JP5002109B2 - セル接着の防止剤としての新規なグアニジノ誘導体 - Google Patents
セル接着の防止剤としての新規なグアニジノ誘導体 Download PDFInfo
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- JP5002109B2 JP5002109B2 JP2002515897A JP2002515897A JP5002109B2 JP 5002109 B2 JP5002109 B2 JP 5002109B2 JP 2002515897 A JP2002515897 A JP 2002515897A JP 2002515897 A JP2002515897 A JP 2002515897A JP 5002109 B2 JP5002109 B2 JP 5002109B2
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- Prior art keywords
- alkyl
- aryl
- heteroaryl
- formula
- cycloalkyl
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- UQHDOKOGAIQWOU-VXKWHMMOSA-N tert-butyl (2r)-2-(benzenesulfonamido)-3-[[(2r)-2-(benzenesulfonamido)-3-[(2-methylpropan-2-yl)oxy]-3-oxopropyl]disulfanyl]propanoate Chemical compound N([C@@H](CSSC[C@@H](C(=O)OC(C)(C)C)NS(=O)(=O)C=1C=CC=CC=1)C(=O)OC(C)(C)C)S(=O)(=O)C1=CC=CC=C1 UQHDOKOGAIQWOU-VXKWHMMOSA-N 0.000 description 1
- FYNHCHDBJVQWOM-VXKWHMMOSA-N tert-butyl (2r)-2-amino-3-[[(2r)-2-[bis(benzenesulfonyl)amino]-3-[(2-methylpropan-2-yl)oxy]-3-oxopropyl]disulfanyl]propanoate Chemical compound C=1C=CC=CC=1S(=O)(=O)N([C@@H](CSSC[C@H](N)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)S(=O)(=O)C1=CC=CC=C1 FYNHCHDBJVQWOM-VXKWHMMOSA-N 0.000 description 1
- KAKUPRSTPGDOGM-NSOVKSMOSA-N tert-butyl (2r)-3-[[(2r)-3-[(2-methylpropan-2-yl)oxy]-2-(naphthalen-1-ylsulfonylamino)-3-oxopropyl]disulfanyl]-2-(naphthalen-1-ylsulfonylamino)propanoate Chemical compound C1=CC=C2C(S(=O)(=O)N[C@@H](CSSC[C@H](NS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)=CC=CC2=C1 KAKUPRSTPGDOGM-NSOVKSMOSA-N 0.000 description 1
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- PCFIPYFVXDCWBW-UHFFFAOYSA-N tricyclo[3.3.1.03,7]nonane Chemical compound C1C(C2)C3CC2CC1C3 PCFIPYFVXDCWBW-UHFFFAOYSA-N 0.000 description 1
- 125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00116385.6 | 2000-07-28 | ||
| EP00116385A EP1176145A1 (en) | 2000-07-28 | 2000-07-28 | Novel guanidino derivatives as inhibitors of cell adhesion |
| PCT/EP2001/008485 WO2002010168A1 (en) | 2000-07-28 | 2001-07-23 | Novel guanidino derivatives as inhibitors of cell adhesion |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004505084A JP2004505084A (ja) | 2004-02-19 |
| JP2004505084A5 JP2004505084A5 (enExample) | 2008-07-03 |
| JP5002109B2 true JP5002109B2 (ja) | 2012-08-15 |
Family
ID=8169381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002515897A Expired - Lifetime JP5002109B2 (ja) | 2000-07-28 | 2001-07-23 | セル接着の防止剤としての新規なグアニジノ誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7259159B2 (enExample) |
| EP (2) | EP1176145A1 (enExample) |
| JP (1) | JP5002109B2 (enExample) |
| AT (1) | ATE432934T1 (enExample) |
| AU (1) | AU2001278503A1 (enExample) |
| DE (1) | DE60138893D1 (enExample) |
| WO (1) | WO2002010168A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2870541B1 (fr) * | 2004-05-18 | 2006-07-14 | Proskelia Sas | Derives de pyrimidines antigonistes du recepteur de la vitronectine |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19653646A1 (de) * | 1996-12-20 | 1998-06-25 | Hoechst Ag | Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung |
| EP0933367A1 (en) * | 1997-12-19 | 1999-08-04 | Hoechst Marion Roussel Deutschland GmbH | Novel acylguanidine derivates as inhibitors of bone resorption and as vitronectin receptor antagonists |
| FR2786184B1 (fr) * | 1998-11-24 | 2002-09-20 | Hoechst Marion Roussel Inc | Nouveaux derives du benzofurane, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
-
2000
- 2000-07-28 EP EP00116385A patent/EP1176145A1/en not_active Withdrawn
-
2001
- 2001-07-23 WO PCT/EP2001/008485 patent/WO2002010168A1/en not_active Ceased
- 2001-07-23 AU AU2001278503A patent/AU2001278503A1/en not_active Abandoned
- 2001-07-23 JP JP2002515897A patent/JP5002109B2/ja not_active Expired - Lifetime
- 2001-07-23 US US10/343,173 patent/US7259159B2/en not_active Expired - Lifetime
- 2001-07-23 AT AT01956555T patent/ATE432934T1/de not_active IP Right Cessation
- 2001-07-23 EP EP01956555A patent/EP1313737B1/en not_active Expired - Lifetime
- 2001-07-23 DE DE60138893T patent/DE60138893D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE432934T1 (de) | 2009-06-15 |
| AU2001278503A1 (en) | 2002-02-13 |
| JP2004505084A (ja) | 2004-02-19 |
| DE60138893D1 (enExample) | 2009-07-16 |
| WO2002010168A1 (en) | 2002-02-07 |
| EP1313737A1 (en) | 2003-05-28 |
| US20030203896A1 (en) | 2003-10-30 |
| EP1313737B1 (en) | 2009-06-03 |
| EP1176145A1 (en) | 2002-01-30 |
| US7259159B2 (en) | 2007-08-21 |
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