JP5351350B1 - PTP packaging body packaging sheet and PTP packaging body using the same - Google Patents

Abstract

Provided is a packaging sheet for a lid material of a PTP packaging body, which can prevent the coating layer from peeling off from the aluminum foil and wear of the punching blade due to titanium oxide in the coating layer.
A packaging sheet 1 for a lid material of a PTP packaging body includes a printed layer 5 on a front surface side or a back surface side of an aluminum foil 2, and a first coating layer 3 containing titanium oxide on the front surface or the back surface of the aluminum foil 2. And a second coating layer 4 containing titanium oxide at a higher content than the first coating layer 3 thereon, and a printing layer 5 thereon.
[Selection] Figure 1

Description

  The present invention relates to a packaging sheet for a lid material suitable for a lid material of a PTP package used for packaging pharmaceutical products such as tablets.

  A PTP package (press-through pack) is often used for packaging pharmaceutical products such as tablets and capsules. The PTP package is, for example, individually stored in a recess in a bottom made of vinyl chloride and covered with a lid made of aluminum foil or the like.

  As this lid material, for example, there is one in which letters, figures, symbols, etc. are directly printed on the surface of an aluminum foil, and an overprint (OP) layer for protecting the printing is formed thereon. This printing displays invariant information such as product name, price, efficacy and effect, and variable information such as date of manufacture, lot number, and expiration date. The information may be displayed as a one-dimensional code (bar code) or a two-dimensional code (QR code (registered trademark)) including the information.

If the printing is performed directly on the aluminum foil like this lid material, there is a problem in visibility such as the printing becomes difficult to see due to the influence of the ground or reflection of the aluminum foil. Therefore, a cover material for a press-through pack has been developed in which a coating layer colored with white or the like is formed on an aluminum foil to conceal the background of the aluminum foil, and printing is performed thereon (see Patent Document 1 below). ).
In addition, a PTP packaging lid packaging sheet has been developed in which a transparent or translucent underlayer is provided between the aluminum foil and the white colored layer, and the difficulty in reading barcodes due to reflection of the aluminum foil is eliminated. (See Patent Document 2 below).

Japanese Patent Laid-Open No. 10-24944 JP 2008-174302 A

  As described above, in order to improve the visibility and reading of barcodes, printing is often performed by providing a coating layer colored white or the like on an aluminum foil. At that time, titanium oxide is often used as a white pigment. In addition, even when coloring in other colors, titanium oxide may be included for coloration. In order to enhance the whiteness in order to improve the printing visibility and barcode reading, etc., the content of titanium oxide in the coating layer is increased.

However, it was confirmed that the following problems occur when the content of titanium oxide in the coating layer is increased.
First, the binding force of a binder such as a resin is weakened, causing a problem that it is easy to peel from the aluminum foil.
Furthermore, since titanium oxide has hardness, when punching into a predetermined shape in a PTP packaging machine, the cutting edge of the punching blade is likely to wear, and the punching blade must be replaced at intervals of about 2 to 4 days. The problem of not becoming.

  Accordingly, the object of the present invention is to wear the punching blade when the coating layer is peeled off from the aluminum foil or the PTP package is punched while the visibility of the printed layer and the reading of the barcode are good. It is another object of the present invention to provide a packaging sheet for a lid of a PTP packaging body that can prevent the above-mentioned problem and can reduce the amount of titanium oxide used.

  The packaging sheet for lid materials of the PTP packaging body of the present invention is a packaging sheet for lid materials of PTP packaging bodies provided with a printed layer on the front surface side or back surface side of aluminum foil, and titanium oxide on the front surface or back surface of the aluminum foil. And a second coating layer containing titanium oxide at a higher content than the first coating layer, and a printed layer thereon.

The first coating layer may contain 0.1% to 25% by mass of titanium oxide per layer, and the second coating layer may contain 5% to 70% by mass of titanium oxide per layer. The second coating layer can be formed per unit area ^{0.5g / m 2 ~5.0g / m 2} .

