JP5215350B2 - Manufacturing method of artificial bone model having cutting ability very similar to natural bone - Google Patents
Manufacturing method of artificial bone model having cutting ability very similar to natural bone Download PDFInfo
- Publication number
- JP5215350B2 JP5215350B2 JP2010115447A JP2010115447A JP5215350B2 JP 5215350 B2 JP5215350 B2 JP 5215350B2 JP 2010115447 A JP2010115447 A JP 2010115447A JP 2010115447 A JP2010115447 A JP 2010115447A JP 5215350 B2 JP5215350 B2 JP 5215350B2
- Authority
- JP
- Japan
- Prior art keywords
- artificial bone
- divided
- bone
- bone model
- artificial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000000988 bone and bone Anatomy 0.000 title claims description 180
- 238000004519 manufacturing process Methods 0.000 title claims description 39
- 238000005520 cutting process Methods 0.000 title claims description 28
- 239000000843 powder Substances 0.000 claims description 72
- 239000000463 material Substances 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 20
- 238000005245 sintering Methods 0.000 claims description 19
- 229920003002 synthetic resin Polymers 0.000 claims description 19
- 239000000057 synthetic resin Substances 0.000 claims description 19
- 238000012549 training Methods 0.000 claims description 13
- 239000011256 inorganic filler Substances 0.000 claims description 10
- 229910003475 inorganic filler Inorganic materials 0.000 claims description 10
- 238000003325 tomography Methods 0.000 claims description 7
- 239000010419 fine particle Substances 0.000 claims description 6
- 230000001678 irradiating effect Effects 0.000 claims description 4
- 239000011148 porous material Substances 0.000 claims description 2
- 210000003582 temporal bone Anatomy 0.000 description 18
- 238000001356 surgical procedure Methods 0.000 description 12
- 239000000654 additive Substances 0.000 description 9
- 230000000996 additive effect Effects 0.000 description 9
- 238000002591 computed tomography Methods 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 239000000853 adhesive Substances 0.000 description 4
- 230000001070 adhesive effect Effects 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- -1 polyethylene Polymers 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 229920000571 Nylon 11 Polymers 0.000 description 2
- 239000004830 Super Glue Substances 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000002316 cosmetic surgery Methods 0.000 description 2
- FGBJXOREULPLGL-UHFFFAOYSA-N ethyl cyanoacrylate Chemical compound CCOC(=O)C(=C)C#N FGBJXOREULPLGL-UHFFFAOYSA-N 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 230000000399 orthopedic effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 210000000115 thoracic cavity Anatomy 0.000 description 2
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 229930182556 Polyacetal Natural products 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000012461 cellulose resin Substances 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 210000003477 cochlea Anatomy 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000003027 ear inner Anatomy 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000000256 facial nerve Anatomy 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000010445 mica Substances 0.000 description 1
- 229910052618 mica group Inorganic materials 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920001748 polybutylene Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 210000002480 semicircular canal Anatomy 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000010456 wollastonite Substances 0.000 description 1
- 229910052882 wollastonite Inorganic materials 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Images
Landscapes
- Instructional Devices (AREA)
Description
本発明は、自然骨と酷似した切削性を有する人工骨モデルの製造方法に関する。さらに詳しくは、本発明は、教育訓練用や、術前治療計画の検討用などとして用いられる切削性を有する人工骨モデルを、粉末焼結積層造形法により、自然骨と酷似させて製造する方法に関するものである。 The present invention relates to a method for manufacturing an artificial bone model having a cutting ability very similar to natural bone. More specifically, the present invention relates to a method for manufacturing an artificial bone model having cutting properties used for education and training, for studying a preoperative treatment plan, or the like, by using a powder sintering additive manufacturing method so as to resemble natural bone. It is about.
欠損や変形を生じた頭蓋骨の治療、骨が複雑に組み合わされている聴覚器官の治療、大腿骨頭壊死の外科的治療、各種の複雑骨折の治療など、骨の切削を伴う治療が、整形外科、脳外科、胸部外科、口腔外科、耳鼻咽喉科、形成外科、獣医外科などの広い分野で行われている。しかし、骨の切削を伴う外科的治療に熟達した医師を養成するための教育訓練の機会は多くない。 Treatment with bone cutting, such as treatment of skulls with defects or deformation, treatment of auditory organs with complex bones, surgical treatment of femoral head necrosis, treatment of various complex fractures, orthopedics, It is performed in a wide range of fields such as brain surgery, thoracic surgery, oral surgery, otolaryngology, plastic surgery, and veterinary surgery. However, there are not many opportunities for training to train doctors who are proficient in surgical treatment with bone cutting.
従来、医療関係の教育、訓練、実験などに用いられる教材としては、人間などの、動物の遺体から採取した骨の外観を目視により模倣し、紙、合成樹脂、木材、石膏などの材料を用いて、彫刻、切削などの手法、いわゆる芸術的センスにより製作された模型が一般的に用いられている。稀に、一部の医療機関や教育機関では、採取した人体や動物の部位そのものが、故人あるいは遺族の好意により、死後献体として実体が用いられる場合がある。しかし、教育、訓練、実験用などとしての骨の入手は困難な状況にある。 Conventionally, as teaching materials used for medical education, training, experiments, etc., materials such as paper, synthetic resin, wood, plaster, etc. are used to visually imitate the appearance of bones collected from the remains of animals such as humans. In general, models made by techniques such as engraving and cutting, so-called artistic sense, are generally used. In rare cases, in some medical institutions and educational institutions, the collected human body or animal part itself may be used as a post-mortem donation, in favor of the deceased or bereaved. However, it is difficult to obtain bones for education, training and experimentation.
