JP5117550B2 - Information processing system using base sequence related information - Google Patents

Description

  The present invention relates to an information processing system that provides information via, for example, a communication network.

  Currently, genome base sequences of various organisms including humans are rapidly determined, and genome base sequence information is accumulated in various databases. For example, a system that allows various research institutions and researchers to use genome base sequence information stored in a database via an information communication network such as the Internet is being constructed.

  At the same time, research on genomic drug discovery and analysis of genetic information are being actively conducted using the base sequences included in such genomic base sequence information. Differences in the base sequence are attracting attention. In general, the difference in the base sequence between individuals is a polymorphism that is defined as having a predetermined base difference at a frequency of 1% or more in the individual species, and a predetermined base difference is less than 1% in the individual species. Means variation. In particular, a single nucleotide polymorphism (SNP: Single Nucleotide Polymorphism), which is a single base difference between individuals, is deleted or inserted into a polymorphism. Insertion / deletion polymorphism, VNTR (Variable Number of Tandem Repeat) or microsatellite polymorphism (repetition sequence is about 2 to 4 bases) with different number of repeats of sequences consisting of 2 to several tens of bases as one unit )It has been known.

  Such polymorphisms may affect differences in protein amino acid sequences between individuals, differences in expression efficiency of a given gene between individuals, and the like.

  Due to such influence, it is known that, for example, the morbidity possibility with respect to a predetermined disease varies among individuals, and the sensitivity to a predetermined drug varies among individuals.

  However, at present, no system has been constructed that effectively uses the difference in base sequence information among individuals such as polymorphisms to provide useful semantic information for each individual.

  Therefore, in view of such a current situation, the present invention can provide useful semantic information for each individual and / or information related to the semantic information by effectively utilizing the difference in the base sequence information between the individual, and is safe. The purpose is to build a highly efficient information processing system.

  The information processing system related to the base sequence according to the present invention that achieves the above-described object is intended to indicate position information that indicates a position in the base sequence, base sequence-related information associated with the position information, and the base sequence-related information. An information providing organization having a storage device storing semantic information and / or information related to the semantic information, a terminal on the user side that sends request information on goods and / or services to the information providing organization, and information And a third party checking organization having a management storage device that stores part or all of the information stored in the storage device of the providing organization. The third party checking organization includes base sequence related information sent from the user side terminal to the information providing organization and semantic information sent from the information providing organization to the user side terminal and / or information related to the semantic information, The consistency between the base sequence related information and the semantic information and / or information related to the semantic information stored in the management storage device is determined.

  In addition, the information processing system related to the base sequence according to the present invention includes position information indicating a position in the base sequence, base sequence related information associated with the position information, semantic information indicating the base sequence related information, and / or Alternatively, an information providing institution having a storage device that stores information related to the semantic information and a user terminal that sends request information on goods and / or services to the information providing institution are provided. The information provider should provide the user terminal with the consent to provide the base sequence related information and / or the consent of the semantic information and / or the content of the information related to the semantic information. Position information associated with the sequence related information is transmitted in advance. The terminal on the user side, when there is a match between the position information received in advance from the information providing organization and the location information requested to provide base sequence related information from the information providing organization, Send related information.

  Further, the information processing system related to the base sequence according to the present invention includes position information indicating a position in the base sequence, base sequence related information associated with the position information, semantic information indicating the base sequence related information, and / or Or an information providing organization having a storage device storing information related to the semantic information, and a storage device for suitability determination storing a combination of semantic information and suitability determination information, and an information providing organization And a user terminal that sends out request information for goods and / or services. The user side terminal sends base sequence related information and information about other individuals to the information providing organization. The information providing organization searches the storage device based on the base sequence related information sent from the user side terminal to obtain semantic information, and the acquired semantic information and information about other individuals sent from the user side terminal Based on the above, the suitability determination storage device is searched to acquire the suitability determination information.

  The information processing system and information processing method related to the base sequence according to the present invention can be realized as a program that causes a computer including hardware such as a control device, a transmission / reception device, and a storage device to execute each step. The information processing method related to the base sequence according to the present invention can also be realized as a recording medium recording a program that causes a computer including hardware such as a control device, a transmission / reception device, and a storage device to execute each step. Furthermore, the information processing method related to the base sequence according to the present invention can also be realized as an information processing device including hardware such as a control device, a transmission / reception device, and a storage device that execute each step.

  According to the present invention, it is possible to provide semantic information useful for each individual and / or information related to the semantic information by effectively using the difference in base sequence information between individuals, and to provide a highly safe information processing system. Can be built.

It is a schematic block diagram which shows roughly the structure of the information processing system to which this invention is applied. It is a schematic block diagram which shows the structure of a shared computer roughly. It is a block diagram which shows an example of the data recorded on main DB in 1st Embodiment. It is a schematic block diagram which shows schematically the structure of a personal computer. It is a block diagram which shows an example of the data recorded on the genome related information recording medium. It is a block diagram which shows an example of the data recorded on the management database. It is a flowchart which shows the process in a shared computer and a personal computer in the system which provides the morbidity possibility with respect to a predetermined disease. FIG. 8 is a continuation of FIG. 7 and is a flowchart showing processing in a shared computer and a personal computer in a system for providing a morbidity possibility for a predetermined disease. It is a flowchart which shows the process in a 3rd party check organization. It is a block diagram which shows an example of the data recorded on main DB used in the system for providing the chemical | medical agent according to the constitution in 2nd Embodiment. It is a flowchart which shows the process in a shared computer and a personal computer in the system which provides the chemical | medical agent according to a constitution. FIG. 12 is a continuation of FIG. 11 and is a flowchart showing processing in a shared computer and a personal computer in a system for providing a drug according to a constitution. It is a screen image shown as an example of a tailor maid popular medicine portal screen. It is a screen image shown as an example of a medicine type menu screen. It is a screen image shown as an example of an individual IC confirmation input screen. It is a screen image shown as an example of a confirmation screen. It is a block diagram which shows an example of the data recorded on main DB in 3rd Embodiment. It is a block diagram which shows an example of the data recorded on the suitability determination database. It is a block diagram which shows an example of the data recorded on the genome relevant-information recording medium in 3rd Embodiment. It is a flowchart which shows the process in a shared computer and a personal computer in the system which provides a user with the compatibility determination information with another individual | organism | solid. FIG. 21 is a continuation of FIG. 20 and is a flowchart showing processing in a shared computer and a personal computer in a system for providing compatibility determination information with another individual to a user. It is a block diagram which shows an example of the table produced in the memory part in a shared computer. It is a block diagram which shows an example of the table produced in the memory part in a personal computer.

Hereinafter, the present invention will be described in detail with reference to the drawings.
<First Embodiment>
First, as a first embodiment to which the present invention is applied, there is an information processing system that provides a user with the possibility of suffering from a predetermined disease, which is illegal use of the system, particularly, illegal base sequence related information. An information processing system having a third party checking organization that verifies use / collection and semantic information and / or illegal provision of information related to the semantic information will be described. That is, a case will be described in which the user requests that he / she wants to know his / her morbidity regarding a predetermined disease, for example, as a “request for goods and / or services”. In particular, in the present embodiment, an information processing system that can recognize unauthorized use / collection of base sequence related information and improper provision of semantic information and / or information related to the semantic information will be described. This will be described as a simplified model. Note that “goods and / or services” are not limited to this, and are suitable for, for example, articles such as pharmaceuticals, foods and luxury goods suitable for an individual (individual) constitution, and an individual (individual) constitution / property. It means to include services such as information.

  As shown in FIG. 1, the information processing system includes a communication network 1 such as the Internet, a shared computer 2 connected to the communication network 1, a plurality of personal computers 3 connected to the communication network 1, A third party check institution C connected to the communication line network 1, and enables data communication among the shared computer 2, the personal computer 3, and the third party check institution C via the communication line network 1. .

  As shown in FIG. 2, the shared computer 2 includes a CPU 4 that controls all operations of the shared computer 2, an input device 5 such as a keyboard and mouse that can input information and program execution instructions, and a display device and the like. Device 6, memory 7 for recording temporary information and non-rewritable information, database 8 for storing various data, and recording device for writing predetermined information in memory 7 and database 8 9 and a transmission / reception device 17 that transmits / receives information to / from the personal computer 3 and the third party check organization C via the communication line network 1.

  The memory 7 in the shared computer 2 includes a memory unit A10 and a memory unit B11 that record different types of information, a screen memory 12 that records image data to be displayed on the personal computer 3 or the display device 6, for example, and this system. And a processing program 13 for operating. In the shared computer 2, the screen memory 12 and the processing program 13 are not included in the internal memory 7 but are stored in an external recording device (not shown) connected to the shared computer 2 via the communication line network 1. It may be a thing.

  The database 8 (storage device) in the shared computer 2 includes a main DB 14 in which a multi-model area, a polymorphic pattern, and semantic information are recorded, a storage DB-A 15 that stores information recorded in the memory unit A10, and a memory unit. It consists of a storage DB-B16 that stores the information recorded in B11. As shown in FIG. 3, the main DB 14 records a polymorphism address, a plurality of polymorphic patterns that can be taken in the polymorphism area, and semantic information that means each of the polymorphism patterns in association with each other. Yes.

