JP5224834B2 - Tablets containing processed plant products and panthetins - Google Patents

Description

  The present invention relates to tablets containing processed plant products having the desired mechanical strength and disintegration.

  In general, tablets are used in many pharmaceuticals, health foods, and the like because they are easy to ingest as one unit of measurement, easy to take, and relatively easy to produce. Tablets are packaged and then transported after being tableted. In this process, the tablet is subjected to considerable external forces such as vibration and impact. It must be tableted to have strength (hardness).

  On the other hand, in the case of internal medicine or the like, the effect is not exhibited unless it is disintegrated within a certain time after taking. For this reason, it is necessary to increase hardness and to impart moderate disintegration to the tablet.

  Increasing tableting pressure is known as one means for increasing the hardness of tablets (Non-patent Document 1). However, in the production of a tablet containing a plant extract, excessive tableting pressure is undesirable because it causes capping (peeling of the upper surface of the tablet), lamination (lamellar peeling), and the like during tableting. In addition to that, there is a big problem that the disintegration is lowered by increasing the hardness.

  As means for improving the disintegration of tablets, (1) Addition of disintegrants such as starch and cellulose, (2) Use of foaming action by acid-base reaction (addition of foaming agent), (3) Trace amount of lubricant (External lubrication) is known (Non-Patent Documents 2 and 3). However, since the blending amount of raw materials per tablet is limited, “addition of disintegrants and foaming agents” reduces the blending amount of active ingredients, etc. The problem was that the effect obtained with “Corporation” was small.

For this reason, there has been a demand for a method capable of increasing the hardness of the tablet and improving the disintegration property.
Pharmaceutical Development Basic Course X, Tablet Engineering, Jinshokan, 156, 1971 Immediately useful particle design and processing technology, Jiho, 221 pages, 2003 Pharm. Tech. Japan, Vol. 14, No. 11, p. 111, 1998

  Then, an object of this invention is to provide the tablet containing the plant processed material which has the effect excellent in the mechanical strength and the disintegration point.

  The inventor mixed all or part of the plant processed product and other ingredients constituting the tablet, granulated the mixture into granules, and then compressed the tablet by a conventional method to produce a tablet. In addition, the inventor mixed all the materials constituting the tablet, and then directly tableted the obtained mixture by a conventional method to produce a tablet. In this case, the tablet that was tableted through the former granulation process has higher hardness than the latter tablet that was directly tableted without going through the granulation process, and therefore the tablet strength can be changed by changing the manufacturing method. Improvement was observed. However, even in the case of the tablet, it is still insufficient as a tablet that can endure distribution as a commercial product.

  In addition, the present inventors added starches such as corn starch, which are known excipients to plant processed products, saccharides such as lactose and sucrose, binders such as starch paste and hydroxypropylcellulose, and the like. Many attempts were made to produce tablets. However, even in this case, the hardness and disintegration were not satisfactory.

The present inventor has made extensive studies in view of the above problems, and as a result, the hardness of the tablet containing the plant processed product is improved and the disintegration time is shortened by using the plant processed product and panthetin together. It was found that can be obtained. In other words, panthetins are considered to have the effect of improving the hardness of tablets containing processed plant products and shortening the disintegration time. The present invention has been completed as a result of further studies based on the above findings, and is described below.
(1) Tablet (1-1 ) A tablet containing a plant product and at least one panthetin selected from pantethine, pantethine salt, pantothenic acid, pantothenic acid salt, pantethein and panthenol.
(1-2) The tablet according to (1-1) above, wherein the plant processed product is a plant processed product containing at least one selected from the group consisting of Daio, Licorice, Mao, Peonies, Ogon, and Ginger. .
(1-3) The tablet according to (1-1) or (1-2) above, wherein the tablet has a vertical hardness of 6N or more.
(2) Hardness improver, disintegration improver (2-1) pantethine, pantethine salt, pantothenic acid, pantothenic acid salt, pantethein and panthenol as an active ingredient, Hardness improver for tablets containing processed plant products.
(2-2) Improvement of disintegration of tablets containing plant processed products containing at least one type of pantethine selected from pantethine, pantethine salt, pantothenic acid, pantothenic acid salt, pantethein and panthenol as an active ingredient Agent.
(2-3) Hardness and disintegration of tablets containing plant processed products containing as an active ingredient at least one pantethine selected from pantethine, pantethine salt, pantothenic acid, pantothenic acid salt, pantethein and panthenol Improver.
(3) Hardness improving method, disintegrating improving method (3-1) Plant processed product, and at least one pantethine selected from pantethine, pantethine salt, pantothenic acid, pantothenic acid salt, pantethein and panthenol A method for improving the hardness of a tablet containing a processed plant product.
(3-2) A tablet containing a processed plant product, wherein the processed plant product is used in combination with pantethine, a pantethine salt, pantothenic acid, a pantothenic acid salt, pantethein and panthenol. To improve the disintegration of
(3-3) A tablet containing a plant processed product, which is used in combination with a plant processed product and at least one panthetin selected from pantethine, pantethine salt, pantothenic acid, pantothenic acid salt, pantethein and panthenol Hardness and disintegration improvement method.

