JP5574844B2 - Syringe container - Google Patents

Description

  The present invention relates to a syringe container for cooling and storing liquid agents such as drugs and adhesives.

  As a syringe container for storing a liquid agent such as a drug or an adhesive, for example, in Patent Document 1, an injection needle connecting portion is formed at the tip, and the drug is placed in a cylinder loaded with a slide plug inside the rear end opening. In the prefilled syringe with a cap on the injection needle connecting portion, the outer peripheral surface of the cylinder is covered with a shrink film, and the shrink film removes the cap from the injection needle connecting portion. There is disclosed a prefilled syringe characterized in that the coated shrink film is cut off at the end of a cylinder.

  Moreover, as a mechanism for adjusting the pressure in the container, for example, Patent Document 2 discloses a metal or hard resin cap fitted with a screw to a hard resin packaging container mouth / neck portion to which a screw is attached, a packaging container, A container dent-preventing cap is disclosed in which an inner lid made of a predetermined elastic material is mounted between the two. The inner lid is a check valve inner lid.

JP 2005-312932 A Japanese Utility Model Publication No. 48-24845

  In FIG. 3, the schematic diagram of the conventional syringe container 10 is shown. The syringe container 10 illustrated in FIG. 3 includes a barrel 20, a plunger 30, and a barrel cap 40. A liquid agent 70 such as a medicine or an adhesive is filled in the liquid agent filling portion 27 of the cylindrical space 26 inside the barrel 20. The liquid agent 70 in the cylindrical space 26 is filled so as to be covered with the plunger 30. Therefore, the plunger 30 is positioned at the boundary between the liquid agent filling portion 27 in the cylindrical space 26 inside the barrel 20 and a space where the liquid agent 70 does not exist (referred to as “non-filling space 28” in this specification). . When taking out the liquid agent 70 from the liquid agent filling unit 27, the barrel cap 40 and the liquid agent outlet hole lid 60 are removed, and a plunger rod (not shown) is pressed against the plunger 30 or pressed by applying a gas pressure or the like. Thus, the liquid agent 70 can be extracted from the liquid agent extraction hole 22.

  The liquid agent 70 such as a medicine filled in the syringe container 10 may be required to be stored at a low temperature, for example, below freezing point, in order to prevent quality deterioration. Although the storage temperature differs depending on the type of the liquid agent 70, for example, the storage temperature may be −20 to −40 ° C. Moreover, when storing for a long time for a long distance transfer, storage temperature may be set to -60 degrees C or less.

  When returning the liquid agent 70 to room temperature after low temperature storage, the inventors of the present application pass through the gap between the plunger 30 and the inner wall of the barrel 20 and the liquid agent 70 filled in the syringe container 10 enters the non-filling space 28. We found that the problem of getting in could occur. FIG. 7 shows a photograph of the syringe container 10 in a state where the liquid agent 70 does not exist in the non-filling space 28. 8 and 9 show examples of photographs of the syringe container 10 that has been stored at a low temperature and then returned to room temperature. As shown in FIGS. 8 and 9, in the syringe container 10 after low-temperature storage, the liquid agent 70 may enter the non-filling space 28 through the gap between the plunger 30 and the inner wall of the barrel 20. is there. The inventors of the present application have also found that the above problem that the liquid agent 70 enters the non-filling space 28 is frequently generated when the viscosity of the liquid agent 70 is in the range of 100 mPa · s to 5000 mPa · s. It was.

  Furthermore, although the frequency is not high, when the liquid 70 filled in the syringe container 10 is cooled from room temperature to a low temperature for low-temperature storage, the liquid 70 is not filled as in the case of returning the liquid 70 to room temperature. A problem of entering the space 28 may occur.

