JP5596476B2 - Drive device for needleless syringe and drive method for drive device for needleless syringe - Google Patents

Description

  The present invention relates to a drive device for a needleless syringe and a drive method for the drive device for a needleless syringe used for subcutaneous injection such as insulin injection for diabetes and placenta injection for cosmetic surgery.

  A needleless syringe contains a drug solution in a syringe with a minute nozzle at the tip, and a plunger is slidably provided in the syringe. At the time of medication, a spring-type drive is attached to the proximal end of the syringe. Is done. This spring-type drive device uses a spring energy to press a plunger to eject a chemical solution from a nozzle applied to the skin. (For example, Patent Documents 1 and 2).

  By the way, as a research result on the diffusion of the drug solution injected without needle into the skin, the time until the drug solution penetrates the skin depends on the gap between the piston and the plunger in the spring case. That is, by having a gap between the piston and the plunger, the piston biased by the spring force gives an impact force to the plunger side, and the requirement that the drug solution diffuses in the skin by this impact force is important. It has been found. (For example, non-patent documents 1 and 2).

Special table 2007-533342 gazette JP-A-4-51966

Satoshi Hashimoto: Effect of moving part equivalent mass on injection characteristics of needleless syringe (2009.3) Hiroto Konishi: Prototype of needleless syringe capable of split injection, Proceedings of the 2008 Annual Meeting of the Japan Society of Mechanical Engineers, Vol.2, pp19-20 (2008.8)

  In the prior art, a chemical solution can be administered only once for each filling of the chemical solution, and the syringe is disposable for each injection. Therefore, a plurality of syringes must be carried when going out for a long time or for a long time. Moreover, since it is necessary to prevent air from entering the syringe for every filling of the chemical solution, careful work is required. Furthermore, a strong force is required for the compression of the spring, and performing it for each injection was a complicated operation.

  Further, in the administration of a drug solution by a needleless syringe, it is important that an impact force is applied to the plunger side by the piston as described above, and the drug solution is diffused in the skin by this impact force.

  The problem to be solved is that injection can be divided into several times and administered by a single liquid filling and spring force charge (load). In addition, even in such divided administration, an impact force can be applied to the plunger side by a piston during each administration.

According to the first aspect of the present invention, there is provided a machine frame body for attaching a syringe of a needleless syringe provided with a nozzle at the front end and a plunger slidably attached to the front part, and provided on the machine frame body so as to face the plunger. A piston that is movably provided on the front side and that can press the plunger, and a spring that is provided on the main body of the machine and presses the piston forward. The compressed spring is extended to advance the piston. In the drive device for the needleless syringe that presses the plunger,
The spring is provided on a spring holding member, and a detachable spring holding member / piston connecting means is interposed between the spring holding member and the piston, and the spring holding member is attached to the machine frame main body. A needleless syringe drive device comprising a machine frame main body / spring holding member connecting means which is slidably provided rearward and which is detachable between the machine frame main body and the spring holding member. .

  According to a second aspect of the present invention, a plurality of piston stoppers for the piston are provided in the machine body, and the piston stoppers are provided corresponding to the advancing direction of the piston, and the piston is selectively used for the plurality of piston stoppers. The needleless syringe drive device according to claim 1, wherein the drive device corresponds to a stop.

  The invention according to claim 3 is characterized in that an operating body is provided on the machine body, and the operating body is provided with a spring holding member retreat connection means that can be attached to and detached from the spring holding member. It is a drive device of a needleless syringe.

  According to a fourth aspect of the present invention, the spring holding member / piston connecting means is provided with a trigger for a medication operation on the machine frame body, and a plurality of trigger locks capable of locking the trigger to a piston extension member integrated with the piston. The needleless syringe drive device according to claim 3, wherein a receiving portion is provided, and the trigger is selectively locked to the plurality of trigger locking receiving portions.

  According to a fifth aspect of the present invention, the machine frame main body / spring holding member connecting means is provided with a hook on the machine frame main body, and provided with a plurality of hook locking receiving portions to which the hook can be locked on the spring holding member, 5. The needleless syringe driving apparatus according to claim 4, wherein the hook is selectively locked to the plurality of hook locking receiving portions.

  The invention of claim 6 is characterized in that the plurality of piston stoppers are arranged in a movement path of piston protrusions provided on the piston, and the piston protrusions are selectively locked. It is a drive device of a needle syringe.

  The invention according to claim 7 is characterized in that the operating body is provided with an activation part of the spring holding member / piston connection means and a drive part of the machine frame main body / spring holding member connection means. 3. A drive device for a needleless syringe according to 3.

  The invention according to claim 8 is the drive device for the needleless syringe according to claim 7, wherein the operating body includes a grip portion and is slidably provided on the machine body.

  The invention according to claim 9 is a machine frame body for attaching a syringe of a needleless syringe provided with a nozzle at the front end and a plunger slidably attached to the front part, and provided on the machine frame body so as to face the plunger. A piston that is movably provided on the front side and that can press the plunger, and a spring that is provided on the main body of the machine and presses the piston forward. The compressed spring is extended to advance the piston. In the driving method of the needleless syringe driving device that presses the plunger, the spring is partially extended by a part of the elastic force of the compressed spring, and the piston is advanced to collide with the plunger. Then, after the spring is retracted together with the piston to form an impact gap between the plunger and the piston, the spring remaining again A driving method of the needle-free syringe driving apparatus characterized by by stretching the spring by resilient by advancing the piston to collide with the plunger.

  A tenth aspect of the present invention is the method for driving a needleless syringe driving apparatus according to the ninth aspect, wherein the spring is repeatedly retracted together with the piston to cause the piston to collide with the plunger a plurality of times.

