JP5548420B2 - Heating tool - Google Patents

Description

  The present invention relates to a heating tool that is applied to a human body to impart warmth.

  The present applicant has previously proposed a water vapor generator comprising a metal powder, a salt, and water and having a water vapor generating composition that releases water vapor as the metal powder is oxidized (see Patent Document 1). In this water vapor generating composition, a cosmetic ingredient or a drug ingredient is dispersed. According to this water vapor generator, there is an advantage that the cosmetic component or the drug component can be continuously supplied to the wearer's skin together with the hot water vapor. As cosmetic ingredients and pharmaceutical ingredients, fragrance ingredients such as essential oils and menthol, plant extracts and the like are used. When these components are water-insoluble, they are dispersed in water together with a dispersant such as a surfactant and emulsified and added to the water vapor generating composition.

JP 2001-187727 A

However, simply dispersing with a dispersant may require time to develop the effects of the above components. Moreover, the effect may not be enough.
The subject of this invention is providing the heating tool with which the effect of a chemical | medical agent component is more easily exhibited than the prior art mentioned above.

  The inventors of the present invention have made extensive studies on the emulsification / dispersibility of the drug in the exothermic part and its release property. When the transdermally absorbable drug is added to the exothermic part together with two specific solubilizers and surfactants. , The emulsification and dispersibility of the transdermally absorbable drug is improved, the transdermally absorbable drug is uniformly distributed in the exothermic composition, and the inhibition of fever by the transdermally absorbable drug, the dissolving agent and the surfactant is minimized. It has been found that the exothermic temperature can be maintained satisfactorily. Furthermore, the emulsified state of the percutaneously absorbable drug is moderately destabilized when the heating tool is used, so that it has been found that good release of the percutaneously absorbable drug can be achieved.

That is, the present invention is a heating tool having a heat generating part containing an oxidizable metal, a transdermally absorbable drug, a solubilizer of the drug, a surfactant, and water, and the solubilizer includes:
A) 1st solubilizer which consists of 1 or 2 sorts or more liquid oil agent chosen from the group which consists of hydrocarbon oil, ester oil, monohydric alcohol, fatty acid, silicone oil, glyceride, and vegetable oil, and B) A heating tool containing a second solubilizing agent made of a polyhydric alcohol is provided.

  According to the present invention, the release property to the skin from the transdermally absorbable drug caused by the heat generated in the heat generating portion is remarkably improved, and the physiological action of the drug can be effectively imparted. Further, the heat generation temperature can be made uniform over the entire heat generation section, and the heat generation temperature can be maintained at a constant temperature.

FIG. 1 is a plan view showing a steam heating tool as an embodiment of the heating tool of the present invention. 2 (a) and 2 (b) are explanatory views showing the usage state of the steam heating device shown in FIG. 3 is an exploded perspective view of the steam heating device shown in FIG. FIG. 4 is a plan view showing the positional relationship between the joining portion of two sheets by the joining means and the heating element. FIG. 5A is a cross-sectional view taken along the line Va-Va in FIG. 4, and FIG. 5B is a cross-sectional view taken along the line Vb-Vb in FIG. FIG. 6 is a partially broken perspective view showing a heating element in the steam heating tool shown in FIG. FIG. 7 is a conceptual diagram of the medicine discharge amount measuring apparatus.

  The present invention will be described below based on preferred embodiments with reference to the drawings. FIG. 1 is a plan view showing a steam heating tool as an embodiment of the heating tool of the present invention. The steam heating tool 1 according to the present embodiment is roughly composed of a bag body 10 and a heating element 20, and the heating element 20 is accommodated in the bag body 10. The steam heating device 1 is used for continuously supplying water vapor and a transdermally absorbable medicine heated to a predetermined temperature generated from a heat generating part included in the heat generating body 20 to a wearer's wearing site. .

  In addition, the steam heating tool 1 of this embodiment may have a shape in which two steam heating tools are connected as shown in FIG. In this case, it is used in a state where the two are connected as shown in FIG. 2 (a), or separated and directly attached to the wearer's body as shown in FIG. 2 (b). For separation, a linear cut (slit) 15 (see FIG. 1) or a perforation (not shown) may be provided along the longitudinal center line L of the bag body 10.

  FIG. 3 is an exploded perspective view of the steam heating device of FIG. The bag 10 includes a first sheet 11 located on the side close to the wearer's skin and a second sheet 12 located on the side far from the wearer's skin. The two sheets 11 and 12 have the same shape and are substantially rectangular with long sides and short sides. The two sheets 11 and 12 are overlapped with each other, and their peripheral portions are joined by the joining means 13 to form the bag body 10 having a space inside. As the joining means 13, for example, various adhesives such as a hot-melt pressure-sensitive adhesive, heat seal, ultrasonic seal and the like are used. As the sheets 11 and 12, there is no particular limitation on the type thereof as long as it has air permeability and preferably stretchability. However, since the first sheet 11 touches the wearer's body directly, it has a texture. Is preferably made of a good material. Specifically, polyesters such as PET (polyethylene terephthalate), polyolefins such as PE (polyethylene) and PP (polypropylene), synthetic fibers such as polyamide and polyacrylic; natural fibers such as cellulose, silk, cotton and wool; Examples thereof include fiber sheets made from composite fibers and the like. In particular, an air-through nonwoven fabric or a spunbond nonwoven fabric containing elastic fibers is preferable.