  As shown in FIGS. 8 and 9, the liquid 70 that has entered the non-filling space 28 cannot be taken out from the barrel 20 and cannot be used. In general, since the liquid agent 70 is expensive, the occurrence of unused parts causes a problem of increased cost. Further, the liquid amount sensor using the optical sensor may malfunction due to the liquid agent 70 entering into an unexpected place such as a gap between the plunger 30 and the inner wall of the barrel 20 or the non-filling space 28. In addition, when the liquid agent 70 is used, a syringe adapter is attached to the barrel cap 40 in order to supply gas pressure to the non-filling space 28. When the liquid agent 70 enters the non-filling space 28 or the like, the liquid agent 70 splatters and adheres to the syringe adapter when the gas pressure is supplied from the syringe adapter. May be required.

  When returning the liquid agent 70 to room temperature after low temperature storage, the inventors of the present application pass through the gap between the plunger 30 and the inner wall of the barrel 20 and the liquid agent 70 filled in the syringe container 10 enters the non-filling space 28. It was inferred that the problem of entering was caused by a temperature change inside the syringe container 10 due to low temperature storage or thawing after storage. That is, for example, if the plunger 30 is difficult to move when the temperature of the liquid agent 70 rises, the liquid agent 70 that expands due to the temperature rise passes through the gap between the plunger 30 and the inner wall of the barrel 20 and is not filled. 28 can be considered. In addition, the gas pressure in the non-filling space 28 changes greatly during low-temperature storage or thawing after storage. Therefore, when the syringe container 10 is taken out from the low-temperature storage, the inside of the closed non-filling space 28 is removed. It is conceivable that the pressure of the gas increases and the plunger 30 is pressed. For this reason, the plunger 30 becomes difficult to move, and the expanding liquid agent 70 may enter the gap between the plunger 30 and the inner wall of the barrel 20. Furthermore, it is also conceivable that the plunger 30 moves slightly toward the liquid agent filling portion 27 to apply pressure to the liquid agent 70. As described above, various factors are combined when the temperature of the syringe container 10 changes, and it is inferred that the liquid agent 70 passes through the gap between the cylindrical space 26 and the plunger 30 and enters the non-filling space 28. did. In addition, when the liquid agent 70 filled in the syringe container 10 is cooled from room temperature to a low temperature, the problem that the liquid agent 70 enters the non-filling space 28 can also be inferred to be due to the pressure change of the gas in the non-filling space 28. .

  Note that the problem that the liquid agent 70 enters the non-filling space 28 does not always occur, and occurs at a certain frequency. Therefore, in addition to the change in the pressure of the gas in the non-filling space 28, It can be inferred that various factors such as a dimensional error between the inner diameter of the cylindrical space 26 and the maximum outer diameter of the plunger 30 and a slight gap between the barrel cap 40 and the barrel 20 are combined.

  In order to solve the problem that the liquid agent 70 enters the non-filling space 28, the dimensional error between the inner diameter of the cylindrical space 26 of the barrel 20 and the maximum outer diameter of the plunger 30 is reduced, and the dimensional accuracy is increased. It is conceivable to eliminate the gap between the space 26 and the plunger 30. However, increasing the dimensional accuracy of the disposable syringe container 10 is not realistic because it leads to an increase in cost. Further, if the dimensional error between the inner diameter of the cylindrical space 26 of the barrel 20 and the maximum outer diameter of the plunger 30 is too small, the plunger 30 becomes difficult to move, so the discharge controllability when discharging the liquid agent 70 is deteriorated. Problems such as variations in the discharge amount occur.

  Therefore, the present invention is a low-cost syringe container 10 that does not cause a problem that the liquid agent 70 enters the non-filling space 28 when the liquid agent 70 filled in the syringe container 10 is stored at a low temperature. It aims at obtaining the syringe container 10 for supplying the liquid agent 70 by this.

  In particular, when the viscosity of the liquid filled in the syringe container is in the range of 100 mPa · s to 5000 mPa · s, the frequency of occurrence of the above problems is high, and the liquid enters the unfilled space during low-temperature storage. An object of the present invention is to obtain a syringe container for supplying a liquid agent at a low cost.

