JP5427620B2 - Blood pump flow estimation method - Google Patents

Description

  The present invention relates to a blood pump flow rate estimation method, a flow rate estimation information creation method, and general flow rate estimation information creation method.

As one method for treating severe heart disease, treatment using an implantable blood pump is performed. In order to appropriately perform such treatment, it is necessary to accurately know the flow rate of the blood pump. Therefore, thermodilution blood flow meter, dye dilution method blood flow meter, electromagnetic blood flow meter, ultrasonic blood flow meter, transesophageal echo blood flow meter, transthoracic echo blood flow meter, electrical impedance method A blood flow meter such as a blood flow meter is installed outside and inside a patient to measure the flow rate of an implantable blood pump.
However, blood flowmeters such as thermodilution blood flowmeters, dye dilution blood flowmeters, electromagnetic blood flowmeters, and ultrasonic blood flowmeters must be installed in the patient's body. The burden is also great. For this reason, these blood flow meters can be installed in the patient's body only for a certain period of time after the operation. After that, a method of knowing the flow rate of the blood pump without using these blood flow meters Is required.
In addition, blood flow meters such as blood flow meters using transesophageal echoes, blood vessels using transthoracic echoes, and blood flow meters using the electrical impedance method are actually cumbersome for blood flow measurement and burden the patient. Since it is large, a method for knowing the flow rate of the blood pump without using these blood flow meters is also required.

14 and 15 are views for explaining a conventional blood pump system for satisfying such a requirement.
As shown in FIGS. 14 and 15, the conventional blood pump system 901 includes a blood pump 905 that rotates the impeller 921 using the rotational force of the motor 934 as a driving source, and supplies blood, and a plurality of different blood liquids having different predetermined liquid viscosities. A viscosity rotation number motor current discharge flow rate related data storage unit 960 that stores predetermined viscosity related discharge flow rate data composed of a plurality of motor current discharge amount related data of the impeller rotation number for a plurality of different predetermined viscosities, a blood parameter input unit 957, A sensor circuit 955 serving as an impeller rotational speed measurement / calculation function for measuring the rotational speed of the impeller 921, a motor current value measuring function for measuring a current supplied to the motor 934, a liquid viscosity, an impeller rotational speed, a motor current, and a viscosity Rotation speed motor current discharge flow rate related data (predetermined viscosity related discharge flow rate data table. FIG. Irradiation. Liquid viscosity with), and a discharge flow rate computation unit 958 for calculating the liquid discharge flow from the motor current and the impeller rotation speed.

Therefore, according to the blood pump system 901, as shown in FIGS. 14 and 15, the impeller rotational speed, the motor current and the blood viscosity are measured, and based on these measured values and the predetermined viscosity related discharge flow rate data table. Since the blood discharge flow rate is calculated, the flow rate of the blood pump can be estimated without using a blood flow meter.
Further, according to the blood pump system 901, as shown in FIGS. 14 and 15, the blood discharge flow rate is calculated based on the predetermined viscosity-related discharge flow rate data table, that is, the minimum required to satisfy the required accuracy. Since individual data is stored as a data table and blood discharge flow rate is calculated using data close to the current value to be calculated, etc., from the relational expression of impeller rotation speed, motor current, blood viscosity and blood pump flow rate It is said that an accurate flow rate can be easily obtained as compared with the case of calculating the blood discharge flow rate (see, for example, Patent Document 1).

Japanese Patent Laid-Open No. 2003-210572

  However, in an implantable blood pump, it is not easy to eliminate individual differences in blood pump characteristics due to structural limitations. Therefore, when the flow rate of such a blood pump is estimated using the method of the conventional blood pump system 901 described above, the estimation accuracy of the flow rate of the blood pump is reduced due to individual differences in blood pump characteristics. For this reason, there is a problem that treatment using an implantable blood pump cannot be performed properly.

  Therefore, the present invention has been made to solve such a problem, and it is possible to effectively suppress the deterioration of the accuracy of the flow rate estimation result due to individual differences in blood pump characteristics. It aims to provide a method. It is another object of the present invention to provide a method for creating a flow rate estimation method and a method for creating general flow rate estimation information used to implement the flow rate estimation method for a blood pump of the present invention.

(1) In the blood pump flow rate estimation method of the present invention, the blood pump flow rate Q in a blood pump that feeds blood using the rotational force of the motor as a drive source, the motor rotation speed N, the motor current consumption I, and the patient Blood flow rate estimation method based on blood blood attribute data Z, which describes the relationship among motor rotation speed, motor current consumption, blood pump flow rate, and liquid attribute data in the actual blood pump A first step of creating information, and measuring a rotational speed N of the motor and current consumption I of the motor and attribute data Z of the blood of the patient in the blood pump embedded in the patient's body, and the flow rate estimation information and these And a second step of estimating the flow rate Q of the blood pump based on the values N, I and Z.

  Therefore, according to the blood pump flow rate estimation method of the present invention, in the first step, flow rate estimation information is created for each blood pump actual machine that will perform flow rate estimation, and in the second step, this flow rate estimation information. Therefore, the accuracy of the flow rate estimation result is not deteriorated due to individual differences in blood pump characteristics, and the object of the present invention is achieved.

In the blood pump flow rate estimation method of the present invention, the “blood pump actual machine” refers to a blood pump to be subjected to flow rate estimation.
In addition, “a plurality of blood pumps” to be described later measures or evaluates the characteristics of the blood pump (general flow rate estimation information to be described later) among blood pumps of the same standard and model number as the “blood pump actual machine” in advance. Any multiple blood pumps.

  In the blood pump flow rate estimation method of the present invention, “liquid” refers to a fluid that flows to the blood pump when creating flow rate estimation information, and in the case of “test fluid” and “patient blood”. There are cases.

(2) In the blood pump flow rate estimation method described in (1) above, the flow rate estimation information is preferably a flow rate estimation formula.
By adopting such a method, by substituting the rotational speed N of the motor, the current consumption I of the motor measured in the second step, and the attribute data Z of the blood of the patient into this flow rate estimation formula, The blood pump flow rate can be estimated.

(3) In the blood pump flow rate estimation method described in (1) above, the flow rate estimation information is preferably a flow rate estimation table.
By adopting such a method, it is possible to refer to the corresponding portion of the flow rate estimation table that approximates the motor rotation speed N, the motor current consumption I, and the patient blood attribute data Z measured in the second step and is appropriate. By performing the complementary calculation, it is possible to easily estimate the flow rate of the blood pump.

(4) In the blood pump flow rate estimation method according to any one of (1) to (3), the first step includes motor rotation speed, motor current consumption, and test liquid attributes in the blood pump actual machine. Preferably, the flow rate estimation information is created by measuring the flow rate of the blood pump when the data is changed using a flow meter.

The step of creating the flow rate estimation information is a step that is inherently complicated and time-consuming. This is because in order to create the flow rate estimation information, it is necessary to measure the flow rate of the blood pump by changing the motor rotation speed, the motor current consumption, and the liquid attribute data.
However, according to the method for estimating the flow rate of the blood pump described in (4) above, the flow rate estimation information is created using the test solution, and thus the first step, which is complicated and laborious, is performed before shipping. You will be able to finish it.
In addition, since the first step, which is complicated and time-consuming, can be performed before the blood pump device is implanted in the patient's body, the burden on the patient does not increase.
Furthermore, if the flow rate estimation information is created for each blood pump device, the flow rate of the blood pump device can be accurately estimated as soon as the blood pump device is implanted in the patient's body. Become.

