JP4761756B2 - 2,3-Dihydroimidazo [2,1-b] oxazole compound - Google Patents

Description

  The present invention relates to 2,3-dihydroimidazo [2,1-b] oxazole compounds.

Among mycobacteria, Mycobacterium tuberculosis is widely known, and it is said that one third of humans are infected. In addition, Mycobacterium africanum and Mycobacterium bovis are known as Mycobacterium tuberculosis as well as Mycobacterium tuberculosis, and are known as mycobacteria having strong pathogenicity against humans.

  These tuberculosis are treated with three drugs, rifampicin, isoniazid and ethambutol (or streptomycin), which are positioned as first-line drugs, or four drugs with pyrazinamide added thereto.

  However, because treatment for tuberculosis requires a very long-term medication, compliance is poor and treatment is not uncommon.

  In addition, rifampicin induces liver damage, full syndrome, drug allergy, contraindication with other drugs induced by P450-related enzymes, isoniazid induces peripheral neuropathy, severe liver damage when combined with rifampicin, ethambutol It has been reported that side effects such as decreased visual acuity due to optic neuropathy, streptomycin, decreased hearing due to 8th cranial neuropathy, pyrazinamide, liver damage, gout attacks associated with increased uric acid levels, and vomiting (A Clinician's Guide To Tuberculosis, Michael D. Iseman 2000 by Lippincott Williams & Wilkins, printed in the USA, ISBN 0-7817-1749-3, Tuberculosis 2nd Edition, Fumiyuki Kuze, Takahide Izumi, Medical School 1992).

  Reports that cases where standard chemotherapy cannot be performed due to these side effects accounted for 70% of all patients (about 23%, 52 cases) who were discontinued (all 228 inpatients surveyed) There is also (Kekkaku Vol.74: 77-82, 1999).

  In particular, hepatic toxicity common to rifampicin, isoniazid and pyrazinamide among the five drugs used in combination in the first line is known as the most frequent side effect. On the other hand, tuberculosis bacteria that are resistant to anti-tuberculosis drugs, tuberculosis bacteria that have become multidrug resistant, and the like are increasing, making treatment more difficult.

  According to the WHO survey (1996-1999), among the tuberculosis bacteria isolated in the world, the percentage of resistance to any of the existing anti-tuberculosis drugs has reached 19%, and multidrug-resistant tuberculosis bacteria are also 5. 1% has been announced. It is said that the number of carriers infected with such multidrug-resistant tuberculosis bacteria has reached 60 million worldwide, and there are concerns that the number of multidrug-resistant tuberculosis bacteria will increase in the future (April 2001 as a supplement to the journal Tuberculosis, the "Scientific Blueprint for TB Drug Development").

  Furthermore, most of the causes of death in AIDS patients are tuberculosis, and it has been reported that as of 1997, there were 10.7 million people who were infected with tuberculosis and HIV (Global Alliance for TB drug development). ). It is also believed that mixed infection carries at least 30 times higher risk of developing tuberculosis than usual.

  In view of the current situation, the desired anti-tuberculosis drug profile is as follows: (1) effective against multi-drug resistant tuberculosis, (2) enabling short-term chemotherapy, (3) having few side effects, (4) Those showing efficacy against latently infected tuberculosis bacteria (Lentium tuberculosis), (5) those that can be administered orally, and the like.

In addition, Mycobacterium avium and Mycobacterium intracellulare , which are the causative bacteria of MAC disease (Mycobacterium avium-intracellulare complex disease), which have been increasing in recent years , and other Mycobacterium kansasii , Mycobacterium marinum , Mycobacterium simiae , Mycobacterium scrofulaceum , Mycobacterium szulgai , Mycobacterium szulgai , Mycobacterium szulgai , Mycobacterium x Atypical mycobacteria such as malmoense , Mycobacterium haemophilum , Mycobacterium ulcerans , Mycobacterium shimoidei , Mycobacterium fortuitum , Mycobacterium chelonae , Mycobacterium smegmatis , Mycobacterium aurum and the like are known to be pathogenic to humans.

  Today, there are few promising treatments for these atypical mycobacterial diseases, such as rifampicin, isoniazid, ethambutol, streptomycin, kanamycin, anti-tuberculosis drugs, new quinolone drugs for general bacterial infections, and macrolide antibacterials Currently, a combination of an agent, an aminoglycoside antibacterial agent and a tetracycline antibacterial agent is used.

  However, the treatment of atypical mycobacterial diseases is compelled to be taken for a long time as compared with infections caused by general bacteria, and cases of intractable disease and death have been reported. In order to solve such a current situation, development of a drug exhibiting stronger efficacy is desired.

  For example, in Japanese Patent Publication No. 11-508270 (WO97 / 01562, Patent Document 1), 6-nitro-1,2,3,4-tetrahydro [2,1-b] imidazopyran compound is (H37Rv strain) and multidrug-resistant Mycobacterium tuberculosis have bactericidal action and have a therapeutic effect by oral administration to tuberculosis-infected animal models. Is disclosed.

  However, the compounds described in the above documents are different from the compounds of the present invention in basic skeleton and are dissimilar compounds.

  Furthermore, Kuppsuwamy Nagarajan et al., European Journal of Medicinal Chemistry, 1989, Vol. 24, 631-633 (European Journal of Medicinal Chemistry 1989, Vol. 24, p631-633) Patent Document 1) includes general formula (1).

In the formula, R ¹ represents a hydrogen atom or a methyl group, and — (CH ₂ ) _n R ² is a chloromethyl group, a C1-C7 alkyl group, an isopropoxymethyl group, a 3-propenyloxymethyl group, an unsubstituted phenoxymethyl. A compound showing a group and compounds in which R ¹ and — (CH ₂ ) _n R ² are combined to form a cyclopentane ring or a cyclohexane ring (16 kinds of compounds in total) have a bactericidal action against Mycobacterium tuberculosis (H37Rv strain). Have reported that.

However, in the above document, there are only 4 kinds of compounds effective by oral administration, and among them, the most active compound, that is, R ¹ in formula (1) represents a hydrogen atom, and — (CH ₂ ) Since the mutagenicity was found in the compound (CGI-17341) in which _n R ² is ethyl, there is a description that the development of these series of compounds as a drug was abandoned.

Furthermore, Antimicrovial Agent and Chemotherapy, February 1993, pages 183 to 186 (Dilip R. Astekar et. Al., Antimicrobial Agents and Chemotherapy, Feb. 1993, p183-186) (Non-patent Document 2) Is an antibacterial profile of the above-mentioned CGI-17341, that is, although it has bactericidal action against M. tuberculosis (H37Rv strain) and multidrug-resistant M. tuberculosis, atypical mycobacterial genus M. avium , M. intracellulare And M. fortuitum is reported to have no activity at 250 μg / ml or less.
WO97 / 01562 European Journal of Medicinal Chemistry, 1989, 24, 631-633 Antimicrovial Agent and Chemotherapy, February 1993, pages 183-186

  An object of the present invention is to provide a compound having an excellent bactericidal action against tuberculosis bacteria and multidrug-resistant tuberculosis bacteria.

  An object of the present invention is to provide a compound having an excellent bactericidal action against atypical mycobacteria.

  As a result of intensive studies to solve the above problems, the present inventor has developed a novel 2,3-dihydroimidazo [2 having an excellent bactericidal action against tuberculosis bacteria, multidrug-resistant tuberculosis bacteria and atypical mycobacteria. , 1-b] oxazole compounds were successfully synthesized. The present invention has been completed based on such findings.

The present invention provides the following novel 2,3-dihydroimidazo [2,1-b] oxazole compounds.
1. General formula (1)