さらに、整形外科、脳神経外科、胸部外科、口腔外科、耳鼻咽喉科、形成外科、獣医外科などの広い分野の外科領域において、特に若い医師にとって術者としての経験を重ねることが必要とされているにも関わらず、これらの教材の入手困難な状況は深刻である。 Furthermore, there is a need for experience as a surgeon, especially for young doctors, in a wide range of surgical fields such as orthopedics, neurosurgery, thoracic surgery, oral surgery, otolaryngology, plastic surgery, veterinary surgery, etc. Nevertheless, the difficulty of obtaining these materials is serious.
また、これら若手医師たちにとっては、昨今著しい進歩を遂げている医用画像機器特にＣＴ（Computer Tomography）の画像所見と実際の解剖所見を結びつけ、さらに解剖学的名称を正確に把握しておくことが非常に重要である。さらには、やはり近年目覚しい進歩を遂げている各種手術器具・装置・用具に関しても習熟のための充分な機会が求められている。 In addition, for these young doctors, it is necessary to link the image findings of medical imaging equipment, especially CT (Computer Tomography), which has made remarkable progress, with the actual anatomical findings, and to accurately grasp the anatomical names. Very important. Furthermore, sufficient opportunities for learning are required for various surgical instruments, devices, and tools that have made remarkable progress in recent years.
この改善策として、近年医学系学術集会においては、各科ともそれぞれ若手医師を対象としたハンズオンセミナーとしてトレーニングを実施しているが、学術集会の会場では献体を使用することができず、また従来のトレーニング用モデルでは、実際の手術の際に経験する事柄、すなわち、目視上の解剖学的近似性、手術器具・装置を用いた使用感（自然骨に酷似した切削性）を得ることができないのが現状である。したがって、外科系各科の若手医師に容易に画像所見と解剖所見を一致させ、最新の手術器具・装置を自然骨に酷似した状況で削開する使用感を提供することが急務となっている。
人工骨モデルの製造方法については、特許文献１に粉末焼結積層造形法による、切削性を有する人工骨モデルの製造方法が開示されている。
As a measure to improve this, in recent medical science meetings, each department has conducted training as a hands-on seminar for young doctors, but donations cannot be used at the venues of academic meetings. With the training model, it is impossible to obtain the things experienced during actual surgery, that is, the visual anatomical approximation, the feeling of use using surgical instruments and devices (cutting ability very similar to natural bone) is the current situation. Therefore, there is an urgent need to provide a usability to easily match the image findings and anatomical findings to young doctors in various surgical departments, and to cut the latest surgical instruments and devices in a situation very similar to natural bones. .
Regarding a method for manufacturing an artificial bone model, Patent Document 1 discloses a method for manufacturing an artificial bone model having cutting properties by a powder sintering additive manufacturing method.
しかしながら、前記特許文献１に記載の人工骨モデルの製造方法では、人体などの自然骨の立体的形状を、精密かつ正確に３次元的に複製することができるが、その特殊な製造方法により、骨に該当する部位以外の空洞部分に粉末材料が未硬化のまま残留してしまい、骨に該当する部分を削開した際に、自然骨を削開した際に目視できる解剖学的所見とは異なっており、水若しくは空気にて一旦空洞箇所に残留した粉末を除去しなければならないという問題があった。
本発明は、このような状況下になされたものであり、教育訓練用や、術前治療計画の検討用などとして用いられる切削性を有する人工骨モデルを、自然骨と酷似させて製造する方法を提供することを目的とするものである。
However, in the method for manufacturing an artificial bone model described in Patent Document 1, the three-dimensional shape of a natural bone such as a human body can be accurately and accurately reproduced three-dimensionally. What is the anatomical observation that can be seen when the natural bone is cut when the powder material remains uncured in the hollow part other than the part corresponding to the bone and the part corresponding to the bone is cut off? There is a problem in that the powder remaining in the cavity must be removed once with water or air.
The present invention has been made under such circumstances, and a method for manufacturing an artificial bone model having a cutting property used for education and training, for studying a preoperative treatment plan, or the like, that closely resembles natural bone. Is intended to provide.
本発明者らは、前記目的を達成するために鋭意研究を重ねた結果、下記の知見を得た。
自然骨の３次元ＣＡＤデータを所定の分割面によって２以上に分割して、各分割自然骨の３次元ＣＡＤデータを得て、該３次元ＣＡＤデータに基づいて得た各分割自然骨の断層撮影情報に基づき、各分割自然骨の人工骨モデルを、粉末焼結積層造形法により別々に製造したのち、各分割人工骨モデルの分割面に露出している開口から焼結していない粉末を除去してから、全ての各分割人工骨モデルを分割面で接着して一体的人工骨モデルを形成することにより、その目的を達成し得ることを見出した。本発明は、かかる知見に基づいて完成したものである。
As a result of intensive studies to achieve the above object, the present inventors have obtained the following knowledge.
Three-dimensional CAD data of natural bone is divided into two or more by a predetermined dividing plane, three-dimensional CAD data of each divided natural bone is obtained, and tomography of each divided natural bone obtained based on the three-dimensional CAD data Based on the information, artificial bone models of each divided natural bone are manufactured separately by powder sintering additive manufacturing method, and then the unsintered powder is removed from the opening exposed on the divided surface of each divided artificial bone model Then, it has been found that the object can be achieved by forming an integral artificial bone model by bonding all the divided artificial bone models at the dividing plane. The present invention has been completed based on such findings.
