JP5728632B2 - Method for calibrating occlusion pressure in medical liquid pump and medical liquid pump - Google Patents

Description

  The present invention relates to a method for calibrating the occlusion pressure of a medical chemical pump. More specifically, the present invention relates to a method for calibrating an occlusion pressure in a medical liquid pump and a medical liquid pump capable of improving the safety of chemical liquid administration by setting the occlusion pressure of a chemical liquid channel or the like with high accuracy before the chemical liquid administration.

  In order to accurately administer a chemical solution to a patient, a medical chemical pump is often used. Known medical chemical pumps include infusion pumps that cause chemical liquids to flow by sequentially pressing the chemical liquid tubes in the axial direction, and syringe pumps that store chemical liquids in syringes and cause the chemicals to flow by pushing the pusher. Yes. The syringe pump fixes the syringe outer cylinder at a predetermined position of the syringe pump, and pushes the pusher so as to push the syringe into the syringe outer cylinder via the slider, thereby injecting the drug solution in the syringe outer cylinder. It is comprised so that it may flow in chemical | medical solution flow paths, such as a tube.

  In the medical liquid pump described above, it is required not only to manage the discharge amount of the chemical liquid with high accuracy but also to control the discharge pressure.

  That is, if the drug solution is blocked in the middle of the drug solution flow path and the drug solution cannot be administered, or if the injection pressure to the patient is too high, a serious situation such as giving a patient a disorder occurs. For this reason, a system is often employed in which an alarm is generated or a pump is stopped when a pressure in the chemical liquid flow path or the like is detected and exceeds a predetermined value.

  Moreover, in the syringe pump, it is difficult to directly detect the pressure in the syringe outer cylinder. For this reason, the pushing force of the pusher is measured using a spring, a pressure strain gauge, or the like, and the pressure in the syringe is indirectly monitored to detect a blockage of the infusion flow path or the like. . When the pushing force for pushing the pusher exceeds a predetermined range, an alarm is output or the operation of the syringe pump is stopped.

Japanese Patent Laid-Open No. 7-289638

  In the invention described in the above-mentioned patent publication, the pressure is applied to the pusher when the pressure in the syringe is a predetermined value, the scale factor is obtained, and the occlusion pressure is obtained from the scale factor. Yes. Since the scale factor varies depending on the type of syringe used, parameters that vary depending on the type of syringe are stored in the memory of the syringe pump control device, and occlusion corresponding to various types of syringes using the above parameters. The pressure can be set.

  However, the pushing force of the pusher against the syringe outer cylinder is not only different depending on the size and manufacturer of the syringe, but is also different depending on the type of the chemical solution filled in the syringe outer cylinder and the pushing speed of the pusher. Further, in a syringe filled with a chemical solution, the sliding resistance (friction force) between the gasket and the syringe outer cylinder changes depending on the storage temperature and storage period, and the value of the pushing force of the pusher changes. Therefore, even if the pressing force corresponding to various syringes and chemicals is applied as a table, the pressure in the syringe outer cylinder cannot be controlled with high accuracy.

  In addition, even in an infusion pump in which a chemical solution is flowed by sequentially pressing an infusion tube constituting the chemical solution channel in the axial direction by a peristaltic mechanism, a roller, or the like, the length of the chemical solution channel from the discharge port of the infusion pump to the patient Saga varies, and the type and number of plugs provided on the way are also different. In addition, the flow resistance varies greatly depending on the viscosity of the chemical solution. For this reason, it is difficult to obtain an accurate occlusion pressure with the conventional method for measuring the occlusion pressure in an infusion pump.

  If the pressure set as the occlusion pressure that issues an alarm and stops the pump is high, it will take a long time before the abnormal alarm is output, and during that time it will not be possible to administer the drug solution or a large amount of drug solution will be high pressure to the patient It is also possible that it will be administered. For this reason, in order to improve safety, the control closing pressure is often set low. However, if the control occlusion pressure is set low, depending on the type of the liquid flow path and the chemical solution, the frequency at which an alarm is issued or the pump is stopped increases, which in turn imposes a burden on the patient.

  The present invention has been devised in order to solve the above-described conventional problems. Immediately before a chemical solution is administered to a patient, an occlusion pressure for control is individually set for the chemical solution or liquid flow path to be used. Thus, it is an object of the present invention to provide a method for calibrating the occlusion pressure of a medical liquid pump capable of managing the occlusion pressure with high accuracy and ensuring safety.

