JP5300315B2 - Inhaler - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To prevent liquid droplets from colliding with each other and resultant change of a liquid droplet size and the denaturation of medical solutions from occurring in the central portion where the flow rate of the airflow becomes the maximum inside an airflow path. <P>SOLUTION: Inside an inhalation flow path 2a of a flow path mouthpiece unit 2 having a mouthpiece 4 at one end, a cylindrical structure 3 is disposed, and the cross-section of the inhalation flow path 2a is made ring-shaped. The surface of the structure is provided with a plurality of medicine ejection heads 6, and the medicinal liquids are supplied from a medicine tank 7 provided in the inside of the structure 3. Even when the plurality of medicine ejection heads 6 are simultaneously driven, the liquid droplets can be prevented from colliding with one another to change the liquid droplet size and the like. <P>COPYRIGHT: (C)2009,JPO&amp;INPIT

Description

  The present invention relates to an inhalation device that allows a user to inhale a liquid or the like containing an active ingredient used for respiratory system disease treatment or the like.

  An ink jet technique is known as one of methods for discharging a liquid sample into fine droplets. The ink jet system has a feature that it shows high controllability even in a very small amount with respect to the amount of liquid discharged after being formed into droplets. As an ink jet type fine droplet discharge method, a vibration method using a piezoelectric element or the like, and a thermal ink jet method using a micro heater element are known. In the thermal ink jet method, it is relatively easy to reduce the size of the micro heater element to be used, and the number of discharge ports provided per unit area can be increased as compared with the vibration method using a piezoelectric element or the like. . Further, the cost required for the production can be made much lower.

  Many spraying devices spray multiple substances rather than spraying a single composition. It is used in various ways such as spraying drugs and adjuvants, or multiple drugs, and drugs are also used in a wide range of compounds, fragrances, and pigments for therapeutic purposes.

  Conventionally, when spraying a plurality of substances, a method of mixing a plurality of substances in order to establish a single operation has been taken, but a problem may occur. As long as they exist individually, if they exist in the same atmosphere as other substances, the state changes and the properties may change. Examples of the driving force for the above-described phenomenon include interactions between ions and charges, interactions that dissolve hydrogen bonds, and actions associated with π conjugation. In addition, there are various combinations in which the pot life is long or short.

  In spraying the plurality of substances, the mechanism of mixing the liquid just before spraying is seen in the conventional spraying method, but the droplets collide with each other to increase the particle size and make fine droplets, In addition, it remains a problem that the amount cannot be precisely controlled (see Patent Document 1 and Patent Document 2).

  Although an example in which a plurality of types of chemical liquids are ejected by an ink jet method can be seen, a specific configuration of a mechanism for preventing collision of droplets is not described (see Patent Document 3).

  There are also inhalers in which two medicines that cannot be stored in one canister in an aerosol-type inhaler are housed in different canisters, and a plurality of medicines can be inhaled by a user (Patent Document 4, Patent Document). 5, see Patent Document 6).

WO2002 / 05898 WO2004 / 007346 Publication USP 6684880 WO 2004/011069 WO 2004/011070 WO2004 / 011071

  When a liquid medicine is discharged to an air flow path connected to a mouthpiece (mouthpiece) and the user inhales it, if liquid is discharged from a plurality of discharge heads in one inhalation, There is a risk of droplets colliding. Normally, the flow velocity of the airflow in the flow path is the smallest near the outer wall of the flow path and the largest in the central part of the flow path, so even if liquid is ejected from multiple locations, droplets concentrate in the central part of the flow path As a result, the liquid droplets collide with each other at the central portion where the flow velocity of the air current is maximum. Since the site to be deposited in the lung differs depending on the inhaled drug solution, a preferable droplet diameter is determined. Therefore, it is not preferable that the droplet diameter changes due to the collision of the droplets. Further, when different kinds of chemical liquids are discharged, there is a possibility that the chemical liquid may be denatured by the collision of the chemical liquid droplets.

  The present invention is capable of controlling the amount of droplets sprayed in an airflow with high accuracy in an inhaler or the like used for medical purposes, and in addition, the ejected droplets collide with each other to increase the particle size. It is an object of the present invention to provide an inhalation device that can prevent this from happening.

An inhalation device of the present invention is an inhalation device for discharging a medicine to cause a user to inhale, a mouthpiece part for a user to inhale a medicine, one end connected to the mouthpiece part, and the other end An air flow path having an air intake and guiding the drug to the suction port by an air flow generated by inhalation by a user; a plurality of drug discharge sections for discharging the drug to the air flow path; possess the arranged structure, to the plurality of the medicine ejection portion is a surface of the structure, when the length of the air flow path is L, respectively from both ends of said structure It is arranged in a range away from L / 5 along the air flow path .