(5) In the blood pump flow rate estimation method according to any one of (1) to (3), the first step includes motor rotation speed, motor current consumption, and test in each of the plurality of blood pumps. The step of creating general flow rate estimation information including correction information by measuring the flow rate of the blood pump when the attribute data of the liquid is changed using a flow meter, and the number of rotations of the motor and the motor in the actual blood pump Current flow and test fluid attribute data, and the flow rate of the blood pump is measured using a flow meter, and the obtained measurement data is substituted into correction information to estimate the flow rate in the actual blood pump from the general flow rate estimation information. It is also preferable that the method includes a step of creating information.

By adopting such a method, the flow rate estimation information is created using the test solution as in the case of the blood pump flow rate estimation method described in (4) above. This first step can be completed before shipment.
In addition, since the first step, which is complicated and time-consuming, can be performed before the blood pump device is implanted in the patient's body, the burden on the patient does not increase.
Furthermore, if the flow rate estimation information is created for each blood pump device, the flow rate of the blood pump device can be accurately estimated as soon as the blood pump device is implanted in the patient's body. Become.

  In addition, in the blood pump flow rate estimation method described in (5) above, the creation of flow rate estimation information that is inherently cumbersome and cumbersome, the step of creating general flow rate estimation information including correction information, and the correction information for each actual machine. Substituting the measurement data obtained in step 1 and creating the flow rate estimation information in the actual blood pump from the general flow rate estimation information. The blood pump is actually used, and the latter step (which does not require measurement by changing the motor rotation speed, motor current consumption, and test liquid attribute data as in the former step) is relatively easy. Therefore, as a whole, the flow rate estimation is easier than the blood pump flow rate estimation method described in (4). It is possible to create the information.

  The general flow rate estimation information including the correction information is information necessary for creating the flow rate estimation information, but the general flow rate estimation information itself includes correction information that is an indefinite term. The flow rate cannot be estimated by substituting measurement data about the motor rotation speed N, the motor consumption current I, and the patient blood attribute data Z in the actual blood pump embedded in the patient's body.

(6) In the blood pump flow rate estimation method according to any one of (1) to (3), the first step includes motor rotation speed, motor current consumption, and test in each of the plurality of blood pumps. In the actual blood pump embedded in the patient's body, the step of creating general flow rate estimation information including correction information by measuring the flow rate of the blood pump when the liquid attribute data is changed using a flow meter Measure the motor rotation speed, motor current consumption, and patient blood attribute data, measure the blood pump flow rate using a blood flow meter, and substitute the obtained measurement data into the correction information to estimate the general flow rate. And the step of creating flow rate estimation information in the actual blood pump from the information.

  By adopting such a method, as in the case of the blood pump flow rate estimation method described in (5) above, the creation of flow estimation information that is inherently cumbersome and time-consuming, the general flow rate estimation information itself including correction information itself And the step of substituting the measurement data obtained for each actual machine into the correction information and creating the flow estimation information in the blood pump actual machine from the general flow estimation information, and these steps are inherently cumbersome and laborious Since the former step is performed in advance using a plurality of blood pumps, and the latter step, which is relatively laborious, is performed using the blood pump actual machine, the blood pump flow rate estimation method according to (5) above As in the case of, the flow rate estimation information can be easily created as a whole.

  In addition, according to the blood pump flow rate estimation method described in (6) above, the blood pump is calculated from the general flow rate estimation information by substituting measurement data obtained by using a blood pump embedded in the patient's body into correction information. Since the flow estimation information for the actual machine is to be created, the flow estimation information for the actual blood pump in the actual machine usage environment will be created, so the accuracy of the flow estimation results will be degraded due to differences in the blood pump usage environment. Can be effectively suppressed.

  In addition, according to the blood pump flow rate estimation method described in (6) above, the blood pump is calculated from the general flow rate estimation information by substituting measurement data obtained by using a blood pump embedded in the patient's body into correction information. Since the flow rate estimation information in the actual machine can be created and then the flow rate can be estimated for the actual blood pump based on this flow rate estimation information, the accuracy of the flow rate estimation result deteriorates due to changes in blood pump characteristics over time. Can be effectively suppressed.

  Note that the general flow rate estimation information including the correction information is information necessary for creating the flow rate estimation information as described in the above (5), but the general flow rate estimation information itself is correction information that is an indefinite term. Therefore, the flow rate can be obtained even if measurement data about the rotation speed N of the blood pump embedded in the patient's body, the motor current consumption I, and the patient blood attribute data Z are substituted into this general flow rate estimation information. It cannot be estimated.

(7) In the blood pump flow rate estimation method according to (6) above, as the blood flow meter, a blood flow meter based on a thermodilution method, a blood flow meter based on a dye dilution method, an electromagnetic blood flow meter, an ultrasonic blood flow A blood flow meter based on transesophageal echo, a blood flow meter based on transthoracic echo, or a blood flow meter based on the electrical impedance method can be preferably used.

  By using such a blood flow meter, it becomes possible to measure the flow rate in the actual blood pump device implanted in the patient, and to accurately estimate the flow rate of the blood pump.

(8) In the blood pump flow rate estimation method described in (6) or (7) above, when the blood pump flow rate is estimated in the second step, the blood pump flow rate can be measured by a blood flow meter. In this case, it is preferable that the flow rate estimation information in the actual blood pump is updated by measuring the flow rate of the blood pump using a blood flow meter when performing the second step.

  By adopting such a method, even if there is a change in blood pump characteristics over time, the latest flow rate estimation information can be updated as appropriate, and the accuracy of the flow estimation result deteriorates due to the change in blood pump characteristics over time. This can be more effectively suppressed.

(9) The blood pump flow rate estimation method according to any one of (5) to (8) above can be particularly preferably used when the motor is a DC motor.

  In a DC motor, the motor current consumption I is proportional to the shaft torque. Further, the flow rate Q of the blood pump has a linear relationship with this shaft torque. For this reason, the flow rate Q of the blood pump has a linear relationship with the consumption current I of the motor, and it becomes easy to complete the flow rate estimation information in the blood pump actual machine from the general flow rate estimation information including the correction information.

(10) In the blood pump flow rate estimation method according to any one of (1) to (9), the attribute data of the liquid, the test liquid, or the blood of the patient is the test of the liquid. Preferably it is the viscosity and density of the fluid or of the patient's blood.

  By adopting such a method, it is possible to estimate the flow rate of the blood pump with higher accuracy than when only the viscosity or density is used as the attribute data of the test solution or the blood of the patient.

(11) In the blood pump flow rate estimation method according to (10) above, in the second step, instead of measuring “patient blood viscosity and density”, “patient blood hematocrit value” is measured. It is preferable to estimate the flow rate of the blood pump using “converted viscosity and converted density” obtained by conversion from the hematocrit value.

  By adopting such a method, it becomes possible to estimate the flow rate of the blood pump by a simple method that merely measures the hematocrit value without measuring the viscosity or density of the blood of the patient.

(12) In the blood pump flow rate estimation method according to any one of (1) to (11) above, when the blood pump is a blood pump having a mechanical seal portion for sealing a shaft of a motor rotation shaft. It can be particularly preferably used.

  Thus, the blood pump having a mechanical seal portion for sealing the shaft of the motor rotation shaft (that is, for sealing between the pump portion and the drive portion) is slidable between the pump portion and the drive portion, and Since it is sealed well, the leakage of blood from the pump unit to the drive unit is suppressed as much as possible, and the generation of thrombus is suppressed as much as possible, and the stoppage of the blood pump and the change in the operating state of the blood pump It will be suppressed as much as possible.

