JP5064159B2 - Optical tomographic imaging system - Google Patents

Description

  The present invention relates to an optical tomographic imaging apparatus that irradiates light to a measurement object and acquires a tomographic image of the measurement object from reflected light, a contact area detection method, and an image processing method using the same.

As a method for acquiring a cross-sectional image without cutting a measurement target such as a living tissue, there is an optical tomographic imaging apparatus using OCT (Optical Coherence Tomography) measurement.
This OCT measurement is a type of optical interferometry, in which the light emitted from the light source is divided into measurement light and reference light, and the optical path length of the measurement light and reference light is within the coherence length of the light source. This is a measurement method using the fact that optical interference is detected only when they match.

As an optical tomographic imaging apparatus using this OCT measurement, for example, Patent Document 1 discloses a light source, a first optical coupler unit that divides light emitted from the light source into measurement light and reference light, and measurement light. A measurement unit that irradiates a target and detects reflected light, a reference light that is guided along the same optical path length as the measurement light, a second coupler that causes reflected light to interfere, and a tomographic image is detected from the interference result There is an optical tomographic imaging apparatus having an arithmetic unit for performing the above.
In the optical tomographic imaging apparatus disclosed in Patent Literature 1, the optical fiber of the measurement unit is rotatably connected by a rotary joint, and a two-dimensional tomographic image is acquired by acquiring a tomographic image while rotating the optical fiber. . That is, a two-dimensional image is acquired by acquiring tomographic images of a plurality of points around the measurement point while rotating the optical fiber.

JP 2000-131222 A

The optical tomographic imaging apparatus of the cited document 1 is an apparatus that acquires a surrounding two-dimensional tomographic image by acquiring a tomographic image at each position while rotating a measurement unit provided at the tip of an optical fiber. A tomographic image inside a living body can be acquired by inserting a fiber into a bronchus, ureter, blood vessel, or the like and acquiring a tomographic image. Further, it is possible to obtain a tomographic image of the entire circumference of the measurement unit by rotating.
Here, such an optical tomographic imaging apparatus can acquire a two-dimensional tomographic image with high accuracy and high resolution by increasing the number of measurement points. By acquiring a high-resolution tomographic image, for example, when a tomographic image of a human body is acquired and used for diagnosis of a disease or the like, a more accurate and simple diagnosis can be performed.
However, since the amount of information to be processed increases as the number of measurement points increases, there is a problem that an expensive processing device with a high calculation speed is required and the device becomes expensive. In addition, there is a problem that the processing speed is reduced due to the increase in the amount of information, and it takes time to display the measurement result.

An object of the present invention is to provide an optical tomographic imaging apparatus capable of solving the problems based on the above prior art and producing a tomographic image with high resolution efficiently and easily.
Another object of the present invention is to provide a contact area detection method capable of easily detecting the state of an optical probe and easily detecting a highly accurate area of a tomographic image. .
Another object of the present invention is to provide an image processing method capable of acquiring a tomographic image that is efficient and simple and has high resolution and can be suitably used for diagnosis and the like.

  In order to solve the above-mentioned problem, the present inventors have conducted intensive studies, and as a result, the optical tomographic imaging apparatus detects a tomographic image of the entire circumference of the measurement unit, but does not contact the measurement unit. It was found that the image has low accuracy and resolution. Moreover, in order to acquire a highly accurate and high-resolution image, it discovered that a measurement part and a measuring object need to be in a contact or the state close | similar to a contact.

  Based on the above knowledge, in order to solve the above problems, the present inventors, as a first aspect of the present invention, as a first aspect of the present invention, a light source and a branching unit that branches light emitted from the light source into measurement light and reference light And an optical fiber that transmits the measurement light, disposed at the tip of the optical fiber, irradiates the measurement target with light, covers the outer periphery of the optical fiber and the measurement unit, A region where light is emitted from the measurement unit includes an optical probe including an outer cylinder formed of a transparent material, a drive unit that rotates the measurement unit and the optical fiber, and reflected light detected by the measurement unit. A multiplexing unit that multiplexes the reference light to generate interference light, an interference light detection unit that detects the interference light as an interference signal, and a distance between the optical probe and the measurement target from the detected interference signal And calculate the optical probe from the distance. There is provided an optical tomographic imaging apparatus having the a contact detection unit for detecting a contact area measured, the tomographic image acquisition unit that acquires a tomographic image from the detected the interference signal.

Here, it is preferable that the contact detection unit detects a contact state each time the measurement unit and the optical fiber are rotated a predetermined number of times by the driving unit.
Moreover, it is preferable that the said contact detection part detects the area | region where the distance of the calculated said optical probe and the said measuring object is below fixed as a contact state, and detects the said contact area | region from the detected result.
Furthermore, it is preferable to have a display unit that displays the tomographic image acquired by the tomographic image acquisition unit.
Moreover, it is preferable that the tomographic image acquisition unit acquires a tomographic image of only the contact area detected by the contact detection unit.
Furthermore, it is preferable to have an operation unit that changes the contact area detected by the contact detection unit.

Further, the optical path length adjusting unit is provided on the optical path of the reference light, and adjusts the optical path length of the reference light. It is preferable to generate interference light for each position in the vertical direction.
Alternatively, the interference light detection unit detects an interference signal for each spectral component of light, and the contact detection unit frequency-analyzes the interference signal and calculates a distance between the optical probe and the measurement target from the analysis result. Preferably, the tomographic image acquisition unit performs frequency analysis on the interference signal and acquires a tomographic image from the analysis result.

  Further, in order to solve the above-mentioned problem, as a second aspect of the present invention, a measurement unit provided at the tip of the optical probe that irradiates the measurement object with the measurement light and acquires the reflected light is rotated, A contact region detection method for detecting a contact state between an optical probe and a measurement target of an optical tomographic imaging apparatus that acquires a tomographic image of the measurement target from interference light obtained by combining the reflected light and the reference light acquired by the measurement unit. The measurement light is emitted from the measurement unit to obtain reflected light, the probe position acquisition step of detecting the outer peripheral position of the optical probe, and the measurement unit is rotated at the position to measure the measurement object, A measurement target position detecting step for emitting measurement light to obtain reflected light, detecting a position of the surface of the measurement target from the reflected light, and a distance detection step for detecting a distance between the measurement target and the outer periphery of the optical probe And before From the contact position determination step for determining that the optical probe is in contact with the measurement object in a region where the distance between the outer circumference of the optical probe and the surface of the measurement object is constant or less, and the result of determination in the contact position determination step A contact area detection method including a contact area detection step of detecting a contact area between an outer periphery of the optical probe and a surface of the contact target is provided.

Here, it is preferable that the measurement target position detection step detects a peak position outside the outer periphery of the optical probe where the intensity of the reflected light exceeds a certain threshold value as the surface of the measurement target.
Furthermore, it is preferable to have a distance setting step for setting a distance for determining that the object is in contact with the measurement object.

  In order to solve the above-mentioned problem, as a third aspect of the present invention, there is provided an image processing method for acquiring a tomographic image of a measurement object, wherein the contact region detection method according to any one of the above, A contact area setting step for detecting and setting a contact area with the measurement object; an interference signal for generating reflected light by rotating the measurement unit to generate the interference light and acquiring the interference light as an interference signal; There is provided an image processing method including an acquisition step and a tomographic image acquisition step of acquiring only a tomographic image by processing only the interference signal of the contact region detected in the contact region detection step.

  Furthermore, it is preferable to have a display step of displaying the acquired tomographic image on the screen by rotating and enlarging the range.

According to the present invention, an effective portion with high resolution can be detected by detecting the contact state between the measurement unit and the measurement object. As a result, the effective portion can be recognized and selectively processed.
Furthermore, the processing amount of information can be reduced by processing only the contact area determined to be in contact with the measurement unit and the measurement object. In addition, it detects the presence or absence of contact between the measurement unit and the measurement target, and does not process the information of the area that becomes a low-priority, low-reliability tomographic image. By processing in this manner, the amount of processing information can be reduced, and a high-quality and high-quality tomographic image can be read.