  By arranging the structure in the air flow path, it is possible to prevent the discharged droplets from colliding with each other and increasing the droplet diameter even when the drugs are simultaneously discharged from the plurality of drug discharge portions.

  Therefore, in each spray operation, it is possible to administer a drug that can be used for a plurality of treatment purposes at a predetermined concentration and with an arbitrary ratio with high accuracy and with high reproducibility.

  The best mode for carrying out the present invention will be described with reference to the drawings.

  1 and 2 are an external perspective view and a cross-sectional view showing the first embodiment. This is a portable inhaler, in which a flow path mouthpiece unit 2 is attached to a housing case 1. One end of the flow mouthpiece unit 2 is provided with a mouthpiece 4 which is a mouthpiece, and the other end has an air flow in an air flow path 2a which is a space inside the flow mouthpiece unit 2 when a user inhales. The air inlet is formed so as to generate air. The structure 3 is held by the support 3a inside the flow channel mouthpiece unit 2. A hook claw 5 is provided on a side surface of the flow channel mouthpiece unit 2 so as to be connected to the housing case 1. A plurality of ejection heads (medicine ejection units) 6 are provided on the surface of the structure 3, and a drug tank 7 (see FIG. 3) that is a container for storing a chemical liquid ejected from the ejection head 6 is provided inside the structure 3. Is provided. The medicine tank 7 communicates with the ejection head 6 in order to supply the medicine to the ejection head 6. The flow mouthpiece unit 2 has an electrical connection surface 8 and is supplied with electric power via an electrical connection member 9 disposed in the housing case 1.

  The user holds the mouthpiece 4 of the flow path mouthpiece unit 2. The housing case 1 has a battery 10, a menu switching button 11 for the user to set, a setting up button 12, a down button 13, a decision button 14, a display unit 15 for performing dosage, time, error display, and the like. Etc. are provided.

  The arithmetic circuit and the memory 16 are provided on the control substrate 18 and store data such as a medicine discharge condition, a discharge amount, and time. The electric power for driving them is supplied from a rechargeable battery 10 as a secondary battery.

  Further, in order to efficiently inhale the medicine, it is preferable to synchronize the user's inhalation and the droplet ejection. Therefore, a pressure sensor 17 is provided on the control board 18 as an inhalation detection sensor in order to detect inhalation of the user and start ejection based on the inhalation detection signal. The pressure sensor 17 detects a negative pressure generated in the flow path by the user's inhalation. The channel mouthpiece unit 2 is provided with a communication hole 2 b that communicates with the air channel 2 a, and the communication hole 2 b communicates with the pressure sensor 17 via the pressure detection tube 19.

  The presence of such a structure 3 in the air flow path can reduce the possibility that liquid droplets ejected from a plurality of ejection heads collide. This point will be described with reference to FIG. FIG. 11 (a) schematically shows a cross-sectional view of a conventional air flow path 2a that does not have the structure 3 in the air flow path. In this case, the velocity of the air flow generated by the user's inhalation is slow near the inner wall of the flow channel mouthpiece unit 2 and is fastest near the center of the air flow channel. A line indicated by a bold line in the air flow path in the figure indicates this as an image. The right diagram in FIG. 11A is a cross-sectional view of the air flow path 2a, and the central point represents the fastest airflow velocity. Here, when the medicine is ejected from the plurality of ejection heads 6, the ejected liquid droplets tend to concentrate near the center of the air flow path 2 a and reach the mouthpiece 4 as shown by the arrows in the figure. There is a possibility that the droplets will collide with each other.

  On the other hand, FIG.11 (b) is sectional drawing of the air flow path 2a provided with the structure 3 of this invention. In this case, the maximum point of the flow velocity of the airflow generated by the user's inhalation is not concentrated at one point. That is, it becomes slow on the surface of the structure 3 and the inner wall surface of the flow path mouthpiece unit 2 and becomes fastest near the intermediate point. A line indicated by a bold line in the air flow path in the figure indicates this as an image. The right diagram in FIG. 11B is a cross-sectional view of the air flow path 2a, and the portion indicated by the dotted line is the place where the flow velocity of the airflow is the fastest. Here, if the medicine is ejected from the plurality of ejection heads 6, the droplets are concentrated in the vicinity of the location closest to the ejected location, among the locations where the flow velocity is maximized. For this reason, the probability that the droplets discharged from the plurality of discharge heads 6 collide with each other can be reduced. This is the same whether the plurality of ejection heads 6 are provided inside the structure 3 or the inner wall of the flow channel mouthpiece unit 2 as illustrated.

