JP5770350B1 - Intraocular lens - Google Patents

Intraocular lens Download PDF

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JP5770350B1
JP5770350B1 JP2014196214A JP2014196214A JP5770350B1 JP 5770350 B1 JP5770350 B1 JP 5770350B1 JP 2014196214 A JP2014196214 A JP 2014196214A JP 2014196214 A JP2014196214 A JP 2014196214A JP 5770350 B1 JP5770350 B1 JP 5770350B1
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lens
capsule
equator
lens support
intraocular
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淳介 飽浦
淳介 飽浦
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Frontier Vision
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Abstract

【課題】水晶体嚢の前嚢側赤道部及び中央赤道部における水晶体上皮細胞の増殖を抑制し、水晶体上皮細胞の増殖に起因する後発白内障の発生および術後細菌性眼内炎の発生を抑制することができる眼内レンズを提供する。【解決手段】眼内レンズ1は、レンズからなる光学部10と、光学部10の周縁部に設けられた複数のレンズ支持部20とを備え、レンズ支持部20は、光学部10の周縁部から光学部10の周方向に沿って延びる態様で設けられる。中間部22から先端部23にかけて水晶体嚢の赤道部Seに係止され、水晶体嚢の赤道部Seに係止される部分の前側、外側および後側において、光学部10の径方向に延びる態様の突出部210がレンズ支持部20の長さ方向に沿って複数設けられ、互いに隣接する突出部210の間に前房水Fが流入して赤道部Seに接したあと、後嚢Sb側に流出するものとなされている。【選択図】図1An object of the present invention is to suppress the proliferation of lens epithelial cells in the equator and central equator of the anterior capsule of the lens capsule, and to suppress the occurrence of secondary cataract and postoperative bacterial endophthalmitis due to the proliferation of lens epithelial cells An intraocular lens is provided. An intraocular lens (1) includes an optical unit (10) composed of a lens and a plurality of lens support units (20) provided at a peripheral part of the optical unit (10). The lens support unit (20) is a peripheral part of the optical unit (10). To the optical unit 10 in a manner extending along the circumferential direction. It is locked to the equator part Se of the lens capsule from the intermediate part 22 to the tip part 23, and extends in the radial direction of the optical part 10 on the front side, outside and rear side of the part locked to the equator part Se of the lens capsule. A plurality of protrusions 210 are provided along the length direction of the lens support part 20, and the anterior aqueous humor F flows between the protrusions 210 adjacent to each other and comes into contact with the equator part Se, and then flows out toward the posterior capsule Sb. It is supposed to be. [Selection] Figure 1

Description

本発明は、白内障手術等において水晶体嚢の前嚢が切開され、内容物が除去された水晶体嚢内に挿入される眼内レンズに関する。   The present invention relates to an intraocular lens that is inserted into a lens capsule from which an anterior capsule of the lens capsule has been incised and contents are removed in a cataract surgery or the like.

眼の水晶体に生じる病気には、主に加齢が原因となって混濁する白内障という病気があり、多くの患者がこの白内障を治療するための白内障手術を受けている。   A disease that occurs in the lens of the eye is a cataract that becomes cloudy mainly due to aging, and many patients undergo cataract surgery to treat this cataract.

現在、白内障手術は超音波水晶体乳化吸引術が主流であり、この超音波水晶体乳化吸引術は、2.4〜3.0mmの小切開から、水晶体の前嚢に連続円形切開を作り、水晶体の濁った中身を超音波の振動と吸引を用いて除去し、透明な水晶体嚢だけにして、その水晶体嚢内に眼内レンズ(IOL)を入れる術式である。   At present, ultrasonic lens emulsification is the mainstream for cataract surgery, and this ultrasonic lens emulsification is performed by making a continuous circular incision in the anterior capsule of the lens from a small incision of 2.4 to 3.0 mm. The turbid contents are removed using ultrasonic vibration and suction, and only a transparent capsular bag is formed, and an intraocular lens (IOL) is inserted into the capsular bag.

ところが、手術後に水晶体嚢内の前嚢と赤道部に存在する水晶体上皮細胞が増殖して水晶体嚢が濁る状態が発生することがあり、この状態が後発白内障と呼ばれる。特に、後嚢中央部に水晶体上皮細胞が入り込んで後嚢が濁ると視力障害が発生する。この水晶体上皮細胞は、特に前嚢側赤道部と中央赤道部で分裂・増殖能が大きいことが知られている。   However, there is a case where the lens epithelial cells existing in the anterior capsule and the equator in the lens capsule proliferate after the operation and the lens capsule becomes cloudy, and this condition is called secondary cataract. In particular, visual impairment occurs when lens epithelial cells enter the central part of the posterior capsule and the posterior capsule becomes cloudy. It is known that this lens epithelial cell has a high ability to divide and proliferate, particularly in the anterior capsular equator and the central equator.

この後発白内障に対して、眼内レンズの光学部や支持部の辺縁部の後嚢側に角度をつけた形状(シャープエッジ形状)を採用して、その角の所で水晶体嚢に急で連続的な屈曲部を作り、水晶体上皮細胞の後嚢中央部への侵入を防止することで後発白内障を抑制しようとする事が一般的に行われている(例えば、特許文献1参照)。   For this subsequent cataract, we adopted a shape (sharp edge shape) with an angle on the posterior capsule side of the optical part of the intraocular lens and the edge of the support part. In general, it has been attempted to suppress the subsequent cataract by creating a continuous bent portion and preventing the lens epithelial cells from entering the central portion of the posterior capsule (see, for example, Patent Document 1).

また、前嚢と後嚢が赤道部で癒着することで水晶体上皮細胞の増殖がはじまって後発白内障が発生すると言われており、水晶体嚢の赤道部近傍に厚みのある輪状のもの(赤道部リングと言われる)を設置して前嚢と後嚢の接着を防いで後発白内障を防止しようとするものもある(例えば、特許文献2参照)。また、この赤道部リングと光学部が一体となったディスク型眼内レンズも開発されている。さらに後発白内障の抑制効果を高めるため、シャープエッジをもった赤道部リングもある。   In addition, it is said that the epithelial cells proliferate due to the adhesion between the anterior capsule and the posterior capsule at the equator, and the subsequent cataract occurs, and there is a thick ring (equatorial ring near the equator of the lens capsule). Some have tried to prevent the subsequent cataract by preventing the adhesion between the anterior capsule and the posterior capsule (see, for example, Patent Document 2). In addition, a disc-type intraocular lens in which the equator ring and the optical part are integrated has been developed. In addition, there is an equatorial ring with sharp edges to enhance the effect of suppressing secondary cataracts.

ところで、最近、前房水には後発白内障を抑制する効果があることが知られるようになってきた。後発白内障は、水晶体上皮細胞からサイトカイン等のケミカルメディエイター(化学伝達物質)が分泌されて水晶体上皮細胞の増殖のスイッチが入ることで始まるとされており、前房水が水晶体上皮細胞に流入することでこのサイトカインが洗い流されて、水晶体上皮細胞の増殖のスイッチが入らず、後発白内障が抑制される機序が考えられている。   Recently, it has been known that anterior aqueous humor has an effect of suppressing secondary cataract. Late cataract is said to start by the secretion of chemical mediators (chemical mediators) such as cytokines from the lens epithelial cells and switching on the growth of lens epithelial cells, and the anterior chamber fluid flows into the lens epithelial cells Thus, a mechanism is considered in which this cytokine is washed away, the lens epithelial cell proliferation is not switched on, and the subsequent cataract is suppressed.