すなわち、本発明は、
（１）自然骨の３次元ＣＡＤデータを所定の分割面によって２以上に分割して、各分割自然骨の３次元ＣＡＤデータを得て、該３次元ＣＡＤデータに基づいて得た各分割自然骨の断層撮影情報に基づき、各分割自然骨の人工骨モデルを別々に製造したのち、各分割自然骨の人工骨モデルを接着する自然骨の人工骨モデルの製造方法であって、
各分割自然骨の人工骨モデルを別々に製造するに当たり、合成樹脂粉末３０〜９０質量％と無機充填剤１０〜７０質量％からなる粉末焼結材料を薄層状に展開し、薄層状に展開した１層分の粉末焼結材料に、各分割自然骨の断層撮影情報に基づく外観形状及び内部構造形状をレーザ光により照射して、薄層状に展開した１層分の粉末焼結材料の該レーザ光の照射部分を焼結し、さらに、１層分の粉末焼結材料の薄層状の展開と、自然骨の断層撮影情報に基づく外観形状及び内部構造形状をレーザ光により照射して薄層状に展開した１層分の粉末焼結材料の焼結とを反復して繰り返すことにより、各分割自然骨の外観形状と内部構造形状を三次元的に複製した各部分の人工骨モデルを別々に製造し、各分割人工骨モデルの分割面に露出している開口から焼結していない粉末を除去してから、全ての各分割人工骨モデルを分割面で接着して一体的人工骨モデルを形成することを特徴とする自然骨と酷似した切削性を有する人工骨モデルの製造方法、
（２）各分割人工骨モデルの分割面に露出している開口から焼結していない粉末を除去してから、除去された空孔の内面を着色する上記(１)項記載の自然骨と酷似した切削性を有する人工骨モデルの製造方法、
（３）合成樹脂粉末の微粒子が、球状である上記(１)又は(２)項記載の自然骨と酷似した切削性を有する人工骨モデルの製造方法、
（４）人工骨モデルが、教育訓練用である上記(１)〜(３)項の何れかに記載の自然骨と酷似した切削性を有する人工骨モデルの製造方法、及び
（５）人工骨モデルが、術前治療計画の検討用である上記(１)〜(３)項の何れかに記載の自然骨と酷似した切削性を有する人工骨モデルの製造方法、
を提供するものである。
That is, the present invention
(1) Three-dimensional CAD data of natural bone is divided into two or more by a predetermined dividing surface, three-dimensional CAD data of each divided natural bone is obtained, and each divided natural bone obtained based on the three-dimensional CAD data A method for producing an artificial bone model of a natural bone, wherein an artificial bone model of each divided natural bone is manufactured separately based on the tomographic information of
In separately producing artificial bone models of each divided natural bone, a powder sintered material composed of 30 to 90% by mass of a synthetic resin powder and 10 to 70% by mass of an inorganic filler was developed into a thin layer and developed into a thin layer. The laser of the powder sintered material for one layer developed in a thin layer by irradiating the powder sintered material for one layer with the laser beam on the appearance shape and internal structure shape based on the tomographic information of each divided natural bone Sinter the irradiated part of the light, and further develop a thin layer of powder sintering material for one layer and irradiate the external shape and internal structure shape based on tomography information of natural bone with laser light into a thin layer By repeatedly repeating the sintering of the expanded powder sintering material for one layer, the artificial bone model of each part that replicates the appearance shape and internal structure shape of each divided natural bone three-dimensionally is manufactured separately. And exposed on the split surface of each split artificial bone model After removing unsintered powder from the mouth, all the divided artificial bone models are bonded at the dividing surface to form an integral artificial bone model, which has a cutting ability very similar to natural bone Manufacturing method of artificial bone model,
(2) After removing unsintered powder from the opening exposed on the divided surface of each divided artificial bone model, coloring the inner surface of the removed pores, A method of manufacturing an artificial bone model having very similar cutting properties;
(3) A method for producing an artificial bone model having cutting properties very similar to natural bone according to (1) or (2) above, wherein the fine particles of the synthetic resin powder are spherical,
(4) The method for producing an artificial bone model having cutting ability very similar to natural bone according to any one of (1) to (3) above, wherein the artificial bone model is for education and training, and (5) artificial bone The method for producing an artificial bone model having a cutting ability very similar to that of natural bone according to any one of (1) to (3) above, wherein the model is for examination of a preoperative treatment plan,
Is to provide.
本発明によれば教育訓練用や、術前治療計画の検討用などとして用いられる切削性を有する人工骨モデルを、粉末焼結積層造形法により、自然骨と酷似させて製造する方法を提供することができる。 According to the present invention, there is provided a method of manufacturing an artificial bone model having a cutting property used for education and training, for studying a preoperative treatment plan, or the like, by using a powder sintering additive manufacturing method so as to resemble natural bone. be able to.
本発明の自然骨と酷似した切削性を有する人工骨モデルの製造方法（以下、単に「人工骨モデルの製造方法」と称することがある。）は、自然骨の３次元ＣＡＤデータを所定の分割面によって２以上に分割して、各分割自然骨の３次元ＣＡＤデータを得て、該３次元ＣＡＤデータに基づいて得た各分割自然骨の断層撮影情報に基づき、各分割自然骨の人工骨モデルを別々に製造したのち、各分割自然骨の人工骨モデルを接着する自然骨の人工骨モデルの製造方法であって、
各分割自然骨の人工骨モデルを別々に製造するに当たり、合成樹脂粉末３０〜９０質量％と無機充填剤１０〜７０質量％からなる粉末焼結材料を薄層状に展開し、薄層状に展開した１層分の粉末焼結材料に、各分割自然骨の断層撮影情報に基づく外観形状及び内部構造形状をレーザ光により照射して、薄層状に展開した１層分の粉末焼結材料の該レーザ光の照射部分を焼結し、さらに、１層分の粉末焼結材料の薄層状の展開と、自然骨の断層撮影情報に基づく外観形状及び内部構造形状をレーザ光により照射して薄層状に展開した１層分の粉末焼結材料の焼結とを反復して繰り返すことにより、各分割自然骨の外観形状と内部構造形状を三次元的に複製した各部分の人工骨モデルを別々に製造し、各分割人工骨モデルの分割面に露出している開口から焼結していない粉末を除去してから、全ての各分割人工骨モデルを分割面で接着して一体的人工骨モデルを形成することを特徴とする。
The method for manufacturing an artificial bone model having cutting ability very similar to that of natural bone according to the present invention (hereinafter sometimes simply referred to as “artificial bone model manufacturing method”) divides the three-dimensional CAD data of the natural bone into predetermined segments. Divided into two or more according to the plane, three-dimensional CAD data of each divided natural bone is obtained, and based on the tomographic information of each divided natural bone obtained based on the three-dimensional CAD data, the artificial bone of each divided natural bone A method for producing an artificial bone model of natural bone, wherein the model is manufactured separately, and then each divided natural bone artificial bone model is bonded.
