JP5258653B2 - Food for colonoscopy - Google Patents
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Description
本発明は、大腸内視鏡検査において、大腸内粘膜を観察する際の内視鏡の視界の悪さを改善できる大腸内視鏡検査用食品に関する。 The present invention relates to a food for colonoscopy that can improve the poor visibility of the endoscope when observing the mucosa in the large intestine in colonoscopy.
近年食生活の欧米化に伴い、大腸癌、ポリープ、大腸炎などの大腸疾患の発生頻度が増加している。特に悪性腫瘍について、女性の死亡率を部位別に見ると「大腸」は上昇傾向が続き、平成１５年には「胃」を上回って第１位となり、その早期発見および早期治療の必要性が叫ばれている。従来、大腸検査といえばバリウムを使用した注腸検査法が主体であったが、最近では的確な診断と治療が行なうことのできる大腸内視鏡検査法が主体である。 In recent years, with the Westernization of dietary habits, the incidence of colon diseases such as colon cancer, polyps, and colitis is increasing. In particular, regarding malignant tumors, when looking at the mortality rate of women by region, the “large intestine” continued to rise, surpassing the “stomach” in 2003, and ranked first, and the need for early detection and treatment was screaming. It has been released. Conventionally, colon examination has been mainly an enema examination method using barium, but recently, an colon examination method which can perform an accurate diagnosis and treatment is mainly.
大腸内視鏡検査法は、検査当日に経口腸管洗浄剤を約２〜４Ｌ飲用することで、大腸の中を完全に空にし、肛門から内視鏡を挿入して大腸内の様子を直接観察することにより病変を検査する方法である。正確な検査を行なうためには、検査時の腸内残渣が少ないことが求められる。そのため、前日の食事は食物繊維が多い野菜の摂取を控えたり、病院から指示された低繊維、低脂肪の味気ない検査食を摂取する等の制限がある。 In colonoscopy, about 2 to 4 L of oral intestinal cleanser is drunk on the day of the examination, so that the inside of the large intestine is completely emptied and the endoscope is inserted through the anus to directly observe the state inside the large intestine. This is a method for inspecting lesions. In order to perform an accurate test, it is required that there are few intestinal residues at the time of the test. Therefore, the meal of the previous day has restrictions such as refraining from taking vegetables with high dietary fiber, or taking low-fiber, low-fat test foods ordered by the hospital.
しかしながら、大腸内視鏡検査法には、検査の前処置である腸管内容物を排除するための大量の経口腸管洗浄剤の服用が必要であり、肉体的な負担がかかるという問題があった。 However, the large intestine endoscopy requires the administration of a large amount of oral intestinal cleanser for eliminating the contents of the intestinal tract, which is a pretreatment of the examination, and there is a problem that a physical burden is applied.
上記大量の経口腸管洗浄剤の服用による負担を軽減させるため、特定量以下の不溶性食物繊維および特定量以上の脂質と、一定の大きさ以上の具材とを組み合わせることで、服用する経口腸管洗浄剤の量を１Ｌに減じることが出来、且つ美味しい大腸内視鏡検査用の検査食が提案されている（特許文献１）また、味気なく、満腹感の得られない検査食の摂取を解決するため、果実由来酵素、特にパパイヤ末を配合した大腸検査食が提案されている（特許文献２）。 In order to reduce the burden of taking a large amount of the above-mentioned oral intestinal cleansing agent, oral intestinal cleaning to be taken by combining insoluble dietary fiber below a specific amount and lipid above a specific amount with ingredients over a certain size The amount of the medicine can be reduced to 1L, and a delicious test food for large intestine endoscopy has been proposed (Patent Document 1). In addition, the ingestion of the test food that is unsatisfactory and does not provide a feeling of fullness is solved. Therefore, a large intestine inspection food containing fruit-derived enzymes, particularly papaya powder, has been proposed (Patent Document 2).
しかしながら、服用する経口腸管洗浄剤の量を１Ｌに減じ、前記のような検査食を摂取しても、大腸内粘膜を観察する際の内視鏡の視界の悪さを充分改善することはできなかった。 However, even if the amount of the oral intestinal cleaning agent to be taken is reduced to 1 L and the above-described test meal is taken, the poor visibility of the endoscope when observing the mucosa in the large intestine cannot be sufficiently improved. It was.
本発明の目的は、大腸内視鏡検査において、大腸内粘膜を観察する際の内視鏡の視界の悪さを改善できる大腸内視鏡検査用食品を提供するものである。 An object of the present invention is to provide a food for colonoscopy that can improve the poor visibility of the endoscope when observing the mucosa in the large intestine in colonoscopy.
