JP5613702B2 - Blister - Google Patents

Description

  The present invention relates to a blister incorporated into an inhalation-type dispenser.

  For asthma patients and the like, an inhalation-type dispenser that is convenient to carry is used. Patent Document 1 discloses an inhalation-type dispenser (drug administration device). This inhalation-type dispenser incorporates a blister containing a powder medicine. During the administration of the powder medicine, the blister is punctured and the inhalation flow generated by inhalation is guided into the blister, whereby the powder medicine is aspirated and dispensed to the patient.

Japanese Patent Publication No. 5-77433

  In the inhalation-type dispensing device described above, the following points have not been considered. The general particle size of the powder drug contained in the blister is several hundred μm to several μm. That is, since the powder medicine is fine particles, the fluidity of the powder medicine is low, the powder medicine is easily solidified, and is easily adhered to the blister. This type of inhalation-type dispenser is a drug that suppresses the symptoms of asthma, and the drug effect cannot be sufficiently expected without a prescribed amount of suction. In particular, since the suction input is weak in children and elderly people, it has been difficult to realize a prescribed amount of suction.

  An object of the present invention is to obtain a blister that can inhale the powder medicine contained in the blister more reliably without remaining in the blister, and that can realize downsizing or cost reduction.

The present invention includes a sealing material and a base material encapsulating a powder medicine and attached to the sealing material, and faces a generation site of a suction hole that sucks the fluid of the sealing material around the area where the outflow hole is generated The base material is provided with an annular projecting portion projecting inwardly containing the powdered drug, and an annular step formed on the suction hole side from the projecting portion, at an inner portion of the suction hole. To do.

  Moreover, the blister of the present invention is formed in a tape shape and is wound around a reel portion provided in an inhalation-type dispenser.

According to the present invention, the base is provided with an annular protrusion and a step , and the protrusion and the step can generate a turbulent flow in the fluid flowing from the suction hole generated in the sealing material. The encapsulated powder drug can be inhaled more reliably without stirring and remaining. Furthermore, since only the simple structure which produces | generates a cyclic | annular protrusion part and a level | step difference is added to the base material, at least any one of size reduction or cost reduction is realizable.

  In addition, according to the present invention, the blister is formed in a tape shape and wound around a reel portion provided in the inhaler / administrator, so that the blister can be easily handled.

(A) is a schematic front view showing the internal structure of the inhalation-type dosing device to which the blister according to the first embodiment of the present invention is attached, and (B) is seen from the direction of arrow 1B of the inhalation-type dosing device shown in (A). A schematic bottom view, (C) is a schematic side view of the inhalation-type dispenser shown in (A) as seen from the direction of arrow 1C. (A) is a schematic front view showing the external structure of the inhalation-type dosing device shown in FIG. 1, (B) is a schematic bottom view of the inhalation-type dosing device shown in (A) seen from the direction of arrow 2B, and (C) is ( It is the schematic side view seen from the arrow 2C direction of the inhalation-type prescription device shown to A). (A) is a front view of the blister before use attached to the inhalation-type dosing device shown in FIG. 1, and (B) is a side view of the blister shown in (A). It is a top view of the blister tape attached to the inhalation-type dosing device shown in FIG. FIG. 3 is an enlarged cross-sectional view of a main part showing a generation state of an outflow hole and an inhalation hole by a hole generation mechanism in the inhalation-type prescription device shown in FIG. (A) is a front view of a blister after use (or at the time of generating a hole) attached to the inhalation-type dispenser shown in FIG. 1, (B) is a side view of the blister shown in (A), and (C) is (A). It is a rear view of the blister shown in FIG. It is a side view which shows the flow of the fluid of the blister shown in FIG.6 (B). It is a rear view after use (or at the time of hole generation) of a blister concerning a 2nd embodiment of the present invention.

  Embodiments of the present invention will be described below with reference to the drawings. The present embodiment is an example in which the present invention is applied to a blister used in an inhalation-type dispenser that can be carried by an asthmatic patient. Note that, in the embodiments, the same components are denoted by the same reference numerals, and redundant description among the embodiments is omitted.

  (First Embodiment) [Configuration of Inhalation-Type Dispenser] As shown in FIGS. 1 (A) to 1 (C) and FIGS. 2 (A) to 2 (C), the first embodiment of the present invention is used. The inhalation-type dispensing device 1 to which the blister is attached includes a mill part 5, a positioning mechanism 3 for positioning the blister 40 containing the powder medicine in the mill part 5, and the powder medicine contained in the blister 40 to be positioned. A hole generating mechanism 7 that generates an outflow hole (see FIG. 6, reference numeral 421) that flows out to the mill unit 5 and a suction hole (see FIG. 6, reference numeral 412) that sucks fluid into the outflow hole is provided around it. .