The printing of the printing layer is preferably a one-dimensional code or a two-dimensional code, and the printing layer has a printing reflectance of preferably 50% or less of the reflectance of the second coating layer.
The PTP packaging body can be formed by using the packaging sheet for a lid material of the PTP packaging body as a lid material of a bottom material having a storage recess.

  The cover sheet for a lid material of the PTP package includes a first coating layer containing titanium oxide on the front surface or the back surface of an aluminum foil, and a titanium oxide content higher than that of the first coating layer on the first coating layer. It can be manufactured by forming a second coating layer and forming a printing layer thereon.

The packaging sheet for the lid material of the PTP package of the present invention has a coating layer having a two-layer configuration of a first coating layer and a second coating layer, so that the visibility of the printed layer, barcodes, etc. can be read. While being good, it is possible to prevent the coating layer from peeling from the aluminum foil and wear of the punching blade when the PTP package is punched. Furthermore, the amount of titanium oxide used can be reduced.
In addition, aluminum foil may slightly change the ground color depending on the heat history and the blending ratio of various components, and if the coating layer such as white is formed on the surface, the color will change slightly. was there. However, the present invention also has an effect that the color change can be prevented by forming the first coating layer on the front or back surface of the aluminum foil and forming the second coating layer thereon. Was found.

It is sectional drawing which showed typically the packaging sheet for lid | cover materials of one Embodiment of this invention. It is the side view which showed an example of the PTP package using the packaging sheet of FIG. 1 as a cover material.

  Hereinafter, the packaging sheet for lid materials of the PTP packaging body of one embodiment of the present invention will be described. However, the present invention is not limited to this embodiment.

  As shown in FIG. 1, a packaging sheet 1 for a PTP packaging body according to an embodiment of the present invention includes an aluminum foil 2, a first coating layer 3, a second coating layer 4, and a printing layer 5. And.

  A conventionally well-known thing can be used for the aluminum foil 2, Although it does not specifically limit, The hard or soft aluminum foil of thickness of about 10-30 micrometers can be used. The aluminum foil 2 has a glossy surface (mirror surface) on one side and a matte surface (matte surface) on the other surface, a glossy surface (mirror surface) on both sides, and glossy on both sides. Any of the types having a vanishing surface (mat surface) may be used.

  The first coating layer 3 can be formed on the surface of the aluminum foil 2 and can be formed on the entire surface or a part of the aluminum foil 2. In this embodiment, although the 1st coating layer 3 is formed only on the surface, it is not limited to this, It can also form on a back surface and may form on both surfaces.

The first coating layer 3 contains titanium oxide and is not particularly limited, but titanium oxide is 0.1% by mass to 25% by mass, preferably 0.1% by mass to 20% by mass, per layer. %, Particularly preferably 10% by mass to 20% by mass. If the titanium oxide content is less than 0.1% by mass, the ground color of the aluminum foil will affect the color of the surface of the coating layer. If it exceeds 25% by mass, the cutting edge of the punching blade tends to wear out. Become. In addition, this content rate is a thing at the time of drying. The titanium oxide is preferably rutile type titanium oxide.
This titanium oxide preferably has an average particle size of 0.2 μm to 0.5 μm. This average particle diameter can be measured with a laser beam type particle size distribution meter.

  The first coating layer 3 is colored, and can be colored, for example, white, red, orange, beige, pink or the like. If it contains only titanium oxide, it will be white, but if it is red, it will further contain pigments such as anthraquinone, quinacridone, diketopyrrolopyrrole, perylene, perinone, and indigoid. If it is orange, it will be diketo Add further pigments such as pyrrolopyrrole, perylene, anthraquinone (anthrone), perinone, quinacridone, and indigoid. Can be formed.