  A contact region detection method, an image processing method using the contact region detection method, and an optical tomographic imaging apparatus according to the present invention will be described in detail based on embodiments shown in the accompanying drawings.

  FIG. 1 is a block diagram showing a schematic configuration of an optical tomographic imaging apparatus 10 of an embodiment of the optical tomographic imaging apparatus of the present invention using the contact area detection method and the image processing method of the present invention. FIG. 3 is an enlarged partial cross-sectional view showing a distal end portion of the optical probe 16 of the optical tomographic imaging apparatus 10 shown in FIG. 1, and FIG. 3 shows a schematic configuration of the processing unit 24 of the optical tomographic imaging apparatus 10 shown in FIG. FIG.

As shown in FIG. 1, the optical tomographic imaging apparatus 10 includes a light source unit 12 that emits light, branches light emitted from the light source unit 12 into measurement light and reference light, and also reflects reflected light and reference light. A branching / combining unit 14 that generates interference light by multiplexing, an optical probe 16 that guides measurement light to irradiate the measurement target, and obtains reflected light from the measurement target, and adjusts the optical path length of the reference light An optical path length adjusting unit 18, an interference light detecting unit 20 that detects the interference light generated by the branching and multiplexing unit 14 as an interference signal, and a processing unit 22 that processes the interference signal detected by the interference light detecting unit 20. And a display unit 24 for displaying the optical tomographic image acquired by the processing unit 22 (hereinafter also simply referred to as “tomographic image”). Furthermore, the optical tomographic imaging apparatus 10 includes a rotation drive unit 26 that rotates a measurement unit of the optical probe, an optical fiber coupler 28 that splits light emitted from the light source unit 12, and a detection unit 30a that detects reference light. And a detection unit 30b that detects reflected light, and an operation control unit 32 that inputs various conditions to the processing unit 22 and the display unit 24, changes settings, and the like. Further, an optical fiber is used as a light path, and measurement light, reference light, reflected light, and the like are guided to each part.
Hereinafter, each part will be described in detail.

  The light source unit 12 includes a semiconductor optical amplifier 40, an optical splitter 42, a collimator lens 44, a diffraction grating element 46, an optical system 48, and a rotary polygon mirror 50, and the frequency is swept at a constant period. A laser beam La is emitted.

The semiconductor optical amplifier (semiconductor gain medium) 40 emits weak emission light and amplifies incident light when a drive current is applied. An optical fiber FB10 is connected to the semiconductor optical amplifier 40. Specifically, one end of the optical fiber FB10 is connected to a portion where light is emitted from the semiconductor optical amplifier 40, and the other end of the optical fiber FB10 is connected to a portion where light enters the semiconductor optical amplifier 40. The light emitted from the semiconductor optical amplifier 40 is emitted to the optical fiber FB10 and enters the semiconductor optical amplifier 40 again.
Thus, by forming a loop of the optical path with the semiconductor optical amplifier 40 and the optical fiber FB10, the semiconductor optical amplifier 40 and the optical fiber FB10 become an optical resonator, and a drive current is applied to the semiconductor optical amplifier 40. Pulsed laser light is generated.

The optical splitter 42 is provided on the optical path of the optical fiber FB10 and is also connected to the optical fiber FB11. The optical branching device 42 branches a part of the light guided in the optical fiber FB10 to the optical fiber FB11.
The collimator lens 44 is disposed at the other end of the optical fiber FB11, that is, the end not connected to the optical fiber FB10, and makes the light emitted from the optical fiber FB11 parallel light.
The diffraction grating element 46 is disposed at a predetermined angle on the optical path of the parallel light generated by the collimator lens 44. The diffraction grating element 46 splits the parallel light emitted from the collimator lens 44.
The optical system 48 is disposed on the optical path of the light split by the diffraction grating element 46. The optical system 48 is composed of a plurality of lenses, refracts the light split by the diffraction grating element 46, and converts the refracted light into parallel light.
The rotating polygon mirror 50 is disposed on the optical path of the parallel light generated by the optical system 48 and reflects the parallel light. The rotating polygon mirror 50 is a rotating body that rotates at a constant speed in the R1 direction in FIG. 1. A surface perpendicular to the rotation axis is a regular octagon, and a side surface (each side of the octagon is irradiated with parallel light). Surface) is formed of a reflecting surface that reflects the irradiated light.
The rotating polygon mirror 50 rotates to change the angle of each reflecting surface with respect to the optical axis of the optical system 48.

The light emitted from the optical fiber FB11 passes through the collimator lens 44, the diffraction grating element 46, and the optical system 48, and is reflected by the rotary polygon mirror 50. The reflected light passes through the optical system 48, the diffraction grating element 46, and the collimator lens 44 and enters the optical fiber FB11.
Here, as described above, since the angle of the reflecting surface of the rotating polygon mirror 50 changes with respect to the optical axis of the optical system 48, the angle at which the rotating polygon mirror 50 reflects light changes with time. For this reason, only the light in a specific frequency region out of the light dispersed by the diffraction grating element 46 is incident on the optical fiber FB11 again. Here, since the light in a specific frequency range incident on the optical fiber FB11 is determined by the angle between the optical axis of the optical system 48 and the reflecting surface of the rotary polygon mirror 50, the frequency range of the light incident on the optical fiber FB11 is It changes depending on the angle between the optical axis of the optical system 48 and the reflecting surface of the rotary polygon mirror 50.

The light in a specific frequency range that has entered the optical fiber FB11 is incident on the optical fiber FB10 from the optical splitter 42, and is combined with the light in the optical fiber FB10. Thereby, the pulsed laser light guided to the optical fiber FB10 becomes laser light in a specific frequency range, and the laser light La in the specific frequency range is emitted to the optical fiber FB1.
Here, since the rotary polygon mirror 50 is rotating at a constant speed in the direction of the arrow R1, the wavelength λ of the light incident on the optical fiber FB11 again changes with a constant period as time passes. As a result, the frequency of the laser light La emitted to the optical fiber FB1 also changes at a constant period with the passage of time.

  The light source unit 12 has such a configuration, and emits the laser light La swept in wavelength toward the optical fiber FB1.

Next, the branching / combining unit 14 is configured by, for example, a 2 × 2 optical fiber coupler, and is optically connected to the optical fiber FB1, the optical fiber FB2, the optical fiber FB3, and the optical fiber FB4, respectively.
The branching / combining unit 14 divides the light La incident from the light source unit 12 through the optical fiber FB1 into the measurement light L1 and the reference light L2, and causes the measurement light L1 to enter the optical fiber FB2, and the reference light L2 is emitted as light. The light is incident on the fiber FB3.
Further, the branching / combining unit 14 is incident on the optical fiber FB3, and after the frequency shift and the optical path length are changed by the optical path length adjusting unit 18 to be described later, returns to the optical fiber FB3 and enters the branching / multiplexing unit 14 The reference light L2 obtained and the reflected light L3 from the measuring object S, which is acquired by the optical probe described later and is incident on the branching / combining unit 14 from the optical fiber FB2, are combined and emitted to the optical fiber FB4.

The optical probe 16 is connected to the optical fiber FB2 via the rotation drive unit 26, and the measurement light L1 is incident from the optical fiber FB2, and the measurement light S1 is irradiated to the measurement target S. The reflected light L3 from is acquired, and the acquired reflected light L3 is emitted to the optical fiber FB2.
As shown in FIG. 2, the optical probe 16 includes a probe outer cylinder 52, a cap 54, an optical fiber 56, a spring 58, a fixing member 60, and an optical lens 62.