The invention described in claim 1 of the present application is a method for calibrating the occlusion pressure in a medical liquid pump for administering a medical liquid to a patient, and a flow path setting step for setting a chemical liquid flow path from the chemical liquid pump to the patient. Before the chemical solution is administered to the patient, the chemical solution flow process for causing the chemical solution to flow into the chemical solution channel at a predetermined flow rate, and the flow pressure of the chemical solution in the chemical solution channel during the chemical solution flow process is measured. Including a flow pressure measurement step, a flow pressure obtained in the flow pressure measurement step, and a control blockage pressure setting step for setting a blockage pressure for control by adding a preset pressure value. After setting the occlusion pressure, the administration of the drug solution to the patient is started, and when the flow pressure measured during the drug solution administration exceeds the control occlusion pressure, an alarm output is generated and / or The liquid pump is one that is configured so as to stop.

  The type of medical chemical pump to which the present invention is applied is not particularly limited, and can be applied to various medical chemical pumps that administer a chemical to a patient via various chemical flow paths such as an infusion tube. it can. For example, the present invention is applied to an infusion pump for flowing a chemical liquid by sequentially pressing a resin tube in the axial direction by a peristaltic mechanism or a syringe pump for flowing a chemical liquid by pushing a pusher of a syringe. it can. The occlusion pressure calibration method according to the present invention can be performed immediately before administering a drug solution to a patient for an infusion tube, a syringe, or the like that is actually used.

  The flow path setting process is performed by providing an actual chemical liquid flow path from the discharge port of the infusion pump to the patient. Specifically, it is performed by setting an infusion tube provided with a constriction plug or the like.

In the present invention, before the drug solution is administered to the patient, a drug solution flow process is performed in which the drug solution is flowed into the drug solution channel at a predetermined flow rate. That is, the flow characteristics of an actual drug solution flow path configured for each individual patient are measured before the drug solution is administered to the patient, and the control occlusion pressure is determined based on the measured value.

  Usually, before the chemical solution is administered, a priming operation is performed to fill the chemical solution flow path constituted by an infusion tube or the like. As in the second aspect of the present invention, it is desirable that the flow pressure measurement step is performed during a priming operation for filling the chemical liquid flow path with the chemical liquid.

  Usually, the priming operation is performed by fast-feeding the chemical solution. However, when the fluid pressure measurement process is performed during the priming operation, the fluid pressure measurement process is caused to flow at the same rate as when the drug solution is administered to the patient, as in the invention described in claim 3. Is preferably performed. As a result, it becomes possible to set the occlusion pressure under the same conditions as when the drug solution is administered to the patient, and it is possible to manage the controlled occlusion pressure with high accuracy.

  Note that the priming at the actual drug solution administration rate is sufficient only during the measurement of the flow pressure. When the flow pressure is not measured, priming can be performed in the fast-forward mode as in the conventional case.

  Moreover, like the invention described in claim 4, in the flow pressure measurement process, the flow pressure with respect to different flow rates of the chemical solution can be measured. Thereby, it is possible to cope with a case where a plurality of drug solution administration rates are used in one drug solution administration.

  As in the fifth aspect of the invention, in the flow pressure measurement step, it is preferable to measure the flow pressure after a predetermined time has elapsed from the start of the flow of the chemical solution or after flowing a predetermined flow rate.

  At the start of starting the chemical liquid pump, the chemical liquid is not filled in the entire area of the chemical liquid flow path, and the mechanical resistance of the pump or the like tends to be larger than in the steady state. In particular, in the syringe pump, the pushing force at the time of starting pushing of the pusher becomes large at the steady time when pushing at a constant speed. By measuring the flow pressure after a predetermined time has elapsed from the start of the flow of the chemical solution or after flowing the predetermined flow rate, the flow pressure at the time of actually administering the chemical solution can be measured with high accuracy.

  Moreover, it is preferable to measure the flow pressure after the said chemical | medical solution flows out from the front-end | tip part of a chemical | medical solution flow path like the invention described in Claim 6. That is, the flow pressure is measured after confirming that the chemical liquid is discharged from the tip of the chemical liquid flow path. As a result, it is possible to measure the flow pressure in a state in which the chemical liquid flows through the entire area of the chemical liquid flow path, and the measurement accuracy of the flow pressure can be increased.

  A flow pressure for control is set to the measured flow pressure in consideration of the kind of chemical solution, the flow speed, and the like. That is, the control blockage pressure is set by adding the flow pressure obtained in the flow pressure measurement step and a preset pressure value. The added flow pressure is stored in the storage means in advance according to the flow rate (administration rate) of the drug solution, the type of the drug solution, the length of the drug channel, etc., and the control block pressure is set. It is desirable that the data is read and used when performing the above.

  After setting the control occlusion pressure, the tip of an infusion tube or the like is connected to the patient, and administration of the drug solution is started. During the administration of the chemical solution, the flow pressure of the chemical solution is measured in the same manner as when the occlusion pressure is calibrated. And when the flow pressure measured during chemical | medical solution administration exceeds the said control obstruction | occlusion pressure, it is comprised so that an alarm output may be generated and / or a chemical | medical solution pump may be stopped. Thereby, it becomes possible to quickly detect that a blockage or the like has occurred and to issue an alarm.

