JP4893932B2 - Manufacturing method of aseptic filling package - Google Patents

Manufacturing method of aseptic filling package Download PDF

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JP4893932B2
JP4893932B2 JP2006192231A JP2006192231A JP4893932B2 JP 4893932 B2 JP4893932 B2 JP 4893932B2 JP 2006192231 A JP2006192231 A JP 2006192231A JP 2006192231 A JP2006192231 A JP 2006192231A JP 4893932 B2 JP4893932 B2 JP 4893932B2
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mold
container
parison
aseptic filling
manufacturing
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JP2008018968A (en
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力 岩崎
尚人 松田
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Toyo Seikan Kaisha Ltd
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Toyo Seikan Kaisha Ltd
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Description

本発明は、容器の製造、その容器への内容物の充填、密封を無菌的に行う無菌充填包装体の製造方法に関する。   The present invention relates to a method for producing an aseptic filling package that performs aseptic manufacture of a container, filling of the contents into the container, and sealing.

従来、1回で使い切る小容量の医薬、医薬部外品等の内容物を容器内に収納し、容器口部に内容物を注出する注射針等の注出具を取り付けた注出具付プラスチック容器が知られている。
そして、このようなプラスチック容器を製造する際に、衛生管理の観点から容器成形と同時に内容物を充填することも知られている。(例えば、特許文献1乃至4。)
さらに、本出願人にも、注出具の保護性、内容物の注出性及びタンパーエビデント性を改善した注出具を一体に収納した無菌充填包装体、及び内容物を充填するプラスチック本体の成形と内容物の無菌充填、容器本体と一体の保護ケースの成形、及び保護ケース内への注出具の収納を連続して行うことができる前記無菌充填包装体の製造方法及びその製造装置を提案した。(特許文献5。)
Conventionally, a plastic container with a dispensing tool in which contents such as small-volume medicines and quasi-drugs that can be used once are stored in a container, and a dispensing tool such as a syringe needle that dispenses the contents into the container mouth is attached. It has been known.
And when manufacturing such a plastic container, filling a content simultaneously with container shaping | molding from a viewpoint of hygiene management is also known. (For example, Patent Documents 1 to 4)
In addition, the applicant also formed an aseptic filling package integrally containing a pouring tool that improved the protection of the pouring tool, the pouring property of the contents, and the tamper evidence, and the molding of the plastic body filling the contents. And the aseptic filling of the contents, the formation of a protective case integral with the container body, and the storage of the pouring tool into the protective case, and the manufacturing method and manufacturing apparatus for the aseptic filling package have been proposed. . (Patent Document 5)

特開昭58−73537号公報JP 58-73537 A 特開平8−207126号公報JP-A-8-207126 特開2002−46725号公報JP 2002-46725 A 特表2006−500259号公報JP 2006-500509A PCT/JP2006/301872PCT / JP2006 / 301877

しかしながら、前記した従来の容器の製造、容器への内容物の充填、密封を無菌的に行う方法においては、プラスチック容器の成形と内容物の無菌充填を連続して行おうとすると、例えば、前記特許文献5においては、図2に例示すように、容器成形用金型12と保護ケース成形用金型13から成る金型11を、押出機17から押し出されるパリソンPの押出速度に同期して昇降させなければならない。   However, in the conventional method of manufacturing a container, filling the contents into the container, and sealing the container aseptically, if the molding of the plastic container and the aseptic filling of the contents are continuously performed, for example, the patent In Document 5, as illustrated in FIG. 2, the mold 11 including the container molding die 12 and the protective case molding die 13 is moved up and down in synchronization with the extrusion speed of the parison P extruded from the extruder 17. I have to let it.

