JP5709473B2 - Biological tissue adhesive applicator - Google Patents

Description

  The present invention relates to a biological tissue adhesive applicator.

  For humans or animals, biological tissue adhesives adhere strongly to the surface of biological tissue to prevent fluid leaks (blood, cerebrospinal fluid, pancreatic fluid, etc.) and air leaks (pneumothorax), seals at the cleavage site, sutures Widely used for reinforcement, covering defective structures, etc. A biological tissue adhesive mainly composed of animal protein is formed in situ by mixing a protein solution and a coagulation factor solution that promotes the formation of a coagulum of the protein. When this type of biological tissue adhesive is used, for example, when a solution containing fibrinogen is mixed with a thrombin-containing solution, and this is used for biological tissue adhesion, conventionally, one solution is applied to the application site. The other solution was coated with the other solution, or the two solutions were mixed in advance in a mixed solution, sucked into a syringe, and then applied to the site to be bonded.

  However, the first method has a problem that the solidification of the surface occurs before the two solutions are completely mixed, resulting in incomplete mixing, and hence a decrease in adhesive strength. In the second method, since the adhesive solidifies immediately after mixing the two solutions, the adhesive must be applied to the application site immediately after mixing the two solutions, and requires considerable skill. Even if it can be applied, there is a problem that the application site is limited.

  Therefore, when a fibrinogen-containing solution is mixed with a thrombin-containing solution, due to the above problems, each solution is stored in advance in two syringes, and the two solutions stored in these syringes are poured out simultaneously. Further, a method in which two solutions are atomized and mixed by injecting sterile gas into the mixing portion and applied to the target affected part is used (see, for example, Patent Document 1).

Japanese Patent Laid-Open No. 2001-238887

  However, a phenomenon of clogging at the tip has often occurred as a failure using this device. This occurs especially when intermittently used, and the cause is that the atomized fine particles of fibrinogen solution and thrombin solution are reflected from the surgical field during spraying and come into contact with different solutions at the tip of the nozzle tip. Clogging occurred as solidification progressed. Further, when the interruption time is long, clogging may occur due to drying due to contact with the atmosphere. In this case, it goes without saying that the device must be replaced, and particularly expensive preparations have been wasted. In the gelatin used as the biological tissue adhesive in the present invention, there was no appropriate applicator.

  The present invention has been made to solve such problems, and an object of the present invention is to provide a biological tissue adhesive applicator that is less likely to be clogged.

The object of the present invention is to provide a syringe outer cylinder having a mouth portion protruding from the tip, a gasket inserted into the syringe outer cylinder, and an operation for moving the gasket along the longitudinal direction of the syringe outer cylinder. A living body comprising a first syringe and a second syringe each having a pusher to be filled, and a space formed by each syringe outer cylinder and each gasket filled with a liquid for a biological tissue adhesive having a different liquid composition A tissue adhesive applicator, which is formed of a heating means capable of heating the first syringe and the second syringe , and a heat conductive material, and is provided at least on each syringe outer cylinder of the first syringe and the second syringe. A holding part for holding a part, and a first pipe line and a second pipe line connected to each of mouth parts of the syringe outer cylinders of the first syringe and the second syringe, The holding portion is attached to the holding portion main body in which a mounting recess in which at least a part of each of the syringe outer cylinders of the first syringe and the second syringe is placed, and to be freely opened and closed with respect to the holding portion main body. And a holding portion lid body that is formed with a covering recess that covers the exposed surface of each of the mounted syringe outer cylinders, and is provided inside at least one of the holding portion main body and the holding portion lid body. The heating means is installed, and the heating means indirectly heats the first syringe and the second syringe by heating at least one of the holding part main body and the holding part lid, the holding portion surrounds a periphery of the first conduit and the second conduit, provided with a surrounding body formed of a thermally conductive material, wherein the enclosure is connected to the holding portion, the holding Part main body or the holding part lid By being heated by et heat transfer is achieved by the biological tissue adhesive applicator for indirectly heating the first conduit and the second conduit.

