JP4796307B2 - Nozzle hole structure for dripping, dripping nozzle having this nozzle hole structure - Google Patents

Description

  The present invention relates to a nozzle hole structure used for dropping a liquid like an eye drop nozzle used when, for example, a drug solution is dropped onto an eyeball, and a dropping nozzle having such a nozzle hole structure.

  As a dripping nozzle hole structure, for example, a nozzle hole structure formed as described above has been conventionally known. Such an ophthalmic nozzle is configured as an ophthalmic container by being attached to the mouth of a container body loaded with a chemical solution. At the time of dripping, the patient to be dripped holds the eye drop container and holds it on the eyeball in an inverted state. By pressing (squeezing) the container body, a drop is formed at the outlet opening of the eye drop nozzle, and this is applied to the eyeball. It is used in the form of dripping administration.

  Such eye drop nozzles include a first chamber that opens to the container body side at the lower end (inlet) of the nozzle hole, a second chamber that opens to the outside at the upper end (outlet) of the nozzle hole, and the first and second chambers. The nozzle hole is composed of a small-diameter throttle chamber communicating with each other (Patent Document 1), and the nozzle is formed so as to widen from the lower end (inlet) of the inner nozzle hole to the upper end (outlet) of the outer nozzle hole. There is known one having a larger diameter at the upper end of the hole (Patent Document 2).

JP 7-275322 A JP 2000-25778 A

  By the way, in the eye drop container as described above, in order to cure the disease surely, the chemical solution must be administered in a prescribed amount according to the drug design, and thus the size of the droplet formed at the tip of the eye drop nozzle Therefore, it is necessary to form a certain size regardless of the state of use of the eye drop container, and to reliably administer a certain amount of drug solution. The size of the droplet is selected and determined from the amount of the chemical to be administered, and the shape of the nozzle hole tip (mainly the opening diameter of the outlet at the tip) is determined from the determined droplet size. become.

  However, a droplet can maintain a stable volume only when the inside of the droplet is filled only with a chemical solution. If bubbles are included inside the droplet, the amount of the chemical solution for that single droplet is In addition to being less than the prescribed amount, the bubbles are repelled on the eyeball. As a result, the dose of the drug solution varies in an unstable manner. Furthermore, the amount of squeeze operation increases by the amount of bubbles contained.

  In order to fill the inside of the droplet with the chemical, it is necessary to control the chemical to a viscosity that does not generate bubbles in the chemical, but even if there are no bubbles in the chemical, the vicinity of the opening at the proximal end of the nozzle hole If bubbles are attached to the nozzle hole, the bubbles ride on the flow of the chemical solution from the inside of the container body toward the nozzle hole tip side, that is, entangled in the chemical solution and pushed out to the nozzle hole tip, the liquid formed at the nozzle hole tip It will be mixed inside the droplet.

  Here, when the eye drop container is turned upside down and dropped onto the eyeball to release the squeeze operation on the container body, the squeeze return (elastic restoration of the container body) causes at least the same volume as the amount of the discharged liquid chemical The outside air passes through the nozzle hole from the distal end to the proximal end and is always sucked into the container. At this time, since the container body is in an inverted state and the opening at the proximal end of the nozzle hole is immersed in the chemical solution, the outside air that is sucked in and flows in is in the form of bubbles and bubbles are necessarily formed. become. If bubbles generated by the inflow of outside air adhere to the outer periphery of the opening at the base end of the nozzle hole, the bubbles are mixed into the droplets as described above when the squeezing operation is continued again.

  Also, even if the instillation operation is interrupted and the container is restored to the upright state and stored or carried in this upright state, the liquid level of the chemical liquid is bubbled due to the influence of vibration, etc. As a result, when the liquid crystal is turned upside down for dripping, bubbles are mixed into the liquid droplet in the same manner as described above. Furthermore, when the liquid is inverted for the dripping operation, the inside of the container expands due to the warmth of the hand that holds the container body, and even if the squeeze operation as described above is not performed, the chemical liquid entrains the bubbles and bubbles into the droplets. Can also be mixed.