  Thus, the structure 3 of the present invention is a structure having such a shape that the maximum point of the flow velocity of the airflow does not become one point but can be dispersed.

  FIG. 3 shows only the flow mouthpiece unit 2, (a) is a cross-sectional view of the flow mouthpiece unit 2 in the axial direction, and (b) is a cross-sectional view taken along line AA of (a). is there. A hook claw 5 for connecting to the housing case 1 is provided at the lower part. Considering the usability of attaching / detaching the flow mouthpiece unit 2, it is desirable that the hook claw 5 has a simple structure. In addition, an electrical connection surface 8 that supplies power to each ejection head 6 via the support 3 a of the structure 3 is provided. The shape of the air flow path 2a of the flow mouthpiece unit 2 having a ring-shaped cross section by providing the structure 3 does not have to be a perfect circle. For example, an elliptical shape is the same for avoiding collision of discharged liquid droplets. There is an effect.

  The discharge head 6 and the medicine tank 7 are set in a one-to-one correspondence. The user attaches the flow channel mouthpiece unit 2 containing the discharge chemical solution to the housing case 1 in the drug tank 7. Subsequently, the user operates the menu switching button 11 for setting, the setting up button 12, the down button 13, and the determination button 14 to set the amount of medicine. When the user presses the discharge start button, the chemical liquid stored in the drug tank 7 is discharged from the surface of the structure 3 from the discharge head 6 toward the flow channel outer wall (the inner wall of the flow channel mouthpiece unit 2). The

  In the present embodiment, a thermal ink jet type ejection head in which fine liquid droplet ejection ports are arranged at high density is used as the ejection head. This is a discharge head having an electrothermal conversion element that applies heat to a chemical solution as a discharge energy generating element for discharging the chemical solution. According to this method, the total number of fine droplets ejected per unit area and time can be set and controlled with high accuracy, and the total amount of droplets ejected can be controlled with high accuracy. In addition, it is a liquid ejecting means suitable for the purpose of ejecting with good reproducibility.

  And by arranging a plurality of ejection heads, it is possible to spray a plurality of types of medicines. At that time, by disposing a plurality of ejection heads on a structure provided in the air flow path, the plurality of ejection heads are operated in one operation, and a plurality of types of drugs or a plurality of same types of drugs are sprayed in one operation. It becomes possible. For example, the former can increase the efficiency of treatment by spraying drugs that dilate the bronchi and insulin that reaches the lungs and regulates blood sugar levels. The latter can reduce the number of times a drug is administered to a patient with a large amount of drug and can contribute to improvement of the patient's QOL (Quality of Life).

  The cross section of the air flow path having the structure perpendicular to the air flow has a ring shape, a plurality of drug tanks are provided inside the structure, and a plurality of discharge heads are arranged on the surface of the structure. The cross section orthogonal to the airflow that is in the shape of a ring may be a rectangular closed ring shape with corners, but a closed ring shape without corners is most preferred. In the case of a cross section that is not closed, it is desirable that the ratio of the long side length to the short side length is sufficiently large so that the flow velocity distribution is not a dot shape but a linear shape.

  Moreover, it is preferable that the support body holding the structure is streamlined so as not to disturb the flow of the airflow. In order to prevent the discharged droplets from colliding with each other and increasing the droplet diameter, the droplets discharged from a plurality of discharge heads when viewed in a cross section perpendicular to the annular airflow. More preferably, the assembly is arranged so as not to be divided by the support.

  The material of the channel mouthpiece unit may be any material, but is preferably a material selected from glass, plastic, and metal.

  In the case of having a plurality of chemical tanks, a combination of a chemical solution and a flavor component or a flavoring component liquid is possible as a combination other than a plurality of chemical solutions. The main medium of the liquid to be discharged is preferably water or an organic substance, and more preferably water is the main medium when administered to a living body.

  The drugs used in the present invention include not only pharmaceutical compounds having pharmacological and physiological effects, but also ingredients for flavor, fragrance, dye, pigment, etc. in addition to pharmaceutical compounds. It is a concept.

  Moreover, the chemical | medical solution used for this invention says the liquid medium containing a liquid chemical | medical agent or a chemical | medical agent. The chemical solution may contain any additive. The state of the drug in the liquid may be any of dissolution, dispersion, emulsification, suspension, and slurry. Moreover, it is better if it is uniform in the liquid.