  Thus, it is effective that the liquid stored in the first syringe or the second syringe is solidified by including the heating means for heating at least one of the first syringe and the second syringe. Can be prevented. In particular, when the liquid stored in the first syringe (or the second syringe) is a liquid containing gelatin, the liquid gels at room temperature, but gels by heating with heating means. The liquid can be changed into a low-viscosity solution, and can be applied to the affected area of the patient while preventing clogging.

Further, the holding unit includes a holding unit main body on which the syringe outer cylinders of the first syringe and the second syringe are placed, and a holding unit lid that is attached to the holding unit main body so as to be freely opened and closed. When it does, it becomes possible to install and remove a 1st syringe and a 2nd syringe easily. In addition, since the heating body is installed inside at least one of the holding part main body and the holding part lid, the holding part main body and the holding part lid can be reliably and efficiently heated. As a result, the liquid stored in the first syringe and the second syringe can be effectively prevented from solidifying. In addition, by heating the solidified liquid, the state can be changed to a solution having a low viscosity, and clogging can be prevented from occurring.

In addition, according to the configuration in which the holding unit includes an enclosure formed of a thermally conductive material surrounding the first pipe line and the second pipe line, and the enclosure is connected to the holding unit, The heat of the heated holding part is efficiently transmitted to the surrounding body. Since the heat transmitted to the enclosure is dissipated toward the first and second pipes disposed inside the enclosure, the inside of the first and second pipes that are likely to be clogged due to solidification. The liquids L1 and L2 can be effectively heated, and clogging due to solidification of the liquid can be prevented.

  Moreover, it is preferable that the said enclosure is provided with the heat exchanger plate arrange | positioned between a 1st pipe line and a 2nd pipe line.

  By providing a heat transfer plate formed of a material having excellent thermal conductivity between the first pipe line and the second pipe line inside the enclosure, the enclosure connected to the holding part and the holding part Thus, the heat generated by the heating means is transmitted to the heat transfer plate. Since the heat transmitted to the heat transfer plate is dissipated, the first and second pipes disposed in the vicinity of the heat transfer plate can be efficiently heated, and the first pipe and the second pipe are inside. It is possible to more effectively prevent the liquids L1 and L2 from solidifying and clogging.

  Moreover, it is preferable that a covering body that integrally covers both tip portions of the first pipe line and the second pipe line is provided, and the covering body is formed of a heat conductive material.

  According to such a configuration, the covering body efficiently receives the heat radiated from the surrounding body and the heat radiated by the heat transfer plate. The covering body dissipates the received heat to the liquid in the both ends of the first pipe and the second pipe, so that the liquid in the both ends of the first pipe and the second pipe is efficiently discharged. It becomes possible to heat. Since both the front ends of the first pipe and the second pipe are disposed in the vicinity of the opening 453 at the front end of the enclosure, they are affected by outside air and are likely to be clogged due to solidification. Further, it becomes possible to prevent clogging at the portion by effective heating by the covering.

  Moreover, it is preferable that one of the liquids for biological tissue adhesives having different liquid compositions is a liquid containing gelatin and the other is a liquid for solidifying gelatin.

  ADVANTAGE OF THE INVENTION According to this invention, the biological tissue adhesive applicator which is hard to generate | occur | produce clogging can be provided.

It is a schematic structure top view of the biological tissue adhesive applicator which concerns on one Embodiment of this invention. It is a schematic structure side view of a biological tissue adhesive applicator according to an embodiment of the present invention. It is AA sectional drawing of FIG. FIG. 1 is a plan view showing a state in which the holding unit lid 422 and the surrounding upper part 452 connected to the holding unit lid 422, the first syringe 2, the second syringe 3, the first pipe 213, and the second pipe 313 are removed. FIG. It is a fragmentary longitudinal cross-sectional view of the 1st syringe (2nd syringe) with which the biological tissue adhesive applicator shown in FIG. 1 is loaded. It is BB sectional drawing of FIG. It is a schematic structure sectional view showing a modification of the living tissue adhesive applicator shown in FIG. FIG. 7 is a schematic cross-sectional view showing another modification of the biological tissue adhesive applicator shown in FIG. 1.

  Hereinafter, a biological tissue adhesive applicator according to the present invention will be described with reference to the accompanying drawings. FIG. 1 is a schematic configuration plan view of a biological tissue adhesive applicator 1 according to an embodiment of the present invention, and FIG. 2 is a schematic configuration side view. 3 is a cross-sectional view taken along the line AA in FIG. 1. FIG. 4 shows the holding unit lid 422 shown in FIG. 1, the surrounding upper part 452 connected to the holding unit lid 422, the first syringe 2, and the second syringe 3. FIG. 3 is a plan view showing a state where a first pipeline 213 and a second pipeline 313 are removed. Each drawing is partially enlarged or reduced to facilitate understanding of the configuration, not the actual size ratio.

  The biological tissue adhesive applicator 1 according to the present invention applies two types of liquids (first liquid L1 and second liquid L2) having different liquid compositions while mixing them. As shown in FIGS. 1 to 4, the biological tissue adhesive applicator 1 includes a first syringe 2 that stores a first liquid L1, a second syringe 3 that stores a second liquid L2, and a first syringe. An applicator main body 4 on which the syringe 2 and the second syringe 3 are loaded, and an operation means 5 are provided.

  First, the configuration of the first syringe 2 and the second syringe 3 will be described. Since the 1st syringe 2 and the 2nd syringe 3 are the substantially the same structures, the 1st syringe 2 is demonstrated typically.

  As shown in FIG. 5, the first syringe 2 in the present embodiment includes a syringe outer cylinder 21, a gasket 22 that is inserted into the syringe outer cylinder 21 and can slide within the syringe outer cylinder 21, and the gasket 22 is a syringe. A pusher 23 (plunger rod) that is moved along the longitudinal direction (axial direction) of the outer cylinder 21 is provided. The gasket 22 is connected to the tip of the pusher 23.

  The syringe outer cylinder 21 is composed of a bottomed cylindrical member, and a mouth portion 211 whose diameter is reduced with respect to the body portion of the syringe outer cylinder 21 is integrally formed at the center of the bottom end of the syringe. Yes.

  A flange 212 is integrally formed on the outer periphery of the rear end of the syringe outer cylinder 21, and a scale indicating the amount of liquid is attached to the outer peripheral surface of the syringe outer cylinder 21.

  Examples of the constituent material of the syringe outer cylinder 21 include polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, and acrylonitrile-butadiene-styrene copolymer. And various resins such as polyesters such as polyethylene terephthalate and polyethylene naphthalate, butadiene-styrene copolymers, and polyamides (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12). Resins such as polypropylene, cyclic polyolefin, and polyester are preferred because they are easy to mold and have low water vapor permeability. In addition, it is preferable that the constituent material of the syringe outer cylinder 21 is substantially transparent in order to ensure the internal visibility.

  The gasket 22 inserted (accommodated) in the syringe outer cylinder 21 is made of an elastic material. A plurality (two) of ring-shaped protrusions 221 are formed on the entire outer periphery of the gasket 22, and these protrusions 221 slide while being in close contact with the inner peripheral surface of the syringe outer cylinder 21. As a result, liquid-tightness can be more reliably maintained and slidability can be improved.

  The gasket 22 is formed with a hollow portion 222 that opens to the rear end surface thereof, and a head portion 232 of the pusher 23 described later is installed in the hollow portion 222.

  The constituent material of the gasket 22 is not particularly limited. For example, various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, polyester, polyamide, Examples thereof include elastic materials such as various thermoplastic elastomers such as olefins and styrenes, or mixtures thereof.

  The pusher 23 has a rod-like main body portion 231 whose cross section has a cross shape. A head portion 232 that is inserted into the hollow portion 222 of the gasket 22 and connected to the gasket 22 is formed on the distal end side of the main body portion 231. The gasket 22 and the head portion 232 can be connected by various methods. For example, a female screw may be formed on the inner peripheral surface of the hollow portion 222 of the gasket 22, a male screw may be formed on the outer peripheral surface of the head portion 232, and both may be connected by screwing the male screw with the female screw. Good. In addition, the connection is not limited to screwing, but may be, for example, a structure connected by uneven fitting, a structure fixed by adhesion, fusion, or the like, or an integrally formed structure.

  A disc-shaped flange 233 is formed on the rear end side of the main body 231. As a constituent material of the pusher 23, the same materials as those exemplified as the constituent material of the syringe outer cylinder 21 can be used.

  Before the first syringe 2 is loaded into the applicator main body 4, the space surrounded by the syringe outer cylinder 21 and the gasket 22 (liquid storage space) is filled with the first liquid L <b> 1.

  Similar to the first syringe 2, the second syringe 3 includes a syringe outer cylinder 31, a gasket 32 that can slide within the syringe outer cylinder 31, and a pusher 33 that moves and operates the gasket 32. A space surrounded by the cylinder 31 and the gasket 32 is filled with the second liquid L2. Since the structure of each part is the same, the description is abbreviate | omitted. Note that the first liquid L1 filled in the first syringe 2 and the second liquid L2 filled in the second syringe 3 are liquids having different compositions (components).

  In the present invention, the first liquid L1 and the second liquid L2 are appropriately selected according to the use, purpose of use, case, and the like of the biological tissue adhesive applicator 1. For example, the first liquid L1 One of the second liquid L2 is preferably a liquid (solution or the like) containing gelatin, and the other is a liquid (solution or the like) that solidifies gelatin. As a liquid for solidifying gelatin, for example, a liquid containing glutaraldehyde can be exemplified.

  The first liquid L1 and the second liquid L2 in such a combination are altered, that is, gelled (solidified) when they are mixed. By gelling, for example, a mixture of the first liquid L1 and the second liquid L2 (hereinafter referred to as “mixed liquid”) can reliably remain in the applied biological tissue (target site). it can. Moreover, since the liquid mixture stays at the target site with certainty, the function as the biological tissue adhesive can be reliably exhibited at the target site.

The types and combinations of the first liquid L1 and the second liquid L2 are not limited to those described above, and may be a combination of a protein solution and a substance solution that serves as a protein cross-linking agent. For example, examples of the protein used include gelatin, collagen, and albumin. Examples of the crosslinking agent include formaldehyde, glutaraldehyde, and epoxy compounds.

  As shown in FIGS. 1 and 2, the applicator main body 4 loaded with the first syringe 2 filled with the first liquid L1 and the second syringe 3 filled with the second liquid L2 is The 1 syringe 2 and the 2nd syringe 3 are arranged in parallel and fixed. The applicator main body 4 includes a plate-like base portion 41 and a block-like holding portion 42 installed on the base portion 41.

  As shown in FIGS. 1 to 4, the holding unit 42 includes a holding unit main body 421 and a holding unit lid 422. The holding part main body 421 is fixed on the base part 41. The holding unit main body 421 and the holding unit lid 422 are connected by a hinge mechanism 423, and the holding unit lid 422 is attached to the holding unit main body 421 so as to be freely opened and closed. On the upper surface of the holding portion main body 421, a mounting recess 424 is formed in which the entire or part of the syringe outer cylinders 21 and 31 of the first syringe 2 and the second syringe 3 are respectively mounted (stored). In addition, the syringe outer cylinder 21 placed on the holder main body 421 is disposed on the surface of the holder lid 422 facing the holder main body 421 when the holder lid 422 is disposed on the holder main body 421. A coating recess 425 that covers the exposed surface of 31 is formed. As shown in FIGS. 1 and 2, the holding unit lid 422 is configured to be locked with a fixing unit 426 such as a butterfly bolt in a state where the holding unit lid 422 is arranged on the holding unit main body 421.

  Stopper walls 427 and 428 are provided at the tips of the mounting recesses 424 formed in the holding unit main body 421, and grooves 427a and 428a are formed in the stopper walls 427 and 428, respectively. When the first syringe 2 and the second syringe 3 are loaded, the mouth portion 211 of the first syringe 2 is inserted into the groove 427a, and the mouth portion 311 of the second syringe 3 is inserted into the groove 428a. Further, stopper walls 429 and 430 are also provided at the tips of the covering recesses 425 formed in the holding portion lid 422, and grooves 429a and 430a are formed in the stopper walls 429 and 430, respectively. When the holder lid 422 is placed on the holder main body 421, the groove 429a is disposed so as to cover the mouth 211 of the first syringe 2, and the groove 430a covers the mouth 311 of the second syringe 3. Are arranged as follows. The stopper walls 427 to 430 may be configured not to be formed at the tip of the mounting recess 424 or the tip of the covering recess 425.

  In addition, the holding portion main body 421 and the holding portion lid 422 are formed with insertion holes 43 that open in the side wall surfaces of the respective rear end portions and extend in a direction parallel to the mounting concave portion 424 and the covering concave portion 425. A heating body 44 such as a cartridge heater is inserted into the insertion hole 43. As the heating body 44, what can heat the holding | maintenance part 42, for example in the temperature range of 35 degreeC-50 degreeC can be used suitably. Further, a thermocouple 9 is embedded in a predetermined portion of the holding unit main body 421 so that the temperature of the holding unit main body 421 can be measured. In this embodiment, the thermocouple 9 is installed below each mounting recess 424 so that the temperature near each mounting recess 424 can be measured. In addition, since the thermocouple 9 is provided in order to contribute to temperature control of the liquids L1 and L2 stored in the first syringe 2 and the second syringe 3, as long as this purpose is achieved, Is not particularly limited.

  The heating body 44 is connected to a control device (not shown) disposed outside via a wiring cable 441. Similarly, the thermocouple 9 is also connected to a control device (not shown). The control device includes temperature control means, detects the temperature based on an output signal from the thermocouple 9, and stores the liquid L <b> 1 stored in the first syringe 2 and the second syringe 3 loaded in the holding unit main body 421. , L2 is configured to be able to automatically control the heat generation temperature of the heating body 44 so that the temperature of L2 becomes a predetermined temperature.

  The holding unit main body 421 and the holding unit lid 422 constituting the holding unit 42 are preferably formed from a metal material having excellent thermal conductivity, such as stainless steel or aluminum. Moreover, as long as it is a material excellent in heat conductivity, it is not limited to a metal material, The holding | maintenance part 42 can also be formed from various plastic materials.

  Moreover, the holding | maintenance part 42 is provided with the surrounding body 45 as shown in FIGS. The surrounding body 45 surrounds the first pipe line 213 and the second pipe line 313 connected to the mouth portions 211 and 311 of the syringe outer cylinders 21 and 31 of the first syringe 2 and the second syringe 3, respectively. It is a member. The surrounding body 45 includes a surrounding lower portion 451 connected to the holding portion main body 421 and an surrounding upper portion 452 connected to the holding portion lid 422, and the holding portion lid 422 is disposed on the holding portion main body 421. In this state, as shown in the cross-sectional view of FIG. 6, the surrounding lower portion 451 and the surrounding upper portion 452 are configured to surround the first conduit 213 and the second conduit 313. An opening 453 is formed at the distal end of the surrounding body 45, and a covering body 46 that integrally covers both the distal ends of the first pipe 213 and the second pipe 313 is formed in the opening 453. Has been placed.

  The surrounding body 45 and the covering body 46 are preferably formed of a metal material having excellent thermal conductivity, such as stainless steel or aluminum, as with the holding portion 42. Moreover, as long as it is a material excellent in heat conductivity, it is not limited to a metal material, The surrounding body 45 and the covering body 46 can also be formed from various plastic materials.

  A heat transfer plate 47 is provided inside the enclosure 45 and between the first pipe 213 and the second pipe 313. The heat transfer plate 47 is made of a metal material having excellent thermal conductivity, such as stainless steel or aluminum, or a plastic material having excellent thermal conductivity.

  The operating means 5 is means for pressing the pushers 23 and 33 of the first syringe 2 and the second syringe 3 loaded in the holding portion 42 in the distal direction (the direction of arrow C in FIGS. 1 and 2). The holding part 42 is connected to the base part 41. The operation means 5 includes a pressing tool 51 and a gripping tool 52.

  The pressing tool 51 has a plate-like body 512 provided on one surface with a plurality of moving claws 511 formed in a saw-tooth shape to be an engaging portion with a moving piece 524 described later, and standing on an end portion of the plate-like body 512. The pressing part 513 is provided. The pressing tool 51 is installed to be movable with respect to the applicator main body 4 in the longitudinal direction (left and right direction in FIG. 2). The plate-like body 512 in the pressing tool 51 is disposed between the applicator main body 4 and the gripping tool 52. In addition, depending on the kind of the 1st syringe 2 and the 2nd syringe 3 hold | maintained at the holding | maintenance part 42, the pushing part 23 (33) with which the press part 513 in the press tool 51 and the 1st syringe 2 and / or the 2nd syringe 3 are provided. In some cases, a gap may be formed between the flange 233 and the flange 233 (333). In such a case, a spacer 514 may be provided in the gap as shown in FIGS.

  The gripping tool 52 is for moving the pressing tool 51 so that the pressing portion 513 presses the pushers 23 and 33 of the first syringe 2 and the second syringe 3, and as shown in FIG. 521, a trigger portion 522, and a trigger spring 523 that regulates the relative positions of the handle portion 521 and the trigger portion 522 and enables a trigger operation. A moving piece 524 that engages with the moving claw 511 and ratchet is disposed near the tip of the trigger portion 522. By performing an operation (triggering operation) for pulling the trigger portion 522 against the elasticity of the trigger spring 523, the moving piece 524 disposed near the tip of the trigger portion 522 rotates around the fulcrum 525. The plate 512 of the pressing tool 51 can be moved until it is caught by the moving claw 511 with which the moving piece 524 is engaged and the engaged state is lost.

  When the grip on the trigger portion 522 is loosened, the trigger portion 522 is returned to the original position by the elastic restoring force of the trigger spring 523, and the moving piece 524 is also returned to the original position in accordance with this, but the moving claw 511 moves. Since the top 524 is ratchet-engaged, the moving top 524 does not press the moving claw 511 and return the plate-like body 512 to the original position when the trigger portion 522 returns to the original position.

  By repeating the trigger operation as described above, the pressing portion 513 provided at the end of the plate-like body 512 can press the pushers 23 and 33 of the first syringe 2 and the second syringe 3, It becomes possible to discharge the first liquid L1 and the second liquid L2 accommodated in the first syringe 2 and the second syringe 3. In addition, when loading the first syringe 2 and the second syringe 3 into the applicator main body and starting the discharge of the first liquid L1 and the second liquid L2, depending on the syringe size, the liquids L1 and L2 may be There may be a deviation in the timing at which the leading ends of the first pipe 213 and the second pipe 313 are reached. When such a situation occurs, the quality of the biological tissue adhesive produced by mixing may be deteriorated. However, such a situation is connected to the mouth portions 211 and 311 of the first syringe 2 and the second syringe 3. This can be avoided by adjusting the lengths and diameters of the first pipe 213 and the second pipe 313.

  As described above, the biological tissue adhesive applicator 1 according to the present invention is configured to include heating means (heating body 44) for heating the holding portion 42 in which the first syringe 2 and the second syringe 3 are held. Therefore, the liquids L1 and L2 stored in the first syringe 2 and the second syringe 3 can be effectively prevented from solidifying. In particular, when the liquid stored in the first syringe 2 (or the second syringe 3) is a liquid containing gelatin, the liquid gels at room temperature, but the gel is heated by heating means. It is possible to change the state of the converted liquid into a solution having a low viscosity, preventing clogging, and applying the solution to the affected area of the patient.

  Moreover, the holding | maintenance part 42 is the circumference | surroundings of the 1st pipe line 213 and the 2nd pipe line 313 respectively connected to the mouth parts 211 and 311 which each syringe outer cylinder 21 and 31 of the 1st syringe 2 and the 2nd syringe 3 has. A surrounding body 45 is provided. Since the surrounding body 45 is formed of a material having excellent thermal conductivity, the heat of the holding portion 42 heated by the heating means is efficiently transmitted to the surrounding body 45. The heat transmitted to the enclosure 45 is radiated toward the first pipeline 213 and the second pipeline 313 disposed inside the enclosure 45, and therefore the first pipeline 213 and the clogging due to solidification are likely to occur. The liquids L1 and L2 inside the second pipe 313 can be effectively heated, and clogging due to solidification of the liquid can be prevented.