図2に基づき従来の無菌充填包装体の製造方法の工程を説明する。
(1)金型11の容器成形用金型12の型締め。(第1型締め)
(2)ノズル15を容器成形用金型12に挿入する。
(3)無菌エアーにより容器本体Bをブロー成形する。
(4)ノズル15から内容物の充填を行う。
(5)ノズル15を容器成形用金型11から退避させる。
(6)ノズル15から、注射針、注出具等の機能部材Kを挿入する挿入ユニット16への切り替えを行う。
(7)挿入ユニット16によって注射針、注出具等の機能部材Kをケース成形用金型13に待機するパリソン内に挿入する。
(8)ケース成形用金型13の下方のヒートシール金型14の型締めを行い、容器本体Bの上部と機能部材Kの下部をヒートシールする。(第2型締め)
(9)注射針、注出具等の機能部材Kの挿入ユニット16の退避を行う。
(10)金型11のケース成形用金型13の型締め(第3型締め)を行う。
(11)ケース成形用金型13にサイドブロー(図示せず)を行い、ケースCをブロー成形する。
(12)金型11の型開きと無菌充填包装体の取り出しを行う。
(13)押出機7からパリソンを金型1に供給して待機する。
Based on FIG. 2, the process of the manufacturing method of the conventional aseptic filling package is demonstrated.
(1) Clamping the container forming mold 12 of the mold 11. (1st mold clamping)
(2) The nozzle 15 is inserted into the container molding die 12.
(3) The container body B is blow-molded with aseptic air.
(4) The contents are filled from the nozzle 15.
(5) The nozzle 15 is retracted from the container molding die 11.
(6) The nozzle 15 is switched to the insertion unit 16 for inserting the functional member K such as an injection needle and a dispensing tool.
(7) The functional unit K such as an injection needle and a dispensing tool is inserted into the parison on the case molding die 13 by the insertion unit 16.
(8) The heat sealing die 14 below the case molding die 13 is clamped, and the upper part of the container body B and the lower part of the functional member K are heat sealed. (Second mold clamping)
(9) The insertion unit 16 of the functional member K such as an injection needle or a dispensing tool is retracted.
(10) Clamping the case molding die 13 of the die 11 (third die clamping) is performed.
(11) Side blow (not shown) is performed on the case molding die 13 to blow-mold the case C.
(12) The mold 11 is opened and the aseptic filling package is taken out.
(13) Supply the parison from the extruder 7 to the mold 1 and wait.

従って、容器のブロー成形、内容物の充填、保護ケースの成形等における前記金型11、12の昇降の際の移動距離に応じて、次サイクルに利用できないパリソン(ムダ樹脂)Mが発生する。また、ムダ樹脂Mの自重によるパリソンPのドローダウンが発生し、前記金型11からプラスチック容器を取り出した後に、前記ドローダウンを発生したパリソンPを用いて再度連続的にブロー成形を行うため、ブロー成形性、生産性の低下を招く恐れがある。   Accordingly, a parison (waste resin) M that cannot be used in the next cycle is generated depending on the movement distance when the molds 11 and 12 are moved up and down in container blow molding, filling of contents, molding of a protective case and the like. In addition, since the drawdown of the parison P occurs due to the dead weight of the waste resin M, and the plastic container is taken out from the mold 11, continuous blow molding is performed again using the parison P that generated the drawdown. There is a risk of reducing blow moldability and productivity.

本発明では、前記課題を解決するため、次の1、2の構成を採用する。
1.押出機から押し出されるパリソンを金型に配置し、パリソン内に挿入したノズルから無菌エアーを吹き出して容器本体をブロー成形し、該ノズルから容器内に内容物を充填した後、該ノズルを退避させ、次いで、金型の上方と押出機の間に位置するパリソンの上下端部を閉口状態にカットしてムダ樹脂を排出することを特徴とする無菌充填包装体の製造方法
2.前記容器本体の上方のパリソンに機能部材を挿入し、該機能部材を収納するケースをブロー成形する1に記載の無菌充填包装体の製造方法。
In the present invention, the following configurations 1 and 2 are adopted to solve the above-described problems.
1. Place the parison extruded from the extruder in the mold, blow out aseptic air from the nozzle inserted into the parison, blow mold the container body, fill the container with the contents, and then retract the nozzle Subsequently, the upper and lower ends of the parison located between the upper side of the mold and the extruder are cut into a closed state, and the waste resin is discharged. 2. The method for producing an aseptic filling package according to 1, wherein a functional member is inserted into a parison above the container body, and a case for housing the functional member is blow-molded.

