JP5261290B2 - Automatic analyzer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an autoanalyzer reducing the falling of dewing water into the reagent container housed in a reagent housing. <P>SOLUTION: The autoanalyzer is equipped with: the first and second reagent dispensing probes 23 and 27 penetrating into first and second reagent containers 13 and 14 from the opening parts 131 and 141 thereof to suck first and second reagents; and the reagent housing 17 housing the first and second reagent containers 13 and 14. The reagent housing 17 has: a reagent case 33 for housing the first and second reagent containers 13 and 14; a reagent cover 34 for covering the reagent case 33 having through-holes 39-42 into which the first and second reagent dispensing probes 23 and 27 penetrate; and the guide members 39-42 internally coming into contact with the through-holes 35-38 and guiding the dewing water produced in the through-holes 35-38 to drip the same on the areas outside the opening parts 131 and 141 of the first and second reagent containers 13 and 14 housed in the reagent housing 17. <P>COPYRIGHT: (C)2011,JPO&amp;INPIT

Description

  The present invention relates to an automatic analyzer for analyzing components contained in a liquid, and more particularly, an automatic analyzer equipped with a reagent storage for storing reagents for analyzing components contained in body fluids such as human blood and urine. The present invention relates to an analyzer.

  The automatic analyzer is intended for biochemical test items, immunological test items, etc., and changes in color and turbidity caused by the reaction of the mixture of the test sample collected from the sample and the reagent of each test item are measured with a spectrophotometer. Optical data is measured by a photometric unit such as a turbidimeter or an nephelometer, thereby generating analysis data represented by concentrations of various test item components in the test sample, enzyme activities, and the like.

  In this automatic analyzer, after a reagent container containing a reagent for each inspection item is stored in the reagent container, the inspection item selected according to the inspection is analyzed. Then, the test sample is sucked from the sample container containing the test sample to be inspected by the sample dispensing probe and discharged to the reaction container. Further, the reagent is aspirated from the reagent container in the reagent storage by the reagent dispensing probe and discharged to the reaction container. Then, the liquid mixture of the test sample and the reagent discharged into the reaction container is measured by the photometry unit.

  By the way, a reagent container containing a reagent for a test item that can be analyzed is stored in a reagent store, and the stored reagent container is kept cold to prevent the reagent from being denatured. This reagent storage is provided with a reagent cover for preventing cold air from escaping out of the storage, and the reagent cover is provided with a through hole into which the reagent dispensing probe enters in order to suck the reagent. The reagent container is provided with a through-hole into which the reagent dispensing probe enters in order to suck the reagent.

  In this reagent storage, condensation easily occurs at the through hole due to a temperature difference between the inside of the reagent storage and the outside air. Then, there is a problem that condensed dew condensation water falls from the through-hole, and the dew condensation water falls into the reagent container from the opening, and the reagent in the reagent container is contaminated or diluted. In order to solve this problem, an automatic analyzer including a reagent storage having an inclined surface inside the reagent cover is known (for example, see Patent Document 1).

JP-A-8-262030

  However, when the inclination angle of the inclined surface inside the reagent cover of the reagent storage of Patent Document 1 is small, condensed water drops may fall from a position in the middle of the inclined surface and fall into the reagent container. Further, when the inclination angle is large, there is a problem that the reagent cover is increased in thickness and the reagent storage is enlarged.

  The present invention has been made to solve the above problems, and an object of the present invention is to provide an automatic analyzer that can reduce the fall of condensed water into a reagent container housed in a reagent store.

In order to achieve the above object, the automatic analyzer of the present invention according to claim 1 is an automatic analyzer for dispensing a sample and a reagent contained in a reagent container having an opening into a reaction container and measuring the mixed solution. in the analyzer, the reagent case for housing the pre-Symbol reagent container, reagent cover for have a through hole, covers the reagent case reagent dispensing probe to aspirate a reagent from the reagent container enters porous derivative for dropping the reagent storage and, inscribed in the through hole, the opening portion outside of the reagent container leading the condensed water stored in the reagent storage to occur in the through-hole having, when And the derivative has an opening that penetrates, and the opening of the derivative is configured by an inclined surface that forms part of a conical side surface that increases in diameter as it approaches the inside of the reagent storage. At the lower end of the derivative Diameter of the mouth is characterized by longer than the diameter of the opening of the reagent container.

Also, the automatic analyzer of the present invention according to claim 2, the reagent contained in the reagent container having a sample and opening dispensed into the reaction vessel min, the automatic analyzer for measuring the mixture, prior Symbol a reagent case for accommodating the reagent container, reagent storage having a reagent cover for reagent dispensing probe have a through hole that enters, to cover the reagent case to suck the reagent from the reagent container When the inscribed in the through-hole having a hydrophilic derivatives for dropping into the opening outsider of the reagent container leading the condensed water stored in the reagent storage to occur in the through hole, wherein The derivative has an opening that penetrates, and the opening of the derivative is configured by an inclined surface that forms a part of a conical side surface that increases in diameter as it approaches the inside of the reagent container, and the lower end of the derivative The diameter of the opening in And wherein the longer than the diameter of the opening of the container.