  The present invention has been made in view of such circumstances, and the object of the present invention is to ensure that the volume of droplets to be dropped is constant by reliably suppressing and preventing the mixing of bubbles. It is an object of the present invention to provide a dripping nozzle hole structure that can be maintained and guaranteed and a dripping nozzle having this nozzle hole structure.

In order to achieve the above object, in the invention relating to the dropping nozzle hole structure, the mouth of the container main body to which the liquid is loaded is closed, and the inside and the outside of the container main body communicate with each other only by the nozzle hole. The following specific matters are provided for a dropping nozzle hole structure configured such that droplets are formed at the outlet portion of the nozzle hole opening in the nozzle hole. That is, the nozzle hole, the inlet portion of that is extended downward to the opening portion so as to open facing the internal space of the container body at one end position, the outlet portion at the other end position is outside of the container body The inner diameter of the nozzle hole from the outlet section to the inner diameter abruptly changing portion in the immediate vicinity of the inlet section is maintained substantially the same, or is very slight in order to facilitate die cutting during synthetic resin molding Of the liquid containing bubbles that are sucked into the nozzle hole by squeeze return when the container body is turned upside down and the squeeze operation applied for droplet administration is released. In order to increase the flow velocity and divide and reduce the diameter of the bubbles, the diameter is suddenly reduced at the site where the inner diameter suddenly changes to reach the opening of the inlet portion having the smallest opening diameter in the range of 0.1 mm to 0.5 mm. Until The inner surface of serial inner diameter sudden change portion is formed so as smoothly changes, the entrance portion outer peripheral surface of the cylindrical wall which constitutes the formed conically to pointed toward the container body inside, the opening of the upper fill opening and this opening was to form such that the apex toward the tip formed on the container body inner side by the opening surface formed from an opening edge surrounding the (claim 1).

In the case of the invention related to the nozzle hole structure, when the container body is inverted from the upright position to the upside down position and squeezed from the upside down position, liquid droplets are formed at the outlet portion by the liquid flowing into the nozzle hole from the inlet portion of the nozzle hole. This is dripped. After dropping, when the squeeze is released in the inverted state, the same amount of outside air as the droplet is sucked into the nozzle hole by the squeeze return, but the inner diameter of the inlet is rapidly reduced to the minimum diameter. In addition to being divided into extremely small bubbles corresponding to the minimum diameter, the above-mentioned small bubbles pass at a high speed through the opening of the inlet portion due to a rapid increase in the flow velocity of the counter-current liquid passing therethrough. Adhesion will be prevented. In other words, the risk of adhesion due to bubble contact with the periphery of the inlet portion or the inner surface of the inlet portion is made difficult to attach by forcibly dividing the bubble size to a size corresponding to the minimum diameter as described above, or It is prevented by increasing the passage flow velocity at the inlet portion at a high speed to make it difficult to stick. Furthermore, since the outer peripheral surface of the cylindrical wall constituting the inlet portion is formed in a conical shape and the tip of the inlet portion is formed to be sharp , air bubbles that have come out of the inlet portion together with the backflow liquid It becomes difficult to maintain contact with the vicinity of the opening edge, and the contact can be easily cut off. Also by this, it is possible to further suppress / prevent the adhesion of bubbles to the inlet portion. And since such an inlet part is positioned so as to open facing the internal space of the container body by extending the nozzle hole, the liquid of the liquid in the container body does not stagnate from the inverted inlet part. It is possible to jump out to the surface immediately. As a result, it is possible to reliably prevent and suppress the adhesion of bubbles due to outside air suction due to squeeze return, and to prevent bubbles from being mixed into the droplets formed by the next dropping operation. The drop volume can be reliably maintained and guaranteed. Therefore, if it is applied to an eye drop container for eye drops, the amount of the medicinal solution that is dropped onto the patient's eyeball can be reliably maintained at a constant amount.

Further, since the inner surface of the inner 径急 variable sites in the inlet portion is formed so as to vary smoothly up to the opening of the inlet portion of the minimum opening diameter of 0.1 mm to 0.5 mm, dribbling operation Turbulent flow of the liquid passing through the squeeze can be suppressed, but when the outside air is sucked with the squeeze return, the degree of compression of the outside air due to the sudden decrease in the inner cross section can be reduced as much as possible. The degree of expansion due to the rapid expansion of the cross section is weakened so that the bubble size (bubble diameter) can be kept small.

In this case, the opening diameter of the inlet portion is preferably as small as possible from the viewpoints of minimizing the bubble size and increasing the passage flow velocity. Here, “0.1 mm” is, for example, a lower limit value in manufacturing in the case of synthetic resin molding, and “0.2 mm” is more preferable in manufacturing. The upper limit value of “0.5 mm” is a value selected from the viewpoint of making it difficult for bubbles to be attached by reducing the bubble size and increasing the flow velocity of the passage. Is most preferably “0.3 mm to 0.4 mm” or “0.3 mm to 0.5 mm”. Furthermore, in these cases, by maintaining the inner diameter from the outlet portion of the nozzle hole to the inner diameter suddenly changing portion at the position closest to the inlet portion, only the inlet portion has the smallest opening diameter and extends to the outlet portion. It is possible to secure a sufficient volume in the other nozzle holes. For this reason, it is possible to avoid or suppress the risk that the liquid inside the liquid expands due to the warmth of the hand holding the container main body and the liquid droplets are formed and dropped without being squeezed in an inverted state. That is, the above-mentioned expansion is absorbed by a sufficient volume in the nozzle hole and acts on the side that prevents the formation of droplets accompanying expansion.

In the present invention described above, the diameter of the opening surface (the portion formed by the opening of the inlet portion and the opening edge thereof to be a tip) is 0.0 to 0.4 mm with respect to the opening diameter of the inlet portion. can be limited such that (claim 2). In the case of “0.0 mm”, that is, a state in which the opening edge has an acute angle and no sharp width is preferable in order to make it difficult to attach bubbles. For example, in the case of synthetic resin molding, it is possible to sharpen at an acute angle. However, the presence of a flat portion having a small width as an opening edge increases the certainty in manufacturing, and a certain small width. If it is up to, it is considered that the difficulty of air bubbles can be maintained. This upper limit is “0.4 mm”.

Further, the outer peripheral surface of the cylindrical wall constituting the inlet portion, the included angle can it to form a conical shape in the range of 60 to 90 degrees (請 Motomeko 3). From the viewpoint of preventing air bubbles from adhering to the outer peripheral surface of the inlet portion, “90 degrees” is selected as the upper limit value, and the smaller the included angle value , the better . On the other hand, if the angle is too acute, for example, there is a problem that the resin material does not wrap around at the time of manufacturing by synthetic resin molding, resulting in molding failure, and “60 degrees” is selected as the lower limit value that does not cause such manufacturing problems. . Further, it is preferable that at least 0.3 mm of such a conical outer peripheral surface exists in the longitudinal direction of the cylindrical wall from the inlet. In relation to the reduction in bubble size due to the opening diameter of the inlet, the range in which the reduced bubble may come into contact is reduced to the above-mentioned size in order to prevent adhesion by making it a conical outer peripheral surface. “0.3 mm or more” is adopted based on the size of the air bubbles.

On the other hand, in the invention concerning a dropping nozzle, it has the nozzle hole structure for dropping according to any one of claims 1 to 3 for a dropping nozzle built in the mouth of a container body loaded with liquid. A nozzle hole is provided (claim 4 ). In the case of such a dripping nozzle, various actions as described above can be obtained.