本発明によれば、無菌充填包装体の製造において、金型の上方と押出機の間に位置するパリソンの上下端部を閉口状態にカットしてムダ樹脂の除去が行われるため、ムダ樹脂の自重によるドローダウンが抑制され、前記ドローダウンの抑制によって無菌充填包装体の成形性、生産性が向上すると共に、容器内部、パリソン内部の外部環境による汚染等が防止される。   According to the present invention, in the manufacture of an aseptic filling package, since the waste resin is removed by cutting the upper and lower ends of the parison located between the upper part of the mold and the extruder into a closed state, the waste resin is removed. Drawdown due to its own weight is suppressed, and by suppressing the drawdown, the moldability and productivity of the aseptic filling package are improved, and contamination by the external environment inside the container and the parison is prevented.

本発明の無菌充填包装体の製造方法を図面に基づいて説明するが、以下具体例は本発明を限定するものではない。
図1は、本発明の無菌充填包装体の製造方法の一例を示す図で、次の工程(1)〜(14)により製造を行うことができる。
(1)金型1の容器成形用金型2の型締め。(第1型締め)
(2)ノズル5を容器成形用金型2に挿入する。
(3)無菌エアーにより容器本体Bをブロー成形する。
(4)ノズル5から内容物の充填を行う。
(5)ノズル5を容器成形用金型1から退避させる。
(6)ノズル5から、注射針、注出具等の機能部材Kを挿入する挿入ユニット6への切り替えを行う。
(7)挿入ユニット6によって注射針、注出具等の機能部材Kをケース成形用金型3に待機するパリソン内に挿入する。
(8)ケース成形用金型3の下方のヒートシール金型4の型締めを行い、容器本体Bの上部と機能部材Kの下部をヒートシールする。(第2型締め)
(9)注射針、注出具等の機能部材の挿入ユニット6の退避を行う。
(10)金型1のケース成形用金型3の型締め(第3型締め)と、押出機7の下方のパリソンカッター8によってパリソンPのムダ樹脂を、パリソン上下端を閉口状態にしてカットする。
(11)ムダ樹脂の除去を行う。
(12)ケース成形用金型3にサイドブロー(図示せず)を行い、ケースCをブロー成形する。
(13)金型1の型開きと無菌充填包装体の取り出しを行う。
(14)押出機7からパリソンを金型1に供給して待機する。
Although the manufacturing method of the aseptic filling package of this invention is demonstrated based on drawing, a specific example does not limit this invention below.
Drawing 1 is a figure showing an example of a manufacturing method of an aseptic filling package of the present invention, and can manufacture by the following processes (1)-(14).
(1) Clamping the mold 2 for forming the container of the mold 1. (1st mold clamping)
(2) Insert the nozzle 5 into the container molding die 2.
(3) The container body B is blow-molded with aseptic air.
(4) The contents are filled from the nozzle 5.
(5) The nozzle 5 is retracted from the container molding die 1.
(6) The nozzle 5 is switched to the insertion unit 6 for inserting a functional member K such as an injection needle or a dispensing tool.
(7) The functional unit K such as an injection needle and a dispensing tool is inserted into the parison on the case molding die 3 by the insertion unit 6.
(8) The heat sealing mold 4 below the case molding mold 3 is clamped, and the upper part of the container body B and the lower part of the functional member K are heat sealed. (Second mold clamping)
(9) The insertion unit 6 for functional members such as an injection needle and a dispensing tool is retracted.
(10) Clamping the mold 1 for case molding of the mold 1 (third mold clamping) and cutting the waste resin of the parison P by the parison cutter 8 below the extruder 7 with the upper and lower ends of the parison closed. To do.
(11) The waste resin is removed.
(12) Side blow (not shown) is performed on the case molding die 3, and the case C is blow molded.
(13) Open the mold 1 and remove the aseptic filling package.
(14) Supply the parison from the extruder 7 to the mold 1 and wait.