Furthermore, the automatic analyzer of the present invention according to claim 4, the reagent contained in the reagent container having a sample and opening dispensed into the reaction vessel min, the automatic analyzer for measuring the mixture, prior Symbol a reagent case for accommodating the reagent container, reagent storage having a reagent cover for reagent dispensing probe have a through hole that enters, to cover the reagent case to suck the reagent from the reagent container When the inscribed in the through-holes, have a, a derivative having a groove formed for dropping into the opening outsider of the reagent container leading the condensed water stored in the reagent storage to occur in the through-hole The derivative has an opening therethrough, and the opening of the derivative is connected to a plurality of upper end portions and lower end portions that form part of a conical side surface that increases in diameter as it approaches the inside of the reagent storage. It is composed of an inclined surface in which the groove is formed. Diameter of the opening portion at the lower end of said derivative is characterized by longer than the diameter of the opening of the reagent container.

  According to the present invention, by placing the derivative for guiding the condensed water generated in the through hole of the reagent cover and dropping it outside the opening of the reagent container housed in the reagent container, The fall of condensed water can be reduced.

1 is a block diagram showing a configuration of an automatic analyzer according to Embodiment 1 of the present invention. The perspective view which shows the structure of the analysis part which concerns on Example 1 of this invention. The top view which shows arrangement | positioning of the reagent storage of the analysis part which concerns on Example 1 of this invention, the 1st and 2nd reagent rack, the reaction disk, and the 1st and 2nd reagent dispensing arm. The figure which shows the external appearance of the 1st and 2nd reagent container which concerns on Example 1 of this invention. FIG. 4 is a cross-sectional view of the reagent storage shown in FIG. Sectional drawing which shows an example of the derivative | guide_body which concerns on Example 1 of this invention. An opening of the first reagent container stopped at the first reagent aspirating position according to Example 1 of the present invention, an opening of, for example, two first reagent containers adjacent to the first reagent container, and an opening of the derivative The top view which shows a relationship. The figure which shows the other example of the derivative | guide_body based on Example 1 of this invention. The figure which shows the structure of the reagent storage which concerns on Example 2 of this invention. The figure which shows an example of the derivative | guide_body based on Example 2 of this invention. The figure which shows the other example of the derivative | guide_body which concerns on Example 2 of this invention.

  Examples of the present invention will be described below.

  A first embodiment of an automatic analyzer according to the present invention will be described below with reference to FIGS.

  FIG. 1 is a block diagram showing a configuration of an automatic analyzer according to an embodiment of the present invention. This automatic analyzer 100 measures a standard sample of each test item or a test sample collected from a sample and a reagent corresponding to each test item and generates standard data and test data. 10 and an analysis control unit 50 that drives and controls each analysis unit related to the measurement of the analysis unit 10.

  Further, the standard data and test data generated by the analysis unit 10 are processed to generate calibration data and analysis data, and the calibration data and analysis data generated by the data processing unit 60 are printed out. And an output unit 70 for displaying and outputting, an operation unit 80 for inputting various command signals, and the like, an analysis control unit 50, a data processing unit 60, and a system control unit 90 for controlling the output unit 70 in an integrated manner. Yes.

  FIG. 2 is a perspective view showing the configuration of the analysis unit 10. The analysis unit 10 includes a sample container 11 that stores each sample such as a standard sample and a test sample, a sample rack 12 that holds the sample container 11 so as to be movable, and one reagent system and two corresponding to each inspection item. A first reagent container 13 for storing a reagent-based first reagent and a second reagent container 14 for storing a second reagent paired with a two-reagent-based first reagent are provided.

  In addition, a reagent store 17 for storing the first and second reagent containers 13 and 14, and a first and second for rotatably holding the first and second reagent containers 13 and 14 stored in the reagent store 17. Reagent racks 15 and 16 and a reaction disk 20 that rotatably holds a plurality of reaction vessels 19 arranged on the circumference are provided.

  In addition, the sample dispensing probe 21 for dispensing the sample in the sample container 11 held in the sample rack 12 and sucking it into the reaction container 19, and the sample dispensing probe 21 can be rotated and moved up and down. The first reagent in the first reagent container 13 held in the sample dispensing arm 22 held in the first and second reagent racks 15 and 16 is aspirated and discharged into the reaction container 19 in which each sample is discharged. And a first reagent dispensing probe 23 for performing dispensing.

  In addition, a first reagent dispensing arm 24 that holds the first reagent dispensing probe 23 so as to be able to rotate and move up and down, and a first mixture that agitates each sample and first reagent discharged into the reaction container 19. A stirrer 25, a first stirrer arm 26 that holds the first stirrer 25 so that the first stirrer 25 can be rotated and moved up and down, and a second one in the second reagent container 14 held in the first and second reagent racks 15 and 16. A second reagent dispensing probe 27 is provided that dispenses the two reagents and dispenses each sample and the first reagent into the reaction container 19 from which the first reagent has been discharged.

  Further, the second reagent dispensing arm 28 that holds the second reagent dispensing probe 27 so as to be rotatable and vertically movable, and the mixed solution of each sample, the first reagent, and the second reagent in the reaction container 19 are stirred. The second stirrer 29 that rotates, the second stirrer arm 30 that holds the second stirrer 29 so that the second stirrer 29 can rotate and move up and down, and a photometric unit that optically measures the liquid mixture in the reaction vessel 19 by irradiating light 31 and a cleaning unit 32 that cleans the inside of the reaction vessel 19 that has been measured by the photometric unit 31.