And it is provided with the cylindrical outer wall inserted with respect to this dripping nozzle with respect to the inner surface of the opening | mouth part of the said container main body, and the cylindrical wall which forms a nozzle hole inside this outer wall, The said cylindrical wall is provided with the said outer wall. You may make it extend to the position of the lower end vicinity of the outer wall in the range which does not protrude from a lower end (Claim 5 ). Specifically, it is preferable to set the allowable displacement between the lower end of the cylindrical wall and the lower end position of the outer wall in a range of 0.0 mm to 2.0 mm. In the case of “0.0 mm”, that is, extending the lower end of the cylindrical wall to a position that coincides with the lower end position of the outer wall is not completely upside down in the inverted state but in the inclined state. It is most preferable when it is expelled to the liquid level without adhering to the space between them, but when considering eye drops as an application, a large number of dripping nozzles are used when storing and holding a large number of dripping nozzles on the assembly production line. There is a possibility that the entrance portion located at the opening at the lower end of the outer wall may be damaged due to interference with each other and other parts. For this reason, it is preferable in manufacturing that the lower end of the cylindrical wall is positioned slightly deeper than the lower end of the outer wall. On the other hand, if the lower end of the cylindrical wall (that is, the opening of the inlet portion) is too far away from the lower end of the outer wall, it is considered that bubbles are likely to adhere to the gap between the inner surface of the outer wall. “2.0 mm” is adopted as the upper limit value that satisfies both the manufacturing and the function, and the range of 1.0 mm to 1.5 mm is most preferable.

As described above, according to the dropping nozzle hole structure according to any one of claims 1 to 3 , the outside air due to the squeeze return after performing the droplet dropping operation by squeezing in an inverted state. Even if suction occurs, it is possible to reliably prevent and prevent bubbles from adhering to the opening of the inlet and the surroundings, and to avoid the occurrence of bubbles in the droplets formed by the next dripping operation. can do. As a result, it is possible to reliably maintain and guarantee the volume of the liquid droplets to be dripped. For example, when applied to a nozzle hole for medicinal liquid eye drops, the amount of medicinal liquid to be dripped into the patient's eyeball can be reliably ensured. A certain amount can be maintained.

In addition , the generation of turbulent flow of the passing liquid during the dropping operation can be suppressed, while the degree of compression / expansion of the outside air due to sudden decrease / expansion of the inner cross section can be reduced as much as possible when sucking outside air due to squeeze return. Therefore, it is possible to prevent the adhesion of bubbles more reliably.

Then, when the outside air suction by the squeeze back, is sucked from the outlet portion can be separated bubble size leaving the inlet portion to be sufficiently small, it is possible to more reliably prevent the bubble adhesion. Further , it is possible to avoid / suppress the possibility that the liquid inside the liquid expands due to the warmth of the hand holding the container body and the liquid droplets are formed and dropped without being squeezed in an inverted state.

Further, according to the dropping nozzle of claim 4 or 5 , the various effects described above can be obtained in the dropping nozzle, and in particular, according to claim 5 , the bubble is introduced into the cylinder wall having the inlet portion in the inverted state. It is most preferable for expelling to the liquid level without adhering to the lower end of the tube, and it is also preferable in manufacturing related to mass assembly by positioning the lower end of the cylindrical wall slightly behind the lower end of the outer wall as a nearby position. Can be.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings.

  FIG. 1 shows an instillation nozzle 3 for dripping (dropping) a drug solution onto an eyeball as a dripping nozzle having a nozzle hole structure of the present invention. The instillation nozzle 3 is assembled to a container body 2 to form an instillation container (dropping container). It is composed.

  The eye drop container is composed of a container main body 2 in which a predetermined amount (for example, 5 mL: milliliter) of a medicinal solution Y for eye drops is loaded, an eye drop nozzle 3 assembled by press-fitting into the mouth portion 21 of the container main body 2, and the mouth portion. And a protective cap 22 that is screwed into 21 to protect the eye drop nozzle 3.