  The invention described in claim 7 determines whether or not the flow pressure detected in the flow pressure measurement step is within a proper flow pressure range set in advance according to the chemical liquid flow path and / or the chemical liquid to be used. The flow path abnormality detection process is performed, and when the measured flow pressure is outside the proper flow pressure range, a flow path abnormality alarm is output.

  As described above, an object of the present invention is to detect the flow pressure of the chemical liquid in the actual chemical liquid flow path with high accuracy and set the clogging pressure with high accuracy. The flow pressure of the chemical solution is within a certain range although it varies depending on the type of the chemical solution, the length of the chemical solution flow path, the type of the piping member on the way, and the like. Therefore, when the flow resistance measured during the flow pressure measurement process according to the present invention is outside the range of the appropriate flow pressure, there is some abnormality in the chemical flow path. The invention described in claim 7 detects abnormality of the chemical liquid flow path by utilizing the flow pressure measurement process in the present invention.

  It is desirable that the range of the appropriate flow pressure is stored in a storage device according to the length of the pipe and the like, and is read and used in the flow path abnormality detection process. Through the flow path abnormality detection process, it is possible to detect an abnormality of the chemical liquid flow path before administering the chemical liquid to the patient, and the safety of the chemical liquid administration can be improved.

  The invention described in claim 8 applies the present invention to a syringe pump. That is, the chemical pump is configured to discharge the chemical liquid in the syringe outer cylinder by moving the pusher of the syringe to flow in the chemical liquid flow path, and to detect the pushing force of the pusher. In a medical syringe pump configured to detect a clogging pressure of a chemical solution, a syringe filled with the chemical solution is attached to a predetermined position of the syringe pump, and the chemical solution flow path from the syringe to the patient is set. A flow path setting process, a chemical liquid flow process for causing the chemical liquid to flow in the chemical liquid flow path by pushing the pusher at a predetermined speed before administering the chemical liquid to the patient; A flow pressure measurement process is provided for determining a flow pressure by measuring a pressing force including a sliding resistance between the pusher and the syringe outer cylinder.

  The syringe pump is configured to control the discharge pressure of the chemical solution by detecting the pushing force of the pusher. The pushing force is detected as a value obtained by adding the flow pressure of the chemical solution and the resistance with which the gasket of the pusher slides in the syringe outer cylinder. Until now, the sliding resistance of the gasket has been set to a fixed value according to the size of the syringe or the like. On the other hand, the sliding resistance changes depending on the temperature, the type of the chemical solution, and the like. Therefore, with the conventional calibration method, it is difficult to set the control occlusion pressure with high accuracy. On the other hand, since the method for calibrating the occlusion pressure according to the present invention is performed before each medicinal solution is actually used after being filled with the medicinal solution, it is possible to manage the occlusion pressure with high accuracy. Become.

  The flow path setting process in the syringe pump is to fix the syringe outer cylinder at a predetermined position of the syringe pump, connect the flange portion of the pusher to the pushing means (slider), and further connect the chemical liquid flow path such as an infusion tube. This is done by connecting to the syringe. In addition, it is preferable to perform the said flow path setting process by mounting | wearing a pump with the syringe of the state which connected the infusion tube which administers a chemical | medical solution, the constriction plug etc. which were provided in the middle. Thereby, it becomes possible to accurately measure the flow pressure of the chemical liquid flow path including various piping members.

  In order to accurately measure the pushing force of the pusher during drug administration, the flow pressure measurement process is performed so that the drug solution flows through the infusion tube connected to the syringe at the same rate as the drug solution is administered to the patient. Further, it is preferable to move the pusher. Further, it is preferable to measure the pushing force after the chemical liquid is discharged from the tip of the chemical liquid flow path.

  Further, in the flow path setting process, it can be configured to identify characteristics such as the capacity of the mounted syringe. That is, as in the invention described in claim 9, in the flow path setting process, the mounted syringe is identified by the syringe identifying means, and in the control closing pressure setting process, the syringe stored in the storage means Characteristic information corresponding to the drug solution flow path and / or the syringe set in the flow path setting process can be read from the characteristic table and used for setting the control blocking pressure.

  Many syringe manufacturers can determine the dimensions of the syringe once the outer diameter of the syringe barrel is known. Other characteristics such as syringe capacity are also found. For example, by measuring the outer diameter of the syringe, the inner diameter, the cross-sectional area, etc. of the syringe outer cylinder are specified, and the flow pressure of the chemical solution in the syringe can be obtained from the pushing force of the pusher. The syringe identification means is not particularly limited. For example, a sensor capable of detecting a rotation angle displacement is provided in the arm portion of the lock mechanism that fixes the syringe outer cylinder so as to press the syringe outer cylinder, and the rotation position of the arm portion that holds the syringe is detected to detect the syringe outer cylinder. Can be detected.