On the other hand, a predetermined pressure is required for such a mechanical seal portion. Since there is a relatively large individual difference in the pressure intensity, there is a relatively large individual difference in the blood pump characteristics.
However, according to the blood pump flow rate estimation method of the present invention, since flow rate estimation information is created for each blood pump actual machine, even if there are relatively large individual differences in blood pump characteristics, The influence of such individual differences can be eliminated, and as a result, it is possible to effectively suppress the deterioration of the accuracy of the flow rate estimation result due to individual differences in blood pump characteristics.

Moreover, in such a mechanical seal part, since the pressurization actually applied to the sliding surface varies relatively greatly depending on the use environment of the blood pump such as the posture of the motor, the blood pump characteristics also vary relatively large.
However, according to the blood pump flow rate estimation method according to (6) of the present invention, the measurement data obtained from the blood pump embedded in the patient's body is substituted into the correction information, and the flow rate estimation information is obtained from the general flow rate estimation information. Since the flow rate estimation information in the actual blood pump is to be created, even if the blood pump characteristics fluctuate relatively greatly depending on the usage environment of the blood pump, the effect of such fluctuations in the blood pump characteristics is effectively prevented. As a result, it is possible to effectively prevent the accuracy of the flow rate estimation result from deteriorating due to fluctuations in blood pump characteristics depending on the use environment.

In addition, since such a mechanical seal portion has a sliding surface whose sliding characteristics change greatly with time, there is also a great change with time in blood pump characteristics.
However, according to the blood pump flow rate estimation method according to (6) of the present invention, the measurement data obtained from the blood pump embedded in the patient's body is substituted into the correction information, and the flow rate estimation information is obtained from the general flow rate estimation information. Since the flow rate estimation information in the actual blood pump is to be created, even if the blood pump characteristics change over time, it is possible to effectively suppress the influence of such blood pump characteristics over time. As a result, it is possible to effectively prevent the accuracy of the flow rate estimation result from deteriorating due to a change in blood pump characteristics over time.

(13) In the blood pump flow rate estimation method of the present invention, the blood pump flow rate Q in a blood pump that feeds blood using the rotational force of the motor as a drive source is determined by the rotational speed N of the motor, the current consumption I of the motor, A blood pump flow rate estimation method that estimates based on blood blood attribute data Z,
The number of revolutions N of the motor and current consumption I of the motor and the attribute data Z of the blood of the patient in the blood pump actual machine implanted in the patient's body are measured, and the flow rate estimation information and these values in the blood pump actual machine prepared in advance The flow rate Q of the blood pump is estimated based on N, I, and Z.

  For this reason, according to the blood pump flow rate estimation method of the present invention, the rotational speed N of the motor and the current consumption I of the motor and the blood blood attribute data Z in the blood pump embedded in the patient's body are measured in advance. Since the blood flow rate Q of the blood pump is estimated on the basis of the flow rate estimation information and the values N, I, and Z in the actual blood pump that has been created, the flow rate estimation result is based on individual differences in blood pump characteristics. The object of the present invention is achieved.

(14) A blood pump flow rate estimation apparatus according to the present invention has a function of estimating a blood pump flow rate by the blood pump flow rate estimation method according to any one of (1) to (13) above. A flow estimation information storage unit that stores flow rate estimation information in the blood pump actual machine, the motor rotation speed N, the motor current consumption I, and patient blood attribute data Z, And a flow rate estimating unit for estimating a flow rate Q of the blood pump based on the flow rate estimation information stored in the information storage unit.

  Therefore, according to the blood pump flow rate estimation apparatus of the present invention, the blood pump actual device stored in the flow rate estimation information storage unit from the motor rotation speed N, the motor current consumption I, and the patient blood attribute data Z Since the blood flow rate Q of the blood pump can be estimated based on the flow rate estimation information in FIG. 5, the accuracy of the flow rate estimation result does not deteriorate due to individual differences in blood pump characteristics, and the object of the present invention is achieved.

(15) A blood pump system according to the present invention is a blood pump system comprising a blood pump for feeding blood using the rotational force of a motor as a drive source, and an external controller for controlling the operation of the blood pump, The blood flow rate estimation device according to (14) is further provided.

  For this reason, according to the blood pump system of the present invention, since it has the excellent blood pump flow rate estimation device as described above, the accuracy of the flow rate estimation result does not deteriorate due to individual differences in blood pump characteristics, The object of the present invention is achieved.

(16) A storage medium according to the present invention is a storage medium for use in the blood pump flow rate estimation apparatus according to (14), and stores general flow rate estimation information including the correction information or the flow rate estimation information. It is characterized by.

  For this reason, according to the storage medium of the present invention, by using this storage medium, it becomes possible to realize an excellent blood pump flow rate estimation device as described above. The accuracy of the flow rate estimation result is not deteriorated, and the object of the present invention is achieved.

Sectional drawing which shows a blood pump. The figure shown in order to demonstrate the blood pump system which concerns on Embodiment 1. FIG. The figure shown in order to demonstrate the flow volume estimation method of the blood pump which concerns on Embodiment 1. FIG. The figure which shows the relationship between a flow coefficient and conversion current for every rotation speed of a motor. The figure which shows the difference of the actual machine and arbitrary blood pumps in the consumption current of a motor when changing the flow volume of a blood pump for every rotation speed of a motor. The figure which shows the difference (ratio) between the real machine and arbitrary blood pumps in the consumption current of a motor when changing the rotation speed of a motor. The figure which shows the difference of the estimation flow volume of a blood pump actual machine, and a measurement flow volume. The figure which shows the relationship between a hematocrit value and the viscosity of the blood. The figure which shows the relationship between a hematocrit value and the density of blood. The figure shown in order to demonstrate the blood pump system which concerns on Embodiment 2. FIG. The figure shown in order to demonstrate the flow volume estimation method of the blood pump which concerns on Embodiment 2. FIG. The figure shown in order to demonstrate the blood pump system which concerns on Embodiment 3. FIG. The figure shown in order to demonstrate the flow volume estimation method of the blood pump which concerns on Embodiment 3. FIG. The figure shown in order to demonstrate the conventional blood pump system. The figure shown in order to demonstrate the flow volume estimation method of the conventional blood pump.

Hereinafter, a blood pump flow rate estimation method, a blood pump flow rate estimation apparatus, a blood pump system, and a storage medium to which the present invention is applied will be described based on embodiments shown in the drawings.
First, before describing each embodiment of the present invention, a blood pump used in each embodiment of the present invention will be described with reference to FIG.

  FIG. 1 is a cross-sectional view showing a blood pump used in each embodiment of the present invention. As shown in FIG. 1, the blood pump 10 includes a drive unit 11 having a cylindrical motor and a pump unit 12 connected to the drive unit 11. The pump unit 12 includes an impeller 13 that is driven via a rotating shaft of a motor, and a pump casing 14 that is connected to the drive unit 11 so as to cover the impeller 13. After the blood in the left ventricle of the heart in the human body flows into the pump casing 14 via the artificial blood vessel and the inflow port 15 and is given flow energy by the impeller 13, the outflow port 16 provided on the side surface of the pump casing 14 and It is configured to flow out to the aorta via an artificial blood vessel.

