JP5322454B2 - Spouted bed granulator - Google Patents

Description

  The present invention relates to a spouted bed granulator that forms a granulated product by adhering powders to each other.

Conventionally, for example, a spouted bed granulation method is known as a dry granulation method. In this method, the raw material powder (adhesive powder) is contained in a vertical cylindrical container whose lower part is tapered and narrow, and a high-speed gas is jetted from below to jet the powder. Form a layer.
The spouted bed has a structure in which the powder is spouted upward in the vicinity of the central axis of the granulating apparatus, and the powder descends and circulates around the powder.
In the spouted bed granulation method, the size of the powder is determined by the contact between the powders in the jet flow in which the powders are blown up by the gas, and the bonding of the powders for the purpose of rolling the powder on the inner surface of the container. The optimization is repeated and a granulated product having a desired particle size is formed.

  In the spouted bed type granulation method, a binder that can be an impurity is not used, and the powders are bonded together using only the adhesive force of the adhesive powder. For this reason, the spouted bed granulation method is expected to be applied in the pharmaceutical and food fields where impurities are a problem.

  In order to produce pharmaceuticals, foods, etc. using this method, the processing efficiency becomes a problem. In the spouted bed granulation method, the particle size and processing capacity of the powder are determined by the balance between the upward flow rate of the powder in the granulator and the rolling effect of the powder on the inner surface of the container. Seem. However, the optimum conditions for setting the structure of the granulator and the flow rate of the gas supplied to the jet part have not been established yet.

  Accordingly, an object of the present invention is to provide a spouted bed granulating apparatus for efficiently granulating adhesive powder.

In order to achieve the above object, the first characteristic configuration of the spouted bed granulating apparatus according to the present invention includes a gas outlet provided in a lower part of a casing, a perforated plate provided above the gas outlet, and the perforated plate. A granulation chamber provided with a jet part formed above and a sloping part adjacent to the perforated plate and having an inner diameter expanding upward, and a flow rate of the gas flowing through the perforated plate, the central part of the perforated plate A flow velocity distribution generating means that can be set low toward the peripheral edge, and the flow velocity distribution generating means has a tapered shape in which the inner diameter is reduced toward the gas ejection port below the perforated plate. The flow velocity distribution generating means is configured such that the aperture ratio of the perforated plate is configured such that the central portion is larger than the peripheral portion .

  When the powder is spouted at the jet part by jetting the gas flow from the gas jet port upward from the opening of the perforated plate, for example, when the gas is jetted upward at the center of the jet part, the powder is The flow is changed in the outer direction at the upper part of the housing which is jetted up and decreases in the rising speed, and then a downward flow is formed along the inner surface of the casing.

In this configuration, the flow rate distribution generating means is provided above the perforated plate so that the gas flow rate is high in the central portion of the perforated plate and the flow rate is low in the peripheral portion. As a result of suppressing the gas rising speed at the peripheral edge of the perforated plate in this way, it is possible to satisfactorily form a circulating flow that descends along the inner surface of the housing and passes through the inclined portion toward the jet portion again. In this circulating flow, the powders are bonded and bonded by contact or collision between the powders, and the powders are appropriately compacted by rolling on the inner surface of the casing or the inclined surface of the inclined part. At the same time, the shape itself is adjusted to a spherical shape. As a result, the powder can be efficiently granulated without using a binder.
Therefore, in this structure, the granulated material which has a desired particle size and intensity | strength can be obtained by setting appropriately the gas flow velocity distribution in a jet part by a flow velocity distribution generation means.

As in this configuration, the shape of the housing is tapered so that the inner diameter is reduced toward the gas ejection port below the perforated plate, so that when the ejected gas passes through the tapered portion, the gas expands to some extent. Although it reaches the perforated plate, the flow rate is inevitably suppressed on the outer peripheral side of the gas flow due to the influence of contact with the surrounding gas and entrainment of the surrounding gas due to the ejection compared to the central part. . Therefore, when passing through the perforated plate, the flow velocity at the peripheral portion is lower than the flow velocity at the central portion. As a result, it is possible to satisfactorily form a circulation flow in the granulation chamber while suppressing the gas rising speed at the peripheral edge.