本発明者は、上記目的を達成すべく大腸内視鏡検査用食品に用いる種々の原料について鋭意研究を重ねた結果、１〜２７ｃｍ３ のニンジンを含有し、特定量の水溶性食物繊維とソルビトールを含有させるならば、意外にも大腸内視鏡検査において、大腸内粘膜を観察する際の内視鏡の視界の悪さを改善できることを見出し、本発明を完成するに至った。 The present inventor has conducted extensive studies on various raw materials used in colonoscopy for food to achieve the above object, containing two engines of 1～27Cm 3, and a specific amount of soluble fiber Surprisingly, it has been found that if sorbitol is contained, the poor visibility of the endoscope when observing the mucosa in the large intestine can be improved in the colonoscopy, and the present invention has been completed.
すなわち、本発明は、
（１）１〜２７ｃｍ３ のニンジンを含有し、水溶性食物繊維の含有量が１食当り０．５〜２．５ｇであって、更にソルビトールを含有する大腸内視鏡検査用食品、
（２）１〜２７ｃｍ ３ のジャガイモを含有する、（１）の大腸内視鏡検査用食品、
（３）３〜１０糖類のマルトオリゴ糖を含有する（１）又は（２）の大腸内視鏡検査用食品、
（４）３〜１０糖類のマルトオリゴ糖が、３〜５糖類を糖組成の６０％以上占めるものである（３）の大腸内視鏡検査用食品、
である。
That is, the present invention
(1) containing two engine of 1～27Cm 3, with the content of the water-soluble dietary fiber a per meal 0.5 to 2.5 g, colonoscopy food further contains sorbitol,
(2) The food for colonoscopy according to (1), comprising 1 to 27 cm 3 of potato,
(3) Food for colonoscopy of (1) or (2) containing 3 to 10 saccharide maltooligosaccharides,
(4) Food for colonoscopy according to (3) , wherein 3 to 10 saccharide maltooligosaccharides occupy 3 to 5 saccharides by 60% or more of the sugar composition,
It is.
本発明によれば、大腸内視鏡検査において、大腸内粘膜を観察する際の内視鏡の視界の悪さを改善できる大腸内視鏡検査用食品を提供することができる。これにより、更なる大腸疾患の予防または早期治療が期待できる。 ADVANTAGE OF THE INVENTION According to this invention, the foodstuff for colonoscopy which can improve the bad visibility of an endoscope at the time of observing a colonic mucosa in colonoscopy can be provided. As a result, further prevention or early treatment of colorectal diseases can be expected.
以下、本発明を詳細に説明する。なお、本発明において「％」は「質量％」を意味する。 Hereinafter, the present invention will be described in detail. In the present invention, “%” means “mass%”.
本発明の大腸内視鏡検査用食品は、１〜２７ｃｍ３のジャガイモおよび／またはニンジンを含有し、水溶性食物繊維の含有量が１食当り０．５〜２．５ｇであって、更にソルビトールを含有することを特徴とし、これにより、大腸内視鏡検査において、大腸内粘膜を観察する際の内視鏡の視界の悪さを改善することができる。 The food for colonoscopy of the present invention contains 1-27 cm 3 of potato and / or carrot, the content of water-soluble dietary fiber is 0.5-2.5 g per meal, and further sorbitol This makes it possible to improve the poor visibility of the endoscope when observing the mucosa in the large intestine in colonoscopy.
本発明の大腸内視鏡検査用食品は、肛門から内視鏡を挿入し大腸内粘膜の様子を観察する大腸内視鏡検査において、検査前日に被験者が摂取し、検査時の腸内残渣が低減されるよう設計された大腸内視鏡検査専用の食品である。 The food for colonoscopy of the present invention is a colonoscopy in which the endoscope is inserted from the anus and the state of the mucosa in the large intestine is observed. A food designed specifically for colonoscopy that is designed to be reduced.
本発明の大腸内視鏡検査用食品の種類としては、本発明の効果を損なわない範囲であれば、いずれでもよく例えば、和食、中華食、洋食等が挙げられる。具体的な料理としては、シチュー、カレーのような煮込み食品類、筑前煮、肉じゃが、そぼろ煮のような煮物類、ポトフ、豚汁、味噌汁のようなスープ類、ポテトサラダ、マカロニサラダのようなサラダ類などが挙げられる。 Any kind of food for colonoscopy of the present invention may be used as long as it does not impair the effects of the present invention, and examples thereof include Japanese food, Chinese food, and Western food. Specific dishes include stewed foods such as stew and curry, boiled dishes such as Chikuzen boiled, meat potatoes, boiled soboboil, soups such as potov, pork soup, miso soup, salads such as potato salad and macaroni salad And the like.
