JP5660817B2 - Internal solution containing sumatriptan succinate - Google Patents
Internal solution containing sumatriptan succinate Download PDFInfo
- Publication number
- JP5660817B2 JP5660817B2 JP2010163568A JP2010163568A JP5660817B2 JP 5660817 B2 JP5660817 B2 JP 5660817B2 JP 2010163568 A JP2010163568 A JP 2010163568A JP 2010163568 A JP2010163568 A JP 2010163568A JP 5660817 B2 JP5660817 B2 JP 5660817B2
- Authority
- JP
- Japan
- Prior art keywords
- acid
- sweetener
- internal
- liquid
- sumatriptan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 title claims description 100
- 229960000658 sumatriptan succinate Drugs 0.000 title claims description 53
- 235000003599 food sweetener Nutrition 0.000 claims description 109
- 239000003765 sweetening agent Substances 0.000 claims description 109
- 239000007788 liquid Substances 0.000 claims description 65
- 238000002360 preparation method Methods 0.000 claims description 65
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 63
- -1 alkali metal salt Chemical class 0.000 claims description 40
- 150000007524 organic acids Chemical class 0.000 claims description 39
- 229930006000 Sucrose Natural products 0.000 claims description 28
- 239000005720 sucrose Substances 0.000 claims description 28
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 27
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 235000015165 citric acid Nutrition 0.000 claims description 21
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims description 18
- 239000004376 Sucralose Substances 0.000 claims description 18
- 235000010358 acesulfame potassium Nutrition 0.000 claims description 18
- 229960004998 acesulfame potassium Drugs 0.000 claims description 18
- 239000000619 acesulfame-K Substances 0.000 claims description 18
- 235000019408 sucralose Nutrition 0.000 claims description 18
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 18
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 17
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 17
- 239000000811 xylitol Substances 0.000 claims description 17
- 235000010447 xylitol Nutrition 0.000 claims description 17
- 229960002675 xylitol Drugs 0.000 claims description 17
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 17
- 229960005070 ascorbic acid Drugs 0.000 claims description 14
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- 239000011668 ascorbic acid Substances 0.000 claims description 12
- 229910052783 alkali metal Inorganic materials 0.000 claims description 11
- 239000000654 additive Substances 0.000 claims description 10
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 8
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 8
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 8
- 235000011090 malic acid Nutrition 0.000 claims description 8
- 239000001630 malic acid Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 239000001509 sodium citrate Substances 0.000 claims description 8
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical group O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 8
- 235000002906 tartaric acid Nutrition 0.000 claims description 8
- 239000011975 tartaric acid Substances 0.000 claims description 8
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 7
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 6
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 6
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 6
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 5
- 230000000996 additive effect Effects 0.000 claims description 4
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 3
- 239000001361 adipic acid Substances 0.000 claims description 3
- 235000011037 adipic acid Nutrition 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
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- 239000000174 gluconic acid Substances 0.000 claims description 3
- 235000012208 gluconic acid Nutrition 0.000 claims description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
- 239000000243 solution Substances 0.000 description 56
- 229960003708 sumatriptan Drugs 0.000 description 46
- 230000000052 comparative effect Effects 0.000 description 19
- 238000003860 storage Methods 0.000 description 19
- 235000019658 bitter taste Nutrition 0.000 description 14
- 239000000126 substance Substances 0.000 description 13
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- 239000000203 mixture Substances 0.000 description 12
- 150000005846 sugar alcohols Chemical class 0.000 description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 11
- 239000001301 oxygen Substances 0.000 description 11
- 229910052760 oxygen Inorganic materials 0.000 description 11
- 238000013094 purity test Methods 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 238000009472 formulation Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 239000008213 purified water Substances 0.000 description 8
- 239000012488 sample solution Substances 0.000 description 8
- 235000000346 sugar Nutrition 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 7
- 229910001873 dinitrogen Inorganic materials 0.000 description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 7
- 239000011261 inert gas Substances 0.000 description 7
- 235000011083 sodium citrates Nutrition 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 230000037406 food intake Effects 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 150000003627 tricarboxylic acid derivatives Chemical class 0.000 description 6
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 5
- 206010013911 Dysgeusia Diseases 0.000 description 5
- 208000019695 Migraine disease Diseases 0.000 description 5
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 5
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- 238000004519 manufacturing process Methods 0.000 description 5
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- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 4
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Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
本発明は、長期保存安定性に優れ、かつ服用しやすいスマトリプタンコハク酸塩含有内用液剤に関する。 The present invention relates to a sumatriptan succinate-containing internal preparation that is excellent in long-term storage stability and easy to take.
スマトリプタン（Sumatriptan、化学名：３−［２−（ジメチルアミノ）エチル］−Ｎ−メチルインドール−５−メタンスルホンアミド）は、５−ＨＴ１受容体、特に５−ＨＴ１Ｂ及び５−ＨＴ１Ｄ受容体に作用して、頭痛発作時に過度に拡張した頭蓋内外の血管を収縮させることにより、片頭痛を改善すると考えられている。また、スマトリプタンは三叉神経に作用して、神経末端からのＣＧＲＰ（calcitonin gene-related peptide）など起炎性ペプチドの放出を抑制することも、片頭痛の緩解に寄与していると考えられている。従って、スマトリプタンを含有する製剤は、優れた片頭痛薬として知られている。 Sumatriptan (chemical name: 3- [2- (dimethylamino) ethyl] -N-methylindole-5-methanesulfonamide) is a 5-HT1 receptor, in particular 5-HT1B and 5-HT1D receptors. It is believed to improve migraine by acting and constricting blood vessels inside and outside of the skull that have dilated excessively during headache attacks. Sumatriptan also acts on the trigeminal nerve and suppresses the release of inflammatory peptides such as CGRP (calcitonin gene-related peptide) from nerve endings, which is thought to contribute to the mitigation of migraine. Yes. Therefore, formulations containing sumatriptan are known as excellent migraine drugs.
スマトリプタン含有製剤としては、現在、錠剤、注射剤及び点鼻剤が医薬品として上市されている。しかしながら、錠剤は服用するのに水等を必要とするため、特に外出時等には、片頭痛の頭痛発現時に服用するための剤形として患者の利便性が低く、かつ、高齢者等の嚥下が困難な患者にとっては、ＱＯＬ（Quality of Life）上も好ましくない。また、点鼻剤もその投与が患者に苦痛を与えることがあることから、敬遠されることが多々ある。さらに注射剤は、病院等の特定の場所でなければ投与できないなど不便である。したがって、これらの現状から医療現場では、スマトリプタンを有効成分として含有する内用液剤が望まれていた。
一方、スマトリプタン又はその薬理学的に許容される塩、例えばスマトリプタンコハク酸塩は、通常の条件下では酸、塩基、酸化及び紫外線照射には安定であり、９０℃に加熱したときは酸性、塩基性及び酸化性条件下で分解することが知られている（非特許文献１）。
本発明者らの検討によれば、スマトリプタンコハク酸塩の内用液剤の場合、上記の９０℃加熱より緩和な条件であっても、酸素濃度やｐＨ値により、スマトリプタンコハク酸塩の分解及び内用液剤の変色が起こる。また、スマトリプタンコハク酸塩は、苦味を有することが知られている。スマトリプタンコハク酸塩を含む内用液剤の開発にはこれらの全ての問題を解決することが求められる。
スマトリプタンコハク酸塩を含む内用液剤は、例えば特許文献１等により公知である。特許文献１には、上記のスマトリプタンコハク酸塩を活性成分とする内用液剤として、例えば、シロップ剤又は懸濁液が開示されている。該シロップ剤は、ヒドロキシメチルセルロース、水及び緩衝液を含むとされているが、具体的な緩衝液の開示はなく、また、甘味剤等も含まれないことから、到底上記問題点が解決されている製剤とは言い難い。また、懸濁液は、モノステアリン酸アルミニウム、甘味剤及び分留されたココヤシ油を含み、水を含まない製剤であり、内用剤としての服用性等の問題が解決されているか疑問である。
Currently, tablets, injections and nasal drops are commercially available as pharmaceuticals for sumatriptan-containing preparations. However, since tablets require water, etc., especially when going out, it is not convenient for patients as a dosage form for taking migraine headache, and swallowing by the elderly This is not preferable for patients who have difficulty in QOL (Quality of Life). Also, nasal drops are often avoided because their administration can be painful to the patient. Furthermore, an injection is inconvenient because it can only be administered at a specific location such as a hospital. Therefore, from the present situation, in the medical field, an internal solution containing sumatriptan as an active ingredient has been desired.
On the other hand, sumatriptan or a pharmacologically acceptable salt thereof, such as sumatriptan succinate, is stable to acid, base, oxidation and ultraviolet irradiation under normal conditions, and acidic when heated to 90 ° C. It is known to decompose under basic and oxidizing conditions (Non-patent Document 1).
According to the study by the present inventors, in the case of a liquid for internal use of sumatriptan succinate, the decomposition of sumatriptan succinate depends on the oxygen concentration and pH value even under the conditions milder than the above heating at 90 ° C. And discoloration of the liquid for internal use occurs. Sumatriptan succinate is also known to have a bitter taste. The development of an internal solution containing sumatriptan succinate is required to solve all these problems.
An internal solution containing sumatriptan succinate is known, for example, from Patent Document 1. Patent Document 1 discloses, for example, a syrup or suspension as an internal solution containing the above sumatriptan succinate as an active ingredient. The syrup preparation is said to contain hydroxymethylcellulose, water and a buffer solution, but there is no disclosure of a specific buffer solution, and no sweetener etc. are contained, so that the above problems have been solved. It is hard to say that it is a formulation. In addition, the suspension contains aluminum monostearate, sweetener and fractionated coconut oil and does not contain water, and it is questionable whether problems such as ingestion as an internal preparation have been solved. .
現在市販されている経口剤として、スマトリプタンコハク酸塩を含む錠剤があり、該錠剤においては、フィルムコートにより、苦味防止を図っている。スマトリプタンを含むその他の市販製剤としては、点鼻液及び注射液があるが、内用液剤の市販品はない。
点鼻液では、リン酸二水素カリウム、無水リン酸一水素ナトリウム、硫酸及び水酸化ナトリウムを含み、これによりｐＨ５〜６の緩衝液を形成させ、スマトリプタンの保存安定性を図っていると思われる。また、注射液においては、ｐＨを４．２〜５．３とした塩化ナトリウム水溶液である。
内用液剤の開発には、前記の長期安定性と共に、服用性の問題の解決を図る必要があり、それらの問題を同時に解決することが困難なため、現在まで内用液剤が実用的に開発されなかった理由と考えられる。
As an oral agent currently on the market, there is a tablet containing sumatriptan succinate, and in this tablet, bitterness is prevented by film coating. Other commercially available preparations containing sumatriptan include nasal drops and injectable solutions, but there are no commercially available solutions for internal use.