  When a chemical solution is used as a drug, the main medium of the liquid is preferably water or an organic substance, and water is preferably the main medium in consideration of administration to a living body.

  The droplet discharge method may be any of a piezoelectric actuator method and an ultrasonic method as a vibration method, and a thermal ink jet method using thermal energy as a negative pressure method. Note that the negative pressure type is superior to the vibration type for controlling the amount of sprayed droplets with high accuracy.

  In particular, it is preferable that a large number of liquid agent discharge units having discharge heads based on the thermal ink jet principle can be driven independently. For the selection of the method, the manufacturing cost, unit price, integration density, and the like can be cited as criteria, and it is more preferable to use a method in which thermal energy is applied and foamed from the above two points.

  In addition, an operation command can be sent in a relay manner to sequentially operate a plurality of ejection heads in one operation, and a movable command can be sent simultaneously. The relay time difference can be arbitrarily set, and a time difference larger than the operating time of the discharge head that operates first may be set.

  FIG. 4 shows a second embodiment. As shown in FIGS. 4B and 4C, the cross-sectional shape of the air flow path 2a and the structure 3 of the flow path mouthpiece unit 2 is rectangular so that no gap is formed when it is held in the mouth. A mouse spacer 20 is provided. The other points are the same as in the first embodiment. The structure 3 that accommodates the ejection head 6 has the advantage that the rectangular shape is easier to manufacture and less expensive than the circular shape.

  FIG. 5 shows a third embodiment. As shown in FIGS. 5B, 5C, and 5D, the cross section of the air flow path 2a and the structure 3 of the flow path mouthpiece unit 2 is rectangular, and has a portion 2c that does not become an air flow path. That is, the part which becomes a flow path has a "C" shape. By having the part 2c which does not become a flow path, the electrical wiring of the discharge head 6 becomes easy. And the mouse | mouth spacer 20 is comprised similarly to 2nd Embodiment.

  As shown in FIG. 5 (d), the communication hole 2b for viewing the negative pressure inside the air flow path 2a opens horizontally in an L shape. The other points are the same as in the first embodiment. Since the third embodiment includes a pressure sensor for detecting the negative pressure generated in the air flow path when the user inhales, the inhalation and the discharge start can be synchronized. Since the user does not need to press the medicine discharge button, the convenience is improved.

  FIG. 6 shows a fourth embodiment. The cross section of the air flow path 2a is circular, and the cross section of the structure 3 is rectangular and closed. Further, as shown in FIG. 7, a plurality of ejection heads 6 can be arranged on one side of the structure 3 depending on the dimensions of the structure 3 and the ejection heads 6. The ejection head 6 and the medicine tank 7 are connected one to one. The other points are the same as in the first embodiment.

  FIG. 8 shows a fifth embodiment. In this case, a chemical solution is supplied from one chemical tank 7 to a plurality (eight) of ejection heads 6a to 6h. (C) of FIG. 8 shows the piping diagram of the chemical | medical agent tank 7 and the discharge heads 6a-6h. Since each of the ejection heads 6a to 6h ejects the liquid by thermal energy or vibration energy, the liquid is ejected by the surface tension of the ejection ports of the ejection heads 6a to 6h without providing a stop valve between the medicine tank 7 and the ejection head 6. Can be held.

  Since the same chemical solution can be discharged from a plurality of discharge heads, it is suitable for inhalation by an elderly person or an infant whose breathing is shallow.

  FIG. 9 shows a sixth embodiment. This supplies a chemical | medical solution from the two chemical | medical agent tanks 7a and 7b to several (eight) discharge heads 6a-6h. (C) of FIG. 9 is a figure which shows the piping of chemical | medical agent tank 7a, 7b and discharge head 6a-6h. In the present embodiment, as a combination other than a plurality of chemical solutions, a combination of a chemical solution and a liquid of a savory component or a flavoring component is also possible, which has an effect of reducing psychological avoidance and burden on the user.

  FIG. 10 shows a seventh embodiment. In the present embodiment, the plurality of discharge heads 6 a to 6 h are arranged so as to discharge the chemical solution from the outer wall of the air flow path toward the structure 3. The discharge heads 6a to 6h and the medicine tank 7 are connected one-on-one.