  In addition, since a heat transfer plate 47 formed of a material having excellent thermal conductivity is provided inside the enclosure 45 and between the first pipe 213 and the second pipe 313, the holding portion The heat generated by the heating means (heating body 44) is transmitted to the heat transfer plate 47 through the surrounding body 45 connected to 42 and the holding portion 42. Since the heat transmitted to the heat transfer plate 47 is dissipated, the first conduit 213 and the second conduit 313 disposed in the vicinity of the heat transfer plate 47 can be efficiently heated, and the first conduit 213 and It is possible to more effectively prevent the liquids L1 and L2 inside the second pipe 313 from solidifying and clogging.

  In addition, the covering body 46 is provided with a covering body 46 that integrally covers both the first pipe line 213 and the second pipe line 313 disposed near the opening 453 at the front end of the surrounding body 45. Also, since the cover 46 is formed of a material having excellent thermal conductivity, the cover 46 efficiently receives the heat radiated from the surrounding body 45 and the heat radiated by the heat transfer plate 47. The covering 46 dissipates the received heat to the liquids L1 and L2 in both ends of the first pipe 213 and the second pipe 313, so that the first pipe 213 and the second pipe 313 It becomes possible to efficiently heat the liquids L1 and L2 in both tip portions. Since both the front ends of the first pipe 213 and the second pipe 313 are arranged in the vicinity of the opening 453 at the front end of the surrounding body 45, they are most affected by the outside air and solidify due to the low temperature, and are clogged. Although it is easy to generate, it is possible to prevent clogging at the portion by effective heating by the covering 46.

  The holding unit 42 includes a holding unit main body 421 on which the syringe outer cylinders 21 and 31 of the first syringe 2 and the second syringe 3 are placed, and a holding unit attached to the holding unit main body 421 so as to be freely opened and closed. Since the cover 422 is provided, the first syringe 2 and the second syringe 3 can be easily installed and removed. In addition, since the heating body 44 is installed inside the holding unit main body 421 and the holding unit lid 422, the holding unit main body 421 and the holding unit lid 422 can be reliably and efficiently heated. As a result, the liquids L1 and L2 stored in the first syringe 2 and the second syringe 3 can be effectively prevented from solidifying. Further, by heating the solidified liquids L1 and L2, the state can be changed to a solution having a low viscosity, and clogging can be prevented and applied to the affected area of the patient.

  Moreover, the biological tissue adhesive applicator 1 according to the present invention includes the thermocouple 9 and is configured to be able to measure the temperature in the vicinity of the mounting recess 424. With such a configuration, the heat generation temperature of the heating body 44 is controlled based on the measured temperature, and the temperatures of the liquids L1 and L2 stored in the first syringe 2 and the second syringe 3 become the desired temperatures. In addition, by changing the heat generation temperature of the heating body 44, it is possible to adjust the gelation rate of the mixed liquid obtained by mixing the liquids L1 and L2.

  As mentioned above, although embodiment of the biological tissue adhesive applicator 1 which concerns on this invention was described, the specific structure of the biological tissue adhesive applicator 1 is not limited to the said embodiment. For example, in the above-described embodiment, a configuration is adopted in which the insertion hole 43 is formed in both the holding unit main body 421 and the holding unit lid 422, and the heating body 44 is installed in the insertion hole 43. An insertion hole 43 may be formed in either the main body 421 or the holding portion lid 422, and the heating body 44 may be installed in the insertion hole 43.

  Moreover, in the said embodiment, although comprised so that the heating body 44 may be installed in the insertion hole 43 formed in the holding | maintenance part main body 421 and the holding | maintenance part cover body 422, for example, schematic structure sectional drawing of FIG. As shown in FIG. 4, a sheet-like heating body 44 such as a sheet heater (planar heating element) is installed on the lower surface of the holding portion main body 421 and / or the upper surface of the holding portion lid 422. Also good. In addition, when employ | adopting such a structure, it is preferable to cover the exposed surface of the sheet-like heating body 44 with the heat insulating cover 6 from a viewpoint of safety.