The first coating layer 3 includes, for example, a vinyl chloride resin, a nitrocellulose resin, an epoxy resin, an acrylic resin, a urethane resin, a melamine resin, an ester resin, and a vinyl acetate resin as a binder. One or a mixture of these may be included.
In order to form the 1st coating layer 3 on the aluminum foil 2, it can form by a conventionally well-known method, for example, can form by gravure printing, offset printing, UV coating, etc.
The first coating layer 3, for example, per unit area ^{0.4g / m 2 ~1.6g / m 2} , it preferably is formed by coating amount of 0.4g ^{/ m 2} ~0.8g ^/ m 2 it can. If the coating amount is less than 0.4 g / m ² , the ground color of the aluminum foil will affect the color of the coating layer surface, and if it exceeds 1.6 g / m ² , the cutting edge of the punching blade will be worn out. It becomes easy. This coating amount is that during drying.

The second coating layer 4 can be formed on the first coating layer 3 and contains titanium oxide at a higher content than the first coating layer 3. Although the 2nd coating layer 4 does not specifically limit, 5 mass%-70 mass% per layer, Preferably it contains 25 mass%-60 mass%. When the content of titanium oxide is less than 5% by mass, the white color becomes weak, and when it exceeds 70% by mass, the cutting edge of the punching blade tends to be worn. In addition, this content rate is a thing at the time of drying. The titanium oxide is preferably rutile type titanium oxide.
It is preferable to use titanium oxide having an average particle size of 0.2 μm to 0.5 μm. This average particle diameter can be measured with a laser beam type particle size distribution meter.

  The second coating layer 4 is colored, and can be colored, for example, white, red, orange, beige, pink, or the like, and is preferably the same color as the first coating layer 3. Coloring can be performed by including the pigment shown in the first coating layer 3.

The second coating layer 4 includes, for example, a vinyl chloride resin, a nitrocellulose resin, an epoxy resin, an acrylic resin, a urethane resin, a melamine resin, an ester resin, and a vinyl acetate resin as a binder. One or a mixture thereof can be contained, and the same binder as that of the first coating layer 3 is preferably used.
In order to form the 2nd coating layer 4 on the 1st coating layer 3, it can form by a conventionally well-known method, For example, it can form by gravure printing, offset printing, UV coating, etc.
The second coating layer 4, for example, per unit area ^{0.5g / m 2 ~5.0g / m 2} , it preferably is formed by coating amount of 0.5g ^{/ m 2} ~1.5g ^/ m 2 it can. When the coating amount is less than 0.5 g / m ² , the white color becomes weak, and when it exceeds 5.0 g / m ² , the cutting edge of the punching blade tends to be worn. This coating amount is that during drying.

  The printing layer 5 can be formed on the second coating layer 4, and printing includes, for example, characters, figures, symbols, and more specifically, invariant information such as product name, price, dose, efficacy and effect, etc. And variable information such as date of manufacture, lot number, expiration date, etc. can be printed. Among them, it is preferable to print a one-dimensional code (bar code) or two-dimensional code (QR code (registered trademark)) including variable information such as manufacturing date and lot number, which is individual information of the product, It is preferable to print GS1 (old RSS code), GS1-RSS limited composite symbol CC-A, GS1-RSS14 stack composite symbol CC-A, etc., which are barcodes for pharmaceuticals.

The printing layer 5 is not particularly limited, but is formed so that the reflectance of printing is 50% or less, preferably 39% or less, particularly preferably 20% or less of the reflectance of the second coating layer 4. It is preferable to do. If the reflectivity exceeds 50%, the visibility of printing becomes poor, and barcodes and the like are difficult to read.
This reflectance can be calculated 10 times using a visible semiconductor laser (wavelength 660 nm) and using the average value.

Although the printing of the printing layer 5 is not specifically limited, it is preferable to color with black, blue, or green. A conventionally well-known ink can be used for the ink used for printing of a printing layer, for example, when making printing black, the ink containing carbon black is preferable.
The printing layer 5 can be formed by a conventionally known method, for example, ink jet printing, gravure printing, or the like.

  As shown in FIG. 1, the packaging sheet 1 for a lid material of a PTP package can form a heat seal layer 6 on the back side of the aluminum foil 2, and an overprint (OP) layer on the printed layer 5. 7 can be formed.