  The heating element 20 is used to apply water vapor heated to a predetermined temperature generated from the heating unit 21 included in the heating element 20 to the wearer's body through the bag body 10. The heating element 20 has a substantially square shape. The heating element 20 is accommodated in the space in the bag body 10 described above. In this case, the heating element 20 is accommodated in the bag body 10 so that each side thereof faces the long side and the short side of the bag body 10.

  As shown in FIG. 1, the size of the bag body 10 is larger than the size of the heating element 20, and the two sheets 11, 12 constituting the bag body 10 extend outward from the periphery of the heating element 20. . In the present embodiment, a substantially square heating element 20 is accommodated in a substantially rectangular bag body 10, but the shape of the bag body 10 and the heating element 20 may be similar. Moreover, these can also take various shapes, such as circular shape, elliptical shape, a rectangular shape, a substantially rhombus shape, a broad bean shape, for example.

  As shown in FIG. 3, fixing means 2 for fixing the steam temperature heating tool 1 to the user's body is provided on the surface of the first sheet 11 in the bag body 10 of the steam temperature heating tool 1. The fixing means 2 is present with a predetermined width over the entire periphery of the four sides of the first sheet 11. As the fixing means 2, for example, an adhesive such as a hot melt pressure-sensitive adhesive can be used.

  4 and FIGS. 5A and 5B show the positional relationship between the heating element 20 and the joining portion of the two sheets 11 and 12 by the joining means 13. As shown in FIG. 4, the joining means 13 is present with a predetermined width over the entire periphery of the four sides of the two sheets 11 and 12. As shown in FIGS. 4 and 5A, the heating element 20 is disposed so that only the upper side and the lower side overlap the joining means 13. Therefore, only the upper side and the lower side of the heating element 20 are joined to the joining means 13, and the other parts of the heating element 20 are the two sheets 11, 12, as shown in FIG. It is in a non-bonded state.

  When the bag body 10 has stretchability, the heating element 20 is fixed to the inner surface of the bag body 10 in such a manner that the stretchability of the bag body 10 is not impaired. Specifically, as shown in FIG. 4 described above, the heating element 20 is fixed to the bag body 10 at the upper side and the lower side. This prevents the heating element 20 from being displaced in the bag 10 while the steam heating tool 1 is being carried or while the steam heating tool 1 is attached to the wearer's body. Therefore, the heating element 20 stays at a site where water vapor is desired. As long as the stretchability of the bag body 10 is not impaired, the fixing position of the bag body 10 and the heating element 20 is not particularly limited to the form shown in FIG. 4, but when the steam heating device 1 is viewed in plan, the bag body 10. It is preferable that the bag body 10 is fixed so that the bag body 10 can be expanded and contracted at the portion where the heating element 20 and the heating element 20 overlap each other, because the bag 10 can have a large stretch margin.

  FIG. 6 is a perspective view showing a state in which the heating element 20 accommodated in the bag body 10 is partially cut away. The heating element 20 includes a heating part 21 and a housing 22 that houses the heating part 21. The container 22 is flat and forms the contour of the heating element 20. The container 22 is formed by bonding a plurality of sheet materials to form a bag-like space in which the heat generating portion 21 is accommodated. The container 22 having a flat shape has a first surface 23 located on the side close to the skin of the wearer and a second surface 24 located on the side farther from the user's skin opposite to the first surface 23. doing.

  The exothermic part 21 is a part that generates water vapor heated to a predetermined temperature and releases a transdermally absorbable drug using heat generated by an oxidation reaction caused by contact of an oxidizable metal with oxygen. In the present invention, the exothermic part 21 contains a transdermally absorbable drug, a solubilizing agent for the drug, a surfactant, a reaction accelerator and an electrolyte in addition to the oxidizable metal and water. Hereinafter, each agent will be described.

<About oxidizable metals>
In the present invention, the oxidizable metal is not particularly limited as long as it is a metal that generates heat upon receiving an oxidizing action. Examples thereof include powders and fibers of iron, aluminum, zinc, manganese, magnesium, calcium, and the like. Among these, iron powder is preferably used from the viewpoints of handleability, safety, manufacturing cost, and the like. When the oxidizable metal is a powder, the particle size is preferably 0.1 to 300 μm, and particularly those having a particle size of 0.1 to 150 μm in a ratio of 50% by mass or more of the total oxidizable metal. It is preferable to use what is contained. When the oxidizable metal is contained in the heat generating part 21 in a proportion of preferably 20 to 80% by mass, more preferably 30 to 70% by mass, particularly preferably 45 to 65% by mass, a sufficient calorific value is obtained. Secured and suitable.

《About reaction accelerator》
In the present invention, the reaction accelerator has a function as an oxygen retention / supply agent for an oxidizable metal. In particular, it is preferable to use one that acts as a moisture retaining agent. For example, activated carbon (coconut shell charcoal, charcoal powder, calendar bituminous coal, peat, lignite), carbon black, acetylene black, graphite, zeolite, perlite, vermiculite, silica and the like can be mentioned. Among these, activated carbon is preferable because it has water retention ability, oxygen supply ability, and catalytic ability.

  The particle size of the reaction accelerator is preferably 0.1 to 500 μm from the viewpoint that it can effectively contact the oxidizable metal. In particular, it is preferable to use one having a particle size of 0.1 to 200 μm and containing 50% by mass or more of the total reaction accelerator. When the reaction accelerator is contained in the exothermic part 21 in an amount of preferably 0.1 to 20% by mass, more preferably 1 to 15% by mass, and particularly preferably 3 to 10% by mass, the reaction promoting action is exerted. It is suitable for exhibiting.