  The main DB 14 may record semantic information meaning a combination of polymorphic patterns (for example, haplotypes) in a plurality of multimodel numbers.

  Here, “multi-model number location (position information)” means at least a position where a polymorphism exists in the base sequence. In general, polymorphism includes, for example, so-called SNP (single nucleotide polymorphism), RFLP (restriction fragment length of polymorphism), VNTR (variable number of tandem repeat), microsatellite, and the like. However, the “polymorphism” used in the present specification is not limited to these, and includes a base and a change (variation) in the base sequence that are present in the individual species with a frequency of less than 1%. Therefore, “multi-model address” means to include a position in a base sequence that indicates a change in base and base sequence that exists only at a frequency of less than 1% in an individual species. That is, the “multi-model number place” represents a position indicating a polymorphism or the like by combining numerical values, characters, symbols, and the like. The polymorphism location is not particularly limited. For example, the polymorphism can be represented by a combination of a chromosome number and a symbol representing a gene in which the polymorphism exists and a numerical value indicating the location of the polymorphism in the gene. A combination of a symbol indicating an existing gene and a numerical value indicating the position of polymorphism in the gene may be used.

  The polymorphism number may be a polymorphic notation assigned to each polymorphism. When a polymorphism-specific notation is used as the polymorphism location, the polymorphism location does not directly indicate the position in the base sequence, but the position can be indirectly known based on the polymorphism-specific notation. Therefore, “multi-model number place” means to include notation unique to the polymorphism.

  “Polymorphism pattern (base sequence related information)” is information on a base sequence that differs between individuals, and means that it includes at least a base or base sequence pattern in the polymorphism. Furthermore, the “polymorphism pattern” is not limited to polymorphism, and includes a pattern of bases and base sequences that are present only at a frequency of less than 1% in individual species. For example, in a polymorphism area that is known to take A or G, the “polymorphism pattern” is represented by either “A” or “G”.

  Further, the “polymorphic pattern” may indicate a heterozygote or a homozygote in a homologous chromosome. In this case, for example, in a multi-model area that is known to take A or G, the “polymorphic pattern” can be expressed by any one of “AA”, “GG”, and “AG”.

  Furthermore, the “polymorphic pattern” does not directly represent a pattern that can be taken in a predetermined polymorphism area, but may indirectly represent it. That is, the “polymorphic pattern” is, for example, “allele 1” when taking “A” in a polymorphism area known to take A or G, and “allele 2” when taking “G”. May be written. Further, when the “polymorphic pattern” can be expressed by any of “AA”, “GG”, and “AG” as described above, for example, when it can be expressed by “AA”, it can be expressed by “α”, “GG”. When it can be expressed as “β”, when it can be expressed as “AG”, it may be expressed as “γ”. By the way, in the present system, the polymorphic pattern may be encrypted or not encrypted.

  Other notation examples of “polymorphism pattern” are numerical values representing “repeat number” when the polymorphism is a microsatellite, and “present / absent” symbol when the polymorphism is an insertion or deletion type. It may be written as Furthermore, the “polymorphism pattern” in each polymorphism area may be described as, for example, “polymorphism 1”, “polymorphism 2”, or “polymorphism 3” according to a predetermined rule or agreement. For example, “polymorphism 1”, “polymorphism 2”, and “polymorphism 3” can be written in descending order of the frequency that the “polymorphism pattern” can take in each polymorphism area. In this case, for example, each “polymorph 1” in each multi-model number area does not necessarily represent the same content. That is, for example, “polymorph 1” of a certain model number indicates “AA” having the highest frequency, and another “model 1” indicates “GG” having the highest frequency. become.

  Here, the “semantic information” is information associated with the “polymorphism pattern”, and is based on, for example, responsiveness to drugs, side effects on drugs, risks to diseases and disorders, constitutions / properties, constitutions / properties, etc. It means various information resulting from differences in "polymorphic patterns" such as lifestyle advice and protein interactions. The “semantic information” may directly represent various information resulting from the difference in the “polymorphic pattern”, or may be indirectly represented using a symbol or the like meaning the information. The “semantic information” is information of a type that is corrected as the number of types increases as research on the genome / gene progresses, and it is preferable to always upgrade the version. In other words, the “semantic information” becomes more accurate by updating / accumulating the database using the research results of the genome / genes, thereby increasing / decreasing the accumulated amount.

  Information that is not directly related to the “polymorphic pattern” but is further derived from the “semantic information” is “information related to the semantic information”. When the “semantic information” is “risk for a disease”, when the risk exceeds a certain level, for example, a specific “health checkup item” is derived. This specific “health examination item” is “information related to semantic information”.

  In this embodiment, as shown in FIG. 3, semantic information is recorded in the main DB 14 as “annotation information for a polymorphic pattern” associated with at least a predetermined “polymorphic pattern area” and “polymorphic pattern”. Yes. The semantic information is associated with “polymorphic classification” and “classification (disease name)” corresponding to a predetermined “multi-model number location”. That is, when the predetermined “multi-model number” is a predetermined “polymorphic pattern”, it is possible to obtain annotation information (semantic information) indicating the type of disease name and the morbidity of the disease. Therefore, for example, the semantic information can be associated with a combination (for example, haplotype) of each polymorphic pattern corresponding to a plurality of polymorphism addresses. That is, annotation information (semantic information) indicating different morbidity with respect to a predetermined disease can be associated with each combination of polymorphic patterns in a plurality of polymorphism locations. In this case, when a plurality of multi-model numbers are a combination of predetermined polymorphic patterns, annotation information (semantic information) indicating the possibility of suffering from a predetermined disease can be obtained.

  Further, the “publication level” determined by a predetermined standard can be associated with the semantic information. For example, the criteria for determining the “publication level” should be determined in consideration of unforeseen disadvantages to individuals due to the disclosure of the semantic information, that is, here the possibility of “classification (disease name)”. Can do. Specifically, in the shared computer 2, in accordance with laws, rules, own behavior standards, or contracts with users, etc., a “publication level” is determined so that semantic information that is not appropriate to be disclosed is not disclosed. be able to. In this case, in the present system, the annotation information indicating the possibility of morbidity associated with the “public level” meaning that the information cannot be disclosed is not disclosed to the user. As a result, it is possible to prevent the user from being given semantic information that can be an unexpected disadvantage, and to prevent the semantic information from being disclosed to anyone other than the contractor.

  In addition, as shown in FIG. 3, information related to the information source of the semantic information is associated with the semantic information as “information source”. This “information source” indicates the source of the semantic information such as the organization that created the semantic information and the organization that provided the semantic information to the shared computer 2. By associating the “information source” with the semantic information, the credibility of the semantic information can be determined.

  In the database 8, for example, data such as base sequence related information that is genetic information of the individual requester who uses this system can be recorded in the storage DB-B 16. The storage DB-A 15 can record data such as information for specifying a requester who uses the system. In this way, by storing the individual genetic information and the information for specifying the individual separately in the storage DB-A 15 and the storage DB-B 16, the genetic information of the requester and the data for specifying the requester It becomes difficult to relate.

  The shared computer 2 is not limited to the one having the database 8 therein, and may have an external database (not shown) connected to the shared computer 2 via the communication line network 1. The shared computer 2 may have a plurality of databases 8 inside, or may have an internal database 8 and an external database connected to the shared computer 2 via the communication line network 1. May be.

  As shown in FIG. 4, the personal computer 3 includes a CPU 20 that controls all operations of the personal computer 3, an input device 21 such as a keyboard and a mouse that can input information and program execution instructions, a display device, and the like. Display device 22, a memory 23 in which temporary information and rewritable information are recorded, a reading device 25 that reads data from the genome-related information recording medium 24, a shared computer 2 and It is comprised from the transmission / reception apparatus 29 which transmits / receives information between the 3rd party check organizations C. The personal computer 3 is not limited to a normal computer, and may be in any form such as a mobile phone, a personal mobile terminal, and other mobile communication devices.

  The memory 23 in the personal computer 3 has a memory unit 26 for recording information from the genome related information recording medium 24, and a processing program 27 for operating the information processing system is recorded therein.

  In the genome related information recording medium 24, individual genome related information 28 is recorded. Examples of the genome-related information recording medium 24 include a magnetic recording medium such as a magnetic disk and a magnetic card, an optical recording medium to which a magneto-optical recording method, a phase change recording method, and the like are applied, and a semiconductor memory. The genome-related information recording medium 24 may be in any form such as card, disk, stick, tape, or drum. Further, the genome-related information recording medium 24 may be one that records genome-related information 28 of a single individual (individual), but records a plurality of genome-related information 28 related to a plurality of individuals (individuals). It may be a thing.

  The genome-related information 28 included in the genome-related information recording medium 24 includes at least a “polymorphism pattern” in a predetermined multi-model area obtained as a result of analyzing the base sequence of the “multi-model area” and an individual (individual). means. In addition, the genome-related information 28 may include various types of information such as past illness, characteristics, medical record information, and health checkup results.

  In the genome-related information recording medium 24, for example, as shown in FIG. 5, the individual number “Gno.” (G number) unique to the genome-related information 28 and the date of birth, etc. The personal information is recorded, the multi-model area and the polymorphic pattern are recorded as data II, the past disease is recorded as data III, the characteristics are recorded as data IV, and the medical record information and the like are recorded as data V. That is, the genome related information 28 includes data I, data II, data III, data IV, and data V. Data I and data II contain essential information, and data III, data IV and data V are composed of additional information.