  In addition, in order to easily determine the flow pressure, a syringe identification table in which data of various syringes is tabulated is stored in a storage unit, and addition data corresponding to the identified syringe is added to the measured pushing force. It can be read and the closing pressure (pushing force) for control can be set. In addition, a table with an appropriate range of pressing force including the sliding resistance of the gasket according to the syringe size is provided, and an alarm is issued when the flow resistance measured before the drug solution administration is out of the resistance value range. It can also be configured.

  The sliding resistance of the gasket varies depending on the pushing speed of the pusher as well as the flow resistance of the chemical solution. Therefore, it is preferable that the flow pressure measurement step is performed by pushing the pusher so that the liquid medicine flows through the infusion tube connected to the syringe at the same speed as when the liquid medicine is administered to the patient. In order to accurately measure the pushing force, it is preferable that the tip of the infusion tube is set at a height to be connected to the patient, and the pushing force is measured in a state where the whole area of the infusion tube is filled with the chemical solution.

  Further, as in the case of the invention described in claim 4, when the pushing force for different pushing speeds of the pusher is measured to determine the flow pressure of the liquid medicine, and when a plurality of infusion speeds are used in continuous liquid medicine administration, etc. Can respond.

  Furthermore, it is also possible to obtain the flow pressure of the chemical solution at different pushing speeds of the pusher by continuously changing the pushing speed of the pusher. For example, by gradually increasing the pushing speed of the pusher to the infusion speed in the fast-forward mode where priming is performed, or by gradually reducing the infusion speed from the infusion speed in the fast-forward mode, the change in pushing force during this time is continuously measured. The medicinal solution flow pressure at the required infusion rate for medicinal solution administration can be obtained from the measured value.

  Further, the method for measuring the pushing force is not particularly limited. It can comprise so that it may measure several times and may obtain | require an average value. It is also possible to continuously record the pushing force when the pusher is pushed and to obtain the average value of the recorded pushing forces.

  Further, in the syringe pump, the pushing force at the start of pushing of the pusher is larger than when pushing at a constant speed. For this reason, in the above flow pressure measurement process, the pressing force after the pressing force is pushed for a predetermined distance from the start of pushing and / or the pushing force after the pushing is pushed for a predetermined time from the start of pushing the pusher is measured. It is preferable to configure as described above.

  The control closing pressure is determined by adding a predetermined value to the measured flow pressure (pushing force). In the syringe pump, a pressure obtained by adding the sliding resistance of the gasket to the control closing pressure is measured as the pushing force. Therefore, in the syringe pump, the closing pressure for control can be set by the pushing force, and the flow pressure during drug solution administration can be managed using the pushing force. For this reason, it becomes possible to manage the occlusion pressure with high accuracy.

  When the gasket attached to the syringe outer cylinder or the pusher tip is a defective product, it is difficult to manage the blocking pressure using the pushing force of the pusher. In such defective products, the pushing force of the pusher often becomes abnormally large. For this reason, in the said pushing force measurement process, it becomes possible to detect the said defective product by detecting the abnormal value of the said pushing force.

  That is, as in the invention described in claim 10, whether or not the pushing force detected in the flow pressure measurement process is within an appropriate range set in advance according to the syringe and / or the chemical liquid flow path to be used. It is preferable that a flow path abnormality alarm is output when the measured pushing force is out of the appropriate range.

  The appropriate range of the pressing force can be obtained by measuring the pressing force of a large number of syringes and performing statistical processing. Whether or not each syringe can be applied to a syringe pump can be detected by the above-described syringe abnormality detection process before administration of the drug solution, and the safety of the drug solution administration can be improved.

  According to an eleventh aspect of the present invention, there is provided a pump mechanism for causing a chemical liquid to flow in the chemical liquid flow path, a flow pressure measuring device capable of measuring a flow pressure of the chemical liquid flowing in the chemical liquid flow path, the pump mechanism, and the flow pressure measurement. A medical chemical pump that administers a chemical solution to a patient through a set chemical solution flow path, and the control device is configured to control the device before administering the chemical solution to the patient. A clogging pressure setting means for causing the chemical liquid to flow into the chemical liquid flow path at a predetermined flow rate, causing the flow pressure measuring device to measure the flow pressure of the chemical liquid, and setting a control clogging pressure based on the measured flow pressure; After the control blockage pressure is set, administration of the drug solution to the patient is started, and an alarm is output when the flow pressure measured during the drug solution administration exceeds the control blockage pressure. Configured with by generating and / or a flow path abnormality detecting means for stopping the liquid chemical pump.