一方、眼科医や患者が最も恐れる術後合併症の1つは術後細菌性眼内炎であり、術中に眼内にもち込まれた細菌が術後眼内で増殖して炎症を起こし、早期の処置を誤れば網膜に炎症が波及して失明することもある。この術後眼内炎を起こす詳細な原因は分かっていないが、図11Bに示すように、眼内レンズ100が挿入された直後から水晶体嚢の赤道部Seはふくらみを失い偏平になり、前嚢Sfと後嚢Sbは眼内レンズ100の表面に接着し、眼内レンズ100と後嚢Sbの間にできる前房水Fの入り込まない一種の閉鎖空間Vが、細菌増殖の足場となることが考えられている。   On the other hand, one of the postoperative complications most feared by ophthalmologists and patients is postoperative bacterial endophthalmitis. Bacteria in the eye during the operation proliferate in the eye and cause inflammation. If early treatment is mistaken, inflammation may spread to the retina and cause blindness. Although the detailed cause of this postoperative endophthalmitis is not known, as shown in FIG. 11B, immediately after the intraocular lens 100 is inserted, the equator portion Se of the capsular bag loses its bulge and becomes flattened. Sf and the posterior capsule Sb adhere to the surface of the intraocular lens 100, and a kind of closed space V where the anterior aqueous humor F does not enter between the intraocular lens 100 and the posterior capsule Sb may be a scaffold for bacterial growth. It is considered.

すなわち、眼内レンズ100の裏の洗浄が不十分で、血液や眼瞼からの分泌物や術中に使用される粘弾性物質がその閉鎖空間Vに残っている場合、前房水Fがその閉鎖空間Vに入り込めず、前房水F中に含まれるマクロファージなどの免疫系が働かないため、前述した血液や眼瞼からの分泌物などの中の細菌が閉鎖空間Vの中で増殖するのである。このため、眼内レンズと水晶体嚢Sが癒着しないようにして、前房水Fが眼内レンズの裏に入り込めるような空間(ルート)を確保するようにすれば、術後細菌性眼内炎の発生の抑制に効果があると考えられる。   That is, when the back of the intraocular lens 100 is not sufficiently cleaned, and blood and eyelid secretions and viscoelastic substances used during the operation remain in the closed space V, the anterior aqueous humor F is in the closed space. Since the immune system, such as macrophages contained in the anterior aqueous humor F, does not enter the V, the bacteria in the aforementioned blood and secretions from the eyelids grow in the closed space V. Therefore, if the intraocular lens and the capsular bag S are not adhered to each other and a space (root) for allowing the anterior aqueous humor F to enter the back of the intraocular lens is secured, postoperative bacterial endophthalmitis This is thought to be effective in suppressing the occurrence of

特開2007−89810号公報JP 2007-89810 A 実開平5−58118号公報Japanese Utility Model Publication No. 5-58118

本発明は、上述の技術的背景に鑑みてなされたものであり、第1に、水晶体嚢の赤道部における水晶体上皮細胞の増殖を抑制し、水晶体上皮細胞の増殖に起因する後発白内障の発生を抑制することができ、第2に、術後細菌性眼内炎の発生を抑制することができる眼内レンズを提供することを目的とする。   The present invention has been made in view of the above-described technical background. First, it suppresses the proliferation of lens epithelial cells in the equator portion of the lens capsule, and causes the occurrence of subsequent cataract caused by the proliferation of lens epithelial cells. It is an object of the present invention to provide an intraocular lens that can be suppressed, and secondly, can suppress the occurrence of postoperative bacterial endophthalmitis.

本発明は、上記目的を達成するために、白内障手術等において内容物が除去された水晶体嚢内に挿入される眼内レンズであって、レンズからなる光学部と、該光学部の周縁部に設けられた複数のレンズ支持部とを備え、前記レンズ支持部は、光学部の周縁部から光学部の周方向に沿って延びる態様で設けられ、少なくとも中間部が水晶体嚢の赤道部に係止され、水晶体嚢の赤道部に係止される部分の少なくとも前側、外側および後側において、光学部の径方向に延びる態様の突出部がレンズ支持部の長さ方向に沿って複数設けられ、互いに隣接する突出部の間に前房水が流入することを特徴とする。   In order to achieve the above object, the present invention provides an intraocular lens to be inserted into a capsular bag from which contents have been removed in a cataract surgery or the like, and is provided on an optical part comprising the lens and a peripheral part of the optical part. A plurality of lens support portions, wherein the lens support portions are provided in a form extending from the peripheral portion of the optical portion along the circumferential direction of the optical portion, and at least an intermediate portion is locked to the equator portion of the lens capsule. A plurality of protrusions extending in the radial direction of the optical portion are provided along the length direction of the lens support portion at least on the front side, the outer side, and the rear side of the portion locked to the equator portion of the lens capsule and adjacent to each other An anterior aqueous humor flows between the protruding portions.

これによれば、前房水が互いに隣接する突出部の間の凹部に流入し、水晶体嚢の前嚢側赤道部、中央赤道部および後嚢側赤道部に接しながら順に凹部内を流れることにより、水晶体嚢の赤道部に残留する水晶体上皮細胞から分泌され、水晶体上皮細胞の増殖を促すサイトカイン等の化学伝達物質を洗い流すことができる。このため、水晶体嚢の赤道部における水晶体上皮細胞の増殖を抑制し、水晶体上皮細胞の増殖に起因する後発白内障の発生を抑制することが可能となる。   According to this, the anterior aqueous humor flows into the recesses between the adjacent protrusions, and flows in the recesses in order while in contact with the anterior capsule side equator part, the central equator part and the posterior capsule side equator part of the lens capsule. It is possible to wash away chemical mediators such as cytokines secreted from the lens epithelial cells remaining in the equator of the lens capsule and promoting the proliferation of the lens epithelial cells. For this reason, it is possible to suppress the growth of lens epithelial cells in the equator portion of the lens capsule and to suppress the occurrence of secondary cataract caused by the proliferation of lens epithelial cells.

また、前房水は、隣接する突出部の間の凹部内を流れたあと、後嚢側にすみやかに流出することができる。このため、前房水が、細菌増殖の足場となる眼内レンズの裏面と後嚢の間の空間に流入しやすくなり、術後細菌性眼内炎の発生を抑制することが可能となる。   Further, the anterior aqueous humor can flow out to the posterior capsule side immediately after flowing in the recesses between the adjacent projecting portions. For this reason, anterior aqueous humor becomes easy to flow into the space between the back surface of the intraocular lens which becomes a scaffold for bacterial growth and the posterior capsule, and it becomes possible to suppress the occurrence of postoperative bacterial endophthalmitis.