In separately producing artificial bone models of each divided natural bone, a powder sintered material composed of 30 to 90% by mass of a synthetic resin powder and 10 to 70% by mass of an inorganic filler was developed into a thin layer and developed into a thin layer. The laser of the powder sintered material for one layer developed in a thin layer by irradiating the powder sintered material for one layer with the laser beam on the appearance shape and internal structure shape based on the tomographic information of each divided natural bone Sinter the irradiated part of the light, and further develop a thin layer of powder sintering material for one layer and irradiate the external shape and internal structure shape based on tomography information of natural bone with laser light into a thin layer By repeatedly repeating the sintering of the expanded powder sintering material for one layer, the artificial bone model of each part that replicates the appearance shape and internal structure shape of each divided natural bone three-dimensionally is manufactured separately. And exposed on the split surface of each split artificial bone model Following removal of the powder that is not sintered mouth, and forming an integral artificial bone model by bonding a split face all of the divided artificial bone model.
［各分割自然骨の人工骨モデルの作製］
本発明の人工骨モデルの製造方法においては、まず自然骨の３次元ＣＡＤデータを所定の分割面によって２以上に分割して、各分割自然骨の３次元ＣＡＤデータを得たのち、該３次元ＣＡＤデータに基づいて得られた各分割自然骨の断層撮影情報に基づき、各分割自然骨の人工骨モデルを、粉末焼結積層造形法により、別々に作製する。
[Production of artificial bone model of each divided natural bone]
In the method for producing an artificial bone model of the present invention, first, the three-dimensional CAD data of natural bone is divided into two or more by a predetermined dividing surface, and the three-dimensional CAD data of each divided natural bone is obtained. Based on the tomography information of each divided natural bone obtained based on the CAD data, artificial bone models of each divided natural bone are separately produced by a powder sintering additive manufacturing method.
（自然骨の３次元ＣＡＤデータ）
自然骨の３次元ＣＡＤデータは、人体の各部位の自然骨を、磁気共鳴映像法（ＭＲＩ）、Ｘ線コンピュータ断層撮影（Ｘ線ＣＴ）、超音波コンピュータ断層撮影（超音波ＣＴ）などのいずれか１種又は２種以上の複合方法を用いて透視計測又は外形計測したものである。得られた人体から実測した各部位の自然骨の三次元的立体形状と寸法データは、例えば、医用デジタル画像と通信（ＤＩＣＯＭ、Digital Imaging and Communications in Medicine）データを、さらにソリッドタイプのＳＴＬ（Standard Trianglation language）フォーマットデータに変換することにより、粉末焼結積層造形法に適用することが可能となり、このデータに基づいて粉末焼結積層造形装置におけるレーザ光を稼動させることができる。
本発明においては、上記自然骨の３次元ＣＡＤデータを、所定の分割面によって２以上、通常２〜５に分割して、各分割自然骨の３次元ＣＡＤデータを得たのち、この３次元ＣＡＤデータに基づいて得られた各分割自然骨の断層撮影情報に基づき、粉末焼結積層造形法によって、各分割自然骨の人工骨モデルを別々に作製する。
(3D CAD data of natural bone)
The natural bone 3D CAD data can be obtained by analyzing the natural bone of each part of the human body, such as magnetic resonance imaging (MRI), X-ray computed tomography (X-ray CT), or ultrasonic computed tomography (ultrasound CT). These are fluoroscopic measurement or external shape measurement using one or two or more combined methods. The three-dimensional shape and dimension data of the natural bone of each part actually measured from the obtained human body are, for example, medical digital image and communication (DICOM, Digital Imaging and Communications in Medicine) data, and solid type STL (Standard By converting to format data, it becomes possible to apply to the powder sintering additive manufacturing method, and based on this data, the laser light in the powder sintering additive manufacturing apparatus can be operated.
In the present invention, the three-dimensional CAD data of the natural bone is divided into two or more, usually 2 to 5 by a predetermined dividing plane, and the three-dimensional CAD data of each divided natural bone is obtained. Based on the tomographic information of each divided natural bone obtained based on the data, artificial bone models of each divided natural bone are separately produced by the powder sintering additive manufacturing method.
（粉末焼結材料）
本発明の人工骨モデルの製造方法において用いる粉末焼結材料は、レーザ光の照射により焼結する材料であって、合成樹脂粉末３０〜９０質量％と無機充填剤１０〜７０質量％からなり、好ましくは合成樹脂粉末５０〜８０質量％と無機充填剤２０〜５０質量％からなる。合成樹脂粉末が３０質量％未満で無機充填剤が７０質量％を超えると、得られる人工骨モデルが硬く、脆くなるとともに、自然骨の切削性から外れるおそれがある。合成樹脂粉末が９０質量％を超え無機充填剤が１０質量％未満であると、得られる各分割人工骨モデルの切削性が不良となるおそれがある。合成樹脂粉末と無機充填剤の配合比を調整することにより、得られる人工骨モデルの硬軟や柔脆の程度を調節することができるので、硬い老人の骨から、軟らかい子供の骨まで、目的に応じた人工骨モデルを作製することができる。
(Powder sintered material)
The powder sintered material used in the method for producing an artificial bone model of the present invention is a material that is sintered by laser light irradiation, and is composed of synthetic resin powder 30 to 90% by mass and inorganic filler 10 to 70% by mass, Preferably, it consists of synthetic resin powder 50-80 mass% and inorganic filler 20-50 mass%. If the synthetic resin powder is less than 30% by mass and the inorganic filler exceeds 70% by mass, the resulting artificial bone model becomes hard and brittle, and may deviate from the machinability of natural bone. If the synthetic resin powder exceeds 90 mass% and the inorganic filler is less than 10 mass%, the machinability of each obtained divided artificial bone model may be poor. By adjusting the blending ratio of synthetic resin powder and inorganic filler, it is possible to adjust the degree of softness and softness of the resulting artificial bone model, so that it can be used for hard bones of elderly people and bones of soft children. A corresponding artificial bone model can be produced.
