JP4873439B2 - Topical skin preparation - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a skin cleanser comprising a fatty soap, characterized in that it comprises surfactin and / or a salt thereof, ethylene glycol monostearate or ethylene glycol distearate, acyl isethionate and / or a salt thereof, and more particularly Relates to a skin cleanser that is more stable and usable than conventional ones.
[0002]
[Prior art]
In order to keep the skin beautiful, it is necessary to remove excess sebum, waste products, dirt, etc., and to clean the skin. In particular, sebum produces lipid peroxides by exposure to light, and may cause inflammation and the like on the skin, and it is very important to wash the skin.
[0003]
The most widely used skin cleanser is a solid soap, but a cream cleanser is generally used to clean the face. The main component of this creamy detergent is generally fatty acid soap. This fatty acid soap can obtain a creamy dosage form with high usability by combining those having 12 to 22 carbon atoms. In addition, for the purpose of improving detergency and reducing skin irritation, these fatty acid soaps include taurine-based active agents such as coconut oil fatty acid methyl taurine salt, alkyl sarcosinate-based active agents such as lauroyl sarcosine salt, In many cases, an anionic surfactant such as an acylamino acid type active agent such as N-coconut oil fatty acid-L-glutamate or an amphoteric surfactant such as a betaine type active agent such as lauryldimethylaminoacetic acid betaine is often added. . It is also common to add a polyhydric alcohol such as glycerin in order to reduce moisture retention and skin irritation.
[0004]
It is desirable to select a fatty acid soap from the viewpoint of detergency, but it is desirable to contain a large amount of laurate, myristate, etc. with a small number of carbon atoms. Absent. Moreover, there is a problem in the stability of the fatty acid salt in the high temperature part and changes over time due to the low melting point. Furthermore, laurate has a problem of skin irritation compared to other fatty acid salts. It is desirable to include stearates and behenates with a large number of carbons in order to improve the stability at high temperatures and changes over time, but if many of these are included, poor foaming and familiarity with water There is a problem in usability such as badness.
[0005]
As a means for solving such problems and obtaining a skin cleanser having both stability and usability, a blend of maltitol monofatty acid ester and diglycerin as described in Patent Document 1 or Patent Document 2 A compound containing a polyhydric alcohol having 3 or less carbon atoms and a polyhydric alcohol having 4 or more carbon atoms is known.
[0006]
[Patent Document 1]
JP 2001-39857 A [Patent Document 2]
Japanese Patent Laid-Open No. 2002-154946
[Problems to be solved by the invention]
Polyhydric alcohols greatly affect the feeling of use such as washing up and moist feeling depending on the type and blending amount, but in Patent Document 1, diglycerin is essential, and in Patent Document 2, a plurality of polyhydric alcohols are used in combination. There was a limit to the selection of polyhydric alcohols.
[0008]
[Means for Solving the Problems]
In view of such circumstances, the present inventors have made extensive research efforts, and as a result, surfactin and / or a salt thereof, ethylene glycol monostearate or ethylene glycol distearate, acyl isethione, and a creamy skin cleanser comprising a fatty soap. By blending the acid and / or salt thereof, it has been found that a skin cleanser having further excellent stability and usability can be obtained without limitation of polyhydric alcohol, and the present invention has been completed.
[0009]
Hereinafter, the configuration of the present invention will be described in detail.
[0010]
Surfactin and / or a salt thereof used in the present invention preferably includes surfactin sodium in which R ¹ is L-leucine, R ² is general formula 2, and R ³ is sodium.
[0011]
The blending amount of surfactin and / or a salt thereof used in the present invention is not particularly limited, but is preferably 0.05 to 10% by weight, more preferably 0.1 to 5% by weight.
[0012]
When the blending amount is less than 0.05% by weight, good stability and usability may not be obtained. When the blending amount exceeds 10% by weight, stickiness caused by surfactin and / or a salt thereof is felt, and other components If it decreases, the preparation becomes difficult, and a skin cleanser with good usability may not be obtained.