本発明の大腸内視鏡検査用食品に用いる具材は、大腸内粘膜を観察する際の内視鏡の視界の悪さを改善する観点から、ジャガイモおよび／またはニンジンを用いる。 The ingredients used for the food for colonoscopy of the present invention use potato and / or carrot from the viewpoint of improving the poor visibility of the endoscope when observing the mucosa in the large intestine.
また、本発明の大腸内視鏡検査用食品は、食事として満足感を得る観点から、１〜２７ｃｍ３、好ましくは２〜２０ｃｍ３のジャガイモおよび／またはニンジンを含有する。 Moreover, the foodstuff for colonoscopy of this invention contains 1-27 cm < 3 >, Preferably 2-20 cm < 3 > potato and / or a carrot from a viewpoint of obtaining satisfaction as a meal.
本発明の大腸内視鏡検査用食品に用いるジャガイモは、その種類を特に限定するものではないが、例えば、男爵芋、メークイン、キタアカリ、とうや、トヨシロ、ワセシロ、インカのめざめ、デジマ、ラセット・バーバング、シンシア、ホッカイコガネ、農林１号、紅丸、マルチダなどを用いるとよい。 The type of potato used in the food for colonoscopy of the present invention is not particularly limited, but for example, Baron 芋, Makein, Kita Akari, Toya, Toyoshiro, Waseshiro, Inca Ame, Digima, Lasset Barbang Cynthia, beetle, Agricultural forest No. 1, Benimaru, Maruta, etc. may be used.
また、本発明の大腸内視鏡検査用食品に用いるニンジンは、その種類を特に限定するものではないが、例えば、西洋系ニンジン、東洋系ニンジンに加え、根の長さによって分類される三寸ニンジン、四寸ニンジン、五寸ニンジンなどの短根種と長根種の他、ミニニンジン、スイートキャロット、ピッコロ、ベビーキャロットなどを用いるとよい。 In addition, the carrot used in the food for colonoscopy of the present invention is not particularly limited in its type. For example, in addition to western carrots, oriental carrots, three sizes classified by root length. In addition to short and long root species such as carrots, 4 inch carrots, and 5 inch carrots, mini carrots, sweet carrots, piccolo, baby carrots and the like may be used.
本発明の大腸内視鏡検査用食品において、ジャガイモおよび／またはニンジンの含有量は、食事として満足感を得る観点から、１食当り３０〜９０ｇが好ましく、４０〜８０ｇがより好ましい。 In the food for colonoscopy of the present invention, the content of potatoes and / or carrots is preferably 30 to 90 g, more preferably 40 to 80 g, from the viewpoint of obtaining satisfaction as a meal.
本発明の大腸内視鏡検査用食品は、水溶性食物繊維の含有量を規定している。ここで、水溶性食物繊維とは、学術上ヒトの消化酵素で消化（分解）されない食品成分である食物繊維のうち、水に溶ける性質を有するものをいう。 The food for colonoscopy of the present invention defines the content of water-soluble dietary fiber. Here, water-soluble dietary fiber refers to a dietary fiber that is soluble in water among dietary fibers that are food components that are not digested (degraded) by human digestive enzymes.
また、水溶性食物繊維の含有量は、五訂日本食品標準成分表に記載されたプロスキー変法（酵素−重量法）またはＨＰＬＣ法を組み合わせた方法によって測定する。 Moreover, content of water-soluble dietary fiber is measured by the method combining the Prosky modified method (enzyme-gravimetric method) or HPLC method described in the 5th Japanese food standard ingredient table | surface.
本発明の大腸内視鏡検査用食品における水溶性食物繊維の含有量は、１食当り０．５〜２．５ｇであり、０．８〜２ｇが好ましい。水溶性食物繊維の含有量が前記範囲より少ないと、大腸内粘膜を観察する際の内視鏡の視界の悪さを改善できない場合が有り、前記範囲より多いと、内視鏡検査時の腸内に残渣が残り、検査し難い場合がある為である。 The content of water-soluble dietary fiber in the food for colonoscopy of the present invention is 0.5 to 2.5 g per serving, and preferably 0.8 to 2 g. If the content of water-soluble dietary fiber is less than the above range, the poor visibility of the endoscope when observing the mucosa in the large intestine may not be improved. This is because there are cases where residue remains on the surface and it is difficult to inspect.