The heat seal layer 6 is a layer for welding the packaging sheet 1 to the bottom material 8.
The heat seal layer 6 can be formed of a conventionally used PTP package heat seal layer, for example, a resin mainly composed of a mixture of the same resin as the bottom material shown below. It can be formed by applying a gravure coat using a coating agent. Coating amount of the heat seal layer 6 is not particularly limited, per unit area ^{2g / m 2 ~5g / m 2} , preferably can be formed of ^{2.5g / m 2 ~4g / m 2} .

The overprint (OP) layer 7 is a layer for protecting the print layer 5 and the like.
The overprint (OP) layer 7 can be formed by using a conventionally known overprint layer of a PTP package, for example, an OP made of a transparent resin such as nitrocellulose, acrylic, or epoxy. It can be formed by applying a coating agent by gravure coating or the like. Coating amount of overprint (OP) layer 7 is not particularly limited, per unit area ^{0.5g / m 2 ~2.5g / m 2} , preferably from 0.5g ^/ m 2 ~1.5g ^/ It can be formed with m ² . The overprint (OP) layer 7 may contain 3 to 5% by mass of a matting agent such as silicon oxide.

The lid packaging sheet 1 of the PTP package includes, for example, a first coating layer 3 containing titanium oxide formed on the surface of an aluminum foil 2 and a higher content of titanium oxide than the first coating layer 3 thereon. It can be manufactured by forming the second coating layer 4 containing at a rate and forming the printing layer 5 thereon. The heat seal layer 6 may be formed on the back surface of the aluminum foil 2, and the overprint layer 7 may be formed on the surface of the print layer 5.
When the first coating layer 3 and the second coating layer 4 are formed on both surfaces of the aluminum foil 2, for example, the heat seal layer 6 is formed on the outermost surface on the back surface side, and the outermost surface on the front surface side is overlaid. The print layer 7 can be formed.

The PTP packaging body 10 can be produced using the packaging sheet 1 for a lid material of a PTP packaging body as a lid material for the bottom material 8.
As shown in FIG. 2, the bottom material 8 has a storage recess 9 for storing a tablet or the like, and is not particularly limited, but can be formed from polyvinyl chloride, polyester, polypropylene, polyethylene, or the like. The storage recess 9 can be formed by thermoforming or the like.

  The PTP package 10 can be produced by using a conventionally known PTP packaging machine. For example, the packaging sheet 1 is laminated on the bottom material 8 in which tablets and the like are stored in the storage recesses 9 and is welded by heat sealing or the like. Thereafter, it can be manufactured by punching with a punching blade in a punching process and cutting to an appropriate size. This punching blade is made of alloy tool steel for cold mold (SKD) or the like.

Such a cover sheet 1 for a lid material of a PTP package has good visibility of the printed layer 5 and reading of a barcode, etc., but the first coating layer 3 and the second coating layer from the aluminum foil 2. The layer 4 can be prevented from peeling off. Moreover, wear of the punching blade when the PTP package 10 is punched can be prevented.
Furthermore, it is possible to obtain an equivalent symbol contrast while reducing the amount of titanium oxide used as compared with the case where titanium oxide is formed as a single layer.

  Thus, the packaging sheet for lid materials of the PTP packaging body of the present invention can prevent the coating layer from peeling from the aluminum foil and the wear of the punching blade when the PTP packaging body is punched. .

  Hereinafter, the packaging sheet for lid materials of the PTP packaging body of one Example of this invention is demonstrated. However, the present invention is not limited to this example.

(PTP package)
First, a packaging sheet for a lid material of the following PTP packaging body was produced, and a PTP packaging body was produced with a PTP packaging machine using the packaging sheet.
An 8079 hard material having a thickness of 20 μm was used as the aluminum foil of the cover sheet for the lid material of the PTP package.
The first coating layer contains a coating solution containing 30% by mass of an epoxy resin as a binder and 4% by mass of rutile titanium oxide as a white pigment, and a gravure plate having a plate depth of 20 μm on the entire surface of the aluminum foil. Printed. The content of titanium oxide after drying was 17% by mass, and the coating amount of this layer was 0.8 g / m ² . The average particle diameter of titanium oxide was 0.3 μm.