[Wherein R ¹ represents a hydrogen atom or a C 1-6 alkyl group.
n shows the integer of 0-6.
R ² represents any one of the following groups (a) to (y).
(A) a phenyl group (on the phenyl ring, at least one piperidyl group [on the piperidine ring, at least one phenoxy group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 A group selected from the group consisting of an alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) may be substituted] may be substituted) ;
(B) a benzothiazolyloxy group (on the benzothiazole ring, (b-1) a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or At least one group selected from the group consisting of substituted C1-6 alkoxy groups may be substituted], (b-2) piperazinyl group [on the piperazine ring, a phenyl C1-6 alkyl group (phenyl On the ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. ), A phenyl C2-6 alkenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) And a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted group). And at least one group selected from the group consisting of a group selected from the group consisting of C1-6 alkoxy groups may be substituted], (b-3 ) Piperidyl group [on the piperidine ring, an amino group (on the amino group, a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1 And at least one group selected from the group consisting of -6 alkoxy groups may be substituted] and at least one group selected from the group consisting of C1-6 alkyl groups may be substituted) , Enoxy group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. And a phenyl C1-6 alkyl group (on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one group selected from the group consisting of: (b-4) a pyrrolyl group [on the pyrrole ring, C1-6 alkyl group and phenyl C1-6 alkyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen At least one group selected from the group consisting of a group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted)] And (b-5) a phenylthio group [on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; At least one of the groups selected from the group consisting of: which may be substituted] may be substituted);
(C) a quinolyloxy group (on the quinoline ring, (c-1) a halogen atom, (c-2) a phenoxy group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen At least one group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted], (c-3) piperazinyl group [on the piperazine ring, phenyl C1-6 alkyl Group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. A phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted group). May be substituted with at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups], halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups, and halogen-substituted or unsubstituted And at least one group selected from the group consisting of C1-6 alkoxy groups may be substituted) and a phenyl C2-6 alkenyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1). At least one group selected from the group consisting of -6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted). And (c-4) piperidyl group [on the piperidine ring, an amino group (on the amino group, a phenyl group [on the phenyl ring, a halogen atom, From at least one group selected from the group consisting of a rogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] and a C1-6 alkyl group At least one group selected from the group may be substituted); a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted; a phenyl C1-6 alkyl group (on the phenyl ring, a C1-4 alkylenedioxy group, a halogen atom, At least a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; 1 type may be substituted); phenyl C1-6 alkoxy group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group) At least one group selected from the group consisting of: a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted); a naphthyl C1-6 alkyl group and a phenyl C1-6 alkylidene group (on the phenyl ring, a halogen atom, From the group consisting of halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups And at least one group selected from the group consisting of a group selected from the group consisting of: a group selected from the group consisting of: May be);
(D) Pyridyloxy group (on the pyridine ring, (d-1) piperidyl group [on the piperidine ring, a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group And at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted), phenyl C1-6 alkoxy-substituted C1-6 alkyl groups (on the phenyl ring) , At least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), phenoxy C1 -6 alkyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C -6 at least one group selected from the group consisting of alkoxy groups may be substituted, and a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of an alkyl group and a group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted). And (d-2) a piperazinyl group [on the piperazine ring a C1-6 alkoxycarbonyl group, a furyl C1-6 alkyl group (on the furan ring, at least one phenyl group [on the phenyl ring] Is a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group 1 type may be substituted], a pyridyl C1-6 alkyl group (on the pyridine ring, a furyl group and a phenyl group [on the phenyl ring, a halogen atom, halogen substitution or At least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] at least of a group selected from the group consisting of 1 type may be substituted), a benzothienyl C1-6 alkyl group (on the benzothiophene ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of alkoxy groups may be substituted), a phenyl C2-6 alkenyl group (on the phenyl ring, a halogen atom, a halogen atom). At least one selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), a benzofuryl C1-6 alkyl group ( On the benzofuran ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. Benzofuryl C2-6 alkenyl group (on the benzofuran ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one of which may be substituted), a thiazolyl C 1-6 alkyl group (on the thiazole ring, at least one phenyl Group [on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. May be substituted), a phenoxy C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of alkoxy groups may be substituted), an indolyl C1-6 alkyl group (on the indole ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group) And at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted) and phenyl C1-6a Kill group (on the phenyl ring, at least one selected from the group consisting of benzofuryl group, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group) And at least one group selected from the group consisting of: a group selected from the group consisting of: may be substituted) may be substituted);
(E) 1,2,3,4-tetrahydroquinolyloxy group (an oxo group on the 1,2,3,4-tetrahydroquinoline ring, a phenyl group [on the phenyl ring, a halogen atom, halogen substitution or At least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] and a phenyl C1-6 alkyl group [phenyl ring Above, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] At least one group selected from the group consisting of may be substituted);
(F) 1,2,3,4-tetrahydronaphthyloxy group (at least one oxo group may be substituted on the 1,2,3,4-tetrahydronaphthalene ring);
(G) 2H-chromenyloxyl group (at least one oxo group may be substituted on the 2H-chromene ring);
(H) a naphthyloxy group (at least one piperidyl group on the naphthalene ring [at least one phenoxy group on the piperidine ring (halogen atom, halogen-substituted or unsubstituted C 1- A group selected from the group consisting of a 6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) may be substituted]. );
(I) 1,2,3,4-tetrahydroisoquinolyloxy group (on 1,2,3,4-tetrahydroisoquinoline ring, C1-6 alkoxycarbonyl group, phenyl C1-6 alkyl group [on phenyl ring May be substituted with at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] and Phenyl group [on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. And at least one group selected from the group consisting of may be substituted);
(J) Group —NR ²² R ²³
(R ²² represents a hydrogen atom or a C 1-6 alkyl group. R ²³ represents (j-1) phenyl group [on the phenyl ring, at least one piperidyl group (on the piperidine ring, at least one A phenoxy group [on the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. May be substituted)], (j-2) phenyl C1-6 alkyl group [on the phenyl ring, piperidyl group (on the piperidine ring) A phenoxy group [on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is placed. May be substituted] and a group —NR ²⁴ R ²⁵ (R ²⁴ represents a hydrogen atom or a C 1-6 alkyl group. R ²⁵ represents a phenyl C 2-6 alkenyl group [ On the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. It is assumed that at least one group selected from the group consisting of: is substituted], (j-3) piperidyl C1-6 alkyl group [on the piperidine ring, at least one group selected from A phenyl group (on the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted; Have And (j-4) a thiazolyl group [on the thiazole ring, a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group) At least one group selected from the group consisting of a group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), piperazinyl C1-6 alkyl group (on the piperazine ring, at least one group) Of the phenyl group [on the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. Optionally substituted] and piperidyl C1-6 alkyl groups (on the piperidine ring at least one phenoxy group [on the phenyl ring, halo Or a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]. Or at least one group selected from the group consisting of: may be substituted] or (j-5) phenyl C2-6 alkenyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted At least one group selected from the group consisting of a substituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]. );
(K) a benzoxazolyloxy group (on the benzoxazole ring, a piperazinyl group [on the piperazine ring, a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1 6 alkyl groups and at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted) and phenyl C2-6 alkenyl groups (on the phenyl ring, halogen At least one selected from the group consisting of an atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted). At least one of the selected groups may be substituted], a piperidyl group [on the piperidine ring, a phenyl C1-6 alkyl group (Fe On the ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. And a C1-6 alkyl group and a phenyl group on the amino group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 A group selected from the group consisting of 6 alkoxy groups may be substituted], a group selected from the group consisting of at least one group may be substituted) At least one may be substituted] and a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1 At least one group selected from the group consisting of 6 alkoxy group at least one group selected from the group consisting of and may have) substitution assumed to substituted);
(L) Benzimidazolyloxy group (on the benzimidazole ring, a C1-6 alkyl group, a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted group) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted], piperidyl group [at least one phenoxy group on the piperidine ring (halogen atom on the phenyl ring, A halogen-substituted or unsubstituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted). A piperazinyl group [on the piperazine ring at least one phenyl C1-6 alkyl group (on the phenyl ring a halogen atom, halo Or a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted). And a phenyl C1-6 alkyl group [on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] At least one of the groups selected from the group consisting of: which may be substituted] may be substituted);
(M) 1,2,3,4-tetrahydroisoquinolyl group (on the 1,2,3,4-tetrahydroisoquinoline ring, (m-1) amino group [C1-6 alkyl on amino group] A group, a phenyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; Optionally substituted) and a phenyl C1-6 alkyl group (on the phenyl ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one group selected from the group consisting of a group selected from the group consisting of: (m-2) a phenoxy group [on the phenyl ring] The halo A group selected from the group consisting of a gen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]. At least one of the selected groups may be substituted);
(N) a piperidyl group (on the piperidine ring, (n-1) a phenyl group [on the phenyl ring, at least one group —NR ²⁶ R ²⁷ (R ²⁶ represents a hydrogen atom or a C 1-6 alkyl group) R ²⁷ represents a phenyl group [on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C 1-6 alkyl group, and a halogen-substituted or unsubstituted C 1-6 alkoxy group; At least one may be substituted.]) Is substituted], (n-2) group -W ₁ NR ²⁸ R ²⁹ [W ₁ represents a C 1-6 alkylene group. R ²⁸ represents a hydrogen atom or a C 1-6 alkyl group, and R ²⁹ represents a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C 1-6 alkyl group, and a halogen-substituted or unsubstituted C 1 Of a group selected from the group consisting of ˜6 alkoxy groups At least one kind may be substituted)], (n-3) a C1-6 alkoxy group substituted with two phenyl groups [on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1 -6 alkyl group and at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] and (n-4) phenyl C1-6 alkyl group [phenyl On the base ring, at least one phenyl group (on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one of the groups selected from the group consisting of] may be substituted).
(O) Piperazinyl group (on the piperazine ring, a C1-6 alkyl group substituted with two phenyl groups [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or non-substituted group) At least one group selected from the group consisting of substituted C1-6 alkoxy groups may be substituted], phenyl C1-6 alkyl group [on the phenyl ring, at least one phenoxy group (phenyl ring) Above, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. ) Is substituted], thiazolyl group [at least one phenyl group may be substituted on the thiazole ring], Nonoxy C1-6 alkyl group [on phenyl ring, phenyl group (on phenyl ring, consisting of halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group Selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. At least one of the groups may be substituted], a phenyl C2-6 alkenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group] And at least one group selected from the group consisting of C1-6 alkoxy groups is substituted] and imidazo [On the imidazole ring, it comprises at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] And at least one group selected from the group may be substituted) and may be substituted]. At least one group selected from the group consisting of:
(P) thiazolyl C1-6 alkoxy group (on the thiazole ring, (p-1) phenoxy C1-6 alkyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen At least one group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted], (p-2) anilino C1-6 alkyl group [on the phenyl ring, halogen At least one selected from the group consisting of an atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted], (p-3 ) Phenyl C1-6 alkyl group [on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] At least one of the groups may be substituted], (p-4) piperazinyl C1-6 alkyl group [on the piperazine ring at least one phenyl group (on the phenyl ring, halogen atom, halogen A group selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted)] And (p-5) a piperidyl C1-6 alkyl group [on the piperidine ring at least one phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or At least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted) and may be substituted] at least one group selected from the group consisting of There may be substituted);
(q) 8-azabicyclo [3.2.1] octyl group (at least one phenoxy group on the 8-azabicyclo [3.2.1] octane ring [halogen atom, halogen substitution on the phenyl ring] Or at least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted].
(r) group

[Wherein X represents a halogen atom or an amino-substituted C1-6 alkyl group which may have a C1-6 alkyl group as a substituent. m shows the integer of 0-3. R ³ represents any one of the following groups (i) to (xxii).
(i) Group- (W) o-NR ⁴ R ⁵
(W is, .R ⁴ .o is indicating 0 or 1 indicating the group -CO- or C1~6 alkylene group, a hydrogen atom, a C1~6 alkyl group or a phenylcarbamoyl group [on the phenyl ring, a halogen atom , .R ⁵ showing a may be at least one substituted group selected from the group consisting of C1~6 alkoxy group a halogen substituted or unsubstituted C1~6 alkyl group and halogen-substituted or unsubstituted] is Phenyl C1-6 alkoxycarbonyl group [on the phenyl ring, at least a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; 1 type may be substituted]; phenyl C2-6 alkenylcarbonyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1- At least one group selected from the group consisting of 6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted]; phenyl C2-6 alkenyl groups [on the phenyl ring, halogen At least one selected from the group consisting of an atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]; piperidyl C1-6 An alkyl group [consisting of at least one phenyl group on the piperidine ring (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group A group selected from the group may be substituted); a phenyl C1-6 alkyl group [on the phenyl ring] Is a group selected from the group consisting of at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group). Benzofuryl C1-6 alkyl group [on the benzofuran ring, at least one halogen-substituted or unsubstituted C1-6 alkyl group is assumed to be substituted]. May be substituted]; piperidylcarbonyl C1-6 alkyl group [on the piperidine ring at least one phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and At least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted) It may also be] or group

[R ⁶ is, Cl to 6 alkyl groups; On phenyl group (the phenyl ring, C1 -4 alkylenedioxy group, a cyano group, a nitro group, an amino group which may have a Cl to 6 alkyl groups as substituents, An amino-substituted sulfonyl group that may have a C1-6 alkyl group as a substituent, a C1-6 alkoxycarbonyl group, a C1-6 alkylthio group, a phenoxy group, a phenyl C1-6 alkoxy group, a pyrrolidinyl group [on the pyrrolidine ring, At least one oxo group may be substituted], an imidazolyl group, an isoxazolyl group, an oxazolyl group, a phenyl C1-6 alkyl group, a phenyl group, an amino C1 to C1-6 alkyl group which may have a C1-6 alkyl group as a substituent 6 alkyl group, pyrrolidinyl C1-6 alkoxy group, halogen atom, halogen-substituted or unsubstituted C -6 alkyl group and at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted); phenyl C1-6 alkoxycarbonyl group (on the phenyl ring) , A halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted); 6 alkyl group (on the benzofuran ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. Benzofuryl C2-6 alkenyl group (on the benzofuran ring, halogen atom, halogen substitution) Or at least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted); a phenoxy C1-6 alkyl group (phenyl On the ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) A thiazolyl C1-6 alkyl group (on the thiazole ring, at least one phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of alkoxy groups may be substituted] may be substituted); -6 alkyl group (on the phenyl ring, from the group consisting of a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group A group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. At least one of them may be substituted); a pyridyl C1-6 alkyl group (on the pyridine ring, at least one phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1- A group selected from the group consisting of 6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted] C1-6 alkoxycarbonyl group; benzoyl group (on the phenyl ring, from halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group) And at least one group selected from the group may be substituted); a phenylcarbamoyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted); a benzothienyl group; a benzothienyl C1-6 alkyl group (on the benzothiophene ring at least one halogen); An indolyl C1-6 alkyl group (on the indole ring, the halogen atom may be substituted) 4H-1, at least one group selected from the group consisting of a group selected from the group consisting of a C 1-6 alkyl group and a halogen-substituted or unsubstituted C 1-6 alkyl group and a halogen-substituted or unsubstituted C 1-6 alkoxy group); 3-benzodioxinyl group (at least one halogen atom may be substituted on the 4H-1,3-benzodioxine ring); naphthyl group; quinolyl group; benzothiazolyl group (on benzothiazole ring) May be substituted with at least one C1-6 alkyl group); 2,3-dihydro-1H-indenyl group (on the 2,3-dihydro-1H-indane ring, at least one oxo Group may be substituted); 9H-fluorenyl group or phenyl C2-6 alkenyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group) And at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted. ]
Indicates. );
(ii) Group