  In the genome related information 28, the “multi-model number location” corresponding to the position on the base sequence and the “polymorphism pattern” in the multi-model location are linked and recorded. Further, in the data II, additional information in a predetermined multi-model number address may be recorded as a “comment” linked to the “multi-model number address”. Data II may record the entire base sequence related to a predetermined individual. Even when the entire base sequence is recorded in the data II, the “polymorphic pattern” and the “polymorphic pattern” are included in the data II.

  In the present invention, the personal computer 3 and the genome-related information recording medium 24 are not limited to the configurations shown in FIGS. 4 and 5, respectively. For example, the memory section in which the genome-related information recording medium has a processing program. The personal computer may be configured to operate the processing program by mounting the genome-related information recording medium. In this case, the personal computer can operate according to the processing program recorded in the memory section of the genome related information recording medium.

  On the other hand, as shown in FIG. 6, the third party checking organization C obtains the polymorphism area, polymorphism pattern and semantic information and / or information related to the semantic information stored in the main DB 14 for each shared computer 2. The management database 30 (management storage device) is stored together with the unique identifier. When there are a plurality of shared computers 2 in this system, the management database 30 stores an identifier, a multi-model address, a polymorphic pattern, and semantic information for each shared computer 2. The third party checking organization C is not limited to having the management database 30 inside, but may have the management database 30 outside that can be connected via the communication line network 1.

  In this system, it is preferable that the organization having the shared computer 2 is obliged to disclose the main DB 14 to the third party checking organization C before conducting business. In other words, the third party checking organization C participates in this system only for the shared computer 2 that is judged to be suitable for conducting a sound business as a result of checking the main DB 14 among the shared computers 2 that disclosed the main DB 14. It is preferable to give authority. In addition to the method in which the main DB 14 is inspected by a third party check organization, if the inspection itself is conducted by, for example, an administrative institution and the result of the inspection determines that it is suitable for conducting the business, the main DB 14 is inspected by a third party. The method disclosed in the check organization C may be used.

  Further, when the shared computer 2 has a database storing “information related to semantic information” separately from the main DB 14, it is preferable to require the third party checking organization C to disclose the database. .

  In the information processing system configured as described above, the processing program 13 recorded in the memory 7 of the shared computer 2 and the processing program 27 recorded in the memory 23 of the personal computer 3 are shown in FIGS. Information processing operation is performed according to the flowchart as shown. In the flowcharts shown in FIG. 7 and FIG. 8, a step described as “(co)” means a process in the shared computer 2, and a step described as “(piece)” means a process in the personal computer 3. ing. Further, in the information processing system, the processing program recorded in the memory of the third party checking organization C performs information processing according to a flowchart as shown in FIG.

  In this information processing system, each individual who has the genome-related information recording medium 24 accesses the shared computer 2 through the communication network 1 using the personal computer 3 and is recorded in the main DB 14 of the shared computer 2. It is a system that uses semantic information. The information processing system may be a system in which each individual accesses the genome-related information recording medium 24 using the genome-related information recording medium 24 in which the genome-related information 28 of a plurality of persons is recorded.

  An individual who uses this system is, for example, a person who owns the genome-related information recording medium 24. An individual who uses this system (hereinafter referred to as a requester) first activates the processing program 27 recorded in the memory 23 and drives the reading device 25 of the personal computer 3 in step A1 (SA1). The genome-related information recording medium 24 is accessed, and “Gno.” Recorded as data I in the genome-related information recording medium 24 is read out. The read “Gno.” Is stored in the memory unit 26.

  Next, in step A2 (SA2), based on the screen image displayed on the display means 22 by the processing program 27, information that the requester wants to receive, for example, “possibility of colorectal cancer” (request information) ) Is input to the personal computer 3, and “possibility of colorectal cancer” and “Gno.” Are transmitted from the personal computer 3 to the shared computer 2 via the communication network 1. Alternatively, “possibility of colorectal cancer” and “Gno.” Are written from the personal computer 3 to the shared computer 2 via the communication network 1.

  Next, in step A3 (SA3), the shared computer 2 receives “possibility of colorectal cancer” and “Gno.”. The received “possibility of colorectal cancer” and “Gno.” Are stored as request information in the memory unit A10.

  Next, in step A4 (SA4), when the request information is received, the processing program 13 recorded in the memory 7 is activated and the main DB 14 is accessed. The processing program 13 performs processing in the shared computer 2.

  Next, in step A5 (SA5), the “classification (disease name)” recorded in the main DB 14 is searched according to the processing program 13, and the requested “possibility of colorectal cancer” (colorectal cancer). That match is extracted.

  In step A6 (SA6), “multi-model address” associated with “classification (disease name)” (colorectal cancer) that matches “possibility of colorectal cancer” from the data recorded in the main DB 14 "Is read out. The read “multi-model number address” is stored in the memory unit A10 as position information associated with the request information. That is, “possibility of colorectal cancer” and “multiple model number” are recorded in the memory unit A10 for a predetermined “Gno.”.

  Next, in step A7 (SA7), “Gno.” And “multi-model address” recorded in the memory unit A10 and “identifier” for identifying the shared computer 2 are transmitted to the personal computer 3 and transmitted. Command information for submitting a “polymorphic pattern” corresponding to the “polymorphic area” is transmitted to the personal computer 3. At this time, depending on the type of request information, it may be instructed to submit additional information such as a past illness or a feature as necessary.

  Next, in step A8 (SA8), "Gno.", "Multi-model address", "identifier" and command information transmitted from the shared computer 2 are received. The received “Gno.”, “Multi-model number address”, and “identifier” are recorded in the memory unit 26.

  Next, in step A9 (SA9), the data II recorded in the genome related information recording medium 24 is accessed according to the received command information. In step A10 (SA10), the data II recorded in the genome-related information recording medium 24 is searched according to the processing program 27, the commanded polymorphism pattern of the polymorphism pattern is read, and the polymorphism pattern and polymorphism pattern are obtained. The data is recorded in the memory unit 26 in association with each other. At this time, it is preferable to access data I and confirm whether or not “Gno.” Received in step A8 is correct. In step A10, in addition to the polymorphic pattern, additional information recorded in the data III, data IV, and data V may be simultaneously read and recorded in the memory unit 26 as necessary.

  Next, in step A11 (SA11), the polymorphic pattern associated with the polymorphism number temporarily recorded in the memory unit 26 and the additional information recorded as necessary, together with "Gno." The data is output to the shared computer 2 via the network 1. In step A12 (SA12), the shared computer 2 receives the polymorphism pattern associated with the polymorphism address and additional information recorded as necessary, and associates the received polymorphism pattern with the polymorphism address and stores the information. Record in part A10.

  In this example, in step A7, the shared computer 2 sends command information for instructing the submission of the “polymorphic pattern”. In step A10, the personal computer 3 records the polymorphic pattern according to the command information in the genome related information recording. Reading from the medium 24. However, this system may be a system that does not transmit the command information in step A7. In this case, in step A10, the personal computer 3 searches the data II based on the multi-model number received in step A8 according to the processing program 27, and reads the received polymorphic pattern of the multi-model number. Then, the personal computer 3 outputs a polymorphic pattern or the like to the shared computer 2 in step A11. Even in this case, the shared computer 2 can obtain the polymorphism pattern of “multi-model area” associated with “classification (disease name)” that matches “possibility of colorectal cancer” in step A12. .

  Next, in step A13 (SA13), the main DB 14 is accessed, and a search is made for a match with the received polymorphism address and polymorphism pattern. Specifically, in the main DB 14, a plurality of polymorphism patterns are recorded for one polymorphism address, and the received polymorphism pattern and the polymorphism pattern match which polymorphism pattern in the main DB14. To find out.

  Next, in step A14 (SA14), according to the processing program 13, the morbidity possibility (semantic information) for colorectal cancer associated with the polymorphic pattern that matches the received polymorphic pattern is read. That is, in step A14, according to the multi-model number area and polymorphism pattern submitted by the requester, it is possible to read out the possibility of suffering from colon cancer of the requester. The read possibility of morbidity is stored in the memory unit A10 in association with the requester's “Gno.”, “Multi-model area”, and “polymorphic pattern”. At this time, the possibility of being affected by colorectal cancer may be stored in a form corrected by additional information, or other information obtained from the additional information is stored in association with the requester “Gno.”. You may do it.

  Next, in step A15 (SA15), the possibility of morbidity stored in the memory unit A10 and the multiple model number address used when reading the morbidity possibility from the main DB 14 are associated with each other via the communication network 1. It is transmitted to the personal computer 3 together with the requester “Gno.”. That is, in step A15, the morbidity possibility read in step A14 and the multi-model number address corresponding to the morbidity possibility are linked and transmitted as a set. In step A15, in addition to “Gno.” And the possibility of morbidity and a set of multi-model numbers corresponding to the morbidity, the “information source” recorded in the main DB 14 It may be transmitted in association with a set of multiple model numbers corresponding to morbidity. By transmitting the information source, the requester side evaluates the credibility of the morbidity possibility based on the information source, the multi-model number corresponding to the morbidity possibility, and the polymorphism pattern corresponding to the multi-model area. be able to. That is, on the requester side, in addition to the received information source, the possibility of morbidity, and the set of multi-model numbers corresponding to the possibility of morbidity, the personal computer 3 is associated with the polymorphic pattern transmitted by itself in step A11. The requester prepared the information about the morbidity by using the polymorphism pattern associated with the polymorphism area by the institution described in the information source by outputting the information on the display means 22 or on paper. In order to know this, it is possible to evaluate the reliability of the information regarding the possibility of the disease. On the information provider side, the requester side will provide a responsible service in order to evaluate the reliability.

  Next, in step A16 (SA16), the personal computer 3 receives the requester “Gno.” And the possibility of morbidity and a set of multi-model addresses corresponding to the morbidity. The received morbidity possibility and a set of multiple model numbers corresponding to the morbidity possibility are recorded in the memory unit 26.

  Next, in step A17 (SA17), according to the processing program 27, the possibility of suffering from colorectal cancer is displayed on the display means 22 from the semantic information recorded in the memory unit 26. Thereby, the requester can obtain the possibility of suffering from colorectal cancer using the genome related information 28 recorded in the genome related information recording medium 24.

  The “information related to semantic information” is further derived from the “semantic information” read in step A14, and the “information related to semantic information” is added to the “semantic information” together with the “semantic information” in step A15. Even when they are transmitted in association with the ground and received in step A16, “semantic information” and the “information related to semantic information” are displayed in step A17.

  Further, in this system, in step A3, in addition to the “possibility of afflicting colon cancer” desired by the requester, for example, when the morbidity possibility exceeds a predetermined level, “prevent colon cancer” When the provision of functional food is received as further request information, and the information regarding the possibility of afflicting the colorectal cancer of the requester is received, if the morbidity exceeds a predetermined level, the requested functional food It is also possible to provide.

  Note that steps A3 to A7 and steps A12 and steps A12 to A15 in the shared computer 2 may be performed by different institutions. In this case, the steps in the shared computer 2 are divided into two.

  On the other hand, in this system, is the third party checking organization C conducting business within the scope of the unauthorized use / collection of the polymorphic pattern by the shared computer 2 and the originally authorized business contents according to the flowchart shown in FIG. Can be verified.

  First, in step 1 (S1), an identifier for identifying the shared computer 2 from the personal computer 3, the polymorphism address transmitted to the shared computer 2, the polymorphic pattern, and the morbidity provided from the shared computer 2 ( Semantic information) is received as a set (information set).

  Next, in step 2 (S2), the management database 30 is searched based on the identifier, multi-model area, polymorphism pattern and morbidity received in step 1, and the multi-model area and polymorphism received in step 1 are searched. The coincidence between the pattern and the morbidity possibility and the information stored in the management database 30 in advance is determined. Here, the determination of coincidence is the case where the polymorphism location, polymorphism pattern and morbidity received in step 1 coincide with the information stored in the management database 30 in advance, and It is meant to include the case where they substantially match. The notation coincidence means, for example, the case where the notation regarding a predetermined position on the base sequence is the same for the multi-model numbers. The substantial match means, for example, the case where the same position in the base sequence is indicated directly or indirectly even if the multiple model numbers do not match in the notation.

  If it is determined in step 2 that the polymorphism location, polymorphism pattern and morbidity received in step 1 are consistent with the information stored in the management database 30 in advance, the shared computer 2 This means that there was no deviation from the scope of the originally authorized business, and the misuse / collection of polymorphic patterns. Accordingly, in this case, the process proceeds from step 2 to “Yes” to stop the processing.

  On the other hand, if it is determined in step 2 that the polymorphism area, polymorphism pattern and morbidity received in step 1 are not consistent with the information stored in the management database 30 in advance, the shared computer 2 This means that there is a risk of unauthorized use / collection of the polymorphic pattern and deviation from the scope of the originally authorized business. Therefore, in this case, the process proceeds from step 2 to “No”, and the process of step 3 Execute. Note that the case where the multi-model number, polymorphism pattern and morbidity received in step 1 are not consistent with the information stored in the management database 30 in advance is, for example, the multi-model number received in step 1 When there are a plurality of sets of ground, polymorphism patterns and morbidity, it means that at least one set does not match.

  Next, in step 3 (S3), in step 2, it was found that there was a risk of unauthorized use / collection of polymorphic patterns by shared computer 2 and deviation from the scope of the originally authorized business. It transmits to the computer 2. In step 3, the personal computer 3 may be notified that there has been a risk of unauthorized use / collection of the polymorphic pattern by the shared computer 2 and deviation from the scope of the originally authorized business content. .

  As described above, in this system, the personal computer 3 transmits the identifier, the multi-model number area, the polymorphism pattern, and the semantic information of the shared computer 2 to the third-party check organization C, thereby enabling the third party. It is possible to verify the possibility of unauthorized use / collection of the polymorphic pattern in the check organization C and deviation from the scope of the originally authorized business content.

  That is, according to the present system, the third party checking organization C allows the shared computer 2 to acquire the semantic information of all the polymorphic patterns associated with the polymorphic address transmitted from the personal computer 3 in step A11. It can be confirmed whether it is used or not used, and whether the meaning information and / or the contents of the information related to the meaning information are the same as the contents that passed the initial inspection. For example, in the shared computer 2, when the polymorphic pattern associated with the polymorphism number transmitted in step A11 is used for a purpose other than the request of the requester or simply collected, the use other than the original purpose is used. A three-party check organization C can be found. Also, the third party checking organization C is different from the semantic information that passed the initial examination and / or information related to the semantic information, and for example, the semantic information and / or information related to the semantic information has been altered to exaggerated content. Thus, the shared computer 2 that provides the service can be found. The shared computer 2 uses or collects polymorphic patterns associated with polymorphisms for purposes other than the original purpose of presenting the required morbidity, and / or semantic information that has passed the initial examination and / or When a business is performed with contents different from the information related to the semantic information, it cannot be concealed from the third party check organization C.

  Therefore, this system can serve as a deterrent against unauthorized use / collection of polymorphism patterns and polymorphism patterns recorded in the genome-related information recording medium 24 in the shared computer 2 and deviation from the scope of the originally authorized business. .

  In this information processing system, it is possible to use a storage medium having only the data I and additionally data III to V except the information included in the data II from the genome-related information recording medium. In this case, information included in the data II is recorded in an external database (genome related information recording medium) connected to the personal computer 3 via the communication line network 1. In the case of such a system, for example, in step A10 described above, an external database is accessed via the communication line network 1, the commanded polymorphism pattern of the polymorphism area is read, and the polymorphism area and the polymorphism pattern are read. Can be recorded in the memory unit 26 in association with each other. Therefore, even in such a system, the requester can obtain semantic information as in the flowcharts shown in FIGS.

  Further, in this information processing system, the requester does not have either the genome-related information recording medium 24 or the recording medium excluding the information included in the data II from the genome-related information recording medium, In addition, a genome-related information recording medium 24 connected to the personal computer 3 may be provided. In the case of such a system, the requester accesses the genome-related information recording medium 24 via the communication network 1 and records “multi-model number” and “polymorphic pattern” recorded in the genome-related information recording medium 24. Can be downloaded to the personal computer 3. In this case, the genome-related information recording medium 24 may record genome-related information regarding a plurality of individuals for each individual (for each “Gno.”).

  Furthermore, the present invention is not limited to the configuration in which the shared computer 2 has the main DB 14 as described above. For example, the information processing system including the main DB 14 connected to the shared computer 2 via the communication network 1. Also applies. In this case, the shared computer 2 accesses the main DB 14 via the communication network 1 in the flowcharts shown in FIGS. Even in this case, according to the information processing system, the requester can obtain desired semantic information according to the flowcharts shown in FIGS.

  In particular, in this case, the shared computer 2 accesses a plurality of main DBs 14 possessed by different organizations or organizations via the communication network 1, and uses the semantic information contained in the plurality of main DBs 14 to request the requester. It is possible to provide information for. That is, in this information processing system, the shared computer 2 accesses various main DBs 14 having information on the possibility of developing colorectal cancer as semantic information in step A4 in the flowcharts shown in FIGS. Thus, according to the information processing system, the requester can obtain information on the possibility of colorectal cancer based on information included in various main DBs 14.

  In the flowchart shown in FIGS. 7 and 8, the shared computer 2 transmits at least the request information received from the personal computer 3 to the so-called agent, and the semantic information (in this example, “Possibility of suffering from colorectal cancer”) may be obtained via the agent.

  In this system, the polymorphic pattern may be encrypted or unencrypted.

  For example, an encrypted polymorphic pattern may be received from among the encrypted polymorphic patterns associated with the polymorphism address, or the encrypted polymorphic pattern may be decrypted and then decrypted. The type pattern may be received, or the polymorphic pattern may be received after being encrypted from the unencrypted polymorphic pattern.

  Also, for example, an encrypted polymorphic pattern may be acquired and the polymorphic pattern may be transmitted in an encrypted state, or the encrypted polymorphic pattern may be acquired and decrypted before being transmitted. Alternatively, an unencrypted polymorphic pattern may be acquired and encrypted, and then the polymorphic pattern may be transmitted.