The second coating layer contains a coating solution containing 30% by mass of an epoxy resin as a binder and 7% by mass of rutile titanium oxide as a white pigment, and a plate depth of 20 μm is formed on the entire surface of the first coating layer. Printed with a gravure version. The titanium oxide content per layer after drying was 28% by mass, and the coating amount of this layer was 1.1 g / m ² . Moreover, the average particle diameter of the titanium oxide was 0.3 μm.

On the second coating layer, the pharmaceutical barcode GS1 was printed in black to form a printed layer. This printing was performed using a gravure plate having a plate depth of 20 μm, and an ink containing carbon black was used as the ink.
Next, an OP agent mainly composed of nitrocellulose was coated on the entire surface to form an overprint layer. The coating amount of this layer after drying was 0.1 g / m ² .
A heat seal agent (manufactured by DIC Graphics Co., Ltd.) was coated on the back surface of the aluminum foil to form a heat seal layer. The coating amount of this layer after drying was 0.2 g / m ² .

(Punching test)
The PTP packaging body was prepared by heat-sealing the bottom material at 220 ° C. with a PTP packaging machine (“FBP-M1 type” manufactured by CKD Corporation) using the packaging sheet for the lid material of the PTP packaging body as a lid material. In addition, as a bottom material, the brand name "Vinyl foil C for PTP" (Mitsubishi Resin Co., Ltd. product) consisting of hard vinyl chloride was used.
The PTP packaging machine was operated continuously for 5 hours per day for 1 week.

(result)
When the produced PTP package was confirmed visually, there was no coating layer peeled off from the aluminum foil.
Further, in the PTP packaging machine, troubles due to wear of the cutting edge of the punching blade did not occur.

(Reading test)
A packaging sheet for a lid material of a PTP package was produced in the same manner as described above except that the printing layer was changed as follows.
The printed layer was a barcode printed with the minimum element width shown in Table 1 below.
Using this PTP packaging body packaging sheet as a lid material, heat-sealing the bottom material at 220 ° C. or 240 ° C. with a PTP packaging machine (“FBP-M1 type” manufactured by CKD Corporation). Ten pieces were produced. In addition, as a bottom material, the brand name "Vinyl foil C for PTP" (Mitsubishi Resin Co., Ltd. product) which consists of hard vinyl chloride was used.

  The barcode information of this PTP package was read by a barcode verifier (camera verifier and laser verifier) Label Vision System LVS9510-5, and a reading test was performed.

  Table 1 below shows the evaluation results of the readability evaluated by the verification machine. Further, the evaluation score ranges (according to The American National Standards Institute = ANSI standard) of the evaluation classes (stages) in the following Table 1 are as follows. In addition, an evaluation score is an average value of ten pieces.

(Evaluation classification by evaluation points)
A (excellent) 3.5-4.0
B (excellent) 2.5-3.4
C (good) 1.5-2.4
D (possible) 0.5-1.4
F (impossible) 0.0 to 0.4

Moreover, the following packaging sheets for lid materials of PTP packaging bodies were produced, and the PTP packaging body was produced with the PTP packaging machine using it.
The same thing as the above was used as an aluminum foil of the packaging sheet for lid materials of a PTP package.
A coating solution containing 30% by mass of an epoxy resin as a binder and 30% by mass of rutile-type titanium oxide as a white pigment as a coating layer on the aluminum foil was prepared, and a plate depth of 20 μm was formed on the entire surface of the aluminum foil. Printed with a gravure version. The content per layer of titanium oxide after drying was 70% by mass, and the coating amount of this layer was 1.7 g / m ² . Moreover, the average particle diameter of the titanium oxide was 0.3 μm.
A barcode having the minimum element width shown in Table 2 below was printed as a printing layer on the coating layer.
This printing was performed using a gravure plate having a plate depth of 20 μm, and an ink containing carbon black was used as the ink.
An overprint layer was formed on the printed layer in the same manner as described above, and a heat seal layer was formed on the back surface of the aluminum foil in the same manner as described above.