  The container body 2 is formed into a flexible bottle shape so that its body portion can be squeezed by predetermined synthetic resin molding, and a screw thread portion is formed on the outer peripheral surface of the mouth portion 21. Yes. The protective cap 22 is also formed by synthetic resin molding, and has a screw thread portion that can be attached and detached by screwing into the screw thread portion of the outer peripheral surface of the mouth portion 21 on the inner peripheral surface. A spherical convex portion 221 is formed that can be fitted into the tip opening of 312 and hermetically sealed. The protective cap 22 closes the outlet portion 312 with the convex portion 221 and closes the upper surface of the flange portion 33 and the screw thread portion in the closed state (the state shown in FIG. 1) screwed into the mouth portion 21. The container main body 2 can be sealed by being in close contact with any one or more.

  As shown in detail in FIG. 2, the eye drop nozzle 3 includes a cylindrical wall 32 in which a nozzle hole 31 is formed, a flange portion 33 that protrudes from an intermediate position in the vertical direction of the cylindrical wall 32 to the outer peripheral side, A substantially cylindrical outer wall (referred to as a so-called “foot” or “medium foot”) 34 that surrounds the lower half of the cylindrical wall 32 and projects downward from the flange 33 is integrally provided. Such an eye drop nozzle 3 is integrally formed by synthetic resin molding using, for example, low density polyethylene or the like. The cylindrical wall 32 has an upper half portion 32a formed in a substantially conical shape or a dome shape with the flange portion 33 as a boundary, and is disposed outside the mouth portion 21, and a lower half portion 32b is formed in a cylindrical shape. It protrudes to the position near the lower end of the outer wall 34 at the inner position of the outer wall 34 and is arranged in the mouth portion 21. A nozzle hole 31 extends vertically through the cylindrical wall 32. The flange portion 33 is formed in a shape corresponding to the upper surface of the mouth portion 21 and comes into contact with the upper surface of the mouth portion 21 in the assembled state. Further, the outer wall 34 is assembled in a state where the outer peripheral surface thereof is hermetically press-fitted into the inner peripheral surface of the mouth portion 21 and the mouth portion 21 is closed. The nozzle hole 31, the cylindrical wall 32, the flange portion 33, and the outer wall 34 are formed in a coaxial arrangement in this embodiment.

  The nozzle hole 31 faces the internal space of the container body 2 at the lower end position of the cylindrical wall 32, and the inlet portion 311 opens. The nozzle hole 31 faces the outside at the upper end position of the cylindrical wall 32 and opens the outlet portion 312. The lower end of the cylindrical wall 32 where the inlet 311 opens, that is, the lower end of the lower half 32b is extended to the same position as the lower end of the outer wall 34 or slightly to the upper position. Although it is preferable to arrange the inlet portion 311 at a position facing the inner space of the container body 2 more closely, the presence of protrusions from the lower end of the outer wall 34 is eliminated to improve handling during assembly or inadvertently. In order to prevent damage, the inlet 311 is allowed to be disposed at a position slightly behind the lower end of the outer wall 34. In this case, the allowable displacement H with respect to the lower end of the outer wall 34 is in the range of 0.0 to 2.0 mm, preferably 0.0 to 1.5 mm or 0.0 to 1.0 mm. Among them, the inlet portion 311 is arranged at a position facing the inner space of the container body 2 closer, that is, the lower end of the inlet portion 311 is extended to the same level position as the lower end of the outer wall 34 or as close as possible to the level position. 1.0 mm as an allowable range H that satisfies both the functional requirement of preventing bubbles from adhering and the manufacturing requirement of improving the handling property and preventing inadvertent damage during assembly manufacturing. A range of ˜1.5 mm is most preferred.

  The opening diameter D of the outlet 312 is set so that a predetermined volume of liquid droplets is formed according to the amount of the chemical to be instilled. For example, when the volume of the droplet is 35 μL (microliter), the opening diameter D is set to 2.3 mm. The nozzle hole 31 is maintained substantially the same as the opening diameter D of the outlet portion 312 from the outlet portion 312 to the inner diameter suddenly changing portion 313 immediately adjacent to the inlet portion 311 or from the opening diameter D of the outlet portion 312. The inner diameter is formed so as to gradually decrease little by little up to the inner diameter suddenly changing portion 313. The reason why the inner diameter is gradually reduced is to facilitate die-cutting during the molding of synthetic resin, and it is preferable to set the same as the opening diameter D of the outlet portion 312 in terms of securing the volume.