(W and o are the same as described above. The dotted line may indicate a double bond. When the dotted line indicates a double bond, only R ⁸ is substituted. R ⁷ is a hydrogen atom, hydroxyl, [on the phenyl ring, halogen may be substituted] Cl to 6 alkoxy group or a phenyl group .R ⁸ showing a indicates one of the following groups (1) to (63).
(1) Phenyl C1-6 alkoxy substituted C1-6 alkyl group (on the phenyl ring, C1-4 alkylenedioxy group, halogen atom, cyano group, phenyl group, phenyl C1-6 alkoxy group, phenyl C2-6 alkenyl) At least one group selected from the group consisting of a group, a phenoxy group, a C1-6 alkylthio group, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. May be);
(2) Phenyl C1-6 alkoxy group (on the phenyl ring, cyano group, phenyl group, C1-6 alkoxycarbonyl group, phenoxy group, C1-6 alkylthio group, halogen atom, halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of an alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted);
(3) Phenyl C2-6 alkenyloxy group (on the phenyl ring, selected from the group consisting of halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups) At least one of the groups may be substituted);
(4) Group-(W) o-NR ⁹ R ¹⁰
(W and o are the same as above.
R ⁹ and R ¹⁰ are the same or different and are a hydrogen atom; a C 1-6 alkyl group which may have a hydroxyl group as a substituent; a C 1-6 alkanoyl group; a C 1-6 alkoxycarbonyl group; a phenyl C 1-6 alkoxycarbonyl group. [At least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted on the phenyl ring. A phenyl group [on the phenyl ring, a halogen atom as a substituent, a halogen-substituted or unsubstituted C1-6 alkyl group, a halogen-substituted or unsubstituted C1-6 alkoxy group, a C1-6 alkanoyl as a substituent] An amino group which may have a group selected from the group consisting of a group and a C1-6 alkyl group, a C1-6 alkoxycarbonyl group Phenyl group, phenoxy group (on the phenyl ring, at least one kind selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) May be substituted), an aminosulfonyl group, 1,2,3,4-tetrahydroquinolyl group (on the 1,2,3,4-tetrahydroquinoline ring, at least one oxo group as a substituent) Optionally substituted), C1-6 alkylsulfonyl group, C3-8 cycloalkyl group, nitro group, cyano group, C1-6 alkylthio group, phenylsulfonyl group (on the phenyl ring, halogen atom, halogen substituted or At least one selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. Group), hydroxyl-substituted C1-6 alkyl groups and groups

(W ₁ represents a C 1-6 alkylene group. R ¹¹ and R ¹² are the same or different and represent a C 1-6 alkoxy group) and at least one group selected from the group consisting of is substituted. Phenyl C1-6 alkyl group [on the phenyl ring, a C1-4 alkylenedioxy group as a substituent, a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl] A group selected from the group consisting of a group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), a group —N (R ^11A ) R ^12A (R ^11A and R ^12A are R ^11A and R ^12A are the same or different and each represents a hydrogen atom, a C 1-6 alkyl group or a phenyl group, and R ^11A and R ^12A are bonded together with or without a nitrogen atom, oxygen atom or sulfur atom together with an adjacent nitrogen atom. A 5- to 7-membered saturated heterocyclic ring), a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6) At least one group selected from the group consisting of alkoxy groups may be substituted), phenyl C1-6 alkoxy groups, amino group-substituted C1-6 alkoxys that may have C1-6 alkyl groups as substituents A group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-10 alkoxy group may be substituted]; benzofuryl C1-6 alkyl group [on the benzofuran ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1 At least one group selected from the group consisting of 6 alkoxy groups may be substituted]; phenylsulfonyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, halogen] At least one group selected from the group consisting of a substituted or unsubstituted C1-6 alkoxy group and a C1-4 alkylenedioxy group may be substituted]; a phenoxycarbonyl group [on the phenyl ring, a halogen At least one selected from the group consisting of an atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]; phenyl C2-6 Alkenyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of alkoxy groups may be substituted]; C1-6 alkoxy substituted C1-6 alkyl groups; C2-6 alkenyl groups; C1-6 alkoxy substituted C2-6 alkanoyl groups C3-8 cycloalkyl-substituted C1-6 alkyl group; phenoxy C1-6 alkyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6; At least one group selected from the group consisting of alkoxy groups may be substituted]; a benzoyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or At least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted]; phenylcarbamoy [On the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. A pyridyl group; a pyridyl C1-6 alkyl group; an imidazolyl C1-6 alkyl group; a 1,2,3,4-tetrahydroquinolyl group [1,2,3,4-tetrahydroquinoline ring; And at least one group selected from the group consisting of an oxo group and a C1-6 alkyl group may be substituted as a substituent]; a quinolyl group; an indolyl group; a C1-6 alkyl group as a substituent Indazolyl group; naphthyl group; C3-8 cycloalkyl group; amino substituted C1-6 alkyl which may have C1-6 alkyl group as a substituent Group; cyano-substituted C1~6 alkyl group; furyl substituted C1~6 alkyl group; group

[RR represents a phenyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. Species may be substituted). Or a piperazinyl-substituted C1-6 alkyl group [on the piperazine ring at least one phenyl group as a substituent (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or And at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted)].
R ⁹ and R ¹⁰ together with the adjacent nitrogen atom are bonded to each other through or without a nitrogen atom, an oxygen atom or a sulfur atom to form a 1,2,3,4-tetrahydroisoquinolyl group, an isoindolyl group or a 5- A 7-membered saturated heterocyclic ring may be formed. On the heterocyclic ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, a halogen-substituted or unsubstituted C1-6 alkoxy group, a phenyl group [on the phenyl ring, a phenyl group, a halogen atom, a halogen At least one group selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted], a benzoyl group [on the phenyl ring May be substituted with at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group], pyridyl C1-6 alkyl group, C3-8 cycloalkyl group, phenyl C1-6 alkyl group [on the phenyl ring, C1-4 alkylenedioxy group, halogen At least one selected from the group consisting of an atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted], piperidyl C1-6 Alkyl group, piperidyl group, phenyl C1-6 alkoxy group [on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] At least one of the selected groups may be substituted], a phenoxy group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy At least one group selected from the group consisting of groups may be substituted], a phenyl group as a substituent [on the phenyl ring, A group selected from the group consisting of a gen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] may be substituted], C1-6 An alkyl group and a phenyl C1-6 alkyl group [on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group; At least one of the groups selected from the group consisting of: an amino group, a benzoxazolyl group, a phenyl C2-6 alkenyl group (on the phenyl ring) Is a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group And at least one group selected from the group consisting of benzoimidazolyl groups may be substituted).
(5) a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1 A group selected from the group consisting of -6 alkoxy groups may be substituted), a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one group selected from the group may be substituted);
(6) Carbamoyloxy group (on the amino group, a C1-6 alkyl group and a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1 At least one group selected from the group consisting of ˜6 alkoxy groups may be substituted], at least one group selected from the group consisting of may be substituted);
(7) Carbamoyloxy-substituted C1-6 alkyl group (on the amino group, a C1-6 alkyl group, a phenyl C1-6 alkyl group, a C3-8 cycloalkyl group, a naphthyl group, 2,3-dihydro-1H-indenyl Group, 2,3-dihydrobenzofuryl group and phenyl group [on the phenyl ring, C1-4 alkylenedioxy group, cyano group, phenoxy group, C1-6 alkylthio group, C1-6 alkanoyl group, phenyl group, phenyl group Even if at least one group selected from the group consisting of a C1-6 alkyl group, a halogen atom, a halogen-substituted or unsubstituted C1-10 alkyl group and a halogen-substituted or unsubstituted C1-10 alkoxy group is substituted At least one group selected from the group consisting of:
(8) Phenoxy C1-6 alkyl group (on the phenyl ring, halogen atom; C1-4 alkylenedioxy group; C1-6 alkoxycarbonyl group; phenyl group; phenoxy group; pyrrolyl group; benzothiazolyl group; 1,2, 4-triazolyl group; imidazolyl group; isoxazolyl group; benzoxazolyl group; benzotriazolyl group; cyano group; nitro group; C2-6 alkanoyl group; C1-6 alkanoyl group; An alkyl group; a C1-6 alkanoyl-substituted C1-6 alkyl group; a group -N ( ^R11B ) ^R12B ( ^R11B and ^R12B may be the same or different and each represents a hydrogen atom, a C1-6 alkyl group, a C1-6 alkanoyl group, or .R ^11B and R ^12B represents a phenyl group, together with the adjacent nitrogen atom, via a nitrogen atom, an oxygen atom or a sulfur atom May form a 5- to 7-membered saturated heterocyclic ring without any intervening, on which a C1-6 alkoxycarbonyl group and an amino group [on the amino group, a phenyl group (phenyl On the ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. And at least one group selected from the group consisting of C1-6 alkyl groups may be substituted], at least one group selected from the group consisting of may be substituted); phenyl C1 -6 alkoxy group; phenyl C1-6 alkyl group; C1-6 alkylthio group; C3-8 cycloalkyl group; halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1~10 at least one group selected from the group consisting of alkoxy group which may be substituted);
(9) tetrahydropyranyloxy C1-6 alkyl group;
(10) hydroxyl group-substituted C1-6 alkyl group;
(11) Furyl C1-6 alkoxy-substituted C1-6 alkyl group (on the furan ring, at least one C1-6 alkoxycarbonyl group may be substituted);
(12) tetrazolyl C1-6 alkoxy-substituted C1-6 alkyl group (on the tetrazole ring, phenyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted), a phenyl C1-6 alkyl group and a C3-8 cycloalkyl C1-6 alkyl group. Group may be substituted);
(13) isoxazolyl C1-6 alkoxy-substituted C1-6 alkyl group (on the isoxazole ring, at least one C1-6 alkyl group may be substituted);
(14) A benzothienyl C1-6 alkoxy-substituted C1-6 alkyl group (on the benzothiophene ring, from a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one group selected from the group consisting of may be substituted);
(15) 1,3,4-oxadiazolyl C1-6 alkoxy-substituted C1-6 alkyl group (on the 1,3,4-oxadiazole ring, phenyl group [on the phenyl ring, halogen atom, halogen-substituted or At least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] may be substituted);
(16) a C2-6 alkynyloxy substituted C1-6 alkyl group;
(17) Naphthyl C1-6 alkoxy substituted C1-6 alkyl group;
(18) 1,2,4-oxadiazolyl C1-6 alkoxy-substituted C1-6 alkyl group [on the 1,2,4-oxadiazole ring, a phenyl group may be substituted];
(19) Pyridyl C1-6 alkoxy-substituted C1-6 alkyl group [on the pyridine ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one of the more selected groups may be substituted];
(20) thiazolyl C1-6 alkoxy-substituted C1-6 alkyl group [on thiazole ring, phenyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted And at least one group selected from the group consisting of C1-6 alkoxy groups may be substituted) and at least one group selected from the group consisting of C1-6 alkyl groups may be substituted. ];
(21) 1,2,3,4-tetrahydronaphthyl C1-6 alkoxy-substituted C1-6 alkyl group [the 1,2,3,4-tetrahydronaphthalene ring is substituted with at least one C1-6 alkyl group You may do it];
(22) Carbamoyl C1-6 alkoxy-substituted C1-6 alkyl group [on the amino group a C3-8 cycloalkyl group and a phenyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 alkyl And at least one group selected from the group consisting of a group selected from the group consisting of a group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) Good];
(23) A benzofuryl C1-6 alkoxy-substituted C1-6 alkyl group [on the benzofuran ring, at least one cyano group may be substituted];
(24) Benzofuryl C1-6 alkyl group [on the benzofuran ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one of them may be substituted];
(25) Phenoxy group [on the phenyl ring, at least one group selected from the group consisting of a phenyl C1-6 alkoxy group, a C3-8 cycloalkyl group, a C7-10 alkoxy group, and a phenoxy group is substituted. Shall be]];
(26) naphthyloxy group;
(27) 2,3-dihydrobenzofuryloxy group [at least one oxo group may be substituted on the 2,3-dihydrobenzofuran ring];
(28) benzothiazolyloxy group [on the benzothiazole ring, at least one C1-6 alkyl group may be substituted];
(29) 1,2,3,4-tetrahydronaphthyloxy group [at least one oxo group may be substituted on the 1,2,3,4-tetrahydronaphthalene ring];
(30) dibenzofuryloxy group;
(31) quinolyloxy group;
(32) Furyl C1-6 alkoxy group [on the furan ring, at least one C1-6 alkoxycarbonyl group may be substituted];
(33) tetrazolyl C1-6 alkoxy group [on the tetrazole ring, at least one group selected from the group consisting of a phenyl C1-6 alkyl group and a C3-8 cycloalkyl C1-6 alkyl group is substituted. Good];
(34) 1,2,4-oxadiazolyl C1-6 alkoxy group [on the 1,2,4-oxadiazole ring, a phenyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 A group selected from the group consisting of a 6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) may be substituted];
(35) benzothienyl C1-6 alkoxy group [on the benzothiophene ring, at least one halogen atom may be substituted];
(36) isoxazolyl C1-6 alkoxy group [at least one C1-6 alkyl group may be substituted on the isoxazole ring];
(37) 1,3,4-oxadiazolyl C1-6 alkoxy group [on the 1,3,4-oxadiazole ring, at least one phenyl group (on the phenyl ring, at least one C1-6 An alkyl group may be substituted) may be substituted];
(38) Naphthyl C1-6 alkoxy group;
(39) Pyridyl C1-6 alkoxy group (at least one halogen-substituted or unsubstituted C1-6 alkyl group may be substituted on the pyridine ring);
(40) thiazolyl C1-6 alkoxy group [on the thiazole ring, at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted) may be substituted];
(41) 1,2,3,4-tetrahydronaphthyl C1-6 alkoxy group (on the 1,2,3,4-tetrahydronaphthalene ring, at least one C1-6 alkyl group may be substituted) );
(42) a phenoxy C1-6 alkoxy group (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one of them may be substituted);
(43) Carbamoyl C1-6 alkoxy group [on the amino group, a C3-8 cycloalkyl group and a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or At least one group selected from the group consisting of a group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted];
(44) A benzofuryl C1-6 alkoxy group (on the benzofuran ring, at least one cyano group may be substituted);
(45) Naphtyloxy C1-6 alkyl group (on the naphthalene ring, at least one C1-6 alkoxy group may be substituted);
(46) benzothiazolyloxy C1-6 alkyl group (on the benzothiazole ring, at least one C1-6 alkyl group may be substituted);
(47) Quinolyloxy C1-6 alkyl group (on the quinoline ring, at least one C1-6 alkyl group may be substituted);
(48) 2,3-dihydrobenzofuryloxy C1-6 alkyl group (on the 2,3-dihydrobenzofuran ring, at least one group selected from the group consisting of a C1-6 alkyl group and an oxo group is substituted) You may)
(49) 1,2,3,4-tetrahydronaphthyloxy C1-6 alkyl group (on the 1,2,3,4-tetrahydronaphthalene ring, at least one oxo group may be substituted);
(50) 2,3-dihydro-1H-indenyloxy C1-6 alkyl group (at least one oxo group may be substituted on the 2,3-dihydro-1H-indene ring);
(51) a benzooxathiolanyloxy C1-6 alkyl group (on the benzooxathiolane ring, at least one oxo group may be substituted);
(52) Isoquinolyloxy C1-6 alkyl group;
(53) pyridyloxy C1-6 alkyl group;
(54) dibenzofuryloxy C1-6 alkyl group;
(55) 2H-1-benzopyranyloxy C1-6 alkyl group (on the 2H-1-benzopyran ring, at least one oxo group may be substituted);
(56) benzoisoxazolyloxy C1-6 alkyl group;
(57) Benzofurazanyloxy C1-6 alkyl group;
(58) Quinoxalyloxy C1-6 alkyl group;
(59) C1-6 alkoxy C1-6 alkoxy substituted C1-6 alkyl group;
(60) thienyl C1-6 alkoxy-substituted C1-6 alkyl group (on the thiophene ring, at least one halogen atom may be substituted);
(61) Phenyl C2-6 alkenyloxy-substituted C1-6 alkyl group (on the phenyl ring, consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one group selected from the group may be substituted);
(62) quinolyl C1-6 alkoxy substituted C1-6 alkyl group;
(63) piperidylcarbonyl C1-6 alkoxy substituted C1-6 alkyl group;
R ⁷ and R ⁸ may be taken together to form the group ═C (R ²⁹ ) (R ³⁰ ). Here, R ²⁹ and R ³⁰ are the same or different and each represents a hydrogen atom, a C1-6 alkyl group or a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or And at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted]. );
(iii) group