The probe outer cylinder (sheath) 52 is a cylindrical member having flexibility, and is made of a material through which the measurement light L1 and the reflected light L3 are transmitted. The probe outer cylinder 52 is made of a material (that is, transparent) at which part of the tip (end opposite to the side where the optical fiber FB2 is disposed) through which the measurement light L1 and the reflected light L3 pass is transmitted. It is only necessary that the material is made of any material.
The cap 54 is provided at the tip of the probe outer cylinder 52 (the end opposite to the side where the optical fiber FB2 is disposed), and closes the tip of the probe outer cylinder 52.

The optical fiber 56 is a linear member, is accommodated in the probe outer cylinder 52 along the probe outer cylinder 52, guides the measurement light L1 emitted from the optical fiber FB2 to the optical lens 62, and performs measurement. The reflected light L3 from the measuring object S acquired by the optical lens 62 is guided to the optical fiber FB2 by irradiating the measuring object S with the light L1.
Here, the optical fiber 56 and the optical fiber FB2 are connected by a rotary joint or the like, and are optically connected in a state where the rotation of the optical fiber 56 is not transmitted to the optical fiber FB2. Further, the optical fiber 56 is disposed in a state of being rotatable with respect to the probe outer cylinder 52.
The spring 58 is fixed to the outer periphery of the optical fiber 56. The optical fiber 56 and the spring 58 are connected to the rotation drive unit 26.

The optical lens 62 is disposed at the distal end of the optical fiber 56 (the end opposite to the side connected to the optical fiber FB2), and the distal end receives the measurement light L1 emitted from the optical fiber 56. In order to collect light with respect to the measuring object S, it is formed in a substantially spherical shape.
The optical lens 62 irradiates the measuring object S with the measuring light L 1 emitted from the optical fiber 56, collects the reflected light L 3 from the measuring object S, and enters the optical fiber 56.
The fixing member 60 is disposed on the outer periphery of the connection portion between the optical fiber 56 and the optical lens 62, and fixes the optical lens 62 to the end portion of the optical fiber 56. Here, the fixing method of the optical fiber 56 and the optical lens 62 by the fixing member is not particularly limited. Even if the fixing member, the optical fiber 56 and the optical lens 62 are bonded and fixed by an adhesive, a machine using a bolt or the like is used. It may be fixed with a mechanical structure.

  The rotation driving unit 26 is connected to the optical fiber 56 and the spring 58, and rotates the optical fiber 56 and the spring 58 to rotate the optical lens 62 in the direction of the arrow R2 with respect to the probe outer cylinder 11. The rotation drive unit 26 includes a rotation encoder (not shown), and detects the irradiation position of the measurement light L1 from the position information (angle information) of the optical lens 62 based on a signal from the rotation encoder. That is, the measurement position is detected by detecting the angle of the rotating optical lens 62 with respect to the reference position in the rotation direction.

The optical probe 10 is configured as described above, and the measurement light L1 emitted from the optical lens 62 is measured by rotating the optical fiber 56 and the spring 58 in the direction of the arrow R2 in FIG. The target S is irradiated while scanning in the direction of arrow R1 (circumferential direction of the probe outer cylinder 52), and the reflected light L3 is acquired.
Thereby, the reflected light L3 reflected from the measuring object S can be acquired over the entire circumference of the probe outer cylinder 52 in the circumferential direction.

The optical path length adjusting unit 18 is arranged on the reference light L2 emission side of the optical fiber FB3 (that is, the end of the optical fiber FB3 opposite to the branching / combining unit 14).
The optical path length adjustment unit 18 includes a first optical lens 64 that converts the light emitted from the optical fiber FB3 into parallel light, a second optical lens 66 that condenses the light converted into parallel light by the first optical lens 64, and A reflection mirror 68 that reflects the light collected by the second optical lens 66, a base 70 that supports the second optical lens 66 and the reflection mirror 68, and the base 70 are moved in a direction parallel to the optical axis direction. And a mirror drive mechanism 72, and adjusts the optical path length of the reference light L2 by changing the distance between the first optical lens 64 and the second optical lens 66.

The first optical lens 64 converts the reference light L2 emitted from the core of the optical fiber FB3 into parallel light, and condenses the reference light L2 reflected by the reflection mirror 68 on the core of the optical fiber FB3.
The second optical lens 66 condenses the reference light L2 made parallel by the first optical lens 64 on the reflection mirror 68, and makes the reference light L2 reflected by the reflection mirror 68 parallel. Thus, the first optical lens 64 and the second optical lens 66 form a confocal optical system.
The reflection mirror 68 is disposed at the focal point of the light collected by the second optical lens 66 and reflects the reference light L2 collected by the second optical lens 66.

  As a result, the reference light L2 emitted from the optical fiber FB3 becomes parallel light by the first optical lens 64 and is condensed on the reflection mirror 68 by the second optical lens 66. Thereafter, the reference light L2 reflected by the reflecting mirror 68 becomes parallel light by the second optical lens 66, and is condensed on the core of the optical fiber FB3 by the first optical lens 64.

The base 70 fixes the second optical lens 66 and the reflection mirror 68, and the mirror moving mechanism 72 moves the base 70 in the optical axis direction of the first optical lens 64 (direction of arrow A in FIG. 1). .
The distance between the first optical lens 64 and the second optical lens 66 can be changed by moving the base 70 in the arrow A direction by the mirror moving mechanism 72, and the optical path length of the reference light L2 can be adjusted. Can do.

The interference light detection unit 20 is connected to the optical fiber FB4, and detects the interference light L4 generated by combining the reference light L2 and the reflected light L3 by the branching / combining unit 14 as an interference signal.
Here, the optical tomographic imaging apparatus 10 is provided in an optical fiber coupler 28 that branches the laser light La from the optical fiber FB1 to the optical fiber FB5, and an optical fiber FB5 that is branched from the optical fiber coupler 28. It has a detector 30a for detecting the light intensity of the light La, and a detector 30b for detecting the light intensity of the interference light L4 on the optical path of the optical fiber FB4.
The interference light detection unit 20 adjusts the balance of the light intensity of the interference light L4 detected from the optical fiber FB4 based on the detection results of the detectors 30a and 30b.

From the interference signal detected by the interference light detection unit 20, the processing unit 22 is a region where the optical probe 16 and the measurement target S are in contact at the measurement position, more precisely, the surface of the probe outer cylinder 52 of the optical probe 16. A region that can be considered to be in contact with the surface of the measuring object S is detected, and a tomographic image is acquired from the interference signal detected by the interference light detection unit 20.
As illustrated in FIG. 3, the processing unit 22 includes an interference signal acquisition unit 80, an A / D conversion unit 82, a contact area detection unit 84, a tomographic image generation unit 86, and an image correction unit 88.

The interference signal acquisition unit 80 acquires the interference signal detected by the interference light detection unit 20, and further, information on the measurement position detected by the rotation drive mechanism 26, specifically, the position of the optical lens 62 in the rotation direction. The position information of the measurement position detected from the information is acquired, and the interference signal is associated with the position information of the measurement position.
Here, FIG. 4 is an explanatory diagram for explaining the position information of the measurement position of the optical probe.
In the present embodiment, the number of measurements per rotation of the optical lens 62 is determined from the rotational speed of the optical lens 62 and the cycle of sweeping the frequency of the measurement light L1. In the present embodiment, the interference signal is acquired 1024 times while the optical lens 62 rotates once. Further, the rotation of the optical lens 62 and the acquisition of the interference signal (that is, the scanning cycle of the measurement light L1) are constant.
Therefore, as shown in FIG. 4, the position of the measurement light L1, that is, the measurement position, moves from the rotation center by a predetermined angle in order from n = 1. Since the position where the interference signal is acquired in this way moves by a predetermined angle, the line number n can be associated with the measurement position of each interference signal. Since the optical lens 62 is rotating, the measurement position n = 1024 and the measurement position n = 1 are adjacent to each other.
The interference signal associated with the position information of the measurement position is sent to the A / D conversion means 82.

