JP5631701B2 - Urination suppressor - Google Patents

Description

  The present invention relates to a urination-suppressing device, and more specifically, urination is suppressed by pressing a specific part of a human body, thereby preventing frequent urination or urinary incontinence particularly in elderly people or children. This relates to a urination inhibitor.

  A therapeutic / preventive agent for frequent urination or urinary incontinence has already been disclosed in, for example, JP-A-11-1440.

  This therapeutic or preventive agent for pollakiuria or urinary incontinence comprises a compound having a central urinary reflex inhibitory action and a calcium antagonistic action as an active ingredient.

Japanese Patent Laid-Open No. 11-1440

  The conventional therapeutic / prophylactic agents for pollakiuria or urinary incontinence are formulated into powders, granules, tablets, capsules, injections, etc., for example, orally administered, but the present invention relies on drugs. It was intended to provide a simple and inexpensive urination-suppressing device that can prevent frequent urination or urinary incontinence without invading the skin and that can be used very easily by anyone. is there.

  In order to solve the above problems, the present invention provides the following urination-suppressing device.

(1) A pressing part formed of a flexible elastic body having adhesiveness and a flat surface is provided, and the urinary contraction movement of the bladder is suppressed by pressing the perineal part of the human body with the pressing part. In the urination suppression device
The urination inhibitor (Claim 1) , wherein the pressing portion is formed in a columnar shape and includes a handle portion .

(2) The pressing portion is rotatably attached to the handle portion (claim 2).

[Invention of Claim 1]
When the perineal part of the human body is pressed by the pressing part formed of a flexible elastic body having adhesiveness and a flat surface, the urinary contraction movement of the bladder is suppressed. Therefore, this urination suppressor is effective for the treatment of overactive bladder accompanied by urgency due to involuntary contraction of the bladder, and can effectively prevent frequent urination or urinary incontinence particularly in elderly people or children. .

  This urination-suppressing device is simple and inexpensive, and can be used very easily by any person, and can prevent frequent urination or urinary incontinence without relying on drugs. Since the pressing part is formed of a flexible elastic body having a flat surface, pressing the perineal part gives a non-noxious stimulus to the skin of the perineal part. In other words, the skin irritation by the pressing portion has no risk of invasion.

Since the pressing portion is formed in a columnar shape and includes a handle portion, the user can hold the handle portion with fingers and press the perineum portion of the human body with the pressing portion.

[Invention of claim 2]
Since the pressing part is rotatably attached to the handle part, the user grips the handle part with a finger and rotates the pressing part on the perineum part of the human body, thereby making the perineum part more preferable. Can be pressed.

FIG. 1 is a perspective view showing an example of a urination inhibitor. FIG. 2 is a cross-sectional view of the urination inhibitor shown in FIG. FIG. 3 is a side view of the urination inhibitor shown in FIG. FIG. 4 is a perspective view showing another example of the urination inhibitor. FIG. 5 is a cross-sectional view of the urination inhibitor shown in FIG. FIG. 6 is a perspective view showing still another example of the urination inhibitor. FIG. 7 is a cross-sectional view of the urination inhibitor shown in FIG. FIG. 8 is a perspective view showing still another example of the urination inhibitor. FIG. 9 is a cross-sectional view of the urination inhibitor shown in FIG. FIG. 10 is a cross-sectional view showing a modified example of the urination suppressing tool shown in FIG. 3 is a graph showing changes in intravesical pressure in Example 1. 6 is a graph showing changes in intravesical pressure in Comparative Example 1.

  The urination-suppressing device according to the present invention includes a pressing portion 1 formed of a flexible elastic body having adhesiveness and a flat surface. By pressing the perineal portion of the human body with the pressing portion 1, the bladder The urination contraction movement is suppressed.

The perineum (perineum) is the part between the urination opening and the anus. That is, the length of the perineum varies significantly from person to person. The length of the female perineum is about 3 to 5 cm, but the male perineum is generally wider than the female perineum.

The pressing part 1 needs to have moderate adhesiveness. The pressing portion 1 is formed of a flexible elastic body having a flat surface so as to give a non-nociceptive stimulus to the skin of the perineum by pressing the perineum.

The pressing part 1 should preferably press the perineum with a pressing force of about 4 to 20 g, more preferably about 12 g.

The elastic body forming the pressing portion 1 is preferably an elastomer. As the elastomer, for example, a thermoplastic elastomer, a thermoplastic polyurethane elastomer, or the like is used. The elastic body forming the pressing part 1 may be a gel.

  The pressing portion 1 a in the example shown in FIGS. 1 to 3 is formed in a columnar shape and includes a handle portion 3. In this case, the user holds the handle 3 with a finger and presses the columnar pressing portion 1a against the perineum.

  It is desirable that the cylindrical pressing portion 1a in the example shown in FIGS. When the pressing portion 1a is rotatably attached to the handle portion 3, the user holds the handle portion 3 with a finger and keeps the cylindrical pressing portion 1a in contact with the skin of the perineum. By moving the handle part 3 along the skin, the pressing part 1a is rotated on the skin.

  The pressing part 1a in the example shown in FIGS. 1 to 3 is formed by attaching an elastomer surface part 7a to the outer surface of a cylindrical core member 5a. What is shown by the code | symbol 9 is the rotating shaft of the press part 1a.

  The pressing portion 1b in the example shown in FIGS. 4 and 5 is formed in a spherical shape and includes a handle portion 3. In this case, the user holds the handle 3 with a finger and presses the spherical pressing portion 1b against the perineum.

4 and 5, the pressing portion 1b is formed by attaching an elastomer surface portion 7b to the outer surface of a spherical core material 5b.