(W ₁ and o are the same as above. R ¹³ is 2,3-dihydro-1H-indenyl group; benzothienyl group; phenyl C 2-10 alkenyl group [on the phenyl ring, a halogen atom, C 1-4 alkylene diene] An oxy group, a C1-6 alkylthio group, a benzoyl group, a cyano group, a nitro group, a C2-6 alkanoyloxy group, an amino group that may have a C1-6 alkyl group as a substituent, a hydroxyl group, a phenyl C1-6 alkoxy group, At least one group selected from the group consisting of a phenoxy group, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]; 6 alkenyl group; benzofuryl C1-6 alkyl group [on the benzofuran ring, halogen atom, halogen-substituted or not At least one group selected from the group consisting of a C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]; a benzothienyl C2-6 alkenyl group; a benzothiazolyl C2- 6 alkenyl group [at least one C1-6 alkyl group may be substituted on the benzothiazole ring]; phenyl C1-6 alkyl group [on the phenyl ring, piperidinyl group (on the piperidine ring) At least one phenoxy group [on the phenyl ring, at least a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; May be substituted], a phenyl group (on the phenyl ring, a halogen atom, a halogen It is assumed that at least one group selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted, and a phenoxy group (on the phenyl ring) May be substituted with at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group). A diphenyl C1-6 alkyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen] At least one group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted]; C1-6 alkyl group [on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. May be substituted]; C1-6 alkyl group, C1-6 alkoxycarbonyl group and phenyl C1-6 alkyl group [on the phenyl ring, a phenyl group (on the phenyl ring, a halogen atom, halogen substitution or At least one group selected from the group consisting of unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted), halogen atoms, halogen-substituted or unsubstituted Less groups selected from the group consisting of C1-6 alkyl groups and halogen substituted or unsubstituted C1-6 alkoxy groups Or at least one group selected from the group consisting of: a C1-6 alkyl group and a phenyl group (on the phenyl ring, a halogen atom, A group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group (which may be substituted). An optionally substituted amino C1-6 alkyl group; a benzofuryl C2-6 alkenyl group [on the benzofuran ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group; At least one group selected from the group consisting of substituted C1-6 alkoxy groups may be substituted]; a piperidyl group [on the piperidine ring; , At least one phenyl C2-6 alkenyl group (on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group). A ferrocene-substituted C1-6 alkyl group, an indolyl C1-6 alkyl group (on the indole ring, at least one halogen atom may be substituted). May be substituted); phenyl C2-6 alkynyl group; phenyl group [on the phenyl ring, a C1-4 alkylenedioxy group, a phenyl group, a C1-6 alkoxycarbonyl group, a hydroxyl group and a phenoxy group (phenyl ring) Above, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of an alkoxy group may be substituted); a benzofuryl group [on the benzofuran ring] May be substituted with at least one group selected from the group consisting of a halogen atom and a C1-6 alkyl group]; a benzothiazolinyl group [at least one oxo on the benzothiazoline ring; A benzothienyl group [at least one halogen atom may be substituted on the benzothiophene ring]; a naphthyl group; 1,2,3,4-tetrahydroquinolyl Group [on the 1,2,3,4-tetrahydroquinoline ring, at least one group selected from the group consisting of an oxo group and a C1-6 alkyl group may be substituted]; 2,3-dihydrobenzofuryl group; 1,2-dihydrohydroquinolyl group [at least one oxo group may be substituted on the 1,2-dihydroquinoline ring] A 1,2,3,4-tetrahydroquinazolinyl group [on the 1,2,3,4-tetrahydroquinazoline ring, at least one group selected from the group consisting of an oxo group and a C1-6 alkyl group; May be substituted]; benzocycloheptyl group; phenoxy C1-6 alkyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of 6 alkoxy groups may be substituted]; a benzothienyl-substituted C1-6 alkyl group [on the benzothiophene ring; May have at least one halogen atom]; a naphthyl-substituted C1-6 alkyl group [at least one C1-6 alkoxy group may be substituted on the naphthalene ring]; pyridyl-substituted A C1-6 alkyl group [at least one halogen atom may be substituted on the pyridine ring]; a furyl-substituted C1-6 alkyl group [at least one nitro group is substituted on the furan ring. A thienyl substituted C1-6 alkyl group [on the thiophene ring may be substituted with at least one halogen atom]; a thiazolyl substituted C1-6 alkyl group [on the thiazole ring, C1 ~ 6 alkyl groups and phenyl groups (on the phenyl ring, at least a group selected from the group consisting of halogen atoms and halogen-substituted or unsubstituted C1-6 alkyl groups) At least one of the groups selected from the group consisting of 1 may be substituted); a tetrazolyl-substituted C1-6 alkyl group [on the tetrazole ring, at least one C1 -6 alkyl group may be substituted]; isoxazolyl-substituted C1-6 alkyl group [on the isoxazole ring, at least one C1-6 alkyl group may be substituted]; 4-Oxadiazolyl-substituted C1-6 alkyl group [At least one phenyl group on the 1,2,4-oxadiazole ring (C1-6 alkyl group may be substituted on the phenyl ring) ) May be substituted] or a benzofurazanyl-substituted C1-6 alkyl group. );
(iv) Group

(R ¹⁴ is a phenylamino group [wherein the N-position of the phenylamino group may be substituted with a C1-6 alkyl group, and on the phenyl ring of the phenylamino group, at least one halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]; piperidyl group [phenoxy group on the piperidine ring (halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted on the phenyl ring. ) And an amino group (on the amino group, a C1-6 alkyl group and a phenyl group as a substituent [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted group) And at least one group selected from the group consisting of C1-6 alkoxy groups may be substituted]. And at least one group selected from the group consisting of: a piperazinyl group [on the piperazine ring, a C1-6 alkoxycarbonyl group, a phenyl C1-6 alkyl group ( On the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. A phenyl C2-6 alkenyl group (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one of them may be substituted) and a benzoyl group (on the phenyl ring, a halogen atom, halogen-substituted or At least one group selected from the group consisting of a substituted C1-6 alkyl group and a group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups). A seed may be substituted]; a phenyl group (on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) A homopiperazinyl group [on the homopiperazine ring, a C1-6 alkoxycarbonyl group and a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen atom] A group selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one group selected from the group consisting of optionally substituted) or a phenoxy group [on the phenyl ring, halogen-substituted or unsubstituted C1-6. At least one group selected from the group consisting of an alkoxy group and a phenoxy-substituted phenyl group (at least one halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted on the phenyl ring); It may be substituted]. );
(v) Base