Nasal solution contains potassium dihydrogen phosphate, anhydrous sodium monohydrogen phosphate, sulfuric acid, and sodium hydroxide, which makes it possible to form a buffer solution of pH 5-6, and to achieve the storage stability of sumatriptan. It is. The injection solution is a sodium chloride aqueous solution having a pH of 4.2 to 5.3.
In order to develop internal use liquid preparations, it is necessary to solve the problems of ingestion in addition to the long-term stability described above, and it is difficult to solve these problems at the same time. The reason was not.
本発明は、長期保存安定性に優れると共に、服用性も改善した、スマトリプタンコハク酸塩を含有する内用液剤の開発を目的とする。 The object of the present invention is to develop an internal solution containing sumatriptan succinate that is excellent in long-term storage stability and improved ingestibility.
上記課題を解決するために鋭意検討したところ、本発明者らは、薬理学上許容しうる有機酸、好ましくは、後記する、ヒドロキシ置換を有してもよい炭素数４〜６のジ又はトリカルボン酸又はアスコルビン酸、及び水を含有する内用液剤は、スマトリプタンコハク酸塩の類縁物質の増加が抑制され、長期保存安定性に優れること、さらに該有機酸のアルカリ金属塩を含む場合、内用液が緩衝化され、保存安定性が向上すると共に、甘味剤との併用により、服用性が改善されることを見出した。また、スマトリプタンコハク酸塩の服用性の改善のための甘味剤としては、甘味剤を少なくとも２種併用することにより、より服用性を高めることができることを見出した。 As a result of diligent studies to solve the above problems, the present inventors have found that the pharmacologically acceptable organic acid, preferably divalent or tricarboxylic having 4 to 6 carbon atoms which may have a hydroxy substitution, which will be described later. An internal solution containing acid or ascorbic acid and water is suppressed in the increase of the related substances of sumatriptan succinate, has excellent long-term storage stability, and further contains an alkali metal salt of the organic acid. It has been found that the liquid for use is buffered, the storage stability is improved, and in combination with the sweetener, the ingestion is improved. In addition, as a sweetener for improving the ingestibility of sumatriptan succinate, it has been found that the ingestibility can be further improved by using at least two kinds of sweeteners in combination.
即ち、本発明は、
（１） スマトリプタンコハク酸塩、薬理学上許容しうる有機酸及び水を含有する内用液剤、
（２） 該薬理学上許容しうる有機酸がヒドロキシ置換を有してもよいＣ４〜Ｃ６脂肪族ジ又はトリカルボン酸、又はアスコルビン酸である上記（１）に記載の内用液剤、
（３） 該薬理学上許容しうる有機酸がクエン酸、アスコルビン酸、リンゴ酸及び酒石酸からなる群から選ばれる少なくとも一種である、上記（１）又は（２）に記載の内用液剤、
（４） さらに有機酸塩を含有する、上記（１）〜（３）の何れか一項に記載の内用液剤、
（５） 該有機酸塩が、該薬理学上許容しうるヒドロキシ置換を有してもよいＣ４〜Ｃ６脂肪族ジ又はトリカルボン酸のアルカリ金属塩、又はアスコルビン酸のアルカリ金属塩である、上記（４）に記載の内用液剤、
（６） 該有機酸がクエン酸であり、該有機酸塩がクエン酸ナトリウムである、上記（５）に記載の内用液剤、
That is, the present invention
(1) Sumatriptan succinate, an internal solution containing a pharmacologically acceptable organic acid and water,
(2) The internal use liquid preparation according to (1), wherein the pharmacologically acceptable organic acid is a C4-C6 aliphatic di- or tricarboxylic acid, or ascorbic acid, which may have a hydroxy substitution,
(3) The internal solution according to (1) or (2), wherein the pharmacologically acceptable organic acid is at least one selected from the group consisting of citric acid, ascorbic acid, malic acid and tartaric acid,
(4) The internal solution according to any one of (1) to (3), further containing an organic acid salt,
(5) The above (4), wherein the organic acid salt is an alkali metal salt of C4-C6 aliphatic di- or tricarboxylic acid, or an alkali metal salt of ascorbic acid, which may have a pharmacologically acceptable hydroxy substitution. 4) internal use liquid preparation according to
(6) The internal solution according to (5), wherein the organic acid is citric acid and the organic acid salt is sodium citrate,
（７） さらに甘味剤を含有する、上記（１）〜（６）の何れか一項に記載の内用液剤、
（８） 甘味剤が、甘味がショ糖の０．５〜５倍である弱甘味剤と甘味がショ糖の１００倍以上の強甘味剤の併用である上記（７）に記載の内用液剤、
（９） 甘味がショ糖の１００倍以上の強甘味剤が、甘味がショ糖の１００倍〜４００倍の中強甘味剤と甘味がショ糖の４００倍以上の超強甘味剤の併用である上記（８）に記載の内用液剤、
（１０） 弱甘味剤としてキシリトール、中強甘味剤としてアセスルファムカリウム及び超強甘味剤としてスクラロースの３者を含有する、上記（９）に記載の内用液剤、
（１１） スマトリプタンコハク酸塩１質量部に対して、それぞれ、弱甘味剤を２〜１０質量部、中強甘味剤を０．０２〜０．１２質量部、超強甘味剤を０．０５〜０．３質量部を含有する、上記（９）又は（１０）に記載の内用液剤、
（１２） ０．１〜７０ｍｇ／ｍＬのスマトリプタンコハク酸塩を含み、該液剤のｐＨが４．４〜５．０である、上記（１）〜（１１）の何れか一項に記載の内用液剤、
（１３） 内用液剤の総量に対して、スマトリプタンコハク酸塩を０．１〜７０ｍｇ／ｍＬ、該薬理学上許容しうる有機酸を０．０２〜３０ｍｇ／ｍＬ、該有機酸塩を０．０２〜４０ｍｇ／ｍＬ、及び、該甘味剤を１〜３２０ｍｇ／ｍＬ含有し、残部が水及び薬学上許容しうる添加剤である、上記（７）〜（１２）の何れか一項に記載の内用液剤、
に関する。
(7) The liquid preparation for internal use according to any one of (1) to (6), further comprising a sweetener,
(8) The internal liquid preparation according to (7), wherein the sweetener is a combination of a weak sweetener having a sweetness of 0.5 to 5 times that of sucrose and a strong sweetener having a sweetness of 100 or more times that of sucrose. ,
(9) A strong sweetener whose sweetness is 100 times or more that of sucrose is a combination of a medium strong sweetener whose sweetness is 100 to 400 times that of sucrose and a super strong sweetener whose sweetness is 400 times or more that of sucrose. Internal use liquid preparation as described in said (8),
(10) The internal liquid preparation according to (9) above, containing xylitol as a weak sweetener, acesulfame potassium as a medium strong sweetener, and sucralose as a super strong sweetener,
(11) With respect to 1 part by mass of sumatriptan succinate, 2 to 10 parts by weight of a sweetener, 0.02 to 0.12 parts by weight of a medium sweetener, and 0.05 of a superstrong sweetener, respectively. -The internal use liquid agent as described in said (9) or (10) containing -0.3 mass part,
(12) The composition according to any one of (1) to (11) above, comprising 0.1 to 70 mg / mL sumatriptan succinate, wherein the pH of the solution is 4.4 to 5.0. Internal solution,
(13) The sumatriptan succinate is 0.1 to 70 mg / mL, the pharmacologically acceptable organic acid is 0.02 to 30 mg / mL, and the organic acid salt is 0 with respect to the total amount of the internal solution. .02 to 40 mg / mL, and 1 to 320 mg / mL of the sweetener, with the balance being water and a pharmaceutically acceptable additive, any one of (7) to (12) above Liquid for internal use,
About.
本発明のスマトリプタンコハク酸塩含有内用液剤は、片頭痛の発現時に、服用のための水を準備すること無く、直ちに服用可能であり、かつ、有機酸、好ましくは水酸基を有してもよい炭素数４〜６のヒドロキシカルボン酸又はアスコルビン酸により、スマトリプタンの類縁物質の増加が抑制され、長期保存安定性に優れる。さらに、該有機酸の塩を含有させることにより、長期保存安定性が向上する。また、更に、甘味剤、特に、弱甘味剤と強甘味剤の少なくとも２種を含有する内用液剤とした場合、スマトリプタンコハク酸塩の有する苦味がマスキングされ、服用感が良好であるという特徴を有する。 The sumatriptan succinate-containing internal preparation of the present invention can be taken immediately without the preparation of water for taking when migraine develops, and has an organic acid, preferably a hydroxyl group. By the good C4-C6 hydroxycarboxylic acid or ascorbic acid, the increase in the related substance of sumatriptan is suppressed, and it is excellent in long-term storage stability. Furthermore, long-term storage stability improves by containing the salt of this organic acid. Furthermore, when the liquid preparation for internal use contains at least two kinds of sweeteners, particularly weak sweeteners and strong sweeteners, the bitter taste of sumatriptan succinate is masked and the feeling of taking is good. Have
本発明を以下により詳しく説明する。
本発明のスマトリプタン内用液剤は、スマトリプタンコハク酸塩、薬理学上許容しうる有機酸及び水を含有する。また、好ましくは、さらに有機酸塩及び／又は甘味剤を含有する。
The invention is described in more detail below.
The solution for internal use of sumatriptan of the present invention contains sumatriptan succinate, a pharmacologically acceptable organic acid and water. Further, preferably, it further contains an organic acid salt and / or a sweetener.
本発明のスマトリプタンコハク酸塩含有内用液剤（以下、本発明のスマトリプタン内用液剤又は本発明の内用液剤という。）に含まれるスマトリプタンコハク酸塩は、市販されているか、又は当業者に既知の方法で、例えば特許文献１（特公平６−２３１９７号公報）に記載の方法又はそれに準じた方法で製造することができる。
本発明の内用液剤におけるスマトリプタンコハク酸塩の含有量は、０．１〜７０ｍｇ／ｍＬ、好ましくは１０〜６０ｍｇ／ｍＬ、より好ましくは３０〜４０ｍｇ／ｍＬである。例えば、本発明の内用液剤がスマトリプタンコハク酸塩として３５ｍｇ／ｍＬを含有する場合、スマトリプタンとしては２５ｍｇ／ｍＬを含有する。
The sumatriptan succinate containing the sumatriptan succinate-containing internal preparation (hereinafter referred to as the sumatriptan internal preparation of the present invention or the internal preparation of the present invention) is commercially available or It can be produced by a method known to those skilled in the art, for example, the method described in Patent Document 1 (Japanese Patent Publication No. 6-23197) or a method analogous thereto.