[0013]
The acyl isethionic acid and / or salt thereof used in the present invention is preferably sodium lauroiylisethionate, sodium myristoyl isethionate, sodium cocoyl isethionate, potassium cocoyl isethionate, cocoyl isethionate ammonium and the like.
[0014]
Here, “cocoyl” is an acyl group derived from a fatty acid derived from coconut oil, and the fatty acid generally contains about 50% by weight of lauric acid, and 20-40% of myristic acid, palmitic acid, and stearic acid. % And a mixture of fatty acids having 6 to 18 carbon atoms.
[0015]
The amount of acylisethionic acid and / or salt thereof used in the present invention is not particularly limited, but is preferably 0.5 to 15% by weight, more preferably 1 to 10% by weight. When the blending amount is less than 0.5% by weight, there is no contribution of further good stability and usability, and when it exceeds 15% by weight, the stability may be poor.
[0016]
The skin cleansing composition comprising the fatty soap of the present invention does not impair the effects of the invention. Ingredients, and further ingredients used in foods can be blended. For example, surfactant, oil component, lipid, moisturizer, thickener, medicinal component, bactericidal / preservative, pigment, powder, pH adjuster, ultraviolet absorber, antioxidant, plasticizer, fragrance, amino acid, sweetness A coloring agent, a coloring agent, etc. can be mix | blended suitably.
[0017]
Specifically, as the surfactant, for example, anionic surfactants such as fatty acid soap, N-acyl glutamate, N-acyl alanine salt, N-acyl methyl taurate, alkyldimethylaminoacetic acid betaine, soybean phospholipid, etc. Amphoteric surfactants, cationic surfactants such as alkyltrimethylammonium chloride, and nonionic surfactants such as polyglycerin fatty acid esters and polyethylene glycol difatty acid esters. Examples of the oil component include liquid paraffin, petrolatum, microcrystalline wax, squalane, jojoba oil, beeswax, carnauba wax, lanolin, olive oil, coconut oil, higher alcohol, fatty acid, ester of higher alcohol and fatty acid, silicone oil, and the like. Examples of the humectant include glycerin, sorbitol, xylitol, maltitol, propylene glycol, polyethylene glycol, 1,3-butylene glycol and the like. Examples of the thickening agent include clay minerals such as xanthan gum, methyl cellulose, polyvinyl pyrrolidone, gelatin and bentonite. Examples of medicinal ingredients include various vitamins and derivatives thereof, allantoin, glycyrrhizic acid and derivatives thereof, and various animal and plant extracts.
[0018]
【Effect of the invention】
Next, although an example is given in order to explain the present invention in detail, the present invention is not limited to these. All percentages in the examples are% by weight.
[0019]
In the following examples, surfactin sodium was used as surfactin and / or its salt, and sodium cocoyl isethionate was used as acyl isethionic acid and / or its salt.
[0020]
Using sodium cocoyl isethionate, the skin cleansing agent shown in Example 1 shown below was prepared and evaluated for usability and stability. In addition, as a comparative example, in Example 1, sodium cocoyl isethionate was replaced with purified water (Comparative Example 1).
[0021]
Example 1
weight%
1. Lauric acid 5.0
2. Myristic acid 20.0
3. Palmitic acid 10.0
4). Ethylene glycol distearate 1.5
5. Sodium cocoyl isethionate 2.0
6). Glycerin 10.0
7). Diglycerin 5.0
8). Sodium polyphosphate 0.1
9. Perfume Trace amount 10. Purified water residue 11. Surfactin sodium 0.5
12 Potassium hydroxide 8.0
Production method: Components 1 to 9 are heated and dissolved at 80 ° C., and components 11 and 12 previously dissolved in component 10 are gradually added. Then, it cooled and prepared to 30 degreeC.