In the blood pump 10, a mechanical seal portion 17 is provided between the drive portion 11 and the pump portion 12. For this reason, according to this blood pump 10, the pump part 12 and the drive part 11 are slidably and satisfactorily sealed, and blood leaks from the pump part 12 to the drive part 11 as much as possible. It is suppressed. As a result, thrombus generation is suppressed as much as possible, and stoppage of the blood pump and changes in the operating state of the blood pump are suppressed as much as possible.
On the other hand, in this blood pump 10, since the mechanical seal portion 17 is provided, there are large individual differences, usage environment dependence, and changes with time in the blood pump characteristics. For this reason, it is not easy to accurately estimate the flow rate of such a blood pump 10. Therefore, in order to appropriately treat a severe heart disease using such a blood pump 10, the flow rate of the blood pump 10 There is a particular need for a blood pump flow rate estimation method that can perform estimation accurately.

  In each embodiment, the blood pump 10 is a centrifugal blood pump that can take a larger blood flow than the axial flow motor. In each embodiment, a DC motor is used as a motor for driving the impeller 13 of the blood pump 10.

[Embodiment 1]
The first embodiment is an embodiment of a blood pump flow rate estimating method, a blood pump flow rate estimating apparatus and a blood pump system to which the blood pump flow rate estimating method is applied.
FIG. 2 is a diagram for explaining the blood pump system according to the first embodiment of the present invention. As shown in FIG. 2, the blood pump system 100A includes a blood pump (blood pump actual machine) 10 that sends blood using the rotational force of a motor as a drive source, and an external controller 20 that controls the operation of the blood pump actual machine 10. The blood pump flow rate estimation device 30A for estimating the flow rate of the actual blood pump 10 is provided.
The external controller 20 includes a drive controller (not shown) for driving the blood pump actual machine 10 and a circulating fluid controller (not shown) for lubricating and cooling the mechanical seal part in the blood pump actual machine 10. In addition, a rotation speed measurement unit 21 that measures the rotation speed N of the motor and a consumption current measurement unit 22 that measures the consumption current I of the motor are further included.
In the blood pump system 100A according to the first embodiment, the external controller 20 and the blood pump flow rate estimation device 30A are configured as separate units. However, the present invention is not limited to this, and the external controller is a blood pump. It may have a flow rate estimation function (indicated by 20A in FIG. 2).

The blood pump flow rate estimation device 30A includes an attribute data input unit 32 for inputting attribute data of the test liquid or the blood of the patient, the motor rotation speed, the motor current consumption, the test liquid attribute data, and the blood pump A general flow rate estimation formula storage unit 33 that stores a general flow rate estimation formula including a correction term, created based on the flow rate, a motor rotation speed N ₀ , a motor current consumption I ₀ , and patient blood attribute data Z _0. And the flow rate estimation formula created by the flow rate estimation formula creation unit 34 by substituting the measurement data for the flow rate Q ₀ of the blood pump into the correction term and creating the flow rate estimation formula in the blood pump actual machine 10. Based on the flow rate estimation formula stored in the flow rate estimation formula storage unit 35 from the flow rate estimation formula storage unit 35, the motor rotation speed N, the motor current consumption I, and the patient blood attribute data Z , And a flow rate estimation unit 36 for estimating the flow rate Q of the blood pump, a control unit 31 for controlling these. Moreover, it has a connection part (not shown) with the blood flow meter 50 which measures the flow volume of the blood pump actual machine 10.

The blood flow rate estimation device 30A according to the first embodiment includes the flow rate estimation formula creation unit 34 and the flow rate estimation formula storage unit 35. However, the present invention is not limited to this, and the flow rate estimation formula creation is performed. A blood pump flow rate estimation device that does not include the unit 34 and the flow rate estimation formula storage unit 35 is also included. In this case, the flow rate estimation unit 36, the general flow rate estimation formula including the correction term stored in the general flow rate estimation formula storage unit 33, the measured motor rotation speed N ₀ , the motor current consumption I ₀ , the patient A blood flow estimation formula in the blood pump actual machine 10 is created from measurement data consisting of blood blood attribute data Z ₀ and blood pump flow rate Q ₀ every time the flow estimation is performed, and based on the flow estimation formula in the blood pump actual machine 10 Thus, the flow rate Q of the blood pump in the blood pump actual machine 10 is estimated. In this case, it is preferable to include a measurement data storage unit that stores the above-described measurement data.

  FIG. 3 is a diagram for explaining the blood pump flow rate estimation method according to the first embodiment. The blood pump flow rate estimation method according to the first embodiment includes a first step and a second step, as shown in FIG.

(First step)
The first step includes a step of creating a general flow rate estimation formula including a correction term and a step of creating a flow rate estimation formula in the blood pump actual machine 10.
Among these, the step of creating the general flow rate estimation formula including the correction term is to prepare a plurality of blood pumps having the same standard and model number as the blood pump actual machine 10, and the motor rotation speed and motor in each of the plurality of blood pumps The individual differences among multiple blood pumps are reflected by measuring the flow rate of the blood pump when the consumption current and the attribute data of the test solution are changed using a flow meter (not shown in FIG. 2). This is a step of creating a general flow rate estimation formula including the corrected term.
As the test solution, for example, water and a mixed solution of water and glycerin adjusted to a plurality of viscosities are used. As attribute data of the test solution, viscosity μ and density ρ are used.

Further, the step of creating the flow rate estimation formula in the blood pump actual machine 10 includes the motor rotation speed N _{0, the} motor current consumption I _{0 and} the blood data attribute data Z ₀ of the patient in the blood pump actual machine 10 embedded in the patient's body. (At least once) The flow rate Q ₀ of the blood pump at that time is measured using the blood flow meter 50, and the obtained measurement data is substituted into the correction term to calculate the actual blood pump 10 from the general flow rate estimation information. This is a step of creating a flow rate estimation formula in FIG. Viscosity μ and density ρ are used as attribute data of patient blood.

Of these steps, the step of creating the general flow rate estimation formula is generally performed collectively using a plurality of blood pumps before the blood pump actual machine 10 is shipped.
Of these steps, the step of creating the flow rate estimation formula in the blood pump actual machine 10 is performed using the blood pump actual machine 10 after the blood pump actual machine 10 is embedded in the body of the patient.

(Step of creating a general flow rate estimation formula including a correction term in the first step)
In this step, a plurality of blood pumps are prepared, and the flow rate of the blood pump when the motor rotation speed, motor consumption current, and test liquid attribute data are changed in each of the plurality of blood pumps is measured by a flow meter ( This is a step of creating a general flow rate estimation formula including a correction term by measuring using an industrial flow meter or the like.

FIG. 4 shows a flow coefficient φ (= blood pump flow rate Q / (flow path area A / impeller peripheral speed u)) and motor consumption in the blood pump system according to the first embodiment. The relationship between the converted current ι (= motor current consumption I / (test solution density ρ · angular velocity ω ² )), which standardizes the current I, is the viscosity μ (0.7 cP, 2.5 cP, 3.5 cP of the test solution). , 4.5 cP) and motor speed N (1000 rpm, 1400 rpm, 1800 rpm, 2200 rpm).
In the blood pump system 100A, as shown in FIG. 4, the flow coefficient φ has a substantially linear relationship with the converted current ι, and therefore, from these data, the rotational speed N of the motor is approximated to a linear expression by the least square method. The relational expression (1) can be created. Each coefficient at this time can be expressed as a function of the viscosity μ of the test solution.

  ι = (C ・ μ + D) φ + (E ・ μ + F) (1)

At this time, the coefficients C, D, E, and F can be expressed as a function of the rotational speed N of the motor. For example, the following functions can be used.
C (N) = − 1.12 × 10 ⁻¹¹ N ³ + 4.83 × 10 ⁻⁸ N ² −6.32 × 10 ⁻⁵ N + 2.76 × 10 ⁻²
D (N) = 6.57 × 10 ⁻⁵ N-9.39 × 10 ⁻³
E (N) = 8.85 × 10 ⁻⁸ N + 6.34 × 10 ⁻⁴
F (N) = 2.00 × 10 ⁻⁹ N ² −8.85 × 10 ⁻⁶ N + 1.38 × 10 ⁻²

  Thereafter, by developing this relational expression (1), the following basic estimation expression (2) can be obtained.

