formed at the proximal end portion of the distal end member,
The syringe according to any one of claims 1 to 5, wherein the through hole is open to a bottom portion of the recess. The tip member is formed by injection molding,
The syringe according to any one of claims 1 to 6, wherein a sink that may occur in the tip member by the injection molding is located at a position where the sink does not come into contact with the liquid.

Images