  The tablet of the present invention has a mechanical strength that can sufficiently withstand external forces such as vibrations and impacts received from tableting to taking. Moreover, the tablet of this invention has moderate disintegration which disintegrates in a fixed time after taking.

  In addition, according to the tablet of the present invention, based on the plant processed product and panthetin to be blended, the effect unique to the plant processed product, the effect on the cholesterol derived from the panthetin and the effect of activating the peristaltic movement of the intestine Can be obtained at the same time.

  In addition, according to the hardness and / or disintegration improver of the present invention containing pantethine as an active ingredient, the mechanical strength can be increased and the disintegration time can be shortened in tablets containing processed plant products. .

  In addition, according to the method for improving hardness and / or disintegration of the present invention, a tablet containing a processed plant product can have high mechanical strength, can shorten disintegration time, and has a desired effect. Can be obtained.

The tablet of the present invention is mainly characterized by containing a processed plant product and panthetins. Hereinafter, the configuration of the present invention will be described in detail.
(1) Plant processed product The raw material of the plant processed product used in the tablet of the present invention is not limited. For example, as a raw material for plant extract, Panax Ginseng, Panax pseudo-ginseng, Western Carrot (Panax quinquefolium Linne), Kanka (Cistanche Tubulosa) Plantago. Ovata Forsk Baillon, Rheum coreanum Nakai or interspecific hybrids), licorice (Glycyrrhiza uralensis Fischer, Glycyrrhiza glabra Linne), maou (Ephedra sinica Stapf, Ephedra intermedia Schrenk et CA Meyer, Ephedra equisetina Bunge), peonies (Peonia lactiflor) (Scutellariae baicalensis Georgi), Zingiber officinale Roscoe, Schizonepeta tenuifolia Briqu et), Forsythia suspense Vahl, Forsythia viridissima Lindley, Toki (Angelica acutiloba Kitagawa, Angelica acutiloba Kitagawa var. sugiyamae Hikino), Senkyu (Cnidium officinale Makino), Sanshin (Gardenia jasminoides Ellis. piperascens Malinvaud), Bowfish (Saposhnikovia divaricata Schischkin), Sandalwood (Atractylodes japonica Koidzumi ex Kitamura, Atractylodes ovata De Candolle), Pepper (Platycodon grandiflorum A. De Candolle), Psycho (Bupleuin bach) (Zizypus jujube Miller var. Inermis Rehder), pheasant (Citrus aurantium Linne var. Daidai Makino, Citrus aurantium Linne, Citrus natsudaidai Hayata), bowie (Sinomenium acutum Rehder et Wilson), ogi (Astragalus membranaceus m (Atractylodes lancea De Candolle, Atractyl plant such as odeschinensis Koidzumi). The processed plant product used in the tablet of the present invention preferably contains at least one selected from the group consisting of Daio, Licorice, Mao, Peonies, Ogon, and Ginger as its raw material.

  In the present invention, the processed plant product includes a pulverized product, a dried product, a solvent extract and the like as the raw material. The site of each plant to be used is not particularly limited as long as the processed product obtained from these plants has the desired effect of the present invention, and can be appropriately selected depending on the type of plant, for example, whole plant, rhizome, Examples include leaves, roots and fruits.

  The pulverized product of the plant is not particularly limited as long as the plant is pulverized by a pulverizer known in the art such as a jet mill.