＜合成樹脂粉末＞
本発明方法に用いる合成樹脂粉末に特に制限はなく、例えば、ナイロン、ポリカーボネート、ポリエステル、ポリアセタール、ポリエチレン、ポリプロピレン、ポリ塩化ビニル、ポリスチレン、ポリブチレン、ＡＢＳ樹脂、セルロース系樹脂、アクリル樹脂、エポキシ樹脂、フッ素樹脂などを挙げることができる。これらは１種を単独で用いてもよいし、２種以上を組み合わせて用いてもよいが、これらの中で、ナイロンを好適に用いることができ、ナイロン１１を特に好適に用いることができる。
本発明方法においては、合成樹脂粉末の微粒子が球状であることが好ましい。合成樹脂粉末の微粒子を球状とすることにより、均一な厚みで空隙率の小さい粉末焼結材料の薄層を、再現性よく形成することができる。
また、本発明においては、得られた各分割人工骨モデルの分割面に露出している開口から、焼結していない粉末を除去する必要があるが、該合成樹脂粉末の微粒子が球状であれば、焼結していない粉末の除去が容易となる。
<Synthetic resin powder>
The synthetic resin powder used in the method of the present invention is not particularly limited. For example, nylon, polycarbonate, polyester, polyacetal, polyethylene, polypropylene, polyvinyl chloride, polystyrene, polybutylene, ABS resin, cellulose resin, acrylic resin, epoxy resin, fluorine Examples thereof include resins. One of these may be used alone, or two or more may be used in combination. Among these, nylon can be preferably used, and nylon 11 can be particularly preferably used.
In the method of the present invention, the fine particles of the synthetic resin powder are preferably spherical. By making the fine particles of the synthetic resin powder spherical, a thin layer of a powder sintered material having a uniform thickness and a small porosity can be formed with good reproducibility.
Further, in the present invention, it is necessary to remove the unsintered powder from the openings exposed on the divided surfaces of the obtained divided artificial bone models, but the fine particles of the synthetic resin powder should be spherical. In this case, it becomes easy to remove the unsintered powder.
合成樹脂粉末の微粒子の大きさに特に制限はないが、平均粒径５〜２００μｍであることが好ましく、平均粒径２０〜１２０μｍであることがより好ましく、平均粒径４０〜９０μｍであることがさらに好ましい。平均粒径が５μｍ未満の合成樹脂粉末は、製造が容易でなく、コスト高になるおそれがある。合成樹脂粉末の平均粒径が２００μｍを超えると、得られる人工骨モデルの均一性が低下し、切削性が不良となるおそれがあり、また開口からの除去性が低下するおそれがある。 Although there is no restriction | limiting in particular in the magnitude | size of the microparticles | fine-particles of synthetic resin powder, it is preferable that it is an average particle diameter of 5-200 micrometers, it is more preferable that it is average particle diameter of 20-120 micrometers, and it is that average particle diameter is 40-90 micrometers. Further preferred. Synthetic resin powder having an average particle size of less than 5 μm is not easy to produce and may increase costs. When the average particle size of the synthetic resin powder exceeds 200 μm, the uniformity of the resulting artificial bone model is lowered, the cutting performance may be poor, and the removability from the opening may be lowered.
＜無機充填剤＞
本発明方法に用いる無機充填剤に特に制限はなく、例えば、タルク、炭酸カルシウム、ガラスビーズ、シリカ、クレー、カオリン、硫酸バリウム、ウォラストナイト、雲母、酸化チタン、ケイソウ土、ヒドロキシアパタイト、金属粉末などを挙げることができる。これらは１種を単独で用いてもよいし、２種以上を組み合わせて用いてもよいが、これらの中で、ガラスビーズは、切削性の良好な人工骨モデルを得ることができるので、特に好適に用いることができる。
<Inorganic filler>
There are no particular limitations on the inorganic filler used in the method of the present invention. For example, talc, calcium carbonate, glass beads, silica, clay, kaolin, barium sulfate, wollastonite, mica, titanium oxide, diatomaceous earth, hydroxyapatite, metal powder And so on. One of these may be used alone, or two or more may be used in combination, but among these, glass beads can obtain an artificial bone model with good cutting properties. It can be used suitably.