The A / D conversion unit 82 converts the interference signal output as an analog signal associated with the position information of the measurement position by the interference signal acquisition unit 80 into a digital signal.
The interference signal that is associated with the position information of the measurement position and digitally converted is sent to the contact area detection means 84 and the tomographic information refinement generation means 86.

  The contact area detection unit 84 applies an FFT (Fast Fourier Transform) to the interference signal converted into a digital signal by the A / D conversion unit 82, acquires the relationship between the frequency component and the intensity of the interference signal, and detects the detected frequency component and intensity. Is associated with the depth direction (the direction away from the rotation center), and information on the relationship between the depth direction and the intensity is acquired. The contact area detection means 84 determines the position of the surface of the probe outer cylinder 52 at the position where the measurement light L1 is transmitted (hereinafter referred to as “position of the probe outer periphery”) and the measurement light L1 from the information on the relationship between the depth direction and intensity. The contact region between the probe outer cylinder 52 and the measuring object S at the position where the light is transmitted is detected.

The detection of the position of the probe outer periphery will be described.
First, information on the relationship between the frequency component and the intensity obtained by subjecting the interference signal for an arbitrary line to the FFT is further processed to obtain information on the relationship between the depth direction and the intensity. FIG. 5 is a graph showing a schematic example of a calculation result obtained by performing FFT on an interference signal. Here, in FIG. 5, the horizontal axis is the depth direction, and the vertical axis is the strength.
As shown in FIG. 5, a portion where the intensity is high and a position where a peak of intensity (hereinafter simply referred to as “peak”) is detected are positions where the physical properties have changed. That is, it is a boundary position between air and a substance, or a substance and another characteristic substance. Here, the definition of the peak is not particularly limited, and various settings can be made, for example, when the intensity becomes a certain value or more, or when the intensity change amount becomes more than a certain value.
Here, since the substance that reflects the measurement light L1 emitted from the optical lens 62 at the closest position is the probe outer cylinder 52, the peak detected at the first peak position, that is, the position closest to the optical lens 62 is detected. (Peak P1 in FIG. 5) is the position of the outer periphery of the probe.
The optical lens 62 and the probe outer cylinder 52 are arranged concentrically around the rotation center. For this reason, since the position of the rotation center of the optical lens 62 and the position of the probe outer circumference are a constant distance regardless of the measurement position, the position of the probe outer circumference detected by one line can be set as the position of the outer circumference of the probe. it can.
In this way, the contact area detecting means 84 detects the position of the probe outer periphery.

  Next, detection of a contact area between the probe outer cylinder 52 and the measurement target S at a position where the measurement light L1 is transmitted (hereinafter simply referred to as “contact area between the probe outer cylinder 52 and the measurement target S”) will be described.

First, similarly to the detection of the position of the probe outer periphery, the interference signal for one line is subjected to FFT to acquire information in the depth direction.
As the detection result, a plurality of peaks are detected in the depth direction, as in the graph shown in FIG.
Among the plurality of detected peaks, the first peak (peak P1 in FIG. 5) is the peak at which the probe outer cylinder is detected, and the peak closest to the peak at which this probe outer cylinder is detected (in FIG. 5). , Peak P2) is the surface of the measurement object. That is, the peak position at the position closest to the center of rotation (the second shallowest position) is the position of the surface of the measuring object S.

  Next, the distance between the detected surface of the measuring object S and the outer periphery of the probe is detected. If the detected distance is equal to or smaller than the threshold, it is determined that the measuring object S and the outer periphery of the probe are in contact with each other. When larger, it determines with the measuring object S and probe outer periphery being a non-contact state.

Next, in the same manner for the adjacent line, the interference signal is subjected to FFT, the peak closest to the peak where the probe outer cylinder is detected is detected as the position of the surface of the measuring object S, and the surface of the measuring object S and the probe periphery are detected. Is detected, and it is determined whether or not it is in a contact state.
Such determination is performed for each line, and the contact state between the measurement target S and the probe outer periphery is determined over the entire circumference of the measurement region.

Next, the contact area between the probe outer cylinder 52 and the measurement target S is detected based on the determination result of the contact state between the measurement target S and the outer periphery of the probe.
This will be specifically described with reference to FIG. 6A and 6B are explanatory diagrams for explaining a method of detecting a contact area. Here, a circle C1 shown in FIGS. 6A and 6B is a circle indicating the outer periphery of the probe.
As shown in FIG. 6A, the surfaces S1 and S2 of the measuring object S are detected by detecting the peaks around the entire circumference. Here, the surface S <b> 1 has a portion where the probe outer cylinder 52 and the measuring object S are in contact with each other, and other regions including the surface S <b> 2 are located away from the probe outer cylinder 52.
In such a case, as shown in FIG. 6 (B), the contact area detecting means 84 uses a region D1 in a certain range centered on the contacting portion of the surface S1 between the probe outer cylinder 52 and the measuring object S. Detect as a contact area.
The detected contact area between the probe outer cylinder 52 and the measuring object S is sent to the tomographic information generation means 86.

The tomographic information acquisition means 86 processes the information on the relationship between the frequency component and the intensity acquired by subjecting the interference signal converted into a digital signal by the A / D conversion means 82 to FFT (Fast Fourier Transform), and thereby in the depth direction. Acquire a tomographic image.
Here, the tomographic information acquisition unit 86 acquires a tomographic image of only the interference signal of the position information determined as the contact area from the contact area information sent from the contact area detection means 88, and acquires the position information other than the contact area. The interference signal does not acquire a tomographic image, that is, performs mask processing without performing image acquisition processing from the result of applying FFT or FFT.

  Here, generation of an image in the tomographic information acquisition unit 86 will be briefly described. Details of this point are described in “Mitsuo Takeda,“ Optical Frequency Scanning Spectrum Interference Microscope ”, Optical Technology Contact, 2003, Vol41, No7, p426-p432”.

When the measurement light L1 is irradiated onto the measurement object S, interference fringes with respect to each optical path length difference l when the reflected light L3 from the depth of the measurement object S and the reference light L2 interfere with each other with various optical path length differences. Is S (l), the light intensity I (k) of the interference signal detected by the interference light detector 20 is
I (k) = ∫ ₀ ^∞ S (l) [1 + cos (kl)] dl
It is represented by Here, k is the wave number, and l is the optical path length difference. It can be considered that the above equation is given as an interferogram in the optical frequency domain with the wave number k = ω / c as a variable. For this reason, the tomographic information acquisition means 86 performs fast Fourier transform on the spectral interference fringes detected by the interference light detection unit 20, and determines the light intensity S (l) of the interference light L4, thereby starting measurement of the measurement object S. The distance information from the position and the reflection intensity information can be acquired and a tomographic image can be generated.

The image correcting unit 88 performs logarithmic transformation and radial transformation on the tomographic image generated by the tomographic image generating unit 86, arranges them in the order of line numbers, and forms a circular image centered on the rotation center of the optical lens.
Further, the image correcting unit 88 corrects the image quality by performing a sharpening process, a smoothing process, or the like on the tomographic image.
The image correcting unit 88 transmits the tomographic image subjected to the image quality correction to the display unit 24.
Here, the transmission timing of the tomographic image is not particularly limited, and it may be transmitted to the display unit every time processing of one line is finished, and may be rewritten and displayed for each line. The image may be transmitted at the stage where the processing of the image acquired by making one round is completed and one circular tomographic image is formed.

The display unit 24 is a CRT, a liquid crystal display device, or the like, and displays the tomographic image transmitted from the image correction unit 88.
The operation control unit 32 includes input means such as a keyboard and a mouse, and control means for managing various conditions based on the input information, and is connected to the processing unit 22 and the display unit 24. The operation control unit 32 inputs, sets, and changes the above-described threshold value and various processing conditions of the processing unit 22 and changes the display setting of the display unit 24 based on an operator instruction input from the input force means. Do. The operation control unit 32 may display the operation screen on the display unit 24 or may provide a separate display unit. Further, the operation control unit 32 may perform operation control of the light source unit 12, the optical path length adjustment unit 18, the interference light detection unit 20, the rotation drive unit 26, and the detection units 30a and 30b, and setting various conditions.
The optical tomographic imaging apparatus 10 is basically configured as described above.