  The dried product is not particularly limited as long as the plant is dried as it is. According to a conventionally known method such as sun drying, far-infrared irradiation, dryer (hot air drying, cold air drying, vacuum freeze drying) and the like. Can be obtained. The water content in the dried product is preferably 10% by weight or less, and more preferably 8% by weight or less. In the present invention, the form of the dried product is not limited, and any of a dried product of the plant itself and a pulverized product of the dried product may be used. In the case of a dry pulverized product, it can be obtained according to the same method as the pulverized product. Moreover, in this invention, what was obtained by drying after making the plant body (preferably especially rhizome part) used as a raw material into a dried material after fermentation treatment or an enzyme treatment can also be used.

  The method for obtaining the solvent extract is, for example, the above-mentioned plant, or a dried product or pulverized product thereof with water, hot water, an organic solvent (alcohol such as ethanol, methanol, isopropanol, propylene glycol, 1,3-butylene glycol; Water-containing alcohols such as water-containing ethanol and water-containing methanol; ether, hexane, benzene, chloroform, acetone, pentane, ethyl acetate and the like) or a mixture thereof, and a method of filtering. The extraction conditions are not particularly limited as long as they are generally applied to plant extraction. For example, 1 to 500 parts by weight, preferably 10 to 200 parts by weight of water with respect to 1 part by weight of the dried product. Or an organic solvent, and after stirring for about 1 to 300 minutes, preferably about 30 to 200 minutes with stirring at room temperature to about 100 ° C., preferably about 30 to 70 ° C., the solid content is removed by filtration. Can be mentioned. Ordinary methods for obtaining herbal medicines described in "Guide for general-purpose Kampo prescriptions" (supervised by the Pharmaceutical Affairs Bureau of the Ministry of Health and Welfare, edited by the National Pharmacopoeia Special Committee, published by Yakuho Hokpo)

  The solvent extract thus obtained is a liquid material in which the soluble components of the plant are dissolved in the extraction solvent.

  This liquid extract may be concentrated as necessary. As a concentration method, a conventional method such as an evaporator can be used. In addition, as a method of pulverizing the liquid extract in the present invention, for example, an excipient such as dextrin is added to the obtained solvent extract and dried according to a method known in the art such as spray drying. it can. Furthermore, purification operations such as deodorization and decolorization can be added as long as the effects derived from the plants that are the raw materials are not lost.

  The plant processed product can also be obtained after mixing two or more kinds of raw material plants in advance.

  The plant processed product used in the present invention is not particularly limited as long as the effects of the present invention are not impaired, but it is preferable to use a powder form of the solvent extract of each raw material. Conveniently, processed plant products that are commercially available can also be used. Processed plant products may be used alone or in combination of two or more.

  The blending ratio of the processed plant product in the tablet of the present invention is not particularly limited as long as the effects of the present invention are exhibited, but the total dry weight of the processed plant product in the tablet is usually about 0.1 to 98% by weight, preferably Examples include about 1 to 95% by weight, more preferably about 3 to 90% by weight, still more preferably about 10 to 90% by weight, and particularly preferably about 30 to 80% by weight. Here, when a plant extract is used as the processed plant product, it represents the dry weight of the obtained extract.

Further, in the case of using daioh, licorice, mao, peony, ogon and / or shoyu as the processed plant product, the blending amount is the dry weight of the processed plant product, usually 0.001 to 98 in the tablet. % By weight, more preferably about 0.01 to 95% by weight, more preferably about 0.03 to 90% by weight, still more preferably about 0.1 to 90% by weight, and particularly preferably 0.3 to 80% by weight. The degree is exemplified.
(2) Panthetins The tablet of the present invention is characterized by containing the above processed plant product and panthetins.

  In the present invention, the pantethine includes at least one selected from the group consisting of pantethine, pentetine salt, pantothenic acid, pantethein, panthenol, and pantothenic acid salt. The pantethine salt or pantothenic acid salt is not limited as long as it is pharmaceutically acceptable. For example, alkali metal salts such as sodium salt and potassium salt, alkaline earth metals such as calcium salt and magnesium salt, and hydrochloride salt And mineral acid salts such as nitrate and sulfate, and organic acid salts such as acetate, citrate and benzoic acid. These panthetins have a similar basic skeleton.

  The tablet of the present invention is blended alone or in combination of two or more selected from pantetins. As pantethine compounded in the tablet of the present invention, pantethine is preferable.