＜レーザ光＞
本発明方法に用いるレーザ光に特に制限はなく、例えば、ＣＯ2レーザ、ＹＡＧレーザ、エキシマレーザ、Ｈｅ−Ｃｄレーザ、半導体励起固体レーザなどを挙げることができる。これらの中で、ＣＯ2レーザは、操作が簡単で、制御が容易なので、特に好適に用いることができる。これらのレーザは、１種を単独で用いることができ、あるいは、２種以上を組み合わせて用いることもできる。使用するレーザの種類によって、製造時間、粉末焼結材料の結合の程度、得られる人工骨モデルの気孔率などを調節することができる。
本発明方法において、粉末焼結材料にレーザ光を照射するときの雰囲気に特に制限はなく、例えば、水素、ヘリウム、アルゴン、窒素などのガス中とすることができ、あるいは、大気中とすることもできる。雰囲気を不活性ガスとすることにより、粉末焼結材料の酸化や腐食を防止するとともに、レーザ光照射による成形体の過熱による変形を防止することができる。
<Laser light>
There is no particular limitation on the laser beam used in the method of the present invention, and examples thereof include a CO 2 laser, a YAG laser, an excimer laser, a He—Cd laser, and a semiconductor excitation solid laser. Among these, the CO 2 laser is particularly suitable because it is easy to operate and easy to control. These lasers can be used alone or in combination of two or more. Depending on the type of laser used, the manufacturing time, the degree of bonding of the powdered sintered material, the porosity of the resulting artificial bone model, etc. can be adjusted.
In the method of the present invention, the atmosphere when the powder sintered material is irradiated with laser light is not particularly limited, and can be, for example, in a gas such as hydrogen, helium, argon, nitrogen, or in the atmosphere. You can also. By making the atmosphere an inert gas, oxidation and corrosion of the powder sintered material can be prevented, and deformation due to overheating of the molded body due to laser light irradiation can be prevented.
（各分割人工骨モデルの作製方法）
本発明の人工骨モデルの作製方法においては、各分割自然骨の人工骨モデルを、別々に下記のようにして作製する。
前述した粉末焼結材料を薄層状に展開し、薄層状に展開した１層分の粉末焼結材料に、各分割自然骨の断層撮影情報に基づく外観形状及び内部構造形状をレーザ光により照射して、薄層状に展開した１層分の粉末焼結材料の該レーザ光の照射部分を焼結し、さらに、１層分の粉末焼結材料の薄層状の展開と、自然骨の断層撮影情報に基づく外観形状及び内部構造形状をレーザ光により照射して薄層状に展開した１層分の粉末焼結材料の焼結とを反復して繰り返すことにより、各分割自然骨の外観形状と内部構造形状を三次元的に複製した各部分の人工骨モデルを別々に製造する。この際、積層ピッチは、通常０.０３〜０.２ｍｍ程度である。
(Production method for each artificial bone model)
In the method for producing an artificial bone model of the present invention, artificial bone models of each divided natural bone are separately produced as follows.
The powder sintered material described above is developed into a thin layer, and the appearance shape and the internal structure shape based on the tomographic information of each divided natural bone are irradiated to the powder sintered material for one layer developed into a thin layer with a laser beam. Then, the portion irradiated with the laser light of the powder sintered material for one layer developed in a thin layer is sintered, and further, the thin layer development of the powder sintered material for one layer and tomography information of natural bone The appearance shape and internal structure of each divided natural bone are repeatedly obtained by repeatedly repeating the sintering of one layer of powder sintered material that is developed into a thin layer by irradiating the appearance shape and internal structure shape based on An artificial bone model of each part whose shape is three-dimensionally replicated is manufactured separately. At this time, the stacking pitch is usually about 0.03 to 0.2 mm.
［自然骨と酷似した切削性を有する人工骨モデルの作製］
前述のようにして得られた、各分割人工骨モデルの分割面に露出している開口から、焼結していない粉末を、該人工骨モデルを振るなどして除去してから、全ての各分割人工骨モデルを、分割面で接着剤により接着して一体化することにより、自然骨と酷似した切削性を有する人工骨モデルが得られる。
前記接着剤については、各分割人工骨モデルを密着性よく接合し得る材料であれば、無機系接着剤及び有機系接着剤のいずれも用いることができる。
また、各分割人工骨モデルの分割面に露出している開口から焼結していない粉末を除去してから、除去された空孔の内面を、解剖学的重要部位を示すなどの目的で着色することができる。
[Production of artificial bone model with cutting ability very similar to natural bone]
After removing the unsintered powder by shaking the artificial bone model from the openings exposed on the dividing surface of each divided artificial bone model obtained as described above, By integrating the divided artificial bone model by bonding with an adhesive on the divided surface, an artificial bone model having cutting ability very similar to natural bone can be obtained.
As for the adhesive, both inorganic adhesives and organic adhesives can be used as long as they can join the divided artificial bone models with good adhesion.
In addition, after removing the unsintered powder from the openings exposed on the split surface of each split artificial bone model, the inner surface of the removed holes is colored for the purpose of indicating important anatomical sites. can do.
本発明の方法で製造された人工骨モデルは、自然骨と酷似した切削性を有するのみならず、内部空間構造を空間として再現し、かつ解剖学的重要部位が着色してあり、しかも手術手技の教育訓練や、術前治療計画の検討などで削開を行う場合、各分割人工骨モデルの接合面で削開を行うことで、未焼結の粉末が出ることがなく、かつ着色された重要部位も確認できることから、手術・手技の教育訓練用として、あるいは術前治療計画の検討用などとして有用である。 The artificial bone model manufactured by the method of the present invention not only has a cutting ability very similar to that of natural bone, but also reproduces the internal space structure as a space, and anatomically important parts are colored. When cutting in training and studying preoperative treatment plans, etc., the unsintered powder was not produced and colored by cutting at the joint surface of each divided artificial bone model Since important parts can be confirmed, it is useful for education and training of surgery and procedures, or for studying preoperative treatment plans.