[0022]
Usability tests were conducted on 20 women aged 20 to 50 years for the fineness of foam, the water falling off during washing, and the moist feeling after washing. The results are shown in Table 1.
[0023]
[Table 1]
[0024]
As stability, the prepared skin cleanser was allowed to stand at room temperature, 40 ° C. and 4 ° C., and the change in the state after one month was observed. The results are shown in Table 2.
[0025]
[Table 2]
[0026]
◎: Almost the same as that immediately after production. Good: Hardness slightly changes compared to immediately after manufacture, but no problem in use. △: Hardness changes compared to immediately after manufacture, and somewhat difficult in use. Or the hardness changes significantly and there is a problem with stability. [0027]
As shown in Tables 1 and 2, it was revealed that the skin cleanser containing acylisethionic acid as shown in Example 1 was superior in usability and stability as compared with the comparative example.
[0028]
A skin cleanser having a blending composition in which the blending amount of surfactin was varied from the formulation of Example 2 shown below was evaluated for usability and stability.

Example 2
weight%
1. Myristic acid 24.0
2. Palmitic acid 8.0
3. Ethylene glycol monostearate 2.0
4). Lauric acid maltitol ester 3.0
5. Glycerin 10.0
6). Diglycerin 3.0
7). Sodium polyphosphate 0.1
8). Perfume Trace amount 9. Purified water remaining 10. Surfactin sodium 0-15
11. Potassium hydroxide 6.4
[0029]
Production method: Components 1 to 9 are heated and dissolved at 80 ° C., and components 11 and 12 previously dissolved in component 10 are gradually added. Then, it cooled and prepared to 30 degreeC.
[0030]
Usability was evaluated comprehensively based on the following criteria, such as fineness of foam, water loss during washing, and moist feeling after washing.
◎: Very satisfied ○: Satisfied △: Normal ×: Somewhat dissatisfied, dissatisfied [0031]
Stability was evaluated by the following criteria by leaving the prepared skin cleansing material at 40 ° C., observing changes in the state after one month.
◎: Almost the same as that immediately after production. Good: Hardness slightly changes compared to immediately after manufacture, but no problem in use. △: Hardness changes compared to immediately after manufacture, and somewhat difficult in use. Or the hardness changes significantly and there is a problem with stability. [0032]
The results of Example 2 are shown in Table 3.
[0033]
[Table 3]
[0034]
As shown in Table 3, it was revealed that the preferred blending amount of surfactin in the present invention is 0.05 to 10% by weight, more preferably 0.1 to 5% by weight.
[0035]
A skin cleanser having a blending composition in which the blending amount of acyl isethionic acid was changed from the formulation of Example 3 shown below was prepared, and usability and stability were evaluated.
[0036]
Example 3
weight%
1. Lauric acid 3.5
2. Myristic acid 14.0
3. Palmitic acid 7.0
4). Ethylene glycol monostearate 1.0
5. Sodium cocoyl isethionate 0-20
6). Glycerin 8.0
7). Diglycerin 5.0
8). Sodium polyphosphate 0.1
9. Perfume Trace amount 10. Purified water residue 11. Surfactin sodium 0.5
12 Potassium hydroxide 5.6
[0037]
Production method: Components 1 to 9 are heated and dissolved at 80 ° C., and components 11 and 12 previously dissolved in component 10 are gradually added. Then, it cooled and prepared to 30 degreeC.
[0038]
Usability was evaluated comprehensively based on the following criteria, such as fineness of foam, water loss during washing, and moist feeling after washing.
◎: Very satisfied ○: Satisfied △: Normal ×: Somewhat dissatisfied, dissatisfied [0039]
Stability was evaluated by the following criteria by leaving the prepared skin cleansing material at 40 ° C., observing changes in the state after one month.
◎: Almost the same as that immediately after production. Good: Hardness slightly changes compared to immediately after manufacture, but no problem in use. △: Hardness changes compared to immediately after manufacture, and somewhat difficult in use. Or the hardness changes significantly and there is a problem with stability.