  Panthethine is represented as bis (2- {3-[(2R) -2,4-dihydroxy-3,3-dimethylbutanoylamino] propanoylamino} ethyl) disulfide, and pantothenic acid (vitamin B5) Also called derivatives or active vitamin B5.

  Pantethine is a known compound, and can be synthesized according to a conventionally known method. However, as pantethine, for example, a product such as pantethine A (Daiichi Sankyo Propharma) is also known and must be obtained commercially. You can also. Panthetins other than pantethine are also known and can be obtained according to conventional methods, and commercially available products can also be used.

  In the tablet of the present invention, the blending ratio of panthetins is not particularly limited as long as the effects of the present invention are exhibited, but is usually about 0.01 to 95% by weight, preferably about 0.1 to 80% by weight in terms of pantethine, More preferably, it is about 0.1 to 40% by weight.

In particular, when pantethine is used as the panthetin, the blending ratio thereof is usually about 0.01 to 95% by weight, preferably about 0.1 to 80% by weight, more preferably about 0.1 to 80% by weight in the tablet. About 40% by weight.
(3) Blending ratio of pantethines to processed plant product The blending ratio of panthetins to plant processed product in the tablet of the present invention is not particularly limited as long as the effect of the present invention is exhibited. Without excessive stickiness, for example, a tablet with low hygroscopicity can be suitably manufactured without adhering the mixture to the pestle or mortar used for tableting, and it also has an effect on panthetin-derived cholesterol and intestinal peristalsis. For example, the lower limit of the total amount of panthetins with respect to 100 parts by weight of the total amount of processed plant products is preferably 0.01, since the effect of activating and the like is not impaired and a tablet excellent in hardness and disintegration can be produced. Parts by weight, more preferably 0.1 parts by weight, still more preferably 0.125 parts by weight, particularly preferably 0.2 parts by weight. It is the amount part. Moreover, the upper limit of the total amount of panthetins is preferably 30 parts by weight, more preferably 28 parts by weight, and even more preferably 25 parts by weight. Here, as described above, when a plant extract is used as the processed plant product, the blending amount represents the dry weight of the obtained extract.

The processed plant product preferably contains at least one selected from the group consisting of daisou, licorice, mao, peony, oxon and ginger. In this case, the blending ratio in the total amount of processed plant of Daio, Licorice, Mao, Peonies, Ogon and / or Pepper is preferably 3% by weight or more, more preferably 5% by weight or more, and further preferably 7% by weight or more. .
(4) Size of tablet The size of the tablet of the present invention is not particularly limited as long as the effect of the present invention is exhibited, but is appropriately adjusted according to the use object, purpose of use and the like. For example, the size of the tablet of the present invention is exemplified by a size that is easy to take, preferably 18 mm or less, more preferably 15 mm or less, and even more preferably 12 mm or less. Further, the size of the tablet of the present invention is exemplified by a size that can be easily taken, preferably 10 mm or less in diameter, more preferably 9 mm or less, and still more preferably 8 mm or less.
(5) Other components that can be contained in tablets For the tablets of the present invention, for example, those conventionally known in the art can be widely used as carriers. Examples of such carriers include excipients such as lactose, sucrose, sodium chloride, glucose, urea, starch, calcium carbonate, kaolin, and silicic acid; water, ethanol, propanol, simple syrup, glucose solution, starch solution, gelatin Binders such as solution, carboxymethylcellulose, shellac, methylcellulose, potassium phosphate, polyvinylpyrrolidone, crystalline cellulose, hydroxypropylcellulose, hypromellose, sodium alginate; dry starch, agar powder, laminaran powder, sodium bicarbonate, polyoxyethylene sorbitan fatty acid Disintegrants such as esters, sodium lauryl sulfate, stearic acid monoglyceride, starch, crospovidone, povidone, low substituted hydroxypropylcellulose; stearin, cocoa butter, Disintegration inhibitors such as additive oils; Absorption accelerators such as quaternary ammonium salts and sodium lauryl sulfate; Moisturizers such as glycerin; Adsorbents such as starch, lactose, kaolin, bentonite, colloidal silicic acid; Purified talc, stearin Lubricants such as acid salts, boric acid powder and polyethylene glycol can be used. In addition to the above, the tablet of the present invention includes, for example, a surfactant, an absorption accelerator, an adsorbent, a filler, a preservative, a stabilizer, an emulsifier, a solubilizer, and a salt that adjusts osmotic pressure. Can be contained. Furthermore, in addition to the above, the tablet of the present invention may contain other active ingredients such as amino acids, vitamins, and organic acid salts. Examples of other active ingredients include valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Amino acids such as hydroxylysine, arginine, ornithine, histidine; vitamins such as vitamin A1, vitamin A2, carotene, lycopene (provitamin A), vitamin B6, vitamin B1, vitamin B2, ascorbic acid, nicotinamide, biotin; Examples include alkali metal salts such as sodium chloride and potassium chloride, and organic acid salts such as citrate, acetate and phosphate.