また、前記レンズ支持部は、前記突出部の前後径が光学部の前後径よりも大きく形成されているのが好ましい。これによれば、レンズ支持部の突出部が水晶体嚢の赤道部を前後に十分に開いて、前嚢と後嚢の癒着や眼内レンズと水晶体嚢の癒着を防止することができる。このため、前房水がレンズ支持部の隣接する突出部の間を通ってより広い範囲の水晶体嚢の赤道部に接することになり、より効果的に後発白内障を抑制することが可能となる。また、前房水が眼内レンズの裏面と後嚢の間の空間に流入しやすくなり、より効果的に術後細菌性眼内炎の発生を抑制することが可能となる。   Moreover, it is preferable that the said lens support part is formed so that the front-back diameter of the said protrusion part may be larger than the front-back diameter of an optical part. According to this, the protruding part of the lens support part can sufficiently open the equator part of the lens capsule forward and backward, thereby preventing adhesion between the anterior capsule and the posterior capsule and adhesion between the intraocular lens and the lens capsule. For this reason, the anterior aqueous humor passes between the adjacent protrusions of the lens support part and comes into contact with the equator part of the capsular bag in a wider range, and it becomes possible to more effectively suppress the secondary cataract. In addition, the anterior aqueous humor is likely to flow into the space between the back surface of the intraocular lens and the posterior capsule, and the postoperative bacterial endophthalmitis can be more effectively suppressed.

また、前記レンズ支持部は、基端部の前後径が光学部の前後径よりも大きく形成されているのが好ましい。これによれば、レンズ支持部の基端部が水晶体嚢の赤道部を前後に十分に開いて、前嚢と後嚢の癒着や眼内レンズと水晶体嚢の癒着を防止することができる。このため、前房水がレンズ支持部の隣接する突出部の間を通ってより広い範囲の水晶体嚢の赤道部に接することになり、より効果的に後発白内障を抑制することが可能となる。また、前房水が眼内レンズの裏面と後嚢の間の空間に流入しやすくなり、より効果的に術後細菌性眼内炎の発生を抑制することが可能となる。   Moreover, it is preferable that the said lens support part is formed so that the front-back diameter of a base end part may be larger than the front-back diameter of an optical part. According to this, the base end part of the lens support part can sufficiently open the equator part of the lens capsule forward and backward, thereby preventing adhesion between the anterior capsule and the posterior capsule and adhesion between the intraocular lens and the lens capsule. For this reason, the anterior aqueous humor passes between the adjacent protrusions of the lens support part and comes into contact with the equator part of the capsular bag in a wider range, and it becomes possible to more effectively suppress the secondary cataract. In addition, the anterior aqueous humor is likely to flow into the space between the back surface of the intraocular lens and the posterior capsule, and the postoperative bacterial endophthalmitis can be more effectively suppressed.

また、前記レンズ支持部は、各レンズ支持部を合わせて水晶体嚢の全周の75%以上に亘って赤道部に係止されているのが好ましい。特に、前記レンズ支持部は、隣接するレンズ支持部同士が周方向に互いに連結されたリング状に形成されているのが好ましい。これによれば、眼内レンズを確実に水晶体嚢に係止させることができると共に、水晶体嚢の赤道部における前嚢と後嚢の間の癒着をより確実に防止することができ、前房水がレンズ支持部の隣接する突出部の間を通って広い範囲で水晶体嚢の赤道部に接することが可能となる。   Moreover, it is preferable that the said lens support part is latched by the equator part over 75% or more of the perimeter of a lens capsule, combining each lens support part. In particular, the lens support portion is preferably formed in a ring shape in which adjacent lens support portions are connected to each other in the circumferential direction. According to this, the intraocular lens can be reliably locked to the capsular bag, and adhesion between the anterior capsule and the posterior capsule in the equator of the capsular bag can be more reliably prevented. Can be in contact with the equator of the capsular sac over a wide range through the adjacent protrusions of the lens support.

また、前記レンズ支持部は、基端部の前側において、該レンズ支持部の長さ方向に延びる態様の凹部が設けられ、該凹部内に前房水が流入するが好ましい。これによれば、前房水が水晶体嚢の前嚢に接することにより、水晶体嚢の前嚢に残留する水晶体上皮細胞から分泌され、水晶体上皮細胞の増殖を促すサイトカイン等の化学伝達物質を洗い流すことができる。   Moreover, it is preferable that the lens support portion is provided with a concave portion extending in the length direction of the lens support portion on the front side of the base end portion, and the aqueous humor flows into the concave portion. According to this, the anterior aqueous humor comes into contact with the anterior capsule of the lens capsule, thereby washing away chemical transmitters such as cytokines that are secreted from the lens epithelial cells remaining in the anterior capsule of the lens capsule and promote the proliferation of the lens epithelial cells. Can do.

また、前記レンズ支持部は、基端部の前側、外側および後側において、レンズ支持部の周方向に延びる態様の凹部が設けられ、該凹部内に前房水が流入するのが好ましい。これによれば、前房水が基端部近傍の水晶体嚢の前嚢および赤道部に接することにより、基端部近傍の水晶体嚢の前嚢および赤道部に残留する水晶体上皮細胞から分泌され、水晶体上皮細胞の増殖を促すサイトカイン等の化学伝達物質を洗い流すことができる。   Further, it is preferable that the lens support portion is provided with a concave portion extending in the circumferential direction of the lens support portion on the front side, the outer side, and the rear side of the base end portion, and the anterior aqueous humor flows into the concave portion. According to this, the anterior aqueous humor is secreted from the lens epithelial cells remaining in the anterior capsule and equator of the lens capsule near the proximal end by contacting the anterior capsule and equator of the lens capsule near the proximal end, Chemical mediators such as cytokines that promote the proliferation of lens epithelial cells can be washed away.

また、前記レンズ支持部は、長さ方向に着脱可能に分割されてもよい。これによれば、術前の超音波生体顕微鏡(UBM)や光干渉断層計(OCT)による計測で予想した水晶体嚢の大きさに合わせて術前にレンズ支持部の長さを変えることができるため、より安定して眼内レンズを水晶体嚢内に係止させることができる。   Further, the lens support portion may be divided so as to be detachable in the length direction. According to this, the length of the lens support portion can be changed before the operation in accordance with the size of the lens capsule predicted by the measurement by the ultrasonic biomicroscope (UBM) or the optical coherence tomography (OCT) before the operation. Therefore, the intraocular lens can be locked in the lens capsule more stably.

また、前記レンズ支持部は、前記突出部の少なくとも前側および/または外側の周端部に凹凸が設けられているのが好ましい。これによれば、水晶体嚢の赤道部と突出部の周端部との間に空間が形成されるため、前房水が水晶体嚢の赤道部に接し易くなる。   In addition, it is preferable that the lens support portion is provided with irregularities at least at the front end and / or the outer peripheral end portion of the protrusion. According to this, since a space is formed between the equator portion of the lens capsule and the peripheral end portion of the protruding portion, the anterior aqueous humor can easily come into contact with the equator portion of the lens capsule.

また、前記レンズ支持部は、前記突出部の前後径が0.8mm以上で、前記突出部の突出高さが0.2mm以上に形成されているのが好ましい。特に、前記レンズ支持部は、前記突出部の前後径が1.0mm〜2.0mmで、前記突出部の突出高さが0.3mm〜0.8mmに形成されているのが好ましい。これによれば、前房水が隣接する突出部の間に確実に流入することができる。また、突出部が水晶体嚢の赤道部を前後に確実に開いて、水晶体嚢の前嚢と後嚢の癒着や水晶体嚢と眼内レンズの癒着を確実に防ぐことができる。   Moreover, it is preferable that the said lens support part is formed so that the front-back diameter of the said protrusion part is 0.8 mm or more, and the protrusion height of the said protrusion part is 0.2 mm or more. In particular, it is preferable that the lens support portion is formed so that the front-rear diameter of the protrusion is 1.0 mm to 2.0 mm and the protrusion height of the protrusion is 0.3 mm to 0.8 mm. According to this, the anterior aqueous humor can surely flow into between the adjacent protrusions. In addition, the protrusion can reliably open the equator of the lens capsule back and forth, thereby reliably preventing the adhesion between the anterior capsule and the posterior capsule of the lens capsule and the adhesion between the lens capsule and the intraocular lens.