  As a result of diligent efforts, the inventors of the present application have inferred that the cause of the above problem is due to the temperature change inside the syringe container 10 as described above. Furthermore, the inventors of the present application have inferred that the occurrence of the above problem can be reduced if the pressure change of the gas in the unfilled space 28 due to the temperature change can be prevented. Therefore, the inventors of the present invention, based on the above inference, add a mechanism for adjusting the pressure in the unfilled space of the barrel in the syringe container, so that the liquid medicine such as the medicine and adhesive filled in the syringe container can be stored at low temperature. In this case, the present inventors have found that the problem that the liquid agent does not enter the non-filling space does not occur, and have reached the present invention.

  That is, the present invention has a cylindrical space, one end of the cylindrical space is a liquid agent extraction hole, the other end of the cylindrical space is an opening, and the cylindrical space is filled with a liquid agent on the liquid agent extraction hole side. And a plunger having a maximum outer diameter substantially the same as the inner diameter of the cylindrical space, and a barrel opening so as to be divided in two into a non-filling space on the opening side and a pressure, It is a syringe container containing the barrel cap which has an adjustment mechanism. When the barrel cap has a pressure adjusting mechanism, the liquid agent can be prevented from entering the non-filling space when the liquid agent filled in the syringe container is stored at a low temperature.

The preferable aspect of the syringe container of this invention is shown below. In the present invention, these embodiments can be appropriately combined.
(1) The pressure adjustment mechanism is at least one selected from the group consisting of a through hole, a seal, a check valve, and a diaphragm. By adopting one selected from these pressure adjustment mechanisms, it is possible to prevent the entry of impurities from the outside at a low cost, and a more reliable pressure adjustment mechanism can be added to the barrel cap.
(2) The above-mentioned syringe container is a container for storing the liquid agent at a low temperature. The syringe container of the present invention can be suitably used for storing liquid agents such as drugs and adhesives at a low temperature.

  According to the present invention, when a liquid medicine filled in a syringe container is stored at a low temperature, it is a low-cost syringe container that does not cause a problem that the liquid medicine enters an unfilled space, and for supplying the liquid medicine at a low cost. A syringe container can be obtained.

  In particular, when the viscosity of the liquid agent filled in the syringe container is in the range of 100 mPa · s to 5000 mPa · s, the low cost does not cause a problem that the liquid agent enters the non-filling space during low-temperature storage. A syringe container for supplying a liquid agent at low cost can be obtained.

It is a cross-sectional schematic diagram which shows an example of the syringe container of this invention. It is a cross-sectional schematic diagram which shows an example of the barrel of a syringe container. It is a cross-sectional schematic diagram which shows the conventional syringe container. It is a cross-sectional schematic diagram which shows an example of the barrel cap which has a pressure adjustment mechanism by a seal | sticker. It is a cross-sectional schematic diagram which shows an example of the barrel cap which has a pressure adjustment mechanism by a non-return valve. It is a cross-sectional schematic diagram which shows an example of the barrel cap which has a pressure adjustment mechanism by a diaphragm. It is a photograph which shows the syringe container in the state in which the liquid agent does not exist in the non-filling space. It is a photograph of an example of the syringe container in a state where the liquid agent enters the non-filling space through the gap between the plunger and the inner wall of the barrel. It is a photograph of another example of the syringe container in a state where the liquid agent enters the non-filling space through the gap between the plunger and the inner wall of the barrel. It is a schematic diagram which shows a mode that the liquid agent penetrate | invaded between the syringe inner wall and the plunger, Comprising: It is a figure which shows the length X of the part which the plunger contacts the length X of a liquid agent penetration | invasion part, and a syringe inner wall.

  In FIG. 1, the cross-sectional schematic diagram of an example of the syringe container 10 of this invention is shown. The present invention is a syringe container 10 including a barrel 20, a plunger 30, and a barrel cap 40, wherein the barrel cap 40 has a pressure adjustment mechanism 50. The pressure in the unfilled space 28 of the barrel 20 of the syringe container 10 can be adjusted by the pressure adjusting mechanism 50 of the barrel cap 40. Therefore, even if the temperature of the syringe container 10 changes, the pressure change of the gas in the non-filling space 28 can be alleviated, so that the plunger 30 can be prevented from applying pressure to the liquid agent 70, It is possible to prevent the liquid agent 70 from entering the non-filling space 28 through the gap therebetween. The present invention will be described in detail below.