Further, the tablets can be made into tablets with ordinary coatings as necessary, for example, sugar-coated tablets, gelatin-encapsulated tablets, enteric-coated tablets, film-coated tablets, double tablets, and multilayer tablets.
(6) Manufacturing method of tablet The manufacturing method of the tablet of this invention is not specifically limited as long as the obtained tablet can exhibit a desired effect, It can manufacture in accordance with a conventionally well-known method. Further, specific materials of plant processed products and panthetins, their blending ratios, and the like are appropriately set according to the above description.

Usually, the processed plant product, panthetins, and other excipients or the like may be mixed as necessary, and tableted. For tableting, all of the compounding material may be directly compressed, or part or all of the compounding material may be granulated before tableting and then tableted according to conventional methods. Good.
(7) Tablet hardness and disintegration The hardness of the tablet of the present invention is not particularly limited as long as the effects of the present invention are exhibited. For example, the hardness in the vertical direction is preferably 6 N or more, more preferably 8 N or more, and still more preferably. 10N or more. In the present invention, the hardness of the tablet is measured using a Kiya type digital hardness meter KHT-20N type (Fujiwara Manufacturing Co., Ltd.).

The disintegration property of the tablet of the present invention is not particularly limited as long as the effect of the present invention can be obtained because it can be changed according to the size, shape, pressure at the time of tableting, etc. The reversal of the ratio of the disintegration time (T _X ) of the tablet made of plant processed products and panthetins to the disintegration time (T ₀ ) of the tablet consisting of the processed plant product alone, ie, (T ₀ / T _X ) The

  For example, an embodiment of the present invention will be described. As a processed plant product, a powdered extract of diam, licorice, mao, peony, ogon and / or ginger is used, and a convex tablet having a diameter of 9 mm is punched at a pressure of 25 Mpa. In the case of producing a tablet by tableting, improvement in disintegration (reduction of disintegration time) is not particularly limited, but it is preferably 5% or more, more preferably 8% or more, and further preferably 10% or more.

  The disintegration time of the tablet can be measured by the disintegration time measurement method described in the Japanese Pharmacopoeia. However, other test conditions may be set as appropriate, and the disintegration time in the aqueous solution may be measured. For example, a 100 ml beaker It is also possible to add about 80 cc of water at 37 ° C., rotate a 2 cm stirrer bar at 400 rpm, and measure the time from when the tablet is inserted until the tablet cannot be visually observed.

  The hygroscopicity of the tablet can be evaluated by observing the hygroscopicity (stickiness) of the tablet after leaving the obtained tablet at room temperature of 25 ° C. and humidity of 50% for 24 hours without packaging.

The daily intake of the tablet of the present invention can be appropriately changed according to the intake subject. For example, the daily dose for one adult (body weight 60 kg) is usually 0.01 in terms of the dry weight of the processed plant product. About 12 g, preferably about 0.05 to 10 g, more preferably about 0.07 to 8 g. Moreover, for example, when using the extract powder of daiou as a processed plant product, it is usually about 0.1 to 10 g, preferably about 1.0 to 8 g, more preferably about 1.5 to 6 g in terms of the total dry weight. is there. The pharmaceutical composition of the present invention is usually used in the form of oral administration divided into 2 to 3 times a day. The dose time is not particularly limited, but is preferably before or between meals.
(8) Hardness improver, disintegration improver The tablet hardness improver of the present invention comprises at least one pantethine selected from pantethine, pantethine salt, pantothenic acid, pantothenic acid salt, pantethein and panthenol. It is an active ingredient and can increase the hardness of a tablet containing a processed plant product. Specific materials of panthetins and processed plant products, their blending ratios, and the like are appropriately set according to the above description. Moreover, the said improvement agent is manufactured by tableting according to the manufacturing method of the said tablet.

  The tablet disintegration improver of the present invention comprises pantethine, pantethine salt, pantothenic acid, pantothenic acid salt, pantethein and panthenol as an active ingredient. The disintegration time of tablets containing processed plant products can be shortened. Specific materials of panthetins and processed plant products, their blending ratios, and the like are appropriately set according to the above description. Moreover, the said improvement agent is manufactured by tableting according to the manufacturing method of the said tablet.

The tablet hardness and disintegration improver of the present invention comprises at least one panthetin selected from pantethine, pantethine salt, pantothenic acid, pantothenic acid salt, pantethein and panthenol as an active ingredient. Yes, the hardness of the tablet containing the processed plant product can be increased, and the disintegration time can be shortened. Specific materials of panthetins and processed plant products, their blending ratios, and the like are appropriately set according to the above description. Moreover, the said improvement agent is manufactured by tableting according to the manufacturing method of the said tablet.
(9) Hardness improvement method, disintegration improvement method According to the hardness improvement method of the tablet of the present invention, it is selected from plant processed products, pantethine, pantethine salt, pantothenic acid, pantothenic acid salt, pantethein and panthenol By using together with at least 1 sort of panthetin, the hardness of the tablet containing a plant processed material can be raised. Specific materials of panthetins and processed plant products, their blending ratios, and the like are appropriately set according to the above description. Moreover, the said improvement agent is manufactured by tableting according to the manufacturing method of the said tablet.

  According to the method for improving disintegration of a tablet of the present invention, a processed plant product and pantethine, pantethine salt, pantothenic acid, pantothenic acid salt, pantethein and panthenol are used in combination. Thus, the disintegration time of the tablet containing the processed plant product can be shortened. Specific materials of panthetins and processed plant products, their blending ratios, and the like are appropriately set according to the above description. Moreover, the said improvement agent is manufactured by tableting according to the manufacturing method of the said tablet.

  According to the tablet hardness and disintegration improving method of the present invention, a plant processed product and at least one panthetin selected from pantethine, pantethine salt, pantothenic acid, pantothenic acid salt, pantethein and panthenol By using together, the hardness of the tablet containing a processed plant product can be increased, and the disintegration time can be shortened. Specific materials of panthetins and processed plant products, their blending ratios, and the like are appropriately set according to the above description. Moreover, the said improvement agent is manufactured by tableting according to the manufacturing method of the said tablet.

  According to the present invention, it is possible to impart superior hardness to tablets compared to the case where substances conventionally used as binders such as maltitol, mannitol and sorbitol are used in combination with plant processed products instead of pantethine. In addition, according to the present invention, hardness and / or disintegration time can be shortened even in a tablet containing a processed plant product, and further in a tablet containing a substance other than the processed plant product.

Hereinafter, the present invention will be described in more detail with reference to examples and formulation examples, but the present invention is not limited thereto.
Example 1
Using “Daiou extract powder” (manufactured by Mikuni Co., Ltd.) as a processed plant product, and “pantetin A” (manufactured by Daiichi Fine Chemical Co., Ltd.) which is an 80 wt% pantetin aqueous solution as pantetins, And mixed. The blending ratios in the table are the values calculated from the dry weight for Diou extract powder and the pantethine content (80% by weight) of pantethine A for pantethine, respectively. Using 0.36 g of the obtained mixture, a 9-diameter convex tablet was tableted using a hydraulic tableting machine SMP-3 (manufactured by Riken Seiki Co., Ltd.) at a pressure of 25 Mpa to obtain a tablet. At the time of tableting, it was confirmed whether or not the tablets adhered to the punch or mortar.

  About the obtained tablet, the hardness of the perpendicular | vertical direction was measured with respect to the tablet using the Kiya-type digital hardness meter KHT-20N type (made by Fujiwara Seisakusyo Co., Ltd.). The vertical direction is the direction of pressing and compressing with a scissors during tableting, and the horizontal direction is the direction perpendicular to the vertical direction.

Moreover, disintegration time was measured about the obtained tablet, and disintegration evaluation was performed compared with the tablet which consists of a wind-proof tsuyosan alone. Furthermore, the hygroscopicity of the obtained tablets was observed. The results of the average value of 10 tablets for each formulation are shown in Table 1.
(Measurement of disintegration time)
About 80 cc of 37 ° C. water was put into a 100 ml beaker, a 2 cm stirrer bar was rotated at 400 rpm, and the time from when the tablet was introduced until the tablet could no longer be observed visually was measured.

(Evaluation of disintegration)
Calculate the reciprocal of the ratio of the disintegration time (T _X ) of Fengtsu Sanseiki and the pantetins to the disintegration time (T ₀ ) of the tablet consisting of Fengtsu Sanseong alone, that is, (T ₀ / T _X ) And evaluated.

(Hygroscopic evaluation)
The tablets obtained were allowed to stand for 24 hours without packaging at room temperature of 25 ° C. and humidity of 50%, and the hygroscopicity of the tablets was observed. The case where the stickiness on the tablet surface was clearly recognized was judged as “×”, the case where it was slightly sticky was judged as “Δ”, and the case where stickiness was not found was judged as “◯”.

As is clear from Table 1, by adding pantethine to the powdered diao extract, an increase in hardness and a shortening of the disintegration time depending on the addition concentration of panthetins were observed. When the total amount of panthetins relative to 100 parts by weight of the daiou extract powder is 0.1 parts by weight, the tablet strength is markedly improved compared to tablets that do not contain pantetins. Furthermore, when the total amount of pantethines was 100 parts by weight with respect to 100 parts by weight of the diau extract powder, the tablet strength was further improved from the former. On the other hand, when the total amount of panthetins was 20 parts by weight with respect to 100 parts by weight of the diau extract powder, the hygroscopicity was not preferable.
Example 2
In Example 1, 50% by weight of pantethine fine granule “Pantosine (registered trademark) powder 50%” (Daiichi Sankyo Co., Ltd.) was used as the panthetin, and the mixture was mixed at the blending ratio shown in Table 2 below. Tablets were produced in the same manner as in Example 1, the hardness and disintegration time were measured, and the presence or absence of adhesion to the pestle or die during tableting and the hygroscopicity were observed. In addition, the compounding ratio of pantethine is a value calculated from the pantethine content (50% by weight) in the fine granules. The results of the average value of each tablet of 10 tablets are shown in Table 2.

As is apparent from Table 2, even when the pantethine fine granules were used, an increase in hardness and a reduction in disintegration time depending on the addition concentration of panthetins were observed as in Example 1.
Example 3
In Example 1, as a processed plant product, “licorice extract powder”, “mao extract powder”, “peony extract powder”, “ogon extract powder” or “falcon extract powder” (all manufactured by Mikuni Co., Ltd.) A tablet was obtained in the same manner as in Example 1 except that “Panthetine A” or “Pantosine powder 50%” was used. As a result, as in the case of Example 1, an increase in hardness and a shortening of the disintegration time depending on the addition concentration of panthetins were observed.
Examples 4 and 5
In Example 1 or 2, Daio 1.5 (parts by weight, the same applies hereinafter) and licorice 2.0 were extracted as processed plant products using 20 times the amount of water at about 100 ° C. for 1 hour and centrifuged. Obtained extract, concentrated under reduced pressure and dried using spray drying “Plant Extract Extract Powder A” (drying with a spray dryer drops the extract onto an atomizer with a rotational speed of 10000 rpm, hot air of 150 ° C. air Were used in the same manner as in Example 1 or 2, except that the above was used. The examples are referred to as Examples 4 and 5, respectively. The results of the average value of 10 tablets for each formulation are shown in Tables 3 and 4, respectively.

As is apparent from Tables 3 and 4, even when “plant extract powder A” is used, the increase in hardness and the shortening of the disintegration time dependent on the addition concentration of panthetins can be achieved as in Examples 1-3. It was watched.
Examples 6 and 7
In Example 1 or 2, as processed plant products, Toki 1.2 (parts by weight, the same applies hereinafter), Peonies 1.2, Senkyu 1.2, Sanshi 1.2, Forsythia 1.2, Hakka 1.2, Show Kyo 1.2, Kei-Gai 1.2, Bow-Fu 1.2, Maou 1.2, Dai-Oo 1.5, Bow-Sho 1.5, Sandalwood 2.0, Kyo-Jo 2.0, Ogon 2.0, Licorice 2.0, Gypsum 2.0 and Kasseki 3.0 were extracted with 20 times the amount of water at about 100 ° C. for 1 hour, centrifuged to obtain an extract, concentrated under reduced pressure, and dried using spray drying. Example 1 or 2 except that the plant extract powder B "(drying with a spray dryer was performed by dropping the extract into an atomizer with a rotational speed of 10000 rpm and supplying hot air at 150 ° C.) same A tablet was obtained. The examples are referred to as Examples 6 and 7, respectively. The results of the average value of 10 tablets for each formulation are shown in Tables 5 and 6, respectively.

As is clear from Tables 5 and 6, even when “plant extract powder B” was used, the increase in hardness and the shortening of the disintegration time dependent on the addition concentration of panthetins were achieved as in Examples 1-5. It was watched.
Example 8
In Example 1 or 2, tablets were obtained in the same manner as in Example 1 or 2 except that Plantagogobata, Ginseng, Panax ginseng, Western ginseng or Kanka were used as plant processed products. Each processed plant product was obtained by extracting at about 100 ° C. for 1 hour using 20 times the amount of water, centrifuging to obtain an extract, concentrating under reduced pressure, and drying using spray drying. Drying with a spray dryer was performed by dropping the extract into an atomizer with a rotational speed of 10,000 rpm and supplying hot air of 150 ° C. air. Tables 7 and 8 show the average results of 10 tablets for each prescription when using ginseng.

As is clear from Tables 7 and 8, when ginseng was used, an increase in hardness was observed as in Example 1 and a decrease in disintegration time depending on the addition concentration of panthetins was observed. Were higher in Examples 1-7. The same tendency as for ginseng was observed when plantagogobata, seven ginseng, western ginseng or kanka were used.
Comparative Examples 1-3
In Example 1, instead of pantethine, maltitol (“Resis” manufactured by Towa Kasei Kogyo Co., Ltd .: Comparative Example 1), mannitol (“Mannitol” manufactured by Saneigen FFI Co., Ltd .: Comparative Example 2) or sorbitol (Sorbitol (manufactured by San-Ei Gen FFI Co., Ltd.): Comparative Example 3) was used, and tablets were obtained in the same manner as in Example 1 except that they were mixed at the blending ratios shown in Tables 9 to 11 below. Maltitol, mannitol and sorbitol are usually used as binders. The result of the average value of 10 tablets of each prescription is shown in Tables 9-11.

As is apparent from Tables 9-11, the desired increase in hardness was not observed when maltitol, mannitol or sorbitol, which are commonly used as binders, were added.
Formulation Examples 1-3
According to prescription examples 1 to 30, tablets were produced by a conventional method.

Claims (5)

Dianthus, Daylily, Maou, Peonies, Ogon, Pepper, and Toki, Peonies, Senkyu, Ganoderma, Forsythia, Pepper, Pepper, Keigai, Bowfou, Mao, Daio, Pepper, Peacock, Pepper, Pepper, Pepper Inclusion of a plant workpiece comprising at least one, pantethine, salts of pantethine, pantothenic acid, salts of pantothenic acid, and at least one pantethine compounds selected from pantetheine and panthenol selected from the group consisting of Tablets. The tablet according to claim 1, wherein the processed plant product is a processed plant product containing at least one selected from the group consisting of daisou, licorice, mao, peony, ogon and ginger. The tablet according to claim 1 or 2, wherein the tablet has a vertical hardness of 6N or more. Pantethine, Pantethine salt, Pantothenic acid, Pantothenic acid salt, Pantethein and Panthenol selected from Pantethein and Panthenol as an active ingredient, Dio, licorice, mao, peonies, oxon, ginger, Plant processing comprising at least one selected from the group consisting of peonies, senkyu, shirashi, forsythia, mint, shrimp, mussel, bowfish, mao, daiou, bowshaw, peony, kyoto, ogon, licorice, gypsum and casserole Hardness and disintegration improver for tablets containing products. Dianthus, Daylily, Maou, Peonies, Ogon, Pepper, and Toki, Peonies, Senkyu, Ganoderma, Forsythia, Pepper, Pepper, Keigai, Bowfou, Mao, Daio, Pepper, Peacock, Pepper, Pepper, Pepper Combined use of a plant processed product containing at least one selected from the group consisting of a mixture of the above and at least one panthetin selected from pantethine, pantethine salt, pantothenic acid, pantothenic acid salt, pantethein and panthenol A method for improving the hardness and disintegration of a tablet containing a processed plant product.