FIG. 5 is a diagram showing the difference between the actual machine and any blood pump in the current consumption of the motor when the flow rate of the blood pump is changed, for each number of rotations of the motor. As shown in FIG. 5, it can be seen that the difference between the actual blood pump 10 and the arbitrary blood pump in the current consumption of the motor is almost constant regardless of the flow rate of the actual blood pump 10 at any rotation speed.
FIG. 6 is a diagram showing a difference (ratio) between the actual machine and an arbitrary blood pump in the current consumption of the motor when the rotation speed of the motor is changed. As shown in FIG. 6, it can be seen that the difference (ratio) between the actual blood pump 10 and the arbitrary blood pump in the current consumption of the motor is substantially constant regardless of the number of rotations of the motor.

  From these, it can be seen that the flow rate Q of the blood pump is a value that is offset by a predetermined value from the flow rate in any blood pump, regardless of the rotational speed of the motor and the current consumption of the motor. Therefore, if this offset amount is measured using the blood pump actual device 10 and a correction corresponding to this offset amount is added to the estimation result by the basic estimation formula (2), a more accurate flow rate estimation result in the blood pump actual device 10 can be obtained. Will be obtained. For this reason, the following general flow rate estimation formula (3) in which a correction term is incorporated in the basic estimation formula (2) is created so that the correction process in the step of creating the flow rate estimation formula in the subsequent blood pump actual machine becomes easy. Keep it.

ここで、ｉ_＊、μ_＊、φ_＊は、後のステップで測定される測定データｉ_０、μ_０、φ_０が代入される変数項である。

Here, i _* , μ _* , and φ _* are variable terms into which measurement data i ₀ , μ ₀ , and φ ₀ measured in a later step are substituted.

  In the blood pump system 100A, the general flow rate estimation formula (3) including the correction term created in this way is stored in the general flow rate estimation formula storage unit 33.

(Step of creating a flow rate estimation formula in the actual blood pump in the first step)
In this step, the rotation speed of the motor and the motor current consumption in the actual blood pump 10 embedded in the patient's body and the attribute data of the blood of the patient are measured, and the flow rate of the blood pump is measured using the blood flow meter 50. In this step, the obtained data is substituted into the correction term to create a flow rate estimation formula in the actual blood pump from the general flow rate estimation formula (3).

As described above, the flow rate Q of the blood pump is a value that is offset by a predetermined value from the flow rate of an arbitrary blood pump, regardless of the rotational speed of the motor and the current consumption of the motor. Therefore, for the blood pump actual machine 10 implanted in the patient's body, the motor rotation speed N _{0, the} motor consumption current I ₀ , and the patient blood attribute data Z ₀ are measured (at least once), and at that time The blood flow rate Q _{0 of the} blood pump is measured using the blood flow meter 50, and the obtained measurement data is substituted into the correction term of the general flow rate estimation formula (3) to calculate the flow rate estimation formula (4) in the blood pump actual machine 10. Create

  The flow rate estimation formula (4) in the blood pump actual machine 10 is created by the flow rate formula creation unit 34. Then, the obtained flow rate estimation formula (4) is stored in the flow rate estimation formula storage unit 35.

(Second step)
In this second step, the motor rotation speed N, the motor current consumption I and the patient blood attribute data Z in the blood pump actual machine 10 implanted in the body of the patient are measured and stored in the flow rate estimation formula storage unit 35. This is a step of estimating the flow rate Q of the blood pump based on the flow rate estimation formula (4) and these values N, I, and Z. Viscosity μ and density ρ are used as attribute data of patient blood.
For the motor rotation speed N and the motor current consumption I, measurement data is obtained by performing automatic measurement every time the flow rate is estimated, and the patient blood attribute data Z (μ, φ) is attributed. Measurement data is acquired by inputting using the data input unit 32.

  FIG. 7 shows the difference between the estimated flow rate of the actual blood pump obtained by estimation using the flow rate estimation formula (4) and the measured flow rate actually measured using the flow meter under appropriate conditions. FIG. As shown in FIG. 7, these differences are smaller than the target value (± 1 liter / minute) considered to be clinically acceptable when the flow rate of the blood pump is 10 liter / minute or less. It was confirmed that the blood pump flow rate estimation method according to Embodiment 1 can accurately estimate the blood pump flow rate.

  The flow estimation method for the blood pump according to the first embodiment has been described above. However, according to the flow estimation method for the blood pump according to the first embodiment, the blood pump actual machine 10 that performs the flow estimation in the first step. Since the flow rate estimation formula (4) is created for the blood pump 10 in the second step based on the flow rate estimation formula (4), the flow rate is estimated based on individual differences in blood pump characteristics. It can suppress effectively that the precision of an estimation result deteriorates.

  Further, according to the blood pump flow rate estimation method according to the first embodiment, since the flow rate estimation formula (4) is created using the blood pump actual machine 10 embedded in the body of the patient, Since the flow rate estimation formula (4) for the blood pump actual machine 10 is created, it is possible to effectively suppress the deterioration of the accuracy of the flow rate estimation result due to the difference in the usage environment of the blood pump. .

  In addition, according to the blood pump flow rate estimation method according to the first embodiment, the flow rate estimation formula (4) is created using the blood pump actual device 10 embedded in the patient's body, and then the flow rate estimation formula (4) is set. Based on this, it becomes possible to perform the flow rate estimation for the blood pump actual machine 10, so that it is possible to effectively suppress the deterioration of the accuracy of the flow rate estimation result due to the temporal change of the blood pump characteristics.

  In addition, according to the flow rate estimation method of the blood pump according to the first embodiment, the creation of the flow rate estimation formula (4) that is inherently cumbersome and laborious, the step of creating the general flow rate estimation formula (3) including the correction term, Substituting measurement data for each actual machine into the correction term and creating a flow rate estimation formula 4) in the actual blood pump machine, the former step, which is cumbersome and time-consuming among these steps, is performed using a plurality of blood pumps in advance. The latter step, which is relatively laborious, is performed using the blood pump actual machine, so that the flow rate estimation formula (4) can be easily created as a whole.

  In the blood pump flow rate estimation method according to the first embodiment, when the blood pump flow rate is estimated in the second step and the blood flow rate of the blood pump 10 can be measured by the blood flow meter 50, the second step. When performing the step, the flow rate of the blood pump 10 is measured using the blood flow meter 50 so that the flow rate estimation formula (4) is always updated to the latest flow rate estimation formula (4) as appropriate. For this reason, even if there is a change over time in the blood pump characteristics, it becomes possible to estimate the flow rate of the blood pump using the latest flow estimation formula (4). It becomes possible to more effectively suppress the deterioration of accuracy.

  In the blood pump flow rate estimation method according to the first embodiment, a blood flow meter based on the thermodilution method is used as the blood flow meter 50. In this case, if the rotational speed of the motor in the blood pump actual device 10 is adjusted so that all blood in the systemic circulation system passes through the blood pump actual device 10 with reference to a blood monitor, an ultrasonic diagnostic apparatus, etc., the blood flow meter 50 Since the blood flow rate obtained by the above is substantially equal to the blood flow rate in the actual blood pump 10, the blood pump flow rate can be accurately estimated. When measuring the flow rate with the blood flow meter 50, it is necessary to embed a catheter in the patient's body, but such a catheter is usually implanted for a certain period after the operation of implanting the blood pump. Therefore, it does not give an additional burden to the patient.