本発明の大腸内視鏡検査用食品は、大腸内粘膜を観察する際の内視鏡の視界の悪さを改善する観点から、ソルビトールを用いる。本発明で用いるソルビトールは、糖類が持つカルボニル基を還元して得られる鎖状多価アルコールである糖アルコールの一種であり、グルコースのカルボニル基を還元して得られる糖アルコールで、Ｄ−ソルビトールをいう。また、本発明で用いるソルビトールの形態としては、日本薬局方、日本食品添加物規格などの規格に適したものであればよい。 The food for colonoscopy of the present invention uses sorbitol from the viewpoint of improving the poor visibility of the endoscope when observing the mucosa in the large intestine. The sorbitol used in the present invention is a kind of sugar alcohol that is a chain polyhydric alcohol obtained by reducing the carbonyl group of a saccharide, and is a sugar alcohol obtained by reducing the carbonyl group of glucose. Say. Moreover, as a form of sorbitol used by this invention, what is necessary is just the thing suitable for standards, such as a Japanese pharmacopoeia and a Japanese food additive specification.
本発明の大腸内視鏡検査用食品に用いるソルビトールの含有量は、１食当り０．５〜１５ｇが好ましく、１．５〜８ｇがより好ましい。ソルビトールの含有量が前記範囲より少ないと、大腸内粘膜を観察する際の内視鏡の視界の悪さが改善され難い場合があり、また、前記範囲より多いと、下痢を引き起こす場合があり、好ましくない。 The content of sorbitol used in the food for colonoscopy of the present invention is preferably 0.5 to 15 g, more preferably 1.5 to 8 g per serving. If the content of sorbitol is less than the above range, it may be difficult to improve the poor visibility of the endoscope when observing the mucosa in the large intestine, and if it is more than the above range, it may cause diarrhea, preferably Absent.
本発明の大腸内視鏡検査用食品は、３〜１０糖類のマルトオリゴ糖を含有すると、更なる大腸内視鏡検査における大腸内粘膜を観察する際の内視鏡の視界の悪さが改善される為、好ましい。 When the food for colonoscopy of the present invention contains a malto-oligosaccharide of 3 to 10 sugars, the poor visibility of the endoscope when observing the mucosa in the large intestine in further colonoscopy is improved. Therefore, it is preferable.
本発明の大腸内視鏡検査用食品に用いるマルトオリゴ糖は、グルコースを単位として３〜１０分子がα‐１、４グルコシド結合した糖類である。また、このようなマルトオリゴ糖は、グルコースの結合数により、例えば、３個結合した３糖類はマルトトリオース、４個結合した４糖類はマルトテトラオース、５糖類はマルトペンタオース等と称される。 The maltooligosaccharide used in the food for colonoscopy of the present invention is a saccharide in which 3 to 10 molecules are α-1,4 glucoside-bonded with glucose as a unit. In addition, such malto-oligosaccharides are referred to as the number of glucose bonds, for example, 3 linked trisaccharides are called maltotriose, 4 linked 4 saccharides are maltotetraose, 5 sugars are called maltopentaose, etc. .
また、前述のような各結合数の糖類を高純度に精製したものばかりでなく、３〜１０糖類の混合物を主成分としたマルトオリゴ糖を用いてもよい。また、マルトオリゴ糖の形態も、市販されているものであれば、特に限定するものではないが、液状、シロップ状、粉末状、顆粒状、スラリー状のものなどを用いることができる。 Moreover, not only what refine | purified the saccharide | sugar of each bond number as mentioned above but high purity, you may use the maltooligosaccharide which has the mixture of 3-10 saccharides as a main component. In addition, the form of maltooligosaccharide is not particularly limited as long as it is commercially available, and liquid, syrup, powder, granule, slurry and the like can be used.
本発明の大腸内視鏡検査用食品に用いる３〜１０糖類のマルトオリゴ糖は、大腸内粘膜を観察する際の内視鏡の視界の悪さを改善する観点から、３〜５糖類が糖組成の６０％以上を占めるマルトオリゴ糖が好ましく、３〜４糖類が糖組成の６０％以上を占めるマルトオリゴ糖がより好ましい。 The 3-10 saccharide maltooligosaccharide used in the food for colonoscopy of the present invention is composed of 3-5 saccharides having a sugar composition from the viewpoint of improving the poor visibility of the endoscope when observing the mucosa in the large intestine. A maltooligosaccharide occupying 60% or more is preferable, and a maltooligosaccharide having 3 to 4 saccharides occupying 60% or more of the sugar composition is more preferable.