About water
In the present invention, when water is contained in the heat generating portion 21 in an amount of preferably 10 to 50% by mass, more preferably 15 to 40% by mass, and particularly preferably 20 to 35% by mass, oxidation of the oxidizable metal is performed. This is preferable because not only the reaction is favorably promoted but also sufficient water vapor is generated.

《About electrolyte》
In the present invention, the electrolyte is an electrolyte that dissolves in water. In particular, it is preferable to further accelerate the oxidation reaction of the oxidizable metal, and examples thereof include sodium chloride, potassium chloride, calcium chloride, and magnesium chloride. Among these, sodium chloride is particularly preferable from the viewpoints of handleability, safety, production cost, and the like. The electrolyte is preferably contained in the heat generating portion 21 at a ratio of 0.1 to 15% by mass, more preferably 0.5 to 14% by mass, and particularly preferably 1 to 12% by mass. When contained in this proportion, even in the presence of an electrolyte, the emulsification / dispersibility of the transdermally absorbable drug in the exothermic composition by the surfactant is not hindered, and the exothermic temperature can be maintained better. Therefore, it is preferable.

<About transdermal drug>
The transdermally absorbable drug in the present invention is a substance that is released by the fever of a heating tool, absorbed from the skin, and exerts a local and whole body bioactive action, and is generally used for cosmetics and medicines. It is a skin-absorbing drug. Specifically, perfumes such as camphor, limonene, geraniol, cedrol, citronellol, essential oils such as peppermint oil, peppermint oil, lavender oil, eucalyptus oil, ginger oil, menthol such as l-menthol and dl-menthol, Cooling agents such as menthol derivatives (for example, menthyl lactate), capsicum tincture, warming agents such as nonylic acid vanillylamide, capsaicin, blood circulation promoters such as tocopherol acetate, tocopherol nicotinate and benzyl nicotinate, arbutin, kojic acid, L -Whitening agents such as ascorbic acid and L-ascorbic acid derivatives, anti-wrinkle agents such as retinol, local anesthetics such as lidocaine and tetracaine, methyl salicylate, glycol salicylate, indomethacin, diclofenac sodium, felbinac, ke Non-steroidal anti-inflammatory analgesics such as toprofen, skeletal muscle relaxants such as eperisone hydrochloride, antifungal agents such as miconazole and clotrimazole, hormonal agents such as estradiol and testosterone, antihypertensive agents such as clonidine, nitroglycerin and isosorbide nitrate Vasodilators, smoking cessation aids such as nicotine, bronchodilators such as tulobtail, antispasmodics such as scopolamine, and drugs for cancer pain such as fentanyl.

  Among them, menthol, menthol derivatives, monoterpenes such as camphor, limonene and geraniol, citronellol, sesquiterpenes such as cedrol, essential oils such as mint oil and peppermint oil, salicylic acid esters such as methyl salicylate and glycol salicylate, etc. When these drugs are released from the heating device with heat generation, the diffusion of the drug in the stratum corneum, which is a barrier layer for percutaneous absorption, is dramatically increased by the heat, which promotes percutaneous absorption. This is particularly effective.

  The transdermally absorbable drug preferably has a partition coefficient (1-octanol / water) which is an index indicating the hydrophobic hydrophilicity of the compound, that is, logPow is preferably 0.5 to 13, more preferably 1. 0-5. When logPow is within this range, the release property of the transdermally absorbable drug due to the heat generated by the heat generating part is improved, and the physiological action of the drug can be effectively imparted. That is, when the lipophilicity of the drug is high as described above, the drug release from the heat-generating part containing water is further enhanced, and the permeability to the horny layer, which is the skin barrier layer, is sufficiently achieved, and the skin is heated by heat. Absorption promoting action is improved and the effect of the drug can be sufficiently exerted.

  The molecular weight of the transdermally absorbable drug is preferably 50 to 1000, more preferably 100 to 500. When the molecular weight is within this range, the transdermally absorbable drug spreads more uniformly in the exothermic composition, and the release of the transdermally absorbable drug to the skin due to the exothermic heat of the exothermic part becomes good. The effect of promoting percutaneous absorption is improved, the effect of the drug can be sufficiently exerted, and the physiological action of the drug can be effectively imparted.

  Among these, drugs that promote blood circulation such as menthol, menthol derivatives, mint oil, peppermint oil, camphor, tocopherol acetate, tocopherol nicotinate, benzyl nicotinate, capsaicin, chili tincture, etc. have an effect of promoting blood circulation by heat. Therefore, the effect can be further enhanced, so that it is preferably used. Nonsteroidal anti-inflammatory analgesics are also preferably used because they are more effective for pain relief in combination with analgesic effects due to heat.

  In particular, when menthol such as l-menthol and dl-menthol, menthol derivatives, mint oil, peppermint oil, etc. are used, the skin feels cool while maintaining thermal effects such as blood circulation promoting effects, analgesic effects, and muscle relaxing effects. Since the heat sensation is suppressed, the usability can be dramatically improved even in an environment where it is easy to feel the heat sensation such as in summer.

  The various transdermally absorbable drugs can be used alone or in combination of two or more. The percutaneously absorbable drug is a total amount thereof, preferably 0.01 to 10% by mass, more preferably 0.1 to 10% by mass in the heat generating part 21 from the viewpoint of giving an appropriate physiological action to the wearer's body. 5% by mass, more preferably 0.5 to 3% by mass. When two or more types are used in combination, the use of menthol, menthol derivatives, peppermint oil and peppermint oil as one type increases the transdermal absorbability of the drug. More effective.

