JP4910380B2 - Tooth bleaching material and tooth bleaching method - Google Patents

Description

  The present invention relates to a bleaching method for bleaching and removing pigments (coloring, discoloration) deposited on teeth. More specifically, bleaching of a discolored tooth characterized in that a bleaching material having a specific composition having photocatalytic activity is attached to the surface of the discolored tooth, and the tooth is bleached based on a photocatalytic action caused by irradiating the part with light Material and bleaching method.

  In recent years, in dental practice, there has been a strong demand for improving aesthetics such as tooth shape, arrangement, and harmony, and in particular, there are cases where young women seek dental care to whiten teeth as an important cosmetic element. is increasing. In general, the causes of tooth discoloration or pigmentation (pigmentation, stain) are the deposition of colored substances (tobacco, tea astringency, etc.), pigment-producing bacteria, discoloration of restorations (mainly composite resins), metal salts (mainly So-called extrinsic substances such as amalgam, silver nitrate, silver ammonia) and so-called intrinsic substances due to aging, chemical substances and drugs (fluorine, tetracycline, etc.), metabolic abnormalities, genetic diseases, tooth injury, etc. ).

  As a method for improving the aesthetics of discolored teeth, several methods have been proposed in the past. Among them, the bleaching method has some problems such as a slight backlash. It can be said that this is an excellent treatment method with high preservation of tooth quality. This bleaching method is basically a method of removing a colored substance by a chemical reaction. Conventionally, the bleaching method for vital teeth and the non-vital bleaching method are mainly used. A bleaching material comprising various chemical agents and a bleaching method using the same have been reported.

  By the way, with respect to the bleaching material and bleaching method used for tooth bleaching, (a) the bleaching effect is remarkable, (b) the drug used is not toxic, (c) the work is simple, (d Various conditions are required such as :) the physical properties of the tooth are not deteriorated, (e) effective for both vital teeth and inactivated teeth, and (f) the bleaching effect appears in a short period of time. However, the bleaching material and the bleaching method that have been used in the past are based on the fact that 30 to 35% by weight of hydrogen peroxide water having strong tissue corrosivity is used as a main agent, and bleaching is performed by its oxidizing action. There were problems with simplicity and safety.

  In view of the current state of the bleaching method as described above, titanium oxide having a photocatalytic action as a new bleaching method and bleaching method which is excellent in safety and simplicity and has a remarkable effect on both myelinated and nonmedullary teeth in a short period of time. It has been reported that a bleaching material using a combination of a low-concentration hydrogen peroxide solution is effective (see Patent Document 1).

  In tooth bleaching material consisting of a combination of these photocatalytic titanium oxide and a compound that generates hydrogen peroxide in aqueous solution, inorganic clay minerals such as saponite and hectorite and inorganic thickeners such as silica gel or sodium polyacrylate, Organic thickeners such as methylcellulose and carboxymethylcellulose have been used (see Patent Documents 2 and 3). When organic thickeners are used among these thickeners, the decomposition reaction of organic thickeners proceeds by the action of titanium oxide, which has a photocatalytic action, and a compound that generates hydrogen peroxide in an aqueous solution. And large viscosity reduction may occur. For this reason, inorganic thickeners are preferred and used, more preferably inorganic clay minerals.

  On the other hand, in the conventional tooth bleaching, since it has been the mainstream to perform the bleaching process for each tooth, a tooth bleaching material having a fluid viscosity that allows easy application and wiping of the bleaching material has been preferred and used. Recently, however, tooth bleaching methods such as a method of irradiating and bleaching a large number of teeth such as 6 teeth and 8 teeth at once, a method using a light irradiator with stronger light intensity, etc. have been proposed, and high adhesion to the tooth surface It has come to be required to maintain and maintain.

In order to give high adhesion and retention to the tooth surface, there is a method to increase the viscosity by increasing the amount of thickener added, but in the case of inorganic clay minerals, the bleaching effect decreases due to the decrease in light transmittance In addition, problems such as poor adhesion to the tooth surface occur. There has been a demand for a bleaching material and a bleaching method that have excellent adhesion to and retention on the tooth surface and a high bleaching effect without increasing the amount of inorganic clay mineral added.
Japanese Patent No. 3030380 JP 2002-220330 A JP 2002-284656 A

  An object of the present invention is a tooth bleaching material composed of a combination of titanium oxide having a photocatalytic action, a compound that generates hydrogen peroxide in an aqueous solution, and an inorganic clay mineral. It is providing the tooth bleaching material and the bleaching method which improved.