As in this configuration, when the opening ratio is increased on the center side of the perforated plate, due to the difference in pressure loss when the gas passes through the holes of the perforated plate, the center side of the perforated plate The gas flow velocity can be set high, and the air flow velocity can be set low on the peripheral edge side. In the case of this configuration, it is possible to form a jet region having a higher flow velocity toward the center side above the porous plate without changing the jetting state or the jetting position of the airflow from the gas jetting port to the porous plate. Therefore, an optimum airflow velocity distribution can be formed regardless of the gas jetting means.

In order to achieve the above object, the second characteristic configuration of the spouted bed granulating apparatus according to the present invention includes a gas outlet provided in a lower part of a casing, a perforated plate provided above the gas outlet, and the perforated plate. A granulation chamber provided with a jet part formed above and a sloping part adjacent to the perforated plate and having an inner diameter expanding upward, and a flow rate of the gas flowing through the perforated plate, the central part of the perforated plate A flow velocity distribution generating means that can be set low toward the peripheral edge, and the flow velocity distribution generating means has a tapered shape in which the inner diameter is reduced toward the gas ejection port below the perforated plate. A throttle part that restricts the flow diameter of the gas passing through the perforated plate and loosens the inclination angle of the inclined part at the peripheral part of the perforated plate, adjacent to the inclined part. It is in.

When the powder is spouted at the jet part by jetting the gas flow from the gas jet port upward from the opening of the perforated plate, for example, when the gas is jetted upward at the center of the jet part, the powder is The flow is changed in the outer direction at the upper part of the housing which is jetted up and decreases in the rising speed, and then a downward flow is formed along the inner surface of the casing.

In this configuration, the flow rate distribution generating means is provided above the perforated plate so that the gas flow rate is high in the central portion of the perforated plate and the flow rate is low in the peripheral portion. As a result of suppressing the gas rising speed at the peripheral edge of the perforated plate in this way, it is possible to satisfactorily form a circulating flow that descends along the inner surface of the housing and passes through the inclined portion toward the jet portion again. In this circulating flow, the powders are bonded and bonded by contact or collision between the powders, and the powders are appropriately compacted by rolling on the inner surface of the casing or the inclined surface of the inclined part. At the same time, the shape itself is adjusted to a spherical shape. As a result, the powder can be efficiently granulated without using a binder.
Therefore, in this structure, the granulated material which has a desired particle size and intensity | strength can be obtained by setting appropriately the gas flow velocity distribution in a jet part by a flow velocity distribution generation means.

As in this configuration, the shape of the housing is tapered so that the inner diameter is reduced toward the gas ejection port below the perforated plate, so that when the ejected gas passes through the tapered portion, the gas expands to some extent. Although it reaches the perforated plate, the flow rate is inevitably suppressed on the outer peripheral side of the gas flow due to the influence of contact with the surrounding gas and entrainment of the surrounding gas due to the ejection compared to the central part. . Therefore, when passing through the perforated plate, the flow velocity at the peripheral portion is lower than the flow velocity at the central portion. As a result, it is possible to satisfactorily form a circulation flow in the granulation chamber while suppressing the gas rising speed at the peripheral edge.

According to this configuration, the gas ejected from the gas ejection port has a greater influence on the peripheral edge side due to the resistance when passing through the perforated plate due to the throttle portion. As a result, a jet region having a higher gas flow rate toward the center is formed above the perforated plate. As a result, the circulation flow in the granulation chamber can be formed satisfactorily, and the granulation efficiency can be increased.
  Moreover, when the throttle part loosens the inclination angle of the inclined part, the rolling effect at the inclined part is further improved, adhesion and compaction of the powders are promoted, and a good granulated product can be obtained.

A third characteristic configuration of the spouted bed granulation apparatus according to the present invention is provided with a nozzle communicating with a gas supply pipe provided below the casing as the flow velocity distribution generating means, and the opening of the nozzle is formed in the perforated plate. It exists in the point arrange | positioned below the center and above the said gas supply pipe | tube.

As in this configuration, by arranging the nozzle below the center of the perforated plate and above the gas supply pipe, the gas ejected from the nozzle is concentrated in the vicinity of the center of the perforated plate so that the air flows to the periphery. The amount can be reduced. Therefore, also in this configuration, similarly to the above configuration, the flow velocity distribution when passing through the perforated plate can be set high near the center and low at the peripheral portion.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.
The spouted bed granulator of the present invention forms a granulated product by adhering powders together.