  Then, the photometry unit 31 irradiates the reaction container 19 with light, and based on the detection signal for detecting the wavelength light of each inspection item that has passed through the liquid mixture containing the standard sample and the test sample in the reaction container 19, For example, standard data or test data expressed by absorbance or the amount of change in absorbance is generated. Then, the generated standard data and test data are output to the data processing unit 60.

  The analysis control unit 50 controls a mechanism unit 51 having a mechanism for driving each analysis unit of the analysis unit 10 and each mechanism of the mechanism unit 51 so that each analysis unit of the analysis unit 10 has a predetermined timing for each analysis cycle. The control part 52 act | operated by is provided.

  The mechanism 51 includes a mechanism for moving the sample rack 12 of the analyzer 10 and a mechanism for rotating the first and second reagent racks 15 and 16, respectively. Further, a mechanism for driving a pump that causes the sample dispensing probe 21 to suck and discharge the sample, a mechanism for driving a pump that causes the first reagent dispensing probe 23 to suck and discharge the first reagent, and a second reagent amount A mechanism for driving a pump that causes the probe 27 to suck and discharge the second reagent is provided.

  Further, the mechanism for rotating the reaction disk 20, the sample dispensing arm 22, the first reagent dispensing arm 24, the second reagent dispensing arm 28, the first stirring arm 26, and the second stirring arm 30 are rotated and moved up and down, respectively. A mechanism for moving, a mechanism for moving the cleaning unit 32 up and down, and the like are provided.

  The data processing unit 60 in FIG. 1 processes the standard data and test data output from the photometry unit 31 of the analysis unit 10 to generate calibration data and analysis data for each inspection item, and the calculation unit 61. And a data storage unit 62 for storing the standard data and analysis data generated in step (b).

  The calculation unit 61 generates calibration data representing the relationship between the concentration and activity of each test item component and the standard data from the standard data output from the photometry unit 31 and the standard values preset in the standard sample of the standard data. The generated calibration data is output to the output unit 70 and stored in the data storage unit 62.

  Further, the calibration data of the inspection item corresponding to the test data represented by the absorbance output from the photometry unit 31 of the analysis unit 10 is read from the data storage unit 62 and is output from the photometry unit 31 using the read calibration data. Analytical data expressed as a concentration value is generated from the test data. Further, analysis data represented as an activity value of the enzyme is generated by multiplying the test data represented by the amount of change in absorbance by a factor including a molecular extinction coefficient at a predetermined wavelength set as an analysis parameter. The generated analysis data is output to the output unit 70 and stored in the data storage unit 62.

  The data storage unit 62 includes a memory device such as a hard disk, and stores calibration data output from the calculation unit 61 for each inspection item. In addition, the analysis data of each inspection item output from the calculation unit 61 is stored for each test sample.

  The output unit 70 includes a printing unit 71 that prints out the calibration data and analysis data output from the calculation unit 61 of the data processing unit 60 and a display unit 72 that displays the output. The printing unit 71 includes a printer or the like, and prints the calibration data and analysis data output from the calculation unit 61 on printer paper or the like according to a preset format.

  The display unit 72 includes a monitor such as a CRT or a liquid crystal panel, and displays calibration data and analysis data output from the calculation unit 61. Also, an analysis parameter setting screen for setting analysis parameters for each inspection item that can be inspected by the automatic analyzer 100, a reagent information setting screen for setting information on the first and second reagents corresponding to each inspection item, A test sample information setting screen for setting identification information such as a name and ID for identifying the test sample for each test sample and an inspection item to be tested is displayed.

  The operation unit 80 includes input devices such as a keyboard, a mouse, a button, and a touch key panel, and is used to set analysis parameters, first and second reagent information, test sample identification information, test items, and the like for each test item. Perform the input operation.

  The system control unit 90 includes a CPU and a storage circuit, and includes a command signal input by an operation from the operation unit 80, analysis parameter information of each inspection item, first and second reagent information, test sample identification information, and After storing input information such as inspection item information in the storage circuit, based on these input information, the analysis control unit 50, the data processing unit 60, and the output unit 70 are integrated to control the entire system.

  Hereinafter, with reference to FIG. 1 thru | or FIG. 7, the detail of a structure of the reagent storage 17 in the analysis part 10 is demonstrated.

  First, with reference to FIG. 2 and FIG. 3, the operation | movement which dispenses a 1st and 2nd reagent with the 1st and 2nd reagent dispensing probes 23 and 27 is demonstrated.

  FIG. 3 is a plan view showing the arrangement of the reagent storage 17, the first and second reagent racks 15, 16, the reaction disk 20, and the first and second reagent dispensing arms 24, 28 of the analysis unit 10. The first reagent dispensing arm 24 rotates at the height at the upper stop position about the rotation axis when the analysis of each inspection item is performed, and dispenses the first reagent of each inspection item. The first reagent dispensing probe 23 is moved on a circular first trajectory indicated by a broken line.