  In the invention described in claim 12, the medical liquid pump includes a syringe holding means for holding a syringe outer cylinder, and a slider for pushing a pusher into the syringe outer cylinder held by the syringe holding means, A medical syringe pump that administers a drug solution in the syringe outer cylinder to a patient via an infusion tube, and includes syringe detection means for detecting the size and type of the syringe, a syringe used, and a liquid flow path. From the storage means for storing the predetermined characteristic value according to the above, the pushing force detecting means for measuring the pushing force of the pusher, the pushing force and the characteristic value measured by the pushing force detecting means, the control blockage An occlusion pressure setting means for setting the pressure, and an alarm is output and / or the syringe pump is stopped when the pushing force measured during the administration of the drug solution exceeds the control occlusion pressure. Configured with a cell passage abnormality detecting means.

  In a thirteenth aspect of the present invention, the pressing force detected before the drug solution is administered to the patient is within a predetermined pressing force range stored in the storage means corresponding to the syringe and the liquid channel to be used. Is provided with a flow path abnormality detecting means for outputting a flow path abnormality alarm.

  The occlusion pressure in the syringe pump can be detected with high accuracy, and the safety of drug administration can be enhanced.

It is a front view of a syringe pump to which the present invention is applied. It is a top view of the syringe pump shown in FIG. It is a figure which shows the state which is measuring pushing force. It is a figure which is administering the chemical | medical solution with respect to a patient. It is a flowchart which shows an example of the calibration method which concerns on this invention. It is a flowchart which shows an example of the calibration method which concerns on this invention. It is a figure which shows the form of a syringe.

  Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.

  The syringe 2 according to the present invention includes an outer cylinder 3 that stores a chemical solution, an oblong flange portion 5 that extends outward in the radial direction at the base end portion of the outer cylinder 3, and the above-described base end portion. And a pusher 4 inserted into the outer cylinder. The syringe 2 is entirely formed by resin molding. A discharge port 3 a to which the infusion tube 21 is connected is formed at the distal end portion of the outer cylinder 3. Further, as shown in FIG. 7B, a gasket 4a is provided at the distal end of the pusher 4 so as to seal the space between the inner surface of the outer cylinder 3 and at the pusher proximal end. The pusher flange portion 13 is provided.

  The syringe 2 according to the present embodiment is provided with a calibration pushing region H for measuring the pushing force for calibration by pushing the syringe. The calibration pushing region H may be set so that the pushing force can be measured in a state where the chemical solution flow path connected to the syringe 2 is filled with the chemical solution. In the conventional syringe, since the amount of the chemical liquid that can perform the priming operation is filled, the pushing force can be measured when performing the priming operation, but the length of the chemical liquid flow path is long. In this case, it is necessary to set the calibration push area large.

  As the syringe, a disposable syringe 2 filled with a chemical in an outer cylinder is often used. As shown in FIG. 7A, a cap 20 is attached to the discharge port 3a and the pusher The gasket 4 a is inserted up to the pushing start position of the pusher, and the chemical solution is sealed in the outer cylinder 3.

  The syringe pump 1 holds and pushes the syringe outer cylinder holding means 6.9 and 12 for holding the outer cylinder 3 of the syringe 2 and the flange portion 13 provided at the proximal end portion of the pusher 4. The pushing means 10 for discharging the chemical solution is provided.

  The syringe outer cylinder holding means according to the present embodiment includes an outer cylinder holding portion 6 configured by providing a mounting surface 6a having a substantially cylindrical inner surface on which an outer surface of the syringe outer cylinder 3 can be mounted on the upper surface of the housing of the syringe pump. The flange holding groove 9 formed between the standing wall portions 7 and 8 provided on the base end side of the outer cylinder holding portion 6 and capable of inserting and latching the flange portion 5 and the syringe outer cylinder 3 are placed above. A pinching lock mechanism 12 capable of pinching and holding the surface 6a is provided.

  The pushing means 10 includes a slider 10a configured to move in the axial direction by rotating a driving screw (not shown) by a motor. The slider 10a holds the flange portion 13 of the pusher 4 and pushes it in the axial direction to discharge the chemical solution stored in the syringe outer cylinder 3 from the discharge port 3a.

  The pinching lock mechanism 12 includes an arm portion 12a that holds and holds the syringe outer cylinder 3 with the placement surface 6a. The arm portion 12a is configured to be able to pinch the syringe outer cylinder 3 elastically. Moreover, in this embodiment, the said pinching lock mechanism 12 comprises the syringe detection means which can detect the magnitude | size of the syringe 2 by detecting the rotation angle of the said arm part 12a.