Next, by describing the operation of the optical tomographic imaging apparatus 10, in addition to the optical tomographic imaging apparatus of the present invention, a contact area detection method and an image processing method will also be described.
First, a method for acquiring interference light and interference signals obtained by measuring the measurement object S will be described.
First, the optical path length is adjusted and set so that the measuring object S is positioned in the measurable region by moving the base 70 in the arrow A direction by the mirror driving mechanism 72.

Thereafter, the laser light La is emitted from the light source unit 12. The emitted laser light La is split into measurement light L1 and reference light L2 by the branching / combining unit 14. The measurement light L1 is guided through the optical fiber FB2 and the optical probe 16, and is irradiated onto the measurement object S.
Then, the light reflected at each depth position of the measuring object S enters the optical probe 10 as reflected light L3. The reflected light L3 is incident on the branching / combining unit 14 via the optical probe 16 and the optical fiber FB2.
On the other hand, the reference light L2 is incident on the optical path length adjusting unit 18 through the optical fiber FB3. Then, the reference light L <b> 2 whose optical path length is adjusted by the optical path length adjusting unit 18 is guided again through the optical fiber FB <b> 3 and is incident on the branching / combining unit 14.
Then, the branching / multiplexing unit 14 combines the reflected light L3 from the measurement target S with the reference light L2 whose optical path length is adjusted by the optical path length adjusting unit 18. Interference light L4 between the reflected light L3 and the reference light L2 is generated. The interference light is detected as an interference signal by the interference light detection unit 20.
The interference light and the interference signal are detected as described above.

Hereinafter, a method for processing the interference light detected by the above method will be described.
FIG. 7 is a flowchart showing a method for detecting the position of the probe outer periphery, FIG. 8 is a flowchart showing a method for detecting a contact area, and FIG. 9 calculates a tomographic image based on the detected contact area. It is a flowchart which shows an image processing method.

A method for detecting the position of the outer periphery of the probe will be described with reference to FIG.
First, an interference signal for an arbitrary line is acquired (step S10). Specifically, the interference light detection unit 20 detects the interference light L4 generated by combining the reference light L2 and the reflected light L3 by the method described above as an interference signal.
Next, the detected interference signal is A / D converted (step S12). More specifically, the A / D conversion means 82 converts an analog interference signal into a digital signal.
Next, FFT is applied to the A / D converted interference signal to obtain information on the relationship between the frequency component and the intensity, and further processing is performed to obtain the relationship between the depth direction and the intensity, thereby detecting the peak position. (Step S14). Here, as described above, the peak position is a position where light is reflected, and is basically a boundary surface of the substance.
The position of the outer periphery of the probe is detected from the detected peak position (step S16).
Specifically, the peak detected at the position closest to the optical lens 62 among the peak positions is detected as the position of the probe outer periphery.
In this way, the position of the outer periphery of the probe is detected.

Next, a method for detecting a contact area between the probe outer cylinder 52 and the measuring object S will be described with reference to FIG.
First, the line number n is set to n = 1 (step S20). Here, the line number is a number given in the order of the measurement position of the interference signal with reference to an arbitrary line. Therefore, in the present embodiment in which the interference signal is detected 1024 times during one rotation of the optical lens 62, lines numbered from 1 to 1024 are arranged at equal intervals (see FIG. 4 described above).

Next, the interference signal of the line number n is acquired (step S22). Specifically, the interference light L4 generated by combining the reference light L2 and the reflected light L3 by the method described above is used as an interference signal. Detection is performed by the light detection unit 20. Here, the line number can be determined by the position information associated with the interference signal by the interference signal acquisition means 80.
If the line number of the acquired interference signal is not n, the acquisition of the interference signal is repeated until the interference signal of line number n is detected.

Next, the detected interference signal is A / D converted (step S24). More specifically, the A / D conversion means 82 converts an analog interference signal into a digital signal.
Next, the A / D converted interference signal is subjected to FFT to detect the peak position (step S26). Here, as described above, the peak position is a position where light is reflected, and is basically a boundary surface of the substance.

The position of the surface of the measuring object S is detected from the detected peak position (step S28).
Here, since no other object basically intervenes between the measuring object S and the optical probe 16, the peak at the position closest to the position where the probe outer cylinder detected in step S16 is detected, that is, the rotation center. The peak position at the second closest position (the second shallowest position) is detected as the position of the surface of the measuring object S.

Next, the distance between the detected surface of the measuring object S and the outer periphery of the probe is detected, and it is determined whether the detected distance is equal to or less than the threshold value X (S30).
If the detected distance is less than or equal to the threshold value X, it is determined that the measuring object S and the probe outer periphery are in contact (step S32), and the process proceeds to step S36. If the detected distance is greater than the threshold value X, the measuring object S and It determines with a probe outer periphery being a non-contact state (step S34), and progresses to step S36.

Next, it is determined whether the line number n is N (step S36).
Here, N is the total number of lines (that is, the number of all lines), and N = 1024 in this embodiment.

When the line number n is not N, n = n + 1 is set (step S38), and the process proceeds to step S22. After n is increased by 1, the process proceeds to step S22 to determine whether or not there is contact between the probe periphery of the next line number and the measurement target.
On the other hand, if the line number n is N, the contact determination for each line ends, and a contact range table is created (step S40).
Here, the contact range table detects a region within a predetermined range centered on the region determined to be in contact. For example, when it is determined that line numbers (a + 10) to (b-30) are in contact, the line number a to line number b is set as the contact area. The contact range table setting method is determined based on preset setting conditions.
In this way, the contact range table is created, and the process ends.
The contact area between the probe outer periphery and the measurement object is detected as described above.

Next, an image processing method for creating a tomographic image will be described with reference to FIG.
First, an interference signal of line number n that is an arbitrary line number is acquired (step S50). Specifically, the interference light detection unit 20 detects the interference light L4 generated by combining the reference light L2 and the reflected light L3 by the method described above as an interference signal.

Next, the detected interference signal is A / D converted (step S52). More specifically, the A / D conversion means 82 converts an analog interference signal into a digital signal.
Next, it is determined whether or not the line number n is included in the contact range table created in step S40, that is, whether or not the line number n is included between the line number a and the line number b that is the contact area (step S54). That is, it is determined whether or not a ≦ n ≦ b.
If the line number n satisfies a ≦ n ≦ b, the A / D converted interference signal is subjected to FFT (step S56).
Next, a tomographic image of line number n is acquired from the result of applying FFT (step S58).
Here, as described above, the tomographic image is subjected to predetermined processing based on the result of the FFT, and an image is acquired.
If a tomographic image is acquired, the process proceeds to step S62.

On the other hand, if the line number n does not satisfy a ≦ n ≦ b, that is, if n <a or b <n, masking processing is performed (step S60).
Here, the masking processing does not perform processing for acquiring the FFT and the tomographic image, and sets the image of the line number n as a black image or a fixed image.
When the masking process ends, the process proceeds to step S62.

Next, it is determined whether or not there is an end instruction (step S62).
If there is no end instruction, n = n + 1 is set (step S64), and then the process proceeds to step S50. After n is increased by 1, the process proceeds to step S50 to perform a process of acquiring a tomographic image of the next line number. Although illustration is omitted, when n = N + 1, n is set to 1 and the tomographic image acquisition is continued until an end instruction is given.
If there is an end instruction, the process ends.
As described above, a tomographic image to be measured is acquired.

  The image information and tomographic image of the mask-processed area obtained in this way are sent to the image correction means, and image processing for display such as radial processing and sharpening processing is performed. Thereafter, the image is sent to the display unit 24 and displayed on the display unit 24.