次に、本発明を実施例により、さらに詳細に説明するが、本発明は、この例によってなんら限定されるものではない。
実施例１
成人男子の側頭骨を、Ｘ線コンピュータ断層撮影して得られた３次元ＣＡＤデータを、所定の分割面によって２つに分割して、各分割側頭骨の３次元ＣＡＤデータを得たのち、該３次元ＣＡＤデータに基づいて得られた各分割側頭骨の断層撮影情報を、ソフトウェア［Materialise社、Mimics］を用いて造形用データに変換した。このデータを造形装置に入力し、積層ピッチ０.１０ｍｍで粉末焼結材料を逐次積層焼結し、各分割側頭骨の人工骨モデルを別々に作製した。
なお、粉末焼結材料として、平均粒径５８μｍの球状のナイロン１１の粉末７０質量％と、平均粒径６０μｍのガラスビーズ３０質量％の混合物を用い、造形装置として、１００Ｗ炭酸ガスレーザを備えた粉末焼結積層造形装置［3D Systems社、Vanguard HS］を用いた。
次に、上記のようにして得られた２つの分割側頭骨の人工骨モデルを振って、分割面に露出している開口から、焼結していない粉末を除去した。
図１は、接合前の２つの分割側頭骨の人工骨モデルの斜視図である。
次に、上記２つの分割側頭骨の人工骨モデルを、分割面でシアノアクリレート系接着剤で接着して、一体化し、ヒト側頭骨の人工骨モデルを得た。
図２に、一体化されたヒト側頭骨の人工骨モデルの斜視図を示す。図２（ａ）は上面から見た斜視図、図２（ｂ）は側面から見た斜視図、図２（ｃ）は下面から見た斜視図である。なお、符号Ａは重要部位を示す黄色着色部である。
EXAMPLES Next, although an Example demonstrates this invention further in detail, this invention is not limited at all by this example.
Example 1
After the 3D CAD data obtained by X-ray computed tomography of the adult male temporal bone is divided into two by a predetermined dividing plane, the 3D CAD data of each divided temporal bone is obtained. The tomographic information of each divided temporal bone obtained based on the three-dimensional CAD data was converted into modeling data using software [Materialise, Mimics]. This data was input into the modeling apparatus, and the powder sintered material was sequentially laminated and sintered at a lamination pitch of 0.10 mm, and artificial bone models of each divided temporal bone were separately produced.
A powder comprising a spherical nylon 11 powder of 70% by mass with an average particle size of 58 μm as a powder sintering material and 30% by mass of glass beads with an average particle size of 60 μm, and a powder equipped with a 100 W carbon dioxide laser as a modeling apparatus. A sintered additive manufacturing apparatus [3D Systems, Vanguard HS] was used.
Next, the two divided temporal bone artificial bone models obtained as described above were shaken to remove the unsintered powder from the openings exposed on the divided surfaces.
FIG. 1 is a perspective view of an artificial bone model of two divided temporal bones before joining.
Next, the above-mentioned two divided temporal bone artificial bone models were bonded and integrated with a cyanoacrylate adhesive on the divided surface to obtain a human temporal bone artificial bone model.
FIG. 2 is a perspective view of an integrated human temporal bone artificial bone model. 2A is a perspective view seen from the top surface, FIG. 2B is a perspective view seen from the side surface, and FIG. 2C is a perspective view seen from the bottom surface. In addition, the code | symbol A is a yellow coloring part which shows an important site | part.
実施例２
実施例１と同様にして、２つに分割された、ヒトの側頭骨の人工骨モデルを作製したのち、それぞれ該人工骨モデルを振って、分割面に露出している開口から、焼結していない粉末を除去した。
次いで、出来上がった側頭骨の人工骨モデルの２つの部位の内部構造をそれぞれ、顔面神経管については黄色の合成着色料で、そして内耳（蝸牛、前庭、半規管）については、赤色の合成着色料にて着色した。
図３は、２つに分割され、重要部位が着色された側頭骨の人工骨モデルの斜視図である（図３（ａ）及び図３（ｂ））。
次に、上記の分割された側頭骨の人工骨モデル図３（ｂ）を反転させて、その分割面と、上記の分割された側頭骨の人工骨モデル図３（ａ）図の分割面とを、シアノアクリレート系接着剤により接着して一体化し、ヒト側頭骨の人工骨モデルを得た。
なお、図３（ａ）及び図３（ｂ）において、符号Ａ及びＢは、それぞれ黄色着色部及び赤色着色部である。
Example 2
In the same manner as in Example 1, after producing an artificial bone model of a human temporal bone divided into two, each artificial bone model was shaken and sintered from the opening exposed on the divided surface. Not powder was removed.
The internal structure of the two parts of the resulting temporal bone artificial bone model is then converted to the yellow synthetic colorant for the facial nerve tube and the red synthetic colorant for the inner ear (cochlea, vestibule, semicircular canal), respectively. And colored.
FIG. 3 is a perspective view of an artificial bone model of a temporal bone that has been divided into two and colored important parts (FIGS. 3A and 3B).
Next, the above-mentioned divided temporal bone artificial bone model FIG. 3B is inverted, and the divided surface and the divided temporal bone artificial bone model shown in FIG. Were bonded and integrated with a cyanoacrylate adhesive to obtain a human temporal bone artificial bone model.
In FIGS. 3A and 3B, symbols A and B are a yellow colored portion and a red colored portion, respectively.
本発明の方法で製造された人工骨モデルは、自然骨に酷似した切削性を有する人工骨モデルであって、手術・手技の教育訓練用として、あるいは術前治療計画の検討用などとして用いられる。 The artificial bone model manufactured by the method of the present invention is an artificial bone model having cutting ability similar to that of natural bone, and is used for education and training of surgery / procedures or for examination of preoperative treatment plans. .