また、前記レンズ支持部は、前記突出部の厚みが1.0mm以下で、隣接する前記突出部の間隔が0.2mm以上に形成されているのが好ましい。特に、前記突出部の厚みが0.1mm〜0.5mmで、隣接する前記突出部の間隔が0.3mm〜0.9mmに形成されているのが好ましい。これによれば、水晶体嚢の赤道部と突出部の接触面積が小さくなるため、前房水が水晶体嚢の赤道部に広い範囲で接することができる。また、眼内レンズをインジェクタで眼内に挿入する場合に、インジェクタ内で小さく折り畳み易くなり、折り畳んだ眼内レンズを挿入する切開創をより小さくすることができる。   Moreover, it is preferable that the said lens support part is formed so that the thickness of the said protrusion part is 1.0 mm or less, and the space | interval of the said adjacent protrusion part is 0.2 mm or more. In particular, it is preferable that the protrusions have a thickness of 0.1 mm to 0.5 mm and an interval between adjacent protrusions is 0.3 mm to 0.9 mm. According to this, since the contact area between the equator portion and the protruding portion of the lens capsule is reduced, the anterior aqueous humor can contact the equator portion of the lens capsule in a wide range. In addition, when an intraocular lens is inserted into the eye with an injector, it can be easily folded small in the injector, and the incision for inserting the folded intraocular lens can be made smaller.

本発明によれば、前房水が互いに隣接する突出部の間に流入し、水晶体嚢の前嚢側赤道部、中央赤道部および後嚢側赤道部を順に接することにより、水晶体嚢の赤道部に残留する水晶体上皮細胞から分泌され、水晶体上皮細胞の増殖を促すサイトカイン等の化学伝達物質を洗い流すことができる。このため、水晶体嚢の赤道部における水晶体上皮細胞の増殖を抑制し、水晶体上皮細胞の増殖に起因する後発白内障の発生を抑制することが可能となる。   According to the present invention, the anterior aqueous humor flows between adjacent protrusions and contacts the anterior capsular equator, the central equator and the posterior capsule equator of the capsular bag in order, thereby It is possible to wash away chemical mediators such as cytokines secreted from lens epithelial cells remaining in the cells and promoting proliferation of lens epithelial cells. For this reason, it is possible to suppress the growth of lens epithelial cells in the equator portion of the lens capsule and to suppress the occurrence of secondary cataract caused by the proliferation of lens epithelial cells.

また、前房水は、隣接する突出部の間に流入したあと後嚢側にすみやかに流出することができる。このため、前房水が細菌増殖の足場となる眼内レンズの裏面と後嚢の間の空間に流入しやすくなり、術後細菌性眼内炎の発生を抑制することが可能となる。   In addition, the anterior aqueous humor can quickly flow out to the posterior capsule side after flowing between the adjacent protrusions. For this reason, it becomes easy for the aqueous humor to flow into the space between the back surface of the intraocular lens that serves as a scaffold for bacterial growth and the posterior capsule, and it is possible to suppress the occurrence of postoperative bacterial endophthalmitis.

第1の実施形態に係る眼内レンズの平面図である。It is a top view of the intraocular lens which concerns on 1st Embodiment. 図1の眼内レンズの側面図である。It is a side view of the intraocular lens of FIG. 図1の眼内レンズの縦断面図である。It is a longitudinal cross-sectional view of the intraocular lens of FIG. 図1のレンズ支持部の拡大平面図である。It is an enlarged plan view of the lens support part of FIG. 図4のレンズ支持部のV−V線断面矢視図である。It is a VV sectional view taken on the line of the lens support part of FIG. 図1のレンズ支持部の拡大縦断面図である。FIG. 2 is an enlarged longitudinal sectional view of a lens support portion in FIG. 1. 図1の眼内レンズのレンズ支持部の変形例を示す平面図である。It is a top view which shows the modification of the lens support part of the intraocular lens of FIG. 図1の眼内レンズの突出部の変形例を示す縦断面図である。It is a longitudinal cross-sectional view which shows the modification of the protrusion part of the intraocular lens of FIG. 図1の眼内レンズのレンズ支持部の変形例を示す拡大平面図である 。It is an enlarged plan view which shows the modification of the lens support part of the intraocular lens of FIG. 第2の実施形態に係る眼内レンズの平面図である。It is a top view of the intraocular lens which concerns on 2nd Embodiment. 水晶体嚢における前房水の流れを示す説明図である。It is explanatory drawing which shows the flow of the anterior aqueous humor in a lens capsule.

<第1の実施形態>
次に、本発明に係る眼内レンズの第1の実施形態について図1〜図6を参照しつつ説明する。
<First Embodiment>
Next, a first embodiment of an intraocular lens according to the present invention will be described with reference to FIGS.

本実施形態に係る眼内レンズ1は、白内障手術等において内容物が除去された水晶体嚢S内に前嚢Sfの切開部Opから挿入されるものである。この眼内レンズ1は、図1に示すように、レンズからなる光学部10と、光学部10の周縁部に設けられた3個のレンズ支持部20とを備える。   The intraocular lens 1 according to this embodiment is inserted from the incision part Op of the anterior capsule Sf into the lens capsule S from which the contents have been removed in a cataract surgery or the like. As shown in FIG. 1, the intraocular lens 1 includes an optical unit 10 made of a lens, and three lens support units 20 provided on the peripheral edge of the optical unit 10.

前記光学部10は、図1に示すように、平面視円形の凸レンズ状に形成され、シリコン、アクリル、ハイドロジェル、PMMA、HEMA、あるいはヒドロ・ポリマー等の合成樹脂素材からなる。光学部10の直径は、5.0mm〜6.5mm、前後径は、0.4mm〜0.7mmに形成されている。   As shown in FIG. 1, the optical unit 10 is formed in a convex lens shape having a circular shape in plan view, and is made of a synthetic resin material such as silicon, acrylic, hydrogel, PMMA, HEMA, or hydropolymer. The optical part 10 has a diameter of 5.0 mm to 6.5 mm, and a front and rear diameter of 0.4 mm to 0.7 mm.

前記レンズ支持部20は、図1に示すように、光学部10の周縁部において周方向に等間隔に設けられ、光学部10の中心に対して点対称の配置構成となっている。これら各レンズ支持部20は、光学部10とほぼ同一平面上に設けられ、光学部10の周縁部に接続された基端部21から中間部22、先端部23にかけて、光学部10の周囲において周方向に沿って延びる態様に形成されている。また、このレンズ支持部20は、シリコン、アクリル、PMMA、ポリイミド、ポリフッ化ビニリデン、HEMA、あるいはポリプロピレン等の合成樹脂製からなる。   As shown in FIG. 1, the lens support portions 20 are provided at equal intervals in the circumferential direction at the peripheral portion of the optical portion 10, and have a point-symmetric arrangement configuration with respect to the center of the optical portion 10. Each of these lens support portions 20 is provided on substantially the same plane as the optical portion 10, and extends from the proximal end portion 21 connected to the peripheral portion of the optical portion 10 to the intermediate portion 22 and the distal end portion 23 around the optical portion 10. It is formed in a mode extending along the circumferential direction. The lens support 20 is made of a synthetic resin such as silicon, acrylic, PMMA, polyimide, polyvinylidene fluoride, HEMA, or polypropylene.