According to the present invention, it is possible to detect and recognize a region where a tomographic image is detected with high resolution by detecting the contact region between the measurement target and the optical probe by the contact region detecting means. As a result, it is possible to process only a highly reliable and high-resolution area as in this embodiment.
In this embodiment, the mask process is performed on areas other than the contact area. However, the present invention is not limited to this, and the image processing method may be changed between the contact area and other areas. For example, a tomographic image of all lines may be acquired for the contact area, and a tomographic image may be acquired for each fixed line number except for the contact area. Further, according to the detection result of the contact area, the rotation speed and the rotation direction of the optical fiber 56 and the optical lens 62 by the rotation drive unit 26 are controlled, for example, by reciprocating only the contact area to acquire a tomographic image, The area other than the contact area may be moved at high speed.
Further, the present invention is not limited to using the detection result of the contact area for acquiring a tomographic image. For example, the contact area may be displayed overlaid on the displayed tomographic image, and the reliability of the tomographic image and the distance from the measurement target are calculated from the contact state and the contact area and displayed together with the tomographic image. May be. By detecting the contact area and displaying the result, the operator can easily recognize the area with high resolution.
By detecting the contact area in this way, the effectiveness of the tomographic image portion can be easily determined.

In addition, the area for acquiring the tomographic image is limited to the area corresponding to the contact area, and the other areas are not subjected to image processing, thereby reducing the burden on the processing unit and reducing the processing time. can do. Thereby, even when an inexpensive arithmetic processing unit (processor) is used, high-speed moving image display can be performed. The apparatus can be made inexpensive while displaying a high-resolution tomographic image.
In addition, based on the contact area, it does not acquire the image processing of the measurement object in the area that is separated from the optical probe, the resolution is low, and the image is unclear and difficult to use as a tomographic image. Since the tomographic image of the contact area that is the area to be acquired is acquired, the tomographic image can be used effectively. Further, by limiting the area where image processing is performed to only the contact area, it is possible to perform advanced image processing using the tomographic image without increasing the total amount of information processing.

Here, the method for setting the range of the contact range table and the method for setting the contact region are not particularly limited, and it may be set so that only the line below the threshold is detected as the contact region, and it is determined that the contact is made. It is also possible to set so that a region where a plurality of lines are continuous is detected as a contact region. Further, the width of the contact area, that is, the number of lines may be set.
In the present embodiment, the contact area is a single area. However, a plurality of contact areas can also be detected. In this case as well, the range of line numbers serving as the contact areas is divided into a plurality of areas. It can be performed.
Furthermore, the threshold value for determining whether or not the probe outer cylinder is in contact with the measurement target may be an arbitrary value, and the setting may be changed according to an operator input or a condition.

In addition, it is preferable to provide an increase instruction unit that increases the contact area to a certain area, that is, a predetermined number of lines when tomographic images are acquired. Here, the increase instruction unit may be newly provided as a specific button, or may be provided in a part of the operation control unit.
By making it possible to increase the contact area with the increase instruction unit, it is possible to cope with the case where the operator wants to confirm the peripheral part of the tomographic image currently acquired, and to provide the information desired by the operator suitably Can do.
Moreover, it is preferable that the operation control part can change and increase the area | region which acquires a tomographic image.
Thereby, in addition to the detection result of the contact area, a tomographic image of an area desired by the operator can be acquired.

  In the present embodiment, the measurement position by the measurement light is calculated from the encoder of the rotation drive unit, but the present invention is not limited to this. For example, since one cycle of the laser beam emitted from the light source and swept at a predetermined cycle is one line of the interference signal, the number of lines is detected from the cycle of the laser beam, and the measurement position from the reference position is determined by the number of lines. You may make it calculate.

Further, in the present embodiment, the surface position of the measurement target is detected in all lines, but the present invention is not limited to this, and the surface position of the measurement target is detected in every predetermined line, for example, even lines or multiples of three. The contact area may be detected. Thus, by reducing the number of lines to be detected, the amount of information processing can be reduced, and the processing speed can be increased. Moreover, since the contact area can set the periphery of the line determined to be in the contact state as the contact area, the contact area can be appropriately detected even by detection for each predetermined line.
In this embodiment, the process is started from the line number n = 1. However, the start position is not particularly limited as long as the entire circumference of the probe outer circumference can be detected.
Further, in the present embodiment, the outer periphery of the probe is calculated based on the detection result of only one line, but it may be detected by a plurality of lines and the average value of the calculated results may be used as the position of the outer periphery of the probe.

Here, the timing of detecting the contact area between the probe outer cylinder and the measurement target is not particularly limited, and even if the rotation drive unit detects the contact area every time the optical lens and the optical fiber are rotated a certain number of times, The contact area may be detected when there is a detection instruction.
Here, by detecting the contact area every time the optical lens and the optical fiber are rotated a certain number of times, it is possible to automatically recognize the high resolution area, and to respond quickly even when the contact area changes. it can.

When acquiring a tomographic image of only the contact area and displaying it on the display unit, the image correcting means may rotate the display position of the tomographic image part to a position that can be easily confirmed by the operator. May be enlarged.
Thus, by performing the process of rotating and enlarging the tomographic image and displaying it on the display unit, the operator can easily confirm the tomographic image.

  In the optical tomographic imaging apparatus 10, the tomographic image of the measurement target is acquired by SS-OCT (swept source-OCT) measurement and the contact area with the measurement target is detected, but the present invention is not limited to this.

FIG. 10 is a block diagram schematically showing a schematic configuration of another embodiment of the optical tomographic imaging apparatus.
Here, the optical tomographic imaging apparatus 100 shown in FIG. 10 obtains a tomographic image of a measurement target by SD-OCT (spectral domain-OCT) measurement, and detects a contact area with the measurement target. Since the other configuration is the same as that of the optical tomographic imaging apparatus 10, the same components are denoted by the same reference numerals, and detailed description thereof will be omitted. Will be described.

  The optical tomographic imaging apparatus 10 splits light emitted from the light source unit 102 that emits light and the light source unit 12 into measurement light and reference light, and combines reflected light and reference light to generate interference light. A branching / multiplexing unit 14, an optical probe 16 that guides measurement light and irradiates the measurement target, and further reflects reflected light from the measurement target, an optical path length adjustment unit 18 that adjusts the optical path length of the reference light, and a branch An interference light detection unit 104 that detects interference light generated by the multiplexing unit 14, a processing unit 22 that processes the detection result detected by the interference light detection unit 20, and a tomographic image acquired by the processing unit 22 are displayed. Display unit 24. Further, the optical tomographic imaging apparatus 10 includes a rotation drive unit 26 that rotates a measurement unit and the like of an optical probe, and an operation input unit 32 that inputs various conditions to the processing unit 22 and the display unit 24 and changes settings. Have Further, an optical fiber is used as a light path, and measurement light, reference light, reflected light, and the like are guided to each part.

The light source unit 102 includes a light source 110 and an optical system 112, and makes the light La enter the optical fiber FB1.
The light source 110 is a light emitting device that emits low-coherent light. For example, a supercontinuum that obtains broadband light by irradiating a nonlinear medium with SLD (Super Luminescent Diode), ASE (Amplified Spontaneous Emission), or ultrashort pulse laser light. Etc. can be used.
The optical system 112 is disposed on the optical path of the light emitted from the light source 110, collects the light emitted from the light source 110, and makes the light enter the optical fiber FB1.

  The interference light detection unit 104 includes a collimator lens 122 that collimates the interference light L4 emitted from the optical fiber FB4, a spectroscopic unit 124 that splits the interference light L4 having a plurality of wavelength bands for each wavelength band, and a spectroscopic unit 124. And a light detecting means 128 for detecting the interference light L4 collected by the lens 126, which are combined by the branching and combining unit 14. The interference light L4 between the reflected light L3 and the reference light L2 is detected as an interference signal.