従って、本発明の無菌充填包装体の製造においては、前記工程(10)、(11)で、金型1の容器成形用金型2の上方と押出機7の間に位置するパリソンPの上下端部を、閉口状態にカットしてムダ樹脂Mの除去が行われるため、ムダ樹脂Mの自重によるドローダウンが抑制され、前記ドローダウンの抑制によって無菌充填包装体の成形性、生産性が向上すると共に、容器内部、パリソン内部の外部環境による汚染等が防止される。   Therefore, in the manufacture of the aseptic filling package according to the present invention, the upper and lower sides of the parison P located between the upper part of the container-forming mold 2 of the mold 1 and the extruder 7 in the steps (10) and (11). Since the waste resin M is removed by cutting the end portion into a closed state, the drawdown due to the dead weight of the waste resin M is suppressed, and the moldability and productivity of the aseptic filling package are improved by the suppression of the drawdown. In addition, contamination by the external environment inside the container and inside the parison is prevented.

本発明の無菌充填包装体の製造方法の工程を示す参考図である。It is a reference figure which shows the process of the manufacturing method of the aseptic filling package of this invention. 従来の無菌充填包装体の製造方法の工程を示す参考図である。It is a reference figure which shows the process of the manufacturing method of the conventional aseptic filling packaging body.

符号の説明Explanation of symbols

1 金型
2 容器成形用金型
3 ケース成形用金型
4 ヒートシール金型
5 ノズル
6 挿入ユニット
7 押出機
8 パリソンカッター
DESCRIPTION OF SYMBOLS 1 Mold 2 Container mold 3 Case mold 4 Heat seal mold 5 Nozzle 6 Insertion unit 7 Extruder 8 Parison cutter

Claims (2)

押出機から押し出されるパリソンを金型に配置し、パリソン内に挿入したノズルから無菌エアーを吹き出して容器本体をブロー成形し、該ノズルから容器内に内容物を充填した後、該ノズルを退避させ、次いで、金型の上方と押出機の間に位置するパリソンの上下端部を閉口状態にカットしてムダ樹脂を排出することを特徴とする無菌充填包装体の製造方法。 Place the parison extruded from the extruder in the mold, blow out sterile air from the nozzle inserted into the parison, blow mold the container body, fill the container with the contents, and then retract the nozzle Then, the manufacturing method of the aseptic filling package characterized by cutting the upper and lower ends of the parison located between the upper part of the mold and the extruder into a closed state and discharging the waste resin. 前記容器本体の上方のパリソンに機能部材を挿入し、該機能部材を収納するケースをブロー成形する請求項1に記載の無菌充填包装体の製造方法。
The manufacturing method of the aseptic filling package body of Claim 1 which inserts a functional member in the parison above the said container main body, and blow-molds the case which accommodates this functional member.
JP2006192231A 2006-07-12 2006-07-12 Manufacturing method of aseptic filling package Active JP4893932B2 (en)

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JP2008272826A (en) 2007-02-15 2008-11-13 Ihi Corp Stiffened plate and process for producing the same
KR200450052Y1 (en) * 2010-02-17 2010-09-01 정은테크 주식회사 Parison bonding / cutting device to form plastic ampoules
KR100979512B1 (en) * 2010-02-17 2010-09-02 정은테크 주식회사 Devicr for manufacture plastic ampoule and methode for manufacture there of
US11027862B2 (en) 2014-06-23 2021-06-08 Woodstock Sterile Solutions, Inc. Cold blow-fill-seal packaging system and process

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US4707966A (en) * 1981-08-26 1987-11-24 Automatic Liquid Packaging, Inc. Container with an encapsulated top insert and method and apparatus for making same
JP2530695B2 (en) * 1988-09-30 1996-09-04 三井石油化学工業株式会社 Method and device for manufacturing a fraction container in which the partition part is easily communicated by an external force
DE10245318A1 (en) * 2002-09-27 2004-04-08 Hansen, Bernd, Dipl.-Ing. Blow molding and/or vacuum forming process for manufacture of a fluid filled container involves molding the container, filling with fluid, insertion of a plug with cannula and molding tube end to form a cover

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