[Embodiment 1]
1 and 2 are schematic views of the spouted bed granulator X.
The spouted bed granulation apparatus X includes a granulation chamber 30 and a flow velocity distribution generating means 40 that can set the flow velocity of the gas spouted from the perforated plate 20 to be lower from the central portion toward the peripheral portion of the perforated plate 20. The granulation chamber 30 is located in the lower part of the vertical cylindrical casing 60 for jetting gas, and is located above the gas outlet 10 in the casing 60 and faces the gas outlet 10. The porous plate 20 and the gas from the gas outlet 10 pass through the apertures 21 provided in the porous plate 20, so that the powder A is spouted above the porous plate 20, and the powder A is spouted up. Is composed of a jet part 31 that moves down along the inner surface of the housing 60, and an inclined part 32 that is adjacent to the jet part 31 and the perforated plate 20 so that the powder A rolls, and whose inner diameter expands upward.

(powder)
In the spouted bed granulation apparatus X of the present invention, granulation is possible if the powder itself is an adherent powder having adhesive force. The adhesion force is, for example, intermolecular force or adhesive force. In this way, by using only the adhesive force of the powder itself, granulation can be performed without using a binder that can be an impurity.

(Gas outlet)
The gas ejection port 10 is provided at the lower part of the housing 60 and ejects gas upward along the central axis Z of the porous plate 20 and the jet part 31.
The gas outlet 10 is connected to a gas supply pipe 11, and the gas supply pipe 11 is connected to a gas supply source, a flow control valve, a humidity controller, a flow meter, and the like. Thereby, it can comprise so that flow volume, humidity, a pressure, etc. can be adjusted. As the gas, for example, an inert gas such as nitrogen gas (N ₂ ) having low reactivity is preferably used because of the relationship with the powder as a raw material.

(Perforated plate)
The perforated plate 20 is mounted below the granulation chamber 30. A large number of apertures 21 are provided in the perforated plate 20. In the present embodiment, the same opening 21 is arranged uniformly over the entire surface of the porous plate 20. For the perforated plate 20, for example, a 325 mesh stainless steel wire mesh is used.
As the perforated plate 20, a porous plate having such a size that the powder can be placed on the upper portion and having a small pressure loss when passing through the gas, in other words, having a large open rate is preferable.

(Granulation means)
The granulation chamber 30 is a jet section 31 that spouts the powder A above the perforated plate 20 by a gas flow from the gas ejection port 10 and lowers the sprayed powder A along the inner surface of the housing 60, and An inclined portion 32 that is adjacent to the perforated plate 20 and whose inner diameter expands upward is provided.

The jet part 31 is provided inside the housing 60. The casing 60 of this embodiment is made of transparent acrylic for the purpose of observing the inside, and has an inner diameter of 100 mm.
In the jet part 31, the powder A is spouted along the central axis Z of the jet part 31 by the gas flow ejected from the gas outlet 10 through the opening 21 of the porous plate 20, and the gas and the powder A An upward flow is formed. Next, the sprayed powder A changes its flow in the outward direction due to a decrease in the rising speed of the airflow in the upper part of the housing 60, and a downward flow is formed along the inner surface of the housing 60.

  The inclined portion 32 is formed below the housing 60 and has a tapered inclined surface. Since the inclined portion 32 is adjacent to the porous plate 20, the powder A can roll in the vicinity of the porous plate 20 when the powder A descends from the jet portion 31. At this time, while rolling on the inclined surface of the inclined portion 32, the powder collides with the contact, adheres and is bonded and consolidated. Thereafter, the powder A reaches the central portion of the perforated plate and is blown up by the upward flow, and then circulates again and reaches the inclined portion 32. By repeating this cycle, the powder A grows into a granular granulated product B.

  Note that a bag filter for preventing leakage of the powder A to the outside when the gas is discharged to the outside of the housing is mounted on the upper portion of the housing 60. The surface of the inclined portion 32 is attached with a Teflon (registered trademark) processed tape to prevent adhesion of powder A and the like.

(Velocity distribution generation means)
The flow velocity distribution generating means 40 is configured so that the flow velocity of the gas ejected to the jet portion 31 can be set lower at the peripheral portion of the porous plate 20, that is, at a position close to the inclined portion 32 than the central portion of the porous plate 20. .
At this time, the relative flow velocity of the gas flow increases at the center of the perforated plate 20 and decreases at a position close to the inclined portion 32. As a result of suppressing the gas rising speed in the vicinity of the peripheral edge located on the outer peripheral side of the perforated plate 20 as described above, it is possible to satisfactorily form a circulating flow that descends along the housing 60 and goes to the jet portion 31 through the inclined portion 32. Can do. At this time, the powder A is agglomerated and bonded by contact or collision between the powders A and rolls on the wall surface of the casing 60 or the inclined surface of the inclined portion 32, whereby the powder A is appropriately compacted and the shape itself Is also arranged in a spherical shape. As a result, the powder can be efficiently granulated without using a binder.