(R ¹³ is the same as above. The dotted line indicates that it may be a double bond.);
(vi) Homopiperazinyl group (C1-6 alkoxycarbonyl group on homopiperazine ring; phenyl C1-6 alkyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted) Alternatively, at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted]; a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1- At least one group selected from the group consisting of 6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted]; a phenyl C1-6 alkoxycarbonyl group [on the phenyl ring, Halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 atoms At least one group selected from the group consisting of alkoxy groups may be substituted]; phenylcarbamoyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted group] Or at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted]; phenyl C2-6 alkenyl groups [on the phenyl ring, halogen atoms, halogen substituted or unsubstituted At least one group selected from the group consisting of a substituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] and a benzoyl group [on the phenyl ring, From atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups That at least one group of at least one kind selected from the group consisting of] may be substituted groups may be substituted selected from a group);
(vii) group

(Wherein, R ¹⁹ is .R ²⁰ showing a C1~6 alkoxy group, on the phenyl group [the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1~6 alkyl group and halogen-substituted or unsubstituted And at least one group selected from the group consisting of C1-6 alkoxy groups may be substituted].
(viii) group —CHR ²⁰ R ²¹
(R ²⁰ is the same as described above. R ²¹ represents an amino group which may have a C1-6 alkyl group as a substituent.);
(ix) 1,2,3,4-tetrahydroisoquinolyl group (at least one amino group on the 1,2,3,4-tetrahydroisoquinoline ring [phenyl C1-6 alkyl on the amino group) Group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. And at least one group selected from the group consisting of C1-6 alkyl groups may be substituted] may be substituted);
(x) an oxazolyl group (on the oxazole ring, a phenyl group [on the phenyl ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one of the selected groups may be substituted], a C1-6 alkyl group and a piperidyl group [on the piperidine ring at least one phenoxy group (on the phenyl ring, a halogen atom, a halogen At least one group selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted but may be substituted). At least one group selected from the group of which may be substituted] may be substituted);
(xi) Isoindolinyl group (on the isoindoline ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group) May be substituted);
(xii) thiazolyl group (phenoxy C1-6 alkyl group on thiazole ring [halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group on phenyl ring) At least one group selected from the group consisting of may be substituted]; a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group; At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted]; phenyl C1-6 alkyl group [on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6; At least one selected from the group consisting of an alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted May be]; group ^{_{- (W 1) oNR 31 R}} 32 [W 1 and o are as defined above .R ³¹ and R ³² are the same or different, a hydrogen atom, Cl to 6 alkyl group, a phenyl group (On the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. Or a phenyl C1-6 alkyl group (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) A piperazinyl group [on the piperazine ring at least one phenyl group (on the phenyl ring, a halogen atom, A group selected from the group consisting of a rogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted)] A piperidyl group [on the piperidine ring is selected from the group consisting of a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; And at least one group selected from the group consisting of phenyl C1-6 alkyl groups may be substituted] and a phenoxy group [on the phenyl ring, From the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one selected from the group consisting of: at least one selected group may be substituted] may be substituted);
(xiii) a hydroxyl group-substituted C1-6 alkyl group;
(xiv) oxazolyl C1-6 alkyl group (on the oxazole ring, at least one phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted] may be substituted);
(xv) isoxazolyl group (on the isoxazoline ring, at least one phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 An at least one group selected from the group consisting of alkoxy groups may be substituted] may be substituted);
(xvi) a benzoxazolyl group (at least one halogen atom may be substituted on the benzoxazole ring);
(xvii) phenylthio group (on the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) May be substituted);
(xviii) a benzimidazolyl group (on the benzimidazole ring, a halogen atom and a phenyl C1-6 alkyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted group) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted], at least one group selected from the group consisting of C1-6 alkoxy groups may be substituted);
(xiv) a pyrrolidinyl group (at least one amino group on the pyrrolidine ring [C1-6 alkyl group on the amino group and a phenyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1 At least one group selected from the group consisting of -6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted). May be substituted));
(xx) phenylsulfonyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) Species may be substituted);
(xxi) an imidazolyl group (on the imidazole ring, at least one phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy And at least one group selected from the group consisting of groups may be substituted].
(xxii) a phenylsulfinyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) Species may be substituted);

(S) an imidazolyl group (on the imidazole ring, at least one group selected from the group consisting of a halogen atom and a nitro group may be substituted);
(T) an isoindolinyloxy group (on the isoindoline ring, a C1-6 alkoxycarbonyl group, a phenyl C1-6 alkyl group [on the phenyl ring, a benzofuryl group, a halogen atom, a halogen-substituted or unsubstituted C1- At least one group selected from the group consisting of 6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted], phenyl C2-6 alkenyl groups [on the phenyl ring, halogen At least one selected from the group consisting of an atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted], furyl C1-6 An alkyl group [on the furan ring, at least one phenyl group (on the phenyl ring, a halogen atom, Or at least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted.] A pyridyl C1-6 alkyl group [on the pyridine ring, a furyl group and a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of a group selected from the group consisting of alkoxy groups may be substituted), a benzofuryl C1-6 alkyl group [ On the benzofuran ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one group selected from the group described above may be substituted], a benzothienyl C1-6 alkyl group [on the benzothiophene ring may be substituted at least one halogen atom], A benzofuryl C2-6 alkenyl group [on the benzofuran ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; A seed may be substituted], a thiazolyl group [on the thiazole ring, at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or At least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted) May be selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. And at least one group selected from the group consisting of: may be substituted);
(U) a benzothiazolidinyloxy group (on the benzothiazolidine ring, an oxo group and a phenyl C1-6 alkyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen At least one group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted], and at least one group selected from the group consisting of may be substituted) ;
(V) Indolyloxy group (on the indole ring, at least one phenyl C1-6 alkyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or At least one group selected from the group consisting of substituted C1-6 alkoxy groups may be substituted] may be substituted);
(W) a pyrrolidinyl group (at least one amino group on the pyrrolidine ring [a C1-6 alkyl group on the amino group and a phenyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1 At least one group selected from the group consisting of -6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted). May be substituted));
(X) an indolinyl group (at least one halogen atom may be substituted on the indoline ring);
(Y) Indolinyloxy group (phenyl C1-6 alkyl group on indoline ring [halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 on phenyl ring) At least one group selected from the group consisting of alkoxy groups may be substituted] and at least one group selected from the group consisting of oxo groups may be substituted);

R ¹ and — (CH ₂ ) _n R ² are bonded to each other together with adjacent carbon atoms.

(Wherein RRR is a piperidyl group [on the piperidine ring, at least one phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group) And at least one group selected from the group consisting of C1-6 alkoxy groups may be substituted)] may be substituted].
A spiro ring represented by ]
2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compounds represented by the formula, optically active isomers thereof or pharmacologically acceptable salts thereof.
2. The 2,3-dihydro-6-nitro according to the above 1, wherein R ² is (a) to (c), (e) to (h), (j) to (q) or (s) to (y). An imidazo [2,1-b] oxazole compound, an optically active form thereof, or a pharmacologically acceptable salt thereof;
3. ^2. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 1 above, wherein R ² is (d), an optically active form thereof, or a pharmaceutically acceptable salt thereof.
4). ^2. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to the above 1, wherein R ² is (i), an optically active form thereof, or a pharmaceutically acceptable salt thereof.
5). ^2. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 1 above, wherein R ² is (r), an optically active form thereof, or a pharmaceutically acceptable salt thereof.
6). 2. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to the above 1, wherein R ¹ is a hydrogen atom, an optically active form thereof, or a pharmaceutically acceptable salt thereof.
7). 2. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to the above 1, wherein R ¹ is a C1-6 alkyl group, an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
8). R ¹ and — (CH ₂ ) _n R ² are bonded together with adjacent carbon atoms