The content of sumatriptan succinate in the internal use liquid preparation of the present invention is 0.1 to 70 mg / mL, preferably 10 to 60 mg / mL, more preferably 30 to 40 mg / mL. For example, when the internal solution of the present invention contains 35 mg / mL as sumatriptan succinate, the sumatriptan contains 25 mg / mL.
本明細書においては、特に断りのない限り、「部」は質量部を、割合は質量割合をそれぞれ表す（グラムは特に断りが無い限り、質量単位である）。 In the present specification, unless otherwise specified, “parts” represent parts by mass, and ratios represent mass percentages (grams are mass units unless otherwise specified).
また、本発明の内用液剤において、「スマトリプタンコハク酸塩を含有する」といった場合、本発明の内用液剤は水溶液剤であることから、当業者においては当然に理解されるように、実際には該水溶液中においては該コハク酸塩は、イオンとして平衡状態において存在するが、便宜上水溶液中においても、スマトリプタンコハク酸塩として存在するとして取り扱うものである。従って、液剤の原料としてスマトリプタンコハク酸塩を用いた場合は、全て、便宜上そのように取り扱う。また、該水溶液剤中におけるスマトリプタンコハク酸塩の含量という場合も、同様である。本発明の内用液剤中のスマトリプタンは、実際には、例えば塩を形成しないフリーの状態、コハク酸との塩、フリーのコハク酸、更に、コハク酸以外の上記有機酸との塩及びフリーの有機酸等の平衡状態における混合物として存在する。 Further, in the case of “containing sumatriptan succinate” in the liquid preparation for internal use of the present invention, since the liquid preparation for internal use of the present invention is an aqueous solution, it is actually understood by those skilled in the art. In the aqueous solution, the succinate is present as an ion in an equilibrium state, but for convenience, the succinate is treated as existing in the aqueous solution as sumatriptan succinate. Therefore, when sumatriptan succinate is used as the raw material of the liquid agent, it is handled as such for the sake of convenience. The same applies to the sumatriptan succinate content in the aqueous solution. The sumatriptan in the liquid preparation for internal use of the present invention is actually in a free state that does not form a salt, a salt with succinic acid, a free succinic acid, and a salt with the above organic acid other than succinic acid and free It exists as a mixture in an equilibrium state such as organic acids.
本発明の内用液剤に含まれる有機酸としては、薬理学上許容しうる有機酸であり、スマトリプタンコハク酸塩の安定に寄与するものであればいずれも使用できる。 そのような有機酸の好ましいものとしては、例えばリンゴ酸、クエン酸、酒石酸、フマル酸、コハク酸、アジピン酸、グルコン酸等の水酸基を有してもよい炭素数４〜６の脂肪族ジ又はトリカルボン酸、又は、アスコルビン酸（Ｌ体又はＤ体何れであってもよい）を挙げることができる。
なお、水酸基を有してもよい炭素数４〜６の脂肪族ジ又はトリカルボン酸における炭素数は、カルボキシ基における炭素も含めた数である。これらの有機酸は、単独で用いてもよく、又は２種以上の混合物として用いてもよい。通常は単独で用いるのが好ましい。該有機酸としては、クエン酸、リンゴ酸又は酒石酸等の炭素数４〜６の脂肪族ヒドロキシジ又はトリカルボン酸がさらに好ましく、保存安定性の点では、クエン酸又はアスコルビン酸が特に好ましく、着色等のおそれも無く、長期保存安定性もよいという点で、最も好ましいのはクエン酸である。該クエン酸は、スマトリプタン内用液剤の服用性改善の面からも、好ましい。
該有機酸の含有量は、通常、スマトリプタン１質量部に対して０．０１〜１質量部、好ましくは０．０２〜０．５質量部、より好ましくは０．０３〜０．２質量部である。
また本発明の内用液剤における該有機酸の含有量は、０．０２〜３０ｍｇ／ｍＬ、好ましくは０．２〜２０ｍｇ／ｍＬ、より好ましくは０．５〜１０ｍｇ／ｍＬ、特に好ましくは１〜７ｍｇ／ｍＬである。
As the organic acid contained in the internal solution of the present invention, any pharmacologically acceptable organic acid can be used as long as it contributes to the stability of sumatriptan succinate. Preferable examples of such organic acids include, for example, aliphatic diacids having 4 to 6 carbon atoms which may have a hydroxyl group such as malic acid, citric acid, tartaric acid, fumaric acid, succinic acid, adipic acid, and gluconic acid. Examples thereof include tricarboxylic acid or ascorbic acid (which may be either L-form or D-form).
In addition, the carbon number in C4-C6 aliphatic di or tricarboxylic acid which may have a hydroxyl group is a number including the carbon in a carboxy group. These organic acids may be used alone or as a mixture of two or more. Usually, it is preferably used alone. As the organic acid, an aliphatic hydroxydi or tricarboxylic acid having 4 to 6 carbon atoms such as citric acid, malic acid or tartaric acid is more preferable, and citric acid or ascorbic acid is particularly preferable in terms of storage stability, coloring and the like. Most preferred is citric acid in that it has no risk of long-term storage and good long-term storage stability. The citric acid is also preferable from the viewpoint of improving the ingestion of the solution for internal use of sumatriptan.
The content of the organic acid is usually 0.01 to 1 part by weight, preferably 0.02 to 0.5 part by weight, more preferably 0.03 to 0.2 part by weight with respect to 1 part by weight of sumatriptan. It is.
The content of the organic acid in the internal solution of the present invention is 0.02 to 30 mg / mL, preferably 0.2 to 20 mg / mL, more preferably 0.5 to 10 mg / mL, particularly preferably 1 to 1. 7 mg / mL.
本発明の内用液剤において、スマトリプタンコハク酸塩を溶解する溶媒としては水が用いられ、通常、精製水が使用される。当該溶媒には、必要に応じて、他の溶媒、例えば無水エタノール及びエタノール等の有機溶媒等を加えることもできる。通常は水のみが好ましい。 In the internal solution of the present invention, water is used as a solvent for dissolving sumatriptan succinate, and purified water is usually used. If necessary, other solvents such as organic solvents such as absolute ethanol and ethanol can be added to the solvent. Usually only water is preferred.
本発明の内用液剤においては、上記有機酸とともに、緩衝作用示す有機酸塩を含有するのが好ましい。好ましい該有機酸塩としては、ナトリウム塩及びカリウム塩等のアルカリ金属塩を挙げることができ、コスト面などからは、ナトリウム塩がより好ましい。
好ましい有機酸塩としては、前記の好ましい有機酸のアルカリ金属塩であり、より具体的には、水酸基を有してもよい炭素数４〜６の脂肪族ジ又はトリカルボン酸のアルカリ金属塩、又はアスコルビン酸アルカリ金属塩である。通常、有機酸と共に、該有機酸塩を含むことにより、ｐＨ緩衝剤として作用し、内用液剤の安定に寄与すると共に、服用面の改善も認められる。
該有機酸塩は、内用液剤に含まれる有機酸と共に緩衝作用示すものであれば特に限定されないが、通常は、内用液剤に含まれる有機酸の塩が好ましい。該有機酸塩の好ましい具体例としては、クエン酸ナトリウム、クエン酸カリウム、アスコルビン酸ナトリウム、リンゴ酸ナトリウム及び酒石酸ナトリウム等のそれぞれの酸のアルカリ金属塩が挙げられ、それぞれ対応する有機酸と共に内用液剤に含まれるようにするのがより好ましい。例えば、内用液剤に含まれる有機酸がクエン酸の時は、クエン酸のアルカリ金属塩（より好ましくはクエン酸ナトリウム）と組み合わせるのが好ましい。
上記の有機酸塩は、上記有機酸とともに本発明の内用液剤のｐＨを目的の範囲に調整できるように、適量使用すればよい。上記有機酸塩の含有量は、スマトリプタン１質量部に対して、０．０１〜１質量部、好ましくは０．０５〜０．５質量部、より好ましくは０．０５〜０．３質量部である。また、本発明の内用液剤における上記有機酸塩の含有量は、通常０．０２〜４０ｍｇ／ｍＬであり、好ましくは０．２〜２５ｍｇ／ｍＬであり、より好ましくは０．５〜１５ｍｇ／ｍＬであり、特に好ましくは２〜１２ｍｇ／ｍＬである。
In the internal use liquid agent of this invention, it is preferable to contain the organic acid salt which shows a buffer action with the said organic acid. Preferred examples of the organic acid salt include alkali metal salts such as sodium salt and potassium salt, and sodium salt is more preferable from the viewpoint of cost.
Preferable organic acid salt is an alkali metal salt of the above-mentioned preferable organic acid, more specifically, an alkali metal salt of an aliphatic di- or tricarboxylic acid having 4 to 6 carbon atoms which may have a hydroxyl group, or Ascorbic acid alkali metal salt. Usually, by containing the organic acid salt together with an organic acid, it acts as a pH buffering agent, contributes to the stability of the internal solution, and improvement of the dosage is recognized.
The organic acid salt is not particularly limited as long as it exhibits a buffering action together with the organic acid contained in the internal solution, but usually a salt of the organic acid contained in the internal solution is preferable. Preferable specific examples of the organic acid salt include alkali metal salts of respective acids such as sodium citrate, potassium citrate, sodium ascorbate, sodium malate and sodium tartrate. More preferably, it is included in the liquid agent. For example, when the organic acid contained in the internal solution is citric acid, it is preferably combined with an alkali metal salt of citric acid (more preferably sodium citrate).
What is necessary is just to use said organic acid salt in a suitable quantity so that the pH of the internal solution of this invention can be adjusted to the target range with the said organic acid. The content of the organic acid salt is 0.01 to 1 part by mass, preferably 0.05 to 0.5 part by mass, and more preferably 0.05 to 0.3 part by mass with respect to 1 part by mass of sumatriptan. It is. Moreover, content of the said organic acid salt in the liquid for internal use of this invention is 0.02-40 mg / mL normally, Preferably it is 0.2-25 mg / mL, More preferably, it is 0.5-15 mg / mL. mL, particularly preferably 2 to 12 mg / mL.
本発明の薬理学上許容しうる有機酸と、有機酸塩との組み合わせの好ましい具体例としては、上記有機酸がクエン酸、アスコルビン酸、リンゴ酸及び酒石酸のいずれかであり、上記有機酸塩がそれぞれ対応する有機酸のアルカリ金属塩、好ましくはナトリウム塩又はカリウム塩である組み合わせが挙げられる。クエン酸とクエン酸ナトリウムとの組み合わせが最も好ましい。 As a preferred specific example of the combination of the pharmacologically acceptable organic acid and the organic acid salt of the present invention, the organic acid is any one of citric acid, ascorbic acid, malic acid and tartaric acid, and the organic acid salt Are combinations of alkali metal salts, preferably sodium salts or potassium salts of the corresponding organic acids. A combination of citric acid and sodium citrate is most preferred.
上記有機酸及び上記有機酸塩及びその含有量を適宜調整することにより、本発明の内用液剤のｐＨを一定の範囲に調整することが好ましい。本発明の内用液剤のｐＨは、通常４．２〜５．３程度であれば良いが、長期安定性の面からは、好ましくは４．４〜５．０程度であり、特に好ましくは４．６〜４．８程度である。これらの範囲に調整することにより、スマトリプタンに由来する特定の不純物の増加が抑制された、より安定な内用液剤を得ることができる。 It is preferable to adjust the pH of the internal solution of the present invention to a certain range by appropriately adjusting the organic acid, the organic acid salt, and the content thereof. The pH of the internal liquid preparation of the present invention may be usually about 4.2 to 5.3, but is preferably about 4.4 to 5.0, particularly preferably 4 from the viewpoint of long-term stability. About 6 to 4.8. By adjusting to these ranges, it is possible to obtain a more stable internal liquid preparation in which an increase in specific impurities derived from sumatriptan is suppressed.
本発明の内用液剤には、服用性を改善するために、甘味剤を含有するのが好ましい。該甘味剤としては、糖、糖アルコール又は合成甘味料がある。
本発明の内用液剤に使用しうる甘味剤の具体例としては、例えば、ショ糖、液糖、果糖、果糖ブドウ糖液、ブドウ糖果糖液糖、黒砂糖、高果糖液糖、ブドウ糖、乳糖、白糖、精製白糖、精製白糖球状顆粒、ハチミツ、精製ハチミツ及び単シロップなどの糖；エリスリトール、キシリトール、Ｄ−ソルビトール、Ｄ−ソルビトール液、マルチトール、マルチトール液、マルトース及びＤ−マンニトールなどの糖アルコール；アマチャ抽出物、甘草抽出物、ステビア抽出物等の植物抽出甘味料；アスパルテーム、アセスルファムカリウム、サッカリン、サッカリンナトリウム、スクラロース、ネオテーム、ソーマチン、グリシン、グリセリン、グリチルリチン酸二カリウム、グリチルリチン酸二ナトリウム、グリチルリチン酸三ナトリウム及びグリチルリチン酸モノアンモニウムなどの合成甘味料が挙げられる。
The internal use liquid preparation of the present invention preferably contains a sweetening agent in order to improve ingestion. Such sweeteners include sugars, sugar alcohols or synthetic sweeteners.
Specific examples of sweeteners that can be used in the liquid preparation for internal use of the present invention include, for example, sucrose, liquid sugar, fructose, fructose glucose liquid, glucose fructose liquid sugar, brown sugar, high fructose liquid sugar, glucose, lactose, sucrose Sugars such as purified sucrose, purified sucrose spherical granules, honey, purified honey and simple syrup; sugar alcohols such as erythritol, xylitol, D-sorbitol, D-sorbitol, maltitol, maltitol, maltose and D-mannitol; Plant extract sweeteners such as amateur extract, licorice extract, stevia extract, etc .; aspartame, acesulfame potassium, saccharin, saccharin sodium, sucralose, neotame, thaumatin, glycine, glycerin, dipotassium glycyrrhizinate, disodium glycyrrhizinate, glycyrrhizic acid tri Sodium and Gu Synthetic sweeteners such as Chirurichin acid mono ammonium.
上記の甘味剤は、本発明の内用液剤に、１種単独で、又は２種以上を組み合わせて使用することができる。本発明のスマトリプタンコハク酸塩を含有する内用液剤においては、スマトリプタンコハク酸塩の不快な味（苦味等）をマスキングでき、安定性に悪影響を与えないものであれば何れの甘味剤でも使用出来るが、本発明者らの検討によれば、本発明においては、糖又は糖アルコール等のように甘味がショ糖の０．５〜５倍の弱甘味剤と甘味がショ糖の１００倍以上の強甘味剤との併用が好ましい。また、強甘味剤も、甘味がショ糖の１００〜４００倍程度の中強甘味剤と甘味がショ糖の４００倍以上の超強甘味剤との併用がより好ましい。このように２種又は３種の甘味剤を組み合わせることにより、スマトリプタンコハク酸塩の水溶液における不快な味（苦味等）をマスキングできると共に、服用後の後味等も改善することができる。
甘味がショ糖の１００〜４００倍の中強甘味剤としては通常合成甘味剤が挙げられ、具体的には、アスパルテーム、アセスルファムカリウム等であり、好ましくは甘味がショ糖の２００〜３００倍程度の甘味剤であり、より好ましくはアセスルファムカリウムである。
The above sweeteners can be used alone or in combination of two or more in the liquid preparation for internal use of the present invention. In the internal use liquid preparation containing sumatriptan succinate of the present invention, any sweetener can be used as long as it can mask the unpleasant taste (bitter taste etc.) of sumatriptan succinate and does not adversely affect the stability. Although it can be used, according to the study of the present inventors, in the present invention, a sweetener having a sweetness of 0.5 to 5 times that of sucrose and a sweetness of 100 times that of sucrose, such as sugar or sugar alcohol. The combined use with the above intense sweeteners is preferred. Further, the strong sweetener is more preferably used in combination with a medium strong sweetener having a sweetness of about 100 to 400 times that of sucrose and a super strong sweetener having a sweetness of 400 times or more that of sucrose. Thus, by combining two or three kinds of sweeteners, it is possible to mask unpleasant taste (bitter taste and the like) in an aqueous solution of sumatriptan succinate, and to improve the aftertaste after taking.
Examples of medium sweeteners whose sweetness is 100 to 400 times that of sucrose usually include synthetic sweeteners, specifically, aspartame, acesulfame potassium, etc., and preferably sweetness is about 200 to 300 times that of sucrose. A sweetener, more preferably acesulfame potassium.
また、甘味がショ糖の４００倍以上の超強甘味剤としては具体的には、サッカリン、サッカリンナトリウム、ネオテーム、スクラロース等であり、より好ましくは甘味がショ糖の５００倍以上の甘味剤が好ましく、最も好ましくはスクラロースである。
本発明においては、弱甘味剤の少なくとも一種と強甘味剤の少なくとも一種を併用するのが好ましく、より好ましくは強甘味剤として、中強甘味剤と超強甘味剤の二種を併用する態様である。
本発明においては、上記のように、甘味剤を含むことにより、スマトリプタンコハク酸塩の苦味をほとんど感じることなく、服用時の味、及び服用後の後味も良好にすることができる。
好ましい併用としては、強甘味剤として、甘味が強く、その甘みがショ糖の１００倍以上の合成甘味料、より好ましくはアセスルファムカリウム及びスクラロースの少なくとも１種と糖アルコールとの併用を挙げることができる。
糖アルコールとしては、前記したものの中ではキシリトールがより好ましい。
従って、服用性をより良く改善できる弱甘味剤として、糖アルコール、好ましくはキシリトールを用い、強甘味剤としてアセスルファムカリウム及びスクラロースから選ばれる少なくとも１種（好ましくは両者）を用いることが好ましい。
Specific examples of the super-strong sweetener whose sweetness is 400 times or more that of sucrose are saccharin, saccharin sodium, neotame, sucralose, and the like, and more preferably a sweetener whose sweetness is 500 times or more that of sucrose, Most preferred is sucralose.
In the present invention, it is preferable to use at least one kind of weak sweetener and at least one kind of strong sweetener in combination, and more preferably, as a strong sweetener, two kinds of medium sweetener and super strong sweetener are used in combination. is there.
In the present invention, as described above, by containing a sweetener, the bitter taste of sumatriptan succinate can be hardly felt, and the taste at the time of taking and the aftertaste after taking can be improved.
As a preferred combination, as a strong sweetener, a combination of a sweetener with a strong sweetness and a sweetness that is at least 100 times that of sucrose, more preferably at least one of acesulfame potassium and sucralose, and a sugar alcohol can be mentioned. .
Among the above-mentioned sugar alcohols, xylitol is more preferable as the sugar alcohol.
Therefore, it is preferable to use a sugar alcohol, preferably xylitol, as a weak sweetener that can improve the ingestion better, and use at least one (preferably both) selected from acesulfame potassium and sucralose as a strong sweetener.
本発明における甘味剤は、内用液剤のスマトリプタンコハク酸塩の不快な味、特に苦味を感じなくして、服用感を改良するために添加される。服用感は人により、かなりの差があり、更に甘味剤の種類により、その配合量は大きく異なるため、一概に含量を決めるのは難しい。
本発明の内用液剤において、甘味剤として、甘味がショ糖の１００倍以上の強甘味剤と上記弱甘味剤とを併用する場合、該内用液剤における甘味剤の含量は、スマトリプタン１質量部に対して、５．０〜１０．５質量部、好ましくは６．６〜１０．０質量部、より好ましくは７．５〜９．０質量部である。
また、本発明の内用液剤における甘味剤の含有量は、甘味剤の種類により大幅に異なり、甘味の強い甘味剤では少量で良く、甘味の弱いものでは多くなる。従って、通常１〜３２０ｍｇ／ｍＬ程度の範囲内となる。好ましくは５〜３２０ｍｇ／ｍＬである。甘味の強い強甘味剤（通常合成甘味剤）とショ糖などの弱甘味剤（好ましくは糖アルコール、より好ましくはキシリトール）を併用する場合は、甘味剤の含有量は、好ましくは１００〜３２０ｍｇ／ｍＬ程度、より好ましくは１６０〜２５０ｍｇ／ｍＬである。
甘味がショ糖の１００倍以上の強甘味剤と弱甘味剤（好ましくは糖アルコール、より好ましくはキシリトール）の併用の場合、両者の比率は、強甘味剤１質量部に対して、弱甘味剤（例えば糖アルコール等）が１０〜３００質量部程度、好ましくは２０〜２００質量部程度、より好ましくは３０〜１００質量部程度である。
The sweetener in the present invention is added in order to improve the feeling of taking without feeling unpleasant taste, particularly bitter taste of sumatriptan succinate as an internal solution. The feeling of dosing varies considerably from person to person, and the amount of the compound varies greatly depending on the type of sweetener, so it is difficult to determine the content in general.
In the internal use liquid preparation of the present invention, when a strong sweetener whose sweetness is 100 times or more that of sucrose and the above weak sweetener are used in combination, the content of the sweetener in the internal use liquid preparation is 1 mass of sumatriptan. Parts is 5.0 to 10.5 parts by mass, preferably 6.6 to 10.0 parts by mass, and more preferably 7.5 to 9.0 parts by mass.
In addition, the content of the sweetener in the liquid preparation for internal use of the present invention varies greatly depending on the type of sweetener, and a small amount may be used for a sweetener with a high sweetness, and a large amount for a sweetener with a low sweetness. Therefore, it is usually in the range of about 1 to 320 mg / mL. Preferably it is 5-320 mg / mL. When a strong sweetener with high sweetness (usually a synthetic sweetener) and a weak sweetener such as sucrose (preferably a sugar alcohol, more preferably xylitol) are used in combination, the content of the sweetener is preferably 100 to 320 mg / About mL, more preferably 160 to 250 mg / mL.
In the case of the combined use of a strong sweetener and sweetener (preferably a sugar alcohol, more preferably xylitol) having a sweetness 100 times or more that of sucrose, the ratio of both is weak sweetener relative to 1 part by weight of the strong sweetener. (For example, sugar alcohol etc.) is about 10-300 mass parts, Preferably it is about 20-200 mass parts, More preferably, it is about 30-100 mass parts.
本発明の内用液剤における弱甘味剤（好ましくは糖アルコール、より好ましくはキシリトール）のスマトリプタンに対する含有割合は、スマトリプタン１質量部に対して５．０〜１０．０質量部、好ましくは６．５〜９．５質量部、より好ましくは７．５〜８．５質量部である。また、本発明の内用液剤における弱甘味剤（好ましくは糖アルコール、より好ましくはキシリトール）の含有量は、通常５０〜４００ｍｇ／ｍＬであり、好ましくは１００〜３００ｍｇ／ｍＬであり、より好ましくは１５０〜２５０ｍｇ／ｍＬである。 The content ratio of the weakly sweetener (preferably sugar alcohol, more preferably xylitol) to sumatriptan in the internal solution of the present invention is 5.0 to 10.0 parts by mass, preferably 6 to 1 part by mass of sumatriptan. 0.5 to 9.5 parts by mass, more preferably 7.5 to 8.5 parts by mass. The content of the weak sweetener (preferably sugar alcohol, more preferably xylitol) in the internal use liquid preparation of the present invention is usually 50 to 400 mg / mL, preferably 100 to 300 mg / mL, more preferably 150-250 mg / mL.
本発明において、強甘味剤のスマトリプタンに対する含有割合は、スマトリプタン１質量部に対して、０．０５〜０．９質量部、好ましくは０．１〜０．７質量部、より好ましくは０．１５〜０．６質量部程度である。
本発明における好ましい中強甘味剤の一つとして用いられるアセスルファムカリウムは、白色の結晶性粉末で、熱、弱酸性、弱アルカリ性に対して安定な、カロリーのない甘味料である。本発明の内用液剤における中強甘味剤（好ましくはアセスルファムカリウム）のスマトリプタンに対する含有割合は、スマトリプタン１質量部に対して０．０１〜０．１６質量部、好ましくは０．０５〜０．１２質量部、より好ましくは０．０７〜０．１質量部である。また、本発明の内用液剤における中強甘味剤（好ましくはアセスルファムカリウム）の含有量は、通常０．１〜８ｍｇ／ｍＬであり、好ましくは０．５〜５ｍｇ／ｍＬであり、より好ましくは１〜３ｍｇ／ｍＬである。
In the present invention, the content ratio of the strong sweetener to sumatriptan is 0.05 to 0.9 parts by weight, preferably 0.1 to 0.7 parts by weight, and more preferably 0 to 1 part by weight of sumatriptan. About 15 to 0.6 parts by mass.
Acesulfame potassium used as one of the preferred medium strong sweeteners in the present invention is a white crystalline powder, a sweetener without calories, which is stable against heat, weak acidity and weak alkalinity. The content ratio of the medium strength sweetener (preferably acesulfame potassium) in the liquid preparation for internal use of the present invention to sumatriptan is 0.01 to 0.16 parts by weight, preferably 0.05 to 0, per 1 part by weight of sumatriptan. .12 parts by mass, more preferably 0.07 to 0.1 parts by mass. In addition, the content of the medium strong sweetener (preferably acesulfame potassium) in the internal solution of the present invention is usually 0.1 to 8 mg / mL, preferably 0.5 to 5 mg / mL, more preferably 1 to 3 mg / mL.
また、本発明における好ましい超強甘味剤の一つとして用いられるスクラロースは、砂糖の約６００倍の甘味度を持ち、苦味や渋みがほとんどなく、熱安定性も高い高甘味度甘味料である。本発明の内用液剤における超強甘味剤（好ましくはスクラロース）のスマトリプタンに対する含有割合は、スマトリプタン１質量部に対して０．０１〜０．４質量部、好ましくは０．０５〜０．３５質量部、より好ましくは０．１〜０．３質量部である。また、本発明の内用液剤における超強甘味剤（好ましくはスクラロース）の含有量は、通常０．０５〜２０ｍｇ／ｍＬであり、好ましくは０．５〜１５ｍｇ／ｍＬであり、より好ましくは２〜８ｍｇ／ｍＬである。
本発明において、強甘味剤として、中強甘味剤（好ましくはアセスルファムカリウム）と超強甘味剤（好ましくはスクラロース）を併用する場合、両者の割合は、中強甘味剤１質量部に対して、超強甘味剤を０．５〜８質量部、好ましくは１〜６質量部、より好ましくは、１．５〜３．５質量部程度である。
Moreover, sucralose used as one of the preferred super-strong sweeteners in the present invention is a high-intensity sweetener having a sweetness of about 600 times that of sugar, almost no bitterness and astringency, and high heat stability. The content ratio of the super-strong sweetener (preferably sucralose) to sumatriptan in the internal use liquid preparation of the present invention is 0.01 to 0.4 parts by mass, preferably 0.05 to 0.00 parts by mass with respect to 1 part by mass of sumatriptan. 35 parts by mass, more preferably 0.1 to 0.3 parts by mass. Moreover, the content of the super-strong sweetener (preferably sucralose) in the internal solution of the present invention is usually 0.05 to 20 mg / mL, preferably 0.5 to 15 mg / mL, more preferably 2 ~ 8 mg / mL.
In the present invention, as a strong sweetener, when a medium strong sweetener (preferably acesulfame potassium) and a super strong sweetener (preferably sucralose) are used in combination, the ratio of both is 1 part by weight of the medium strong sweetener, The amount of super sweetening agent is 0.5 to 8 parts by mass, preferably 1 to 6 parts by mass, and more preferably about 1.5 to 3.5 parts by mass.
上述のとおり、本発明における甘味剤としては、甘味がショ糖の１００倍以上の強甘味剤と弱甘味剤の併用が好ましく、より好ましくは、強甘味剤として中強甘味剤と超強甘味剤の併用であり、最も好ましくは、キシリトール、アセスルファムカリウム及びスクラロースの３種の併用である。この３者併用の場合、スマトリプタンに対するそれぞれの好ましい含有割合は、前記した通り、スマトリプタン１質量部に対して、キシリトールが７．５〜８．５質量部、アセスルファムカリウムが０．０７〜０．１質量部、スクラロースが０．１〜０．３質量部である。キシリトール、アセスルファムカリウム及びスクラロースを上記の割合で含有する本発明の内用液剤は、特に良好な服用性を有する。 As described above, the sweetener in the present invention is preferably a combination of a strong sweetener having a sweetness 100 times or more that of sucrose and a weak sweetener, more preferably a medium strong sweetener and a super strong sweetener as the strong sweetener. Most preferably, three types of combinations of xylitol, acesulfame potassium and sucralose are used. In the case of the combination of the three, the preferable content ratios with respect to sumatriptan are, as described above, 7.5 to 8.5 parts by mass of xylitol and 0.07 to 0 of acesulfame potassium with respect to 1 part by mass of sumatriptan. 0.1 parts by mass, and sucralose is 0.1-0.3 parts by mass. The internal use liquid preparation of the present invention containing xylitol, acesulfame potassium and sucralose in the above proportions has particularly good ingestibility.
本発明の内用液剤に含有させることのできる甘味剤は、スマトリプタンコハク酸塩の保存安定性に、悪影響を与えないものは何れも使用可能である。甘味剤の前記弱甘味剤として、キシリトールを用いる場合は、むしろ内用液剤の安定性に好ましい効果を有する。 As the sweetening agent that can be contained in the internal use liquid preparation of the present invention, any sweetener that does not adversely affect the storage stability of sumatriptan succinate can be used. When xylitol is used as the sweetening agent, it has a favorable effect on the stability of the internal solution.
その他、本発明の内用液剤には、薬理学上許容しうる添加剤として、必要に応じて、等張化剤、防腐剤、界面活性剤、及び、その他の医薬液体製剤に通常用いられる添加剤をさらに添加することができる。
等張化剤としては、例えばグリセリン、濃グリセリン、プロピレングリコール、ポリエチレングリコール、トリハロース、シュクロース、ソルビトール、マンニトール、塩化ナトリウム、塩化カリウム、塩化カルシウム及び塩化マグネシウム等を挙げることができる。
防腐剤としては、例えば塩化ベンザルコニウム、メチルパラベン、エチルパラベン、プロピルパラベン、ブチルパラベン、クロロブタノール及び安息香酸ナトリウム等を挙げることができる。
界面活性剤としては、例えばポリソルベート６０、ポリソルベート８０、ポリオキシル３５ヒマシ油、ポリオキシエチレン硬化ヒマシ油、ショ糖脂肪酸エステル、グリセリン脂肪酸エステル、ステアリン酸ポリオキシル４０、マクロゴール２００、マクロゴール４００、マクロゴール６００、マクロゴール２０００及びラウロマクロゴール等を挙げることができる。
In addition, in the internal use liquid preparation of the present invention, as a pharmacologically acceptable additive, if necessary, an isotonic agent, an antiseptic, a surfactant, and other additives usually used in pharmaceutical liquid preparations Further agents can be added.
Examples of the isotonic agent include glycerin, concentrated glycerin, propylene glycol, polyethylene glycol, trihalose, sucrose, sorbitol, mannitol, sodium chloride, potassium chloride, calcium chloride, and magnesium chloride.
Examples of the preservative include benzalkonium chloride, methyl paraben, ethyl paraben, propyl paraben, butyl paraben, chlorobutanol and sodium benzoate.
Examples of the surfactant include polysorbate 60, polysorbate 80, polyoxyl 35 castor oil, polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester, glycerin fatty acid ester, polyoxyl 40 stearate, macrogol 200, macrogol 400, and macrogol 600. , Macrogol 2000, Lauro Macrogol and the like.
その他の医薬液体製剤に通常用いられる添加剤としては、例えばアルギン酸ナトリウム、カルボキシビニルポリマー、カルメロースナトリウム、キサンタンガム、結晶セルロース、カルメロースナトリウム、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース及びポリビニルアルコール等の粘稠剤；天然着色料（カラメル、β−カロチン等）及び合成着色料（食用色素、リン酸リボフラビンナトリウム等）等の着色料；オレンジ油、レモン油、メントール、バニリン、ハチミツ、果実系フレーバー（ストロベリー、パイナップル、オレンジ、アップル、レモン、ライム、グレープフルーツ等）、生薬系フレーバー（ハーブ、ミント等）、ドリンク系フレーバー（ココア、紅茶、ラムネ等）及び菓子系フレーバー（チョコレート、ヨーグルト等）等の香料等が含まれるが、これらに限定されない。
これら添加剤のうち、好ましい添加剤としては、天然着色料、防腐剤、香料等を挙げることができる。
上記の薬理学上許容しうる添加剤の含有量の範囲は、通常０〜２０ｍｇ／ｍＬ程度、好ましくは０〜１０ｍｇ／ｍＬ程度、より好ましくは０〜５ｍｇ／ｍＬ程度である。
Additives commonly used in other pharmaceutical liquid formulations include, for example, sodium alginate, carboxyvinyl polymer, carmellose sodium, xanthan gum, crystalline cellulose, carmellose sodium, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, and polyvinyl alcohol. Thickeners; natural colorants (caramel, β-carotene, etc.) and synthetic colorants (food dyes, riboflavin sodium phosphate, etc.); orange oil, lemon oil, menthol, vanillin, honey, fruit flavors ( Strawberry, pineapple, orange, apple, lemon, lime, grapefruit, etc.), herbal flavours (herbs, mint, etc.), drink flavors (cocoa, tea, ramune, etc.) and Confectionery-based flavors (chocolate, yoghurt, etc.) but are flavors such as, but not limited to.
Among these additives, preferred additives include natural colorants, preservatives, and fragrances.
The range of the content of the pharmacologically acceptable additive is usually about 0 to 20 mg / mL, preferably about 0 to 10 mg / mL, more preferably about 0 to 5 mg / mL.
本発明の内用液剤における、上記各成分の含有量を、好ましい場合も含めて例示すれば、下記の通りである。
スマトリプタンコハク酸塩：０．１〜７０ｍｇ／ｍＬ、好ましくは１０〜６０ｍｇ／ｍＬ、より好ましくは３０〜４０ｍｇ／ｍＬ、
薬理学上許容しうる有機酸：０．０２〜３０ｍｇ／ｍＬ、好ましくは０．２〜２０ｍｇ／ｍＬ、より好ましくは０．５〜１０ｍｇ／ｍＬ、特に好ましくは１〜７ｍｇ／ｍＬ
有機酸塩：０．０２〜４０ｍｇ／ｍＬ、好ましくは０．２〜２５ｍｇ／ｍＬ、より好ましくは０．５〜１５ｍｇ／ｍＬ、特に好ましくは２〜１２ｍｇ／ｍＬ、
甘味剤：１〜３２０ｍｇ／ｍＬ、好ましくは１０〜３２０ｍｇ／ｍＬ、より好ましくは１６０〜２５０ｍｇ／ｍＬ、
水及びその他の薬理学上許容しうる添加剤（防腐剤、香料など）：残部。
さらに、上記甘味剤が、キシリトール、アセスルファムカリウム及びスクラロースである場合の含有量を例示すれば、下記の通りである。
キシリトール：１〜３００ｍｇ／ｍＬ、好ましくは１０〜３００ｍｇ／ｍＬ、より好ましくは１５０〜２５０ｍｇ／ｍＬ、
アセスルファムカリウム：０．１〜８ｍｇ／ｍＬ、好ましくは０．５〜５ｍｇ／ｍＬ、より好ましくは１〜３ｍｇ／ｍＬ、
スクラロース：０．０５〜２０ｍｇ／ｍＬ、好ましくは０．５〜１５ｍｇ／ｍＬ、より好ましくは２〜８ｍｇ／ｍＬ。
Examples of the content of each component in the internal liquid preparation of the present invention, including preferable cases, are as follows.
Sumatriptan succinate: 0.1-70 mg / mL, preferably 10-60 mg / mL, more preferably 30-40 mg / mL,
Pharmacologically acceptable organic acid: 0.02 to 30 mg / mL, preferably 0.2 to 20 mg / mL, more preferably 0.5 to 10 mg / mL, particularly preferably 1 to 7 mg / mL
Organic acid salt: 0.02 to 40 mg / mL, preferably 0.2 to 25 mg / mL, more preferably 0.5 to 15 mg / mL, particularly preferably 2 to 12 mg / mL,
Sweetener: 1-320 mg / mL, preferably 10-320 mg / mL, more preferably 160-250 mg / mL,
Water and other pharmacologically acceptable additives (preservatives, fragrances, etc.): balance.
Furthermore, examples of the content when the sweetener is xylitol, acesulfame potassium and sucralose are as follows.
Xylitol: 1 to 300 mg / mL, preferably 10 to 300 mg / mL, more preferably 150 to 250 mg / mL,
Acesulfame potassium: 0.1-8 mg / mL, preferably 0.5-5 mg / mL, more preferably 1-3 mg / mL,
Sucralose: 0.05-20 mg / mL, preferably 0.5-15 mg / mL, more preferably 2-8 mg / mL.
本発明の内用液剤の各成分を上記の通り含有することにより、長期保存中のスマトリプタン分解物の生成を抑え、かつ、スマトリプタンの苦味が十分に抑制されたスマトリプタンコハク酸塩含有内用液剤を得るという本発明の目的が最適化される。 By containing each component of the liquid preparation for internal use of the present invention as described above, generation of sumatriptan degradation products during long-term storage is suppressed, and the bitter taste of sumatriptan is sufficiently suppressed. The object of the present invention to obtain a solution for use is optimized.
本発明のスマトリプタン内用液剤の製造方法を示す。
本発明の内用液剤は、精製水に、スマトリプタンコハク酸塩、上記有機酸、好ましくは、更に、上記有機酸塩、上記甘味剤及び、必要に応じて、その他添加剤を添加し、溶解した後、通常の方法に従い、例えばメンブランフィルター濾過を行い、得られた濾液を容器に充填することによって、製造することができる。各成分を精製水に添加する際の順序は特に限定されない。次いで、必要に応じて窒素等の不活性ガスによる十分な置換を施した後、容器を密閉することによって、長期保存安定性のよい最終製品を得ることができる。
The manufacturing method of the liquid for internal use of sumatriptan of this invention is shown.
The internal use liquid preparation of the present invention is dissolved in purified water by adding sumatriptan succinate, the above organic acid, preferably the above organic acid salt, the above sweetener, and, if necessary, other additives. Then, according to a usual method, for example, membrane filter filtration is performed, and the obtained filtrate can be filled in a container. The order in which each component is added to purified water is not particularly limited. Next, after sufficient replacement with an inert gas such as nitrogen as necessary, the container is sealed, whereby a final product having good long-term storage stability can be obtained.
本発明の内用液剤の製造においては、容器空隙中の空気を不活性ガスで置換する工程を含むのが好ましい。不活性ガス置換を施された後の容器内は、酸素を実質的に含まないガス雰囲気下であることが望ましいが、容器中のヘッドスペース（容器上部の空隙を言う）の酸素濃度が１０．０容量％以下が好ましく、より好ましくは６容量％以下である。不活性ガスによる置換は、容器内のヘッドスペースのみを置換するだけでも良いが、不活性ガスを、本発明の内用液剤中でバブリングさせることにより、本発明の内用液剤中の溶存酸素を除去又は減少させることもできる。
上記工程に用いられる不活性ガスは、本発明の内用液剤に含有される成分に影響を与えなければ特に制限はないが、窒素ガス、ヘリウム及びアルゴン等が好ましく、窒素ガスがより好ましい。
The production of the internal liquid preparation of the present invention preferably includes a step of replacing the air in the container gap with an inert gas. The inside of the container after the inert gas replacement is preferably in a gas atmosphere that does not substantially contain oxygen. However, the oxygen concentration in the head space (referring to the void at the top of the container) in the container is 10. 0 volume% or less is preferable, More preferably, it is 6 volume% or less. The replacement with the inert gas may replace only the head space in the container. However, by bubbling the inert gas in the internal solution of the present invention, the dissolved oxygen in the internal solution of the present invention is changed. It can also be removed or reduced.
The inert gas used in the above step is not particularly limited as long as it does not affect the components contained in the internal solution of the present invention, but nitrogen gas, helium, argon and the like are preferable, and nitrogen gas is more preferable.
また、本発明のスマトリプタン内用液剤は、上記の不活性ガス置換の後、容器を密封するのが好ましい。上述のとおり、内用液剤中のスマトリプタンは、ｐＨ又は酸素により分解される可能性があることから、これらの影響をできるだけ受けないようにするためである。 Moreover, it is preferable that the liquid for internal use of sumatriptan of this invention seals a container after said inert gas substitution. As described above, sumatriptan in the liquid for internal use may be decomposed by pH or oxygen so that it is not affected as much as possible.
本発明の内用液剤は経口剤として用いることができ、本発明の内用液剤を用時希釈などせずにそのまま投与することが可能である。本発明の内用液剤の１容器あたりの製剤全量（容量または質量）は、医薬品として使用されるにあたっての貯蔵、流通及びそれに続く使用を考慮して適宜選択しうる。医療施設における保管のスペース、使用時の簡便性及び投与時の無菌性の維持などを考慮し、１容器あたり１回使用量の製剤を充填することが好ましい。１回使用量として好適な製剤全量（容量）は０．１ｍＬ〜２０ｍＬ／１容器であり、特に好ましくは０．５ｍＬ〜１０ｍＬ／１容器である。 The internal solution of the present invention can be used as an oral preparation, and the internal solution of the present invention can be administered as it is without dilution at the time of use. The total amount (capacity or mass) of the liquid preparation for internal use of the present invention per container can be appropriately selected in consideration of storage, distribution and subsequent use when used as a pharmaceutical product. In consideration of storage space in a medical facility, convenience during use, and maintenance of sterility during administration, it is preferable to fill a single use amount of the preparation per container. The total amount (volume) of the preparation suitable as a single use amount is 0.1 mL to 20 mL / 1 container, particularly preferably 0.5 mL to 10 mL / 1 container.
本発明の内用液剤を充填する容器としては、薬理学的に許容できる容器であって、上記範囲の容量の製剤を充填でき、かつ、密封可能な容器であれば、いずれも好適に使用できる。また、容器の素材は薬理学的に許容できる任意のものを使用できる。かかる素材としては、ガラス、プラスチック及びアルミラミネートフィルム等が挙げられる。かかる素材は、酸素透過性の低い素材を用いることが望ましい。 As the container for filling the internal solution of the present invention, any container that is pharmacologically acceptable and that can be filled with a preparation having a capacity in the above range and can be sealed can be used suitably. . The material of the container can be any pharmacologically acceptable. Examples of such materials include glass, plastic, and aluminum laminate film. As such a material, it is desirable to use a material having low oxygen permeability.
実施例１
表１及び表２の処方並びに下記製法にて、本発明の実施例１−１、実施例１−２及び比較例１のスマトリプタン内用液剤を製造した。
下記表１の処方に従い、スマトリプタンコハク酸塩、キシリトール、スクラロース及びアセスルファムカリウムを精製水に溶解した。実施例１−１及び１−２の溶液についてはさらに、Ｌ−アスコルビン酸又はクエン酸を下記表２の濃度になる様に添加し、精製水で補正した。こうして実施例１−１、実施例１−２及び比較例１のスマトリプタン内用液剤を得た。得られたそれぞれの内用液剤１６．７５ｍＬを容器（２５ｍＬガラスバイアル）に充填し、次いで容器内のヘッドスペースを窒素ガス置換することにより、ヘッドスペース内の酸素濃度を５容量％とした後、密閉した。
Example 1
The sumatriptan internal solution of Example 1-1 of this invention, Example 1-2, and the comparative example 1 was manufactured by the prescription of Table 1 and Table 2, and the following manufacturing method.
Sumatriptan succinate, xylitol, sucralose, and acesulfame potassium were dissolved in purified water according to the formulation shown in Table 1 below. For the solutions of Examples 1-1 and 1-2, L-ascorbic acid or citric acid was further added so as to have the concentration shown in Table 2 below, and the solution was corrected with purified water. In this way, the liquid for internal use of sumatriptan of Example 1-1, Example 1-2, and Comparative Example 1 was obtained. After filling each obtained internal solution 16.75mL into a container (25mL glass vial), and then substituting the head space in the container with nitrogen gas, the oxygen concentration in the head space was adjusted to 5% by volume, Sealed.
［表２］
添加する酸 濃度
実施例１−１ Ｌ−アスコルビン酸 ０．０２ｍｏｌ／Ｌ
実施例１−２ クエン酸 ０．０２ｍｏｌ／Ｌ
比較例１ 添加せず
[Table 2]
Acid concentration to be added
Example 1-1 L-ascorbic acid 0.02 mol / L
Example 1-2 Citric acid 0.02 mol / L
Comparative Example 1 Without addition
試験例１（純度試験）
実施例１−１、実施例１−２及び比較例１の各検体を恒温槽に入れ、６０℃の環境下に１週間及び２週間保存した。各製剤について、下記の方法で純度試験を実施した。結果を表３に示す。
各製剤につき、上記表１の処方をもとにスマトリプタンコハク酸塩30mgに対応する量をとり、これを下記の移動相に溶かして10mLとし、試料溶液とした。該試料溶液1mLを正確に量り、下記の移動相を加えて正確に100mLとした。さらにこの液1mLを正確に量り、下記の移動相を加えて正確に10mLとし、標準溶液とした。各試料溶液につき、下記の条件で高速液体クロマトグラフィーにより定量分析を行った。それぞれの試料溶液及び標準溶液につき、スマトリプタンコハク酸塩由来のピーク面積、及び、各類縁物質由来のピーク面積を、自動積分法により測定した。
Test Example 1 (Purity test)
Each specimen of Example 1-1, Example 1-2, and Comparative Example 1 was placed in a thermostatic bath and stored in an environment of 60 ° C. for 1 week and 2 weeks. About each formulation, the purity test was implemented by the following method. The results are shown in Table 3.
For each preparation, an amount corresponding to 30 mg of sumatriptan succinate was taken based on the prescription in Table 1 above, dissolved in the following mobile phase to make 10 mL, and used as a sample solution. 1 mL of the sample solution was accurately weighed and the following mobile phase was added to make exactly 100 mL. Furthermore, 1 mL of this solution was accurately weighed, and the following mobile phase was added to make exactly 10 mL to obtain a standard solution. Each sample solution was quantitatively analyzed by high performance liquid chromatography under the following conditions. For each sample solution and standard solution, the peak area derived from sumatriptan succinate and the peak area derived from each related substance were measured by an automatic integration method.
高速液体クロマトグラフィーの測定条件；
検出器：紫外吸光光度計（測定波長：282nm）。
カラム：内径4.0mm、長さ25cmのステンレス管に5μmの液体クロマトグラフィー用オクタデシルシリル化シリカゲルを充てんしたカラム。
カラム温度：25℃付近の一定温度。
移動相：ジブチルアミン0.970g、リン酸0.735g及びリン酸二水素ナトリウム2.93gを水750mLに溶かし、水酸化ナトリウム試液でpHを6.5とし、水を加えて1000mLとして得られた水溶液75容量％と、アセトニトリル25容量％とからなる溶液。
流量：スマトリプタンコハク酸塩の保持時間が約7分になるように調整した。
純度試験の結果を下記表３に示した。下記表３の値は、各保存条件における、類縁物質由来の各ピーク面積の総和／スマトリプタンコハク酸塩由来のピーク面積×１００（％）を表す。
Measurement conditions for high performance liquid chromatography;
Detector: ultraviolet absorption photometer (measurement wavelength: 282 nm).
Column: A stainless steel tube with an inner diameter of 4.0 mm and a length of 25 cm filled with 5 μm of octadecylsilylated silica gel for liquid chromatography.
Column temperature: constant temperature around 25 ° C.
Mobile phase: Dissolving 0.970 g of dibutylamine, 0.735 g of phosphoric acid and 2.93 g of sodium dihydrogen phosphate in 750 mL of water, adjusting the pH to 6.5 with sodium hydroxide test solution, and adding 75 mL of water to obtain 75 mL of aqueous solution. A solution consisting of 25% by volume of acetonitrile.
Flow rate: Adjusted so that the retention time of sumatriptan succinate was about 7 minutes.
The results of the purity test are shown in Table 3 below. The values in Table 3 below represent the sum of the peak areas derived from related substances / the peak area derived from sumatriptan succinate x 100 (%) under each storage condition.
実施例１−１及び１−２の製剤は、比較例１の製剤よりも類縁物質の増加が抑制された。６０℃で２週間経過後の類縁物質の生成量は、比較例１に比べて、実施例１−１が約１２％少なく、実施例１−２が約４９％少なかった。 In the preparations of Examples 1-1 and 1-2, an increase in related substances was suppressed as compared with the preparation of Comparative Example 1. Compared to Comparative Example 1, the production amount of related substances after 2 weeks at 60 ° C. was about 12% less in Example 1-1 and about 49% less in Example 1-2.
実施例２
実施例１と同様に、上記表１及び下記表４の処方、並びに、実施例１に記載の製法にて、本発明の実施例２−１〜２−３及び比較例２−１及び２−２のスマトリプタン内用液剤を得た。なお、比較例２−２では、有機酸に代えて塩酸を使用した。得られたそれぞれの内用液剤（液量１６．５〜１６．６ｍＬ）を容器（２５ｍＬガラスバイアル）に充填し、次いで容器内のヘッドスペースを窒素ガス置換することにより、ヘッドスペース内の酸素濃度を５容量％とした後、密閉した。
Example 2
In the same manner as in Example 1, Examples 2-1 to 2-3 of the present invention and Comparative Examples 2-1 and 2- 2 Sumatriptan internal solution was obtained. In Comparative Example 2-2, hydrochloric acid was used in place of the organic acid. Each of the obtained internal solutions (liquid amount: 16.5 to 16.6 mL) was filled into a container (25 mL glass vial), and then the head space in the container was replaced with nitrogen gas, whereby the oxygen concentration in the head space Was 5% by volume and then sealed.
［表４］
添加する酸 濃度
実施例２−１ クエン酸 ０．０２ｍｏｌ／Ｌ
実施例２−２ 酒石酸 ０．０２ｍｏｌ／Ｌ
実施例２−３ リンゴ酸 ０．０２ｍｏｌ／Ｌ
比較例２−１ 添加せず
比較例２−２ 塩酸 ０．０２ｍｏｌ／Ｌ
[Table 4]
Acid concentration to be added Example 2-1 Citric acid 0.02 mol / L
Example 2-2 Tartaric acid 0.02 mol / L
Example 2-3 Malic acid 0.02 mol / L
Comparative Example 2-1 No addition Comparative Example 2-2 Hydrochloric acid 0.02 mol / L
試験例２（純度試験）
上記試験例１と同様の方法で、実施例２−１〜２−３、比較例２−１及び比較例２−２の各検体について、純度試験を行った。純度試験の結果（スマトリプタンに対する類縁物質のピーク面積比）を表５に示す。
Purity tests were performed on the specimens of Examples 2-1 to 2-3, Comparative Example 2-1, and Comparative Example 2-2 in the same manner as in Test Example 1. Table 5 shows the results of the purity test (peak area ratio of the related substance to sumatriptan).
実施例２−１〜２−３の製剤は、比較例２−１及び比較例２−２の製剤よりも類縁物質の増加が抑制された。 In the preparations of Examples 2-1 to 2-3, an increase in related substances was suppressed as compared with the preparations of Comparative Examples 2-1 and 2-2.