  The syringe detection means includes a variable resistor (not shown) that changes resistance according to the rotation angle of the arm portion 12a, and a syringe data table that corresponds to the detection resistance of the variable resistor. The outer diameter of the syringe outer cylinder is measured by the detection resistance of the variable resistor, and the syringe capacity, inner diameter, and the like corresponding to the outer diameter can be read from the syringe data table.

  Further, an appropriate portion of a driving mechanism (not shown) for driving the slider 10a is provided with a pressing force detection means (not shown) capable of measuring the pressing force of the pusher 4. For example, the pressing force detecting means may include an elastic piece (not shown) that is elastically deformed by the pressing force from the pusher, and a resistance strain gauge attached to the elastic piece. The pushing force of the pusher can be detected using the output from the resistance strain gauge. It should be noted that various forms of strain gauges can be employed as the pushing force detection means.

  Hereinafter, a method for calibrating the occlusion pressure according to the present embodiment will be described with reference to FIGS.

  After the switch of the syringe pump is turned on (S101), a flow path setting step (S102) for mounting the syringe pump 1 and the like on the syringe 2 filled with the chemical solution is performed. The flow path setting step (S102) is a step of setting a chemical flow path reaching the patient 40 by connecting the tube 21 or the like to the syringe 2 shown in FIG. In this embodiment, the syringe outer cylinder 3 is fixed to the upper surface of the syringe pump 1 by the syringe outer cylinder holding means 6.9 and 12, and the three-way plug 23 and the other link plug 24 are attached to appropriate portions of the tube 21. It is done by providing.

  The flow path setting step sets a flow path up to the patient 40, but the occlusion pressure described below is calibrated without connecting the flow path to the patient.

  After finishing the flow path setting process, it is determined whether or not the syringe 2 is properly attached (104). If the syringe 2 is not properly mounted, an alarm is output (S103), and the syringe needs to be mounted again. For example, when the syringe is mounted in a tilted state, the alarm is issued and the calibration is performed so that the next stroke cannot be performed.

  After confirming that the syringe has been properly mounted (YES in S104), the type of the mounted syringe 2 is identified by the syringe detection means. Specifically, as described above, the size of the syringe is specified from the outer diameter of the syringe outer cylinder 3, and syringe data is read from the characteristic table described above (S106). The syringe data is displayed on the display unit, and it can be confirmed whether or not the syringe is misidentified. The syringe data includes the inner diameter of the attached syringe outer cylinder and the standard sliding resistance of the gasket, and is used in the following process described below.

  Thereafter, the chemical solution discharge speed (administration speed), the administration time, etc. are set according to the chemical liquid to be administered, the volume of the syringe, and the like (S107).

  After the chemical solution discharge speed and administration time are set, the priming operation is started (S108). The priming operation is performed to fill the infusion tube 21 with a chemical solution and exclude air.

  In this embodiment, when performing the said priming operation, it is comprised so that the pushing force of the pushing element 4 of the mounted syringe 2 may be measured.

  The pushing force of the pusher is obtained by adding the sliding resistance (frictional force) between the pusher gasket and the inner wall of the outer cylinder and the flow resistance in the infusion tube of the chemical solution. In order to accurately measure the pushing force at the time of actual drug administration, it is preferable that the flow path and the administration speed be the same as those for administering the drug to the patient.

  That is, as shown in FIG. 3, it is desirable to measure the pushing force while holding the tip of the infusion tube 21 at a height corresponding to the administration site of the patient. If the height is different, gravity acts on the chemical solution and the pushing force cannot be measured accurately.

  Moreover, it is necessary to measure the pushing force when actually administering the drug solution. The conventional priming operation is performed in order to fill the infusion tube with the chemical solution and expel air, and is often performed in the fast-forward mode where the flow rate of the chemical solution is large. In the present embodiment, at least during the measurement of the pushing force, the pusher 4 is pushed at a pushing speed at which the drug solution is actually administered. The pushing force can be measured in a short time, and the time required for the priming operation does not increase greatly.

  It is desirable to measure the pressing force after a predetermined time has elapsed from the start of pushing of the pusher 4 or after a predetermined distance has been pushed from the start of pushing (S109, S110). This is because the pushing force at the start of pushing of the pusher increases the frictional force between the gasket and the inner surface of the outer cylinder, so that the pushing force at the time of actual drug administration may not be accurately detected.

  Furthermore, as shown in FIG. 3, it is more preferable to employ a pressing force measured after the chemical solution is dropped from the tip of the flow path. As a result, it becomes possible to measure the pushing force when the chemical liquid is made to flow over the entire flow path, and the calibration accuracy of the occlusion pressure is increased. In addition, in the process where the chemical liquid is filled in the flow path, the pushing force increases proportionally. Therefore, when the length of the flow path or the like is known, before the chemical liquid is dropped from the front end of the flow path, The pushing force can also be measured.