(Wherein RRR is a piperidyl group [on the piperidine ring, at least one phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group) And at least one group selected from the group consisting of C1-6 alkoxy groups may be substituted)] may be substituted].
The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to the above 1, which forms a spiro ring represented by the following formula, an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
9. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (i), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
10. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (ii), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
11. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (iii), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
12 The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (iv), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
13. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (v), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
14 The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (vi), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
15. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (vii), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
16. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (viii), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
17. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (ix), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
18. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7, wherein R ³ is (x), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
19. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (xi), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
20. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (xii), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
21. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (xiii), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
22. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (xiv), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
23. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (xv), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
24. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (xvi), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
25. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (xvii), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
26. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7, wherein R ³ is (xviii), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
27. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7, wherein R ³ is (xix), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
28. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (xx), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
29. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (xxi), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
30. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to 6 or 7 above, wherein R ³ is (xxii), an optically active compound thereof, or a pharmacologically acceptable compound thereof salt.
31. The compound represented by the general formula (1)
2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylbenzyloxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole ,
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylbenzyloxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1 -B] oxazole,
(S) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylbenzyloxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1 -B] oxazole,
2-methyl-6-nitro-2- {4- [4- (4-chlorophenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -2-Methyl-6-nitro-2- {4- [4- (4-chlorophenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] Oxazole,
(S) -2-Methyl-6-nitro-2- {4- [4- (4-chlorophenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] Oxazole,
2-methyl-6-nitro-2- {4- [4- (4-trifluoromethylcinnamyl) piperazin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylcinnamyl) piperazin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1- b] oxazole,
(S) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylcinnamyl) piperazin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1- b] oxazole,
2-methyl-6-nitro-2- {4- [4- (4-trifluoromethoxycinnamyl) piperazin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethoxycinnamyl) piperazin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1- b] oxazole,
(S) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethoxycinnamyl) piperazin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1- b] oxazole,
2-methyl-6-nitro-2- {4- [4- (4-trifluoromethylphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole;
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1- b] oxazole,
(S) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1- b] oxazole,
6-nitro-2- {4- [4- (4-trifluoromethoxybenzyloxy) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -6-nitro-2- {4- [4- (4-trifluoromethoxybenzyloxy) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(S) -6-nitro-2- {4- [4- (4-trifluoromethoxybenzyloxy) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
6-nitro-2- {4- [4- (4-trifluoromethoxyphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -6-nitro-2- {4- [4- (4-trifluoromethoxyphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole;
(S) -6-nitro-2- {4- [4- (4-trifluoromethoxyphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole;
6-nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -6-nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(S) -6-nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
2-methyl-6-nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b ] Oxazole,
(S) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b ] Oxazole,
2-methyl-6-nitro-2- [4- {4- [4- (4-trifluoromethylphenyl) piperazin-1-yl] piperidin-1-yl} phenoxymethyl] -2,3-dihydroimidazo [ 2,1-b] oxazole,
(R) -2-Methyl-6-nitro-2- [4- {4- [4- (4-trifluoromethylphenyl) piperazin-1-yl] piperidin-1-yl} phenoxymethyl] -2,3 -Dihydroimidazo [2,1-b] oxazole,
(S) -2-Methyl-6-nitro-2- [4- {4- [4- (4-trifluoromethylphenyl) piperazin-1-yl] piperidin-1-yl} phenoxymethyl] -2,3 -Dihydroimidazo [2,1-b] oxazole,
2-Methyl-6-nitro-2- [4- {4- [4- (4-trifluoromethoxyphenoxy) benzyl] piperazin-1-yl} phenoxymethyl] -2,3-dihydroimidazo [2,1- b] oxazole,
(R) -2-Methyl-6-nitro-2- [4- {4- [4- (4-trifluoromethoxyphenoxy) benzyl] piperazin-1-yl} phenoxymethyl] -2,3-dihydroimidazo [ 2,1-b] oxazole,
(S) -2-Methyl-6-nitro-2- [4- {4- [4- (4-trifluoromethoxyphenoxy) benzyl] piperazin-1-yl} phenoxymethyl] -2,3-dihydroimidazo [ 2,1-b] oxazole,
6-nitro-2- [4- {4- [3- (4-trifluoromethoxyphenyl) propyl] piperidin-1-yl} phenoxymethyl] -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -6-nitro-2- [4- {4- [3- (4-trifluoromethoxyphenyl) propyl] piperidin-1-yl} phenoxymethyl] -2,3-dihydroimidazo [2,1- b] oxazole,
(S) -6-nitro-2- [4- {4- [3- (4-trifluoromethoxyphenyl) propyl] piperidin-1-yl} phenoxymethyl] -2,3-dihydroimidazo [2,1- b] oxazole,
2-methyl-6-nitro-2- {4- [2- (4-trifluoromethoxyphenyl) oxazol-4-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -2-Methyl-6-nitro-2- {4- [2- (4-trifluoromethoxyphenyl) oxazol-4-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b ] Oxazole,
(S) -2-Methyl-6-nitro-2- {4- [2- (4-trifluoromethoxyphenyl) oxazol-4-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b ] Oxazole,
6-nitro-2- {4- [4- (4-chlorophenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -6-nitro-2- {4- [4- (4-chlorophenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(S) -6-nitro-2- {4- [4- (4-chlorophenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
2-Methyl-6-nitro-2- {4- [4- (5-trifluoromethylbenzofuran-2-ylmethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b ] Oxazole,
(R) -2-Methyl-6-nitro-2- {4- [4- (5-trifluoromethylbenzofuran-2-ylmethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2 , 1-b] oxazole,
(S) -2-Methyl-6-nitro-2- {4- [4- (5-trifluoromethylbenzofuran-2-ylmethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2 , 1-b] oxazole,
2-methyl-6-nitro-2- {4- [2- (4-chlorophenyl) oxazol-4-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -2-methyl-6-nitro-2- {4- [2- (4-chlorophenyl) oxazol-4-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(S) -2-methyl-6-nitro-2- {4- [2- (4-chlorophenyl) oxazol-4-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
6-nitro-2- {4- [4- (4-trifluoromethylphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -6-nitro-2- {4- [4- (4-trifluoromethylphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole;
(S) -6-nitro-2- {4- [4- (4-trifluoromethylphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole;
2-methyl-6-nitro-2- {4- [4- (4-bromocinnamyl) piperazin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -2-methyl-6-nitro-2- {4- [4- (4-bromocinnamyl) piperazin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole;
(S) -2-methyl-6-nitro-2- {4- [4- (4-bromocinnamyl) piperazin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole;
2-Methyl-6-nitro-2- [2- (4-trifluoromethoxyphenyl) -1,2,3,4-tetrahydroisoquinolin-6-yloxymethyl] -2,3-dihydroimidazo [2,1 -B] oxazole,
(R) -2-Methyl-6-nitro-2- [2- (4-trifluoromethoxyphenyl) -1,2,3,4-tetrahydroisoquinolin-6-yloxymethyl] -2,3-dihydroimidazo [2,1-b] oxazole and (S) -2-methyl-6-nitro-2- [2- (4-trifluoromethoxyphenyl) -1,2,3,4-tetrahydroisoquinolin-6-yloxy 2. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to the above 1, which is selected from the group consisting of methyl] -2,3-dihydroimidazo [2,1-b] oxazole or a compound thereof Pharmacologically acceptable salt.

In the above general formula (1), R ¹ is preferably a hydrogen atom or a C 1-6 alkyl group. R ² is preferably (d), (i) or (r).

R ³ is preferably (ii), (iii) or (x).

R ⁸ is preferably (1), (2), (4), (5), (8), (24) or (25).

R ¹³ is a phenyl C2-10 alkenyl group [on the phenyl ring, a halogen atom, a C1-4 alkylenedioxy group, a C1-6 alkylthio group, a benzoyl group, a cyano group, a nitro group, a C2-6 alkanoyloxy group. An amino group which may have a C1-6 alkyl group as a substituent, a hydroxyl group, a phenyl C1-6 alkoxy group, a phenoxy group, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of alkoxy groups may be substituted] or a phenyl C1-6 alkyl group [on the phenyl ring, a piperidyl group (on the piperidine ring, at least one phenoxy group] Group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen A group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted], a phenyl group (on the phenyl ring, a halogen atom) , At least one group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted, and a phenoxy group (phenyl On the ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. And at least one group selected from the group consisting of:

In the present specification, each group represented by R ¹ , R ² , R ^{3 and the} like is specifically as follows.

  As a halogen atom, a fluorine atom, a chlorine atom, a bromine atom, and an iodine atom are shown.

  The C1-6 alkyl group is a linear or branched alkyl group composed of 1 to 6 carbon atoms, and examples thereof include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n- Examples thereof include a butyl group, an isobutyl group, a tert-butyl group, a sec-butyl group, an n-pentyl group, a neopentyl group, an n-hexyl group, an isohexyl group, and a 3-methylpentyl group.

  The C1-6 alkoxy group is a group composed of the C1-6 alkyl group defined above and an oxygen atom, for example, a methoxy group, an ethoxy group, an n-propoxy group, an isopropoxy group, an n-butoxy group. , Isobutoxy group, tert-butoxy group, sec-butoxy group, n-pentoxy group, neopentoxy group, n-hexyloxy group, isohexyloxy group, 3-methylpentoxy group and the like.

  The halogen-substituted or unsubstituted C1-6 alkyl group is a linear or branched alkyl group composed of 1 to 6 carbon atoms as defined above and the alkyl substituted with 1 to 7 halogen atoms. For example, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, sec-butyl, n-pentyl, neopentyl, n-hexyl Group, isohexyl group, 3-methylpentyl group, fluoromethyl group, difluoromethyl group, trifluoromethyl group, chloromethyl group, dichloromethyl group, trichloromethyl group, bromomethyl group, dibromomethyl group, dichlorofluoromethyl group, 2, 2,2-trifluoroethyl group, pentafluoroethyl group, 2-chloroethyl group, 3,3,3-to Fluoropropyl group, heptafluoropropyl group, heptafluoroisopropyl group, 3-chloropropyl group, 2-chloropropyl group, 3-bromopropyl group, 4,4,4-trifluorobutyl group, 4,4,4,3 , 3-pentafluorobutyl group, 4-chlorobutyl group, 4-bromobutyl group, 2-chlorobutyl group, 5,5,5-trifluoropentyl group, 5-chloropentyl group, 6,6,6-trifluorohexyl Group, 6-chlorohexyl group and the like.

  The halogen-substituted or unsubstituted C1-6 alkoxy group is a C1-6 alkoxy group defined above and the alkoxy group substituted with 1 to 7 halogen atoms, for example, a methoxy group, an ethoxy group, n-propoxy group, isopropoxy group, n-butoxy group, isobutoxy group, tert-butoxy group, sec-butoxy group, n-pentoxy group, neopentoxy group, n-hexyloxy group, isohexyloxy group, 3-methylpen Toxi group, fluoromethoxy group, difluoromethoxy group, trifluoromethoxy group, chloromethoxy group, dichloromethoxy group, trichloromethoxy group, bromomethoxy group, dibromomethoxy group, dichlorofluoromethoxy group, 2,2,2-trifluoroethoxy Group, pentafluoroethoxy group, 2-chloroethate Si group, 3,3,3-trifluoropropoxy group, heptafluoropropoxy group, heptafluoroisopropoxy group, 3-chloropropoxy group, 2-chloropropoxy group, 3-bromopropoxy group, 4,4,4-tri Fluorobutoxy group, 4,4,4,3,3-pentafluorobutoxy group, 4-chlorobutoxy group, 4-bromobutoxy group, 2-chlorobutoxy group, 5,5,5-trifluoropentoxy group, 5 -A chloropentoxy group, 6,6,6-trifluorohexyloxy group, 6-chlorohexyloxy group, etc. can be mentioned.

  A phenoxy group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. May be, for example, phenoxy group, 2-fluorophenoxy group, 3-fluorophenoxy group, 4-fluorophenoxy group, 2-chlorophenoxy group, 3-chlorophenoxy group, 4-chlorophenoxy group, 2 -Bromophenoxy group, 3-bromophenoxy group, 4-bromophenoxy group, 2,3-dichlorophenoxy group, 3,4-dichlorophenoxy group, 2,4-dichlorophenoxy group, 3,4,5-trichlorophenoxy group 2,4,6-trichlorophenoxy group, 2,3,4,5,6-pentafluorophenoxy 2-methylphenoxy group, 3-methylphenoxy group, 4-methylphenoxy group, 2-ethylphenoxy group, 3-ethylciphenoxy group, 4-ethylphenoxy group, 4-n-propylphenoxy group, 4-tert- Butylphenoxy group, 4-n-butylphenoxy group, 2-trifluoromethylphenoxy group, 3-trifluoromethylphenoxy group, 4-trifluoromethylphenoxy group, 2-pentafluoroethylphenoxy group, 3-pentafluoroethylphenoxy Group, 2,3-dimethylphenoxy group, 3,4,5-trimethylphenoxy group, 4-n-pentylphenoxy group, 4-n-hexylphenoxy group, 2-methoxyphenoxy group, 3-methoxyphenoxy group, 4- Methoxyphenoxy group, 2-ethoxyphenoxy group, 3-ethoxy Phenoxy group, 4-ethoxyphenoxy group, 4-n-propoxyphenoxy group, 4-tert-butoxyphenoxy group, 4-n-butoxyphenoxy group, 2-trifluoromethoxyphenoxy group, 3-trifluoromethoxyphenoxy group, 4 -Trifluoromethoxyphenoxy group, 2-pentafluoroethoxyphenoxy group, 3-pentafluoroethoxyphenoxy group, 2,3-dimethoxyphenoxy group, 3,4,5-trimethoxyphenoxy group, 4-n-pentyloxyphenoxy group A phenoxy group such as 4-n-hexyloxyphenoxy group (on the phenyl ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group) 1 to 5 selected groups, preferably 1 to 3 may be substituted).