  Then, the first reagent aspirating position T1 for aspirating the first reagent in the first reagent container 13 held in the first or second reagent racks 15 and 16 by the first reagent dispensing probe 23 or the first reagent aspirating. After stopping at one of the positions T2, it moves down to enter the reagent storage 17 and the first reagent container 13 stopped at one position, and the first reagent in the first reagent container 13 Stop at a height where suction is possible.

  Next, the first reagent dispensing probe 23 that has aspirated the first reagent is moved upward, and then moved to a first reagent discharge position T3 that is a position for discharging the first reagent into the reaction container 19. Then, the first reagent dispensing probe 23 discharges the first reagent into the reaction container 19 stopped at the first reagent discharge position T3.

  The second reagent dispensing arm 28 pivots about the pivot axis at a height at the upper stop position, and the second reagent dispensing probe 27 is broken in order to dispense the second reagent for each inspection item. It moves on the circular second orbit shown by.

  Then, the second reagent aspirating position T4 for aspirating the second reagent in the second reagent container 14 held by the first or second reagent racks 15 and 16 with the second reagent dispensing probe 27 or the second reagent aspirating. After stopping at one position of the position T5, it moves down to enter the reagent storage 17 and the second reagent container 14 stopped at one position, and the second reagent container 14 in the second reagent container 14 Stop at a height where suction is possible.

  Next, the second reagent dispensing probe 27 that has sucked the second reagent is moved up to one position, and then moved to the second reagent discharge position T6 where the second reagent is discharged into the reaction container 19. Then, the second reagent dispensing probe 27 discharges the second reagent that forms a pair with the first reagent into the reaction container 19 containing the first reagent stopped at the second reagent discharge position T6.

  Next, with reference to FIG. 2 thru | or FIG. 7, the detail of a structure of the reagent storage 17 is demonstrated. FIG. 4 is a diagram showing the external appearance of the first and second reagent containers 13 and 14 stored in the reagent store 17. 5 is a cross-sectional view taken along line AA of the reagent storage 17 shown in FIG. FIG. 6 is a cross-sectional view showing a part of the reagent store 17. FIG. 7 is a plan view showing the first reagent container 13 stopped at the first reagent aspirating position T1 and, for example, two first reagent containers 13 adjacent to the first reagent container 13.

  In FIG. 4, the first and second reagent containers 13 and 14 have the same shape and dimensions, respectively. The top and bottom surfaces of each of the first and second reagent containers 13 and 14 have the same shape and size, for example, a trapezoid whose longitudinal direction is the height direction between the upper and lower bases. It is made. The side surfaces of each of the first and second reagent containers 13 and 14 include an inner peripheral side surface that forms a rectangle with the upper bottom of the upper surface as one side, an outer peripheral side surface that forms a rectangle with the lower bottom of the upper surface as one side, It is comprised by the two width side surfaces which comprise the rectangle which makes the opposite side other than an upper base and a lower base one side.

  The first and second reagent dispensing probes 23 and 27 are disposed in the vicinity of the outer peripheral side surfaces of the upper surfaces of the first and second reagent containers 13 and 14 in order to aspirate the first and second reagents. Circular openings 131 and 141 having a diameter r1 that enter the reagent containers 13 and 14 are provided.

  5 is a cross-sectional view taken along line AA of the reagent storage 17 shown in FIG. The reagent store 17 includes a reagent case 33 having an opening on the upper side for housing the first and second reagent containers 13 and 14 in which the first and second reagents are accommodated, and an attachment / detachment that covers the opening of the reagent case 33. A free reagent cover 34, four derivatives 39 to 42 arranged in the reagent cover 34, and a cooler 43 that keeps the first and second reagent containers 13 and 14 stored in the reagent case 33 cool. .

  First and second reagent racks 15 and 16 are arranged in the reagent case 33. The first reagent rack 15 holds around the center C1 in a state where the first and second reagent containers 13 and 14 whose longitudinal directions are directed to the center C1 of the first reagent storage 17 are held on the circumference. The first and second reagent containers 13 and 14 are rotated in the width direction (arrangement direction) which is perpendicular to the longitudinal direction. Further, the second reagent rack 16 holds the outer periphery of the first reagent rack 15 in a state where the first and second reagent containers 13 and 14 whose longitudinal directions are directed to the center C1 are held on the circumference. The first and second reagent containers 13 and 14 are rotated in the width direction.

  The reagent cover 34 is provided to prevent the cold air from escaping out of the reagent case 33 and to prevent the outside air from flowing into the reagent case 33. Further, it is provided to suppress concentration of the first and second reagents in the first and second reagent containers 13 and 14 stored in the reagent case 33. Then, four through holes into which the first and second reagent dispensing probes 23 and 27 enter in order to aspirate the first and second reagents from the first and second reagent containers 13 and 14 stored in the reagent case 33 35 to 38.

  The through hole 35 is provided so that the first reagent dispensing probe 23 for aspirating the first reagent from the first reagent container 13 held in the first reagent rack 15 can enter the reagent storage 17. It is formed at one reagent suction position T1.

  The through hole 36 is provided so that the first reagent dispensing probe 23 for aspirating the first reagent from the first reagent container 13 held in the second reagent rack 16 can enter the reagent container 17. It is formed at one reagent suction position T2.