(Preferred embodiment of the structure 3)
Here, an embodiment of a preferable structure for realizing the collision prevention of droplets, which is an effect of the present invention, will be described with reference to FIG. Hereinafter, the “position of the ejection head 6” refers to the position in the air flow direction (the left-right direction in FIG. 12A) in the air flow path.

  It is preferable that at least the air flow path 2a and the structure 3 exist at the position of the discharge head 6. That is, the discharge head 6 is disposed in the area inside the air flow path 2a and extending the structure 3 therein. Hereinafter, on the basis of the position of the ejection head 6, the air intake side may be referred to as the upstream of the air flow, and the mouthpiece side may be referred to as the downstream of the air flow.

  A preferred positional relationship between the end of the structure 3 and the air flow path 2a on the downstream side of the airflow will be described. It is most desirable that the structure 3 always exists upstream of the air flow path 2a so that the end of the structure 3 coincides with the end of the air flow path 2a. When the structure 3 exists partway in the air flow path 2a, assuming that the length of the air flow path 2a is L, a point L-5 inside from the end of the air flow path 2a (point A in FIG. 12A). It is preferable that the end of the structure 3 exists on the mouthpiece side. If there is an end of the structure 3 inside the point A, depending on the flow velocity of the airflow, there is a possibility that the droplets discharged from the plurality of discharge heads 6 may merge before reaching the mouthpiece. is there. The end of the structure 3 may protrude from the end of the air flow path 2a, that is, the structure 3 may protrude from the mouthpiece, but it should not be in the way of the user's inhalation. There is. The length from which the structure 3 protrudes is preferably about L / 10.

  The preferred positional relationship between the end of the structure 3 and the air flow path 2a on the upstream side of the airflow is not particularly limited, but is preferably the same as that on the downstream side. In this case, the position corresponding to the A point is the B point.

  Next, a more preferable position of the ejection head 6 will be described. On the upstream side of the air flow, either or both of the distance x1 from the end of the air flow path 2a to the discharge head 6 and the distance y1 from the end of the structure 3 to the discharge head 6 is greater than L / 5. Is preferred. The reason is that airflow is likely to be turbulent near the air intake port or near the end of the structure, and if there is an ejection head at that position, there is a possibility that droplets may enter the turbulent flow.

  Similarly, on the downstream side of the air flow, either or both of the distance x2 from the end of the air flow path 2a to the discharge head 6 and the distance y2 from the end of the structure 3 to the discharge head 6 is from L / 5. Is also preferably large.

  When the structure 3 is provided only inside the air flow path 2a, as shown in FIG. 12B, one or both of the front and rear ends of the structure 3 are conical rather than columnar. It is preferable that If the cross-sectional area of the structure 3 decreases in a stepwise manner as it approaches the end of the air flow path 2a when viewed in a cross section perpendicular to the air flow, the turbulence of the air flow at the end of the structure 3 It is because it is hard to produce.

(About the position of multiple ejection heads)
It is not preferable to provide a plurality of heads upstream and downstream of the airflow so that the plurality of ejection heads are in the same position when viewed in a cross section perpendicular to the airflow in the air flow path. This is because droplets ejected from a plurality of ejection heads pass through the same airflow. As shown in the embodiments so far, it is preferable that the positional relationship in which the plurality of ejection heads are arranged is shifted when viewed in this cross section. Most preferably, they are provided symmetrically at equal intervals when viewed in this cross section.

  In the first to seventh embodiments, specific examples of preparation and measurement methods of the liquid to be discharged will be described.

  First, two types of dissolution solutions for dissolving the drug were prepared. The contents are shown below. A solution for discharge was prepared by selecting a solution according to the drug.

Liquid A: Arginine hydrochloride 10 mg / ml aqueous solution Liquid B: Benzalkonium chloride 10 mg / ml aqueous solution Chemical liquid type Dissolved solution Set concentration Particle size Insulin A 0.4% 3.0
DPP4 inhibitor B 0.1% 3.1

  In each of the embodiments, a necessary discharge liquid is contained in a medicine tank, and the liquid is subjected to a predetermined voltage, frequency, and duty (ratio of time during which voltage is applied in one cycle time). Was discharged. And the particle size distribution of the discharge liquid was measured using the particle size distribution meter (Malvern company make; Spraytec). In addition, the discharged droplets were collected and a calibration curve based on the concentration was created in advance for each substance using a high performance liquid chromatograph (manufactured by JASCO; LC-2000), and the concentration of the two substances was measured and identified. . As a judgment standard, a particle size within the range of ± 0.2 μm, which is a difference between a value immediately after ejection and a value measured at the mouthpiece outlet, and a concentration within ± 0.2% were determined to be OK. The measurement results are shown in Table 1.