  Therefore, by appropriately setting the flow velocity distribution of the gas passing through the porous plate 20 by the flow velocity distribution generating means 40, the granulated product B having a desired particle size and strength can be obtained efficiently.

In the present embodiment, the flow velocity distribution generating means 40 is adjacent to the rolling part 32 and has a tapered casing lower portion formed such that the gas inlet diameter in the granulation chamber 30 is larger than the gas outlet diameter in the gas outlet 10. 41.
According to the present configuration, the shape of the casing lower portion 41 is tapered such that the inner diameter is reduced toward the gas ejection port 10 below the perforated plate 20 so that the gas ejected from the gas ejection port 10 is tapered. When passing through the lower portion 41, the gas reaches the porous plate 20 while expanding to some extent, but the outer peripheral side of the gas flow is in contact with the surrounding gas or involving the surrounding gas due to ejection, compared to the central portion. Inevitably, the flow velocity will inevitably be reduced. Therefore, when passing through the perforated plate 20, the flow velocity at the peripheral portion is lower than the flow velocity at the central portion. As a result, it is possible to satisfactorily form a circulation flow in the granulation chamber 30 while suppressing the gas rising speed at the peripheral edge.

Using the powder A processed by the spouted bed granulator X of the present invention, granulation was performed under the following conditions. Specifically, the size of the porous plate 20 on which the adhesive powder A as a raw material was placed was variously changed.
The casing 60 has a tapered shape having the same inclined surface from the granulation chamber 30 above the perforated plate 20 to the lower gas ejection port 10, the taper angle is 20 °, and the opening diameter of the gas ejection port 10 is It was 8 mm. In Example 1, the outer diameter (D) of the porous plate 20 is 25 mm, the height (H) from the opening surface of the gas outlet 10 is 6 cm, and in Example 2, the outer diameter (D) is 50 mm and the height ( H) was 14 cm. Further, as a comparative example, the granulation process was performed also in the case where the porous plate 20 was attached to the opening (d) of the gas ejection port 10 and the porous plate 20 was not attached in the housing 60.

  As the powder A, lactose (manufactured by Frieslandfoods) used as an excipient in a powder inhalation preparation was used. As a pretreatment, in order to remove agglomerates of the powder A, the powder A was passed through a sieve having an aperture of 1.4 mm in advance. Thereafter, a predetermined amount was filled on the porous plate 20. Table 1 shows the conditions for the granulation treatment.

  Next, in order to evaluate the granulated state under each condition, the shape, particle size distribution, and fluidized state during granulation of the obtained granulated product B were examined. The shape of the granulated product B was observed with a microscope, the particle size distribution was evaluated with a manual sieve specified by JIS, and the fluidized state was visually evaluated.

The measurement results of the particle size distribution are shown in FIG. 7 ((a): Comparative example, (b): Example 1, (c): Example 2).
The result of a granulation process is shown to Tables 2-4. Table 2 shows the results of the comparative example, Table 3 shows the results of Example 1, and Table 4 shows the results of Example 2.
The recovery rate was calculated by the granulated material recovery amount (g) × 100 ÷ raw material filling amount (g), and the fluidization state was classified into the following three types.
(* 1) Immediately after the start of granulation, a good fluidized state was obtained by giving a light impact to the outer wall near the upper part of the perforated plate 20.
(* 2) In addition to the operation of * 1, a good fluidized state was obtained by breaking the adhesive powder layer near the inner wall of the granulation chamber 30 above the porous plate 20 with a thin rod.
(* 3) Even when the operations of * 1 and * 2 were performed, channeling or slugging occurred.