  The through-hole 37 is provided so that the second reagent dispensing probe 27 for aspirating the second reagent from the second reagent container 14 held in the first reagent rack 15 can enter the reagent container 17. It is formed at the two-reagent suction position T4.

  The through-hole 38 is provided so that a second reagent dispensing probe 27 for aspirating the second reagent from the second reagent container 14 held in the second reagent rack 16 can enter the reagent storage 17. It is formed at the two-reagent suction position T5.

  Each of the derivatives 39 to 42 is inscribed in each of the through holes 35 to 38 and induces condensed water generated in the through holes 35 to 38 in contact with the outside air due to a temperature difference between the inside of the reagent storage 17 and the outside air. It is provided for dripping outside the openings 131 and 141 of the first and second reagent containers 13 and 14 stored in the storage 17.

  6 is a cross-sectional view showing an example of the derivative 39 shown in FIG. The derivative 39 is made of a porous material such as a porous resin, a porous metal, or a porous ceramic for forming a porous shape in the through-hole 35, and has an opening that penetrates in the vertical direction. The opening is configured by an inclined surface 391 that forms a part of a conical side surface whose diameter increases, for example, as it gets closer to the inside of the reagent storage 17. The inclined surface 391 is an inner peripheral surface, and the outer peripheral surface is a through hole 35. Inscribed in.

  The opening 392 at the upper end of the derivative 39 is the stopping accuracy of the first reagent dispensing probe 23 moved to the first reagent suction position T1 and the position of the reagent cover 34 when the reagent cover 34 is attached to the reagent case 33. Based on the accuracy, the first and second reagent containers 13, which are the smallest diameters that allow the first reagent dispensing probe 23 stopped at the first reagent suction position T 1 to enter the reagent storage 17 without contacting the derivative 39, The apertures r1 and r2 are shorter than the aperture r1 of the 14 openings 131 and 141.

  In this way, by setting the opening 392 to have the diameter r2, the outflow of cold air to the outside of the reagent storage 17 and the inflow of outside air to the inside of the reagent storage 17 can be suppressed. Thereby, deterioration of the 1st and 2nd reagent in the 1st and 2nd reagent containers 13 and 14 accommodated in the reagent storage 17 can be prevented, and it can cool efficiently. In addition, concentration of the first and second reagents in the first and second reagent containers 13 and 14 stored in the reagent store 17 can be suppressed.

  Furthermore, the opening 393 at the lower end of the derivative 39 has a diameter r3 that is longer than the diameter r1 of the openings 131 and 141 of the first and second reagent containers 13 and 14.

  In addition, you may implement so that a porous may be formed in the inclined surface of the derivative | guide_body which consists of materials, such as resin, porous metal, and ceramics which have the same shape as the derivative | guide_body 39. FIG.

  7 shows the opening 131 of the first reagent container 13 stopped at the first reagent aspirating position T1, the openings 131 of, for example, two first reagent containers 13 adjacent to the first reagent container 13, and the opening of the derivative 39. 4 is a plan view showing a relationship with a part 393. FIG.

  The derivative 39 is disposed at a position where the opening 393 at the lower end includes the opening 131 of the first reagent container 13 stopped at the first reagent suction position T1. Moreover, it arrange | positions in the position which does not include the opening part 131 of the two 1st reagent containers 13 of both adjacent.

  By the way, the through hole 35 excluding the derivative 39 hits the upper end portion having the opening portion of the diameter r2 having the same shape and size as the opening portion of the derivative 39, the lower end portion having the opening portion of the diameter r3, and the inclined surface 391, for example Suppose that it is comprised by the slope formed by the surface and the molding surface. In this case, when the inclination angle of the inclined surface is small with respect to the horizontal plane, water droplets which have condensed and grown on the inclined surface where the inside of the reagent storage 17 is in contact with the outside air stopped at the first reagent suction position T1 along the inclined surface. The first or second reagent container 13 or 14 may fall from a grown position or a position in the middle of a slope without flowing to the lower end located above the outer periphery of the openings 131 and 141. If the position of the water drop is above the opening 131 of the first reagent container 13, there arises a problem that the first or second reagent is contaminated or diluted by the dropped water drop.

  With respect to this problem, by arranging the derivative 39 having the porous inclined surface 391 in the through hole 35, the condensed water generated in the through hole 35 is retained on the surface of the inclined surface 391. Can be hydrophilized. Then, the water droplet grown on the inclined surface 391 is guided to the lower end along the inclined surface 391 with its own weight and hydrophilicity, and stopped from the lower end to the first reagent suction position T1. It can be dropped to the outer periphery of the openings 131 and 141 of the first or second reagent containers 13 and 14. Thereby, the fall of the dew condensation water from the through-hole 35 into the 1st and 2nd reagent containers 13 and 14 can be reduced, without making the reagent cover 34 thick.

  The derivative 40 is configured in the same manner as the derivative 39 and is disposed in the through hole 36. Then, in the same manner as in the case of the derivative 39, it is led to the lower end located above the outer periphery of the opening 131, 141 of the first or second reagent container 13, 14 stopped at the first reagent aspirating position T2, and this lower end Can be dropped to the outer peripheries of the openings 131 and 141. Thereby, the fall of the dew condensation water from the through hole 36 into the first and second reagent containers 13 and 14 can be reduced without increasing the thickness of the reagent cover 34.