  As a result of intensive research on the above-mentioned tooth bleaching material, the present inventors have developed a tooth comprising a combination of a compound containing titanium oxide that generates a photocatalytic action by light irradiation, a compound that generates hydrogen peroxide in an aqueous solution, and an inorganic clay mineral. By adding a slight organic thickener to the bleaching material, a synergistic effect of the inorganic clay mineral and the organic thickener can be obtained, resulting in an appropriate viscosity, improved adhesion to the tooth surface, and improved retention. It has been found that the tooth bleaching material having excellent operability can be obtained, and that the operability at the time of preparation can be improved by mixing an organic thickener later.

  That is, the present invention relates to a tooth bleaching material characterized by containing titanium oxide that generates a photocatalytic action by light irradiation, a compound that generates hydrogen peroxide in an aqueous solution, an inorganic clay mineral, and an organic thickener, and the tooth stray The present invention relates to a tooth bleaching method characterized by performing light irradiation by bringing a material into contact with a tooth surface.

  According to the tooth bleaching material and the bleaching method of the present invention, adhesion to the tooth surface is improved and application to a large number of teeth such as 6 teeth and 8 teeth is facilitated. Further, when a high-intensity light irradiator is used after application However, it retains well on the teeth, does not drip, and improves operability during preparation.

  Hereinafter, the present invention will be described in more detail. As the titanium oxide used in the present invention, any titanium oxide capable of producing a photocatalytic action can be used regardless of its form and properties. The titanium oxide is preferably a crystalline compound of any one of anatase type, rutile type and brookite type, and particularly a rutile type compound. Moreover, what improved affinity with the tooth surface can also be used by coating the surface of the compound containing titanium oxide with calcium phosphate. Furthermore, titanium oxide is supported by a metal such as platinum to improve the photocatalytic activity, or titanium oxide is responsive to light in the visible light region by plasma treatment, N-containing material or S-containing material. Those having a photocatalytic action can also be used.

  The titanium oxide may be in a powder state or a sol state dispersed in a medium such as water. The particle diameter of titanium oxide is preferably 1 to 500 nm, more preferably 5 to 200 nm. The effect is sufficiently obtained even when the amount of titanium oxide is small, specifically 0.001 to 10% by weight, preferably 0.01 to 1% by weight. If the blending amount is too small, it may take a long time to obtain a favorable result depending on the degree of discoloration of the tooth, and if it is too large, the light transmission property of titanium oxide itself is not good and the bleaching effect is lowered. Sometimes.

  The compound that generates hydrogen peroxide in the aqueous solution used in the present invention may be any compound that can generate hydrogen peroxide when made into an aqueous solution, such as hydrogen peroxide, perborate, percarbonate, superphosphorus. Acid salts, persulfates, calcium peroxide, magnesium peroxide, urea peroxide and the like can be mentioned, and hydrogen peroxide is preferred.

  In the tooth bleaching material of the present invention, the compound that generates hydrogen peroxide can obtain a remarkable bleaching effect at a sufficiently low concentration as compared with conventionally used bleaching materials. That is, the content of the compound that generates hydrogen peroxide in the aqueous solution is 35% by weight or less, preferably 1 to 10% by weight. Even if the content is higher than this range, there is no significant difference in the bleaching effect, and it is not advantageous from the viewpoint of safety.

  Examples of the inorganic clay mineral used in the present invention include dicalite, nacrite, kaolinite, anoxite, halloysite, metahalosite, chrysotile, lizardite, serpentine, antigolite, beidellite, montmorillonite, soconite, stevensite, nontronite. , Saponite, hectorite, vermiculite, smectite, sepiolite, nectite, illite, sericite, kailite-montmorillonite, rholite-montmorillonite, chlorite-vermiculite, illite-montmorillonite, halloysite-montmorillonite, kaolinite-montmorillonite, etc. It is done.

  Among the above inorganic clay minerals, layered structure type clay minerals such as montmorillonite, sauconite, smectite, stevensite, beidellite, nontronite, saponite, hectorite, vermiculite and nectite are more preferably used in the present invention. This is because the layered structure type inorganic clay mineral has the property of being easily swollen by incorporating water molecules between the unit layers in the structure. These inorganic clay minerals may be natural products or synthetic products. Synthetic products include synthetic sodium magnesium silicate lithium (Laponite) and the like. A mixture of two or more of these can also be used. In addition, the compounding quantity of these inorganic clay minerals becomes like this. Preferably it is 0.1 to 10 weight%, More preferably, it is 0.5 to 5 weight%.