  From Table 1, it can be seen that the particle size and concentration are maintained in any combination when a plurality of liquids are ejected simultaneously.

It is an external appearance perspective view which shows 1st Embodiment. It is sectional drawing which shows the apparatus of FIG. FIG. 2 shows only the flow channel mouthpiece unit of the apparatus of FIG. 1, (a) is an axial sectional view, and (b) is a sectional view taken along line AA of (a). The rectangular flow-path mouthpiece unit by 2nd Embodiment is shown, (a) is sectional drawing of an axial direction, (b) is sectional drawing seen from the AA line of (a), (c). These are sectional drawings seen from the BB line of (a). The C-shaped channel mouthpiece unit by 3rd Embodiment is shown, (a) is sectional drawing of an axial direction, (b) is sectional drawing seen from the AA line of (a), (c ) Is a cross-sectional view taken along line BB in (a), and (d) is a cross-sectional view taken along line CC in (a). The channel mouthpiece unit by 4th Embodiment is shown, (a) is sectional drawing of an axial direction, (b) is sectional drawing seen from the AA line of (a). The flow-path mouthpiece unit by 5th Embodiment is shown, (a) is sectional drawing of an axial direction, (b) is sectional drawing seen from the AA line of (a). The channel mouthpiece unit by 6th Embodiment is shown, (a) is sectional drawing of an axial direction, (b) is sectional drawing seen from the AA line of (a), (c) is a piping diagram It is. The channel mouthpiece unit by 7th Embodiment is shown, (a) is sectional drawing of an axial direction, (b) is sectional drawing seen from the AA line of (a), (c) is a piping diagram It is. The channel mouthpiece unit by 8th Embodiment is shown, (a) is sectional drawing of an axial direction, (b) is sectional drawing seen from the AA line of (a). In the schematic cross-sectional view of the air flow direction of the air flow path, the arrow from the discharge head represents the movement direction of the discharged droplets, and the thick line in the air flow path is a line that represents the flow velocity distribution of the air flow. FIG. 11A is a schematic cross-sectional view showing the movement of the liquid droplet in the air flow path having no structure, and FIG. 11B is a schematic cross-sectional view showing the movement of the liquid droplet in the air flow path having the structure. The structure of an air flow path is shown, (a) is a schematic cross-sectional view for explaining the positional relationship between the air flow path, the structure, and the ejection head, and (b) is a case where the end of the structure is conical. It is a schematic cross section which shows.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Housing case 2 Flow path mouthpiece unit 2a Air flow path 2b Communication hole 3 Structure 4 Mouthpiece 5 Hook claw 6, 6a-6h Discharge head 7, 7a, 7b Drug tank 8 Electrical connection surface 9 Electrical connection member 10 Battery 11 Menu Switch button 12 Up button 13 Down button 14 Enter button 15 Display unit 17 Pressure sensor 18 Control board 19 Pressure detection tube 20 Mouse spacer

Claims (7)

In an inhalation device for injecting a medicine and causing a user to inhale,
A mouthpiece for the user to inhale the medicine;
One end is connected to the mouthpiece, the other end has an air intake, and an air flow path that guides the medicine to the mouthpiece by an air flow generated by a user's inhalation,
A plurality of medicine ejection sections for ejecting medicine to the air flow path;
Have a, a structure disposed in said air flow path,
The plurality of medicine ejection portions are surfaces of the structure, and when the length of the air flow path is L, they are separated from both ends of the structure by L / 5 along the air flow path. An inhalation device, characterized in that it is arranged within a range .   The inhaler according to claim 1, wherein the air flow path in which the structure is disposed has a ring-shaped cross section. Inhalation device according to claim 1 or 2, characterized in that the reservoir containing medicament into the interior of the structure was placed.   The inhaler according to any one of claims 1 to 3, wherein a plurality of the drug tanks are provided, and a drug solution is supplied from the plurality of drug tanks to the plurality of drug discharge units, respectively.   The inhaler according to claim 4, wherein a plurality of types of drug solutions are stored in the plurality of drug tanks.   The inhaler according to any one of claims 1 to 5, wherein the medicine ejection unit has an ejection head that ejects medicine by applying thermal energy or vibration energy. The structure is disposed so as to extend in the direction of the mouthpiece portion from a position where at least the plurality of medicine discharge portions are disposed in the air flow path from the air intake port to the mouthpiece portion. The inhaler according to any one of claims 1 to 6 .

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