The abrupt inner diameter changing portion 313 is provided for abruptly reducing the diameter from the opening diameter D of the outlet portion 312 to the minimum opening diameter d of the inlet portion 311, and the inner surface is curved smoothly. Is formed. That is, as illustrated in FIG. 2, the inner diameter suddenly changing portion 313 includes a concave round portion c1 having a center inside the nozzle hole 31, a convex round portion c2 having a center located outside the nozzle hole 31, and a funnel downward. And a circular hole c4 having a uniform inner diameter with an opening diameter d of the opening 314 are formed smoothly and continuously. Specific examples include a radius of 0.5 mm or more as the concave radius c1, a radius of 0.5 mm or more as the convex radius c2, and a taper of 3 degrees with respect to the vertical direction as the taper c3. The opening diameter d of the inlet portion 311 may be selected from the range of 0.1 mm to 0.5 mm, and d = 0.4 mm if priority is given to manufacturing ease of synthetic resin molding while satisfying the reduction in bubble diameter. Are preferable, and then d = 0.3 mm and 0.2 mm.

  On the other hand, on the outer surface side of the inlet portion 311, the outer peripheral surface 321 at the lower end of the cylindrical wall lower half portion 32 b is formed in a conical shape that is pointed downward at a predetermined narrow angle α or less. The pointed end is constituted by an opening surface 316 including an opening 314 having the opening diameter d and an opening edge 315 surrounding the opening 314. The opening surface 316 is equal to the opening diameter d, that is, the opening edge 315 has a sharp edge with no width, so that the bubbles can be prevented from sticking and can be removed immediately even when contacted. desirable. From this point of view, the allowable width of the opening edge 315 is about 0.2 mm, and the relationship between the diameter b of the opening surface 316 and the opening diameter d of the opening 314 is in the range of d to (d + 0.4 mm). Will be limited. The outer peripheral surface 321 is formed as a conical slope having an included angle α in the range of 60 ° to 90 ° (inclination range of 30 ° to 45 ° with respect to the vertical direction), and the boundary with the upper wall surface 322 is also formed. It is smoothly connected via a convex radius portion c5 of 0.5 mm radius or more.

  In order to instill using the above eye drop container, the container body 2 is squeezed (see the one-dot chain line in FIG. 3) after being placed in an inverted state as shown in FIG. The droplet y formed in the part 312 is dropped into the eyeball. When the squeeze operation is released, the outside air is sucked into the nozzle hole 31 from the outlet portion 312 by the squeeze return, and this becomes bubbles S and moves to the inlet portion 311 side together with the chemical solution. When the bubbles S reach the inner diameter suddenly changing portion 313, the flow rate is rapidly increased, while the bubbles S are divided and the bubble size is reduced to correspond to the opening diameter d of the opening 314. For this reason, the bubbles Sd, Sd,..., Which have been reduced in diameter and divided into a plurality of parts, rush out of the opening 314 and rise to the liquid level of the drug solution Y to be opened. That is, by increasing the flow velocity and dividing and reducing the diameter of the bubbles, it is possible to reliably prevent bubbles from adhering to and remaining around the inlet portion 311. Even if the dropping operation is performed not in an inverted state but in a considerably oblique state (for example, 45 degrees obliquely), the lower end of the cylindrical wall 32 is extended to a position in the vicinity of the lower end of the outer wall 34 and the vicinity of the lower end of the mouth portion 21. Since the inlet portion 311 is positioned at the top, the bubbles popping out from the inlet portion 311 due to the speed increase and the division / thinning increase to the liquid level without contacting or adhering to the inner surface of the outer wall 34 or the like. Will be released.