The spectroscopic means 124 is composed of, for example, a diffraction grating element, etc., and splits the incident interference light L4 and emits it toward the light detection means 128.
The light detection means 128 is composed of, for example, an element such as a CCD in which light sensors are arranged one-dimensionally or two-dimensionally, and each light sensor separates the interference light L4 separated as described above for each wavelength band. Detect as an interference signal.
The interference light detection unit 104 sends the detected interference signal to the processing unit 22.
The contact area detecting unit 86 and the tomographic image generating unit 88 of the processing unit 22 can calculate the relationship between the frequency component and the intensity for each line by applying FFT to each of the separated interference light L4. By further processing the relationship between the component and the intensity to acquire the relationship between the depth direction and the intensity, the peak position in the depth direction and the intensity distribution can be obtained as in the optical tomographic imaging apparatus 10.
The contact area detection means 86 detects the contact area between the outer circumference of the probe and the measurement object from the detected peak position in the depth direction and the intensity distribution, and the tomographic image generation means 88 acquires a tomographic image.

  As described above, although the acquisition method of the interference signal is different, the optical tomographic imaging apparatus 100 is also the same as the optical tomographic imaging apparatus 10 by detecting the contact area between the outer periphery of the probe and the measurement target by the contact area detection unit. The effect of can be obtained.

Next, FIG. 11 is a block diagram schematically showing a schematic configuration of still another embodiment of the optical tomographic imaging apparatus.
Here, the optical tomographic imaging apparatus 200 shown in FIG. 11 obtains a tomographic image of a measurement target by TD-OCT (time domain-OCT) measurement, and detects a contact area with the measurement target. Since the other configuration is the same as that of the optical tomographic imaging apparatus 10, the same components are denoted by the same reference numerals, and detailed description thereof will be omitted. Will be described.

  The optical tomographic imaging apparatus 10 divides light emitted from the light source unit 202 that emits light and the light source unit 12 into measurement light and reference light, and combines reflected light and reference light to generate interference light. The branching / multiplexing unit 14, the optical probe 16 that guides the measurement light and irradiates the measurement target, and further reflects the reflected light from the measurement target, and adjusts the optical path length of the reference light to periodically change the optical path length. Acquired by the adjustment unit 204, the interference light detection unit 206 that detects the interference light generated by the branching and multiplexing unit 14, the processing unit 22 that processes the detection result detected by the interference light detection unit 20, and the processing unit 22 And a display unit 24 for displaying the obtained tomographic image. Furthermore, the optical tomographic imaging apparatus 10 includes a rotation drive unit 26 that rotates a measurement unit of the optical probe, an optical fiber coupler 28 that splits light emitted from the light source unit 12, and a detection unit 30a that detects reference light. And a detection unit 30b that detects reflected light, and an operation control unit 32 that inputs various conditions to the processing unit 22 and the display unit 24, changes settings, and the like. Further, an optical fiber is used as a light path, and measurement light, reference light, reflected light, and the like are guided to each part.

The light source unit 202 includes a light source 208 and an optical system 112, and makes the light La enter the optical fiber FB1.
The light source 208 is a light emitting device that emits laser light La having a predetermined wavelength.
The optical system 112 is disposed on the optical path of the light emitted from the light source 208, collects the laser light La emitted from the light source 110, and enters the optical fiber FB1.

The optical path length adjustment unit 204 is a collimator lens 210 that collimates the reference light L2 emitted from the optical fiber FB3, and a mirror 212 that is disposed on the optical path of the collimator lens 210 and is movable in the direction of arrow A in the figure. And a base 214 that supports the mirror 212 and a mirror moving mechanism 216 that moves the base 214 in the direction of arrow A in the figure.
The optical path length adjustment unit 204 expands and contracts the distance between the mirror 212 and the collimator lens 21 by moving the mirror 212 by the mirror moving mechanism 216, and changes the optical path length of the reference light L2. The optical path length adjustment unit 204 changes the measurement position in the measurement target S in the depth direction by moving the mirror 212 and changing the optical path length of the reference light L2.
The phase modulator 207 is arranged in the optical path of the reference light L2 (optical fiber FB3), and gives a slight frequency shift to the reference light L2.
The reference light L <b> 2 whose optical path length has been changed and frequency shifted by the optical path length adjustment unit 204 is guided to the branching / combining unit 14.
Further, as described above, the branching / multiplexing unit 14 combines the reference light L2 and the reflected light L3 to generate the interference light L4.

Next, the interference light detection unit 206 detects the light intensity of the interference light L4 that has propagated from the branching and combining unit 14 through the optical fiber FB2, for example, by heterodyne detection. Specifically, when the sum of the total optical path length of the measurement light L1 and the total optical path length of the reflected light L3 is equal to the total optical path length of the reference light L2, it is strong and weak at the difference frequency between the reference light L2 and the reflected light L3. A beat signal that repeats is generated. In this embodiment, this beat signal becomes an interference signal.
Therefore, the interference light detection unit 206 detects the beat signal, that is, the interference signal for each measurement position from the interference light L4 whose optical path length is changed by the optical path length adjustment unit 204 and changes in the measurement position (depth) of the measurement target S. Detect the signal. Here, this measurement position is determined by the optical path length of the reference light. Therefore, the measurement position can be calculated from the position of the mirror. The optical path length adjustment unit 204 includes a calculation unit that calculates a measurement position from the mirror position, and outputs the calculated measurement position to the interference light detection unit 204 and the processing unit 22.

The contact area detection unit 86 and the tomographic image generation unit 88 of the processing unit 22 calculate the relationship between the measurement position (that is, the depth direction) and the intensity by processing the beat signal for each measurement position. By acquiring the relationship between the calculated depth direction and intensity, the peak position in the depth direction and the intensity distribution can be obtained in the same manner as in the optical tomographic imaging apparatus 10.
The contact area detection means 86 detects the contact area between the outer circumference of the probe and the measurement object from the detected peak position in the depth direction and the intensity distribution, and the tomographic image generation means 88 acquires a tomographic image.

  As described above, although the acquisition method of the interference signal is different, the optical tomographic imaging apparatus 200 is also similar to the optical tomographic imaging apparatus 10 by detecting the contact area between the outer periphery of the probe and the measurement target by the contact area detection unit. The effect of can be obtained.

  As described above, the optical tomographic imaging apparatus, the contact area detection method, and the image processing method using the same according to the present invention have been described in detail. However, the present invention is not limited to the above embodiment, and the gist of the present invention. Various modifications and changes may be made without departing from.

  For example, in the above embodiment, in the case of SS-OCT measurement and SD-OCT measurement, FFT (Fast Fourier Transform) is used. However, the present invention is not limited to this, and various frequency analysis methods capable of calculating the relationship between frequency and intensity are used. Can be used.

It is a block diagram which shows schematic structure of the optical tomographic imaging apparatus of one Embodiment of the optical tomographic imaging apparatus of this invention using the contact region detection method and image processing method of this invention. It is a fragmentary sectional view which expands and shows the front-end | tip part of the optical probe of the optical tomographic imaging apparatus shown in FIG. It is a block diagram which shows schematic structure of the process part of the optical tomographic imaging apparatus shown in FIG. It is explanatory drawing for demonstrating the positional information on the measurement position of an optical probe. It is a graph which shows a typical example of the calculation result acquired by performing FFT on an interference signal. (A) And (B) is explanatory drawing for demonstrating the detection method of a contact region. It is a flowchart which shows the detection method of the position of a probe outer periphery. It is a flowchart which shows the detection method of a contact area. It is a flowchart which shows the image processing method which calculates a tomographic image based on the detected contact area. It is a block diagram which shows schematic structure of the optical tomographic imaging apparatus of other embodiment of the optical tomographic imaging apparatus of this invention. It is a block diagram which shows schematic structure of the optical tomographic imaging apparatus of other embodiment of the optical tomographic imaging apparatus of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10, 100, 200 Optical tomographic imaging apparatus 12 Light source unit 14 Branching / multiplexing part 16 Optical probe 18 Optical path length adjustment part 20 Interference light detection part 22 Processing part 24 Display part 26 Rotation drive part 28 Optical fiber coupler 30a, 30b Detection part 32 Operation unit 40 Semiconductor optical amplifier 42 Optical splitter 44 Collimator lens 46 Diffraction grating element 48 Optical system 50 Rotating polygon mirror (polygon mirror)
52 Probe outer cylinder 54 Cap 56 Optical fiber 58 Spring 60 Fixing member 62 Optical lens 64 First optical lens 66 Second optical lens 68 Reflective mirror 70 Base 72 Mirror drive mechanism 80 Interference signal acquisition means 82 A / D conversion means 84 Contact State detection means 86 Tomographic information generation means 88 Image correction means S Measurement object