Ａ 黄色着色部
Ｂ 赤色着色部
A Yellow colored part B Red colored part
Claims (5)
各分割自然骨の人工骨モデルを別々に製造するに当たり、合成樹脂粉末３０〜９０質量％と無機充填剤１０〜７０質量％からなる粉末焼結材料を薄層状に展開し、薄層状に展開した１層分の粉末焼結材料に、各分割自然骨の断層撮影情報に基づく外観形状及び内部構造形状をレーザ光により照射して、薄層状に展開した１層分の粉末焼結材料の該レーザ光の照射部分を焼結し、さらに、１層分の粉末焼結材料の薄層状の展開と、自然骨の断層撮影情報に基づく外観形状及び内部構造形状をレーザ光により照射して薄層状に展開した１層分の粉末焼結材料の焼結とを反復して繰り返すことにより、各分割自然骨の外観形状と内部構造形状を三次元的に複製した各部分の人工骨モデルを別々に製造し、各分割人工骨モデルの分割面に露出している開口から焼結していない粉末を除去してから、全ての各分割人工骨モデルを分割面で接着して一体的人工骨モデルを形成することを特徴とする自然骨と酷似した切削性を有する人工骨モデルの製造方法。 Three-dimensional CAD data of natural bone is divided into two or more by a predetermined dividing plane, three-dimensional CAD data of each divided natural bone is obtained, and tomography of each divided natural bone obtained based on the three-dimensional CAD data Based on the information, a method for producing a natural bone artificial bone model in which an artificial bone model of each divided natural bone is manufactured separately and then bonded to each divided natural bone artificial bone model,
In separately producing artificial bone models of each divided natural bone, a powder sintered material composed of 30 to 90% by mass of a synthetic resin powder and 10 to 70% by mass of an inorganic filler was developed into a thin layer and developed into a thin layer. The laser of the powder sintered material for one layer developed in a thin layer by irradiating the powder sintered material for one layer with the laser beam on the appearance shape and internal structure shape based on the tomographic information of each divided natural bone Sinter the irradiated part of the light, and further develop a thin layer of powder sintering material for one layer and irradiate the external shape and internal structure shape based on tomography information of natural bone with laser light into a thin layer By repeatedly repeating the sintering of the expanded powder sintering material for one layer, the artificial bone model of each part that replicates the appearance shape and internal structure shape of each divided natural bone three-dimensionally is manufactured separately. And exposed on the split surface of each split artificial bone model After removing unsintered powder from the mouth, all the divided artificial bone models are bonded at the dividing surface to form an integral artificial bone model, which has a cutting ability very similar to natural bone A method for manufacturing an artificial bone model.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010115447A JP5215350B2 (en) | 2010-05-19 | 2010-05-19 | Manufacturing method of artificial bone model having cutting ability very similar to natural bone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010115447A JP5215350B2 (en) | 2010-05-19 | 2010-05-19 | Manufacturing method of artificial bone model having cutting ability very similar to natural bone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011242649A JP2011242649A (en) | 2011-12-01 |
| JP5215350B2 true JP5215350B2 (en) | 2013-06-19 |
Family
ID=45409344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010115447A Active JP5215350B2 (en) | 2010-05-19 | 2010-05-19 | Manufacturing method of artificial bone model having cutting ability very similar to natural bone |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5215350B2 (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ894300A0 (en) * | 2000-07-24 | 2000-08-17 | Commonwealth Of Australia, The | A surrogate |
| JP2003070816A (en) * | 2001-08-30 | 2003-03-11 | Pentax Corp | Designing method for implant, and implant |
| JP3927487B2 (en) * | 2002-12-02 | 2007-06-06 | 株式会社大野興業 | Manufacturing method of artificial bone model |
-
2010
- 2010-05-19 JP JP2010115447A patent/JP5215350B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011242649A (en) | 2011-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3927487B2 (en) | Manufacturing method of artificial bone model | |
| Jin et al. | 3D printing of physical organ models: recent developments and challenges | |
| Negi et al. | Basics and applications of rapid prototyping medical models | |
| Jardini et al. | Improvement in cranioplasty: advanced prosthesis biomanufacturing | |
| Malik et al. | Three-dimensional printing in surgery: a review of current surgical applications | |
| Suzuki et al. | Rapid prototyping of temporal bone for surgical training and medical education | |
| Torres et al. | Application of rapid prototyping techniques for modelling of anatomical structures in medical training and education | |
| Thompson et al. | X-ray computed tomography and additive manufacturing in medicine: a review | |
| Wanibuchi et al. | Skull base training and education using an artificial skull model created by selective laser sintering | |
| WO2014002284A1 (en) | Bone-affixing screw template and method for producing same | |
| Daoud et al. | Establishing a point-of-care additive manufacturing workflow for clinical use | |
| Dobroś et al. | Application of 3D‐printed teeth models in teaching dentistry students: a scoping review | |
| Patel et al. | Medical 3D printing using desktop inverted vat photopolymerization: Background, clinical applications, and challenges | |
| Hadad et al. | The impact of 3D printing on oral and maxillofacial surgery | |
| Wersényi et al. | Cost-effective 3D scanning and printing technologies for outer ear reconstruction: Current status | |
| JP5215350B2 (en) | Manufacturing method of artificial bone model having cutting ability very similar to natural bone | |
| KR100469086B1 (en) | Device for making models of 3 dimensional bone tissue or soft tissue and application method and model thereof | |
| Malyala et al. | Manufacturing of patient specific AM medical models for complex surgeries | |
| Kashapov et al. | The application of additive technologies in creation a medical simulator-trainer of the human head operating field | |
| Suzuki et al. | Rapidly prototyped temporal bone model for otological education | |
| AU2021101703A4 (en) | 3d printing of cost-effective human skull models and skull implants | |
| Brennan | Production of anatomical models from CT scan data | |
| Mian et al. | Three‐dimensional printing in oral and maxillofacial surgery: Current landscape and future directions | |
| Gandapur et al. | Orthopaedics and additive manufacturing: The start of a new era | |
| Dincă et al. | Additive manufacturing in maxillofacial reconstruction |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20121031 |
|
| A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20121031 |
|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20121031 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20121101 |
|
| A975 | Report on accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A971005 Effective date: 20121227 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130205 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130228 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5215350 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20160308 Year of fee payment: 3 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |