JP5111578B2 - Blood analyzer - Google Patents

Description

The present invention relates to an analysis apparatus used for various tests such as clinical tests such as blood tests and urine tests, and tests in the industrial field such as quality tests of toners and pigments. The present invention relates to an analyzer provided with a display device.

Among the various analyzers as described above, for example, in blood analyzers, basic measurement items include white blood cell count (WBC), red blood cell count (RBC), platelet count (PLT), hemoglobin amount (HGB), and hematocrit. Five items of value (HCT) are known. In addition, the average red blood cell volume (MCV), the average red blood cell blood pigment amount (MCH), and the average red blood cell blood pigment concentration (MCHC) calculated from these data may be added to the measurement items to measure a total of eight items. As a method for measuring blood cells of WBC, RBC, and PLT, an electrical resistance method and a light scattering method are well known. For example, in the electrical resistance method, a small amount of blood sample is supplied to a detector, that is, a micropore (a rectifying element having a function as an orifice) through which an electric current is passed, and an impedance change generated when passing through the micropore. To obtain the number and particle size distribution of blood cells. As a method for measuring HGB, a method for measuring the absorbance of a hemolyzed blood sample is used. It is well known that a method for measuring HCT is obtained by processing an RBC measurement signal.

Among WBC, RBC, and PLT blood cell measurements, RBC is about 4 million cells / μl for normal specimens, PLT is about 200,000 cells / μl, and the number of blood cells is different by one digit. Measurements can be made simultaneously on the same sample. However, WBC is a normal sample of about 5000 / μl, which is about three orders of magnitude less than RBC, and the size of blood cells is almost the same as that of red blood cells, making it difficult to measure simultaneously on the same sample. It is. Therefore, a sample obtained by hemolyzing red blood cells is used for WBC measurement.

In addition, considering the case where children cannot obtain a sufficient amount of blood and cannot secure a sufficient amount of blood, or when measuring a sample with an abnormally high blood cell count, the normal measurement mode (the measurement in this mode is the whole blood mode) In addition to the measurement), a dilution measurement mode (measurement in this mode is called dilution mode measurement) is performed in which the blood is diluted to increase the sample volume, and then the measurement is performed. An enabled blood analyzer is used. As described above, as a blood analyzer capable of performing measurement in a plurality of measurement modes, XE-2100 manufactured by Sysmex Corporation can be exemplified.

In addition, when preparing, a constant volume flow path, a pipette, A sampling valve composed of an electromagnetic valve or the like, a mix chamber for preparing a blood sample, etc. are used, and a monitor sensor or the like is attached to these as necessary, or the operation time is measured by a timer. Yes. When the sensor or the like detects an abnormality or the operation is not completed within a certain time, an alarm is issued to inform the measurer that a trouble has occurred.

Further, some blood analyzers and other various analyzers use a touch panel type input / display device capable of input operation and output display from the viewpoint of miniaturization of the device and improvement of operability. The touch panel has a pressure sensor attached to a screen composed of liquid crystal or the like. Then, an icon such as a button is displayed in a specific area on the screen, and when the measurer touches the area where the icon is displayed, a pressure sensor corresponding to the specific area detects it and generates a signal It has become. Some analyzers equipped with such a touch panel type input / display device display a start button on the screen for starting an operation for measuring a sample. In such an analyzer, trouble occurs in any part of the analyzer, and the measurement operation for the next sample cannot be started as it is or the state where it is not preferable to start (these are referred to as “measurement impossible” states). ), There is also a control that invalidates the input even if the start button is touched.

When performing measurement using an analyzer that uses a display device, the measurement result display screen is displayed again after the measurement results for each blood measurement item are displayed and after the next measurement preparation process (such as a cleaning process) is completed. Is returned to the main screen, that is, the screen where the start button is displayed, and the next analysis is started by performing an input operation to start the measurement. You must switch to.

In addition, as described above, when control is performed to invalidate the input by the start button as a result of trouble occurring in any part of the analyzer, the measurer who does not notice that the measurement is impossible is performed. Even though the input becomes invalid, the start button displayed on the screen is repeatedly pressed many times (so-called “empty press”). When the number of times of idling is excessive, a load is applied to the touch panel, causing a failure.

The present invention, when measuring affecting trouble constant result occurs, thereby preventing the measurement from being started, and to provide an analysis apparatus as much as possible reduce the burden on the touch panel.

Further, measuring person, and an object thereof is to provide a blood analyzer which aimed to simplify the screen display operation when continuously measuring a plurality of blood.

The blood analyzer of the present invention made to solve the above problems is a measurement that performs an input means, a measurement operation for preparing a measurement sample from blood, and acquiring a signal from blood cells in the measurement sample, and a washing operation. Means for starting measurement operation by means of measurement, means for starting measurement, display means for displaying screen, and means for displaying main screen including measurement mode selection means capable of selecting measurement mode when power is turned on In the measurement mode selected by the operation of the measurement mode selection unit, the measurement result is calculated from the signal acquired by the measurement unit and the measurement result is started. Display the measurement screen for displaying on the display means, the state where the predetermined input by the input means is not input continues for a predetermined period after the measurement result is displayed That when displayed on the display unit main window, when a predetermined input is made by the input means before the measurement result has passed a predetermined time period from the display of the control unit Ru is displayed on the display means a predetermined screen And.

According to the invention, the measuring person and to automatically switch to the main screen when the input operation is not made to simplify the effort of each time switching the screen.

Further, the analyzer of the present invention made to solve the above problems is a touch panel type in which output information is displayed on the screen and input associated with the specific position is performed by touching the specific position on the screen. An analyzer using the input / display device of the present invention, the analyzer having a monitoring means for monitoring equipment driven in the analyzer, and a start button for starting the measurement displayed on the input / display device When the main screen is displayed, when the abnormality is detected by the monitoring unit, the control unit performs control to delete the display of the start button from the screen.

According to the present invention, the analyzer is configured to monitor the operation of the device driven in the apparatus by the monitoring means. As this monitoring means, various sensors (panel open / close sensor, pipette position sensor, sample detection sensor, sample adapter detection sensor, float switch, pressure sensor, etc.) and program processing time which are installed in the apparatus are measured. A control unit built-in timer and the like are included. When the monitoring unit detects an abnormality that affects the measurement, the start button is not displayed on the main screen on which the start button is displayed. This prevents the measurer from starting the measurement accidentally because the start button is not displayed. In addition, since the start button is not displayed in the first place, there is no need to press the start button, and the burden on the touch panel is reduced.

According to the present invention, when the measurement results affecting trouble or the like occurs in the analyzer, since the start button is prevented from being displayed, it is possible to prevent the measurement from being started. Moreover, idling can be prevented and the burden on the touch panel can be reduced.

Further, since the screen is automatically returned to the main screen when the measurement screen is not operated for a predetermined time, the operation can be simplified.

The figure which shows the external appearance structure of the blood analyzer which is one Example of this invention. The figure which shows the block configuration of the blood analyzer which is one Example of this invention. The flowchart explaining operation | movement of the blood analyzer which is one Example of this invention. The figure which shows the transition of the screen displayed with the blood analyzer which is one Example of this invention. The figure which shows an example of a main screen (state which designated the whole blood mode). The figure which shows an example of a main screen (state which designated dilution mode). The figure which shows an example of a main screen (measurement impossible state). The figure which shows an example of a measurement screen (immediately after a measurement start). A figure showing an example of a measurement screen (at the end of WBC measurement). The figure which shows an example of a measurement screen (at the time of completion | finish of RBC measurement). The figure which shows an example of the measurement screen which displays all the measurement items (8 items). The figure which shows an example of a measurement screen (at the time of statistical data display of WBC measurement). The figure which shows an example of a measurement screen (at the time of the statistical data display of RBC and PLT measurement). The figure which shows an example of a measurement screen (when the display item is set arbitrarily).

Hereinafter, the analyzer of the present invention will be described with reference to examples. In the following embodiments, the analyzer is a blood analyzer. The analyzer uses a touch panel type input / display device for various input operations and output display.

FIG. 1 is a diagram showing an external configuration of a blood analyzer according to an embodiment of the present invention. As shown in the figure, the blood analyzer 1 is housed in one housing 2, and an input / display device 3 on which the measurer inputs and displays output information on the front surface of the housing 2, and the measurer sets the sample. A specimen setting panel 4 that is opened when a sample is set in the apparatus is provided. A push button 5 for opening and closing the sample set panel 4 is provided above the sample set panel 4.

Further, inside the housing 2, a sample setting unit 6 in which a sample is set when the push button 5 is pressed, a detection unit 7 for detecting the sample set in the sample setting unit 6, and a sample using a reagent Necessary for the operation of the fluid control unit 8 for preparing the sample and moving the specimen sample, the control substrate unit 9 for mounting the substrate on which the control circuit necessary for controlling and driving the device is mounted, and various devices used in the device A power supply unit 10 for supplying direct current power (+12 V) and a printer unit 11 for printing the detection result are housed.

FIG. 2 is a block configuration diagram of the blood analyzer of FIG. In the figure, a power supply unit 10 converts a voltage received from a commercial AC power source into a DC voltage and supplies it to a control unit 500 and a drive circuit unit 501.

The control unit 500 includes a microcomputer including a CPU, a ROM, and a RAM, and the drive circuit unit 501 includes a driver circuit, an I / O port, and the like. The input / display device 3 includes a liquid crystal display 3 a and a touch panel 3 b and is connected to the control unit 500. The drive circuit unit 501 includes a panel open / close sensor J1, a specimen detection sensor J2, a specimen adapter detection sensor J3, a pipette upper position sensor J4, a pipette front position sensor J5, and a pressure for detecting a negative pressure in a drain chamber (not shown). Sensor J6, float switch J7 that detects the amount of liquid stored in drain chamber WC, light-emitting diode 59 is turned on, hemoglobin detector 502 that receives the output of photodiode 68, and a constant DC current is passed between electrodes 58 and 67. The output signal from the resistance detection unit 503 that detects a change in impedance between the electrodes 58 and 67 is A / D converted and output to the control unit 500.

The control unit 500 receives the output signal from the drive circuit unit 501 and the output signal from the touch panel 3b, and processes these signals by a predetermined processing program. Based on the processing result, the control unit 500 causes the drive circuit unit 501 to add a pipette up / down motor 405, a pipette front / rear motor 205, a syringe pump motor STM4, a syringe pump motor STM5, a negative pressure pump P1, a drainage pump P2, and so on. The air pump P3 and the electromagnetic valves SV1 to SVn are driven, the liquid crystal display 3a is displayed, and the printer unit 11 is caused to output a print.

And the control part 500 displays various display screens on the liquid crystal display 3a based on the information memorize | stored in ROM using the predetermined program memorize | stored in ROM. These various display screens include a main screen on which a start button for starting measurement is displayed, a mode selection screen on which mode selection buttons are displayed, and a setting screen for setting measurement items. In the main screen (FIGS. 4A, 5, and 6) of this embodiment, a start button and a mode selection button are displayed at the same time.

Hereinafter, the analysis operation of the blood analyzer will be described with reference to the flowchart of FIG. 3, and the transition of the screen displayed on the input / display device 3 will also be described with reference to FIG. As shown in FIG. 3, first, when the blood analyzer is turned on (s1) and a predetermined preparation time elapses (s2), the liquid crystal display 3a of the input / display device 3 includes the characters “standby”. A screen (FIG. 4A) is displayed. This main screen includes a mode selection button and a start button.

Therefore, the measurer attaches the sample container containing the sample to the sample setting unit 6 (s4). Next, the measurer selects whether the measurement is performed in the whole blood mode or the dilution mode (s5). Selection is performed by touching one of the mode selection buttons in the main screen. When the sample in the attached specimen container is a whole blood sample (sample when performing normal measurement), the measurer is displayed in red on the main screen displayed on the input / display device 3. The “whole blood mode” button is touched, and if it is a diluted sample, the “dilution mode” button displayed in yellow is touched (s5).

At this time, when the “whole blood mode” button is touched, the start button in the main screen turns red, and when the “dilution mode” button is touched, the start button turns yellow. At this time, the control unit 500 functions as a color change unit 500a that changes the color of the button and a color change control unit 500b that controls the color change unit.

Subsequently, the user touches the start button while confirming the measurement mode from the color of the start button displayed on the main screen (s6). The control unit 500 determines which of the “whole blood mode” and the “dilution mode” is selected, and starts processing of a program corresponding to each (s7).

When the control unit 500 receives an abnormal signal from any of the devices in the apparatus and determines that the abnormality affects the measurement, the start button in the main screen is erased, and The start button is not touched.

Here, when the measurement operation is started based on the input by the start button, the screen displayed by the input / display device 3 is switched from the main screen (FIG. 4A) to the measurement screen (FIG. 4B). Although the measurement items are displayed on the measurement screen at this time, the measurement results of the respective items are not displayed because they have not been obtained yet. In addition, the measurement items displayed at this time are five items (WBC, RBC, HGB, HCT, PLT) which are generally said to be important by the initial setting.

When the “whole blood mode” is selected, an RBC measurement sample and a WBC measurement sample are prepared from whole blood (s8, s9). When the “dilution mode” is selected, an RBC measurement sample and a WBC measurement sample are prepared from diluted blood (s16, s17).

Subsequently, measurement of WBC and HGB (hemoglobin concentration) is performed using the WBC measurement sample prepared in step 9 (s9) (s10), and when the measurement result is obtained, first, data of the measurement results of these two items are obtained. It is displayed on the measurement screen being displayed (FIG. 4C) (s11).

Further, RBC measurement is performed using the RBC sample prepared in step 8 (s8) (s12), PLT (platelet count), HCT (hematocrit value) and other measurement items are calculated (s13). The measurement result and the calculation result are displayed on the measurement screen (s14). At this time, five measurement results are displayed on the measurement screen with a large character size (FIG. 4D).

Subsequently, cleaning is started in preparation for the next measurement (s15). It is monitored whether a touch panel operation for displaying 8 items is performed during cleaning (s18). When an input operation for displaying 8 items is performed, the screen shifts to an 8-item display screen (FIG. 4E) with a small character size (s19). . Once the screen is shifted to the 8-item display screen (FIG. 4E), the 8-item display is displayed until the “return” button displayed at the upper right of the screen is touched (s20). When the “return” button is touched, the screen is switched to the main screen (FIG. 4A) (s21). If no input operation is performed in step 18 (s18), the five-item display screen (FIG. 4D) is displayed as it is and the end of cleaning is waited (s22).

When the cleaning is completed, the screen is switched to the main screen (FIG. 4A) (s21), and the process returns to step 3 (s3) to prepare for the next sample measurement. That is, when the operation for displaying the eight items is not performed before the cleaning is completed, it is automatically switched to the main screen (FIG. 4A) assuming that the eight items are not displayed. In determining whether or not to automatically switch to the main screen (FIG. 4A), the control unit 500 needs to determine whether or not the cleaning has been completed. In this embodiment, the control unit 500 determines the end of cleaning based on signals from sensors and the like provided in each part of the analyzer. In addition, a separate timer is provided, and when a certain time has elapsed from the start of cleaning, it is considered that the cleaning has ended, and the five-item display screen (FIG. 4D) is automatically displayed as described above (FIG. 4A). It is also possible to configure the control unit 500 to switch to)). Further, when a predetermined time has elapsed since it was determined that the cleaning was finished, control is performed so that the five-item display screen (FIG. 4D) is automatically switched to the main screen (FIG. 4A) as described above. It is also possible to configure the unit 500 to control.

Next, display contents of the main screen and the measurement screen will be described.

Main screen FIGS. 5 and 6 are diagrams showing the display contents of the main screen. FIG. 5 shows the screen state when the whole blood mode is selected, and FIG. 6 shows the screen state when the dilution mode is selected. In the figure, 511 is a measurement mode area, 512 is a whole blood mode selection area where a push button is displayed, and 514 is a dilution mode selection area where a push button is displayed. 516 is a start button area where a start button is displayed, 518 is a P / F area for feeding the paper of the printer, 520 is a menu area for selecting various menus such as maintenance, setting, and calibration, and 522 is an apparatus QC area for performing accuracy control of 524, a measurement result area for calling a measurement result display screen for a sample that has already been measured, 526 is a shutdown area for starting a shutdown operation (stopping the apparatus after cleaning), 528 is a dispensing area of Me line song dispensing required by the dilution mode.

A touch panel is attached to the corresponding position in each of these areas, and each function is input by touching (pushing) with a finger or the like, and each function is executed by a program stored in the control unit 500 in advance. It is processed by. Reference numeral 510 denotes an area for inputting a sample number, and a numerical value or the like is input from a keyboard (not shown) (which may be displayed as a pop-up menu).

The measurement mode selection will be described. As shown in FIG. 5, a red “whole blood button” and a yellow “dilution button” are drawn in the whole blood mode area 512 and the dilution mode area 514, respectively. The “whole blood button” and the “dilution button” are made to have different button colors, and errors are reduced by using an identification action by color.
Then, for example, when the “whole blood button” is touched, it is displayed as if it was pushed in, and the “dilution button” is displayed as if it is not pushed and appears to pop out. On the contrary, when the “dilution button” is touched, it is pushed in and the “whole blood button” is displayed as popping out. As a result, even a button on the touch panel that is a two-dimensional plane is visually displayed in a three-dimensional manner, and it is clear which is selected, so that an error in the measurement mode is less likely to occur.

In addition, a display indicating the meaning of whole blood or dilution, such as “Whole Blood” and “Pre-Diluted”, is displayed at the bottom of the “whole blood button” and “dilution button” to prevent further mistakes. It is.

Furthermore, the color of the start button in the start area 516 is changed in conjunction with the color of the selected measurement mode button. For example, in this embodiment, the “whole blood button” is displayed in red and the “dilution button” is displayed in yellow. However, when the whole blood mode is selected by pressing the “whole blood button”, the start button is also red. When the “dilution button” is pressed and the dilution mode is selected, the start button also turns yellow. The “whole blood button” may be always displayed in red, or may be displayed in red only when the whole blood mode is selected. Similarly, the “dilution button” may be always displayed in yellow, or may be displayed in yellow only when the dilution mode is selected. In any case, the “whole blood button” and “dilution button” need not be displayed in the same color at the same time. In addition, it is preferable that the color of each button is selected as a color that is easily distinguishable in terms of color.

On the main screen, touch the start button to start the measurement. However, if the cleaning operation is not completed, the reagent is insufficient, or the apparatus is in a trouble state, if the measurement operation is started, it may cause further failure. Therefore, the control unit 500 monitors the signal from the drive circuit unit 501 and the like so as to grasp the reagent shortage and the apparatus state, and displays the “start button” in the start button area 516 when the measurement preparation is completed. When preparation is not completed and measurement is not possible or trouble occurs, the start button is not displayed in the start button area 516 as shown in FIG. It makes it clear that it is in a state where it is not possible to start as well as eliminating the button.

Targets monitored by the controller 500 include, for example, cleaning process end information and apparatus trouble information based on various sensor outputs such as the panel opening / closing sensor J1 and the specimen detection sensor J2 shown in FIG. If the start button is not displayed, a displayable space is created in the start button, so that a large character indicating that measurement is not possible may be performed.

Measurement screen Next, a screen displayed during measurement will be described. 8 shows the measurement screen immediately after the start of the measurement by pressing the start button, FIG. 9 shows the measurement screen after the measurement result by the WBC measurement sample is obtained, and FIG. 10 shows the measurement result by the RBC measurement sample. The measurement screen immediately after the measurement is completed is shown. In FIGS. 8 and 9, which are screens during measurement, a graphic display (triangular display) 530 indicating the progress of the measurement by color change is displayed in the lower stage.

On this measurement screen, five basic items (WBC, RBC, PLT, HGB, HCT) are displayed with the character size enlarged. Since the measurement result is not obtained immediately after the start of measurement, the measurement item (and its unit) is simply displayed. When about 20 seconds elapse after the measurement is started, the measurement using the WBC measurement sample is completed, and thus WBC and HGB data obtained by this measurement are immediately displayed as shown in FIG. After about 80 seconds, the measurement with the RBC measurement sample is completed, so that five items of results are displayed as shown in FIG.

Here, by touching a “→” button (referred to as “forward button”) 532 which is a touch button provided in the lower right of FIG. 10, MCV (average erythrocyte volume), MCH (average erythrocyte hemoglobin), MCHC An eight-item measurement result display screen as shown in FIG. 11 including each item of (average erythrocyte hemoglobin concentration) is displayed. This screen displays all items to be measured by this blood analyzer, but the character size is small because of the large number of items.

In addition, by touching the forward button 532 in FIG. 11, various statistical data screens related to the measurement results of the WBC measurement sample and the RBC measurement sample as shown in FIGS. 12 and 13 may be displayed. Moreover, it may be set so as to be able to return from the 8-item display state of FIG. 11 (or FIG. 4 (e)) to the 5-item display state of FIG. 10 (or FIG. 4 (d)).