  In the blood pump flow rate estimation method according to the first embodiment, viscosity and density are used as attribute data of the test liquid and the blood of the patient. For this reason, compared with the case where only either a viscosity or a density is employ | adopted, the flow volume estimation of a blood pump with high precision is attained.

  In the blood pump flow rate estimation method according to Embodiment 1, instead of measuring the blood viscosity and density of the patient in the second step, the hematocrit value is measured, and the converted viscosity and conversion obtained by conversion from this hematocrit value The flow rate of the blood pump may be estimated using the density. In the case of such a method, the blood pump flow rate can be estimated by a simple method of simply measuring the hematocrit value without measuring the viscosity or density of the patient's blood.

  FIG. 8 is a diagram showing a relationship between blood hematocrit value and blood viscosity, and FIG. 9 is a diagram showing a relationship between blood hematocrit value and blood density. As shown in FIGS. 8 and 9, there is a strong correlation between the hematocrit value of blood and the viscosity and density of blood. That is, in the patient's blood as well, since there is a strong correlation between the hematocrit value Ht of the patient's blood and the viscosity μ and density ρ of the patient's blood, the viscosity μ and density ρ of the patient's blood Can be obtained by measuring the hematocrit value Ht of the patient's blood and converting the viscosity μ and density ρ of the patient's blood from the hematocrit value Ht of the patient's blood.

  As described above, the blood pump flow rate estimation method according to the first embodiment effectively suppresses deterioration of the accuracy of the flow rate estimation result due to individual differences of blood pumps, use environment dependence, and changes over time. Because it is an excellent blood pump flow rate estimation method that can be performed, by using such an excellent blood pump flow rate estimation method, treatment using an implantable blood pump can be performed more appropriately. Become.

  Further, the blood pump flow rate estimating apparatus 30A according to the first embodiment can effectively suppress the deterioration of the accuracy of the flow rate estimation result due to the individual difference of the blood pump, the use environment dependency, and the change with time, as described above. Since an excellent blood pump flow rate estimation method can be used to estimate the blood pump flow rate, the use of such an excellent blood pump flow rate estimation device 30A enables treatment using an implantable blood pump. Can be performed more appropriately.

  Further, as described above, the blood pump system 100A according to the first embodiment can effectively suppress deterioration of the accuracy of the flow rate estimation result due to individual differences of blood pumps, use environment dependency, and changes with time. Since the blood pump system includes the pump flow rate estimation device 30A, the use of such an excellent blood pump system 100A enables more appropriate treatment using an implantable blood pump. Become.

  Furthermore, the general flow estimation formula to be stored in the general flow estimation formula storage unit 33 or the flow estimation formula in the blood pump actual machine 10 to be stored in the flow estimation formula storage unit 35 in the blood pump flow estimation device 30A according to the first embodiment. Is stored in a predetermined storage medium (for example, a CD-ROM), the flow rate estimation formula stored in the storage medium is read into the computer system, thereby making the computer system a blood flow rate estimation device 30A. Will be able to. For this reason, by using such a storage medium, it is possible to more appropriately perform treatment using an implantable blood pump.

[Embodiment 2]
The second embodiment is an embodiment of a blood pump flow rate estimation method, a blood pump flow rate estimation apparatus and a blood pump system to which the blood pump flow rate estimation method is applied.
FIG. 10 is a view for explaining the blood pump system according to the second embodiment of the present invention. Blood pump system 100B (and blood pump flow rate estimation device 30B) according to Embodiment 2 does not include a connection with a blood flow meter as shown in FIG. 10, except that blood according to Embodiment 1 is provided. It has the same configuration as the pump system 100A (and the blood pump flow rate estimation device 30A).

  FIG. 11 is a diagram for explaining a blood pump flow rate estimation method according to the second embodiment. The blood pump flow rate estimation method according to the second embodiment includes a first step and a second step, as shown in FIG.

(First step)
The first step includes a step of creating a general flow rate estimation formula including a correction term and a step of creating a flow rate estimation formula in the blood pump actual machine 10.
Among these, the step of creating the general flow rate estimation formula including the correction term is to prepare a plurality of blood pumps having the same standard and model number as the blood pump actual machine 10, and the motor rotation speed and motor in each of the plurality of blood pumps A general flow rate estimation formula including a correction term by measuring the flow rate of the blood pump when changing the current consumption and the attribute data of the test solution using a flow meter (industrial flow meter, etc.) It is.
As the test solution, for example, water and a mixed solution of water and glycerin adjusted to a plurality of viscosities are used. As attribute data of the test solution, viscosity μ and density ρ are used. This is the same as the flow rate estimation method for the blood pump according to the first embodiment.

  The step of creating the flow rate estimation formula in the blood pump actual machine 10 measures the rotation speed of the motor, the motor consumption current, and the attribute data of the test liquid in the blood pump actual machine 10, and uses the flow meter to determine the flow rate of the blood pump. In this step, the flow rate estimation formula in the blood pump actual machine 10 is created from the general flow rate estimation information by substituting the obtained data into the correction term. As the test solution, for example, water or a mixed solution of water and glycerin is used. In particular, it is preferable to use a solution adjusted to have a viscosity equivalent to that of blood. As attribute data of the test solution, viscosity μ and density ρ are used.

Among these steps, the step of creating the general flow rate estimation formula including the correction term is performed in a lump using a plurality of blood pumps before the blood pump actual machine 10 is shipped, as in the first embodiment.
Of these steps, the step of creating the flow rate estimation formula in the blood pump actual machine 10 is performed using the blood pump actual machine 10 before shipment of the blood pump actual machine 10, unlike the case of the first embodiment.

(Second step)
In this second step, the rotational speed N of the motor in the blood pump actual machine 10 implanted in the patient's body, the current consumption I of the motor, and the attribute data Z of the patient's blood are measured, and the flow rate in the blood pump actual machine 10 created earlier is measured. This is a step of estimating the flow rate Q of the blood pump in the actual blood pump 10 based on the estimation formula and these values N, I, and Z. This second step is the same as in the first embodiment. Viscosity μ and density ρ are used as attribute data of patient blood.
As in the case of the first embodiment, this second step is performed after the blood pump actual machine 10 is implanted in the patient's body.

  Therefore, according to the blood pump flow rate estimation method according to the second embodiment, as in the case of the first embodiment, a flow rate estimation formula is created for the blood pump actual machine 10 in which the flow rate is estimated in the first step. In the second step, since the flow rate estimation for the blood pump actual machine 10 is performed based on the flow rate estimation formula, it is effective that the accuracy of the flow rate estimation result deteriorates due to individual differences in blood pump characteristics. Can be suppressed.

Further, according to the blood pump flow rate estimation method according to the second embodiment, unlike the blood pump flow rate estimation method according to the first embodiment, the flow rate estimation formula is created using the test solution. Thus, the first step which is complicated and laborious can be completed before shipment.
In addition, since the first step, which is complicated and time-consuming, can be performed before the blood pump device is implanted in the patient's body, the burden on the patient does not increase.
Furthermore, if the flow rate estimation formula is created for each blood pump device, the flow rate of the blood pump device can be accurately estimated as soon as the blood pump device is implanted in the patient's body. Become.