According to the first aspect of the present invention, since the gap for impact can be formed in advance between the piston and the plunger in advance, the drug solution can be dispersed and administered. For example, after compressing a spring once, a piston can be advanced intermittently and a chemical | medical solution can be administered.

  According to the invention of claim 3, by operating the operating body, the spring holding member can be moved backward to form the gap.

  According to the invention of claim 4, it is possible to reliably dispense by selectively locking the trigger to the trigger locking receiving portion.

  According to the fifth aspect of the present invention, the gap can be reliably secured by selectively locking the hook to the hook locking receiving portion.

  According to the sixth aspect of the present invention, the piston can be stopped directly by the piston stopper to prevent malfunction.

  According to the invention of claim 7, the spring holding member / piston connecting means and the machine frame main body / spring holding member connecting means can be operated by the operating body.

  According to invention of Claim 8, operation can be easily performed by the back-and-forth movement of the operation body.

  According to the invention of claim 9, it is necessary to compress the spring for each dosage by retracting the spring holding member and extending the spring by the elasticity of the remaining spring to advance the piston and collide with the plunger. There are no divided doses.

  According to the invention of claim 10, a plurality of divided doses can be performed.

It is the schematic which shows the preparation process which shows Example 1 of this invention. It is the schematic which shows the 1st process. It is the schematic which shows the 2nd process. It is the schematic which shows the 3rd process. It is the schematic which shows the 4th process. It is the schematic which shows the 5th process. It is the schematic which shows the 6th process. It is the schematic which shows the 7th process. It is the schematic which shows the 8th process. It is a whole longitudinal cross-sectional view of the initial state. It is the whole plane sectional view of the initial state. It is a whole longitudinal cross-sectional view of the 1st process. It is a whole plane sectional view of the 1st process. It is a whole longitudinal cross-sectional view of the 2nd process. It is a whole plane sectional view of the 2nd stroke. It is a whole longitudinal cross-sectional view of the 3rd process. It is a whole plane sectional view of the 3rd stroke. It is a whole longitudinal cross-sectional view of the 4th process. It is a whole plane sectional view of the same 4th stroke. It is a whole longitudinal cross-sectional view of the said 7th process. It is a partial notch whole top view of the 7th stroke. It is a whole longitudinal cross-sectional view of the 8th process. It is a whole plane sectional view of the 8th stroke. It is a disassembled perspective view of the whole. It is a disassembled perspective view of the forward movement-rotation movement conversion mechanism. It is a perspective view of the 1st process of the forward movement-rotation movement conversion mechanism. It is a perspective view of the 2nd stroke of the forward movement-rotation movement conversion mechanism. It is a perspective view of the 3rd process of the forward movement-rotation movement conversion mechanism. It is a perspective view of the 4th stroke of the forward movement-rotation movement conversion mechanism. It is a perspective view of the 5th stroke of the forward movement-rotation movement conversion mechanism. It is a perspective view of the 6th stroke of the forward movement-rotation movement conversion mechanism. It is a perspective view of the 7th stroke of the forward movement-rotation movement conversion mechanism. It is a perspective view of the 8th stroke of the forward movement-rotation movement conversion mechanism. It is a plane sectional view of the 1st stroke of the spring holding member retreat connection means. It is a plane sectional view of the 2nd stroke of the spring holding member retreat connection means. It is a top sectional view of the 3rd stroke of the spring holding member retreat connection means. It is a front view of the 1st process of the same machine frame main part and a spring holding member connection means. It is a front view of the 2nd process of the machine frame main body and a spring holding member connection means. It is a front view of the 3rd process of the same machine frame main part and a spring holding member connection means. It is a front view of the 4th process of the same machine frame main part and a spring holding member connection means. It is a front view of the 5th process of the same machine frame main part and a spring holding member connection means. It is a front view of the 6th process of the same machine frame main part and a spring holding member connection means. It is a perspective view which shows Example 2 of this invention.

  Preferred embodiments of the present invention will be described with reference to the accompanying drawings. The embodiments described below do not limit the contents of the present invention described in the claims. In addition, all of the configurations described below are not necessarily essential requirements of the present invention.

  The drive device 2 of the needleless syringe 1 according to the first embodiment shown in FIGS. 1 to 42 is used, for example, for insulin injection. The insulin injection is usually performed three times at breakfast, lunch, and dinner per day. Since it is to be performed, it shows what can be injected three times. In actuality, after the syringe 3 is mounted, the plunger 4 in the syringe 3 needs to be slightly pressed first to release the air in the syringe 3, so the number of times the plunger 4 is pressed is The first stroke A from the initial position of the plunger 4 for the first stroke, the second stroke B after the first stroke A to be the first dose, and the second stroke B to be the second dose The third stroke C from 4 and the fourth stroke D after the third stroke C for the third dose are shown.

  In the needleless syringe 1, a nozzle 5 is provided at the front end of a cylindrical syringe 3 containing a chemical solution (not shown), and a plunger 4 projects slidably at a rear end 3 </ b> B of the syringe 3. The case main body 6 which is a machine frame main body of the driving device 2 to which the rear end 3B of the syringe 3 is connected has a cylindrical shape, and a mounting hole 7 for the syringe 3 is provided on the surface of the front end 6F. The plunger 4 passes through the hole 7. Further, the rear end 6B of the case body 6 is opened so that a spring case 8 described later can be projected and retracted. Further, the front left and right window holes 11 and the left and right surfaces of the case body 6 are formed to form a movement path of a piston projection 10 to be described later on the left and right of the front portion of the circumferential surface provided along the central axis 9 of the case body 6. Rear left and right window holes 12 (shown in the lower part of the case body 6 for the sake of illustration in FIGS. 1 to 9), orthogonal to the left and right direction of the rear part of the peripheral surface, while the rear upper window holes are on the upper surface in the figure. 13 are respectively formed along the central axis 9.

  In the case main body 6, a piston 14 is provided on the central axis 9 of the case main body 6, which can slide along the central axis 9 to press the rear end 4 </ b> B of the plunger 4. 14 has a disk shape whose pressing surface is perpendicular to the central axis 9, and a spring, in the embodiment, a coil spring 15 is provided behind the piston 14, and this coil spring 15 causes the piston 14, and hence the plunger 4 to be moved. It can be pushed forward.

  A spring case 8 as a spring holding member that houses the coil spring 15 is built in the rear portion of the case body 6. The spring case 8 has a cylindrical shape coaxial with the central axis 9, and an outer peripheral surface thereof can slide on the inner peripheral surface of the case body 6, and a part of the upper portion of the outer peripheral surface is a rear portion. It faces the upper surface window hole 13 and part of the left and right portions of the outer peripheral surface faces the rear left and right window holes 12. The front end 8F of the spring case 8 is open, and the rear end 8B is closed by a rear plate portion so that the rear end 15B of the coil spring 15 is in contact with and fixed. In the embodiment, the total length of the spring case 8 in the direction of the central axis 9 is formed to be approximately half the total length of the case body 6.

  Further, a trigger 16 that is a trigger for pressing the plunger 4 against the piston 14 is provided on the upper portion of the spring case 8. The trigger 16 is mounted on the front side of the spring case 8 so as to always appear in the rear upper surface window hole 13, and the rear portion 16B faces inward (center axis 9 side) and the front portion 16F faces outward (center axis). The intermediate portion is provided so as to be undulated via a first shaft 18 whose longitudinal direction is perpendicular to the central axis 9. Then, trigger locking receiving portions 19, 20, 21, and 22 that are selectively locked by the trigger 16 are provided integrally with the piston 14. The latch receiving portions 19, 20, 21, and 22 are provided by forming a hole in the piston extension member 23 that extends rearward of the piston 14, and the piston extension member 23 is provided on the outside of the piston 14 with an upper surface window hole. Trigger lock receiving portions 19, 20, 21, and 22 that are integrally provided so as to face the rear 13 are first trigger lock receivers that the trigger 16 locks before the first dose. Portion 19, similarly, the second trigger lock receiving portion 20, the third trigger lock receiving portion 21, and the fourth trigger lock receiving portion 22 that the trigger 16 locks before the first to third injections. These first to fourth trigger lock receiving portions 19, 20, 21, and 22 are arranged at an interval from the rear portion to the front portion of the piston extension member 23 provided on the upper portion of the piston 14. Has been. The piston extension member 23 protrudes behind the piston 14, is slidably provided on the upper part of the inner peripheral surface of the spring case 8, and the inner side faces the coil spring 15. A trigger 16 that rotates in the undulation direction on the spring case 8, a first trigger lock receiving portion 19 that is provided on a piston extension member 23 to which the piston 14 is connected, and that the trigger 16 selectively locks, is provided. The spring case 8 and the piston 14 are selected between the spring case 8 and the piston 14 by the trigger lock receiving portion 20, the third trigger lock receiving portion 21, and the fourth trigger lock receiving portion 22. A spring holding member / piston connection means 24 is provided which is detachably connected so as to be fixed or non-fixed.

  In addition, piston stoppers 28, 29, 30, 31 for the piston 14 are provided at the front of the case body 6 to stop the piston 14 in correspondence with the strokes A, B, C, D. The piston stoppers 28, 29, 30, 31 of the piston 14 are formed by a short cylindrical piston stopper ring 26 that is rotatably fitted to the front portion of the case body 6 in the same manner as the central axis 9. The front end 26F is rotatably locked to the front side plate 27 of the case body 6. On the other hand, at the rear end 26B of the piston stopper ring 26, there is a first piston stopper 28 for stopping the piston 14 in correspondence with the first stroke A from the initial state, and a second stroke B following the first stroke A. The second piston stopper 29 that stops in response to the third stroke C, the third piston stopper 30 that stops in response to the third stroke C that follows the second stroke B, and the fourth stroke D that follows the third stroke C 4 is provided with a fourth piston stopper 31 that stops in response to the piston protrusion 10 projecting outwardly on the outer periphery of the piston 14 and has the following length relationship. Have The length from the front end of the piston stopper ring 26 to the first piston stopper 28 is the first length E, similarly the front end to the second piston stopper 29, the front plate 27 to the third piston stopper 30, and the front end to the first length E. When the length up to 4 piston stoppers 31 is the second length F, the third length G, and the fourth length H, the first length E, the second length F, the third length The length G is shortened in the order of the fourth length H, and the difference between the first length E and the second length F is equal to the second stroke B. Similarly, the second length The difference between the length F and the third length G is equal to the third stroke C, and the difference between the third length G and the fourth length H is equal to the fourth stroke D. .

  The piston protrusions 10 are provided at two locations on the left and right. For this reason, the piston stoppers include a first piston stopper 28, a second piston stopper 29, a third piston stopper 30, a fourth piston stopper 31, and a first piston stopper. The piston stopper 28, the second piston stopper 29, the third piston stopper 30, and the fourth piston stopper 31 are arranged in an annular shape in an intermittent manner.

  The piston stoppers 28, 29, 30, and 31 can be manually rotated every time the medicine is dispensed to stop the piston 14 at a predetermined position. However, in the embodiment, an operating body that operates in the front-rear direction as will be described later. The piston stopper ring 26 can be automatically rotated every 1/8 rotation through the forward / backward movement-rotation movement converting means 33 in conjunction with the backward movement of 32. As a result, the piston protrusion 10 can be selectively locked to the first piston stopper 28, the second piston stopper 29, the third piston stopper 30, and the fourth piston stopper 31. The rotation angle of the piston stopper ring 26 is appropriately changed depending on the number of piston stoppers.

  The operating body 32 can hold the outer periphery with one hand, has a substantially cylindrical grip 32B coaxial with the central axis 9, and is the same as the central axis 9 so that the rear part of the case body 6 is externally fitted. It is provided in such a manner that it is linear and can reciprocate in the front-rear direction, and slides so that the spring case 8 slides in the left-right direction on the inner peripheral surface of the operating body 32 and the other perpendicular to the left-right direction. The sliding member 34 is provided. In addition, a small protrusion 32 </ b> A is provided on the inner peripheral surface of the operating body 32 as an activation part that presses the trigger 16.

  A spring holding member retracting connection means 35 as an impact gap securing means is interposed between the operating body 32 and the spring case 8. When the operating body 32 is moved rearward with respect to the case main body 6, the spring holding member retreat connection means 35 causes the spring case 8 to retreat with respect to the case main body 6 to perform the second to fourth administrations. In order to form the second gap J, the third gap K, and the fourth gap L, which are impact gaps, between the plunger 4 and the piston 14, respectively. A first gap I is formed in order to press the piston 14 against the plunger 4 in order to release air from the syringe 3. The second gap J, the third gap K, and the fourth gap L may be the same length. However, in order to keep the impact force constant, the second gap J is determined based on the spring constant of the coil spring 15 and the like. The third gap K and the fourth gap L may be sequentially increased. The second gap J is equal to the second stroke B, the difference between the first length E and the second length F, and the third gap K is the third stroke C, the second The fourth gap L is equal to the difference between the length F and the third length G, and the fourth stroke D, and the difference between the third length G and the fourth length H. .

  The spring holding member retreat connection means 35 is provided in a pair on the left and right sides of the operating body 32 and the left and right sides of the spring case 8. In addition, in schematic sectional drawing, it has shown in the lower side of the figure on description.

  The spring holding member retracting connection means 35 is provided with claw pieces 36 that rotate inward and outward on the inner peripheral surfaces of the left and right sides of the operating body 32. When the operating body 32 is retracted, the claw pieces 36 are By sequentially engaging with groove-like claw engagement receiving portions 37, 38, 39, 40 provided on the outer periphery of the left and right side surfaces of the spring case 8 through the rear left and right window holes 12, the spring case 8 and further the piston 14 can be moved backward together with the operating body 32. The claw piece 36 is pivotally provided on the operating body 32 through a second shaft 36 </ b> A whose axial direction is the vertical direction, and is pivotably provided. A sharp rear end 36 </ b> B is provided on the outer peripheral surface of the spring case 8. The claw piece 36 is urged by a spring 36S so as to be urged and pressed. On the other hand, on the left and right side surfaces of the spring case 8, a first claw piece engagement receiving portion 37 and a second claw piece engagement receptacle that can selectively engage the claw piece 36 from the rear end 8B to the front end 8F. A portion 38, a third claw piece locking receiving portion 39, and a fourth claw piece locking receiving portion 40 are provided at intervals. A claw piece 36 provided on the operating body 32, a first claw piece engagement receiving portion 37 provided on the spring case 8 and selectively engaged with the claw piece 36, a second claw piece engagement receiving portion 38, Only when the operating body 32 is moved rearward by the third claw piece locking receiving portion 39 and the fourth claw piece locking receiving portion 40, the spring case 8 is attached to the first claw piece engagement with the movement. The stopper portion 37, the second claw piece locking receiving portion 38, the third claw piece locking receiving portion 39, and the fourth claw piece locking receiving portion 40 can be sequentially retracted.

  Further, the machine frame main body / spring holding member connecting means which is a hook type holding means in which the spring case 8 retreated with respect to the case main body 6 by the spring holding member reverse connecting means 35 is detachably connected in that state and fixed. 41 will be described. A hook 42 is rotatably provided on the peripheral surface of the case body 6 on the rear end 6B side, and the hook 42 is provided in a lever shape via a third shaft 43 whose axial direction is the left-right direction. The front end 42F faces forward and faces inward, and the front end 42F of the hook 42 penetrates the rear upper surface window hole 13 and has groove-like hook locking receiving portions 44, 45, 46, 47 provided on the upper surface of the spring case 8. Is selectively locked. On the other hand, the rear portion of the hook 42 disposed behind the third shaft 43 faces outward. The hook 42 latching and receiving portion includes a first hook latching and receiving portion 44, a second hook latching and receiving portion 45, a third hook latching and receiving portion 46, from the rear side toward the front side along the central axis 9. Fourth hook locking receiving portions 47 are arranged at intervals. The hook 42 is provided with a spring 42S so that the front end 42F is always urged inward.

  In the embodiment, the operating body 32 is moved forward and backward with respect to the case main body 6 so that the hook 42 becomes the first hook locking receiving portion 44, the second hook locking receiving portion 45, and the third hook. The lock receiving portion 46 and the fourth hook lock receiving portion 47 can be automatically and sequentially locked. In this automated mechanism, a guide pin 48 is provided at the front end of the hook 42 so as to protrude from the left and right so as to be orthogonal to the central axis 9 in a separated state, and on the other hand, the rear side of the operating body 32 faces the guide pin 48. A hook guide claw piece 49 which is a drive unit is provided. The hook guide claw piece 49 is perpendicular to the central axis 9 in a separated state, and is provided so as to be rotatable in a undulation direction via a fourth shaft 50 disposed slightly outside the guide pin 48. The guide claw piece 49 is always urged by a spring 49S so that its rear end is directed inward in an oblique state. When the operating body 32 is advanced, the rear end 49B of the hook guide claw piece 49 is a guide. When the outer side of the pin 48 is overcome (FIGS. 37, 38, and 39) and the operating body 32 is subsequently retracted, the guide pin 48 integrated with the hook 42 that enters the first hook locking receiving portion 44 and is locked. And the front end 42F of the hook 42 is lifted (FIGS. 40 and 41), the hook 42 is released from the locked state with the first hook locking receiving portion 44, and the hook is moved further by the retraction of the operating body 32. 42 enters the second hook locking receiving portion 45 and engages. It comes to a stop state.

  The back-and-forth motion-rotation motion converting means 33 of the embodiment includes a piston stopper ring 26 that is rotatably fitted on the outer periphery of the front end 6F of the case body 6 and a rear portion of the piston stopper ring 26 as shown in FIGS. And a rotation driving ring 52 that is connected to the operating body 32 and rotates the piston stopper ring 26 every 1/8 rotation. The piston stopper ring 26 is divided into 1 to 2 equal parts, 3 to 4 equal parts, and 5 to 6 equal parts when the cylindrical part that is rotatably fitted to the outer periphery of the case body 6 is equally divided into 16 parts in the circumferential direction. 1st piston stopper 28 corresponding to the rear end of the part, 7-8 equal parts, 9-10 equal parts, 11-12 equal parts, 13-14 equal parts, 15-16 equal parts, A second piston stopper 29, a third piston stopper 30, a fourth piston stopper 31, a first piston stopper 28, a second piston stopper 29, a third piston stopper 30, and a fourth piston stopper 31 are provided. Furthermore, first rotating triangular teeth 53 are provided on the intermediate outer peripheral surface of the front end 26F and the rear end 26B so as to project rearward corresponding to the respective equally divided portions. Furthermore, the 2nd rotation triangular tooth 54 is provided in the 1st, 5th, 9th, 13th equally divided part in the outer periphery of the 1st rotation triangular tooth 53 toward the front-back direction, Parallel to the central axis 9, the halves are uniformly inclined. These triangular teeth are appropriately changed.

  In addition, the outer peripheral surface of the pressing ring 51 is formed in the same plane as the outer peripheral surface of the first rotating triangular tooth 53, and the pressing ring 51 is also divided into two parts that are equally divided into 16 around the central axis 9. Intermediate triangular teeth 55 that protrude rearward at equal intervals and can mesh with the first rotating triangular teeth 53 are provided. Further, an intermediate protrusion 56 is provided on the outer periphery of the pressing ring 51. Each of the intermediate protrusions 56 is provided in parallel to the central axis 9 from the position slightly retracted from the top of the intermediate triangular tooth 55 to the rear end.

  The rotary drive ring 52 is provided with a drive-side triangular tooth 57 with a sharp front at one, two, one, three, four, five, six, etc. At the same time, the back side of the top of the drive side triangular tooth 57 is formed with a halved side parallel to the central axis 9, and the intermediate projection 56 is slidable on the inner circumferential surface of the second halved portion. A driving-side groove 58 is formed in parallel with the central axis 9. The rear end 52B of the rotation drive ring 52 and the front part of the operating body 32, specifically, the front part of the sliding member 34 are connected by a rod-like connecting member 59.

  Accordingly, in the longitudinal motion-rotation motion converting means 33, in the state shown in FIG. 26, the first piston stopper 28 faces the front left and right window holes 11, and the piston 14 is provided on the first piston stopper 28. When the piston protrusion 10 is locked, the piston 14 is stopped. In this state, the first rotating triangular tooth 53 and the intermediate triangular tooth 55 of the piston stopper ring 26 and the pressing ring 51 are engaged with each other. When the operating body 32 moves forward for the medication operation, the rotational drive ring 52 also moves forward in conjunction therewith.

  Thereafter, as shown in FIG. 27, the second rotating triangular tooth 54 of the piston stopper ring 26 and the driving triangular tooth 57 of the rotation driving ring 52 come into contact with each other. And, as shown in FIG. 28, since the rotary drive ring 52 moves further forward, the linear motion is converted into rotational motion by the inclination of the second rotary triangular tooth 54 and the drive side triangular tooth 57, It is transmitted to the piston stopper ring 26. The rotational motion transmitted to the piston stopper ring 26 also acts on the first rotating triangular tooth 53 and the intermediate triangular tooth 55. Then, when the piston stopper ring 26 rotates, the rotational motion is reconverted into a linear motion so that the pressing ring 51 moves backward. That is, the forward linear motion of the rotary drive ring 52 has the effect of rotating the piston stopper ring 26 and causing the pressing ring 51 to linearly move backward.

  As shown in FIG. 29, the retaining ring 51 moves rearward until the intermediate triangular tooth 55 exceeds the top of the first rotating triangular tooth 53 of the piston stopper ring 26. As the piston stopper ring 26 rotates as shown in FIG. 30, the first rotating triangular tooth 53 exceeds the top of the intermediate triangular tooth 55 during the operation. At this time, the rotational drive ring 52 is pushed back by the elastic force of the coil spring 15. At this time, since the force acts so that the first rotating triangular tooth 53 and the intermediate triangular tooth 55 mesh with each other, the piston stopper ring 26 further rotates due to its effectiveness. Here, the contact between the second rotating triangular tooth 54 and the driving triangular tooth 57 ends, and immediately after that, the portion parallel to the central axis 9 in the second rotating triangular tooth 54 and the central axial line 9 in the driving triangular tooth 57 are parallel. Touching parts. In such a state, the second piston stopper 29 faces the front left and right window holes 11.

  Next, as shown in FIG. 31, the rotational drive ring 52 continues to move forward until the first rotating triangular tooth 53 and the intermediate triangular tooth 55 are completely engaged. At this time, the operating body 32 is operated. Since the trigger 16 is activated by the forward movement operation, the administration of the drug solution is completed.

  After the administration is completed in this manner, the operating body 32 is returned to the initial position for the next injection. With this operation, the rotational drive ring 52 is also moved rearward. At this time, the part parallel to the central axis 9 in the second rotational triangular tooth 54 and the part 54A parallel to the central axis 9 in the driving triangular tooth 57 are also provided. 57A remains in contact. Then, as shown in FIG. 33, when the rotary drive ring 52 moves to a position where the contact of the pair of parts ends, the pressing ring 51 is pushed forward by the coil spring 15. At this time, the piston stopper ring 26 rotates so that the inclination of the first rotating triangular tooth 53 and the driving side triangular tooth 57 is completely engaged. With such an operation, the operation of one injection and the preliminary operation for the next injection are completed.

  Next, the configuration will be described.

  In the initial state shown in FIG. 1, the piston 14 is disposed on the front side as indicated by the alternate long and short dash line, and the spring is in the expanded state. The piston 14 is retracted as indicated by the solid line from this initial state, and the coil spring 15 Compress. In such a preparation process, the hook 42 provided in the case body 6 in advance is locked to the first hook locking receiving portion 44, and a push rod (not shown) is inserted into the mounting hole 7. Then, the piston 14 is retracted and the coil spring 15 is compressed almost as much as possible, and the piston protrusion 10 integrated with the piston 14 is retracted, so that the fourth trigger locking receiver 22 and the third trigger locking receiver The trigger 16 is locked to the first trigger lock receiving portion 19 beyond the portion 21 and the second trigger lock receiving portion 20. At this time, the gripping operation body 32 is disposed between the trigger 16 and the hook 42. Further, the claw piece 36 of the spring holding member retreat connection means 35 is located behind the first claw piece locking receiving portion 37. Further, a first piston stopper 28 appears in the front left and right window holes 11.

  Next, the syringe 3 is attached to the case body 6 after the preparation process of FIG. 1 is completed as in the first process shown in FIG. The syringe 3 is attached in such a manner that the plunger 4 projecting rearward from the rear end 3B of the syringe 3 is inserted into the case body 6, and in the embodiment, between the piston 14 and the plunger 4. Is formed with a first gap I.

  Then, when the operating body 32 is slid forward and moved as in the second stroke shown in FIG. 3, the small protrusion 32A presses the front portion 16F of the trigger 16 inward, so that the rear portion 16B is lifted. The engagement with the first piston stopper 28 is released. Along with this release, the coil spring 15 extends a little and the piston 14 advances the first gap I and collides with the plunger 4 and then pushes the plunger 4 forward. When the piston 14 moves forward, a first piston stopper 28 appears in the front left and right window holes 11, and the piston protrusion 10 is locked to the first piston stopper 28 when the piston 14 moves forward. The piston 14 itself pressing the plunger 4 also stops corresponding to the position of the first piston stopper 28. In addition, the trigger 16 released from the small protrusion 32A is locked to the second trigger lock receiving portion 20. Then, when the piston 14 presses the plunger 4 from when the piston 14 comes into contact with the plunger 4 until the piston 14 stops by the first piston stopper 28, the first chemical solution can be ejected from the nozzle 5. it can.

  Next, as a preparation for performing the second injection as shown in the third step shown in FIG. When the guide pin 48 is pushed up, the hook 42 is detached from the first hook locking receiving portion 44. Further, by retracting the operating body 32, the claw piece 36 is engaged with the first claw piece latching receiving portion 37 and the spring case 8 is retracted together with the piston 14 as the operating body 32 is retracted. While the spring case 8 is moving backward, the tip of the hook 42 is engaged with the second hook engagement receiving portion 45 after the tip of the hook 42 has slid on the outer periphery of the spring case 8. As a result, the piston 14 integrated with the spring case 8 via the trigger 16 and the second trigger locking receiving portion 20 forms a second gap J for impact from the rear end 4B of the plunger 4. In this state, the coil spring 15 is in a compressed state and has a sufficient compressive force.

  Further, when the operating body is moved backward with respect to the case body 6, the hook guiding claw piece 49 gets over the guide pin 48 of the hook 42, and the claw piece 36 once passes through the first claw piece locking receiving portion 37. . The forward operation of the operating body 32 is performed by rotating the piston stopper ring 26 by ８ through the rod-like connecting member 59 and the forward motion / rotational motion conversion means 33, so that the second left and right window holes 11 have a second piston stopper. 29 appears.

  Next, as shown in FIG. 5, in the state where the nozzle 5 of the syringe 3 is pressed against the skin 60, when the operating body 32 is advanced, the small protrusion 32A presses the front end of the trigger 16 inward. FIG. 4 shows the piston 14 moving forward in the second gap J in an instant when the coil 16 is extended by releasing the lock between the trigger 16 and the second trigger 16 locking portion. By impinging on the rear end of the plunger 4 at the position and moving the plunger 4 forward, the chemical solution is ejected from the nozzle 5 to diffuse the chemical solution to the skin 60 side.

  The piston 14 that has advanced the plunger 4 in this manner is stopped when the piston projection 10 is locked to the second piston stopper 29, and the trigger 16 is moved to the third trigger lock receiving portion 21. Locked.

  Thereafter, similarly to the fifth to eighth strokes shown in FIGS. 6 to 9, the second to fourth ejection of the chemical liquid is performed with the third gap K and the fourth gap L for impact.

  That is, in the fifth stroke of FIG. 6, the operating body 32 is moved backward to release the hook 42 from the second hook locking receiving portion 45 and then locked to the third hook locking receiving portion 46. To do. During this time, the claw piece 36 that has detached the second claw piece locking receiving portion 38 is locked to the third claw piece locking receiving portion 39 and the spring case 8 is moved together with the piston 14 as the operating body 32 moves backward. By retreating, a third gap K for impact is formed. Further, by retracting the operating body 32, the third piston stopper 30 appears in the front left and right window holes 11. The trigger 16 is locked to the third trigger lock receiving portion 21, and the coil spring 15 is in a compressed state and has a compressive force.

  In the sixth stroke of FIG. 7, by moving the operating body 32 forward, the small protrusion 32A presses the front end of the trigger 16, and the locking state between the trigger 16 and the third trigger 16 locking portion is released, As the coil spring 15 expands, the piston 14 advances in the third gap K instantly and collides with the rear end of the plunger 4 at the position shown in FIG. The chemical solution is ejected and diffused to the skin 60 side.

  The piston 14 having advanced the plunger 4 in this manner is stopped when the piston projection 10 is locked to the third piston stopper 30, and the trigger 16 is moved to the third trigger lock receiving portion 21. Locked.

  In the seventh step of FIG. 8, the operating body 32 is retracted, so that the hook 42 is unlocked from the third hook locking receiving portion 46 and then locked to the fourth hook locking receiving portion 47. During this time, the claw piece 36 that has removed the third claw piece locking receiving portion 39 is locked to the fourth claw piece locking receiving portion 40 and the spring case 8 is moved together with the piston 14 as the operating body 32 moves backward. The fourth gap L for impact is formed by retreating. Further, by retracting the operating body 32, a fourth piston stopper 31 appears in the front left and right window holes 11. The trigger 16 is locked to the fourth trigger lock receiving portion 22. In this state, the coil spring 15 is in a compressed state and a compressive force remains.

  In the eighth stroke of FIG. 9, by moving the operating body 32 forward, the small protrusion 32A presses the front end of the trigger 16, and the locking state between the trigger 16 and the fourth trigger 16 locking portion is released. As the coil spring 15 expands, the piston 14 moves forward in the fourth gap L instantly and collides with the rear end of the plunger 4 at the position shown in FIG. 8 to advance the plunger 4 to the back side of the syringe 3. By doing so, the chemical solution is ejected from the nozzle 5 and diffused to the skin 60 side.

  The piston 14 having advanced the plunger 4 in this manner is stopped when the piston projection 10 is locked to the fourth piston stopper 31, and the rear end of the trigger 16 is in contact with the outer periphery of the spring case 8. ing.

  Thereafter, the emptied syringe 3 is removed from the mounting hole 7 of the case main body 6, and a new syringe 3 is mounted in the mounting hole 7 again as shown in FIGS.

  As described above, in the embodiment, the coil spring 15 is provided in the spring case 8, the spring holding member / piston connection means 24 is interposed between the spring case 8 and the piston 14, and the spring case 8 is When the plunger 4 is pressed after the coil spring 15 is compressed once by being provided slidably with respect to the case body 6 and provided with the machine frame body / spring holding member connecting means 41, the piston is previously provided. Since the first gap I, the second gap J, and the third gap K for impact can be formed between the plunger 14 and the plunger 4 each time, the drug solution can be dispersed and administered. . Therefore, it is not necessary to compress the spring for each medication, and by carrying the needleless syringe 1 set in the drive device 2, for example, a drug solution can be administered immediately at mealtime.

  The case body 6 is provided with piston stoppers 28, 29, 30, and 31 for the piston 14. The piston stoppers 28, 29, 30, and 31 are provided corresponding to the forward direction of the piston 14, and the piston 14 is a piston stopper. By selectively responding to 28, 29, 30, and 31, the medical solution can be administered by intermittently advancing the piston 14 after compressing the spring once.

  Further, the operating body 32 is provided on the case body 6, and the spring holding member retracting connection means 35 that can be attached to and detached from the spring case 8 is provided on the operating body 32. The second gap J, the third gap K, and the fourth gap L can be formed by retreating.

  Further, in the spring holding member / piston connecting means 24, the trigger 16 is selectively applied to the second trigger locking receiving portion 20, the third trigger locking receiving portion 21, and the fourth trigger locking receiving portion 22. By locking, it can be reliably administered.

  Further, in the machine frame main body / spring holding member connecting means 41, the case main body 6 is provided with a hook 42, and a plurality of first hook locking receiving portions 44, which are capable of locking the hook 42 to the spring case 8, a second one. A hook locking receiving portion 45, a third hook locking receiving portion 46, and a fourth hook locking receiving portion 47 are provided, and the hook 42 is selectively used as a plurality of hook locking receiving portions 44, 45, 46, 47. By locking, the second gap J, the third gap K, and the fourth gap L can be reliably ensured.

  The piston stoppers 28, 29, 30, 31 are disposed in the front left and right window holes 11 which are moving paths of the piston protrusions 10 provided on the piston 14, and the piston stoppers 28, which are selectively locked by the piston protrusions 10, By being 29, 30, 31 it is possible to stop the piston 14 directly so that no malfunction occurs.

  Further, the operating body 32 is provided with a small protrusion 32A as an activation part of the spring holding member / piston connecting means 25 and a hook guide claw piece 49 which is a driving part of the machine frame main body / spring holding member connecting means 41. Thus, the operating body 32 can operate the spring holding member / piston connecting means 25 and the machine frame main body / spring holding member connecting means 41.

  Further, since the operating body 32 includes the grip portion 32B and the case body 6 is slidably provided, the operation body 32 can be easily operated by moving the operating body 32 back and forth.

  In addition, after the coil spring 15 is partially extended by a part of the elasticity of the compressed coil spring 15 to advance the piston 14 and collide with the plunger 4, the coil spring 15 is retracted together with the piston 14 to move the plunger 4. After the second gap J for impact is formed between the piston 14 and the piston 14, the coil spring 15 is extended again by the elasticity of the remaining coil spring 15 to advance the piston 14 and collide with the plunger 4. Thus, it is not necessary to compress the spring for each dose, and divided doses are possible.

  Further, by repeatedly retreating the coil spring 15 together with the piston 14 and causing the piston 14 to collide with the plunger 4 a plurality of times, a plurality of divided doses can be performed.

  FIG. 43 shows the second embodiment, and the same parts as those of the first embodiment are denoted by the same reference numerals, and detailed description thereof is omitted. In the second embodiment, grooves 70 are provided on the front left and right sides of the case body 6 at a plurality of intervals along the central axis 9, and piston stopper pins 72 provided on the left and right sides of the stopper body 71 at appropriate positions of the grooves 70. The piston stopper pin 72 is protruded from the inside of the case body 6 so that the piston 14 can be advanced, and the plunger 4 can be pushed out to a predetermined length.

  Such a stopper main body 71 can be replaced with a predetermined groove 70 to manually provide a piston stopper.

  As described above, the needleless syringe driving apparatus according to the present invention can be applied to various applications. Further, the number of times the plunger is pressed is not limited to four, and various modifications such as a plurality of times are possible. Furthermore, the spring is not limited to a coil spring but may be an air spring or the like.

DESCRIPTION OF SYMBOLS 1 Needleless syringe 2 Drive device 3 Syringe 3B Rear end 4 Plunger 4B Rear end 6 Case main body (machine frame main body)
8F front end
11 Front left and right window holes (travel path)
15 Coil spring (spring)
16 trigger
20, 21, 22 Trigger lock receiving part
24 Spring holding member / piston connection means
25 Spring holding member / piston connection means
28, 29, 30, 31 Piston stopper
32 Control body
32A small protrusion (starting part)
32B Grip part
35 Spring holding member retreat connection means
42 hook
44, 45, 46, 47 Hook latch receiving part
41 Machine body / spring holding member connection means
49 Hook guide claw piece (drive unit)
I, J, K gap

Claims (10)

A machine frame body to which a syringe of a needleless syringe provided with a nozzle at the front end and a plunger slidably mounted is attached to the front part, and provided in this machine frame body so as to be movable forward facing the plunger. A piston that can press the plunger, and a spring that is provided on the main body of the machine body and presses the piston forward. The compressed spring is extended to advance the piston and press the plunger. In the drive device of the needleless syringe that
The spring is provided on a spring holding member, and a detachable spring holding member / piston connecting means is interposed between the spring holding member and the piston, and the spring holding member is attached to the machine frame main body. A drive unit for a needleless syringe, characterized in that a machine frame main body / spring holding member connecting means is provided slidably rearward and removable between the machine frame main body and the spring holding member.   A plurality of piston stoppers of the piston are provided in the machine frame body, the piston stoppers are provided corresponding to the forward direction of the piston, and the piston selectively stops corresponding to the plurality of piston stoppers. The needleless syringe drive device according to claim 1.   The needleless syringe drive device according to claim 1 or 2, wherein an operating body is provided in the machine body, and a spring holding member retracting connection means detachable from the spring holding member is provided on the operating body.   The spring holding member / piston connecting means is provided with a trigger for a medication operation in the machine frame main body, and provided with a plurality of trigger locking receiving portions capable of locking the trigger on a piston extension member integrated with the piston. 4. The needleless syringe driving device according to claim 3, wherein the plurality of trigger locking receiving portions are selectively locked.   The machine frame main body / spring holding member connecting means is provided with a hook on the machine frame main body, and the spring holding member is provided with a plurality of hook locking receiving portions capable of locking the hook, and the hook is the plurality of hooks. The needleless syringe drive device according to claim 4, wherein the needleless syringe drive device is selectively locked to the locking receiving portion.   The drive device for a needleless syringe according to claim 2, wherein the plurality of piston stoppers are disposed in a movement path of a piston protrusion provided on the piston, and the piston protrusion is selectively locked.   4. The needleless syringe according to claim 3, wherein the operating body is provided with a starting portion for the spring holding member / piston connecting means and a driving portion for the machine frame main body / spring holding member connecting means. Drive device.   8. The needleless syringe driving apparatus according to claim 7, wherein the operating body includes a grip portion and is slidably provided on the machine body.   A machine frame body to which a syringe of a needleless syringe provided with a nozzle at the front end and a plunger slidably mounted is attached to the front part, and provided in this machine frame body so as to be movable forward facing the plunger. A piston that can press the plunger, and a spring that is provided on the main body of the machine body and presses the piston forward. The compressed spring is extended to advance the piston and press the plunger. In the driving method of the needleless syringe driving device, the spring is partially extended by a part of the elastic force of the compressed spring, the piston is advanced to collide with the plunger, and then the spring is moved to the piston. And the impact gap is formed between the plunger and the piston. The driving method of the needle-free syringe driving apparatus characterized by by stretching the roots by advancing the piston to collide with the plunger.   The driving method of the drive device for the needleless syringe according to claim 9, wherein the spring is repeatedly retracted together with the piston to cause the piston to collide with the plunger a plurality of times.

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