In each of Examples 1 and 2 and the comparative example, the raw material filling amount was changed with the filling height as a target.
In Examples 1 and 2 and the comparative example, the filling height of the raw material was set to 3 cm, 7 cm, and 10 cm. In Example 1, when the filling height was 15 cm, a normal spouted layer could not be formed. This is the same amount of filling as that in Example 2 where the filling height is 10 cm, and this is to confirm the influence of the filling height on the spouted bed. Incidentally, in the comparative example, it was difficult to form the spouted layer when the filling height was 11 cm.
From the measurement results of the particle size distribution shown in FIG. 7, in Example 1 (outer diameter (D): 25 mm), a substantially good spouted bed is formed in all cases where the filling height is 3 cm, 7 cm, and 10 cm. . However, when the filling height was 15 cm (hereinafter referred to as “HB15”), a good spouted layer could not be formed.
As a result, in all other conditions, about 70% of the recovered granulated product B having a size of 1000 μm or less exists, whereas in the condition of the raw material filling height of 15 cm, the recovered granulated product B having a size of 1000 μm or less is Only about 40% was present.
In Example 2 (outer diameter (D): 50 mm), a good spouted layer is formed in any case where the filling height is 3 cm, 7 cm, or 10 cm.

Except for Example 2 and HB15 of Example 1, a good spherical granulated product B was formed (FIG. 8A). From this, it is considered that a good spouted layer was formed under these conditions.
On the other hand, in HB15 of Example 1, a relatively large non-spherical granulated product B was formed (FIG. 8B). From this, under this condition, it is considered that a bubble fluidized bed was formed rather than a normal spouted bed.
From the above, in order to increase the throughput of raw materials, increase the recovery rate, and obtain a good granulated product, the aeration area of the porous plate 20 is increased, and the jet part 31 and the circulation part are provided on the porous plate 20. It has been suggested that it is effective to secure a space for forming the material well and keep the filling of the raw material within a predetermined filling height range.
On the other hand, it was found that in the comparative example, when the filling height is other than 3 cm, the processing amount and the recovery rate are not sufficient, and it is difficult to form a good spouted bed.

[Embodiment 2]
In the above-described embodiment, the case where the gas ejection port 10 is coupled to the gas supply pipe 11 and gas is directly ejected from the gas supply pipe 11 has been described. In addition, it is possible to provide another nozzle 12 for ejecting gas to the gas supply pipe 11 (FIG. 3). At this time, the flow velocity distribution generating means 40 is arranged such that the opening of the nozzle 12 is located at a position below the central portion of the porous plate 20 and close to the porous plate 20 above the gas supply pipe 11, in other words, with the nozzle 12. It is configured by taking an appropriate interval between the perforated plate 20.
By arranging the opening of the nozzle 12 below the center of the perforated plate 20 and above the gas supply pipe 11, the gas ejected from the nozzle 12 is concentrated at the center of the perforated plate 20, The amount of ventilation to the peripheral edge can be suppressed. Therefore, also in this configuration, similarly to the above configuration, the flow velocity distribution when passing through the perforated plate can be set high near the central portion and low at the peripheral portion.
Thereby, it is possible to satisfactorily form a circulation flow in the granulation chamber 30 while suppressing the gas rising speed at the peripheral edge of the perforated plate 20.

[Embodiment 3]
In the above-described embodiment, a case has been described in which the hole diameter of the opening 21 in the porous plate 20 is formed to be uniform over the entire surface of the porous plate 20. However, it is not limited to this. For example, the aperture ratio of the perforated plate 20 itself can be formed so as to be different between the central portion and the peripheral portion of the perforated plate 20 so that the aperture ratio of the central portion is larger than that of the peripheral portion. Specifically, in the case where the opening ratio is larger at the center side of the porous plate 20 than at the peripheral side, the difference in pressure loss when the gas passes through the opening 21 of the porous plate 20. Thus, the gas flow rate can be set high on the central side of the perforated plate 20 and the gas flow rate can be set low on the peripheral side.

  Moreover, it is possible to form so that the hole diameter of the said opening 21 may differ in the center part side and the peripheral part side of the perforated panel 20 (FIGS. 4 and 5). In this case, the hole diameter of the opening 21 is configured to decrease from the central portion toward the peripheral portion.