本発明の大腸内視鏡検査用食品に用いる３〜１０糖類のマルトオリゴ糖の含有量は、大腸内粘膜を観察する際の内視鏡の視界の悪さを改善する観点から、１食当り０．１〜１０ｇが好ましく、２〜９ｇがより好ましい。 The content of malto-oligosaccharides of 3 to 10 saccharides used in the food for colonoscopy of the present invention is 0. 0 per serving from the viewpoint of improving the poor visibility of the endoscope when observing the mucosa in the colon. 1-10g is preferable and 2-9g is more preferable.
本発明の大腸内視鏡検査用食品の１食とは、料理１品を１食とするものだけでなく、料理２品以上を組み合わせて１食とするものも含む。例えば、ビーフシチューとクラッカー、煮物とおかゆなどのように２品以上の料理を組み合わせて１食とすることができる。なお、料理を２品以上組み合わせた場合、ジャガイモおよび／またはニンジン、水溶性食物繊維、ソルビトール、３〜１０糖類のマルトオリゴ糖のそれぞれの１食当りの含有量は、１食として摂取した２品以上の料理に含まれる合計量のことをいう。 One meal of the food for colonoscopy of the present invention includes not only one meal for one dish but also one that combines two or more dishes for one meal. For example, a combination of two or more dishes such as beef stew and crackers, boiled food and porridge can be combined into one meal. In addition, when two or more dishes are combined, the content of each potato and / or carrot, water-soluble dietary fiber, sorbitol, and 3-10 saccharide maltooligosaccharide is 2 or more ingested as one meal. Means the total amount contained in the dish.
本発明の大腸内視鏡検査用食品には上記１〜２７ｃｍ３のジャガイモおよび／またはニンジン、ソルビトールおよび３〜１０糖類のマルトオリゴ糖以外に、本発明の効果を損なわない範囲で該当食品に一般的に使用されている各種原料を適宜選択し配合させることができる。例えば、グルタミン酸ナトリウム、食塩、砂糖、醤油、味噌、みりん、酒、酢などの各種調味料、各種エキス、菜種油、コーン油、ゴマ油、大豆油、パーム油などの動植物油、カツオ、昆布、煮干の出汁、中華風出汁、コンソメ、ブイヨンなどの西洋風出汁、色素、生姜、わさび、大蒜などの薬味などが挙げられる。具材としては、例えば、大根、タマネギ、アスパラガス、おくら、かぶ、かぼちゃ、きゃべつ、トマト、なす、ブロッコリー、ほうれん草、レタスなどを用いることができる。 Potatoes, and / or carrots in colonoscopy for food of the present invention is the 1～27Cm 3, in addition to maltooligosaccharides of sorbitol and 3-10 saccharides, generally applicable food does not impair the effects of the present invention Various raw materials used in the above can be appropriately selected and blended. For example, various seasonings such as sodium glutamate, salt, sugar, soy sauce, miso, mirin, sake, vinegar, various extracts, rapeseed oil, corn oil, sesame oil, soybean oil, palm oil and other animal and vegetable oils, bonito, kelp, boiled Examples include broth, Chinese-style broth, Western-style broth such as consomme, bouillon, and condiments such as pigments, ginger, wasabi and daikon. As ingredients, for example, radish, onion, asparagus, potter, turnip, pumpkin, cabbage, tomato, eggplant, broccoli, spinach, lettuce and the like can be used.
また、本発明の大腸内視鏡検査用食品の製造方法は、上述の１〜２７ｃｍ３のジャガイモおよび／またはニンジン、ソルビトールを配合させる以外は常法に則り製造すれば良いが、例えば、ビーフシチューは以下のように製造することができる。まず、ソルビトールを配合した調味液を調製し、必要であればボイルなどの前処理を施したジャガイモおよび／またはニンジンなどの具材と調製した調味液とをレトルトパウチに充填し、レトルト処理（１００〜１３０℃、４〜９０分程度）を施すなどの方法が挙げられる。 Further, the method for producing a food for colonoscopy of the present invention may be produced in accordance with a conventional method except that the above-mentioned 1 to 27 cm 3 of potato and / or carrot and sorbitol are blended. For example, beef stew Can be produced as follows. First, a seasoning liquid containing sorbitol is prepared. If necessary, ingredients such as boiled potato and / or carrot and the prepared seasoning liquid are filled in a retort pouch, and a retort treatment (100 ~ 130 ° C, about 4 to 90 minutes).