<Second Embodiment>
Next, as a second embodiment to which the present invention is applied, there is provided an information processing system for providing a drug according to a constitution such as responsiveness to a drug and immunity to a substance to a user. An information processing system capable of checking the intention of unauthorized use of the system, particularly the intention of unauthorized use / collection of base sequence related information, will be described. That is, a case where the user requests a medicine as “request for goods and / or services” will be described as an example. In particular, in the present embodiment, an information processing system capable of recognizing the intention of unauthorized use / collection of base sequence related information will be described. However, for the convenience of explanation, it will be described as a simplified model. The information processing system described as the present embodiment uses the same names, symbols, and definitions for the same configurations and terms as those of the information processing system in the first embodiment described above, so that the configurations, operations, and terms The description of is omitted.

  In the present embodiment, in particular, semantic information (medicine type) as shown in FIG. 10 is recorded in the main DB 14.

  The information processing system for providing a medicine can provide the optimum medicine to the user according to the flowcharts shown in FIGS. 11 and 12, for example. In the flowcharts shown in FIG. 11 and FIG. 12, a step described as “(co)” means a process in the shared computer 2, and a step described as “(piece)” means a process in the personal computer 3. ing.

  First, in step II-1 (SII-1), the requester (user) accesses the shared computer 2 of, for example, a pharmaceutical company from the personal computer 3 via the communication network 1. As the shared computer 2 of the pharmaceutical company, for example, a dedicated computer may be used, or a computer that manages drug ordering, ordering and shipping information may be used. It may be a computer that manages manufacturing. Note that the shared computer 2 is not limited to a computer belonging to a pharmaceutical company, and is a trader or group that provides information such as the type of drug to be provided and the number of drugs to the drug provider side of the pharmaceutical company. It may belong to.

  In this example, the requester is an individual who owns the genome-related information recording medium 24, a medical institution that owns the genome-related information recording medium 24, or a medical that uses the genome-related information recording medium 24 held by the individual. An organization etc. can be illustrated.

  Next, in Step II-2 (SII-2), in the shared computer 2, the processing program 13 is started in response to the requester's access, and the “tailor-made popular medicine portal screen” is read from the screen memory 12, and the personal computer is read. 3 on the display means 22. As the “tailor-made popular medicine portal screen”, for example, a screen image as shown in FIG. 13 can be exemplified.

  Next, in step II-3 (SII-3), the requester attaches the genome-related information recording medium 24 to the reading device 25 according to the instruction of the “tailor-made mass medicine portal screen”, and uses the personal computer 3 for genome-related information. The information recording medium 24 can be accessed. At this time, it is preferable to authenticate that the requester is an authorized user of the genome-related information recording medium 24. After that, in Step II-4 (SII-4), the requester clicks the “OK” button displayed on the “Tailor-Made Generic Drug Portal Screen” to give the shared computer 2 the intention to use this system. Send to.

  Next, in step II-5 (SII-5), the “medicine menu” screen is read from the screen memory 12 according to the processing program 13 in the shared computer 2 and displayed on the display means 22 of the personal computer 3. As the “drug type menu” screen, for example, a screen image as shown in FIG. 14 can be exemplified.

  Next, in step II-6 (SII-6), the desired drug type (drug) is selected according to the “drug type menu” screen accessed by the requester using the personal computer 3.

  Next, in Step II-7 (SII-7), the reading device 25 of the personal computer 3 accesses the genome related information recording medium 24 and reads “Gno.” From the data I. In step II-8 (SII-8), the “Gno.” Read in step II-7 and the “drug type” (request information) selected in step II-6 are transmitted via the communication network 1. Transmit to the shared computer 2.

  Next, in step II-9 (SII-9), the shared computer 2 receives “Gno.” And “drug type” and stores “Gno.” And “drug type” in the memory unit A10. By the way, in this example, “public level” is associated with the semantic information recorded in the main DB 14. The “public level” in this example indicates whether or not semantic information and information related to the semantic information should be disclosed to the side using them. Specifically, “Public Level A” indicating a level that may be disclosed only when the requester is authenticated, and any requester regardless of whether the requester is authenticated. “Public level B” indicating a level that can be disclosed to the public and “Prohibit disclosure” indicating a level that should not be disclosed to any requester are recorded in association with the semantic information. .

  Further, the shared computer 2 is a database (not shown) in which “information about a requester having authentication (for example,“ requester No. ”)” is recorded in advance in the database 8. )have.

  The requester transmits “requester No.” together with “Gno.” And request information to the shared computer 2. In the case of providing a requester with a service using the semantic information associated with “public level A” and information related to the semantic information, the shared computer 2 uses the “requester information database”. To determine whether or not the requester has authentication based on the received “requester No.”.

  As a result of the determination, if the requester has authentication, “Gno.” Received from the personal computer 3 is associated with “public level A” and registered in the memory 7. By searching for “public level” in the main DB 14 based on “A”, the requester is provided with a service using semantic information associated with “public level A” and information related to the semantic information. On the other hand, as a result of the determination, if the requester does not have authentication, the step is immediately stopped, or the received “Gno.” Is associated with “public level B” and registered in the memory 7, and the subsequent steps By searching the “public level” of the main DB 14 based on the registered “public level B”, the semantic information associated with the “public level B” to the requester and the information related to the semantic information are used. Provide service. As described above, by using the “publication level”, it is possible to determine whether disclosure of semantic information and information related to the semantic information is permitted.

  Note that this example is a system that provides a popular drug, and since the requester is an unspecified number of people who do not need to be authenticated in advance, the system determines whether the requester has authentication. There is no need. Therefore, in step II-9, the request information (drug type) is received, and “public level B” is automatically selected and registered in the memory 7 in association with “Gno.”.

  Next, in step II-10 (SII-10), the main DB 14 is accessed according to the processing program 13. In step II-11 (SII-11), the processing program 13 matches the received “drug type” among the multi-model numbers included in the main DB 14, and is permitted to be released according to the “publication level”. The one with “public level B” set is selected. At this time, as shown in FIG. 10, “major category”, “medium category”, and “small category” are recorded in the main DB 14 in association with a predetermined multi-model number address. In particular, among these, the middle class classifies drug types. For this reason, by searching for “medium classification” based on the received “drug type”, it is possible to select a multi-model number address that matches the received “drug type”. By the way, in the “drug type menu” in step II-5, for example, in addition to popular drugs, prescription drugs provided only to those who have received “publication level A” certification are also options. If a requester who is not certified for Level A requests for both a prescription drug and a prescription drug, the prescription drug request will be rejected based on the public level of the main DB 14, and in step II-11 Only the multi-model numbers related to are selected.

Next, in step II-12 (SII-12), the selected “multi-model number address”, “drug type”, and “Gno.” Are recorded in the memory unit B11. At this time, in this system, in step II-13 (SII-13), “anonymous multi-model number address” (position information) is recorded in accordance with a predetermined rule or the like for the “multi-model number address” (position information) recorded in the memory unit B11. Secondary position information) is set and linked to “multi-model number address” in the memory unit B11, and “anonymous multi-model number address” is recorded in the memory unit B11. This “anonymous multi-model area” is linked only to the “multi-model area” selected in step II-11, whereas “multi-model area” directly represents the position of the polymorphic pattern in the base sequence. It does not directly represent the position of the polymorphic pattern in the base sequence. In other words, the “anonymous multi-model number address” is set by assigning, for example, a serial number, an alphabetic symbol, a random number, or the like to the “multi-model number address” selected in step II-11.

  Next, in step II-14 (SII-14), according to the processing program 13, the requester is requested to confirm the consent regarding the submission of the polymorphic pattern (informed consent, hereinafter abbreviated as “IC”). To do. Specifically, in step II-14 (SII-14), the “individual IC confirmation input screen” is read from the screen memory 12 according to the processing program 13, and the received information on the “drug type” and the “multiple” selected in step II-11 are displayed. "Model number" is incorporated and displayed on the display means 22 of the personal computer 3. As the “individual IC confirmation input screen”, for example, a screen image as shown in FIG. 15 can be exemplified. That is, on the “individual IC confirmation input screen”, a multi-model number for requesting the requester is displayed. Note that the “multi-model address” selected in step II-11 does not have to be sent to the requester in the form of “individual IC confirmation input screen”, and to the requester before step II-14. You may send it.

  Next, in step II-15 (SII-15), the requester inputs consent regarding the submission of the polymorphic pattern according to the “individual IC confirmation input screen” displayed on the display means 22 of the personal computer 3. As a result, the requester agrees to submit the polymorphic pattern. In step II-15, the personal computer 3 records “multi-model number address” displayed on the “individual IC confirmation input screen” in the memory unit 26.

  Next, in step II-16 (SII-16), the data I of the genome related information recording medium 24 is accessed to read “Gno.”. In Step II-17 (SII-17), the read “Gno.” And “Individual IC confirmation” input in Step II-15 are transmitted to the shared computer 2.

  Next, in Step II-18 (SII-18), “Gno.” And “Individual IC confirmation” transmitted from the personal computer 3 are received by the shared computer 2, and the received “Individual IC confirmation” is stored in the memory. Save in part A10. When the “individual IC confirmation” is stored, the “individual IC confirmation” is associated with “Gno.” That matches the received “Gno.” In the data stored in the memory unit A10.

  Next, in step II-19 (SII-19), the “multi-model address” and “anonymous multi-model address” stored in steps II-12 and II-13 are read from the memory unit B11. In Step II-20 (SII-20), the read “multi-model number address” and “anonymous multi-model number address” are transmitted to the personal computer 3 in association with each other, and the “multi-model number address” is supported. Command information for instructing the submission of the “anonymous polymorphism address” associated with the polymorphic pattern and the polymorphic pattern to be output to the personal computer 3.

  Next, in Step II-21 (SII-21), the “multi-model number address” and “anonymous multi-model number address” and command information transmitted from the shared computer 2 are received. Next, in step II-22 (SII-22), it is determined whether the “multi-model number address” recorded in the memory unit 26 in step II-15 and the “multi-model number address” received in step II-21 match. To do. Here, the judgment of coincidence is a case where the multi-model number recorded in the memory unit 26 and the multi-model number received in step II-21 match in terms of notation, and a case where they substantially match. Including meaning. The notation coincidence means that the notation regarding a predetermined position on the base sequence is the same. Moreover, the substantial match means, for example, the case where the same position in the base sequence is indicated directly or indirectly even though it does not match on the notation.

  If it is determined in step II-22 that the “multi-model number address” recorded in the memory unit 26 and the “multi-model number address” received in step II-21 match, the polymorphism by the shared computer 2 is used. It means that there was no intention of illegal use / collection of patterns. Therefore, in this case, the process proceeds from Step II-22 to “Yes”, and Step II-23 is executed.

  If it is determined in step II-22 that the “multi-model number address” recorded in the memory unit 26 and the “multi-model number address” received in step II-21 do not match, the polymorphism by the shared computer 2 is used. This means that there is a possibility of intention of illegal use / collection of the pattern. Therefore, in this case, the process proceeds from Step II-22 to “No”, and the process of Step II-24 is executed. In addition, when there is no coincidence between the “multi-model number address” recorded in the memory unit 26 and the “multi-model number address” received in step II-21, for example, “multi-model number address” recorded in the memory unit 26 When there is a plurality, there is a meaning including a case where at least one or more multi-model numbers do not match.

  When proceeding to Step II-24, the shared computer 2 is notified of the refusal to submit the polymorphic pattern because the shared computer 2 has found the intention of unauthorized use / collection of the polymorphic pattern in Step II-22. To do. Note that the third party organization, which is a public or private organization, may be notified of the intention of unauthorized use / collection of the polymorphic pattern by the shared computer 2.

  On the other hand, in Step II-22, it is determined that there is a match between the “multi-model number address” recorded in the memory unit 26 and the “multi-model number address” received in Step II-21, and the process proceeds to Step II-23. In this case, the genome related information recording medium 24 is accessed according to the processing program 27. Then, in step II-25 (SII-25), the polymorphism pattern corresponding to the polymorphism pattern requested by the command information and the polymorphism pattern corresponding to the polymorphism area is selected from the data II of the genome related information 28 by the processing program 27. While extracting and reading, “Gno.” Is read from data I.

  Next, in Step II-26 (SII-26), the read polymorphic pattern is associated with the anonymous polymorphism address set for the polymorphism address of the polymorphism pattern, and is used together with "Gno." The data is transmitted from the computer 3 to the shared computer 2. That is, in Step II-26, the personal computer 3 transmits the anonymous polymorphism address, polymorphism pattern, and Gno. To the shared computer 2 via the communication network 1. At this time, the personal computer 3 does not transmit the multi-model address and the polymorph pattern in association with each other. Further, the anonymous polymorphism number does not directly represent the position in the base sequence of the polymorphism pattern. Therefore, even if the content transmitted in Step II-26 is leaked outside due to an unexpected situation, the position of the polymorphic pattern in the base sequence cannot be determined.

  Next, in Step II-27 (SII-27), the anonymous polymorphism address transmitted from the personal computer 3, the polymorphism pattern associated with the anonymous polymorphism area, and “Gno.” Are received and received. The polymorphic pattern is stored in the memory unit B11. When the “polymorphic pattern” is stored, “Gno.” And “anonymous multi-model number” that match the received “Gno.” And “anonymous multi-model number” in the data stored in the memory B11. ”Is associated with“ polymorphic pattern ”. In step II-27, “Gno.”, “Multi-model address”, “anonymous multi-model address” and “polymorph pattern” set for each multi-model address are recorded in the memory unit B11 in association with each other. Will be.

  Next, in step II-28 (SII-28), the main DB 14 is accessed according to the processing program 13. Then, in Step II-29 (SII-29), the main DB 14 is searched based on the “medium classification (drug type)”, “multi-model number area”, and “polymorphic pattern” stored in the memory unit B11. The “medicine type” (see FIG. 10) associated with the polymorphic pattern is read out. Here, the “drug type” is semantic information that means information such as components and doses suitable for an individual having a predetermined polymorphism pattern in the drug type classified as “medium category” as shown in FIG. is there. When a plurality of semantic information is associated with one polymorphic pattern, each semantic information is read out.

  Next, in Step II-30 (SII-30), the obtained “medicine type” is stored in the memory unit B11 in accordance with the processing program 13. Next, in step II-31 (SII-31), “medicine type” and “drug type” are read from the memory unit B11 according to the processing program 13. In step II-32 (SII-32), the “confirmation screen” corresponding to the read “drug type” and “drug type” is read from the screen memory 12 according to the processing program 13, and the display means 22 of the personal computer 3 is read. To display. As the “confirmation screen”, for example, a screen image as shown in FIG. 16 can be exemplified.

  Next, in Step II-33 (SII-33), the requester confirms the “medicine name” and “medicine type” in the “confirmation screen” and then the “order screen” in the “confirmation screen” of the personal computer 3. By clicking the “” button, the “order screen” (not shown) is read from the screen memory 12 and the order information is input. Here, the order information includes information for identifying the individual requester, the quantity for the medicine name of the medicine type displayed on the order screen, the receiving method and the payment method.

  Next, in step II-34 (SII-34), the genome-related information recording medium 24 is accessed according to the processing program 27, and "Gno." Is read from the data I of the genome-related information 28. In step II-35 (SII-35), according to the processing program 27, the read “Gno.” And the order information input in step II-33 are transmitted to the shared computer 2.

  Next, in step II-36 (SII-36), “Gno.” And “order information” transmitted from the personal computer 3 are received by the shared computer 2, and the order information is stored in the memory unit A10. When order information is stored, “order information” is associated with “Gno.” That matches the received “Gno.” In the data stored in the memory unit A10.

  Next, in step II-37 (SII-37), according to the processing program 13, an “order confirmation confirmation screen” (not shown) is read from the screen memory 12, and the “order confirmation confirmation screen” is displayed on the personal computer 3. Display on means 22. Thereafter, in step II-38 (SII-38), the requester confirms the order contents in accordance with the instructions on the “order confirmation screen”. Through the above steps, the requester completes an order for a medicine suitable for the individual who holds the genome-related information recording medium 24.

  On the other hand, in step II-39 (SII-39), “medicine name (information related to semantic information)”, “medicine type (semantic information)”, “quantity” and the like are obtained from the order information stored in the memory unit A10. Essential information is extracted and transmitted to the side providing the medicine (the side using the semantic information and information related to the semantic information) such as a pharmaceutical plant or a distribution center.

  The essential information is information necessary for manufacturing or delivering the medicine requested by the requester. Also, the side providing the drug refers to the one that manufactures the drug suitable for the requester by adjusting the drug component and component ratio from the “drug name” and “drug type”, or various drug component and component ratios. It is meant to include those selected and provided based on “medicine name” and “medicine type” from a plurality of types of medicines manufactured in advance. Through the above steps, the drug provider side manufactures or delivers a drug suitable for an individual who holds the genome-related information recording medium 24.

  Note that the shared computer 2 finally proceeds to Step II-40 (SII-40). In Step II-40, the contents stored in the memory unit A10 and the memory unit B11 are stored in the storage DB-A15 and the storage DB-B16, respectively, and then the contents stored in the memory unit A10 and the memory unit B11 are stored. to erase. At this time, it is preferable to delete the “anonymous multi-model number address” from the contents stored in the memory unit B11.

  Further, Step II-37 and Step II-38 are processes that finally confirm the requester's order, and are not essential processes in the present system. That is, this system may be a flow that proceeds to step II-39 after step II-36.

  In this case, the requester completes the order of the medicine suitable for the individual who holds the genome-related information recording medium 24 in Step II-35.

  As described above, according to the flowcharts shown in FIGS. 11 and 12, the multi-model number requested to be submitted in Step II-21 is a multi-model address other than the multi-model number scheduled to be submitted on the “individual IC confirmation input screen”. If it is the model number, it is regarded as illegal in the shared computer 2, and the process of submitting the polymorphic pattern is stopped. Thus, according to the present system, unauthorized use / collection of polymorphic patterns by the shared computer 2 can be prevented in advance.

  In particular, the operator who has the shared computer 2 does not have informed consent in advance and obtains the consent of the requester for “multi-model number place” that requests the requester to submit “polymorphic pattern”. It is desirable that laws and regulations that the business operator should not obtain the polymorphic pattern corresponding to the polymorphic area from the requester are required. According to such a statutory obligation, the “multi-model number” selected in step II-11 is surely sent from the shared computer 2 to the personal computer 3 in step II-14.

<Third Embodiment>
Next, as a third embodiment to which the present invention is applied, an information processing system for providing compatibility determination information with another person (other individual) to a user (user side individual) will be described. To do. That is, a case where the user requests compatibility determination information with a specific other person as “a request for goods and / or services” will be described as an example. In particular, in the present embodiment, an information providing system that provides compatibility determination information between a set of users to each user will be described. However, for convenience of explanation, the information providing system will be described as a simplified model. The information processing system described as the present embodiment uses the same names, symbols, and definitions for the same configurations and terms as those of the information processing system in the first embodiment and the second embodiment described above. The description of the configuration, operation, and terminology will be omitted.

  In the present embodiment, as shown in FIG. 17, in the main DB 14, “multi-model area” and “polymorph pattern” in the multi-model area are associated with “classification” for classifying a predetermined property. In addition to recording, “semantic information” meaning a predetermined “polymorphic pattern” is recorded. Furthermore, in the main DB 14, a “publication level” indicating whether or not the semantic information about a predetermined multi-model number address can be disclosed may be associated and recorded. Furthermore, in the present embodiment, the shared computer 2 includes a suitability determination database 31 (a suitability determination storage device) as shown in FIG. The suitability determination database 31 records a predetermined category and suitability determination information for each combination of semantic information in association with the predetermined category. That is, the combination of semantic information and the suitability determination information are associated with each other.

  Specifically, the main DB 14 is associated with multi-model numbers “1000” and “2000” with respect to “a certain property”, and semantic information indicating the combinations that can be taken by the polymorphic patterns in these multi-model numbers is “ It is recorded as “a” or “b”.

  Further, in the suitability determination database 31, when the combinations of the semantic information “a” and “b”, that is, the individual having the semantic information “a” and the individual having the semantic information “b” are appropriately combined, Suitability determination information indicating suitability in combination is recorded.

  In FIG. 17, for example, when the polymorphism patterns in the multi-model numbers “1000” and “2000” are “A” and “C”, or “G” and “T”, respectively, the semantic information regarding “a certain property” is obtained. When “a” is “G” and “C”, or “A” and “T” respectively, the semantic information regarding “a certain property” is “b”. In FIG. 18, the individual whose semantic information is “a” and the individual whose semantic information is “a” have the suitability determination information “xxx” for the “certain property”, and the semantic information is The individual with “a” and the individual with semantic information “b” are the individual with the judgment information “ΔΔΔΔ” and the semantic information “b” with respect to “certain property” and the semantic information. An individual whose “b” is “b” indicates that the suitability determination information is “xxxx” regarding “a certain property”.

  Further, in this example, a genome-related information recording medium 24 in which a multi-model area and a polymorphic pattern as shown in FIG. 19 are recorded will be described as an example. 19 exemplifies a genome related information recording medium 24 including a multi-model number address corresponding to the multi-model number addresses (“1000” and “2000”) illustrated in the main DB 14 of FIG. 17 and a polymorphic pattern thereof. is doing.

  For example, an information processing system for providing compatibility with another person to a user can provide compatibility determination information with another person to the user according to flowcharts as shown in FIGS. it can. In the flowcharts shown in FIG. 20 and FIG. 21, a step described as “(co-)” means a process in the shared computer 2, and a step described as “(piece)” means a process in the personal computer 3. ing.

  In this system, first, in step R-1 (SR-1), the user starts the processing program 27 recorded in the memory 23 of the personal computer 3 for the purpose of obtaining compatibility determination information with another person. . In step R-1, the processing program 27 drives the reading device 25 of the personal computer 3 to access the genome related information recording medium 24, and “Gno. "Is read out. In the following description, “Gno.” Recorded as data I in the genome-related information recording medium 24 is referred to as “self Gno.” And recorded as data I in the genome-related information recording medium 24 belonging to another individual. "Gno." Is called "other Gno." (Information on other individuals). The read “self Gno.” Is stored in the memory unit 26.

  Next, in step R-2 (SR-2), the read "self Gno." And the request information "a certain property" are sent to the shared computer 2 via the communication network 1 together with the "other party Gno." Send. This makes it possible to use the present system to display an intention to request provision of compatibility determination information with other individuals in “a certain property”. At this time, it is desirable to strictly carry out IC regarding the polymorphism pattern and compatibility determination information with other people. Also, a plurality of “partner Gno.” May be transmitted to request compatibility determination information with a plurality of other individuals.

  Next, in step R-3 (SR-3), the shared computer 2 receives “self Gno.”, “Certain property”, and “partner Gno.” Transmitted from the personal computer 3. The shared computer 2 activates the processing program 13 by receiving “self Gno.”, “Certain property”, and “partner Gno.”.

  Next, in step R-4 (SR-4), according to the processing program 13, "self Gno.", "Certain property" and "partner Gno." Received in step R-3 are stored in the memory unit A10. Access the main DB 14. In step R-5 (SR-5), the main DB 14 is searched based on “a certain property” according to the processing program 13, and a classification that matches the “a certain property” is extracted.

  Next, in step R-6 (SR-6), according to the processing program 13, the “multi-model number address” associated with the extracted classification “certain property” is read from the main DB. Further, the read “multi-model number address” is stored in the memory unit A10. Specifically, in the case of the main DB 14 shown in FIG. 17, “1000” and “2000” are extracted and stored as the multi-model numbers associated with “a certain property”.

  Next, in step R-7 (SR-7), “self Gno.” And “multiple model number” stored in the memory unit A10 according to the processing program 13 are read out, and “self Gno.” Is read out from the personal computer 3. And “multi-model address” and command information for instructing the submission of the “polymorph pattern” corresponding to the “multi-model address” to be transmitted are transmitted to the personal computer 3. Also, at this time, it may be ordered to submit additional information such as past illness and characteristics within the range defined by the IC as necessary.

  Next, in step R-8 (SR-8), the personal computer 3 receives “self Gno.” And “multi-model number address” transmitted from the shared computer 2. The received “self Gno.” And “multi-model number address” are recorded in the memory unit 26. In step R-9 (SR-9), the data II recorded in the genome-related information recording medium 24 is accessed according to the received command information (“self Gno.” And “multiple model number address”).

  In Step R-10 (SR-10), the data II of the genome related information recording medium 24 is searched to extract the commanded multi-model number address. In step R-11 (SR-11), the data II of the genome-related information recording medium 24 is searched based on the extracted polymorphism address, and the corresponding polymorphism pattern is read out. The read polymorphism pattern is recorded in the memory unit 26 in association with the polymorphism address. At this time, it is preferable to access the data I and confirm whether or not “self Gno.” Included in the instruction information is correct. In step R-10, in addition to the polymorphic pattern, additional information recorded in the data III, data IV, and data V may be simultaneously read and recorded in the memory unit 26 as necessary. Specifically, in the case of the genome-related information recording medium 24 shown in FIG. 19, the polymorphism patterns “A (multiple model number 1000)” and “C (multiple model number 2000)” correspond to the commanded multi-model number. Is read.

  Next, in step R-12 (SR-12), the polymorphism pattern associated with the polymorphism number temporarily recorded in the memory unit 26 and additional information recorded as necessary are displayed as “self Gno”. . ”Is output to the shared computer 2 via the communication network 1. In Step R-13 (SR-13), the polymorphic pattern associated with the polymorphism area, the self Gno. And additional information recorded as necessary are received by the shared computer 2, and the polymorphic pattern received is received. Is associated with the multi-model number and recorded in the memory unit A10. Specifically, the polymorphism pattern “A” is recorded in the memory part A10 for the multi-model address “1000”, and the polymorphism pattern “C” is recorded for the multi-model address “2000”.

  Next, in step R-14 (SR-14), the main DB 14 is accessed according to the processing program 13. In step R-15 (SR-15), the main DB 14 is searched based on the received polymorphism address and the polymorphism pattern, and “semantic information” associated with the matched polymorphism pattern is extracted. The extracted “semantic information” is stored in association with “self Gno.”, “Certain property”, and “partner Gno.” Stored in step R-4. Specifically, in the case of FIG. 17, semantic information “a” is extracted and stored for combinations in which the polymorphism patterns of the multi-model numbers “1000” and “2000” are “A” and “C”, respectively.

By this step R-15, as shown in FIG. 22, a table in which “self Gno.”, “Partner Gno.”, “Classification (a certain property)” and semantic information are associated can be created in the memory unit A10. it can. Here, steps R-1 to R-15 can be processed sequentially or simultaneously by a plurality of users. For example, to create the table shown in FIG. 22, steps R-1 to R for five individuals whose self Gno. Is “0001”, “0002”, “1234”, “5678”, and “3333”. Can be created by running -15.
In order for the user who is self Gno. “0001” to obtain the compatibility determination information with the individual who is Gno. “0002”, the user who is self Gno. “0002” is set to “0001”. After executing steps R-1 to R-15, the following steps are executed.

  Next, in step R-16 (SR-16), the table shown in FIG. 22 is searched, and the combination of “self Gno.” And “partner Gno.” On one side is changed to “partner Gno.” And A combination with “self Gno.” Is extracted, and “semantic information” associated with each combination is read out. Specifically, the semantic information “a” is extracted for the user of the self Gno. “0001” designating the partner Gno. As “0002”, and the self Gno. Semantic information “b” is extracted for the user. That is, in step R-16, the combination of the semantic information “a” and “b” is read.