Claims (9)

A light source;
A branching unit for branching light emitted from the light source into measurement light and reference light;
An optical fiber that transmits the measurement light, a measurement unit that is disposed at the tip of the optical fiber, irradiates the measurement object with light, covers the outer periphery of the optical fiber and the measurement unit, and covers the outer periphery of the measurement unit. The region where light is emitted from the optical probe including an outer cylinder formed of a transparent material,
A drive unit that rotates the measuring unit and the optical fiber and scans in a circumferential direction of an outer cylinder of the optical probe;
A combining unit that generates interference light by combining the reflected light detected by the measurement unit and the reference light;
An interference light detection unit that detects the interference light for each line as an interference signal for a plurality of lines that are measurement positions set at predetermined angles in the circumferential direction of the outer cylinder ,
A distance between the optical probe and the measurement target is calculated from the detected interference signal , and a region where the calculated distance between the optical probe and the measurement target is equal to or less than a certain value is detected and detected. A contact detection unit for detecting a contact area from the result,
It possesses a tomographic image acquisition unit that acquires a tomographic image from the previous SL interference signal lines of a predetermined line,
While the drive unit rotates the measurement unit and the optical fiber once, after the contact detection unit detects the contact region from the interference signal of each line detected by the interference light detection unit,
Based on the information of the contact area detected by the contact detection unit, the drive unit reciprocates only the contact area of the measurement unit and the optical fiber, and the measurement unit becomes a measurement object only in the contact area. The reflected light is obtained by irradiating the light, and the combining unit generates the interference light by combining the reflected light and the reference light, and the interference light detecting unit detects each of the interference light from the interference light only in the contact area. Detect line interference signals,
The tomographic image acquisition unit detects line tom in each line in the contact region from the interference signal detected by the interference light detection unit while the drive unit reciprocates the measurement unit and the optical fiber in the contact region. An optical tomographic imaging apparatus characterized by acquiring an image. A light source;
A branching unit for branching light emitted from the light source into measurement light and reference light;
An optical fiber that transmits the measurement light, a measurement unit that is disposed at the tip of the optical fiber, irradiates the measurement object with light, covers the outer periphery of the optical fiber and the measurement unit, and covers the outer periphery of the measurement unit. The region where light is emitted from the optical probe including an outer cylinder formed of a transparent material,
A drive unit that rotates the measuring unit and the optical fiber and scans in a circumferential direction of an outer cylinder of the optical probe;
A combining unit that generates interference light by combining the reflected light detected by the measurement unit and the reference light;
An interference light detection unit that detects the interference light for each line as an interference signal for a plurality of lines that are measurement positions set at predetermined angles in the circumferential direction of the outer cylinder ,
A distance between the optical probe and the measurement target is calculated from the detected interference signal , and a region where the calculated distance between the optical probe and the measurement target is equal to or less than a certain value is detected and detected. A contact detection unit for detecting a contact area from the result,
It possesses a tomographic image acquisition unit that acquires a tomographic image from the previous SL interference signal lines of a predetermined line,
While the drive unit rotates the measurement unit and the optical fiber once, after the contact detection unit detects the contact region from the interference signal of each line detected by the interference light detection unit,
The drive unit rotates the measurement unit and the optical fiber, the measurement unit irradiates light to the measurement object to acquire the reflected light, and a multiplexing unit combines the reflected light and the reference light. Interference light is generated, the interference light detection unit detects the interference signal of each line from the interference light,
The tomographic image acquisition unit acquires a tomographic image of a line from the interference signal for each predetermined line in a region other than the contact region based on the information on the contact region detected by the contact detection unit, and the contact In the area, the tomographic image of the line in the contact area is obtained in all the lines by acquiring the tomographic image of the line from the interference signal in comparison with the case of acquiring the tomographic image of the line in the area other than the contact area. An optical tomographic imaging apparatus characterized in that the interval between lines in the case of acquiring the image is reduced. A light source;
A branching unit for branching light emitted from the light source into measurement light and reference light;
An optical fiber that transmits the measurement light, a measurement unit that is disposed at the tip of the optical fiber, irradiates the measurement object with light, covers the outer periphery of the optical fiber and the measurement unit, and covers the outer periphery of the measurement unit. The region where light is emitted from the optical probe including an outer cylinder formed of a transparent material,
A drive unit that rotates the measuring unit and the optical fiber and scans in a circumferential direction of an outer cylinder of the optical probe;
A combining unit that generates interference light by combining the reflected light detected by the measurement unit and the reference light;
An interference light detection unit that detects the interference light for each line as an interference signal for a plurality of lines that are measurement positions set at predetermined angles in the circumferential direction of the outer cylinder ,
A distance between the optical probe and the measurement target is calculated from the detected interference signal , and a region where the calculated distance between the optical probe and the measurement target is equal to or less than a certain value is detected and detected. A contact detection unit for detecting a contact area from the result,
It possesses a tomographic image acquisition unit that acquires a tomographic image from the previous SL interference signal lines of a predetermined line,
While the drive unit rotates the measurement unit and the optical fiber once, after the contact detection unit detects the contact region from the interference signal of each line detected by the interference light detection unit,
Based on the information on the contact area detected by the contact detection unit, the driving unit rotates a rotation speed when rotating the measurement unit and the optical fiber in an area other than the contact area in the contact area. When the rotation speed is higher than the rotation speed, the measurement unit irradiates light to the measurement object at different line intervals in the contact region and the region other than the contact region, and obtains the reflected light. The reflected light and the reference light are combined to generate interference light, and the interference light detection unit detects the interference signal of each line,
For each line detected by the interference light detection unit, the tomographic image acquisition unit causes the drive unit to rotate the measurement unit and the optical fiber at different rotation speeds in the contact region and the region other than the contact region. In the case of acquiring a tomographic image of a line in the contact area by acquiring a tomographic image of a line for each line from the interference signal, compared to acquiring a tomographic image of a line in an area other than the contact area. An optical tomographic imaging apparatus characterized by reducing a line interval . The contact detection unit, every time the measuring unit and the optical fiber by the driving unit is a predetermined number of times the rotation, optical tomographic imaging apparatus according to claim 1 for detecting the contact state. Further, the optical tomographic imaging apparatus according to any one of claims 1 to 4 having a display unit for displaying the tomographic image acquired by the tomographic image obtaining unit. Further, the optical tomographic imaging apparatus according to the contact area, in claim 5 for displaying superimposed on the tomographic image. Further, the optical tomographic imaging apparatus according to any one of claims 1 to 6 having an operation section for changing the contact area detected by the contact detection unit. Furthermore, an optical path length adjusting unit that is provided on the optical path of the reference light and adjusts the optical path length of the reference light,
Wherein by changing the optical path length of the reference light by the optical path length adjusting means, the optical tomographic imaging apparatus according to any one of claims 1 to 7 for generating an interference light for each position in the depth direction of the measurement object. The interference light detection unit detects an interference signal for each spectral component of light,
The contact detection unit performs frequency analysis on the interference signal, calculates a distance between the optical probe and the measurement target from an analysis result,
The tomographic image acquisition unit, the interference signal frequency analysis, optical tomographic imaging apparatus according to any one of claims 1 to 8 for obtaining a tomographic image from the analysis result.

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