以下に本発明の大腸内視鏡検査用食品を実施例および比較例に基づき詳述する。なお、本発明はこれに限定するものではない。 Hereinafter, the food for colonoscopy of the present invention will be described in detail based on Examples and Comparative Examples. Note that the present invention is not limited to this.
〔実施例１〕
（１）大腸内視鏡検査用食品（レトルトビーフシチュー）の調製
下記の配合表に従って、二重釜にデミグラスソース、タマネギペースト、ブイヨン、マルトオリゴ糖（３〜５糖類が糖組成の６０％以上を占め、且つ３〜４糖類が糖組成の６０％以上を占めるもの）、トマトペースト、ソルビトール、サラダ油、小麦粉、上白糖、清水を投入し、加熱攪拌した。９０℃達温後加熱を停止し、ビーフシチューの調味液１２０ｇを製した。次に、２００ｇ容のレトルトパウチに製した調味液１２０ｇ、牛肉（ボイル済）２０ｇ、約３．９ｃｍ３にカットしたジャガイモ２０ｇおよびニンジン４０ｇを充填し、開口部をシールした。シール後、レトルト処理（１２０℃、２０分）を施し、本発明の大腸内視鏡検査用食品を得た。
この製した大腸内視鏡検査用食品は１〜２７ｃｍ３のジャガイモおよびニンジンを含有し、１食当り水溶性食物繊維を１．６ｇ、ソルビトールを３ｇ、３〜１０糖類のマルトオリゴ糖を５ｇ含有するものであった。
[Example 1]
(1) Preparation of colonoscopy food (retort beef stew) According to the following recipe, demiglace sauce, onion paste, bouillon, maltooligosaccharide (3-5 saccharides occupy more than 60% of the sugar composition) In addition, tomato paste, sorbitol, salad oil, wheat flour, sucrose, and fresh water were added, and the mixture was heated and stirred. After reaching 90 ° C., the heating was stopped to prepare 120 g of beef stew seasoning liquid. Next, 120 g of seasoning liquid produced in a 200 g retort pouch, 20 g of beef (boiled), 20 g of potato cut to about 3.9 cm 3 and 40 g of carrots were filled, and the opening was sealed. After sealing, retort treatment (120 ° C., 20 minutes) was performed to obtain a food for colonoscopy of the present invention.
This prepared food for colonoscopy contains 1-27 cm 3 of potato and carrot, and contains 1.6 g of water-soluble dietary fiber, 3 g of sorbitol, 5 g of malto-oligosaccharide of 3-10 sugars per serving. It was a thing.
＜大腸内視鏡検査用食品（レトルトビーフシチュー）＞
（具材）
ニンジン ４０ｇ
ジャガイモ ２０ｇ
牛肉（ボイル済） ２０ｇ
（調味液）
デミグラスソース ３７ｇ
タマネギペースト １５ｇ
トマトペースト １５ｇ
ブイヨン １３ｇ
マルトオリゴ糖（３〜５糖類が糖組成の６０％以上を占め、
且つ３〜４糖類が糖組成の６０％以上を占めるもの） ５ｇ
小麦粉 ４ｇ
ソルビトール ３ｇ
サラダ油 ３ｇ
上白糖 ０．６ｇ
清水 残余
―――――――――――――――――――――――――――――――――
合計 ２００ｇ
<Food for colonoscopy (retort beef stew)>
(Ingredients)
Carrot 40g
Potato 20g
Beef (boiled) 20g
(Seasoning liquid)
Demigrass sauce 37g
Onion paste 15g
Tomato paste 15g
Bouillon 13g
Maltooligosaccharides (3-5 saccharides account for over 60% of the sugar composition,
3-4 saccharides account for 60% or more of the sugar composition) 5g
4g flour
Sorbitol 3g
3g salad oil
0.6g white sugar
Shimizu Residues ――――――――――――――――――――――――――――――――――
Total 200g
（２）大腸内視鏡検査用食品の摂食方法（検査前日）
被験者に大腸内視鏡検査の前日の夕食として、２０時までに、実施例１（１）で調製したビーフシチューを摂取させ、就寝前に大腸刺激性下剤として、センノシド製剤（商品名「アローゼン」、（株）ポーラファルマ製）２包をコップ２〜３杯の水で服用させた。
(2) Food intake method for colonoscopy (the day before the test)
As a dinner on the day before colonoscopy, subjects were allowed to ingest the beef stew prepared in Example 1 (1) by 20:00, and a sennoside preparation (trade name “Arosen”) as a colonic stimulant laxative before bedtime. 2 bags (made by Pola Pharma Co., Ltd.) were taken with 2-3 cups of water.