実施例３
上記表１のスマトリプタン内用液剤の処方に従い、スマトリプタンコハク酸塩、キシリトール、スクラロース及びアセスルファムカリウムを精製水に溶解し、さらにクエン酸及びクエン酸ナトリウムを、得られる製剤のクエン酸濃度がそれぞれ０．０２、０．０４及び０．０８ｍｏｌ／Ｌとなるように添加した。このとき、得られる内用液剤のｐＨが４．７付近となるように、実施例３−１〜３−３において、クエン酸及びクエン酸ナトリウムの比率を調整した。上記以外は実施例１と同様にして、実施例３−１〜３−３のスマトリプタン内用液剤を得た。
得られたそれぞれの内用液剤（液量１６．５〜１６．６ｍＬ）を容器（２５ｍＬガラスバイアル）に充填し、次いで容器内のヘッドスペースを窒素ガス置換することにより、ヘッドスペース内の酸素濃度を５容量％とした後、密閉した。
Example 3
In accordance with the formulation of the sumatriptan internal solution in Table 1 above, sumatriptan succinate, xylitol, sucralose and acesulfame potassium are dissolved in purified water, and citric acid and sodium citrate are further added to the citric acid concentration of the resulting preparation. It added so that it might become 0.02, 0.04, and 0.08 mol / L. At this time, in Examples 3-1 to 3-3, the ratio of citric acid and sodium citrate was adjusted so that the pH of the obtained internal solution was about 4.7. Except the above, it carried out similarly to Example 1, and obtained the liquid for internal use of sumatriptan of Examples 3-1 to 3-3.
Each of the obtained internal solutions (liquid amount: 16.5 to 16.6 mL) was filled into a container (25 mL glass vial), and then the head space in the container was replaced with nitrogen gas, whereby the oxygen concentration in the head space Was 5% by volume and then sealed.
試験例３（純度試験（Ｉｍｐｕｒｉｔｙ Ａ））
上記で得られた実施例３−１〜３−３の各検体を恒温槽に入れ、６０℃環境下で２週間保存した後、下記の方法でＩｍｐｕｒｉｔｙ Ａの測定を行った。「Ｉｍｐｕｒｉｔｙ Ａ」とは、スマトリプタンの類縁物質のうちスマトリプタンよりも分子量の大きなものを言い、スマトリプタンの２量体であると考えられる。
結果を表６に示す。
Test Example 3 (Purity Test (Impurity A))
The specimens of Examples 3-1 to 3-3 obtained above were placed in a thermostatic bath and stored for 2 weeks in an environment of 60 ° C., and then Ampurity A was measured by the following method. “Impurity A” refers to a substance having a molecular weight higher than that of sumatriptan among related substances of sumatriptan, and is considered to be a dimer of sumatriptan.
The results are shown in Table 6.
各製剤につき、上記表１の処方をもとに、スマトリプタンコハク酸塩30mgに対応する量をとり、これを下記の移動相に溶かして10mLとし、試料溶液とした。該試料溶液1mLを正確に量り、下記の移動相を加えて正確に100mLとした。さらにこの液1mLを正確に量り、下記の移動相を加えて正確に10mLとしたものを、標準溶液とした。各試料溶液につき、下記の条件で高速液体クロマトグラフィーによる定量分析を行った。それぞれの試料溶液及び標準溶液につき、スマトリプタンコハク酸塩由来のピーク面積、及び、Ｉｍｐｕｒｉｔｙ Ａ由来のピーク面積を、自動積分法により測定した。 For each preparation, an amount corresponding to 30 mg of sumatriptan succinate was taken based on the prescription in Table 1 above, and this was dissolved in the following mobile phase to make 10 mL, which was used as a sample solution. 1 mL of the sample solution was accurately weighed and the following mobile phase was added to make exactly 100 mL. Further, 1 mL of this solution was accurately weighed and the following mobile phase was added to make exactly 10 mL, which was used as a standard solution. Each sample solution was quantitatively analyzed by high performance liquid chromatography under the following conditions. For each sample solution and standard solution, the peak area derived from sumatriptan succinate and the peak area derived from Impurity A were measured by an automatic integration method.
高速液体クロマトグラフィーの測定条件；
検出器：紫外吸光光度計（測定波長：282nm）。
カラム：内径4.6mm、長さ25cmのステンレス管に5μmの液体クロマトグラフィー用シリカゲルを充てんしたカラム。
カラム温度：25℃付近の一定温度。
移動相：メタノール／酢酸アンモニウム溶液（771→1000）の質量比９：１の混液。
流量：２ｍＬ／ｍｉｎ。
純度試験の結果を下記表６に示した。下記表６のＩｍｐｕｒｉｔｙＡの値は、各保存条件における、Ｉｍｕｐｒｉｔｙ Ａ由来のピーク面積／スマトリプタンコハク酸塩由来のピーク面積×１００（％）を表す。
Measurement conditions for high performance liquid chromatography;
Detector: ultraviolet absorption photometer (measurement wavelength: 282 nm).
Column: A column filled with 5 μm silica gel for liquid chromatography in a stainless steel tube with an inner diameter of 4.6 mm and a length of 25 cm.
Column temperature: constant temperature around 25 ° C.
Mobile phase: Mixture of methanol / ammonium acetate solution (771 → 1000) at a mass ratio of 9: 1.
Flow rate: 2 mL / min.
The results of the purity test are shown in Table 6 below. The value of Impurity A in Table 6 below represents the peak area derived from Imuprity A / peak area derived from sumatriptan succinate × 100 (%) under each storage condition.
クエン酸ナトリウムにより緩衝化された実施例３−１〜３−３の各製剤においては、６０℃環境下で２週間保存した後であっても、Ｉｍｐｕｒｉｔｙ Ａの増加を抑制することができた。 In each preparation of Examples 3-1 to 3-3 buffered with sodium citrate, an increase in Impurity A could be suppressed even after storage for 2 weeks in a 60 ° C. environment.
実施例４
下記表７に記載の処方により、原薬及び添加剤を精製水に溶解し、本発明の実施例４のスマトリプタン内用液剤及び比較例４の製剤を得た。それぞれの検体２２ｍＬを容器（２５ｍＬガラスバイアル）に充填し、容器内のヘッドスペースを窒素ガス置換することにより、ヘッドスペース内の酸素濃度を５容量％とした後、密閉した。
Example 4
According to the formulation shown in Table 7 below, the drug substance and additives were dissolved in purified water, and the liquid for internal use of sumatriptan of Example 4 of the present invention and the preparation of Comparative Example 4 were obtained. Each sample (22 mL) was filled in a container (25 mL glass vial), and the head space in the container was replaced with nitrogen gas, so that the oxygen concentration in the head space was 5% by volume and then sealed.
試験例４（純度試験）
実施例４及び比較例４の各製剤を恒温槽に入れ、６０℃の環境下で２週間保存した。その後、各製剤について試験例１と同様の方法で純度試験を行った。純度試験の結果（スマトリプタンに対する類縁物質のピーク面積比）を表８に示す。
Test Example 4 (Purity test)
Each formulation of Example 4 and Comparative Example 4 was placed in a thermostatic bath and stored in an environment of 60 ° C. for 2 weeks. Thereafter, a purity test was performed on each preparation in the same manner as in Test Example 1. Table 8 shows the results of the purity test (peak area ratio of the related substance to sumatriptan).
本発明の実施例４の製剤は、比較例４の製剤に比べて、スマトリプタンの分解によるものと考えられる類縁物質の生成を、およそ３分の１に抑制することができた。 Compared with the preparation of Comparative Example 4, the preparation of Example 4 of the present invention was able to suppress the production of related substances thought to be due to the degradation of sumatriptan to about one third.
実施例５
下記表９に記載の処方により、原薬及び添加剤を精製水に溶解し、本発明の実施例５のスマトリプタン内用液剤及び比較例５の製剤を得た。それぞれの検体２２ｍＬを容器（２５ｍＬガラスバイアル）に充填し、容器内のヘッドスペースを窒素ガス置換することにより、ヘッドスペース内の酸素濃度を５容量％とした後、密閉した。
Example 5
According to the formulation shown in Table 9 below, the drug substance and additives were dissolved in purified water, and the liquid for internal use of sumatriptan of Example 5 of the present invention and the preparation of Comparative Example 5 were obtained. Each sample (22 mL) was filled in a container (25 mL glass vial), and the head space in the container was replaced with nitrogen gas, so that the oxygen concentration in the head space was 5% by volume and then sealed.
試験例５（官能試験）
健康成人６人（パネル：Ａ〜Ｆ）により、実施例５並びに比較例５の各液剤２ｍＬを口に含み、その味（苦味、甘味、清涼感）を総合的に判断し、飲みやすさの評価を実施した。評価は３；苦味、後味の悪さを感じ、飲みにくい、２；苦味はないが、後味の悪さを感じる、１；苦味もなく後味も良好で、飲みやすい、のスコアで行った。結果を表１０に示す。
Test Example 5 (Sensory test)
6 healthy adults (panels: A to F) including 2 mL of each solution of Example 5 and Comparative Example 5 in their mouths, comprehensively judging their taste (bitterness, sweetness, refreshing feeling), and ease of drinking Evaluation was performed. Evaluation was 3; felt bitterness and bad aftertaste and difficult to drink. 2; no bitterness but bad aftertaste. 1; no bitterness and good aftertaste. The results are shown in Table 10.
官能試験の結果、比較例の製剤については６人中５人が飲みにくいと評価したのに対し、本発明の内用液剤については６人中５人が飲みやすいと評価し、飲みにくいと評価したパネルはいなかった。本発明により、スマトリプタンコハク酸塩含有内用液剤の服用性が十分に改善された。 As a result of the sensory test, 5 out of 6 people evaluated that the preparation of the comparative example was difficult to drink, whereas the internal solution of the present invention evaluated that 5 out of 6 people were easy to drink and evaluated that it was difficult to drink. There was no panel. According to the present invention, the ingestibility of the sumatriptan succinate-containing internal solution is sufficiently improved.
本発明によって、用時に即服用可能なスマトリプタンコハク酸塩含有内用液剤であって、長期保存安定性に優れ、かつ、苦味がマスキングされて服用しやすいスマトリプタンコハク酸塩含有内用液剤の提供が可能となる。 According to the present invention, it is a sumatriptan succinate-containing internal preparation that can be taken immediately at the time of use, and is excellent in long-term storage stability and masked bitterness and easy to take. Provision is possible.
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