On the other hand, even if bubbles are generated due to vibration during carrying or the like and bubbles are likely to contact or adhere to the inlet portion 311, the opening surface 316 of the inlet portion 311 is pointed and the outer peripheral surface 321 following this is formed in a conical shape. Therefore, the contact is immediately disconnected without sustaining the contact, and the bubbles are detached, so that the bubbles can be prevented from adhering to the inlet portion 311. Further, since the end of the conical outer peripheral surface 321 is smoothly formed by the convex rounded portion c5, separation and separation of the contacted / attached bubbles are promoted to prevent adhesion.

  As a result of preventing the occurrence of bubble adhesion as described above and avoiding bubble mixing in the droplets, the amount of the chemical liquid in the formed droplets can be reliably maintained and guaranteed.

<Other embodiments>
In addition, this invention is not limited to the said embodiment, Various other embodiments are included. That is, in the embodiment, the standard eye drop nozzle 3 applied to the container body 2 in which the mouth portion 21 has a relatively narrow neck shape is shown, but FIG. 4 is applied to the case where the mouth portion has a large diameter. FIG. 5 shows an eye drop nozzle (dropping nozzle) 3b that is applied when the mouth portion has a very narrow diameter. The outer diameter of the outer wall 34 may be changed and set for the large-diameter mouth portion of FIG. 4, and the outer diameter may be changed and set for the small-diameter mouth portion of FIG. FIG. 5 shows an example in which the inner diameter of the nozzle hole 31 is made equal to the opening diameter of the outlet portion 312 except for the inlet portion 311.

  In the above embodiment, the dropping nozzle (eye drop nozzle) and the container main body are shown separately from each other. However, the present invention is not limited to this, and both may be integrally molded with synthetic resin. In this case, filling of the internal chemical solution and integral molding with the synthetic resin may be performed simultaneously. Even in such a case, by providing the nozzle hole structure of the present invention, it is possible to prevent bubbles from adhering to the periphery of the inlet portion, thereby preventing bubbles from being mixed into the droplets. The effect | action and effect of this invention of obtaining can be acquired.

  Using a chemical solution having a surface tension of 450 μN / cm, a drop performance test is performed using an eye drop container (three kinds of examples described later) having an eye drop nozzle having the structure of the above embodiment (see FIGS. 1 and 2). Thus, the action and effect of the present invention were confirmed. In the drop performance test, the dropper was dropped 20 times by changing the eye drop container from an upright state to an inverted state, and the drop amount of each drop was measured. The number of bubbles (number of bubbles) by which the bubbles popping out from the inlet 311 were divided and divided by one external air suction corresponding to the droplets was measured. Further, in addition to the inverted state (90 degrees with respect to the horizontal plane), the number of bubbles attached to the periphery of the inlet portion 311 was measured by the outside air suction by the squeeze return when inclined at 45 degrees and 60 degrees with respect to the horizontal plane. The results of this dropping performance test are shown in Table 1.

  The test specimens used were of three types, Example 1, Example 2 and Example 3. Each of these specimens (opening diameter D of outlet 312, opening diameter d of inlet 311 and displacement from the lower end of outer wall 34). H and the included angle α) of the outer peripheral surface 321 are shown in Table 2. In addition, as specifications which do not appear in Table 2, the concave radius c1 of the inner diameter sudden change site 313 is 0.8 mm radius and the convex radius c2 is 0.5 mm radius in the three types of embodiments, and on the outer peripheral surface side. The convex round part c5 is set to 1.0 mm. Incidentally, Example 1 will be described as an example in Table 2. In Example 1, the opening diameter D of the outlet portion 312 is set to 2. using the chemical liquid having the above surface tension so that the size of the droplet is 35 μL. 3 mm was selected, 0.3 mm was selected as the opening diameter d of the inlet portion 311, the displacement H from the lower end of the outer wall 34 was 1.0 mm, and the included angle α of the outer peripheral surface 321 of the inlet portion 311 was 90 degrees.