  The housing 2 of the inhalation-type dispensing device 1 has, for example, a length of 110 mm-120 mm, a width of 68 mm-70 mm, and a thickness of 38 mm-40 mm, and is configured with a portable and compact size. The housing 2 is made of a resin that is advantageous for ease of molding and cost reduction.

  The mill part 5 of the inhalation-type dispenser 1 is disposed in the central portion of the housing 2, and one end on the lower side of the mill part 5 shown in FIGS. 1 (A) and 1 (B) is communicated with the mouthpiece 6. Yes. The powder medicine contained in the blister 40 is discharged and dispersed in the mill unit 5. The mouthpiece 6 is a place where the asthma patient directly inhales the lips, and the powder medicine that has flowed out to the mill unit 5 is sucked into the asthma patient through the mouthpiece 6.

  The blister 40 is attached to the inhalation-type dispenser 1. As shown in FIGS. 3A and 3B, the blister 40 includes a film-like sealing material 41 and a base material 42 attached to the sealing material 41. The base material 42 is provided with an inner portion 42A that is projected and molded and can enclose a powder medicine in a space inside thereof. Here, the powder drug is used to mean a powder drug for treating asthma symptoms in asthmatic patients. For example, an aluminum foil is used for the sealing material 41. For the base material 42 and the inner packet part 42A integrally molded therewith, for example, a transparent resin, specifically, PVC, an aluminum sheet or the like can be used practically.

  In the first embodiment, as shown in FIG. 4, a blister tape 4 is used in which a plurality of blisters 40 are integrally formed in one direction (here, the left-right direction in the figure). A certain amount of powdered medicine used in a single dose is contained in the internal portion 42A of one blister 40 of the blister tape 4. For example, the blister tape 4 has a configuration in which 30 blisters 40 each containing 20 mg of the powder medicine can be connected, that is, 20 mg of the powder medicine can be dispensed 30 times.

  In the first embodiment, as shown in FIG. 4, the inner packet part 42 </ b> A is disposed on the lower side in the drawing from the center axis in the width direction of the sealing material 41. The inner packet part 42 </ b> A is arranged at a constant pitch in the longitudinal direction of the sealing material 41. On the other hand, a guide hole 43 for conveying and positioning the blister tape 4 along the longitudinal direction of the sealing material 41 is provided above the center in the width direction of the sealing material 41.

  As shown in FIGS. 1 (A) and 1 (B), inside the housing 2, a supply reel 32 that rotates about a rotating shaft 31 on the left side of the mill portion 5 and a rotating shaft on the right side thereof. A collection reel 34 that rotates about 33 is disposed. The supply reel 32 is wound around one end of the blister tape 4 including the blister 40 before use, that is, before using the powder medicine. The other end of the blister tape 4 including the blister 40 after use, that is, after using the powder medicine, is wound around the collection reel 34. A part 34A (the right end in FIGS. 1A, 1B, 2A, and 2B) of the collection reel 34 slightly protrudes from the housing 2, and this part 34A is The blister tape 4 can be collected on the collection reel 34 by rotating manually. Of course, the blister tape 4 is recovered by rotating the recovery reel 34, but the supply reel 32 is also rotated in conjunction with it, and the blister tape 4 is supplied from the supply reel 32.

  The blister tape 4 is supplied from the supply reel 32 and guided to the guide 35. The inner packet part 42 </ b> A of one blister 40 of the blister tape 4 is positioned on the other end side of the mill part 5. When the inner packet part 42A is positioned, the inner packet part 42A is once locked. Locking is performed each time the inner packet part 42A of one blister 40 of the blister tape 4 is positioned on the mill part 5. Further, the lock is released by the hole making operation of the hole generating mechanism 7.

  Although the detailed structure of the positioning mechanism 3 of the inhalation-type dispensing device 1 is omitted, as shown in FIGS. 1 (A) to 1 (C), a transport mechanism having a supply reel 32, a guide 35, and a recovery reel 34. And means for positioning and locking the inner packet part 42A of one blister 40 of the blister tape 4 on the mill part 5 and means for releasing the lock. Further, the positioning mechanism 3 has a counter mechanism for rotating the remaining number display counter 36 in accordance with the collection amount of the blister tape 4 collected along with the rotation of the collection reel 34 and displaying the remaining number of unused blisters 40. I have. The remaining number displayed by the remaining number display counter 36 can be confirmed from the display window 21 provided in the housing 2 shown in FIG. Similarly, the remaining number is indicated by an arrow 22 marked on the housing 2.