Thereafter, the user touches the “return” button 534 displayed in the upper right of FIGS. 11, 12, and 13 to return to the main screen.

Depending on the measurer, there is a case where it is desired to move on to the next measurement without considering the display of eight items (or the statistical data screen). Therefore, when the operation state has not been operated for about 20 seconds from when the screen shown in FIG. 10 is reached until the cleaning process is completed, that is, when there is no operation of the “forward button” 532 for viewing the 8-item display. 11 automatically returns to the main screen as it is not necessary to view the data of FIG.

In the above embodiment, the basic 5 items are set to be displayed after the measurement is started. However, among the measurable items, only any desired items can be registered in advance, and the screen displaying 8 items is as follows. Another screen may be provided that displays only arbitrarily selected items.

FIG. 14 shows a screen when only WBC and RBC are registered as the first measurement screen. The operation of registering only an arbitrary item is performed by touching the menu area 520 in FIGS. 5 and 6 to call a “setting” screen and executing a program for specifying a measurement item from the “setting” screen. In this program, the character size is predetermined according to the number of display items (for example, 20 points for 2 items, 16 points for 5 items, etc.), and the character size is determined according to the number of items.

The above embodiment relates to a blood analyzer, but it can also be applied to analyzers for various clinical tests including urine analyzers, and analyzers in industrial fields such as quality inspection of toners and pigments.

500: Control unit 501: Drive circuit unit 511: Measurement mode area 512: Whole blood mode button area 514: Dilution mode button area 516: Start button area 520: Menu area

Claims (11)

Input means;
A measurement means for preparing a measurement sample from blood and obtaining a signal from blood cells in the measurement sample, and a cleaning operation;
A measurement start means for starting a measurement operation by the measurement means;
Display means for displaying a screen;
When the power is turned on, the main screen having the measurement mode selection means capable of selecting the measurement mode is displayed on the display means, the measurement operation by the measurement means is started by the operation of the measurement start means, and the measurement mode selection means is operated. In the measurement mode selected by the above, the measurement result is calculated from the signal acquired by the measurement means, and the measurement screen for displaying the measurement result is displayed on the display means, and the predetermined input by the input means is not input. When the state continues for a predetermined period after the measurement result is displayed, the main screen is displayed on the display means, and when the predetermined input is made by the input means before the predetermined period elapses after the measurement result is displayed, blood analyzer and a control unit which Ru is displayed on the display means a predetermined screen. The measurement screen includes a detailed display means for causing the display means to display a detailed result screen for displaying details of the measurement result as a predetermined screen ,
The blood analyzer according to claim 1, wherein the predetermined input is an operation of detail display means by an input means.   The blood analyzer according to claim 2, wherein the control unit continues displaying the detailed result screen even if a predetermined period elapses during display of the detailed result screen. The detailed result screen includes a main screen display means for displaying the main screen on the display means,
The blood analyzer according to claim 3, wherein the control unit causes the display unit to display the main screen when the main screen display unit is operated while the detailed result screen is displayed. The measurement screen includes a main screen display means for displaying the main screen on the display means as a predetermined screen,
The blood analyzer according to claim 1, wherein the predetermined input is an operation of a main screen display means by an input means. The blood analyzer according to any one of claims 1 to 5 , wherein the measurement mode selection means can select at least a whole blood measurement mode and a dilution measurement mode. The main screen includes a measurement result display means for displaying the measurement screen on which the measurement result is displayed on the display means.
The blood analyzer according to any one of claims 1 to 6 , wherein the control unit causes the display unit to display a measurement screen on which the measurement result is displayed by operating the measurement result display unit. It has a printing means for printing the measurement results,
The blood analyzer according to any one of claims 1 to 7 , wherein the control unit causes the measurement unit to print the measurement result. The blood analyzer according to any one of claims 1 to 8 , wherein the input unit and the display unit are touch panel type input / display devices. The blood analyzer according to any one of claims 1 to 9 , wherein the predetermined period is a period from when the measurement result is displayed until the cleaning operation is completed. The blood analyzer according to any one of claims 1 to 9 , wherein the predetermined period is a period from when the measurement result is displayed until a predetermined time elapses.

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