  Piperidyl group [consisting of at least one phenoxy group on the piperidine ring (halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring) The group may be substituted with at least one group selected from the group] may be substituted, for example, 1-piperidyl group, 4-piperidyl group, 2-piperidyl group, 3-piperidyl group 4-phenoxy-1-piperidyl group, 2,4-diphenoxy-1-piperidyl group, 2,4,6-triphenoxy-1-piperidyl group, 2- (2-fluorophenoxy) -1-piperidyl group, 3 -(3-fluorophenoxy) -2-piperidyl group, 4- (4-fluorophenoxy) -3-piperidyl group, 2- (2-chlorophenoxy) -4-pi Lysyl group, 3- (3-chlorophenoxy) -5-piperidyl group, 4- (4-chlorophenoxy) -2-piperidyl group, 5- (2-bromophenoxy) -2-piperidyl group, 6- (3- Bromophenoxy) -3-piperidyl group, 4- (4-bromophenoxy) -1-piperidyl group, 3- (2,3-dichlorophenoxy) -2-piperidyl group, 4- (3,4-dichlorophenoxy)- 3-piperidyl group, 3- (2,4-dichlorophenoxy) -4-piperidyl group, 2- (3,4,5-trichlorophenoxy) -3-piperidyl group, 6- (2,4,6-trichlorophenoxy) ) -2-piperidyl group, 3- (2,3,4,5,6-pentafluorophenoxy) -1-piperidyl group, 4- (2-methylphenoxy) -1-piperidyl group, 5- (3-me Ruphenoxy) -2-piperidyl group, 6- (4-methylphenoxy) -3-piperidyl group, 1- (2-ethylphenoxy) -4-piperidyl group, 2- (3-ethylciphenoxy) -1-piperidyl group Group, 3- (4-ethylphenoxy) -2-piperidyl group, 4- (4-n-propylphenoxy) -3-piperidyl group, 3- (4-tert-butylphenoxy) -4-piperidyl group, 2- (4-n-butylphenoxy) -3-piperidyl group, 1- (2-trifluoromethylphenoxy) -2-piperidyl group, 2- (3-trifluoromethylphenoxy) -1-piperidyl group, 3- (4 -Trifluoromethylphenoxy) -1-piperidyl group, 1- (2-pentafluoroethylphenoxy) -4-piperidyl group, 1- (3-pentafluoroethylphenyl) Enoxy) -4-piperidyl group, 4- (2,3-dimethylphenoxy) -1-piperidyl group, 1- (3,4,5-trimethylphenoxy) -4-piperidyl group, 1- (4-n-pentyl) Phenoxy) -4-piperidyl group, 4- (4-n-hexylphenoxy) -1-piperidyl group, 4- (2-methoxyphenoxy) -1-piperidyl group, 1- (3-methoxyphenoxy) -4-piperidyl group Group, 1- (4-methoxyphenoxy) -4-piperidyl group, 2- (2-ethoxyphenoxy) -3-piperidyl group, 3- (3-ethoxyphenoxy) -4-piperidyl group, 4- (4-ethoxy Phenoxy) -3-piperidyl group, 3- (4-n-propoxyphenoxy) -2-piperidyl group, 2- (4-tert-butoxyphenoxy) -1-piperidyl group 1- (4-n-butoxyphenoxy) -2-piperidyl group, 2- (2-trifluoromethoxyphenoxy) -3-piperidyl group, 3- (3-trifluoromethoxyphenoxy) -4-piperidyl group, 4- (4-trifluoromethoxyphenoxy) -3-piperidyl group, 3- (2-pentafluoroethoxyphenoxy) -2-piperidyl group, 2- (4-pentafluoroethoxyphenoxy) -1-piperidyl group, 1- (2 , 3-dimethoxyphenoxy) -4-piperidyl group, 4- (3,4,5-trimethoxyphenoxy) -1-piperidyl group, 4- (4-n-pentyloxyphenoxy) -1-piperidyl group, 4- Piperidyl groups such as (4-n-hexyloxyphenoxy) -1-piperidyl group [on the piperidine ring, 1 to 3 phenoxy groups On the phenyl ring, there are 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group, preferably 1 to 3 may be substituted) may be substituted].

  A phenyl group (on the phenyl ring, at least one piperidyl group [on the piperidine ring, at least one phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and That at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted) may be substituted] For example, phenyl group, 4- (1-piperidyl) phenyl group, 2,4-di (1-piperidyl) phenyl group, 2,4,6-tri (1-piperidyl) phenyl group, 3- (4-piperidyl) Phenyl group, 2- (2-piperidyl) phenyl group, 4- (3-piperidyl) phenyl group, 3- (4-phenoxy-1-piperidyl) phenyl group, 2- (2,4-diphenoxy-1) Piperidyl) phenyl group, 4- (2,4,6-triphenoxy-1-piperidyl) phenyl group, 3- [2- (2-fluorophenoxy) -1-piperidyl] phenyl group, 2- [3- (3 -Fluorophenoxy) -2-piperidyl] phenyl group, 4- [4- (4-fluorophenoxy) -3-piperidyl] phenyl group, 3- [2- (2-chlorophenoxy) -4-piperidyl] phenyl group, 2- [3- (3-chlorophenoxy) -5-piperidyl] phenyl group, 4- [4- (4-chlorophenoxy) -2-piperidyl] phenyl group, 3- [5- (2-bromophenoxy)- 2-piperidyl] phenyl group, 2- [6- (3-bromophenoxy) -3-piperidyl] phenyl group, 4- [4- (4-bromophenoxy) -1-piperidyl] phenyl , 3- [3- (2,3-dichlorophenoxy) -2-piperidyl] phenyl group, 2- [4- (3,4-dichlorophenoxy) -3-piperidyl] phenyl group, 4- [3- (2 , 4-Dichlorophenoxy) -4-piperidyl] phenyl group, 3- [2- (3,4,5-trichlorophenoxy) -3-piperidyl] phenyl group, 2- [6- (2,4,6-trichloro Phenoxy) -2-piperidyl] phenyl group, 4- [3- (2,3,4,5,6-pentafluorophenoxy) -1-piperidyl] phenyl group, 3- [4- (2-methylphenoxy)- 1-piperidyl] phenyl group, 2- [5- (3-methylphenoxy) -2-piperidyl] phenyl group, 4- [6- (4-methylphenoxy) -3-piperidyl] phenyl group, 3- [1- (2-ethyl Phenoxy) -4-piperidyl] phenyl group, 2- [2- (3-ethylphenoxy) -1-piperidyl] phenyl group, 4- [3- (4-ethylphenoxy) -2-piperidyl] phenyl group, 3- [4- (4-n-propylphenoxy) -3-piperidyl] phenyl group, 2- [3- (4-tert-butylphenoxy) -4-piperidyl] phenyl group, 4- [2- (4-n- Butylphenoxy) -3-piperidyl] phenyl group, 3- [1- (2-trifluoromethylphenoxy) -2-piperidyl] phenyl group, 2- [2- (3-trifluoromethylphenoxy) -1-piperidyl] Phenyl group, 4- [3- (4-trifluoromethylphenoxy) -1-piperidyl] phenyl group, 3- [1- (2-pentafluoroethylphenoxy) -4-pi Lysyl] phenyl group, 2- [1- (3-pentafluoroethylphenoxy) -4-piperidyl] phenyl group, 4- [4- (2,3-dimethylphenoxy) -1-piperidyl] phenyl group, 3- [ 1- (3,4,5-trimethylphenoxy) -4-piperidyl] phenyl group, 2- [1- (4-n-pentylphenoxy) -4-piperidyl] phenyl group, 4- [4- (4-n -Hexylphenoxy) -1-piperidyl] phenyl group, 3- [4- (2-methoxyphenoxy) -1-piperidyl] phenyl group, 2- [1- (3-methoxyphenoxy) -4-piperidyl] phenyl group, 4- [1- (4-methoxyphenoxy) -4-piperidyl] phenyl group, 3- [2- (2-ethoxyphenoxy) -3-piperidyl] phenyl group, 2- [3- (3- Toxiphenoxy) -4-piperidyl] phenyl group, 4- [4- (4-ethoxyphenoxy) -3-piperidyl] phenyl group, 3- [3- (4-n-propoxyphenoxy) -2-piperidyl] phenyl group 2- [2- (4-tert-butoxyphenoxy) -1-piperidyl] phenyl group, 4- [1- (4-n-butoxyphenoxy) -2-piperidyl] phenyl group, 3- [2- (2 -Trifluoromethoxyphenoxy) -3-piperidyl] phenyl group, 2- [3- (3-trifluoromethoxyphenoxy) -4-piperidyl] phenyl group, 4- [4- (4-trifluoromethoxyphenoxy) -1 -Piperidyl] phenyl group, 3- [3- (2-pentafluoroethoxyphenoxy) -2-piperidyl] phenyl group, 2- [2- (4-pen Tafluoroethoxyphenoxy) -1-piperidyl] phenyl group, 4- [1- (2,3-dimethoxyphenoxy) -4-piperidyl] phenyl group, 3- [4- (3,4,5-trimethoxyphenoxy) -1-piperidyl] phenyl group, 2- [4- (4-n-pentyloxyphenoxy) -1-piperidyl] phenyl group, 4- [4- (4-n-hexyloxyphenoxy) -1-piperidyl] phenyl A phenyl group such as a group (1 to 3 piperidyl groups on the phenyl ring [1 to 3 phenoxy groups on the piperidine ring (halogen atom, halogen-substituted or unsubstituted C1 1 to 5 groups, preferably 1 to 3 groups selected from the group consisting of -6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups are substituted. There may be] it can be mentioned may) be substituted.

  Phenyl group [on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. May be selected from the group consisting of an unsubstituted phenyl group and a halogen atom as defined above, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. A phenyl group having 1 to 5, preferably 1 to 3 substituents, such as a phenyl group, a 2-fluorophenyl group, a 3-fluorophenyl group, a 4-fluorophenyl group, a 2-chlorophenyl group, 3-chlorophenyl group, 4-chlorophenyl group, 2-bromophenyl group, 3-bromophenyl group, 4-bromophenyl group, 2- Group, 3-iodophenyl group, 4-iodophenyl group, 2,3-difluorophenyl group, 3,4-difluorophenyl group, 3,5-difluorophenyl group, 2,4-difluorophenyl group, 2,6 -Difluorophenyl group, 2,3-dichlorophenyl group, 3,4-dichlorophenyl group, 3,5-dichlorophenyl group, 2,4-dichlorophenyl group, 2,6-dichlorophenyl group, 3,4,5-trifluorophenyl group 3,4,5-trichlorophenyl group, 2,4,6-trifluorophenyl group, 2,4,6-trichlorophenyl group, 2-fluoro-4-bromophenyl group, 4-chloro-3-fluorophenyl Group, 2,3,4-trichlorophenyl group, 2,3,4,5,6-pentafluorophenyl group, 2,4,6-trimethyl Enyl group, 4-n-butylphenyl group, 2,4-dimethylphenyl group, 2,3-dimethylphenyl group, 2,6-dimethylphenyl group, 3,5-dimethylphenyl group, 2,5-dimethylphenyl group 3,5-ditrifluoromethylphenyl group, 4-n-butoxyphenyl group, 2,4-dimethoxyphenyl group, 2,3-dimethoxyphenyl group, 2,6-dimethoxyphenyl group, 3,5-dimethoxyphenyl group 2,5-dimethoxyphenyl group, 2,4,6-trimethoxyphenyl group, 3,5-ditrifluoromethoxyphenyl group, 3-chloro-4-methoxyphenyl group, 2-chloro-4-trifluoromethoxyphenyl Group, 3-methyl-4-fluorophenyl group, 4-bromo-3-trifluoromethylphenyl group, 2-methylphenyl group, 3-methyl Tylphenyl group, 4-methylphenyl group, 2-methyl-3-chlorophenyl group, 3-methyl-4-chlorophenyl group, 2-chloro-4-methylphenyl group, 2-methyl-3-fluorophenyl group, 2-triphenyl Fluoromethylphenyl group, 3-trifluoromethylphenyl group, 4-trifluoromethylphenyl group, 2-pentafluoroethylphenyl group, 3-pentafluoroethylphenyl group, 4-pentafluoroethylphenyl group, 2-isopropylphenyl group 3-isopropylphenyl group, 4-isopropylphenyl group, 2-tert-butylphenyl group, 3-tert-butylphenyl group, 4-tert-butylphenyl group, 2-sec-butylphenyl group, 3-sec-butyl Phenyl group, 4-sec-butylphenyl group, 2-n-he Tafluoropropylphenyl group, 3-n-heptafluoropropylphenyl group, 4-n-heptafluoropropylphenyl group, 4-pentylphenyl group, 4-hexylphenyl group, 2-methoxyphenyl group, 3-methoxyphenyl group, 4-methoxyphenyl group, 3-chloro-2-methoxyphenyl group, 2-fluoro-3-methoxyphenyl group, 2-fluoro-4-methoxyphenyl group, 2,3,4-trifluorophenyl group, 2-triphenyl Fluoromethoxyphenyl group, 3-trifluoromethoxyphenyl group, 4-trifluoromethoxyphenyl group, 3-fluoro-2-trifluoromethoxyphenyl group, 2-fluoro-3-trifluoromethoxyphenyl group, 3-fluoro-4 -Trifluoromethoxyphenyl group, 3-chloro-2-trifluor Romethoxyphenyl group, 2-chloro-3-trifluoromethoxyphenyl group, 3-chloro-4-trifluoromethoxyphenyl group, 2-pentafluoroethoxyphenyl group, 3-pentafluoroethoxyphenyl group, 4-pentafluoroethoxy Phenyl group, 3-chloro-2-pentafluoroethoxyphenyl group, 2-chloro-3-pentafluoroethoxyphenyl group, 3-chloro-4-pentafluoroethoxyphenyl group, 2-isopropoxyphenyl group, 3-isopropoxy group Phenyl group, 4-isopropoxyphenyl group, 2-tert-butoxyphenyl group, 3-tert-butoxyphenyl group, 4-tert-butoxyphenyl group, 2-sec-butoxyphenyl group, 3-sec-butoxyphenyl group, 4-sec-butoxyphenyl Group, 2-n-heptafluoropropoxyphenyl group, 3-n-heptafluoropropoxyphenyl group, 4-n-heptafluoropropoxyphenyl group, 4-n-pentoxyphenyl group, 4-n-hexyloxyphenyl group, etc. Can be mentioned.

