JP5699007B2 - Gas generating material and micro pump - Google Patents

Description

  The present invention relates to a gas generating material and a micropump including the same.

  In recent years, analyzers using microfluidic devices have come to be used as analyzers that are small and have excellent portability. In the analysis apparatus using the microfluidic device, the sample can be fed, diluted, analyzed, and the like in the microchannel.

  For example, in Patent Document 1 below, a pump function is imparted to a microfluidic device by providing a gas generation layer so as to cover the main surface of the substrate on which a microchannel opening on one main surface is formed. It is described to do. Patent Document 1 exemplifies various azo compounds and azide compounds as gas generating agents to be contained in the gas generating layer.

JP 2010-107515 A

  However, the azo compound and the azide compound described in Patent Document 1 have a problem that the amount of gas generated per unit time is not sufficiently large and the gas generation period is short.

  The present invention has been made in view of such a point, and an object thereof is to provide a gas generating material having a long gas generation period and a large amount of gas generation per unit time.

  The gas generating material according to the present invention includes a gas generating agent having a sulfonyl azide group, and at least one of a photosensitizer and a binder.

  The gas generating agent is preferably represented by the following formula (1).

(However, each of R _{1 to} R ₅ is an alkyl group having 1 to 12 carbon atoms.)
The gas generating agent is preferably represented by the following formula (2).

  It is preferable that the content rate of the gas generating agent in a gas generating material exists in the range of 45 mass%-99.99 mass%.

  The micropump according to the present invention includes the gas generating material according to the present invention and a base material on which a microchannel is formed. The gas generating material is arranged so that the gas generated in the gas generating material is supplied to the microchannel.

  According to the present invention, it is possible to provide a gas generating material having a long gas generation period and a large amount of gas generation per unit time.

1 is a schematic cross-sectional view of a micropump according to a first embodiment. It is a schematic sectional drawing of the micropump which concerns on 2nd Embodiment. It is a graph showing the flow rate of the micropump of Example 1 and Comparative Examples 1-3.

  Hereinafter, an example of the preferable form which implemented this invention is demonstrated. However, the following embodiment is merely an example. The present invention is not limited to the following embodiments.

  Moreover, in each drawing referred in embodiment etc., the member which has a substantially the same function shall be referred with the same code | symbol. The drawings referred to in the embodiments and the like are schematically described, and the ratio of the dimensions of the objects drawn in the drawings may be different from the ratio of the dimensions of the actual objects. The dimensional ratio of the object may be different between the drawings. The specific dimensional ratio of the object should be determined in consideration of the following description.

(First embodiment)
FIG. 1 is a schematic cross-sectional view of the micropump according to the first embodiment.

  As shown in FIG. 1, the micropump 1 includes a plate-like base material 10. The base material 10 can be formed of, for example, resin, glass, ceramic, or the like. Examples of the resin preferably used for forming the base material 10 include organic siloxane compounds, polymethacrylate resins, and cyclic polyolefins. Specific examples of the organic siloxane compound include polydimethylsiloxane (PDMS) and polymethylhydrogen siloxane.

  The base 10 is formed with a microchannel 10b that is open to the main surface 10a.

  Here, the “micro flow channel” refers to a flow channel formed in a shape and dimension in which a so-called micro effect is expressed in the liquid flowing through the micro flow channel. Specifically, the term “microchannel” means that the liquid flowing through a microchannel is strongly affected by surface tension and capillary action, and has a different shape from that of a liquid flowing through a normal channel. It refers to the flow path that is formed.

  A film-like gas generating material 11a is stuck on the main surface 10a. The opening of the microchannel 10b is covered with the gas generating material 11a. For this reason, the gas generated from the gas generating material 11a when an external stimulus such as light or heat is applied to the gas generating material 11a is guided to the micro flow path 10b.

  Although the thickness of the gas generating material 11a is not specifically limited, For example, it can be set as about 10 micrometers-200 micrometers.

  The gas generating material 11 a is covered with a gas barrier layer 12. The gas barrier layer 12 suppresses the gas generated in the gas generating material 11a from flowing out to the side opposite to the main surface 10a, and is efficiently supplied to the microchannel 10b. For this reason, it is preferable that the gas barrier layer 12 has a low permeability of the gas generated in the gas generating material 11a.

  The gas barrier layer 12 can be formed of, for example, polyacryl, polyolefin, polycarbonate, vinyl chloride resin, ABS resin, polyethylene terephthalate (PET) resin, nylon resin, urethane resin, polyimide resin, and glass.

  In addition, although the thickness of the gas barrier layer 12 changes with materials etc. of the gas barrier layer 12, it can be set as about 25 micrometers-100 micrometers, for example.

  The gas generating material 11a includes a gas generating agent that generates gas when an external stimulus such as heat or light is applied. In the present embodiment, the gas generating agent is a photoresponsive gas generating agent that generates gas when irradiated with light. The gas generating material 11a further includes at least one of a binder resin and a photosensitizer in addition to the gas generating agent. As the binder resin, for example, an acrylic resin or a glycidyl azide polymer is preferably used. Binder resin should just be contained in the range which can hold | maintain the shape of a gas generating material. The binder resin is preferably contained in the range of 0.01 to 800 parts by weight, for example, in the range of 10 to 400 parts by weight with respect to 100 parts by weight of the gas generating agent. It is more preferable that it is contained in the range of 40 parts by weight to 200 parts by weight.

  As the photosensitizer, benzophenone, diethylthioxanthone, anthraquinone, benzoin, acridine derivatives and the like are preferably used. The photosensitizer is preferably contained in the range of 0.01 to 50 parts by weight and contained in the range of 0.2 to 20 parts by weight with respect to 100 parts by weight of the gas generating agent. More preferably, it is contained in the range of 1 to 10 parts by weight.

  In the present embodiment, the gas generating agent has a sulfonyl azide group. For this reason, the gas generating agent of this embodiment has a large amount of gas generation per unit time and a long gas generation period. Therefore, by using the gas generating material 11a, the micropump 1 having a high output and a long driving time can be realized.

  The reason why the amount of gas generated per unit time of the gas generating agent having a sulfonyl azide group is large and the gas generation period is long is not clear, but because the sulfonyl group exhibits high electron withdrawing property by ultraviolet irradiation, This is probably because the azide group decomposes.

  Among the gas generating agents having a sulfonyl azide group, those having an aromatic ring are preferably used. Specifically, a gas generating agent represented by the following formula (1) is more preferably used.

(However, each of R _{1 to} R ₅ is a hydrogen atom, a halogen atom, an amino group, a phenyl group, a linear or branched alkyl group having 1 to 12 carbon atoms, or a linear or branched alkyl group having 2 to 12 carbon atoms. An alkenyl group having 3 to 12 carbon atoms, a linear or branched alkynyl group having 3 to 12 carbon atoms, an aralkyl group having 7 to 12 carbon atoms, an alicyclic group having 5 to 12 carbon atoms, or an alkoxy group having 1 to 12 carbon atoms. )

  Examples of the alkyl group include methyl group, ethyl group, propyl group, isopropyl group, n-butyl group, isobutyl group, sec-butyl group, tert-butyl group, n-pentyl group, isopentyl group, sec-pentyl group, tert- Pentyl group, n-hexyl group, isohexyl group, sec-hexyl group, tert-hexyl group, n-heptyl group, isoheptyl group, sec-heptyl group, tert-heptyl group, n-octyl group, isooctyl group, sec-octyl Group, tert-octyl group, dimethylhexyl group, dimethylbutyl group, ethylbutyl group, n-nonyl group, isononyl group, sec-nonyl group, tert-nonyl group, n-decyl group, isodecyl group, sec-decyl group, tert -Decyl group, n-dodecyl group, isododecyl group, sec-dodecyl group Such as tert- dodecyl group can be mentioned.

  Examples of the linear or branched alkenyl group having 2 to 12 carbon atoms include ethynyl group, 1-propynyl group, 1-butynyl group, 1-pentynyl group, 3-pentynyl group, 1-hexynyl group and 2-ethyl-2 -Butynyl group, 2-octynyl group, (4-ethynyl) -5-hexynyl group, 2-decynyl group, dodecenyl group and the like can be mentioned.

  Examples of the linear or branched alkynyl group having 3 to 12 carbon atoms include propynyl group, butenyl group, cyclohexynyl group, octiniyl group, and the like.

  Aralkyl groups having 7 to 12 carbon atoms (for example, benzyl group, phenethyl group, 3-phenylpropyl group, naphthylmethyl group, 2-naphthylethyl group, etc.) can be mentioned.

  Examples of the alicyclic group having 5 to 12 carbon atoms include a cyclopentyl group, a cyclohexyl group, a cyclooctyl group, a tricyclodecyl group, a bicyclooctyl group, and a tricyclododecyl group.

  Examples of the alkoxy group include a methoxy group, an ethoxy group, an n-propoxy group, an isopropyloxy group, an n-butoxy group, a pentyloxy group, a hexyloxy group, an octyloxy group, a decyloxy group, and a dodecyloxy group.

Among _them, each of R 1 to R _5, carbon atoms is preferred from 1 to 12 alkyl group.

  Furthermore, a gas generating agent represented by the following formula (2) is more preferably used.

  In addition, although the content rate of the gas generating agent in the gas generating material 11a is not specifically limited, It is preferable that it is 45 mass%-99.99 mass%, and it is more preferable that it is 45 mass%-99 mass%. If the content of the gas generating agent in the gas generating material 11a is too low, the amount of gas generated may be too small. If the content of the gas generating agent in the gas generating material 11a is too high, the rigidity of the gas generating material 11a becomes too low, and the amount of gas supplied to the micro flow path 10b may be reduced.

  Hereinafter, an example of the preferable form which implemented this invention is demonstrated. In the following description, members having substantially the same functions as those of the first embodiment are referred to by the same reference numerals, and description thereof is omitted.

(Second Embodiment)
FIG. 2 is a schematic cross-sectional view of the micropump according to the second embodiment.

  The micropump 2 according to the present embodiment is different from the micropump 1 according to the first embodiment in the shape of the gas generating material and the shape of the base material 10.

  In the present embodiment, the micro flow path 10 b is connected to a pump chamber 10 c formed in the base material 10. The gas generating material 11b is formed in a block shape and is arranged in the pump chamber 10c.

  Also in the micropump 2 according to the present embodiment, as in the micropump 1, a high output and a long drive time can be realized.

  Hereinafter, the present invention will be described in more detail on the basis of specific examples. However, the present invention is not limited to the following examples, and may be appropriately modified and implemented without departing from the scope of the present invention. Is possible.

Example 1
An acrylic copolymer (weight average molecular weight 700,000) of 96.5 parts by weight of 2-ethylhexyl acrylate, 3 parts by weight of acrylic acid, and 0.5 parts by weight of 2-hydroxyethyl acrylate was produced. Next, 100 parts by weight of the acrylic copolymer, 200 parts by weight of ethyl acetate as a solvent, 3 parts by weight of an isocyanate compound (trade name Coronate L45, manufactured by Nippon Polyurethane Co., Ltd.) as a crosslinking agent, and the above formula ( 2) 100 parts by weight of 4-dodecylbenzenesulfonyl azide (Toyobo, DBSN) represented by 2) and 3.5 parts by weight of diethylthioxanthone (Ciba Specialty Chemicals, DETX-S) as a photosensitizer are mixed. Then, it was processed into a film to obtain a film-like gas generating material. Using this gas generating material, a micropump having a configuration substantially similar to the micropump 1 of the first embodiment was produced.

  The cross-sectional shape of the microchannel was a 0.5 mm square shape. The length of the microchannel 11 was 800 mm. The tip of the microchannel was open to the atmosphere. The gas generating material was a 1 cm × 1 cm size film having a thickness of 50 μm. The weight of the gas generating material was about 0.006 g.

(Comparative Example 1)
A gas generating film was prepared in the same manner as in Example 1 except that 100 parts by weight of diphenyl phosphate azide (manufactured by Toyobo Co., Ltd., DPPA) was used instead of 100 parts by weight of 4-dodecylbenzenesulfonyl azide to prepare a micropump. did.

(Comparative Example 2)
A gas generating film was prepared in the same manner as in Example 1 except that 100 parts by weight of azodicarbonamide (manufactured by Sankyo Kasei Co., Ltd., Celmark C-2) was used instead of 100 parts by weight of 4-dodecylbenzenesulfonyl azide, A micropump was produced.

(Comparative Example 3)
The above implementation was performed except that 100 parts by weight of 2,2′-azobis (N-butyl-2-methylpropionamide) (manufactured by Wako Pure Chemical Industries, Ltd., VAM110) was used instead of 100 parts by weight of 4-dodecylbenzenesulfonyl azide. A gas generating film was produced in the same manner as in Example 1 to produce a micropump.

(Evaluation)
1 μL of water was injected into the microchannel of the micropump prepared in each of Example 1 and Comparative Examples 1 to 3. Then, ultraviolet rays with a wavelength of 375 nm were irradiated using an LED with an output of 14 mW, and the movement distance of the water droplet was measured every 10 seconds. The results are shown in FIG. Moreover, the movement speed of the water droplet was computed from the result. Further, from the calculated movement speed of the water droplets, a time for maintaining a flow rate of 10 μl / min or more (hereinafter referred to as “gas generation period”) is used. ) Was calculated. The results are shown in Table 1 below.

  The flow rate evaluation and gas generation period evaluation shown in Table 1 below are based on the following criteria.

Flow rate evaluation criteria: ◎: 10 μl / min or more, ○: 5 μl / min or more and less than 10 μl / min, Δ: 1 μl / min or more and less than 5 μl / min, ×: less than 1 μl / min Gas generation period evaluation criteria: ◎: 2 minutes or more , ○: 1 minute or more and less than 2 minutes 2 μl / minute or more, Δ: 30 seconds or more and less than 1 minute, ×: less than 30 seconds

DESCRIPTION OF SYMBOLS 1, 2 ... Micro pump 10 ... Base material 10a ... Main surface 10b ... Micro flow path 10c ... Pump chamber 11 ... Micro flow path 11a, 11b ... Gas generating material 12 ... Gas barrier layer

Claims (3)

A gas generating agent represented by the following formula (2) ;
At least one of a photosensitizer and a binder;
Including gas generating material.

The gas generating material according to claim 1, wherein the content of the gas generating agent is in a range of 45 mass% to 99.99 mass%. The gas generating material according to claim 1 or 2 ,
A substrate on which a microchannel is formed;
With
The gas generating material is a micropump arranged such that gas generated in the gas generating material is supplied to the micro flow path.

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