  As shown in FIGS. 1 (A), 1 (C), 5, 6 (A), 6 (B) and 6 (C), the hole generating mechanism 7 of the inhalation-type dispenser 1 is a blister. 40 in the central portion of the inner packet part 42A, a suction hole 411 for the fluid in the sealing material 41 and an outflow hole generating needle 75 for generating an outlet hole 421 for the powder medicine in the base material 42; A suction hole generating needle 76 for generating a fluid suction hole 412, a pressing hole 71 connected to the outflow hole generating needle 75 and the suction hole generating needle 76, a guide 73 for guiding the sliding of the pressing part 71, and a pressing part 71 And an elastic body 72 that pushes up the pressing portion 71 against the pressing operation.

  In the first embodiment, first, the inner packet part 42A of the blister 40 is formed in a shape close to a hemisphere, and the planar shape of the outflow hole 421 and the suction hole 411 generated in the central part of the inner packet part 42A is a circle. A plurality of suction holes 412 generated in the peripheral portion of the inner packet part 42A are arranged at equal intervals around the outflow hole 421. The planar shape of the suction hole 412 is a circle like the outflow hole 421, and the diameter of the suction hole 412 is set smaller than the diameter of the outflow hole 421 here. Note that the planar shapes of the outflow holes 421 and the suction holes 411 and 412 are not necessarily limited to circles, and the shapes can be appropriately changed. For example, the planar shape of each of the outflow hole 421 and the suction holes 411 and 412 can be appropriately changed as necessary, such as an ellipse, a rectangle, or a pentagon or more polygon. In the first embodiment, the outflow hole generation needle 75 and the suction hole generation needle 76 are formed of a metal such as stainless steel, a hard resin, or the like, and the outflow hole generation needle 75 and the suction hole generation needle 76 are integrally formed. Yes. Furthermore, in the first embodiment, the pressing portion 71 is configured integrally with the outflow hole generating needle 75 and the suction hole generating needle 76. For example, a coil spring can be used practically for the elastic body 72. The guide 73 is configured using a part of the housing 2, and guides the moving direction F of the outflow hole generating needle 75 in the generation operation of the outflow hole 421 of the blister 40, thereby generating the suction hole 412 of the blister 40. In the operation, the moving direction F of the suction hole generating needle 76 is guided.

Here, as shown in FIGS. 3, 5, 6 (B) and 7, the fluid of the sealing material 41 is sucked into the periphery where the outflow hole 421 is generated in the inner packet part 42 </ b> A of the blister 40 of the blister tape 4. An annular step 423 is disposed on the base material 42 so as to face the generation site of the suction hole 412 to be formed. The step 423 is disposed at a position corresponding to the suction hole generating needle 76 and has a shape having an arc inside the inner packet part 42A. More specifically, the inner packet part 42A has a structure in which a hemisphere having a step 423 and a hemisphere stacked on top of each other and a hemisphere smaller than the former are overlapped. Further, an annular projecting portion 423A projecting inwardly containing the powdered drug is provided on the inner side of the suction hole 412 of the base material 42 facing the generation site of the suction hole 412. The protruding portion 423A is formed as an arc shape to the outflow hole 42 1 side than the stepped difference 423. Here, the fluid is air generated when the asthma patient sucks from the mouthpiece 6 in order to administer the powder medicine. That is, the fluid generated by suction and flowing from the suction hole 412 of the sealing material 41 becomes turbulent in the protrusion 423A connected to the step 423, and the sealing material 41 and the base material 42 are attached to each other by the turbulent flow generated by the protrusion 423A. It is possible to agitate the powder medicine existing along the portion and efficiently discharge the powder medicine from the outflow hole 421 to the mill unit 5 without leaving any excess.

  [Method of operating the inhalation-type dispenser] The operation procedure of the inhalation-type dispenser 1 shown in FIGS. 1 to 7 is as follows. First, as shown in FIG. 1B, a part 34A of the recovery reel 34 protruding from the housing 2 of the inhalation-type prescription device 1 is rotated until it is locked in the arrow direction (counterclockwise). As the collection reel 34 rotates, the supply reel 32 rotates in the direction of the arrow (clockwise) and the blister tape 4 is supplied to the mill unit 5. The blister tape 4 is guided by the guide 35 and supplied to the mill unit 5. When the collection reel 34 rotates by a certain amount, the positioning mechanism 3 positions the unused blister 40 on the mill portion 5, and the blister 40 is locked at this position.