  Examples of the organic thickener used in the present invention include starch, sodium starch glycolate, sodium starch phosphate ester, galactomannan, nitrocellulose, methylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose. Pectic acid, pectinic acid, sodium fibrinose, sodium alginate, agar, carrageenan, proteoglycan, glycoprotein, gelatin, actin, tubulin, hemoglobin S, insulin, fibrin, ovalbumin, serum albumin, myosin, collagen, poly Peptides, casein, polyvinyl alcohol, polyethylene glycol, polyethylene Oxides, polyacrylamides, carboxyvinyl polymers, polyvinyl pyrrolidone, methyl vinyl ether / maleic anhydride copolymer and the like.

  Of the above organic thickeners, sodium polyacrylate, sodium alginate, methylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, and carboxyvinyl polymer are more preferably used in the present invention. These may be natural products or synthetic products, and a mixture of two or more of these may be used. In addition, the addition amount of these organic thickeners becomes like this. Preferably it is 0.001 to 10 weight%, More preferably, it is 0.01 to 5 weight%.

  The viscosity of the tooth bleaching material is preferably 0.001 to 100 Pa · s, more preferably 0.02 to 50 Pa · s, and the types and additions of inorganic clay minerals and organic thickeners that give optimum viscosity. An amount is chosen. When the viscosity is within this range, the bleaching material has good adhesion to the tooth surface, can be easily applied to the tooth surface, and is applied to the tooth surface having an angle of 45 degrees with respect to the horizontal plane. The bleaching material will not sag.

  The form of adding the organic thickener in the present invention may be any form such as powder, solution or suspension. It may be added by a method with good workability. Usability at the time of preparation by adding an organic thickener to a tooth bleaching material consisting of a combination of a compound containing titanium oxide that generates photocatalysis by light irradiation, a compound that generates hydrogen peroxide in an aqueous solution, and an inorganic clay mineral Will be improved.

  The present invention is also applicable to tooth bleaching materials containing phosphoric acid and condensed phosphate used as stabilizers and bleach accelerators. As phosphoric acid, orthophosphoric acid is preferable. Examples of the condensed phosphate include potassium phosphate such as pyrophosphoric acid and tripolyphosphoric acid which are condensed phosphoric acid, sodium salt, etc., preferably tetrasodium pyrophosphate.

  In addition to the aforementioned components, the tooth bleaching material according to the present invention may contain a fragrance, a dye, a sensitizer, a solvent and the like.

  The tooth bleaching material of the present invention is used by applying the treatment directly on the tooth surface and irradiating light one or more times, preferably a plurality of times. The light to be irradiated is preferably light having a wavelength that can be absorbed by titanium oxide and cause photocatalytic action, and has a wavelength that has little adverse effect on the human body. As such a wavelength, light including a wavelength of 300 nm or more, more preferably light including a wavelength of 380 or more is used. Examples of the light source used in the present invention include exothermic lamps, fluorescent lamps, halogen lamps, black lights, metal halide lamps, xenon lamps, mercury lamps, UV lamps, LEDs (light emitting diodes), and semiconductor lasers. Unnecessary wavelengths of the light from these light sources may be cut through an appropriate filter.

  The frequency | count of application | coating of the tooth bleaching material of this invention and light irradiation can be suitably adjusted according to the grade of the discoloration degree of a tooth. The tooth bleaching material of the present invention is effective for bleaching both unmyelinated and myelinated teeth, and exhibits a remarkable effect in bleaching those teeth safely and simply.

  According to a preferred aspect of the present invention, a tooth bleaching material comprising a combination of a compound containing titanium oxide that generates a photocatalytic action by light irradiation, a compound that generates hydrogen peroxide in an aqueous solution, and an inorganic viscosity mineral is moderately easy to handle. It can be a tooth bleaching material with a high viscosity, it can be a tooth bleaching material with improved adhesion and retention on the tooth surface and excellent operability, and when treating many teeth at once, it has high strength Bleaching treatment becomes easier when using a light irradiator.

EXAMPLES Hereinafter, although an Example demonstrates this invention concretely, this invention does not receive a restriction | limiting at all to a following example.
The adhesion and retention on the tooth surface were examined by (1) viscosity measurement, (2) evaluation of adhesion to the tooth surface, and (3) evaluation of retention on the tooth surface.

<Viscosity measurement>
The viscosity of the tooth bleaching material at 25 ° C. was measured by a single cylindrical rotational viscometer (Shibaura System Co., Ltd. Bismetron viscometer).