  According to the test results in Table 1, the target dripping amount is consistent with the average value of the measured values in any of Examples 1 to 3, and a certain amount of droplets were formed and dripped almost certainly. Conceivable. In addition, even during squeeze-returned outside air suction, the bubbles that have popped out from the inlet 311 are divided into three or more outside air suctions of a volume corresponding to one droplet, and always become three or more bubbles. It was possible to obtain bubbles with a diameter of 3 or less. In addition, even after dropping by 45 degrees and sucking outside air by squeezing back, the number of bubbles attached to the inlet 311 and the outer peripheral surface 321 was zero, and no bubbles were attached.

It is a section explanatory view of an eye drop container to which an embodiment of the present invention is applied. FIG. 2 is an enlarged explanatory view of the eye drop nozzle of FIG. 1. It is a cross-sectional explanatory drawing at the time of making the eye drop container of FIG. 1 into an inverted state. It is a cross-sectional explanatory drawing of the eye drop nozzle of the form different from FIG. FIG. 5 is a cross-sectional explanatory view of an ophthalmic nozzle having a form different from that of FIGS.

Explanation of symbols

2 Container body 3, 3a, 3b Instillation nozzle (dropping nozzle)
21 mouth portion 31 nozzle hole 32 cylindrical wall 34 outer wall 311 inlet portion 312 outlet portion 313 inner diameter sudden change portion 314 opening 315 opening edge 316 opening surface 321 outer peripheral surface Y of inlet portion chemical (liquid)
y droplet

Claims (5)

The mouth of the container body into which the liquid is loaded is closed, the interior and exterior of the container body are communicated only by the nozzle holes, and droplets are formed at the outlets of the nozzle holes that open to the outside. In the nozzle hole structure for dripping,
The nozzle openings, the inlet portion of its one end position is extended to the opening portion so as to open facing the internal space of the container body downwards, outside of the outlet portion the container body at the other end position The inner diameter of the nozzle hole from the outlet section to the inner diameter abruptly changing portion in the immediate vicinity of the inlet section is maintained substantially the same, or is very slight in order to facilitate die cutting during synthetic resin molding Of liquid containing bubbles that are formed so as to be gradually decreased, and that are sucked into the nozzle holes by squeeze return when the container body is turned upside down and the squeeze operation applied for droplet administration is released. In order to increase the flow velocity and divide and reduce the diameter of the bubbles, the diameter is suddenly reduced at the inner diameter suddenly changing portion to reach the opening of the inlet portion having the smallest opening diameter in the range of 0.1 mm to 0.5 mm. Up to above径急inner surface of the variable site is formed so as to change smoothly,
The inlet portion the outer peripheral surface of the cylindrical wall which constitutes the is formed in a conical shape pointed toward the inner container body, the opening of the upper fill opening and a tip the container main body constituted by the opening surface formed from an opening edge surrounding the opening toward the inside are formed so as that the apex,
A nozzle hole structure for dropping. The nozzle hole structure for dripping according to claim 1,
A dripping nozzle hole structure in which the opening surface is limited to a diameter in a range of a value obtained by adding 0.0 to 0.4 mm to the opening diameter of the inlet portion. The nozzle hole structure for dripping according to claim 1,
The outer peripheral surface of the cylindrical wall which comprises the said inlet part is the nozzle hole structure for dripping currently formed in the cone shape whose included angle is the range of 60 degree-90 degree | times. A dripping nozzle installed in the mouth of a container body loaded with a liquid,
A nozzle hole having the nozzle hole structure for dropping according to any one of claims 1 to 3 , is provided.
A dripping nozzle characterized by that. The dripping nozzle according to claim 4 ,
A cylindrical outer wall that is inserted into the inner surface of the mouth of the container body, and a cylindrical wall that forms a nozzle hole inside the outer wall,
The dropping nozzle, wherein the cylindrical wall extends to a position near the lower end of the outer wall in a range that does not protrude from the lower end of the outer wall.

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