JP5432281B2 - 電離放射線治療用スペーサー及びこれを作製するための、繊維集合体を含むシート - Google Patents
電離放射線治療用スペーサー及びこれを作製するための、繊維集合体を含むシート Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
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- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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- G—PHYSICS
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- G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
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- A—HUMAN NECESSITIES
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- G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
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Description
1.生体適合性の合成高分子材料からなる繊維状物を三次元的に交絡した繊維集合体を含む電離放射線治療用スペーサーであって、水分を含むことで放射線を遮断する機能を有し、含水した状態の重量基準含水率が90%以上であることを特徴とする、電離放射線治療用スペーサー。
2.生体適合性の合成高分子材料が、生体吸収性合成高分子材料である、前項1に記載の電離放射線治療用スペーサー。
3.繊維集合体の厚みが5mm〜15mmである前項1又は2に記載の電離放射線治療用スペーサー。
4.前項1〜3のいずれか1に記載の電離放射線治療用スペーサーを作製するための、繊維集合体を含むシート。
A=〔W/(W+V)〕×100
図1は、本発明にかかる電離放射線治療用スペーサーを示す斜視図解図である。実施例1では、生体適合性の合成高分子材料からなる繊維状物として、合成吸収性縫合糸であるオペポリックス(R)(アルフレッサファーマ社製)を使用した。この縫合糸は、ペレットから引き出した繊維を3本撚り合わせて作製したマルチフィラメント糸である。この糸には、クリンプ加工は施されておらずストレートタイプの糸である。この糸はポリグリコール酸からなるので生体内に留置した場合には、加水分解されて糸の抗張力が約3週間で半減し、さらに約3ヶ月後には糸の形態が無くなり生体に吸収される。したがって、この糸は生体吸収型の生体適合性を有するものである。実施例1の電離放射線治療用スペーサーを作製するために、この糸を長さ約50mmにカットしたものを多数準備し、これら糸からカーディング装置を使って繊維ウェブを作製した。作製したウェブにニードルパンチ加工を施して図2に示すように糸を三次元的に交絡させ、目付け0.0716g/cm2、見かけ密度0.0716g/cm3で、厚み10mmの不織布を作製した。そして、この不織布を15cm角の矩形状に切り出して実施例1とした。以下、本実施例で作製したスペーサーを「不織布スペーサー」という。図3に示すように、本実施例の不織布スペーサーは無数の細かい空隙が連通した状態で形成されており、表面には空隙が露出した状態に形成されている。これにより、本実施例の不織布スペーサーは、毛細管現象の作用により生理食塩水や腹腔内の液体などと接触したとき、瞬時にそれらの液体を吸液し保液される。
比較例として、組織補強材料として販売されているソフトティッシュパッチ(品番13150S:150mm×200mm×2.0mm)を用いた。
実施例1で作製した不織布スペーサーと比較例1のゴアテックス(R)スペーサーの含水性を計測するため、以下の手順で試験を行った。
試験方法:
1.試験サンプルとして実施例1と比較例1とをそれぞれ5cm角の矩形状に切り出し、シャーレの上に静置した。
2.試験サンプルの縁にスポイトで水を滴下していき、シャーレの底に水が染み出てきたときの滴下水量を計量し、保水量とした。
その結果を表1に示した。
1)スペーサー水等価厚の測定
実施例1で作製した本発明のスペーサーを2枚重ねたもの及び比較例1としてのゴアテックス(R)スペーサーを2枚重ねたもの(厚み4mm)について、通常の粒子線治療と同様にCT撮影し、治療計画装置で求めた水等価厚(計測値)と粒子線ビームを使って実測より求めた水等価厚(実測値)との比較を行った。ここで、水等価厚とは、遮蔽体の放射線の阻止能を示す指標となるものであり、遮蔽体の遮蔽能力を水の場合に換算した場合の厚み(遮蔽体に含まれる水媒体の厚みに等しい)をいう。その結果を表2に示した。本発明のスペーサーは、糸を三次元的に交絡させて形成したシートであり、その水等価厚は、ほぼ空気に近い値であった。本発明のスペーサーについて、乾燥状態では粒子線のビームを止める事ができないことが示唆された。