<Evaluation of adhesion to tooth surface>
1) Each tooth bleaching material of Examples and Comparative Examples was applied three times to the extracted tooth (maxillary anterior tooth) using a dental brush.
2) The weight applied to the extracted tooth when applied was observed and evaluated according to the following criteria.
○: The coating amount is 0.05 g or more. Δ: The coating amount is 0.01 to 0.05 g.
X: The coating amount is 0.01 g or less. The results are shown in Table 1.

<Evaluation of retention on tooth surface>
1) Each tooth bleaching material of Examples and Comparative Examples was placed on extracted teeth (maxillary anterior teeth).
2) The extracted tooth was inclined at 90 ° C. from the horizontal plane and held for 5 minutes, and the dripping property of the tooth bleaching material was evaluated according to the following criteria.
○: No dripping was observed for 5 minutes.
Δ: Liquid dripping was confirmed in 1 to 5 minutes.
X: Liquid dripping was confirmed up to 1 minute.
The results are summarized in Table 1.

Example 1
Tooth bleaching material was prepared by adding purified water to 0.06 g of titanium oxide, 10.00 g of 35 wt% hydrogen peroxide and 1.50 g of laponite (inorganic clay mineral) to a total amount of 99 g. To this, 1.00 g of sodium carboxymethylcellulose was added and stirred to prepare a tooth bleaching material.

Example 2
Tooth bleaching material was prepared by adding purified water to 0.06 g of titanium oxide, 10.00 g of 35 wt% hydrogen peroxide and 1.50 g of laponite (inorganic clay mineral) to a total amount of 99 g. To this was added 1.00 g of hydroxyethyl cellulose and stirred to prepare a tooth bleaching material.

Example 3
Tooth bleaching material was prepared by adding purified water to 0.06 g of titanium oxide, 10.00 g of 35 wt% hydrogen peroxide and 1.50 g of laponite (inorganic clay mineral) to a total amount of 99 g. To this was added 1.00 g of carboxyvinyl polymer and stirred to prepare a tooth bleaching material.

Example 4
Tooth bleaching material with a total amount of 99 g was prepared by adding purified water to 0.06 g of titanium oxide, 10.00 g of 35 wt% hydrogen peroxide, and 1.50 g of saponite (inorganic clay mineral). To this, 1.00 g of sodium carboxymethylcellulose was added and stirred to prepare a tooth bleaching material.

Example 5
Add purified water to 0.06 g of titanium dioxide, 10.00 g of 35 wt% hydrogen peroxide, 0.60 g of phosphoric acid, 2.00 g of pyrosodium pyrophosphate and 10 hydrate, 1.50 g of laponite (inorganic clay mineral) A tooth bleaching material having a weight of 99 g was prepared. To this, 1.00 g of sodium carboxymethylcellulose was added and stirred to prepare a tooth bleaching material.

Comparative Example 1
Tooth bleaching material was prepared by adding purified water to 0.06 g of titanium oxide, 10.00 g of 35 wt% hydrogen peroxide and 1.5 g of laponite (inorganic clay mineral) to make the total amount 100 g.

Comparative Example 2
Tooth bleaching material was prepared by adding purified water to 0.06 g of titanium oxide, 10.00 g of 35 wt% hydrogen peroxide and 10 g of laponite (inorganic clay mineral) to make the total amount 100 g.

Comparative Example 3
Tooth bleaching material was prepared by adding purified water to 0.06 g of titanium oxide, 10.00 g of 35 wt% hydrogen peroxide and 1.0 g of sodium carboxymethylcellulose to make the total amount 100 g.

Claims (6)

A tooth bleaching material comprising titanium oxide that generates a photocatalytic action when irradiated with light, a compound that generates hydrogen peroxide in an aqueous solution, a layered clay mineral, and an organic thickener.   The tooth bleaching material according to claim 1, further comprising phosphoric acid and / or condensed phosphate.   The tooth according to claim 1 or 2, wherein the organic thickener is at least one selected from the group consisting of sodium polyacrylate, sodium alginate, methylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, and carboxyvinyl polymer. Bleaching material. A tooth bleaching material containing a compound containing titanium oxide that generates photocatalysis by light irradiation, a compound that generates hydrogen peroxide in an aqueous solution, a layered clay mineral, and an organic thickener is brought into contact with the tooth surface for light irradiation. A tooth bleaching method characterized by performing. The tooth bleaching method according to claim 4, wherein the tooth bleaching material further contains phosphoric acid and / or condensed phosphate. Sodium organic thickener is polyacrylic acid, sodium alginate, methyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, according to claim 4 or 5 is at least one selected from the group consisting of carboxyvinyl polymers Bleaching method.