また、前記レンズ支持部20は、眼内レンズ1が水晶体嚢S内に挿入された際、中間部22および先端部23が水晶体嚢Sの赤道部Seに係止される。これにより光学部10は、水晶体嚢Sの赤道部Seに3個のレンズ支持部20を介して支持され、水晶体嚢S内で前嚢Sfおよび後嚢Sbに略平行な状態となる。特に本実施形態では、レンズ支持部20は、各レンズ支持部20を合わせて水晶体嚢Sの全周の75%以上に亘って赤道部Seに係止されているため、光学部10は安定良く支持され得るとともに、水晶体嚢Sの赤道部Seにおける前嚢Sfと後嚢Sbの間の癒着をより確実に防ぐことができ、後述するように、前房水Fがレンズ支持部20の隣接する突出部210の間を通って広い範囲で水晶体嚢Sの赤道部Seに接することが可能となる。   The lens support portion 20 is engaged with the equator portion Se of the lens capsule S at the intermediate portion 22 and the distal end portion 23 when the intraocular lens 1 is inserted into the lens capsule S. As a result, the optical unit 10 is supported by the equator Se of the lens capsule S via the three lens support portions 20, and is in a state substantially parallel to the anterior capsule Sf and the posterior capsule Sb in the lens capsule S. In particular, in the present embodiment, the lens support portion 20 is locked to the equator Se over 75% or more of the entire circumference of the lens capsule S together with the lens support portions 20, so that the optical portion 10 is stable. As well as being supported, adhesion between the anterior capsule Sf and the posterior capsule Sb in the equator Se of the lens capsule S can be more reliably prevented, and the anterior aqueous humor F is adjacent to the lens support 20 as will be described later. It becomes possible to contact the equator portion Se of the capsular bag S in a wide range through the protruding portions 210.

なお、レンズ支持部20は、基端部21が光学部10の周縁部に向かうに従って幅広に形成されている。このためレンズ支持部20の中間部22および先端部23が水晶体嚢Sの赤道部Seから比較的大きな力を受けても、基端部21が不必要に屈曲することを防止できる。   In addition, the lens support part 20 is formed so that the base end part 21 goes to the peripheral part of the optical part 10, and becomes wide. For this reason, even if the intermediate portion 22 and the distal end portion 23 of the lens support portion 20 receive a relatively large force from the equator portion Se of the lens capsule S, the proximal end portion 21 can be prevented from being bent unnecessarily.

また、各レンズ支持部20は、図1〜図5に示すように、レンズ支持部20の長さ方向に延びる支持部本体200と、該支持部本体200に設けられた6個の突出部210とを備える。   As shown in FIGS. 1 to 5, each lens support portion 20 includes a support portion main body 200 extending in the length direction of the lens support portion 20, and six projecting portions 210 provided on the support portion main body 200. With.

前記支持部本体200は、光学部10の周囲において光学部10の周方向に沿って緩やかに湾曲するように形成されている。また、この支持部本体200は、図6に示すように、断面が光学部10の径方向に長い長円状に形成されている。   The support body 200 is formed so as to be gently curved along the circumferential direction of the optical unit 10 around the optical unit 10. Further, as shown in FIG. 6, the support body 200 is formed in an oval shape having a cross section that is long in the radial direction of the optical unit 10.

前記突出部210は、支持部本体200の長さ方向に沿って所定の間隔で並んで設けられている。具体的には、この突出部210は、支持部本体200の周面から直角に突出し、断面が光学部10の厚み方向(前後方向)に長い環状に形成されている。   The protrusions 210 are provided at predetermined intervals along the length direction of the support body 200. Specifically, the protrusion 210 protrudes from the peripheral surface of the support body 200 at a right angle, and has a cross section that is long in the thickness direction (front-rear direction) of the optical unit 10.

また、前記突出部210は、図6に示すように、眼内レンズ1が水晶体嚢S内に挿入された際、前側(図6の上側)が水晶体嚢Sの前嚢側赤道部Se1に接触し、外側(図6の左側)が水晶体嚢Sの中央赤道部Se2に接触し、後側(図6の下側)が水晶体嚢Sの後嚢側赤道部Se3に接触する。
また、隣り合う突出部210同士の間には、前房水Fが流入するための凹部220が形成されている。この凹部220は、レンズ支持部20の周面に設けられた断面コ字状の溝であって、隣り合う突出部210の対向する側面を両側面221、222、支持部本体200の周面を底面223として、レンズ支持部20の周面を一周して延びる溝として形成される。よって、前房水Fは、凹部220内に流入したあと、前嚢側赤道部Se1、中央赤道部Se2および後嚢側赤道部Se3を接しながら凹部220内を順に流れたあと、後嚢Sb側に流出することができる。
Further, as shown in FIG. 6, when the intraocular lens 1 is inserted into the capsular bag S, the protruding portion 210 is in contact with the anterior capsular equator portion Se <b> 1 of the capsular bag S when the front side (upper side in FIG. The outer side (left side in FIG. 6) contacts the central equator part Se2 of the lens capsule S, and the rear side (lower side in FIG. 6) contacts the posterior capsule side equator part Se3 of the lens capsule S.
Moreover, between the adjacent protrusion parts 210, the recessed part 220 for the anterior aqueous humor F to flow in is formed. The concave portion 220 is a groove having a U-shaped cross section provided on the peripheral surface of the lens support portion 20. The opposite side surfaces of adjacent protrusions 210 are opposite side surfaces 221 and 222, and the peripheral surface of the support portion main body 200 is the same. The bottom surface 223 is formed as a groove extending around the peripheral surface of the lens support portion 20. Therefore, after the anterior aqueous humor F flows into the recess 220, the anterior aqueous sac F flows in the recess 220 in order while contacting the anterior capsule side equatorial part Se1, the central equator part Se2, and the posterior capsule side equator part Se3, Can be spilled into.

また、前記突出部210は、図3〜図5に示すように、前後径Lが光学部10の前後径よりも大きく形成されている。具体的には、突出部210の前後径Lが0.8mm以上、突出部210の突出高さが0.2mm以上に形成されている。特に好ましくは、突出部210の前後径Lが1.0mm〜2.0mmで、突出部210の突出高さが0.3mm〜0.8mmに形成されている。これによれば、突出部210が水晶体嚢Sの赤道部Seを前後に十分に開いて、水晶体嚢Sの前嚢Sfと後嚢Sbの癒着や水晶体嚢Sと眼内レンズ1の癒着を防ぐことができる。なお、本明細書において、突出部210の前後径とは、突出部210の前端部から後端部までの長さをいう。   Further, as shown in FIGS. 3 to 5, the protruding portion 210 is formed such that the front-rear diameter L is larger than the front-rear diameter of the optical unit 10. Specifically, the front-rear diameter L of the protrusion 210 is 0.8 mm or more, and the protrusion height of the protrusion 210 is 0.2 mm or more. Particularly preferably, the protrusion 210 has a front-rear diameter L of 1.0 mm to 2.0 mm and a protrusion height of the protrusion 210 of 0.3 mm to 0.8 mm. According to this, the protrusion 210 sufficiently opens the equator part Se of the lens capsule S forward and backward to prevent the adhesion between the anterior capsule Sf and the posterior capsule Sb of the lens capsule S and the adhesion between the lens capsule S and the intraocular lens 1. be able to. In the present specification, the front-rear diameter of the protrusion 210 refers to the length from the front end to the rear end of the protrusion 210.