  The derivative 41 is configured in the same manner as the derivative 39 and is disposed in the through hole 37. Then, in the same manner as in the case of the derivative 39, it is led to the lower end located above the outer periphery of the openings 131, 141 of the first or second reagent container 13, 14 stopped at the second reagent aspirating position T4, and this lower end Can be dropped to the outer peripheries of the openings 131 and 141. Thereby, the fall of the dew condensation water from the through-hole 37 into the 1st and 2nd reagent containers 13 and 14 can be reduced, without making the reagent cover 34 thick.

  The derivative 42 is configured in the same manner as the derivative 39 and is disposed in the through hole 38. Then, in the same manner as in the case of the derivative 39, it is led to the lower end portion located above the outer periphery of the openings 131, 141 of the first or second reagent container 13, 14 stopped at the second reagent aspirating position T5. Can be dropped to the outer peripheries of the openings 131 and 141. Thereby, the fall of the dew condensation water from the through-hole 38 into the 1st and 2nd reagent containers 13 and 14 can be reduced, without making the reagent cover 34 thick.

  Note that the porous body may be formed on the inclined surface of the derivative made of a material such as resin, porous metal, or ceramic having the same shape as the derivatives 39 to 42.

  According to the first embodiment of the present invention described above, the dew condensation water generated in the through hole 35 is sucked into the first reagent by disposing the derivative 39 having the porous inclined surface 391 inscribed in the through hole 35. It can be dropped to the outer periphery of the openings 131, 141 of the first or second reagent container 13, 14 stopped below the position T1. In addition, by arranging the derivatives 40 to 42 that are inscribed in the through holes 36 to 38 and configured similarly to the derivative 39, the dew condensation water generated in the through holes 36 to 38 is removed from the first and second reagent suction positions T2, T2. It can be dropped to the outer periphery of the openings 131, 141 of the first or second reagent containers 13, 14 stopped at T4, T5.

  Thereby, the enlargement of the reagent storage 17 is prevented, and contamination or dilution of the first and second reagents due to the fall of condensed water into the first and second reagent containers 13 and 14 stored in the reagent storage 17 is reduced. can do.

  The present invention is not limited to the above embodiment, and a hydrophilic derivative having the same shape and size as the derivative 39 obtained by hydrophilic treatment of the surface layer of the inclined surface with, for example, a hydrophilic treatment agent is provided in each of the through holes 35 to 38. By inscribed, the outer periphery of the openings 131, 141 of the first or second reagent containers 13, 14 stopped at the first and second reagent suction positions T1, T2, T4, T5 along the hydrophilic inclined surface. It can be guided to the lower end located above and dropped from the lower end to the outer periphery of the opening 131 or the opening 141. Thereby, the contamination or dilution of the 1st and 2nd reagent by the fall of the dew condensation water in the 1st and 2nd reagent containers 13 and 14 accommodated in the reagent storage 17 can be reduced.

  Moreover, as shown in FIG. 8, you may implement so that the derivative | guide_body 39a may be arrange | positioned to each through-hole 35 thru | or 38. FIG. The derivative 39a has the same shape and size as the derivative 39, and a plurality of radial grooves 394 connecting the upper end and the lower end are formed on the inclined surface 391a. The lower end of the derivative 39a located above the outer peripheries of the openings 131, 141 of the first or second reagent containers 13, 14 stopped at the first and second reagent suction positions T1, T2, T4, T5 along the groove 394. It can guide to a part and it can be made to fall to the opening part 131 or the opening part 141 outer periphery from this lower end part. Thereby, the contamination or dilution of the 1st and 2nd reagent by the fall of the dew condensation water in the 1st and 2nd reagent containers 13 and 14 accommodated in the reagent storage 17 can be reduced.

  Hereinafter, Example 2 of the reagent storage in the automatic analyzer according to the present invention will be described with reference to FIGS. FIG. 9 is a diagram illustrating the configuration of the reagent storage according to the second embodiment. The difference between the second embodiment shown in FIG. 9 and the first embodiment in FIG. 3 is that the derivatives 39 to 42 of the reagent storage 17 in the first embodiment are replaced with derivatives having different shapes. In addition, among the units of the reagent storage constituting the second embodiment, the same reference numerals are given to the same units as the first embodiment, and the description will be simplified.

  In FIG. 9, the reagent store 17 b is a detachable cover that covers the reagent case 33 for storing the first and second reagent containers 13 and 14 in which the first and second reagents are stored, and the opening of the reagent case 33. A reagent cover 34, a cooler 43 that keeps the first and second reagent containers 13 and 14 stored in the reagent case 33, and derivatives 39 b to 42 b arranged in the reagent case 34 are provided. The reagent cover 34 has through holes 35 to 38, and the derivatives 39b to 42b are inscribed in the through holes 35 to 38.

  FIG. 10 is a diagram showing an example of the derivative 39b shown in FIG. This derivative 39b is made of a porous material similar to that of the derivative 39 in order to form a porous shape in the through hole 35, and has an opening that penetrates in the vertical direction. This opening part is comprised by the inclined surface 391b which comprises a part of conical side surface where a diameter increases, for example, as it approaches in the reagent storage 17b.