《About dissolving agent》
In the present invention, as the solubilizer, a combination of the following two kinds of solubilizers (the first solubilizer and the second solubilizer) is used. By using the first and second solubilizers together, the percutaneously absorbable drug can be sufficiently dissolved or dispersed in water, and the percutaneously absorbable drug can be satisfactorily released when the fever is heated. be able to.
A) 1st solubilizer consisting of one or two or more liquid oils at 25 ° C. selected from the group consisting of hydrocarbon oils, ester oils, monohydric alcohols, fatty acids, silicone oils, glycerides and vegetable oils B) Second solubilizer comprising a polyhydric alcohol

  The first solubilizer comprises one or two or more liquid oils at 25 ° C. selected from the group consisting of hydrocarbon oils, ester oils, monohydric alcohols, fatty acids, silicone oils, glycerides and vegetable oils. Specifically, hydrocarbon oils such as liquid paraffin and squalane, isopropyl myristate, isopropyl palmitate, cetyl 2-ethylhexanoate, octyldodecyl myristate, neopentyl glycol dicaprate, 2-hexyldecanol, 2 -Monohydric alcohols such as octyldodecanol, 2-decyltetradecanol, isostearyl alcohol, fatty acids such as isostearic acid and oleic acid, cyclic or linear such as dimethylpolysiloxane, methylphenylpolysiloxane, cyclomethicone Silicone oil, monoglyceride such as diglyceride dioleate, diglyceride such as diethylhexyl monoglyceride, glyceryl tricaprylate, tri (caprylic acid / capric acid) glycerin Glyceride, jojoba oil, macadamia nut oil, olive oil, vegetable oil such as castor oil and the like. Among these, especially monohydric higher alcohols having 16 to 22 carbon atoms have high compatibility with transdermal absorbable drugs, and therefore the transdermal absorbable drug can be uniformly incorporated in the exothermic composition in a smaller amount. . For this reason, the influence on heat generation is reduced, and generation of off-flavors or the like is not observed when the heating tool generates heat.

  The first solubilizer is preferably contained in the heat generating portion 21 in a proportion of 0.01 to 5% by mass, more preferably 0.05 to 3% by mass, and particularly preferably 0.1 to 1% by mass. A sufficient calorific value is ensured. The mass ratio of the first solubilizer and the transdermal drug (first solubilizer / transdermal drug) is preferably 0.01 to 2.0, more preferably 0.05 to 1.0. More preferably, it is 0.1-0.5.

  Examples of the polyhydric alcohol used as the second solubilizer include ethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, polyethylene glycol such as polyethylene glycol 200 and polyethylene glycol 400, polypropylene glycol, 1 , 3-propanediol and the like. Among these, polyethylene glycol is preferably used because it can effectively enhance the release property of the transdermally absorbable drug while maintaining the emulsifying dispersibility of the transdermally absorbable drug by the surfactant.

  The second solubilizer is preferably contained in the heat generating portion 21 in a proportion of 0.01 to 5% by mass, more preferably 0.05 to 3% by mass, and particularly preferably 0.1 to 2% by mass. This is preferable because a sufficient calorific value is ensured and the drug release from the heat generating portion is improved. The mass ratio of the second solubilizer to the transdermal drug (= second solubilizer / transdermal drug) is preferably 0.1 to 5, more preferably 0.5 to 3, and still more preferably. Is 1-2. By containing both solubilizing agents in this proportion, inhibition of fever is minimized, good release of the percutaneously absorbable drug due to the fever of the heat generating part is achieved, and the percutaneously absorbable drug originally has Physiological action is effectively exhibited.

  The combination of the solubilizers is selected in consideration of the compatibility between the transdermally absorbable drug and water and the degree of influence on the affinity between the surfactant and water. That is, a preferred combination of the first solubilizer and the second solubilizer is a combination using a monovalent higher alcohol as the first solubilizer and using a polyhydric alcohol as the second solubilizer. By using this combination, the emulsification of the transdermally absorbable drug and the water in the exothermic part 21 can be carried out more successfully, the inhibition of the exotherm can be minimized, and the percutaneous absorbability when the exothermic device generates heat. Good release of the drug is achieved, and the physiological action inherent in the transdermal drug is more effectively exhibited. Specifically, 2-octyldodecanol, 2-hexyldecanol and the like are particularly preferably used as the first solubilizer. On the other hand, what is particularly preferably used as the second solubilizer is polyethylene glycol, particularly polyethylene glycol having a molecular weight of 200 to 600. The solubilizer is preferably a substance that can dissolve the transdermally absorbable drug and is an organic solvent that is not harmful to the body.

<Surfactant>
In the present invention, as the surfactant, any of cationic surfactants, anionic surfactants, nonionic surfactants and amphoteric surfactants can be used as long as they can be used in cosmetics, pharmaceuticals, and the like. Can do. In particular, it is possible to successfully emulsify the aqueous electrolyte solution and the transdermally absorbable drug contained in the exothermic part 21, so that the emulsification stability is high, and the transdermally absorbable drug is released well by the exothermic heat of the exothermic part. It is advantageous to use a nonionic surfactant from the viewpoint of being able to do this and hardly inhibiting the heat generation of the heat generating portion 21.