（３）大腸内視鏡検査（検査当日）
検査当日は、検査が済むまで、食事を摂取しないようにし、検査開始の２、３時間前から、経口腸管洗浄剤（商品名「ニフレック、味の素ファルマ（株）製」）を２Ｌの水に溶解した溶解液を時速１Ｌで約１Ｌ服用し、便が透明になったところで、服用を終了した。その後、専門医により大腸内視鏡による検査を行なった。
(3) Colonoscopy (on the day of the examination)
On the day of the test, do not take any food until the test is completed, and dissolve the oral intestinal cleanser (trade name “NIFREC, manufactured by Ajinomoto Pharma Co., Ltd.”) in 2 L of water a few hours before the start of the test. The dissolved solution was taken at about 1 L per hour, and when the stool became transparent, the administration was terminated. Thereafter, an examination by a colonoscopy was performed by a specialist.
（４）結果
検査を行なったところ、大腸内粘膜を観察する際の内視鏡の視界の悪さは充分に改善されていた。
(4) Upon examination of the results, the poor visibility of the endoscope when observing the mucosa in the large intestine was sufficiently improved.
〔実施例２〕
実施例１（１）において、マルトオリゴ糖、ソルビトール、上白糖の配合量をそれぞれ０ｇ、１ｇ、２．８ｇに変更した以外は、実施例１（１）の方法に準じ、大腸内視鏡検査用食品を製した。この製した大腸内視鏡検査用食品は１〜２７ｃｍ３のジャガイモおよびニンジンを含有し、１食当り水溶性食物繊維を１．６ｇ、ソルビトールを１ｇ含有するものであった。
[Example 2]
For colonoscopy according to the method of Example 1 (1), except that the blending amounts of maltooligosaccharide, sorbitol, and super white sugar were changed to 0 g, 1 g, and 2.8 g, respectively, in Example 1 (1). Made food. The prepared food for colonoscopy contained 1-27 cm 3 of potato and carrot, and contained 1.6 g of water-soluble dietary fiber and 1 g of sorbitol per serving.
実施例１（２）および（３）に準じて、実施例２で製した大腸内視鏡検査食を摂取し、検査を行なったところ、大腸内粘膜を観察する際の内視鏡の視界の悪さは、検査に支障がない程度に改善されていた。 According to Example 1 (2) and (3), the colonoscopy food prepared in Example 2 was ingested and examined, and the scope of the endoscope when observing the mucosa in the colon was observed. The badness was improved to the extent that there was no problem with the examination.
〔実施例３〕
実施例１（１）において、マルトオリゴ糖（３〜５糖類が糖組成の６０％以上を占め、且つ３〜４糖類が糖組成の６０％以上を占めるもの）をマルトオリゴ糖（３〜１０糖類のマルトオリゴ糖を含有し、且つ３〜５糖類が糖組成の６０％未満であるもの）に置き換え、ジャガイモ、ニンジンおよびトマトペーストの配合量をそれぞれ６０ｇ、０ｇ、８ｇに変更した以外は、実施例１（１）の方法に準じ、大腸内視鏡検査用食品を製した。この製した大腸内視鏡検査用食品は、１〜２７ｃｍ３のジャガイモおよびニンジンを含有し、1食当り水溶性食物繊維を０．７ｇ、ソルビトールを３ｇ、３〜１０糖類のマルトオリゴ糖を５ｇ含有するものであった。
Example 3
In Example 1 (1), maltooligosaccharides (3-5 saccharides accounted for 60% or more of the saccharide composition and 3-4 saccharides accounted for 60% or more of the saccharide composition) were converted to maltooligosaccharides (of 3-10 saccharides). Example 1 except that malto-oligosaccharide was contained and 3-5 saccharides were less than 60% of the sugar composition, and the amounts of potato, carrot and tomato paste were changed to 60 g, 0 g and 8 g, respectively. According to the method of (1), a food for colonoscopy was prepared. This prepared food for colonoscopy contains 1-27 cm 3 of potato and carrot, contains 0.7 g of water-soluble dietary fiber, 3 g of sorbitol, 5 g of malto-oligosaccharide of 3-10 sugars. It was something to do.
実施例１（２）および（３）に準じて、実施例３で製した大腸内視鏡検査用食品を摂取し、検査を行なったところ、大腸内粘膜を観察する際の内視鏡の視界の悪さは改善されていた。 According to Example 1 (2) and (3), the food for large intestine endoscopy produced in Example 3 was ingested and examined. The field of view of the endoscope when observing the mucosa in the large intestine The badness of was improved.