  In the blood pump flow rate estimation method according to the second embodiment, the creation of the inherently cumbersome and troublesome flow rate estimation formula in the first step, the step of creating a general flow rate estimation formula including a correction term, and the flow rate in the blood pump actual machine Since the estimation step is divided into the step of creating an estimation formula and the latter step is performed before shipment, the flow rate estimation formula is created more easily as a whole than the blood pump flow rate estimation method according to the first embodiment. Be able to.

  As described above, the flow rate estimation method for the blood pump according to the second embodiment is an excellent blood pump that can effectively suppress the deterioration of the accuracy of the flow rate estimation result due to individual differences in the blood pump as described above. Since this is a flow rate estimation method, treatment using an implantable blood pump can be performed more appropriately by using such a superior blood pump flow rate estimation method.

  In addition, the blood pump flow rate estimation device 30B according to the second embodiment can effectively suppress the deterioration of the accuracy of the flow rate estimation result due to the individual difference of the blood pump as described above. Can be used to estimate the flow rate of the blood pump, so that the treatment using the implantable blood pump can be performed more appropriately by using such an excellent blood pump flow rate estimation device 30B. become able to.

  In addition, the blood pump system 100B according to the second embodiment includes the excellent blood pump flow rate estimation device 30B that can effectively suppress the deterioration of the accuracy of the flow rate estimation result due to the individual difference of the blood pumps as described above. Therefore, even when such an excellent blood pump system 100B is used, treatment using the implantable blood pump can be performed more appropriately.

  Furthermore, the general flow rate estimation formula to be stored in the general flow rate estimation formula storage unit 33 or the flow rate estimation formula in the blood pump actual machine to be stored in the flow rate estimation formula storage unit 35 in the flow rate estimation device 30B of the blood pump according to the second embodiment. If stored in a predetermined storage medium (for example, CD-ROM), the computer system can be used as the blood flow rate estimation device 30B by causing the computer system to read the formula stored in the storage medium. It becomes like this. For this reason, by using such a storage medium, it is possible to more appropriately perform treatment using an implantable blood pump.

  In the blood pump system 100B (and the blood pump flow estimation device 30B) according to the second embodiment, the general flow estimation formula storage unit 33 and the flow estimation formula creation unit 34 may be omitted. This is because these parts are functions necessary for performing the first step before shipment, and thus are not essential in the blood pump system 100B (and blood pump flow rate estimation device 30B) after shipment.

[Embodiment 3]
The third embodiment is an embodiment of a blood pump flow rate estimation method and a blood pump flow rate estimation apparatus and a blood pump system to which the blood pump flow rate estimation method is applied.
FIG. 12 is a view for explaining the blood pump system according to the third embodiment of the present invention. The blood pump system 100C according to the third embodiment (and the blood pump flow rate estimation device 30C) is not provided with a general flow rate estimation formula storage unit 33 and a flow rate estimation formula creation unit 34 as shown in FIG. The blood pump system 100B according to the second embodiment (and the blood pump flow rate estimation device 30B) has the same configuration.

  FIG. 13 is a diagram for explaining the blood pump flow rate estimation method according to the third embodiment. The blood pump flow rate estimation method according to the third embodiment includes a first step and a second step, as shown in FIG.

(First step)
The first step uses a flow meter (such as an industrial flow meter) to measure the blood pump flow rate when the motor rotation speed, motor current consumption, and test liquid attribute data in the blood pump actual machine 10 are changed. This is a step of creating a flow rate estimation formula as flow rate estimation information describing the relationship between the motor rotation speed, the motor current consumption, the blood pump flow rate, and the liquid attribute data in the actual blood pump 10. As the test solution, for example, water and a mixed solution of water and glycerin adjusted to a plurality of viscosities are used. As attribute data of the test solution, viscosity μ and density ρ are used.
This first step is usually performed for each blood pump before the blood pump 10 is shipped.

(Second step)
In the second step, the rotational speed N of the motor in the blood pump actual machine 10 implanted in the patient's body, the current consumption I of the motor, and the attribute data Z of the patient's blood are measured, and the flow rate estimation formula and these values N, I, This is a step of estimating the flow rate Q of the blood pump in the actual blood pump 10 based on Z. Viscosity μ and density ρ are used as attribute data of patient blood. This is the same as in the first and second embodiments.
This second step is performed after the blood pump actual machine 10 is implanted in the patient's body.

  Therefore, according to the blood pump flow rate estimation method according to the third embodiment, in the first step, the flow rate estimation formula is determined for the blood pump actual machine 10 to be estimated, and in the second step, this flow rate is determined. Since the flow rate of the blood pump actual machine 10 is estimated based on the estimation formula, it is possible to effectively suppress the deterioration of the accuracy of the flow rate estimation result due to individual differences in blood pump characteristics.

The step of creating the flow rate estimation formula in the first step is a complicated and time-consuming step. This is because in order to determine the flow rate estimation formula, it is necessary to measure the flow rate by changing the motor rotation speed, the motor current consumption, and the liquid attribute data.
However, according to the blood flow rate estimation method according to the third embodiment, since the flow rate estimation formula is created using the test solution, the first step, which is complicated and laborious, is completed before shipping. Can be left.
In addition, since the first step, which is complicated and time-consuming, can be performed before the blood pump device is implanted in the patient's body, the burden on the patient does not increase.
Furthermore, if the flow rate estimation formula is created for each blood pump device, the flow rate of the blood pump device can be accurately estimated as soon as the blood pump device is implanted in the patient's body. Become.

  As described above, the blood flow rate estimation method according to the third embodiment is an excellent blood pump that can effectively suppress the deterioration of the accuracy of the flow rate estimation result due to the individual difference of the blood pump as described above. Since this is a flow rate estimation method, treatment using an implantable blood pump can be performed more appropriately by using such a superior blood pump flow rate estimation method.

  In addition, the blood pump flow rate estimation apparatus 30C according to the third embodiment can effectively suppress the deterioration of the accuracy of the flow rate estimation result due to the individual differences of the blood pumps as described above, and can be effectively suppressed. Can be used to estimate the flow rate of the blood pump. Therefore, the treatment using the implantable blood pump can be performed more appropriately by using such an excellent blood pump flow rate estimation device 30C. become able to.

  In addition, the blood pump system 100C according to the third embodiment includes the excellent blood pump flow estimation device 30C that can effectively suppress the deterioration of the accuracy of the flow estimation result due to the individual difference of the blood pump as described above. Therefore, even when such an excellent blood pump system 100C is used, treatment using an implantable blood pump can be performed more appropriately.

  Furthermore, if a flow rate estimation formula to be stored in the flow rate estimation formula storage unit 35 of the blood pump flow rate estimation apparatus 30C according to the third embodiment is stored in a predetermined storage medium (for example, a CD-ROM), this storage medium is stored. The computer system can be used as the blood flow rate estimation device 30C by reading the flow rate estimation formula stored in the computer system into the computer system. For this reason, by using such a storage medium, it is possible to more appropriately perform treatment using an implantable blood pump.

  The blood pump flow rate estimation method and blood pump system according to the present invention have been described above based on the above-described embodiments, but the present invention is not limited to this, and various modifications as exemplified below are possible. It is.

(A) In each of the embodiments described above, the flow rate estimation formula (and the general flow rate estimation formula) is used as the flow rate estimation information, but the present invention is not limited to this, and the flow rate estimation table (and A general flow rate estimation table) can be used, and similar effects can be obtained.

(B) In each of the above-described embodiments, a blood pump provided with a mechanical seal portion is used as a blood pump. However, the present invention is not limited to this, and individual differences in blood pumps, use environment dependence, aging Similar effects can be obtained when other blood pumps with changes are used.