  Moreover, the aspect which measures the said pushing force is not specifically limited, either. For example, the pushing force can be measured a plurality of times during pushing and the average value can be obtained and used as control blockage pressure setting data. Further, it is possible to detect a change in the pushing force from the start of pushing of the pusher and adopt the pushing force in a region where the pushing force is stable.

  Next, a flow path abnormality detection process for determining whether or not the measured pushing force is within an appropriate range read from the syringe characteristic table is performed (S111). When the measured pushing force is abnormally large or abnormally small, the syringe 2 or a member installed in the flow path often has an abnormality. Moreover, the case where abnormality has arisen in the pushing means of the syringe pump 1 is also considered. By performing the flow path abnormality detection process, it is possible to detect whether there is an abnormality in the attached syringe or syringe pump.

  If an abnormality is detected in the flow path abnormality detection process (S111) (YES in S111), an alarm is output and the apparatus stops. Thereby, before administering a medical solution to a patient, it becomes possible to exchange a syringe, an infusion tube, etc., and can improve safety.

  On the other hand, if there is no abnormality in the syringe (NO in S111), the pressing force preset in correspondence with the various syringes installed (multiplied by the predetermined flow pressure value and the syringe cross-sectional area) from the syringe characteristic table ) Is read out, and a control closing pressure setting step for adding to the measured pushing force is performed. The control blocking pressure according to the present embodiment is handled as the pushing force of the pusher corresponding to the blocking pressure at which the administration of the chemical solution should be stopped. Thereby, the calibration of the occlusion pressure is completed (S116). The control blocking pressure is stored in the control memory of the syringe pump 1 and is used for the next control during drug administration.

  After the calibration of the occlusion pressure is finished, the administration of the drug solution to the patient 40 is started (S117). As shown in FIG. 4, the drug solution is administered by connecting the distal end portion 22 of the infusion tube 21 to a predetermined site of the patient 40 and then pressing a predetermined start button or the like.

  During the drug solution administration, the pushing force of the pusher 4 is continuously measured. When the pushing force exceeds the control closing pressure (pushing force) described above, an alarm is output (S119) and the apparatus is stopped (S120).

  On the other hand, when the pushing force is equal to or less than the control blockage resistance, the administration of the medicinal solution is continued, the set predetermined administration time has elapsed, or the set amount of medicinal solution is administered, and the administration of the medicinal solution is performed. Ends.

  In the present embodiment, the pushing force of each syringe filled with a chemical solution to be administered to a patient can be measured immediately before the chemical solution administration. For this reason, it becomes possible to set the obstruction | occlusion pressure corresponding to each syringe with high precision.

  Moreover, it becomes possible to identify whether or not the pushing force of the syringe is abnormal before administering the drug solution. Thereby, it becomes possible to check abnormality of a syringe or a syringe pump, and the safety | security of chemical | medical solution administration increases markedly.

  In the above-described embodiment, the present invention is applied to a syringe pump. However, the present invention can also be applied to a chemical pump in which an infusion tube is sequentially pressed and deformed in the axial direction by a peristaltic mechanism or a roller to flow the chemical liquid.

  In the chemical liquid pump of the said form, it is often calibrated so that the flow pressure of a chemical liquid is measured in the middle of a chemical liquid flow path. Therefore, the occlusion pressure can be calibrated on the basis of the actual flow pressure of the chemical solution.

  It is possible to remarkably improve the safety of drug administration in the medical drug pump.

1 Syringe pump (medical liquid pump)

2 Syringe 4 Pusher 3 Syringe outer cylinder

Claims (13)