  The syringe container 10 of the present invention has a barrel 20. FIG. 2 shows a schematic diagram of an example of the barrel 20. The barrel 20 has a cylindrical shape having a cylindrical space 26 therein. The liquid agent extraction hole 22 is disposed at one end of the cylindrical space 26. The liquid agent extraction hole 22 has a thin tubular projection shape so that an injection needle or the like can be connected. An opening 24 is disposed at one end (the other end) of the cylindrical space 26 on the opposite side to the liquid agent extraction hole 22. In order to insert the plunger 30 having the maximum outer diameter substantially the same as the inner diameter of the cylindrical space 26, the diameter of the opening 24 is the same as the diameter of the cylindrical space 26. The material of the syringe container 10 can be appropriately selected from resin materials, particularly transparent or translucent resin materials. Specifically, polypropylene can be used as the material of the syringe container 10.

The syringe container 10 has various sizes depending on the volume in which the liquid agent 70 is filled, and generally has a volume of about 1 to 100 cm ² . The inner diameter of the cylindrical space 26 of the barrel 20 is generally about 3 to 30 mm corresponding to the volume filled with the liquid agent 70. The syringe container 10 of the present invention can be applied to the syringe container 10 of any size generally used by appropriately selecting the dimensions of the barrel 20 and the plunger 30 and the like.

  The syringe container 10 of the present invention has a plunger 30. The plunger 30 is inserted from the opening 24 and is disposed in the cylindrical space 26 so as to bisect the cylindrical space 26 of the barrel 20. The portion of the cylindrical space 26 that is divided into two parts by the plunger 30 is the liquid agent filling portion 27 for filling the liquid agent 70. Further, the portion on the opening 24 side of the cylindrical space 26 divided by the plunger 30 is a space where the liquid agent 70 does not exist (non-filling space 28). The liquid agent 70 in the cylindrical space 26 is filled so as to be covered by the plunger 30. Therefore, the plunger 30 is positioned at the boundary between the liquid agent filling portion 27 of the cylindrical space 26 inside the barrel 20 and the non-filling space 28.

  The plunger 30 may have a disk shape, but is not limited thereto, and is airtight when positioned at the boundary between the liquid agent filling portion 27 of the cylindrical space 26 inside the barrel 20 and the non-filling space 28. Any shape can be used as long as it is slidable. The maximum outer diameter of the plunger 30 is substantially the same as the inner diameter of the cylindrical space 26. Therefore, ideally, the material is hermetically sealed so that the movement of the substance between the liquid filling portion 27 and the non-filling space 28 does not basically occur. Since the plunger 30 is basically slidable, the barrel cap 40 and the liquid agent outlet hole lid 60 are removed when the liquid agent 70 of the liquid agent filling portion 27 is taken out, and a plunger rod (not shown) is attached to the plunger 30. The liquid agent 70 can be taken out from the liquid agent take-out hole 22 by being pressed or pressed by application of gas pressure or the like. In addition, as a material of the plunger 30, a hard material, a resin material, and a material (for example, elastic body etc.) which has a softness | flexibility can be selected suitably, and can be used. Specifically, the material of the plunger 30 can be polyethylene.

  The syringe container 10 of the present invention has a barrel cap 40. The schematic diagram of an example of the syringe container 10 of this invention which has the barrel cap 40 in FIG. 1 is shown. The barrel cap 40 is attached to the opening 24 of the barrel 20 in order to seal the cylindrical space 26 containing the liquid agent 70.