  Nonionic surfactants include polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl allyl ether, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, fatty acid monoglyceride, poly Oxyethylene fatty acid ester, polyoxyethylene alkylamine, alkyl alkanolamide, sucrose fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene fatty acid glycerin, polyoxyethylene polyoxypropylene copolymer and the like can be used. Among these surfactants, polyoxyethylene surfactants such as polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl allyl ether, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid Esters, polyoxyethylene fatty acid esters, polyoxyethylene alkylamines, polyoxyethylene fatty acid glycerin, polyoxyethylene polyoxypropylene copolymers, etc., among them polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether, It is preferable because it interacts with the solubilizer and acts on the affinity of the surfactant with water. Among them, it is preferable to use polyoxyethylene hydrogenated castor oil or polyoxyethylene alkyl ether, especially polyoxyethylene hydrogenated castor oil having an HLB of preferably 10 to 20, more preferably 12 to 18, and more preferably 13 to 17. The HLB value was determined by Griffin's formula (J. Soc. Cosmet. Chem., 1, 311 (1949)).

  The content of the surfactant in the heat generating part 21 is preferably 0.01 to 5% by mass, more preferably 0.05 to 3% by mass, and particularly preferably 0.1 to 2% by mass. With such a content, the percutaneously absorbable drug and the solubilizing agent are more well dispersed in the exothermic composition. Therefore, the percutaneously absorbable drug can be more uniformly blended in the exothermic composition. It is preferable because the transdermal drug can be released satisfactorily by the heat generated in the heat generating portion and the influence on the heat generation is reduced. In particular, the mass ratio of the second solubilizer / surfactant is preferably 0.1 to 5, more preferably 0.5 to 2, in relation to the content of the second solubilizer. When the amount of the surfactant used is within this range, the heat generation of the heat generating portion 21 is more easily inhibited, and the emulsification stability between the transdermally absorbable drug and the water contained in the heat generating portion 21 is further increased. This is because it is high and good release of the transdermally absorbable drug is achieved.

  The heat generating part 21 takes the form of a heat generating sheet or a heat generating powder, for example. When the heat generating part 21 is a heat generating sheet, the heat generating sheet is formed on a molded sheet containing an oxidizable metal, a reaction accelerator and a fibrous material, a transdermally absorbable drug, a solubilizer for the transdermally absorbable drug, It is preferably configured by injecting a transdermally absorbable drug-containing electrolytic solution containing a surfactant, an electrolyte and water. Here, as the fibrous material, natural fibers such as cotton, kabok, wood pulp and non-wood pulp, or semi-synthetic fibers such as rayon, viscose rayon and cupra, nylon, acrylic, polyethylene, polypropylene, polystyrene, polyurethane Synthetic polymer fibers such as can be used. These fibrous materials preferably have an average fiber length of 0.1 to 50 mm, and more preferably 0.2 to 20 mm, from the viewpoint of securing the strength of the heat generating sheet and the water dispersibility of the fibrous material. Examples of the heat generating sheet include a sheet-like material obtained by wet papermaking, and a laminate formed by sandwiching heat generating powder with paper or the like. Such a heat generating sheet can be manufactured using, for example, the wet papermaking method described in Japanese Patent Application Laid-Open No. 2003-102761 related to the previous application of the present applicant, or the extrusion method using a die coater.

  On the other hand, when the heat generating portion 21 is made of a heat generating powder, the heat generating powder includes an oxidizable metal, a reaction accelerator, a transdermally absorbable drug, a solubilizer of the transdermally absorbable drug, a surfactant, an electrolyte. And it is preferable that it is comprised including water. In the case where the steam heating tool 1 is attached and used, it is preferable to use a heating sheet from the viewpoint that water vapor can be uniformly applied in any posture among the heating sheet and the heating powder. . Further, the heat generating sheet is more advantageous than the heat generating powder because the temperature distribution of heat generation can be made uniform easily and the ability to support an oxidizable metal is excellent.

  The first surface 23 of the container 22 constituting the heating element 20 has air permeability so that air and water vapor can pass therethrough. On the other hand, the second surface 24 has a lower degree of air and water vapor transmission than the first surface 23. That is, the second surface 24 is less breathable or non-breathable than the first surface 23. Whether the second surface 24 is breathable or non-breathable is appropriately selected depending on the specific application of the steam heating device 1.

  The heating element 20 is used such that the first surface 23 side faces the wearer's skin side and the second surface 24 side faces the clothing side (outside). The water vapor generated by the heat generation of the heat generating part 21 and the component for releasing the transdermally absorbable drug are applied to the skin of the wearer as the object through the container 22 and the bag body 10.

  Both the first surface 23 and the second surface 24 of the heating element 20 are made of a sheet material. The container 22 of the heating element 20 has a peripheral edge joint portion 25 having a closed shape formed by joining the peripheral edge portions of the sheet materials constituting the first surface 23 and the second surface 24 to each other. Have. The peripheral joint portion 25 is formed continuously. In the container 22, the first surface 23 and the second surface 24 are in a non-joined state at a portion inside the peripheral joint portion 25. Accordingly, a single bag-like space for accommodating the heat generating portion 21 is formed in the container 22. As shown in FIGS. 5A and 5B, the heat generating portion 21 is accommodated so as to occupy almost the entire space formed in the accommodating body 22. 5 (a) and 5 (b), the heat generating part 21 is simply accommodated in the bag-like space of the container 22, but when the heat generating part 21 is a heat generating sheet, a part of the inner surface of the container 22 and the heat generating part 21 are included. May be fixed using a bonding means such as an adhesive within a range that does not prevent heat generation.

Here, the air permeability is a value measured by JIS P8117, and is defined as the time required for 100 ml of air to pass through an area of 6.45 cm ² under a constant pressure. Therefore, a high air permeability means that it takes time to pass air, that is, the air permeability is low. Conversely, a low air permeability means high air permeability. Thus, the magnitude of the air permeability and the level of air permeability are opposite to each other. In the present embodiment, when the air permeability of the first surface 23 and the second surface 24 is compared, the first surface 23 is higher than the second surface 24. That is, as described above, the second surface 24 is non-breathable or hardly breathable (that is, it has breathability but is less breathable than the first surface 23). It is.