  In the above-described embodiment, the holding portion 42 includes the holding portion main body 421 and the holding portion lid 422, and the holding portion lid 422 is configured to be openable and closable with respect to the holding portion main body 421. For example, the holding unit lid 422 may be omitted, and the holding unit 42 may be configured by only the holding unit main body 421. Even in such a configuration, the liquid L1 and L2 stored in the first syringe 2 and the second syringe 3 loaded in the holding unit main body 421 by the action of the heating body 44 installed in the holding unit main body 421. It is possible to heat the liquids L1 and L2 in the first conduit 213 and the second conduit 313 by heat transmitted from the holding portion main body 421 to the surrounding lower portion 451.

  In the above embodiment, the first syringe 2 and the second syringe 2 are overlapped with the first syringe 2 and the second syringe 3 that are placed in the placement recess 424 of the holder main body 421 by overlapping the holder lid 422. Although it is comprised so that the syringe 3 may be fixed to the holding | maintenance part 42, as shown in sectional drawing of FIG. 8 instead of such a structure, the 1st syringe 2 and the 2nd syringe are added to the block-shaped holding | maintenance part 42. 3 are formed, the first syringe 2 and the second syringe 3 are inserted into the holes 71 and 72, and the first syringe 2 and the second syringe 3 are held by the holding portion 42. You may comprise so that it may fix to.

  Moreover, in the said embodiment, the operation means 5 presses each pusher 23 and 33 which the 1st syringe 2 and the 2nd syringe 3 have by the trigger operation of the gun-type gripping tool 52 and the said gripping tool 52. However, the present invention is not particularly limited to such a configuration. For example, the gun-type gripping tool 52 is omitted, and the pushers 23 in the first syringe 2 and the second syringe 3 are provided. The operating means 5 may be constituted by a connecting tool that connects and fixes the flanges 233 and 333 of 33. When such a configuration is employed, the first liquid L1 and the second liquid L2 accommodated in the first syringe 2 and the second syringe 3 can be discharged by pressing the connector. .

DESCRIPTION OF SYMBOLS 1 Biological tissue adhesive applicator 2 1st syringe 21 Syringe outer cylinder 211 Mouth part 22 Gasket 23 Pusher 3 2nd syringe 31 Syringe outer cylinder 311 Mouth part 32 Gasket 33 Pusher 44 Heating body (heating means)

Claims (4)

Each includes a syringe outer cylinder having a mouth portion protruding from the tip, a gasket inserted into the syringe outer cylinder, and a pusher for moving the gasket along the longitudinal direction of the syringe outer cylinder. A biological tissue adhesive applicator comprising a first syringe and a second syringe, wherein a space formed by each syringe outer cylinder and each gasket is filled with liquids for biological tissue adhesives having different liquid compositions. And
And heating means capable of heating the first syringe and the second syringe,
A holding part that is formed from a thermally conductive material and holds at least a part of each syringe outer cylinder of the first syringe and the second syringe;
A first conduit and a second conduit connected to each of the mouths of each syringe outer cylinder of the first syringe and the second syringe;
The holding unit is configured to be openable and closable with respect to the holding unit main body in which a mounting recess is formed in which at least a part of each syringe outer cylinder of the first syringe and the second syringe is mounted. And a holding portion lid formed with a covering recess that covers the exposed surface of each syringe outer cylinder mounted and mounted,
The heating unit is installed in at least one of the holding unit main body and the holding unit lid, and the heating unit heats at least one of the holding unit main body and the holding unit lid. Indirectly heating the first syringe and the second syringe;
The holding portion surrounds a periphery of the first conduit and the second conduit, provided with a surrounding body formed of a thermally conductive material,
The surrounding body is connected to the holding portion, and is heated by heat transfer from the holding portion main body or the holding portion lid body, thereby indirectly connecting the first pipe line and the second pipe line. A tissue adhesive applicator for heating .   The biological tissue adhesive applicator according to claim 1, wherein the enclosure includes a heat transfer plate disposed between the first duct and the second duct. A covering body that integrally covers both ends of the first pipe line and the second pipe line;
The biological tissue adhesive applicator according to claim 1, wherein the covering is formed of a heat conductive material. The biological tissue adhesive according to any one of claims 1 to 3, wherein one of the liquids for biological tissue adhesives having different liquid compositions is a liquid containing gelatin and the other is a liquid for solidifying gelatin. Agent applicator.