(C) In Embodiment 3 described above, a blood pump provided with a DC motor is used as the blood pump. However, Embodiment 3 also applies when a blood pump using another motor is used instead of the DC motor. The same effect as in the case of can be obtained.

(D) In each of the above-described embodiments, the centrifugal pump is used as the blood pump. However, the present invention is not limited to this, and when other blood pumps (for example, axial flow pumps) are used, Similar effects can be obtained.

(E) In Embodiment 1 described above, the blood flow meter based on the thermodilution method was used as the blood flow meter, but instead of this blood flow meter, another blood flow meter (for example, a blood flow meter based on the dye dilution method, When using an electromagnetic blood flow meter, an ultrasonic blood flow meter, a blood flow meter based on transesophageal echo, a blood flow meter based on transthoracic echo, and a blood flow meter based on an electrical impedance method, the same as in the case of the first embodiment The effect of can be obtained.

(F) As an industrial flowmeter used in each of the above-described embodiments, an ultrasonic flowmeter, an electromagnetic flowmeter, and other various industrial flowmeters can be used.

DESCRIPTION OF SYMBOLS 10 ... Blood pump (blood pump actual machine), 11 ... Drive part, 12 ... Pump part, 13 ... Impeller, 14 ... Pump casing, 15 ... Inlet, 16 ... Outlet, 17 ... Mechanical seal part, 20 ... External controller, DESCRIPTION OF SYMBOLS 21 ... Number-of-rotations measurement part, 22 ... Current consumption measurement part, 30A, 30B, 30C ... Blood pump flow rate estimation device, 31 ... Control part, 32 ... Attribute data input part, 33 ... General flow rate estimation formula storage part, 34 ... Flow rate estimation formula creation unit, 35 ... flow rate estimation formula storage unit, 36 ... flow rate estimation unit, 50 ... blood flow meter, 100A, 100B, 100C ... blood pump system, 901 ... blood pump system, 905 ... blood pump, 921 ... impeller , 934 ... Motor, 955 ... Sensor circuit, 957 ... Blood parameter input unit, 958 ... Discharge flow rate calculation unit, 960 ... Viscosity rotation speed motor current discharge flow rate function Data storage unit

Claims (11)

  A blood pump flow rate estimation method for estimating the flow rate Q of the blood pump in the actual blood pump 10 embedded in the patient's body based on the motor rotation speed N, the motor current consumption I, and the patient blood attribute data Z. There,
  General flow rate including correction information by measuring the flow rate of the blood pump when the motor rotation speed, motor current consumption, and test liquid attribute data are changed in each of the plurality of blood pumps using a flow meter. A step of creating estimated information, and measuring the number of rotations of the motor and the motor current consumption in the blood pump actual machine 10 and the attribute data of the test solution, and measuring the flow rate of the blood pump using a flow meter. By substituting the data into the correction information, from the general flow rate estimation information, in the blood pump actual machine “describe the relationship between the motor rotation speed, the motor current consumption and the blood pump flow rate in the blood pump actual machine 10 and the liquid attribute data. The flow rate estimation information created by performing the step of creating the flow rate estimation information,
  Based on the values N, I, and Z obtained by measuring the rotational speed N of the motor in the blood pump actual machine 10 embedded in the patient's body, current consumption I of the motor, and attribute data Z of the patient's blood, blood A method for estimating a flow rate of a blood pump, wherein the flow rate Q of the pump is estimated.   A blood pump flow rate estimation method for estimating the flow rate Q of the blood pump in the actual blood pump 10 embedded in the patient's body based on the motor rotation speed N, the motor current consumption I, and the patient blood attribute data Z. There,
  General flow rate including correction information by measuring the flow rate of the blood pump when the motor rotation speed, motor current consumption, and test liquid attribute data are changed in each of the plurality of blood pumps using a flow meter. A step of creating estimated information, measurement data on the rotation speed of the motor, current consumption of the motor and attribute data of blood of the patient in the blood pump actual machine 10 embedded in the body of the patient, and measurement data on the flow rate of the blood pump Is substituted into the correction information, and from the general flow rate estimation information, “the flow rate describing the relationship among the motor rotation speed, the motor current consumption, the blood pump flow rate, and the liquid attribute data in the blood pump actual device 10 in the blood pump actual device 10. The flow rate estimation information created by performing the step of creating the “estimation information” And,
  Based on the values N, I, and Z obtained by measuring the rotational speed N of the motor in the blood pump actual machine 10 embedded in the patient's body, current consumption I of the motor, and attribute data Z of the patient's blood, blood A method for estimating a flow rate of a blood pump, wherein the flow rate Q of the pump is estimated. In the blood pump flow rate estimation method according to claim 1 or 2 ,
A blood pump flow rate estimation method, wherein the motor is a DC motor. In the blood pump flow rate estimation method according to any one of claims 1 to 3 ,
The attribute data, the flow rate estimation method of a blood pump, which is a viscosity and density. In the blood pump flow rate estimation method according to claim 4 ,
A blood pump flow rate estimation method for estimating a blood pump flow rate using "converted viscosity and converted density" obtained by converting a hematocrit value of a patient's blood as the attribute data Z of the patient's blood . In the blood pump flow rate estimation method according to any one of claims 1 to 5 ,
A blood pump flow rate estimation method, wherein the blood pump is a blood pump having a mechanical seal portion for sealing a shaft of a motor rotation shaft. In the blood pump flow rate estimation method according to any one of claims 1 to 6 ,
A blood pump flow rate estimation method, wherein the flow rate estimation information is a flow rate estimation formula. In the blood pump flow rate estimation method according to any one of claims 1 to 6 ,
The blood pump flow rate estimation method, wherein the flow rate estimation information is a flow rate estimation table. A method for creating flow rate estimation information used to implement the blood pump flow rate estimation method according to claim 1,
General flow rate including correction information by measuring the flow rate of the blood pump when the motor rotation speed, motor current consumption, and test liquid attribute data are changed in each of the plurality of blood pumps using a flow meter. Creating estimation information;
In the blood pump 10, the number of rotations of the motor, current consumption of the motor, and attribute data of the test solution are measured, the flow rate of the blood pump is measured using a flow meter, and the obtained measurement data is substituted into correction information. From the general flow rate estimation information, “the flow rate estimation information describing the relationship among the motor speed, the motor current consumption, the blood pump flow rate, and the liquid attribute data in the blood pump actual device 10” in the blood pump actual device is created. A method for creating flow rate estimation information. A method for creating flow rate estimation information used for performing the blood pump flow rate estimation method according to claim 2,
General flow rate including correction information by measuring the flow rate of the blood pump when the motor rotation speed, motor current consumption, and test liquid attribute data are changed in each of the plurality of blood pumps using a flow meter. Creating estimation information;
In the blood pump 10 embedded in the patient's body, the rotation number of the motor, the current consumption of the motor, the measurement data about the blood attribute data of the patient, and the measurement data about the flow rate of the blood pump are substituted into the correction information, and Step of creating “the flow rate estimation information describing the relationship between the motor speed, the motor current consumption, the blood pump flow rate, and the liquid attribute data in the blood pump actual device 10” in the blood pump actual device from the general flow rate estimation information A method for creating flow rate estimation information, comprising: A method for creating general flow rate estimation information used to implement the blood pump flow rate estimation method according to claim 1 or 2,
By measuring with a flow meter the flow rate of the blood pump when the respective changing the attribute data of the rotational speed and the motor current consumption and the test liquid in the motor in each of the plurality of blood pumps, the general including the correction information A method for creating general flow rate estimation information, characterized by creating flow rate estimation information.

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