The pressing portion 1c in the example shown in FIGS. 6 and 7 is formed in a substantially rectangular parallelepiped shape and includes a handle portion 3. In this case, the user holds the handle 3 with a finger and presses the substantially rectangular parallelepiped pressing portion 1c against the perineum.

The pressing portion 1c in the example shown in FIGS. 6 and 7 is formed by attaching an elastomer surface portion 7c to the outer surface of a substantially rectangular parallelepiped core material 5c.

The pressing portion 1d in the examples shown in FIGS. 8 and 9 is formed in a substantially rectangular parallelepiped shape and does not include a handle portion. In this case, the user grips the rectangular parallelepiped pressing portion 1d with his hand and presses it against the perineum.

The pressing portion 1d in the example shown in FIGS. 8 and 9 is formed by attaching an elastomer surface portion 7d to the outer surface of a substantially rectangular parallelepiped core material 5d.

The pressing part 1e in the example shown in FIG. 10 is formed only of an elastomer.

  A cylindrical pressing portion (14 mm in diameter, 14 mm in length, and 4.6 g in weight) made of an elastomer having a flat surface with adhesiveness on the outer surface of the core material is made of synthetic resin. A urination-suppressing tool (weight 12 g) that was rotatably attached to the handle was prepared.

[test]
The effect of light skin stimulation by the urination inhibitor of Example 1 on bladder function was examined using anesthetized adult male rats.

[Test method]
Adult male rats were anesthetized and the core body temperature was maintained in the physiological range under artificial respiration. A polyethylene tube was inserted into the bladder from the bladder neck of the rat, and this was connected to a pressure transducer to measure the intravesical pressure. Saline was infused into the bladder to fill the bladder and induce urinary contraction movement of the bladder.

  The handle portion of the urination inhibitor was grasped, the pressing portion was brought into contact with the perineum portion of the rat, and the skin was stimulated for 1 minute by slowly rotating.

[Test results]
〇 Before giving a stimulus:
When physiological saline was injected into the bladder to increase the pressure inside the bladder, the bladder performed micturition contraction. Since the urethra was blocked by the polyethylene tube, the bladder contents were not excreted even when the bladder contracted, and the bladder repeated urination contraction with a large amplitude at a frequency of 1.5 to 2 times per minute.

* When a stimulus is given:
FIG. 11 shows changes in the intravesical pressure (unit: cmH ₂ O) when skin stimulation was performed for 1 minute (time indicated by reference sign “a” in FIG. 11) with the urination inhibitor of Example 1 as described above. As is clear from FIG. 11, urinary contraction movement of the bladder was suppressed by applying skin stimulation to the perineum using the urination suppressing tool of Example 1. The inhibitory effect of bladder urination contraction appeared from the start of skin stimulation and persisted for several minutes after the end of skin stimulation.

[Comparative Example 1]
A brush that gives non-nociceptive stimuli was used as a urinary suppression device.

[test]
The effect of brushing stimulation by the brush of Comparative Example 1 on bladder function was examined using anesthetized adult male rats.

[Test method]
In the same manner as in Example 1, adult male rats were anesthetized, and the deep body temperature was maintained within the physiological range under artificial respiration. A polyethylene tube was inserted into the bladder from the bladder neck of the rat, and this was connected to a pressure transducer to measure the intravesical pressure. Saline was infused into the bladder to fill the bladder and induce urinary contraction movement of the bladder.

  The rat's perineum was brushed for 1 minute with the brush of Comparative Example 1.

[Test results]
〇 Before giving a stimulus:
The same as in the first embodiment.

* When a stimulus is given:
FIG. 12 shows the change in the intravesical pressure (unit: cmH ₂ O) when the brushing stimulation of Comparative Example 1 was performed for 1 minute (the time indicated by symbol b in FIG. 12) for brushing stimulation as described above. As is clear from FIG. 12, even when brushing stimulation was applied to the perineum using the writing brush of Comparative Example 1, the effect of suppressing bladder urination contraction was hardly observed.

[Discussion]
From the above results, it was revealed that slight skin irritation by the urination-suppressing device of Example 1 suppresses urinary contraction movement of the bladder in rats. Therefore, the possibility that the slight skin irritation by the urination inhibitor of Example 1 is effective for the treatment of overactive bladder or urinary incontinence in humans is expected.

  Conventionally, bladder urinary contraction in rats has been reported to be suppressed when nociceptive stimulation is applied to the perineal skin, but is hardly affected by non-nociceptive stimulation to the perineal skin (Sato et al. Brain Research 94: 465-474, 1975). In the above test as well, it was revealed that non-nociceptive stimulation with a brush on the perineum of the rat had little effect of suppressing bladder contraction exercise.

  On the other hand, it became clear for the first time that the slight skin stimulation by the urination-suppressing device of Example 1 had a remarkable suppression effect comparable to the nociceptive stimulation of the skin against the urinary contraction of the bladder in rats. . Since the skin irritation by the urination inhibitor of Example 1 is not invasive, it is suitable for clinical application to humans.

DESCRIPTION OF SYMBOLS 1 Press part 1a Press part 1b Press part 1c Press part 1d Press part 1d Press part 1e Press part 3 Handle part 5a Core material 5b Core material 5c Core material 5d Core material 7a Surface part 7b Surface part 7c Surface part 7d Surface part 9 Rotating shaft

Claims (2)

Have adhesive, and a pressing portion formed by a flexible elastic body having a flat surface, and so as to suppress the micturition contraction movement of the bladder by pressing the human body perineum by pressing portion urination In the suppressor,
The urination suppressor , wherein the pressing portion is formed in a columnar shape and includes a handle portion . The urination inhibitor according to claim 1, wherein the pressing portion is rotatably attached to the handle portion .

Images