In order to make the hole diameter of the opening 21 different between the central part side and the peripheral part side of the perforated plate 20, as shown in FIG. 4, the central part mesh 22 and the peripheral part which are meshes (net bodies) having different pore diameters. The mesh 23 may be combined. In this case, the diameter of the opening 21 of the central mesh 22 is set to be larger than the diameter of the opening 21 of the peripheral mesh 23 in a range where the powder A does not fall from the mesh. Each of the meshes 22 and 23 is formed so that the hole diameter of the opening 21 is uniform over the entire surface.
According to this configuration, the gas flow rate can be set high on the central side of the perforated plate 20, and the gas flow rate can be set low on the peripheral side. In the case of this configuration, it is possible to form a jet region having a higher flow velocity toward the central portion in the upper part of the porous plate 20 without changing the jet state or the position of the air flow from the gas jet port 10 to the porous plate 20. . Therefore, an optimum airflow velocity distribution can be formed regardless of the gas jetting means.
In addition, the center part mesh 22 and the peripheral part mesh 23 are comprised so that attachment or detachment to the frame 24 is possible, and it can replace | exchange suitably for the mesh which has a desired internal diameter.

[Embodiment 4]
It is possible to provide the casing 60 with a throttle portion 50 that restricts the flow diameter of the gas passing through the porous plate 20 and has a gentler inclination angle than the inclined portion 32 outside the peripheral edge portion of the porous plate 20 ( FIG. 6).
In this configuration, the inclined portion 32 is formed on the surface of the throttle portion 50. According to this configuration, the flow velocity of the gas ejected from the gas ejection port 10 is reduced at the central portion and the peripheral portion of the porous plate 20 by the flow diameter of the gas being reduced by the throttle portion 50. . That is, the throttle portion 50 acts as an orifice with respect to the gas, and the flow velocity of the gas increases toward the center side above the porous plate 20.
As a result, the circulation flow in the granulation chamber 30 can be formed well, and the granulation efficiency can be increased.
Further, by setting a tapered surface with a slanting angle closer to that of the inclined portion 32 adjacent to the inclined portion 32 in the throttle portion 50, the rolling effect at the inclined portion 32 is further improved, and adhesion between powders is reduced. Consolidation is promoted and a good granulated product can be obtained.

  INDUSTRIAL APPLICATION This invention can be utilized for the spouted bed granulation apparatus which adheres powder and forms a granulated material.

Schematic diagram of spouted bed granulator of the present invention The principal part schematic of the spouted bed granulation apparatus of Embodiment 1 The principal part schematic of the spouted bed granulation apparatus of Embodiment 2. Schematic of the porous plate of Embodiment 3 Schematic diagram of essential parts of the spouted bed granulating apparatus of Embodiment 3. Main part schematic of spouted bed granulation apparatus of Embodiment 4 Figure showing particle size distribution measurement results The figure which showed the photograph of the granulated material

Explanation of symbols

X spouted bed granulator A powder B granulated product 10 gas outlet 12 nozzle 20 perforated plate 21 aperture 30 granulating chamber 31 spouting portion 32 inclined portion 40 flow velocity distribution generating means 41 lower case 50 narrowing portion 60 housing

Claims (3)

A gas outlet provided at the lower part of the housing, a perforated plate provided above the gas outlet, a jet formed above the perforated plate, and an inclination that is adjacent to the perforated plate and whose inner diameter expands upward A granulation chamber with a section;
A flow rate distribution generating means capable of setting a flow rate of the gas that passes through the perforated plate to be lower from a central portion toward a peripheral portion of the perforated plate,
The flow velocity distribution generating means, the shape of the housing, the perforated plate than Ri tare and tapered inner diameter is reduced toward the gas ejection port below, said flow velocity distribution generating means, the perforated plate the porosity, structure and tear Ru spouted bed granulator so that the central portion is greater than the peripheral portion. A gas outlet provided at the lower part of the housing, a perforated plate provided above the gas outlet, a jet formed above the perforated plate, and an inclination that is adjacent to the perforated plate and whose inner diameter expands upward A granulation chamber with a section;
A flow rate distribution generating means capable of setting a flow rate of the gas that passes through the perforated plate to be lower from a central portion toward a peripheral portion of the perforated plate,
The flow velocity distribution generating means, the shape of the housing, the perforated plate than toward the gas ejection port at the lower and tapered to reduce the inner diameter tare is, the peripheral portion of the perforated plate, the inclined portion And a spouted bed granulating apparatus comprising a constricted part that restricts the flow diameter of gas passing through the perforated plate and loosens the inclination angle of the inclined part. The flow velocity distribution generating means is provided with a nozzle communicating with a gas supply pipe provided below the housing, and an opening of the nozzle is disposed below the center of the perforated plate and above the gas supply pipe. The spouted bed granulator according to claim 1 or 2 .