A method for calibrating occlusion pressure in a medical drug pump for administering a drug solution to a patient, comprising:
A flow path setting step for setting a chemical flow path from the chemical pump to the patient;
Before administering the chemical solution to the patient, a chemical fluid flow step for causing the chemical solution to flow into the chemical fluid flow path at a predetermined flow rate;
A flow pressure measurement step for measuring a flow pressure of the chemical solution in the chemical flow channel during the chemical solution flow step;
Including the flow pressure obtained in the flow pressure measurement step and a control blockage pressure setting step of setting a control blockage pressure by adding a preset pressure value,
After setting the control occlusion pressure, the administration of the drug solution to the patient is started, and an alarm output is generated when the flow pressure measured during the drug solution administration exceeds the control occlusion pressure, and / or Or the occlusion pressure calibration method in the medical chemical pump configured to stop the chemical pump.
  2. The method for calibrating a clogging pressure in a medical chemical pump according to claim 1, wherein the flow pressure measurement step is configured to be performed during a priming operation for filling the chemical solution in the chemical solution flow path.   3. The medical chemical solution according to claim 1, wherein the flow pressure measurement step is performed by causing the chemical solution to flow through the chemical solution flow path at the same rate as when the chemical solution is administered to a patient. Method for calibrating occlusion pressure in a pump.   The method for calibrating the occlusion pressure in the medical liquid pump according to any one of claims 1 to 3, wherein in the flow pressure measurement step, the flow pressure with respect to different flow rates of the chemical liquid is measured.   The medical pressure according to any one of claims 1 to 4, wherein, in the flow pressure measurement step, the flow pressure is measured after a predetermined time has elapsed from the start of the flow of the chemical solution or after a predetermined flow rate is flowed. Method for calibrating occlusion pressure in a chemical pump.   The clogging pressure calibration method for a medical chemical liquid pump according to any one of claims 1 to 5, wherein a flow pressure after the chemical liquid flows out from a tip portion of the chemical liquid flow path is measured. Including a flow path abnormality detection process for determining whether or not the flow pressure detected in the flow pressure measurement process is within an appropriate flow pressure range set in advance according to the chemical flow path and / or the chemical used,
The blockage in the medical liquid pump according to any one of claims 1 to 6, configured to output a flow path abnormality alarm when the measured flow pressure is outside the proper flow pressure range. Pressure calibration method. The chemical liquid pump causes the chemical liquid in the syringe outer cylinder to be discharged by moving the pusher of the syringe to flow in the chemical liquid flow path, and detects the pushing force of the pusher, thereby A medical syringe pump configured to detect occlusion pressure,
A flow path setting step for setting a chemical liquid flow path from the syringe to the patient while mounting a syringe filled with the chemical liquid at a predetermined position of the syringe pump;
Before administering the drug solution to the patient, a drug solution flow step of pushing the pusher at a predetermined speed to flow the drug solution in the drug solution channel;
8. The flow pressure measurement step of obtaining a flow pressure by measuring a pressing force including a sliding resistance between the pusher and the syringe outer cylinder during the chemical liquid flow step. The occlusion pressure measuring method in the medical chemical pump according to any one of the preceding claims. In the above flow path setting process, the mounted syringe is identified by the syringe identification means,
In the control blockage pressure setting process, the characteristic information corresponding to the chemical liquid channel and / or the syringe set in the channel setting process is read from the syringe characteristic table stored in the storage unit, and the control The method for measuring an occlusion pressure in a medical liquid pump according to claim 8, which is used for setting an occlusion pressure. Including a flow path abnormality detection process for determining whether or not the pushing force detected in the flow pressure measurement process is within a range set in advance according to the syringe and / or the chemical flow path used,
The method for calibrating the occlusion pressure in the medical chemical pump according to claim 9, configured to output a flow path abnormality alarm when the measured pushing force is out of the range. A pump mechanism for causing the chemical liquid to flow in the chemical liquid flow path;
A flow pressure measuring device capable of measuring the flow pressure of the chemical liquid flowing through the chemical liquid flow path;
A medical chemical pump that includes the pump mechanism and a control device that controls the flow pressure measuring device, and that administers a chemical to a patient via a set chemical flow channel,
The control device
Before the drug solution is administered to the patient, the drug solution is caused to flow into the drug solution flow path at a predetermined flow rate, and the flow pressure measuring device is configured to measure the flow pressure of the drug solution, and control is performed based on the measured flow pressure. Blockage pressure setting means for setting the blockage pressure for use;
After setting the control occlusion pressure, the administration of the drug solution to the patient is started, and an alarm output is generated when the flow pressure measured during the drug solution administration exceeds the control occlusion pressure, and / or Alternatively, a medical chemical pump comprising a flow path abnormality detecting means for stopping the chemical pump. The medical chemical pump includes a syringe holding unit that holds a syringe outer cylinder, and a slider that pushes a pusher into the syringe outer cylinder held by the syringe holding unit, and the medical liquid in the syringe outer cylinder is A medical syringe pump that administers to a patient via a chemical flow path,
Syringe detection means for detecting the size and type of the syringe;
Storage means for storing predetermined characteristic values according to the syringe and the liquid flow path used;
A pushing force detecting means for measuring the pushing force of the pusher;
A blocking pressure setting means for setting the control blocking pressure from the pressing force measured by the pressing force detection means and the characteristic value;
The medical medicinal solution according to claim 11, further comprising a flow path abnormality detecting means for outputting an alarm and / or stopping the syringe pump when the pushing force measured during the administration of the medicinal solution exceeds the control blocking pressure. pump.   An abnormality alarm is output when the pushing force detected before the medicinal solution is administered to the patient exceeds a predetermined pushing force range stored in the storage unit corresponding to the syringe and the liquid flow path to be used. The medical chemical pump according to claim 12, comprising a flow path abnormality detection means.

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