また、前記突出部210は、厚みが1.0mm以下で、隣接する突出部210の間隔が0.2mm以上に形成されている。特に好ましくは、突出部210の厚みが0.1mm〜0.5mmで、隣接する突出部210の間隔が0.3mm〜0.9mmに形成されている。これによれば、水晶体嚢Sの前嚢側赤道部Se1と突出部210の接触面積が小さくなるため、前房水Fが水晶体嚢Sの赤道部Seに広い範囲で接することができる。また、眼内レンズ1をインジェクタで眼内に挿入する場合に、インジェクタ内で小さく折り畳み易くなり、折り畳んだ眼内レンズ1を挿入する切開創をより小さくすることができる。   In addition, the protrusion 210 has a thickness of 1.0 mm or less, and an interval between adjacent protrusions 210 is 0.2 mm or more. Particularly preferably, the thickness of the protrusions 210 is 0.1 mm to 0.5 mm, and the interval between the adjacent protrusions 210 is 0.3 mm to 0.9 mm. According to this, since the contact area between the anterior capsule side equator portion Se1 of the lens capsule S and the protruding portion 210 becomes small, the anterior aqueous humor F can contact the equator portion Se of the lens capsule S in a wide range. In addition, when the intraocular lens 1 is inserted into the eye with an injector, the intraocular lens 1 can be easily folded small and the incision wound into which the folded intraocular lens 1 is inserted can be made smaller.

次に、眼内レンズ1を使用した後発白内障および術後細菌性眼内炎の抑制のメカニズムについて説明する。   Next, the mechanism of suppression of post cataract and postoperative bacterial endophthalmitis using the intraocular lens 1 will be described.

本発明の眼内レンズ1を挿入した水晶体嚢S内に挿入した白内障手術の術後において、図11Aに示すように、まず、毛様体Cから分泌された前房水Fは、水晶体嚢Sと虹彩Iの間を通過し、水晶体嚢Sの前嚢Sfの内側に到達する。そして、前房水Fは、一部が虹彩Iの上側に流れる一方、一部が水晶体嚢Sの前嚢Sfの切開部Opから水晶体嚢S内に流入したあと、光学部10の径方向外側に流れる。   After the cataract surgery inserted into the capsular bag S in which the intraocular lens 1 of the present invention is inserted, as shown in FIG. 11A, first, the anterior aqueous humor F secreted from the ciliary body C is the capsular bag S. And between the iris I and the inside of the anterior capsule Sf of the lens capsule S. The anterior aqueous humor F partially flows on the upper side of the iris I, while a part flows into the lens capsule S from the incision Op of the anterior capsule Sf of the lens capsule S and then radially outward of the optical unit 10. Flowing into.

而して、前房水Fは、突出部210の間の凹部220内に流入し、前嚢側赤道部Se1、中央赤道部Se2および後嚢側赤道部Se3を接しながら凹部220内を順に流れる。よって、水晶体嚢Sの赤道部Seに残留する水晶体上皮細胞から分泌され、水晶体上皮細胞の増殖を促すサイトカイン等の化学伝達物質を洗い流すことができる。このため、水晶体嚢Sの赤道部Seにおける水晶体上皮細胞の増殖を抑制し、水晶体上皮細胞の増殖に起因する後発白内障の発生を抑制することが可能となる。   Thus, the anterior aqueous humor F flows into the recesses 220 between the protrusions 210 and sequentially flows through the recesses 220 while contacting the anterior capsule side equator part Se1, the central equator part Se2 and the posterior capsule side equator part Se3. . Therefore, chemical mediators such as cytokines secreted from the lens epithelial cells remaining in the equator Se of the lens capsule S and promoting the proliferation of the lens epithelial cells can be washed away. For this reason, it is possible to suppress the proliferation of lens epithelial cells in the equator Se of the lens capsule S, and to suppress the occurrence of secondary cataract caused by the proliferation of lens epithelial cells.

また、前房水Fは、隣接する突出部210の間の凹部220内を流れたあと、後嚢Sb側にすみやかに流出する。このため、前房水Fが細菌増殖の足場となる眼内レンズ1の光学部10の裏面と後嚢Sbの間の空間Vに流入しやすくなり、術中に空間Vに細菌が持ち込まれた場合でも、流入した前房水Fに含まれるマクロファージなどの免疫系が細菌を死滅させるため、術後細菌性眼内炎の発生を防止することが可能となる。   Further, the anterior aqueous humor F flows through the recesses 220 between the adjacent protrusions 210 and then immediately flows out to the posterior capsule Sb side. For this reason, the anterior aqueous humor F easily flows into the space V between the back surface of the optical part 10 of the intraocular lens 1 and the posterior capsule Sb, which is a scaffold for bacterial growth, and bacteria are brought into the space V during the operation. However, since the immune system such as macrophages contained in the inflowing anterior aqueous humor F kills bacteria, it is possible to prevent the occurrence of postoperative bacterial endophthalmitis.

なお、後嚢Sb側に流出した前房水Fの一部は、再びレンズ支持部20の凹部220内に逆流入したあと、水晶体嚢Sから流出して、虹彩Iの上側を流れるなどして、水晶体嚢S内を循環する。   A part of the anterior aqueous humor F that flows out to the posterior capsule Sb flows back into the concave portion 220 of the lens support portion 20 and then flows out of the lens capsule S and flows above the iris I. Circulates in the capsular bag S.

なお、本実施形態では、レンズ支持部20は、長さ方向に連続的に一体のものに形成したが、図7に示すように、長さ方向に着脱可能に分割されていてもよい。これによれば、術前の超音波生体顕微鏡(UBM)や光干渉断層計(OCT)による計測で予想した水晶体嚢Sの大きさに合わせて術前にレンズ支持部20の長さを変えることができるため、より安定して眼内レンズ1を水晶体嚢S内に係止させることができる。   In this embodiment, the lens support portion 20 is integrally formed continuously in the length direction. However, as shown in FIG. 7, it may be divided so as to be detachable in the length direction. According to this, the length of the lens support portion 20 is changed before the operation in accordance with the size of the lens capsule S predicted by the measurement by the ultrasonic biomicroscope (UBM) or the optical coherence tomography (OCT) before the operation. Therefore, the intraocular lens 1 can be locked in the lens capsule S more stably.