Using the PTP packaging body packaging sheet as a lid material, heat seal the bottom material at 220 ° C. with a PTP packaging machine (“FBP-M1 type” manufactured by CKD Corporation) to produce 10 PTP packaging bodies each. did. In addition, as a bottom material, the brand name "Vinyl foil C for PTP" (Mitsubishi Resin Co., Ltd. product) consisting of hard vinyl chloride was used.
The bar code information of this PTP package was read by a bar code verifier (camera type verifier) Label Vision System LVS9510-5, and a reading test was performed.
Table 2 below shows the evaluation results of the readability evaluated by the camera type verification machine.

(result)
The PTP package in which the first coating layer and the second coating layer are formed on the aluminum foil has the same barcode reading evaluation as compared with the case where a single coating layer is formed on the aluminum foil. It was a thing. However, the amount of titanium oxide used when the first coating layer and the second coating layer are formed is about 0.44 mg, and the amount of titanium oxide used when a single coating layer is formed is about 1 .2 mg, and the same reading evaluation could be obtained while reducing the amount of titanium oxide used.

DESCRIPTION OF SYMBOLS 1 ... PTP packaging body cover sheet 2 ... Aluminum foil 3 ... First coating layer 4 ... Second coating layer 5 ... Printing layer 6 ... Heat seal layer 7 ... Overprint (OP) layer 8 ... Bottom material 9. Storage recess 10 ... PTP package

Claims (10)

  A packaging sheet for a lid material of a PTP packaging body provided with a printing layer on the front surface side or the back surface side of an aluminum foil, the first coating layer containing titanium oxide on the front surface or the back surface of the aluminum foil, and a first coating thereon A packaging sheet for a lid of a PTP packaging body, comprising: a second coating layer containing titanium oxide at a higher content than the coating layer; and a printed layer thereon.   The packaging sheet for a lid material for a PTP packaging body according to claim 1, wherein the first coating layer contains 0.1% by mass to 25% by mass of titanium oxide per layer.   The packaging sheet for lid materials for PTP packaging bodies according to claim 1 or 2, wherein the second coating layer contains 5% by mass to 70% by mass of titanium oxide per layer. The second coating layer, the cover material for a packaging sheet of PTP packaging according to any of claims 1 to 3, which is formed by the unit area per ^{0.5g / m 2 ~5.0g / m 2} .   The packaging sheet for a lid of a PTP package according to any one of claims 1 to 4, wherein the printing of the printing layer is a one-dimensional code or a two-dimensional code.   The packaging sheet for a lid material of a PTP packaging body according to any one of claims 1 to 5, wherein a reflectance of printing of the printing layer is 50% or less of a reflectance of the second coating layer.   The PTP package which used the packaging sheet for lid materials of the PTP packaging body in any one of Claims 1-6 for the lid material of the bottom material which has an accommodation recessed part.   A first coating layer containing titanium oxide is formed on the front or back surface of the aluminum foil, and a second coating layer containing titanium oxide at a higher content than the first coating layer is formed thereon, on which The manufacturing method of the packaging sheet for lid materials of the PTP package which forms a printing layer.   A first coating layer containing titanium oxide is formed on the front or back surface of the aluminum foil, and a second coating layer containing titanium oxide at a higher content than the first coating layer is formed thereon, on which Method for preventing peeling of coating layer by forming printed layer and forming packaging sheet for lid material of PTP package, pasting this packaging sheet as lid material of bottom material, and punching said packaging sheet with a punching blade . A first coating layer containing titanium oxide is formed on the front or back surface of the aluminum foil, and a second coating layer containing titanium oxide at a higher content than the first coating layer is formed thereon, on which A punching blade wear prevention method in which a printed layer is formed to form a packaging sheet for a lid material of a PTP package, the packaging sheet is bonded as a bottom material lid material, and then the packaging sheet is punched with a punching blade.

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