  The container 22 has a flat shape having a first surface 23 that is a ventilation surface and a second surface 24 that is a non-ventilation surface opposite to the first surface 23, and passes through the first surface 13 that is a ventilation surface. Steam heat is generated. Or the container 22 has the flat form which has the 1st surface 23 which is a ventilation surface, and the 2nd surface 24 which is a difficult ventilation surface facing it, and is the 1st surface which is a ventilation surface. Steam temperature and heat are generated through 23. When the second surface 24 is difficult to breathe, the air preferentially flows into the container 22 through the second surface 24 by balancing the air permeability of the first surface 23 and the second surface 24. At the same time, water vapor is preferentially released through the first surface 23.

  When the second surface 24 is difficult to breathe, the second surface 24 is vented from the viewpoint of suppressing the release of water vapor through the surface 24 while ensuring the inflow of air through the second surface 24. It is preferable that the degree is 1.5 times or more, particularly 2 times or more than the air permeability of the first surface 23. Alternatively, the ratio of the air permeability of the first surface 23 and the air permeability of the second surface 24 (first surface / second surface) is preferably 0.7 or less, particularly 0.4 or less. Thereby, the release of water vapor through the second surface 24 can be further reduced, and the release of water vapor through the first surface 23 can be further increased. On the other hand, when the second surface 24 is non-breathable, the inflow of air into the container 22 and the generation of water vapor are performed exclusively through the first surface 23.

  In the present embodiment, as described above, the heat generating portion 21 of the heat generating element 20 contains the transdermally absorbable drug, its dissolving agent, and a surfactant. Although these agents can achieve sufficient oxidation by using the specific solubilizer or surfactant of the present invention, they tend to slightly prevent oxidation of the oxidizable metal contained in the heat generating portion 21. There is a tendency for the heat generation characteristics and water vapor generation characteristics of the heat generating portion 21 to decrease. Therefore, in this embodiment, it is advantageous to promote the oxidation of the oxidizable metal by slightly increasing the air permeability of the first surface 23 as compared with the conventional steam heating tool. From this viewpoint, the air permeability of the first surface 23 is preferably 5000 to 25000 seconds / (100 ml), more preferably 8000 to 22000 seconds / (100 ml), and even more preferably 10,000 to 20000 seconds / (100 ml). . On the other hand, regarding the second surface 24, when it is difficult to breathe, it is preferable that the air permeability of the surface 24 is 30000 seconds / (100 ml) or more, particularly 40000 seconds / (100 ml) or more.

  Both the first surface 23 and the second surface 24 of the heating element 20 are made of a sheet material. As the sheet material that controls the air permeability and prevents the powder from leaking out, a melt-blown nonwoven fabric or a moisture-permeable film is preferably used. The moisture-permeable film is obtained by forming a melt-kneaded product of a thermoplastic resin and an organic or inorganic filler that is not compatible with the resin into a film shape and stretching it uniaxially or biaxially. It has a structure. By configuring a laminated sheet by combining sheet materials having various air permeability and moisture permeability, the degree of freedom for setting the air permeability of the first surface 23 and the second surface 24 to a desired value is increased.

The steam heating tool 1 is entirely packaged by a packaging material (not shown) having an oxygen barrier property before use, so that the heat generating portion 21 does not come into contact with oxygen in the air. As an oxygen barrier material, for example, the oxygen permeability coefficient (ASTM D3985) is 10 cm ³ · mm / (m ² · day · MPa) or less, particularly 2 cm ³ · mm / (m ² · day · MPa) or less. Such a thing is preferable. Specifically, a film such as an ethylene-vinyl alcohol copolymer or polyacrylonitrile, a film obtained by vapor-depositing ceramic or aluminum on such a film, or an aluminum film can be used.

  The steam heating tool 1 is manufactured by the following method, for example. When the heat generating part 21 is a powder composition, all the components constituting the heat generating part 21 may be mixed, but a preferred manufacturing method is as follows. A solid component constituting the heat generating portion 21 such as an oxidizable metal and a reaction accelerator is mixed in advance, and a percutaneously absorbable drug, a solubilizer, and a surfactant for an aqueous solution in which an electrolyte is dissolved in water. A heat-generating part 21 is obtained by preparing a percutaneously absorbable drug-containing electrolytic solution obtained by stirring and emulsifying the mixture (300 rpm, 10 minutes), and adding and mixing the percutaneously absorbable drug-containing electrolyte to the solid content. The heating element 20 can be manufactured by storing it in the container 22.

  On the other hand, when the heat generating part 21 is a molded sheet, a molded sheet containing an oxidizable metal, a reaction accelerator and a fibrous material is prepared, and then the molded sheet is prepared in the same manner as described above. The exothermic part 21 is obtained by injecting the skin-absorbing drug-containing electrolyte, and the exothermic body 20 can be manufactured by accommodating the exothermic part 21 in the accommodating body 22. By manufacturing the heating element 20 by such a method, the transdermally absorbable drug can be uniformly distributed throughout the heat generating portion 21. The obtained heating element 20 is housed in the bag body 10, whereby the steam heating tool 1 is manufactured.