  At the lower end of the inclined surface 391b, two notches 395 are provided in the portion on the track of the openings 131, 141 of the first and second reagent containers 13, 14 held by the first reagent rack 15. Yes. Also, the first reagent container in which the dropping point 396, which is the two opposite lowest ends of the lower end portions of the inclined surface 391b provided with the notches 395, stops at, for example, the first reagent suction position T1 other than the orbit. 13 is provided on a straight line 132 passing through the center in the width direction.

  The opening 392b at the upper end of the derivative 39b is the stop accuracy of the first reagent dispensing probe 23 moved to the first reagent suction position T1 and the position of the reagent cover 34 when the reagent cover 34 is attached to the reagent case 33. Based on the accuracy, the first reagent dispensing probe 23 stopped at the first reagent aspirating position T1 in order to aspirate the first reagent has a diameter r2 that can enter the reagent container 17b without contacting the derivative 39b. Further, the distance between the dropping points 396 coincides with the diameter r3 of the opening 393 in the derivative 39 shown in FIG.

  In this way, by arranging the derivative 39b having the porous inclined surface 391b inscribed in the through-hole 35, the condensed water generated in the through-hole 35 is retained on the surface of the inclined surface 391b, and thus the inclined surface 391b. The surface can be hydrophilized. Then, the water droplet grown on the inclined surface 391b is guided to the dropping point 396 along the inclined surface 391b with its own weight and hydrophilized affinity, and stopped at the first reagent suction position T1 from the dropping point 396. The first or second reagent container 13, 14 can be dropped to a position in the longitudinal direction outside the openings 131, 141. In addition, the first reagent aspirating position T1 can be dropped to a position in the longitudinal direction outside the openings 131 and 141 in the rotating first or second reagent containers 13 and 14.

  Thus, without increasing the thickness of the reagent cover 34, the first and second reagents are prevented from falling due to the dew condensation water from the through hole 35 into the first and second reagent containers 13 and 14 held in the first reagent rack 15. Contamination or dilution can be prevented.

  The derivative 40b is configured in the same manner as the derivative 39b. At the lower end portion of the derivative 40b, 2 is provided at the part on the orbit of the openings 131 and 141 of the first and second reagent containers 13 and 14 held by the second reagent rack 16. There are two notches. Further, two opposing dropping points in the lower end of the inclined surface provided with the notch are provided on a straight line passing through the center in the width direction of the first reagent container 13 stopped at the first reagent suction position T2. ing.

  The derivative 41b is configured in the same manner as the derivative 39b, and the derivative 41b has a lower end portion of a portion of the opening 131, 141 of the first and second reagent containers 13 and 14 held in the first reagent rack 15 on the orbital portion. There are two notches. Further, two opposing dropping points in the lower end portion of the inclined surface provided with the notch are provided on a straight line passing through the center in the width direction of the second reagent container 14 stopped at the second reagent suction position T4, for example. It has been.

  The derivative 42b is configured in the same manner as the derivative 39b. At the lower end of the derivative 42b, 2 is provided in the portion on the orbit of the openings 131 and 141 of the first and second reagent containers 13 and 14 held by the second reagent rack 16. There are two notches. Further, two opposing dropping points in the lower end portion of the inclined surface provided with the notch are provided on a straight line passing through the center in the width direction of the second reagent container 14 stopped at the second reagent suction position T4. ing.

  Accordingly, the first and second reagent suction positions T2, T4, T5 can be dropped to positions in the longitudinal direction outside the openings 131, 141 in the first or second reagent containers 13, 14, and the reagent cover 34 Without increasing the thickness of the first and second reagents due to the fall of condensed water from the through holes 36 to 38 into the first and second reagent containers 13 and 14 held in the first and second reagent racks 15 and 16. Contamination or dilution can be prevented.

  According to the second embodiment of the present invention described above, the dew condensation water generated in the through hole 35 is removed from the first reagent rack 15 by disposing the derivative 39b having the porous inclined surface 391b inscribed in the through hole 35. Can be dropped out of the openings 131 and 141 of the first and second reagent containers 13 and 14 held in the container. Further, by arranging the derivatives 40b to 42b configured similarly to the derivative 39b inscribed in the through holes 36 to 38, the dew condensation water generated in the through holes 36 to 38 is supplied to the first and second reagent racks 15 and 16. The held first and second reagent containers 13, 14 can be dropped out of the openings 131, 141.

  This prevents the reagent storage 17b from becoming large and prevents contamination or dilution of the first and second reagents due to the condensation water falling into the first and second reagent containers 13 and 14 stored in the reagent storage 17b. can do.