  Next, in step R-17 (SR-17), the conformity determination database 31 is accessed, and a combination of semantic information that matches the combination of the “semantic information” read out in step R-16 with respect to “a certain property”. The associated “compatibility determination information” is read out. Specifically, when the combination of semantic information “a” and “b” is read in step R-16, “ΔΔΔΔ” can be read from the suitability determination database 31 as suitability determination information.

  Next, in step R-18 (SR-18), the “compatibility determination information” read in step R-17 is transmitted to the personal computer 3 together with “self Gno.”. In step R-18, suitability determination information with a user regarding a certain property may be transmitted to another individual.

  Next, in step R-19 (SR-19), the personal computer 3 receives “self Gno.” And “compatibility determination information”. The received “compatibility determination information” is recorded in the memory unit 26 in association with “a certain property”. In the memory unit 26, a table as shown in FIG. 23 can be created. Next, in step R-20 (SR-20), “compatibility determination information” and “partner Gno.” Recorded in the memory unit 26 are displayed on the display device 22 in accordance with the processing program 27. As a result, the user can use the genome-related information 28 recorded in the genome-related information recording medium 24 to obtain compatibility determination information with a specific individual regarding a certain property.

  As described above, according to the flowcharts shown in FIGS. 20 and 21, it is possible to provide the user with compatibility determination information with a specific other individual. This system can be used when, for example, persons who first meet each other judge the compatibility between themselves and the other party. In this case, first meeting people exchange first “Gno.” With each other, and each becomes a user and executes the flowcharts shown in FIGS. 20 and 21. In this case, as the personal computer 3, for example, a mobile phone to which a semiconductor memory can be attached and detached can be used. This makes it possible for the first meeting people to judge each other's compatibility at an early stage, which is helpful in determining how to contact the other party.

  In addition, this system can be used for ordinary people. In human society, you need to moderately interact with others, whether you like it or not. In such a case, using this system to know in advance the compatibility with others that need to be associated is helpful in building appropriate human relationships.

  Furthermore, this system is used not only to know the compatibility between a user and a specific other person, that is, the compatibility in a one-to-one relationship, but also to check the compatibility between a user and a specific group. be able to. In this case, the user can know the compatibility with each member included in the group. Thus, the user can maximize the ability of each member included in the group or activate the group. On the other hand, it is also possible to find a way for users to make maximum contributions to the group.

1 ... Communication network 2 ... Shared computer 3 ... Personal computer

Claims (4)

It has transmission / reception means and control means, and is stored in the storage area where the position information indicating the position in the base sequence and the classification information of the goods and / or services are stored in association with each other, and the position information and the position indicated by the position information. A compatibility determination in which a plurality of base sequence related information and semantic information meaning each of the plurality of base sequence related information are stored in association with each other and a combination of the semantic information and the compatibility determination information are stored in association with each other. Information processing means that can access the storage area
A step a in which the transmission / reception means receives request information of goods and / or services via a network ;
A step b in which the transmission / reception means receives information on another individual from the side that sends the request information in the step a via a network ;
Step c for reading position information corresponding to the request information from the storage area in which the control means stores the position information and the classification information in association with each other ;
Transmitting and receiving the position information read out in step c by the transmission / reception means to an information processing means capable of accessing a storage area in which position information relating to the individual and base sequence related information are stored in association with each other;
And step e of the transmitting and receiving means receives via the network the nucleotide sequence-related information corresponding to the positional information transmitted in step d,
The storage area in which the control means stores a plurality of base sequence related information that can be taken at the position that the position information means, and semantic information that respectively signifies the plurality of base sequence related information in association with each other. A step f of searching and reading out semantic information meaning the base sequence related information received in step e ;
The control means is based on the information related to the other individual received in step b, the semantic information read in step f , and the other individual in step b becomes the side that sends the request information in step a. the suitability for determining based on the semantic information of the other individuals obtained by implementing the steps a~f become other individuals side individuals in step b for transmitting the request information in step a An information processing method related to a base sequence that searches a storage area and executes step g of reading compatibility determination information between an individual belonging to the side that has transmitted request information in step a and another individual in step b . It has transmission / reception means and control means, and is stored in the storage area where the position information indicating the position in the base sequence and the classification information of the goods and / or services are stored in association with each other, and the position information and the position indicated by the position information. A compatibility determination in which a plurality of base sequence related information and semantic information meaning each of the plurality of base sequence related information are stored in association with each other and a combination of the semantic information and the compatibility determination information are stored in association with each other. Access to the storage area for
Request information receiving means for causing the transmitting / receiving means to function to receive request information of goods and / or services via a network; and
Other individual information receiving means for causing the transmitting / receiving means to function to receive information about other individuals from the side that sends the request information by the request information receiving means, via a network;
Position information reading means for causing the control means to function to read position information corresponding to the request information from the storage area in which the position information and the classification information are stored in association with each other;
A function of transmitting the position information read by the transmission / reception means by the position information reading means to an information processing means that can access a storage area in which position information related to an individual and base sequence related information are stored in association with each other. Position information transmitting means for causing
Base sequence related information receiving means for causing the transceiver means to receive base sequence related information corresponding to the positional information transmitted by the positional information transmitting means via a network;
The storage area in which the control means stores a plurality of base sequence related information that can be taken at the position that the position information means, and semantic information that respectively signifies the plurality of base sequence related information in association with each other. Semantic information reading means for searching and functioning to read out semantic information meaning the base sequence related information received by the base sequence related information receiving means;
Based on the information about the other individual received by the other individual information receiving unit, the control unit reads the semantic information read by the semantic information reading unit, and the other individual in the other individual information receiving unit receives the request information. The request information sending means in the receiving means and the individual sending the request information in the request information receiving means become another individual in the other individual information receiving means and the request information receiving means to read the semantic information Based on the semantic information of the other individual obtained by performing the processing by the means, search the storage area for suitability determination, the individual belonging to the side that sent the request information in the request information receiving means and the Information relating to a base sequence comprising: compatibility determination information reading means that functions to read compatibility determination information with other individuals in other individual information receiving means Processing equipment. It has transmission / reception means and control means, and is stored in the storage area where the position information indicating the position in the base sequence and the classification information of the goods and / or services are stored in association with each other, and the position information and the position indicated by the position information. A compatibility determination in which a plurality of base sequence related information and semantic information meaning each of the plurality of base sequence related information are stored in association with each other and a combination of the semantic information and the compatibility determination information are stored in association with each other. Information processing means that can access the storage area
A step a in which the transmission / reception means receives request information of goods and / or services via a network;
A step b in which the transmission / reception means receives information on another individual from the side that sends the request information in the step a via a network;
Step c for reading position information corresponding to the request information from the storage area in which the control means stores the position information and the classification information in association with each other;
Transmitting and receiving the position information read out in step c by the transmission / reception means to an information processing means capable of accessing a storage area in which position information relating to the individual and base sequence related information are stored in association with each other;
Receiving the base sequence related information corresponding to the position information transmitted by the transmitting / receiving means in the step d via a network;
The storage area in which the control means stores a plurality of base sequence related information that can be taken at the position that the position information means, and semantic information that respectively signifies the plurality of base sequence related information in association with each other. A step f of searching and reading out semantic information meaning the base sequence related information received in step e;
The control means is based on the information related to the other individual received in step b, the semantic information read in step f, and the other individual in step b becomes the side that sends the request information in step a. Based on the meaning information of the other individual obtained by performing steps a to f, the individual sending the request information in step a becomes another individual in step b. An information processing program relating to a base sequence that searches a storage area and executes step g of reading compatibility determination information between an individual belonging to the side that has transmitted request information in step a and another individual in step b. It has transmission / reception means and control means, and is stored in the storage area where the position information indicating the position in the base sequence and the classification information of the goods and / or services are stored in association with each other, and the position information and the position indicated by the position information. A compatibility determination in which a plurality of base sequence related information and semantic information meaning each of the plurality of base sequence related information are stored in association with each other and a combination of the semantic information and the compatibility determination information are stored in association with each other. Information processing means that can access the storage area
A step a in which the transmission / reception means receives request information of goods and / or services via a network;
A step b in which the transmission / reception means receives information on another individual from the side that sends the request information in the step a via a network;
Step c for reading position information corresponding to the request information from the storage area in which the control means stores the position information and the classification information in association with each other;
Transmitting and receiving the position information read out in step c by the transmission / reception means to an information processing means capable of accessing a storage area in which position information relating to the individual and base sequence related information are stored in association with each other;
Receiving the base sequence related information corresponding to the position information transmitted by the transmitting / receiving means in the step d via a network;
The storage area in which the control means stores a plurality of base sequence related information that can be taken at the position that the position information means, and semantic information that respectively signifies the plurality of base sequence related information in association with each other. A step f of searching and reading out semantic information meaning the base sequence related information received in step e;
The control means is based on the information related to the other individual received in step b, the semantic information read in step f, and the other individual in step b becomes the side that sends the request information in step a. Based on the meaning information of the other individual obtained by performing steps a to f, the individual sending the request information in step a becomes another individual in step b. An information processing program related to a base sequence that searches a storage area and executes step g of reading compatibility determination information between an individual belonging to the side that has transmitted the request information in step a and another individual in step b is recorded. Computer-readable recording medium.

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