  The barrel cap 40 of the syringe container 10 of the present invention is characterized by having a pressure adjusting mechanism 50 for adjusting the pressure in the non-filling space 28. Since the barrel cap 40 has the pressure adjustment mechanism 50, after the syringe container 10 filled with the liquid agent 70 is stored at a low temperature, it is stored at, for example, -20 to -40 ° C, further -60 ° C or less, and then to the room temperature. When the temperature is raised, it is possible to prevent the gas pressure in the sealed unfilled space 28 from increasing. Therefore, the gas in the non-filling space 28 can be prevented from pressing the plunger 30, and the liquid agent 70 can pass through the gap between the cylindrical space 26 and the plunger 30 and enter the non-filling space 28. Can be prevented.

  As the pressure adjusting mechanism 50 of the barrel cap 40 of the syringe container 10 of the present invention, one or more selected from the group consisting of the through hole 42, the seal 51, the check valve 52, and the diaphragm 56 can be used. For example, the seal 51 and the check valve 52 are provided in the barrel cap 40 and can be used together with a through hole 42 that forms a gas flow path between the non-filling space 28 and the outside of the syringe container 10. Further, only the through hole 42 can be used as the pressure adjusting mechanism 50 of the barrel cap 40. Further, the barrel cap 40 may have a plurality of pressure adjustment mechanisms 50 selected from the seal 51, the check valve 52, the diaphragm 56, and the like. More specifically, only the through hole 42, the combination of the through hole 4 and the seal 51 or the check valve 52, and the pressure adjusting mechanism 50 selected from the diaphragm 56 can be used.

  FIG. 4 shows a schematic cross-sectional view of an example of the barrel cap 40 having the pressure adjusting mechanism 50 by the seal 51. The pressure adjustment mechanism 50 using the seal 51 has a structure in which a small-diameter through hole 42 is provided in the barrel cap 40 and the seal 51 is attached to the outside of the through hole 42 with an adhesive or the like. When the pressure of the gas in the non-filling space 28 is increased by the pressure adjusting mechanism 50 by the seal 51, a passage through which air can pass through a part of the part bonded with an adhesive or the like is formed. A part of the gas in the filling space 28 can escape to the outside, and an increase in pressure in the non-filling space 28 can be prevented. Further, when the gas in the non-filling space 28 is depressurized, it is sealed by the seal 51, so that the inflow of outside air into the syringe container 10 can be prevented. Therefore, it is possible to prevent deterioration due to contact of the liquid agent 70 with the outside air during low-temperature storage or the like.

  FIG. 5 shows a schematic cross-sectional view of an example of the barrel cap 40 having the pressure adjustment mechanism 50 by the check valve 52. The pressure adjusting mechanism 50 using the check valve 52 has a structure in which a small diameter through hole 42 is provided in the barrel cap 40 and the check valve 52 is disposed in the through hole 42. As the check valve 52, for example, a valve having a structure in which a lid-like part that is movably fixed by the movable fixing part 53 is disposed in the outer opening part of the small-diameter through hole 42 is used. it can. As shown by a dotted line in FIG. 5, when the check valve 52 includes a pressure adjustment mechanism 50 using the check valve 52 that can move with the movable fixed portion 53 as a fulcrum, the non-filling space 28 is placed outside the syringe container 10. Gas can pass only in the direction of. Therefore, when the pressure of the gas in the non-filling space 28 increases, part of the gas in the non-filling space 28 can be released to the outside, and an increase in the pressure in the non-filling space 28 can be prevented. it can. Further, when the gas in the non-filling space 28 is depressurized, the check valve 52 can prevent the outside air from flowing into the syringe container 10. Therefore, it is possible to prevent deterioration due to contact of the liquid agent 70 with the outside air during low-temperature storage or the like.

  Moreover, in the example shown in FIG. 4 or FIG. 5, the through hole 42 can be simply provided as the pressure adjusting mechanism 50 of the barrel cap 40. In this case, the seal 51 and the check valve 52 are not necessarily required. Since the through hole 42 allows gas to pass between the non-filling space 28 and the outside of the syringe container 10, it can serve as the pressure adjustment mechanism 50. However, in order to ensure that impurities are not mixed through the through holes 42 and liquid agent deterioration due to contact with the outside air is prevented, the pressure adjusting mechanism 50 is shown in FIG. 4 or FIG. 5 in addition to the through holes 42. It is preferable to use a seal 51 or a check valve 52 as shown.

  FIG. 6 shows a schematic cross-sectional view of an example of the barrel cap 40 having the pressure adjusting mechanism 50 by the diaphragm 56. The pressure adjusting mechanism 50 using the diaphragm 56 has a structure in which a through hole 42 is provided in a part or the whole of the barrel cap 40, and the diaphragm 56 is disposed in an outer opening portion of the through hole 42. When the pressure adjusting mechanism 50 by the diaphragm 56 is provided, the pressure increase or the pressure decrease of the gas in the non-filling space 28 is caused by the volume increase (diaphragm 56a in FIG. 6) or the volume decrease (diaphragm in FIG. 6) due to the deformation of the diaphragm 56. 56b). Therefore, a pressure change in the non-filling space 28 can be prevented. Further, since the outside of the syringe container 10 and the non-filling space 28 are sealed by the diaphragm 56, the outside air does not enter the syringe container 10. Therefore, it is possible to prevent deterioration due to contact of the liquid agent 70 with the outside air during low-temperature storage or the like.

  As a material constituting the diaphragm 56, a material having flexibility at a low storage temperature when storing the syringe container 10 of the present invention can be used. Specifically, various rubbers having a predetermined glass transition point can be used according to the low storage temperature when storing the syringe container 10 of the present invention. For example, when the storage temperature at a low temperature is −20 to −40 ° C., rubber having a glass transition point of −50 ° C. or lower can be used. Specifically, as a material having a glass transition point of −50 ° C. or less capable of constituting the diaphragm 56, nitrile rubber, silicone rubber, ethylene propylene rubber, natural rubber, styrene butadiene rubber, butyl rubber, butadiene rubber, and polysulfide rubber One or more types selected from can be used. When the storage temperature is −60 ° C. or lower, the material constituting the diaphragm 56 is nitrile rubber (Tg = −85 ° C.), silicone rubber (Tg = −125 to −112 ° C.), and butadiene rubber (Tg = −110). It is preferable to use one or more selected from -90 ° C.

  The syringe container 10 of the present invention can be suitably used as a container for storing a liquid agent 70 such as a medicine or an adhesive at a low temperature. Since the syringe container 10 of the present invention has the pressure adjustment mechanism 50 in the barrel cap 40, there is a case where some errors occur in dimensional accuracy such as the inner diameter of the cylindrical space 26 of the barrel 20 and the maximum outer diameter of the plunger 30. Even so, the liquid agent 70 can be prevented from passing through the gap between the cylindrical space 26 and the plunger 30. Therefore, when manufacturing the syringe container 10 of this invention, it is not necessary to raise a dimensional accuracy remarkably, and manufacturing cost can be reduced. Moreover, since it can prevent that the useless liquid agent 70 which enters into the non-filling space 28 is generated, the liquid agent 70 can be supplied at low cost.

  The frequency of occurrence of the problem that the liquid 70 enters the non-filling space 28 is particularly high when the viscosity of the liquid 70 is in the range of 100 mPa · s to 5000 mPa · s. If the syringe container 10 of the present invention is used, the occurrence frequency of the above problem can be greatly reduced even when the viscosity of the liquid agent 70 is in the range of 100 mPa · s to 5000 mPa · s.

A 30 cc syringe (inner diameter: 23 mm, inner length: 110 mm) is filled with 20 g of NAMICS COF underfill agent (specific gravity 1.1 g / cm ³ , viscosity 500 mPa · s at 25 ° C.) as a liquid epoxy resin composition. The plunger was inserted. Next, as a pressure adjusting mechanism, a barrel cap provided with a through-hole having a diameter of 5 mm was attached to the opening of the syringe container to obtain an example (experiment numbers A1 to A10). Moreover, what attached the barrel cap which does not provide the through-hole to the opening part of the syringe container was used as a comparative example (experiment number B1-B10). The dimensions of the syringe containers and barrel caps used in the examples and comparative examples were all the same except for the presence or absence of through holes. Next, 10 of each of Examples and Comparative Examples were frozen in a freezer at -40 ° C for 24 hours, and then allowed to thaw at room temperature (25 ° C).

  After thawing the containers of Examples and Comparative Examples, the length of the liquid agent intrusion portion was measured. Here, the “length of the liquid agent intrusion portion” is the length of the portion where the plunger contacts the inner wall of the syringe and the liquid agent enters between the syringe inner wall and the plunger, and the liquid agent enters from the liquid agent filling portion. This is the distance to the tip of the part. Specifically, the length X shown in FIG. 10 is referred to as “the length of the liquid agent intrusion portion”. In addition, the “liquid agent intrusion ratio” is obtained by dividing “the length of the liquid agent intrusion portion” (length X shown in FIG. 10) by the length of the portion where the plunger contacts the inner wall of the syringe (length D shown in FIG. 10). Ratio (X / D). The plunger used in the examples and comparative examples was adapted for a 30 cc syringe (with an inner diameter of 23 mm) and had a length D = 10 mm.

  Table 1 shows values of the liquid agent intrusion ratio (X / D) obtained from the measurement results of the length X of the liquid agent intrusion portion in the examples and comparative examples. As is clear from Table 1, the number of changes (C-A) in the liquid agent entry ratio (X / D) comparing before (A) and after thawing (C) is increased by 10% or more. In the examples of the invention (experiment numbers A1 to A10), the number was 0 out of 10. On the other hand, in the comparative examples (experiment numbers B1 to B10), the change (C / A) in the liquid agent entry ratio (X / D) comparing before (A) and after thawing (C) increased by 10% or more. There were 6 out of 10. In addition, all changes (C-A) in the liquid agent entry ratios (X / D) of the experiment numbers A1 to A10 which are examples of the present invention are the changes (CA) of the experiment numbers B1 to B10 which are comparative examples. It was smaller. In addition, when comparing before freezing (A) and after freezing (B), the change (BA) of the liquid agent entry ratio (X / D) is compared in the example of the embodiment of the present invention. It was generally smaller than the example. From the above, it can be said that if the syringe container of the present invention is used, the occurrence frequency of the problem that the liquid agent enters the non-filling space can be greatly reduced.

  In this example, a barrel cap having a through hole was used as the pressure adjusting mechanism. Even when the pressure adjustment mechanism is a seal, a check valve, a diaphragm, or the like, the pressure of the syringe container can be adjusted, so that the liquid agent enters the non-filling space as in the case of the through hole. It is presumed that the occurrence frequency can be greatly reduced.

DESCRIPTION OF SYMBOLS 10 Syringe container 20 Barrel 22 Liquid agent extraction hole 24 Opening part 26 Cylindrical space 27 Liquid agent filling part 28 Non-filling space 30 Plunger 40 Barrel cap 42 Through hole 50 Pressure adjustment mechanism 51 Seal 52 Check valve 53 Movable fixed part 56 Diaphragm 56a Diaphragm (When pressure rises in unfilled space)
56b Diaphragm (at the time of pressure drop in non-filling space)
60 Liquid agent outlet hole cover 70 Liquid agent

Claims (3)

A syringe container for storing a liquid at a low temperature,
A barrel having a cylindrical space, one end of the cylindrical space is a liquid agent outlet hole, and the other end of the cylindrical space is an opening;
The cylindrical space is arranged in the cylindrical space so as to bisect the liquid agent filling portion on the liquid agent outlet hole side and the non-filling space on the opening side, and the maximum outer diameter is substantially the same as the inner diameter of the cylindrical space . A polyethylene plunger;
A syringe container including a barrel cap attached to an opening of the barrel and having a pressure adjusting mechanism.   The syringe container according to claim 1, wherein the pressure adjusting mechanism is at least one selected from the group consisting of a through hole, a seal, a check valve, and a diaphragm. The syringe container according to claim 1 or 2, wherein the syringe container is a container for storing the liquid agent below freezing point .