  When manufactured by these methods, the surfactant, the solubilizer, the transdermally absorbable drug, and the electrolyte-containing aqueous solution are simultaneously added to the exothermic composition, so that the transdermally absorbable drug is uniformly in the exothermic composition. The fever is more stable. In particular, when the exothermic part 21 is a molded sheet, the permeability of the surfactant, the dissolving agent, the transdermally absorbable drug and the electrolyte-containing aqueous solution to the molded sheet is remarkably improved. Uniformity is improved. Moreover, heat generation can be further stabilized.

  As mentioned above, although this invention was demonstrated based on the preferable embodiment, this invention is not restrict | limited to the said embodiment. For example, the above embodiment is an example in which the heating tool of the present invention is applied to a steam heating tool. However, the present invention is known as a heating tool other than the steam heating tool, for example, a disposable body warmer. The present invention can be similarly applied to a heating tool whose amount is extremely small. In this case, since the skin blood flow is enhanced by heat, the transferability of the drug to the subcutaneous tissue is enhanced, and the effect of promoting percutaneous absorption is obtained. However, the degree to which the percutaneously absorbable drug physiologically acts on the wearer is that the skin stratum corneum, which is a barrier layer, is swollen by water vapor, and the drug penetrates through the skin. The form of heating tool is higher. For example, when a cooling sensation agent is used as the transdermally absorbable drug, the effect of enhancing the refreshing sensation due to the action of the cooling sensation agent is higher in the heating device of the above-described embodiment accompanied by the generation of steam heat.

  Moreover, in the said embodiment, although the heat generating body 20 was accommodated in the bag body 10 which has a stretching property, you may use the thing which does not have a stretching property as this bag body.

  Moreover, although the steam heating tool 1 of the said embodiment was affixed and used for a wearer's body, it replaces with this and uses the steam heating tool 1 for clothing, a mask, an eye It may be used as a mask or applied to the body by hand. When the steam heating tool 1 is attached to clothing, a fixing means made of an adhesive or the like may be provided on the surface of the second sheet 12 in the bag body 10.

  Hereinafter, the present invention will be described in more detail with reference to examples. However, the scope of the present invention is not limited to such examples. Unless otherwise specified, “%” and “part” mean “% by mass” and “part by mass”, respectively.

[Example 1]
The steam heating tool 1 according to the embodiment shown in FIGS. 1 to 6 was produced by the following procedure.
(1) Production of sheet-like heat generating part 21 <Formulation sheet raw material composition blend>
・ Oxidizable metal: Iron powder, manufactured by Dowa Mining Co., Ltd., trade name “RKH”: 83%
-Fibrous material: Pulp fiber (Fletcher Challenge Canada, product name NBKP “Mackenzi (adjusted to CSF 200 ml)”): 8%
-Reaction accelerator: activated carbon (made by Nippon Enviro Chemical Co., Ltd., trade name “Carborafine”, average particle size 45 μm) 9%

  Polyamide epichlorohydrin resin (manufactured by Seiko PMC Co., Ltd., trade name “WS4020”) based on 100 parts of the solid content (total of oxidizable metal, fibrous material and activated carbon) of the raw material composition. And 0.78 parts of sodium carboxymethylcellulose (Daiichi Kogyo Seiyaku Co., Ltd., trade name “HE1500F”) as an anionic flocculant was added. The slurry was added until the concentration reached 12%.

<Making conditions>
Using the slurry, it was diluted with water to 0.3% just before the paper making head, and paper was made at a line speed of 15 m / min with an inclined short paper machine to produce a wet shaped sheet.

<Drying conditions>
The molded sheet was sandwiched with felt and dehydrated under pressure, passed through a heating roll at 140 ° C. as it was, and dried until the water content became 5% or less. The basis weight after drying was 450 g / m ² and the thickness was 0.45 mm. The composition of the molded sheet thus obtained was measured using a thermogravimetric measuring apparatus (TG / DTA6200, manufactured by Seiko Instruments Inc.), and as a result, it was 83% iron, 9% activated carbon, and 8% pulp.

<Injection of transdermal drug-containing electrolyte into molded sheet>
The obtained molded sheet was cut into 49 mm × 49 mm, three sheets were stacked, and 45 parts of menthol-containing electrolyte prepared with the composition shown in Table 1 below was injected into 100 parts of the molded sheet. The ratio of menthol to the total mass of the heat generating part 21 is 0.9%, the ratio of 2-octyldodecanol is 0.2%, the ratio of polyethylene glycol is 1.4%, and polyoxyethylene hydrogenated castor oil (60 EO ) (HLB14.0) was 0.9%. These were permeated into the entire molded sheet by utilizing capillary action to obtain a rectangular sheet-shaped heating part 21.

(2) Production of Heating Element 20 The first surface 23 and the second surface 24 of the container 22 were composed of the following films to obtain the heating element 20. The heating element 20 was accommodated in a bag 10 made of the following elastic sheets 11 and 12. A hot melt pressure-sensitive adhesive made of a SIS copolymer was used for fixing the sheets 11 and 12 and the heating element 20. Furthermore, the fixing means 2 of the hot-melt adhesive which consists of a SIS copolymer was provided in the surface of the 1st elastic sheet 11. FIG. Thus, the steam heating tool 1 was obtained.

The first surface 23 of the container 22 was made of a polyethylene moisture-permeable film having an air permeability of 15000 seconds / 100 ml, and the second surface 24 was made of a polyethylene moisture-permeable film having an air permeability of 60000 seconds / 100 ml. The stretchable sheet 11 in the bag body 10 was composed of a polyethylene terephthalate nonwoven fabric having a basis weight of 38 g / m ² , and the stretchable sheet 12 was composed of a polypropylene nonwoven fabric having a basis weight of 50 g / m ² .

