JP5485294B2 - Ｊａｋ経路の阻害のための組成物および方法 - Google Patents

Ｊａｋ経路の阻害のための組成物および方法 Download PDF

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Publication number
JP5485294B2
JP5485294B2 JP2011543688A JP2011543688A JP5485294B2 JP 5485294 B2 JP5485294 B2 JP 5485294B2 JP 2011543688 A JP2011543688 A JP 2011543688A JP 2011543688 A JP2011543688 A JP 2011543688A JP 5485294 B2 JP5485294 B2 JP 5485294B2
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Japan
Prior art keywords
substituted
alkyl
heterocyclyl
cycloalkyl
methyl
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JP2011543688A
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Japanese (ja)
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JP2012513480A (ja
JP2012513480A5 (https=
Inventor
ソーマセハル バーミジパチ
ホイ リー
ラジンデル シング
ヴァネッサ テイラー
ジェフリー クロフ
ダレン マクマートリー
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ライジェル ファーマシューティカルズ， インコーポレイテッド
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Publication of JP2012513480A5 publication Critical patent/JP2012513480A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011543688A 2008-12-23 2009-12-23 Ｊａｋ経路の阻害のための組成物および方法 Expired - Fee Related JP5485294B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14060408P 2008-12-23 2008-12-23
US61/140,604 2008-12-23
US12/645,349 US8268851B2 (en) 2008-12-23 2009-12-22 Compositions and methods for inhibition of the JAK pathway
US12/645,349 2009-12-22
PCT/US2009/069480 WO2010075558A2 (en) 2008-12-23 2009-12-23 Compositions and methods for inhibition of the jak pathway

Publications (3)

Publication Number Publication Date
JP2012513480A JP2012513480A (ja) 2012-06-14
JP2012513480A5 JP2012513480A5 (https=) 2013-05-09
JP5485294B2 true JP5485294B2 (ja) 2014-05-07

Family

ID=42266455

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011543688A Expired - Fee Related JP5485294B2 (ja) 2008-12-23 2009-12-23 Ｊａｋ経路の阻害のための組成物および方法

Country Status (6)

Country Link
US (2) US8268851B2 (https=)
EP (1) EP2370415B1 (https=)
JP (1) JP5485294B2 (https=)
CA (1) CA2745901C (https=)
ES (1) ES2583642T3 (https=)
WO (1) WO2010075558A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
CA2642229C (en) * 2006-02-24 2015-05-12 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US8268851B2 (en) 2008-12-23 2012-09-18 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
WO2014091265A1 (en) * 2012-12-11 2014-06-19 Aurigene Discovery Technologies Limited Pyrimidine-2,4-diamine derivatives as kinase inhibitors
KR101665301B1 (ko) 2013-08-07 2016-10-11 카딜라 핼쓰캐어 리미티드 야누스 키나제의 억제제로서 n-시아노메틸아미드
EP3206691B1 (en) * 2014-10-14 2018-09-19 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use
US9737683B2 (en) 2015-05-07 2017-08-22 Aladdin Dreamer, Inc. Lucid dream stimulator, systems, and related methods
US10300240B2 (en) 2015-05-07 2019-05-28 Aladdin Dreamer, Inc. Lucid dream stimulator, systems, and related methods
WO2020092015A1 (en) 2018-11-02 2020-05-07 University Of Rochester Therapeutic mitigation of epithelial infection
WO2020257495A1 (en) * 2019-06-18 2020-12-24 Purdue Research Foundation Inhibitors of erythrocyte band 3 tyrosine phosphorylation and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
EP2089369B1 (en) * 2006-10-19 2011-02-02 Rigel Pharmaceuticals, Inc. 2,4 -pyrimidinediamine derivatives as inhibitors of jak kinases for the treatment of autoimmune diseases
US7947698B2 (en) 2007-03-23 2011-05-24 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
WO2008118823A2 (en) 2007-03-26 2008-10-02 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US8268851B2 (en) * 2008-12-23 2012-09-18 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway

Also Published As

Publication number Publication date
US8420659B2 (en) 2013-04-16
CA2745901C (en) 2017-03-14
US20120301486A1 (en) 2012-11-29
ES2583642T3 (es) 2016-09-21
WO2010075558A2 (en) 2010-07-01
HK1162483A1 (zh) 2012-08-31
EP2370415B1 (en) 2016-04-20
US20100158921A1 (en) 2010-06-24
JP2012513480A (ja) 2012-06-14
CA2745901A1 (en) 2010-07-01
EP2370415A4 (en) 2012-09-12
US8268851B2 (en) 2012-09-18
EP2370415A2 (en) 2011-10-05
WO2010075558A3 (en) 2010-11-04

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