また、レンズ支持部20は、図8Aに示すように、突出部210の前側や外側の周端部211に微細な凹凸が設けられてもよい。また、図8Bに示すように、突出部210の周端部211の全周に亘って微細な凹凸が設けられてもよい。これによれば、水晶体嚢Sの赤道部Seと突出部210の周端部211との間に空間が形成されるため、前房水Fが水晶体嚢Sの赤道部Seに流入しやすくなる。   Further, as shown in FIG. 8A, the lens support portion 20 may be provided with fine irregularities on the front end side or the outer peripheral end portion 211 of the protruding portion 210. Moreover, as shown to FIG. 8B, a fine unevenness | corrugation may be provided over the perimeter of the peripheral edge part 211 of the protrusion part 210. FIG. According to this, since a space is formed between the equator portion Se of the lens capsule S and the peripheral end portion 211 of the protrusion 210, the anterior aqueous humor F easily flows into the equator portion Se of the lens capsule S.

また、前記レンズ支持部20は、図9Aに示すように、基端部21の前側において、レンズ支持部20の長さ方向に延びる第2の凹部250が設けられてもよい。これによれば、前房水Fが水晶体嚢Sの前嚢Sfに接することにより、水晶体嚢Sの前嚢Sfに残留する水晶体上皮細胞から分泌され、水晶体上皮細胞の増殖を促すサイトカイン等の化学伝達物質を洗い流すことができる。   Further, as shown in FIG. 9A, the lens support portion 20 may be provided with a second recess 250 extending in the length direction of the lens support portion 20 on the front side of the base end portion 21. According to this, when the anterior aqueous humor F contacts the anterior capsule Sf of the lens capsule S, it is secreted from the lens epithelial cells remaining in the anterior capsule Sf of the lens capsule S, and chemistry such as cytokines that promote the proliferation of the lens epithelial cells. The transmitter can be washed away.

また、前記レンズ支持部20は、図9Bに示すように、基端部21の前側、外側および後側において、レンズ支持部20の周方向に延びる第2の凹部260が設けられてもよい。これによれば、前房水Fが基端部21近傍の水晶体嚢Sの前嚢Sfおよび赤道部Seに接することにより、基端部21近傍の水晶体嚢Sの前嚢Sfおよび赤道部Seに残留する水晶体上皮細胞から分泌され、水晶体上皮細胞の増殖を促すサイトカイン等の化学伝達物質を洗い流すことができる。   Further, as shown in FIG. 9B, the lens support portion 20 may be provided with a second recess 260 extending in the circumferential direction of the lens support portion 20 on the front side, the outer side, and the rear side of the base end portion 21. According to this, the anterior aqueous humor F contacts the anterior capsule Sf and equator Se of the lens capsule S in the vicinity of the proximal end portion 21, thereby causing the anterior capsule Sf and equator Se of the lens capsule S in the vicinity of the proximal end portion 21. Chemical mediators such as cytokines that are secreted from the remaining lens epithelial cells and promote proliferation of the lens epithelial cells can be washed away.

また、レンズ支持部20は、基端部21の前後径が光学部10の前後径よりも大きく形成されてもよい。これによれば、レンズ支持部20の基端部21が水晶体嚢Sの赤道部Seを前後に十分に開いて、前嚢Sfと後嚢Sbの癒着や眼内レンズ1と水晶体嚢Sの癒着を防止することができる。このため、前房水Fがレンズ支持部20の隣接する突出部210の間を通って、より広い範囲の水晶体嚢の赤道部Seに接することになり、より効果的に後発白内障を抑制することが可能となる。また、前房水Fが眼内レンズ1の裏面との後嚢Sbとの間の空間Vに流入しやすくなり、より効果的に術後細菌性眼内炎の発生を抑制することが可能となる。   The lens support portion 20 may be formed such that the front-rear diameter of the base end portion 21 is larger than the front-rear diameter of the optical unit 10. According to this, the base end portion 21 of the lens support portion 20 sufficiently opens the equator portion Se of the lens capsule S forward and backward, and the adhesion between the anterior capsule Sf and the posterior capsule Sb and the adhesion between the intraocular lens 1 and the lens capsule S. Can be prevented. For this reason, the anterior aqueous humor F passes between the adjacent protrusions 210 of the lens support portion 20 and comes into contact with the equator portion Se of the capsular sac in a wider range, thereby effectively suppressing secondary cataract. Is possible. In addition, the anterior aqueous humor F easily flows into the space V between the back surface of the intraocular lens 1 and the posterior capsule Sb, and can more effectively suppress the occurrence of postoperative bacterial endophthalmitis. Become.

また、突出部210は、環状に形成されるものとしたが、水晶体嚢Sの前嚢側赤道部Se1、中央赤道部Se2および後嚢側赤道部Se3に接するものであれば、その他の形状に形成されてもよい。   Moreover, although the protrusion part 210 shall be formed cyclically | annularly, if it contacts the front capsule side equator part Se1, central equator part Se2, and posterior capsule side equator part Se3 of the lens capsule S, it will be in other shapes It may be formed.

また、レンズ支持部20は、光学部10を前後に移動させることにより焦点調節可能なものであってもよい。具体的には、レンズ支持部20は、基端部21が光学部10の周縁部に可動可能な状態で接続されるとともに、中間部22が水晶体嚢Sの赤道部Seに係止され、水晶体嚢Sの赤道部Seの径方向外側に広がる度合いに応じてレンズ支持部20の中間部22が近接離間方向に移動することにより、基端部21に接続された光学部10が前後方向に移動するものであってもよい。   Further, the lens support unit 20 may be capable of adjusting the focus by moving the optical unit 10 back and forth. Specifically, the lens support portion 20 is connected in a state where the base end portion 21 is movable to the peripheral portion of the optical portion 10, and the intermediate portion 22 is locked to the equator portion Se of the crystalline lens capsule S, so that the crystalline lens The optical part 10 connected to the base end part 21 moves in the front-rear direction when the intermediate part 22 of the lens support part 20 moves in the approaching / separating direction according to the degree of spreading outward in the radial direction of the equator part Se of the sac S. You may do.

<第2の実施形態>
次に、本発明に係る眼内レンズの第2の実施形態について図10を参照しつつ説明する。なお、以下では上記の実施形態と異なる構成についてのみ説明することとし、同一の構成については説明を省略して同一の符号を付すこととする。
<Second Embodiment>
Next, a second embodiment of the intraocular lens according to the present invention will be described with reference to FIG. In the following, only the configuration different from the above embodiment will be described, and the description of the same configuration will be omitted and the same reference numeral will be given.

本実施形態の眼内レンズ2では、前記レンズ支持部20は、図10に示すように、隣接するレンズ支持部20同士が周方向に互いに連結されたリング状に形成されている。これによれば、レンズ支持部20が水晶体嚢Sの赤道部Seの全周に亘って係止されるため、水晶体嚢Sの赤道部Seを全周に亘って確実に拡張して、前嚢Sfと後嚢Sbの癒着や眼内レンズ2と水晶体嚢Sとの癒着を防ぎ、前房水Fが前嚢Sf、水晶体嚢Sの赤道部Seおよび後嚢Sbにより確実に接することができ、より効果的に後発白内障や細菌性眼内炎の発生を抑制することが可能となる。   In the intraocular lens 2 of the present embodiment, as shown in FIG. 10, the lens support portion 20 is formed in a ring shape in which adjacent lens support portions 20 are connected to each other in the circumferential direction. According to this, since the lens support portion 20 is locked over the entire circumference of the equator portion Se of the lens capsule S, the equator portion Se of the lens capsule S is reliably expanded over the entire periphery, and the anterior capsule The adhesion between Sf and posterior capsule Sb and the adhesion between intraocular lens 2 and lens capsule S can be prevented, and anterior aqueous humor F can be reliably contacted by anterior capsule Sf, equator portion Se of lens capsule S and posterior capsule Sb, It becomes possible to suppress the occurrence of secondary cataract and bacterial endophthalmitis more effectively.