The results of Example 3 are shown in Table 4.
[0041]
[Table 4]
[0042]
As shown in Table 4, it was found that the preferred amount of acyl isethionic acid in the present invention is 0.5 to 15% by weight, more preferably 1 to 10% by weight.
[0043]
Example 4
weight%
1. Lauric acid 5.0
2. Myristic acid 18.0
3. Palmitic acid 4.0
4). Behenic acid 2.0
5. Ethylene glycol monostearate 1.0
6). Sodium cocoyl isethionate 2.5
7). Lauric acid monoethanolamide 1.0
8). Glycerin 10.0
9. Sodium polyphosphate 0.1
10. Fragrance 11 Purified water Residual 12. Surfactin sodium 0.5
13. Potassium hydroxide 8.0
[0044]
Production method: Components 1 to 10 are dissolved by heating at 80 ° C., and components 12 and 13 previously dissolved in component 11 are gradually added. Then, it cooled and prepared to 30 degreeC.
[0045]
Example 5
weight%
1. N-lauroyl-potassium L-glutamate 40.0
2. Potassium myristate 2.0
3. Lauric acid monoethanolamide 2.0
4). Ethylene glycol monostearate 2.0
5. Sodium cocoyl isethionate 3.0
6). Lauric acid monoethanolamide 1.0
7). Perfume Trace amount 8. Purified water residue 9. Surfactin sodium 0.5
10. Glycerin 10.0
11. 1,3-B. G 10.0
[0046]
Production method: Component 9 is dissolved in component 8 in advance, and components 10 and 11 are added. Further, components 1 to 7 are gradually added and heated to 80 ° C. to dissolve. Then, it cooled and prepared to 35 degreeC.
[0047]
It was revealed that the skin cleanser comprising the fatty soap according to the present invention obtained in Examples 4 and 5 has good usability and stability.
[0048]
As described above, according to the present invention, a skin cleansing agent having good stability and usability can be obtained by blending surfactin and / or a salt thereof, acylisethionic acid and / or a salt thereof. it can.

Claims (7)

A creamy skin cleanser comprising the following components (A), (B) , (C) and (D) .
(A) Surfactin of general formula 1 (R ¹ is an amino acid, R ² is alkyl, R ³ is a hydrogen atom, an alkali metal, ammonium or an organic amine),
(B) ethylene glycol monostearate or ethylene glycol distearate,
(C) Acyl isethionic acid and / or a salt thereof of general formula 3 (R is a saturated or unsaturated hydrocarbon having 9 to 17 carbon atoms, Z is a hydrogen atom, an alkali metal, ammonium or an organic amine)
(D) Fatty acid soap containing lauric acid, myristic acid or palmitic acid
General formula 1
[Chemical 3]
General formula 3
The skin cleanser according to claim 1, wherein R ^{1 in the} general formula 1 is an amino acid selected from L-leucine, L-isoleucine, and L-valine, and R ² is a C _{8 to} C ₂₂ alkyl. Fee. The skin cleansing composition according to claim 1, wherein R ^{1 in the} general formula 1 is L-leucine, R ² is the general formula 2, and R ³ is sodium.
[Chemical formula 2]
General formula 2
The skin cleansing material according to any one of claims 1 to 3, wherein the amount of the surfactin of the general formula 1 and / or a salt thereof is 0.05 to 10% by weight. The skin cleansing material according to any one of claims 1 to 4, wherein the amount of the surfactin of the general formula 1 and / or a salt thereof is 0.1 to 5% by weight. The skin cleanser according to any one of claims 1 to 5, wherein the amount of acylisethionic acid of general formula 3 and / or a salt thereof is 0.5 to 15% by weight. The skin cleansing agent according to any one of claims 1 to 6, wherein the amount of the acylisethionic acid of the general formula 3 and / or a salt thereof is 1 to 10% by weight.