JP5734957B2 - ドーパミンレセプターのオクタヒドロベンゾイソキノリンモジュレーター及びその使用 - Google Patents

ドーパミンレセプターのオクタヒドロベンゾイソキノリンモジュレーター及びその使用 Download PDF

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Publication number
JP5734957B2
JP5734957B2 JP2012507354A JP2012507354A JP5734957B2 JP 5734957 B2 JP5734957 B2 JP 5734957B2 JP 2012507354 A JP2012507354 A JP 2012507354A JP 2012507354 A JP2012507354 A JP 2012507354A JP 5734957 B2 JP5734957 B2 JP 5734957B2
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Prior art keywords
dopamine
compounds
item
alkyl
arch
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JP2012507354A
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Japanese (ja)
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JP2012524796A (ja
JP2012524796A5 (cg-RX-API-DMAC10.html
Inventor
ニコルス，デイヴィッド，アール
ワッツ，ヴァル，ジョセフ
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Purdue Research Foundation
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Purdue Research Foundation
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
JP2012507354A 2009-04-21 2010-04-21 ドーパミンレセプターのオクタヒドロベンゾイソキノリンモジュレーター及びその使用 Expired - Fee Related JP5734957B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17127309P 2009-04-21 2009-04-21
US61/171,273 2009-04-21
PCT/US2010/031916 WO2010124005A1 (en) 2009-04-21 2010-04-21 Octahydrobenzoisoquinoline modulators of dopamine receptors and uses therefor

Publications (3)

Publication Number Publication Date
JP2012524796A JP2012524796A (ja) 2012-10-18
JP2012524796A5 JP2012524796A5 (cg-RX-API-DMAC10.html) 2013-06-06
JP5734957B2 true JP5734957B2 (ja) 2015-06-17

Family

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Family Applications (1)

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JP2012507354A Expired - Fee Related JP5734957B2 (ja) 2009-04-21 2010-04-21 ドーパミンレセプターのオクタヒドロベンゾイソキノリンモジュレーター及びその使用

Country Status (4)

Country Link
US (1) US9359303B2 (cg-RX-API-DMAC10.html)
EP (1) EP2421862B1 (cg-RX-API-DMAC10.html)
JP (1) JP5734957B2 (cg-RX-API-DMAC10.html)
WO (1) WO2010124005A1 (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107011301B (zh) * 2017-05-27 2019-06-28 山东省联合农药工业有限公司 一种2-（2-甲氧基苯基）-5-氧代四氢呋喃-3-羧酸的制备方法
EP4003348B1 (en) 2019-07-30 2024-04-03 Mayo Foundation for Medical Education and Research Compounds and methods for treating fibrotic pathologies
EP4284507A4 (en) * 2021-01-29 2025-01-08 Mayo Foundation for Medical Education and Research Methods of treating ocular fibrotic pathologies

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DK297275A (da) 1974-08-07 1976-02-08 Aspro Nicholas Ltd Isoquinolinderivater
US3939165A (en) 1974-11-14 1976-02-17 Morton-Norwich Products, Inc. 5,6,6A,6B,7,8-Hexahydrobenz[a]phenanthridine hydrochloride
US4346090A (en) 1977-07-21 1982-08-24 Ayerst, Mckenna & Harrison Ltd. 13-Chloro-benzocycloheptapyridoisoquinolines and use as neuroleptics
NL8202467A (nl) 1981-06-18 1983-01-17 Univ Northeastern Oraal-effectieve aporfineverbindingen.
US4678791A (en) * 1985-05-07 1987-07-07 Pennwalt Corporation 6-phenyl-1,2-3,4,4a,5-6,10b-octahydrobenz(h)isoquinolines useful for treating depression
US4737503A (en) 1986-10-08 1988-04-12 Vipont Laboratories, Inc. Method for inhibiting the release of histamine
US5047536A (en) 1989-03-17 1991-09-10 Purdue Research Foundation Hexahydrobenzo(A)phenanthridine compounds
US4963568A (en) 1989-05-31 1990-10-16 Abbott Laboratories Dopamine agonists
US5621133A (en) * 1989-05-31 1997-04-15 Deninno; Michael P. Dopamine agonists
GB8917333D0 (en) * 1989-07-28 1989-09-13 Merck Sharp & Dohme Therapeutic agents
US5180733A (en) * 1990-03-30 1993-01-19 Abbott Laboratories Biogenic amine uptake inhibitors
US5627165A (en) 1990-06-13 1997-05-06 Drug Innovation & Design, Inc. Phosphorous prodrugs and therapeutic delivery systems using same
US5635506A (en) 1990-06-26 1997-06-03 Research Corporation Technologies, Inc. 1, 2-dihydro-3H-dibenzisoquinoline-1,3-dione anticancer agents
IE912999A1 (en) 1990-09-07 1992-03-11 Abbott Lab Phenanthridine compounds
US5266702A (en) 1990-09-19 1993-11-30 Council Of Scientific & Industrial Research 1,3-oxazoline compounds useful as anionic initiators suitable for polymerization of vinyl polymers
US5216018A (en) 1992-02-14 1993-06-01 Du Pont Merck Pharmaceutical Company Hydroisoindolines and hydroisoquinolines as psychotropic
DE69334206D1 (de) 1992-05-26 2008-04-03 Purdue Research Foundation Substituierte hexahydrobenzo(a) phenanthridine
US5438131A (en) 1992-09-16 1995-08-01 Bergstrom; Donald E. 3-nitropyrrole nucleoside
PT690863E (pt) 1993-04-06 2003-07-31 Abbott Lab Compostos tetraciclicos como agonistas da dopamina
US5744476A (en) 1994-06-27 1998-04-28 Interneuron Pharmaceuticals, Inc. Dopamine D1 agonists for the treatment of dementia
WO1996038435A1 (en) * 1995-05-30 1996-12-05 Abbott Laboratories Dopamine agonists
US5554621A (en) * 1995-06-07 1996-09-10 Bristol-Myers Squibb Company Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives
PT845988E (pt) 1995-08-18 2002-05-31 Univ North Carolina Novas isoquinolinas fundidas como ligandos do receptor da dopamina
FR2764890B1 (fr) 1997-06-24 1999-08-27 Adir Nouveaux derives chromeniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
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Also Published As

Publication number Publication date
JP2012524796A (ja) 2012-10-18
WO2010124005A1 (en) 2010-10-28
EP2421862B1 (en) 2014-06-11
EP2421862A1 (en) 2012-02-29
US20120041018A1 (en) 2012-02-16
US9359303B2 (en) 2016-06-07
EP2421862A4 (en) 2012-12-26

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