以上、図面を参照して本発明の実施形態を説明したが、本発明は、図示した実施形態のものに限定されない。図示された実施形態に対して、本発明と同一の範囲内において、あるいは均等の範囲内において、種々の修正や変形を加えることが可能である。   As mentioned above, although embodiment of this invention was described with reference to drawings, this invention is not limited to the thing of embodiment shown in figure. Various modifications and variations can be made to the illustrated embodiment within the same range or equivalent range as the present invention.

1…眼内レンズ
10…光学部
20…レンズ支持部
21…基端部
22…中間部
23…先端部
200…支持部本体
210…突出部
211…周端部
220…凹部
250、260…第2の凹部
F…前房水
Sf…前嚢
Sb…後嚢
Se…赤道部
Se1…前嚢側赤道部
Se2…中央赤道部
Se3…後嚢側赤道部
Op…前嚢の切開部
L…突出部の前後径
V…眼内レンズの裏面と後嚢の間の空間
DESCRIPTION OF SYMBOLS 1 ... Intraocular lens 10 ... Optical part 20 ... Lens support part 21 ... Base end part 22 ... Intermediate | middle part 23 ... End part 200 ... Support part main body 210 ... Protrusion part 211 ... Peripheral end part 220 ... Concave part 250, 260 ... 2nd Recess F ... Anterior aqueous humor Sf ... Anterior capsule Sb ... Posterior capsule
Se ... Equatorial part Se1 ... Anterior capsule side equator part Se2 ... Central equator part Se3 ... Back capsule side equator part Op ... Incision part L of the anterior capsule V ... Front and back diameter V of the intraocular lens Between the back surface of the intraocular lens and the back capsule space

Claims (11)

白内障手術等において内容物が除去された水晶体嚢内に挿入される眼内レンズであって、
レンズからなる光学部と、該光学部の周縁部に設けられた複数のレンズ支持部とを備え、
前記レンズ支持部は、光学部の周縁部から光学部の周方向に沿って延びる態様で設けられ、少なくとも中間部が水晶体嚢の赤道部に係止され、
水晶体嚢の赤道部に係止される部分の少なくとも前側、外側および後側において、光学部の径方向に延びる態様の突出部がレンズ支持部の長さ方向に沿って複数設けられ、前記突出部の厚みが0.1mm〜1.0mmで、隣接する前記突出部の間隔が0.2mm〜0.9mmに形成され、互いに隣接する突出部の間に前房水が流入することを特徴とする眼内レンズ。
An intraocular lens that is inserted into the lens capsule from which the contents have been removed in cataract surgery, etc.
An optical unit composed of a lens, and a plurality of lens support units provided at the periphery of the optical unit,
The lens support part is provided in a mode extending along the circumferential direction of the optical part from the peripheral part of the optical part, and at least the intermediate part is locked to the equator part of the crystalline lens capsule,
At least the front portion to be engaged in the equatorial region of the capsular bag, the outer and rear protrusions aspect extending in a radial direction of the optical unit is provided with a plurality along the length of the lens supporting portion, the projecting portion The thickness of 0.1 mm to 1.0 mm, the interval between adjacent protrusions is 0.2 mm to 0.9 mm, and the aqueous humor flows between the adjacent protrusions. Intraocular lens.
前記レンズ支持部は、前記突出部の前後径が光学部の前後径よりも大きく形成されている請求項1に記載の眼内レンズ。   The intraocular lens according to claim 1, wherein the lens support portion is formed such that a front-rear diameter of the protrusion is larger than a front-rear diameter of the optical portion. 前記レンズ支持部は、基端部の前後径が光学部の前後径よりも大きく形成されている請求項1または請求項2に記載の眼内レンズ。   The intraocular lens according to claim 1, wherein the lens support portion is formed such that a front-rear diameter of a base end portion is larger than a front-rear diameter of an optical portion. 前記レンズ支持部は、各レンズ支持部を合わせて水晶体嚢の全周の75%以上に亘って赤道部に係止されている請求項1から請求項3までのいずれかに記載の眼内レンズ。   The intraocular lens according to any one of claims 1 to 3, wherein the lens support part is locked to the equator part over 75% or more of the entire circumference of the lens capsule by combining the lens support parts. . 前記レンズ支持部は、隣接するレンズ支持部同士が周方向に互いに連結されたリング状に形成されている請求項1から請求項4までのいずれかに記載の眼内レンズ。   The intraocular lens according to any one of claims 1 to 4, wherein the lens support portion is formed in a ring shape in which adjacent lens support portions are connected to each other in the circumferential direction. 前記レンズ支持部は、基端部の前側において、レンズ支持部の長さ方向に延びる態様の凹部が設けられ、該凹部内に前房水が流入する請求項1から請求項5までのいずれかに記載の眼内レンズ。   6. The lens support portion according to claim 1, wherein a concave portion extending in the length direction of the lens support portion is provided on the front side of the base end portion, and anterior aqueous humor flows into the concave portion. The intraocular lens described in 1. 前記レンズ支持部は、基端部の前側、外側および後側において、レンズ支持部の周方向に延びる態様の凹部が設けられ、該凹部内に前房水が流入する請求項1から請求項5までのいずれかに記載の眼内レンズ。   The lens support portion is provided with a concave portion extending in the circumferential direction of the lens support portion on the front side, the outer side, and the rear side of the base end portion, and an aqueous humor flows into the concave portion. The intraocular lens described in any of the above. 前記レンズ支持部は、長さ方向に着脱可能に分割されている請求項1から請求項7までのいずれかに記載の眼内レンズ。   The intraocular lens according to any one of claims 1 to 7, wherein the lens support portion is divided so as to be detachable in a length direction. 前記レンズ支持部は、前記突出部の少なくとも前側および/または外側の周端部に凹凸が設けられている請求項1から請求項8までのいずれかに記載の眼内レンズ。   The intraocular lens according to any one of claims 1 to 8, wherein the lens support portion is provided with irregularities on at least a front end and / or an outer peripheral end portion of the protrusion. 前記レンズ支持部は、前記突出部の前後径が0.8mm以上で、前記突出部の突出高さが0.2mm以上に形成されている請求項1から請求項9までのいずれかに記載の眼内レンズ。   10. The lens support portion according to claim 1, wherein a front-rear diameter of the protruding portion is 0.8 mm or more and a protruding height of the protruding portion is 0.2 mm or more. Intraocular lens. 前記レンズ支持部は、前記突出部の前後径が1.0mm〜2.0mmで、前記突出部の突出高さが0.3mm〜0.8mmに形成されている請求項10に記載の眼内レンズ。   11. The intraocular device according to claim 10, wherein the lens support portion is formed such that the protrusion has a front-rear diameter of 1.0 mm to 2.0 mm and a protrusion height of the protrusion is 0.3 mm to 0.8 mm. lens.
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KR102222674B1 (en) * 2019-09-04 2021-03-04 인제대학교 산학협력단 Apparatus for fixing intraocular lens including supporting part deformed to T-shape

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