  In addition, this invention is not limited to the said Example, For example, as shown in FIG. 11, you may implement so that the derivative | guide_body 39c seen from the bottom may be arrange | positioned in the through-hole 35. FIG. The derivative 39c has the same shape and size as the derivative 39b. The lower end portion of the inclined surface 391c on the inner peripheral side is close to one dropping point of two dropping points 396c corresponding to the dropping point 396 of the derivative 39b and one dropping point of the upper end portion of the inclined surface 391c. A plurality of grooves 394c are formed to connect a plurality of positions obtained by dividing one of the semicircles at a predetermined interval. In addition, a plurality of grooves 394c are formed to connect the other dropping point and a plurality of positions obtained by dividing the other semicircle on the side near the other dropping point of the upper end portion of the inclined surface 391c at a predetermined interval. The notch 395c at the lower end of the derivative 39c is disposed in the through hole 35 so as to be positioned on the track of the openings 131 and 141 of the first and second reagent containers 13 and 14 held in the first reagent rack 15. Is done.

  As a result, water droplets grown on the inclined surface 391c are guided along the groove 394c to the dropping point 396c, and the longitudinal length outside the openings 131, 141 in the first or second reagent container 13, 14 at the first reagent suction position T1. The dew condensation water generated in the through hole 35 can be dropped to a position in the direction, and the openings 131 and 141 of the first and second reagent containers 13 and 14 held in the first and second reagent racks 15 and 16. Can be dropped outside.

  In addition, each of the derivatives configured in the same manner as the derivative 39b has openings in the first and second reagent containers 13 and 14 in which a notch at the lower end of the derivative is held in the first or second reagent racks 15 and 16. It arrange | positions in each through-hole 36 thru | or 38 so that it may be located on the track | orbit of 131,141. Thereby, the dew condensation water generated in the through holes 36 to 38 is dropped outside the openings 131 and 141 of the first and second reagent containers 13 and 14 held in the first and second reagent racks 15 and 16. it can.

T1, T2 First reagent aspirating position T4, T5 Second reagent aspirating position 13 First reagent container 14 Second reagent container 17 Reagent storage 23 First reagent dispensing probe 27 Second reagent dispensing probe 33 Reagent case 34 Reagent cover 35 , 36, 37, 38 Through holes 39, 40, 41, 42 Derivatives 131, 141 Opening 391 Inclined surface 392, 393 Opening

Claims (6)

In an automatic analyzer for dispensing a sample and a reagent contained in a reagent container having an opening into a reaction container and measuring the mixed solution,
With a reagent case for housing the pre-Symbol reagent container, and a reagent cover for reagent dispensing probe have a through hole that enters, to cover the reagent case to suck the reagent from the reagent container A reagent storage ,
A porous derivative that is inscribed in the through hole, guides dew condensation water generated in the through hole, and drops it outside the opening of the reagent container housed in the reagent storage ;
Have
The derivative has an opening therethrough;
The opening of the derivative is constituted by an inclined surface that forms part of a conical side surface whose diameter increases as it approaches the inside of the reagent storage,
The automatic analyzer according to claim 1, wherein the diameter of the opening at the lower end of the derivative is longer than the diameter of the opening of the reagent container . In an automatic analyzer for dispensing a sample and a reagent contained in a reagent container having an opening into a reaction container and measuring the mixed solution,
And reagent case for accommodating the previous Symbol reagent container,
A reagent storage having a reagent cover for reagent dispensing probe have a through hole that enters, to cover the reagent case to suck the reagent from the reagent container,
A hydrophilic derivative that is inscribed in the through hole, guides dew condensation water generated in the through hole, and drops it outside the opening of the reagent container housed in the reagent storage ;
Have
The derivative has an opening therethrough;
The opening of the derivative is constituted by an inclined surface that forms part of a conical side surface whose diameter increases as it approaches the inside of the reagent storage,
The automatic analyzer according to claim 1, wherein the diameter of the opening at the lower end of the derivative is longer than the diameter of the opening of the reagent container . A reagent rack disposed in the reagent storage and movably holding the reagent container;
The notch is provided in the lower end part of the said inclined surface in the part on the track | orbit of the opening part of the said reagent container hold | maintained at the said reagent rack, The Claim 1 or Claim 2 characterized by the above-mentioned. Automatic analyzer. In an automatic analyzer for dispensing a sample and a reagent contained in a reagent container having an opening into a reaction container and measuring the mixed solution,
And reagent case for accommodating the previous Symbol reagent container,
A reagent storage having a reagent cover for reagent dispensing probe have a through hole that enters, to cover the reagent case to suck the reagent from the reagent container,
A derivative that is inscribed in the through-hole and that has a groove formed to allow the condensed water generated in the through-hole to be dropped outside the opening of the reagent container housed in the reagent storage ;
I have a,
The derivative has an opening therethrough;
The opening of the derivative is constituted by an inclined surface in which a plurality of grooves connecting the upper end and the lower end forming a part of a conical side surface whose diameter increases as it approaches the inside of the reagent container,
The automatic analyzer according to claim 1, wherein the diameter of the opening at the lower end of the derivative is longer than the diameter of the opening of the reagent container . A reagent rack disposed in the reagent storage and movably holding the reagent container;
The inclined surface is provided with a notch in a portion of the opening of the reagent container held in the reagent rack at the lower end portion on the track, and the lowermost end portion of the lower end portion provided with the notch. The automatic analyzer according to claim 4 , wherein a plurality of the grooves connecting the upper end portion and the upper end portion are formed. The automatic analyzer according to any one of claims 1 to 5 , wherein the diameter of the opening at the upper end of the derivative is shorter than the diameter of the opening of the reagent container.

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