〔比較例１〕
実施例１（１）において、約３．９ｃｍ３の大きさのジャガイモ２０ｇ、ニンジン４０ｇを約３．９ｃｍ３の大きさの大根６０ｇに置き換えた以外は、実施例１（１）の方法に準じ、大腸内視鏡検査用食品を製した。この製した大腸内視鏡検査用食品は１〜２７ｃｍ３の大根を含有し、１食当りの水溶性食物繊維を１．５２ｇ、ソルビトールを３ｇ、３〜１０糖類のマルトオリゴ糖を５ｇ含有するものであった。
[Comparative Example 1]
In Example 1 (1), potato 20g of a size of about 3.9 cm 3, but replacing the radish 60g of the size of the carrot 40g about 3.9 cm 3, according to the method of Example 1 (1) The food for colonoscopy was made. This prepared food for colonoscopy contains 1-27 cm 3 radish, contains 1.52 g of water-soluble dietary fiber per serving, 3 g of sorbitol, 5 g of malto-oligosaccharide of 3-10 sugars Met.
実施例１（２）および（３）に準じて、比較例１で製した大腸内視鏡検査用食品を摂取し、検査を行なったところ、大腸内粘膜を観察する際の内視鏡の視界の悪さは改善されておらず、検査に支障をきたした。 According to Example 1 (2) and (3), the food for large intestine endoscopy produced in Comparative Example 1 was ingested and examined. The field of view of the endoscope when observing the mucosa in the large intestine The badness of the test has not been improved, which has hindered the examination.
〔比較例２〕
実施例１（１）において、ソルビトール３ｇをマルチトール３ｇに置き換えた以外は、実施例１（１）の方法に準じ、大腸内視鏡検査用食品を製した。この製した大腸内視鏡検査用食品は１〜２７ｃｍ３のジャガイモおよびニンジンを含有し、１食当りの水溶性食物繊維を１．６ｇ、マルチトールを３ｇ、３〜１０糖類のマルトオリゴ糖を５ｇ含有するものであった。
[Comparative Example 2]
A food for colonoscopy was prepared according to the method of Example 1 (1) except that 3 g of sorbitol was replaced with 3 g of maltitol in Example 1 (1). The prepared food for colonoscopy contains 1-27 cm 3 of potato and carrot, 1.6 g of water-soluble dietary fiber per serving, 3 g of maltitol, 5 g of malto-oligosaccharide of 3-10 sugars. Contained.
実施例１（２）および（３）に準じて、比較例２で製した大腸内視鏡検査用食品を摂食し、検査を行なったところ、大腸内粘膜を観察する際の内視鏡の視界の悪さは改善されておらず、検査に支障をきたした。 According to Example 1 (2) and (3), the food for colonoscopy produced in Comparative Example 2 was ingested and examined, and the field of view of the endoscope when observing the mucosa in the colon was observed. The badness of the test has not been improved, which has hindered the examination.
〔比較例３〕
実施例１（１）において、具材のジャガイモおよび牛肉の配合量をそれぞれ３０ｇ、５０ｇに変更し、ニンジンおよびトマトペーストを除いた以外は、実施例１（１）の方法に準じ、大腸内視鏡検査用食品を製した。この製した大腸内視鏡検査用食品は、１〜２７ｃｍ３のジャガイモおよびニンジンを含有し、１食当りの水溶性食物繊維を０．４ｇ、ソルビトール３ｇ、３〜１０糖類のマルトオリゴ糖を５ｇ含有するものであった。
[Comparative Example 3]
In Example 1 (1), the amounts of ingredients potato and beef were changed to 30 g and 50 g, respectively, and carrots and tomato paste were removed, and in accordance with the method of Example 1 (1), colonoscopy Food for mirror examination was made. This prepared food for colonoscopy contains 1-27 cm 3 of potato and carrot, 0.4 g of water-soluble dietary fiber per serving, 3 g of sorbitol, 5 g of maltooligosaccharide of 3-10 sugars It was something to do.
実施例１（２）および（３）に準じて、比較例３で製した大腸内視鏡検査用食品を摂食し、検査を行なったところ、大腸内粘膜を観察する際の内視鏡の視界の悪さは改善されておらず、検査に支障をきたした。 According to Example 1 (2) and (3), the food for colonoscopy produced in Comparative Example 3 was eaten and examined, and the field of view of the endoscope when observing the mucosa in the colon was observed. The badness of the test has not been improved, which has hindered the examination.
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