  The pressing portion 71 of the hole generating mechanism 7 is pressed against the elastic force of the elastic body 72, and the outflow hole generating needle 75 connected to the pressing portion 71 is positioned and locked in the enclosing portion 42 </ b> A of the blister 40. The suction hole 411 is generated in the base plate 42, and the outflow hole 421 is generated in the base member 42 (see FIG. 5). Subsequently, the suction hole generating needle 76 generates a suction hole 412 in the sealing material 41 in the inner packet part 42A of the blister 40 that is positioned and locked. When the operation for generating the outflow hole 421 and the suction hole 412 is started, the recovery reel 34 is unlocked. When the pressing portion 71 is returned to the original position by the elastic force of the elastic body 72, the outflow hole 421 and the suction holes 411 and 412 open in the inner packet portion 42A of the blister 40.

The operator holds the mouthpiece 6 of the inhalation-type dispenser 1 and starts aspiration. By this operation, the powder medicine contained in the inclusion part 42 </ b> A of the blister 40 is discharged to the mill part 5 through the outflow hole 421. Here, in the inner packet part 42A of the blister 40, a suction hole 412 is disposed around the outflow hole 421, and the fluid sucked into the suction hole 412 flows into the outflow hole 421 along the inner wall of the inner packet part 42A. Since the path can be generated, the outflow of the powder medicine remaining on the inner wall of the inner packet part 42A can be promoted. Furthermore, the sheathing portion 42A of the blister 40, the substrate 42 facing the suction hole 412, the inner portion of the suction hole 412, a protruding portion 423A of the annular projecting inwards that powdered medicament is contained, the protrusion 423A Since the annular step 423 is disposed closer to the suction hole 412, the fluid sucked into the suction hole 412 becomes a turbulent flow between the step 423 and the protruding portion 423A , stirs the powder medicine, and includes the inclusion portion. in the inner wall of 42A improves the flowability of the powdered medicament, interfere with solidification, and can be prevented from adhering.

  According to the inhalation-type dispensing device 1 configured as described above, the powder medicine contained in the blister 40 is reliably left from the outflow hole 421 of the blister 40 without remaining in the blister 40 by the fluid sucked from the suction hole 412. Can be dosed. Furthermore, since the hole generating mechanism 7 is simply added to the blister 40 with a simple structure for generating the suction hole 412 in addition to the structure for generating the outflow hole 421, at least one of miniaturization and cost reduction can be realized. Can do.

On the other hand, in the blister 40 (blister tape 4) according to the first embodiment, the base 42 is provided with an annular step 423 and a protruding portion 423A, and the step 423 and the protruding portion 423A are generated in the sealing material 41. Since a turbulent flow can be generated in the fluid flowing in from 412, the powder medicine contained in the blister 40 can be reliably dispensed without stirring and remaining. Furthermore, since only the simple structure which produces | generates the cyclic | annular level | step difference 423 and protrusion part 423A is added to the base material 42, the blister 40 (blister tape 4) which can implement | achieve at least any one of size reduction or cost reduction. Can be provided.

  (Second Embodiment) The second embodiment of the present invention is to explain a modification of the blister 40 (blister tape 4) according to the first embodiment described above. In the hole generating mechanism 7 of the inhalation-type dispenser 1 according to the second embodiment, as shown in FIG. 8, a planar shape C-shaped inhalation hole 412 is formed in the sealing material 41 in the peripheral portion of the inner packet part 42 </ b> A of the blister 40. It is arranged. The suction holes 412 are arranged at two places in the upper and lower portions around the outflow hole 421 in the drawing. The suction holes 412 are formed by continuously arranging suction holes having a circular plane shape on a concentric circle with the central axis as a center. Although not shown, the suction hole generation needle 76 of the hole generation mechanism 7 is configured in a shape that can generate such a suction hole 412.

  The present invention is not limited to the embodiment described above. For example, in the blister 40 (blister tape 4) according to the first embodiment described above, a total of eight suction holes 412 are disposed around the outflow hole 421 in the inner packet part 42A, but this number is limited. In the present invention, a natural number of suction holes 412 other than eight may be provided.

  The present invention can be used for a blister attached to an inhalation-type dispenser.

DESCRIPTION OF SYMBOLS 1 Inhalation-type prescription device 3 Positioning mechanism 40 Blister 41 Seal material 42 Base material 411, 412 Inhalation hole 421 Outflow hole 423 Level difference
423A Protruding part 42A Inner part 5 Mill part 7 Hole generating mechanism

Claims (2)

Sealing material,
A base material encapsulating a powder medicine and pasted to the sealing material,
Around the outlet hole is generated in the substrate which faces the generation point of suction holes for sucking a fluid of the sealing material, the inside portion of the suction hole, the projecting annular projecting inwards that powdered medicament is contained A blister comprising a portion and an annular step formed closer to the suction hole than the protruding portion . The blister of claim 1, wherein
The blister is formed in a tape shape, characteristics and to Lube lister to be wound on the reel unit provided in an inhaling type medicine administering device.

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