ここでは、実施例1で作製した本発明のスペーサーについて、乾燥状態及び吸水した状態での水等価厚を測定した。その結果を表3に示した。乾燥状態では水等価厚が0.5mmであったが、吸水後水等価厚は11.6mmとなり、乾燥状態の約23倍であった。また、単位厚さあたりで計算した場合では、乾燥状態では0.05mm、吸水後は1.16mmであった。このことから、実施例1で作製した本発明のスペーサーは、吸水することで、高い遮蔽性能を発揮することが示されている。なお、吸水時にスペーサーの水等価厚が乾燥状態のスペーサーの厚みより厚い値となったのは、高い吸水力により吸水したことでスペーサーが膨張したことに起因すると考えられる。
Claims (4)
- 生体適合性の合成高分子材料からなる繊維状物を三次元的に交絡した繊維集合体を含む電離放射線治療用スペーサーであって、水分を含むことで放射線を遮断する機能を有し、含水した状態の重量基準含水率が90%以上であることを特徴とする、電離放射線治療用スペーサー。
- 生体適合性の合成高分子材料が、生体吸収性合成高分子材料である、請求項1に記載の電離放射線治療用スペーサー。
- 繊維集合体の厚みが5mm〜15mmである請求項1又は2に記載の電離放射線治療用スペーサー。
- 請求項1〜3のいずれか1に記載の電離放射線治療用スペーサーを作製するための、繊維集合体を含むシート。
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JP2011539349A JP5432281B2 (ja) | 2009-11-05 | 2010-10-28 | 電離放射線治療用スペーサー及びこれを作製するための、繊維集合体を含むシート |
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PCT/JP2010/069124 WO2011055670A1 (ja) | 2009-11-05 | 2010-10-28 | 電離放射線治療用スペーサー |
JP2011539349A JP5432281B2 (ja) | 2009-11-05 | 2010-10-28 | 電離放射線治療用スペーサー及びこれを作製するための、繊維集合体を含むシート |
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JP2013251642A Pending JP2014064940A (ja) | 2009-11-05 | 2013-12-05 | 電離放射線治療用スペーサー及びこれを作製するための、繊維集合体を含むシート |
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EP3088046B1 (en) * | 2013-12-27 | 2018-08-15 | National University Corporation Gunma University | Implantable spacer |
EA201790839A1 (ru) * | 2014-10-14 | 2017-08-31 | Антонио Самбуссети | Абсорбируемое устройство для регенерации кости |
WO2017158965A1 (ja) | 2016-03-14 | 2017-09-21 | 株式会社リコー | ボーラス及びその製造方法 |
JP2018042855A (ja) * | 2016-09-15 | 2018-03-22 | 国立大学法人神戸大学 | 放射線治療用スペーサー |
CN111569277B (zh) * | 2020-05-13 | 2022-02-18 | 戴建荣 | 放疗靶区隔离体 |
CN116440428B (zh) * | 2023-06-12 | 2023-08-22 | 北京普朗盾医疗科技有限公司 | 一种植入式可在体内反复充放的组织隔离装置 |
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US20120271093A1 (en) | 2012-10-25 |
KR102070986B1 (ko) | 2020-01-29 |
EP2497534A1 (en) | 2012-09-12 |
JPWO2011055670A1 (ja) | 2013-03-28 |
KR20120095917A (ko) | 2012-08-29 |
US10525281B2 (en) | 2020-01-07 |
CN102596317A (zh) | 2012-07-18 |
EP2497534A4 (en) | 2013-04-17 |
JP2014064940A (ja) | 2014-04-17 |
KR20180012346A (ko) | 2018-02-05 |
EP2497534B1 (en) | 2016-08-10 |
WO2011055670A1 (ja) | 2011-05-12 |
CN102596317B (zh) | 2014-12-03 |
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