[Comparative Example 1]
A menthol-containing electrolyte solution was prepared with the composition shown in Table 2 below, and a steam heating tool was produced in the same manner as in Example 1.

[Evaluation 1]
For the steam heating devices of Example 1 and Comparative Example 1, the amount of menthol released from the sheet with heat generation was quantified using the following drug release amount measuring device. As a result, as shown in Table 3, 1.9 mg of menthol was recovered in 2 hours from the steam heating device of Example 1 containing polyethylene glycol as the second solubilizer, whereas Comparative Example 1 1.0 mg of menthol was recovered from the steam heater. As apparent from the results in Table 3, the steam heating device using the present invention was found to have a high menthol release property.

<Discharge amount measuring device>
As shown in FIG. 7, the steam heating tool 1 of Example 1 or Comparative Example 1 was sealed in a vinyl fluoride resin bag body (for example, Tedlar bag) 31 on a hot plate 30 heated to 35 ° C. One end of two pipes 32 and 33 is connected to the bag body 31 of vinyl fluoride resin. The other end of the pipe 32 is connected to an air supply source (not shown) via a flow meter 34. The other end of the tube 33 is immersed in a container 35 containing ethanol. The bag body 31 of vinyl fluoride resin is covered with a nonwoven fabric 36 made of polypropylene to insulate it. In addition, a weight 37 was placed on the nonwoven fabric 36 so that the steam heating tool 1 did not move when air was introduced into the bag body 31 of the vinyl fluoride resin. While letting air flow in from the air supply source (not shown) through the tube 32 into the bag body 31 of vinyl fluoride resin (100 ml / min), the gas released with heat generation is passed through the tube 33. Menthol was recovered in ethanol by draining into ethanol. The recovered amount after 2 hours was quantified by gas chromatography (“6890N Network GC system” from “Agilent Technologies”). In addition, the steam heating tool 1 enclosed in the bag body 31 of a vinyl fluoride resin is one thing which cut | disconnected the steam heating tool 1 which two shown in FIG. 1 connected.

[Evaluation 2]
Using the steam heating tools of Example 1 and Comparative Example 1, a sticking test on the left and right shoulders was performed. Evaluate the speed and strength of a refreshing feeling after applying the steam heating tool of Example 1 to the left or right shoulder of 10 subjects and the steam heating tool of Comparative Example 1 to the remaining one side for 6 hours. did. The results are shown in Table 4. As is clear from the results in Table 4, in the present invention, due to the high release of menthol, it had a remarkably high refreshing feeling derived from menthol.

[Examples 2 to 11]
A steam heating tool was obtained in the same manner as in Example 1 except that the ratio of the components constituting the heat generating portion was as shown in Table 5 below. The obtained steam heating tool was attached to the shoulders of five panelists. Panelists were allowed to evaluate the refreshing sensation, odor (unpleasant odor other than menthol incense) and comprehensive evaluation in the attached state according to the following criteria. The evaluation with the largest number of people is selected and shown in Table 2. In the table, the evaluation results of Example 1 and Comparative Example 1 are also shown.

〔Sensation of coolness〕
6: A very strong and refreshing feeling is felt.
5: A very favorable refreshing feeling is felt.
4: A moderate refreshing feeling is felt.
3: A refreshing feeling is slightly weak.
2: The refreshing feeling is too weak.
1: Does not feel cool.

〔odor〕
A: No odor is felt.
○: A weak odor is felt.
X: A strong odor is felt.

〔Comprehensive evaluation〕
A: Very comfortable in a hot environment.
○: Comfortable in a hot environment.
Δ: Not very comfortable in a hot environment.
×: Not comfortable in a hot environment.

  As is clear from the results shown in Table 5, it was found that the steam heating tool of each example can impart a refreshing sensation to the user and the generation of off-flavor is suppressed. In contrast, the steam heating tool of Comparative Example 1 was found to have a very low effect of imparting a refreshing feeling to the user, although no off-flavor was generated.

1 Steam heating tool (heating tool)
DESCRIPTION OF SYMBOLS 10 Bag body 11 1st elastic sheet 12 2nd elastic sheet 20 Heat generating body 21 Heat generating part 22 Container 23 First surface 24 Second surface

Claims (6)

A heating tool having a heating part containing an oxidizable metal, a reaction accelerator, a transdermally absorbable drug, a solubilizer of the drug, a surfactant, an electrolyte, and water,
The solubilizer is
A) 1st solubilizer which consists of 1 or 2 sorts or more liquid oil agent chosen from the group which consists of hydrocarbon oil, ester oil, monohydric alcohol, fatty acid, silicone oil, glyceride, and vegetable oil, and B) containing a second solubilizer comprising a polyhydric alcohol ,
First dissolving agent is 0.01 to 5 mass% in the heating unit, heating tool Ru second dissolving agent is 0.01 to 5 mass% in the heat generating portion.   The heating tool according to claim 1, wherein the mass ratio of the first solubilizer to the transdermal drug (first solubilizer / transdermal drug) is 0.01 to 2.0.   The heating tool according to claim 1 or 2, wherein a mass ratio of the second solubilizer to the transdermal drug (second solubilizer / transdermal drug) is 0.1 to 5.0.   The transdermally absorbable drug contains one or more transdermally absorbable drugs selected from the group consisting of l-menthol and dl-menthol, derivatives thereof, peppermint oil, and peppermint oil. The heating tool according to any one of 3 above.   The heating tool according to any one of claims 1 to 4, wherein the second solubilizer is polyethylene glycol.   The heating tool according to any one of claims 1 to 5, wherein the surfactant is a nonionic surfactant.

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