  Examples of the phenyl C1-6 alkyl group include a benzyl group, 1-phenethyl group, 2-phenethyl group, 3-phenylpropyl group, 2-phenylpropyl group, 4-phenylbutyl group, 5-phenylpentyl group, 4- A phenylpentyl group, 6-phenylhexyl group, 2-methyl-3-phenylpropyl group, 1,1-dimethyl-2-phenylethyl group and the like can be mentioned.

  A phenyl C1-6 alkyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; The seed may be substituted) means an unsubstituted phenyl C1-6 alkyl group and a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or phenyl group on the phenyl ring constituting the group. 1 to 5, preferably 1 to 3 groups selected from the group consisting of unsubstituted C1-6 alkoxy groups, such as benzyl, 1-phenethyl, 2-phenethyl Group, 3-phenylpropyl group, 2-phenylpropyl group, 4-phenylbutyl group, 5-phenylpentyl group, 4-phenylpentyl group, -Phenylhexyl group, 2-fluorobenzyl group, 3-fluorobenzyl group, 4-fluorobenzyl group, 2-chlorobenzyl group, 3-chlorobenzyl group, 4-chlorobenzyl group, 2-bromobenzyl group, 3-bromo Benzyl group, 4-bromobenzyl group, 2-iodobenzyl group, 3-iodobenzyl group, 4-iodobenzyl group, 2,3-difluorobenzyl group, 3,4-difluorobenzyl group, 3,5-difluorobenzyl group 2,4-difluorobenzyl group, 2,6-difluorobenzyl group, 2,3-dichlorobenzyl group, 3,4-dichlorobenzyl group, 3,5-dichlorobenzyl group, 2,4-dichlorobenzyl group, 2 , 6-dichlorobenzyl group, 2-fluoro-4-bromobenzyl group, 4-chloro-3-fluorobenzyl group, 2,3,4 Trichlorobenzyl group, 3,4,5-trifluorobenzyl group, 2,4,6-trichlorobenzyl group, 4-isopropylbenzyl group, 4-n-butylbenzyl group, 4-methylbenzyl group, 2-methylbenzyl group 3-methylbenzyl group, 2,4-dimethylbenzyl group, 2,3-dimethylbenzyl group, 2,6-dimethylbenzyl group, 3,5-dimethylbenzyl group, 2,5-dimethylbenzyl group, 2,4 , 6-trimethylbenzyl group, 3,5-ditrifluoromethylbenzyl group, 2,3,4,5,6-pentafluorobenzyl group, 4-isopropoxybenzyl group, 4-n-butoxybenzyl group, 4-methoxy Benzyl group, 2-methoxybenzyl group, 3-methoxybenzyl group, 2,4-dimethoxybenzyl group, 2,3-dimethoxybenzyl group, 2, 6-dimethoxybenzyl group, 3,5-dimethoxybenzyl group, 2,5-dimethoxybenzyl group, 2,4,6-trimethoxybenzyl group, 3,5-ditrifluoromethoxybenzyl group, 2-isopropoxybenzyl group, 3-chloro-4-methoxybenzyl group, 2-chloro-4-trifluoromethoxybenzyl group, 3-methyl-4-fluorobenzyl group, 4-bromo-3-trifluoromethylbenzyl group, 2-trifluoromethylbenzyl Group, 3-trifluoromethylbenzyl group, 4-trifluoromethylbenzyl group, 2-pentafluoroethylbenzyl group, 3-pentafluoroethylbenzyl group, 4-pentafluoroethylbenzyl group, 2-trifluoromethoxybenzyl group, 3-trifluoromethoxybenzyl group, 4-trifluoromethoxy Benzyl group, 2-pentafluoroethoxybenzyl group, 3-pentafluoroethoxybenzyl group, 4-pentafluoroethoxybenzyl group, 2- (2-trifluoromethylphenyl) ethyl group, 2- (3-trifluoromethylphenyl) Ethyl group, 2- (4-trifluoromethylphenyl) ethyl group, 2- (2-trifluoromethoxyphenyl) ethyl group, 2- (3-trifluoromethoxyphenyl) ethyl group, 2- (4-trifluoromethoxy) Phenyl) ethyl group, 2- (2-pentafluoroethoxyphenyl) ethyl group, 2- (3-pentafluoroethoxyphenyl) ethyl group, 2- (4-pentafluoroethoxyphenyl) ethyl group, 3- (2-tri Fluoromethylphenyl) propyl group, 3- (3-trifluoromethylphenyl) propyl Pill group, 3- (4-trifluoromethylphenyl) propyl group, 3- (2-trifluoromethoxyphenyl) propyl group, 3- (3-trifluoromethoxyphenyl) propyl group, 3- (4-trifluoromethoxy) Phenyl) propyl group, 3- (3-pentafluoroethoxyphenyl) propyl group, 3- (4-pentafluoroethoxyphenyl) propyl group, 4- (3-pentafluoroethoxyphenyl) butyl group, 5- (4-tri Fluoromethylphenyl) pentyl group, 4- (4-trifluoromethylphenyl) pentyl group, 4- (4-trifluoromethoxyphenyl) pentyl group, 6- (3-trifluoromethylphenyl) hexyl group, 6- (4 -Trifluoromethylphenyl) hexyl group, 6- (4-trifluoromethoxyphenyl) A hexyl group etc. can be mentioned.

  A piperazinyl group [on the piperazine ring at least one phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 The group may be substituted with at least one group selected from the group consisting of alkoxy groups]. For example, 1-piperazinyl group, 2-piperazinyl group, 3,4-dibenzyl -1-piperazinyl group, 2,3,4-tribenzyl-1-piperazinyl group, 4-benzyl-1-piperazinyl group, 4- (2-phenethyl) -1-piperazinyl group, 4- (3-phenylpropyl)- 1-piperazinyl group, 4- (4-phenylbutyl) -1-piperazinyl group, 4- (5-phenylpentyl) -1-piperazinyl group, 4- (6- Enylhexyl) -1-piperazinyl group, 4- (2-fluorobenzyl) -1-piperazinyl group, 4- (3-fluorobenzyl) -1-piperazinyl group, 4- (4-fluorobenzyl) -1-piperazinyl group, 4- (2-chlorobenzyl) -1-piperazinyl group, 4- (3-chlorobenzyl) -1-piperazinyl group, 4- (4-chlorobenzyl) -1-piperazinyl group, 4- (2,3-dichloro Benzyl) -1-piperazinyl group, 4- (2,4-dichlorobenzyl) -1-piperazinyl group, 4- (3,4-dichlorobenzyl) -1-piperazinyl group, 4- (3,5-dichlorobenzyl) -1-piperazinyl group, 4- (3,4,5-trichlorobenzyl) -1-piperazinyl group, 4- (2,3,4,5,6-pentafluorobenzyl) -1- Perazinyl group, 4- (2-trifluoromethylbenzyl) -1-piperazinyl group, 4- (3-trifluoromethylbenzyl) -1-piperazinyl group, 4- (4-trifluoromethylbenzyl) -1-piperazinyl group 4- (4-methylbenzyl) -1-piperazinyl group, 4- (3,4-dimethylbenzyl) -1-piperazinyl group, 4- (2,4,6-trimethylbenzyl) -1-piperazinyl group, 4 -(2-pentafluoroethylbenzyl) -1-piperazinyl group, 4- (3-pentafluoroethylbenzyl) -1-piperazinyl group, 4- (4-pentafluoroethylbenzyl) -1-piperazinyl group, 4- ( 2-trifluoromethoxybenzyl) -1-piperazinyl group, 4- (3-trifluoromethoxybenzyl) -1-piperazinyl group, 4- (4-trifluoromethoxybenzyl) -1-piperazinyl group, 4- (4-methoxybenzyl) -1-piperazinyl group, 4- (3,4-dimethoxybenzyl) -1-piperazinyl group, 4- (2 , 4,6-trimethoxybenzyl) -1-piperazinyl group, 4- (2-pentafluoroethoxybenzyl) -1-piperazinyl group, 4- (3-pentafluoroethoxybenzyl) -1-piperazinyl group, 4- ( 4-pentafluoroethoxybenzyl) -1-piperazinyl group, 4- [2- (4-trifluoromethoxyphenyl) ethyl] -1-piperazinyl group, 4- [3- (4-trifluoromethoxyphenyl) propyl]- 1-piperazinyl group, 4- [4- (4-trifluoromethoxyphenyl) butyl] -1-piperazinyl group, 4- [5- (4 Trifluoromethoxyphenyl) pentyl] -1-piperazinyl group, 4- [6- (4-trifluoromethoxyphenyl) hexyl] -1-piperazinyl group, 4- [2- (4-trifluoromethylphenyl) ethyl]- 1-piperazinyl group, 4- [3- (4-trifluoromethylphenyl) propyl] -1-piperazinyl group, 4- [4- (4-trifluoromethylphenyl) butyl] -1-piperazinyl group, 4- [ Piperazinyl groups such as 5- (4-trifluoromethylphenyl) pentyl] -1-piperazinyl group and 4- [6- (4-trifluoromethylphenyl) hexyl] -1-piperazinyl group [on the piperazine ring 1 ~ 3 phenyl C1-6 alkyl groups (on the phenyl ring, halogen atoms, halogen substituted or unsubstituted C1-6 alkyl And 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted]. Can do.

Piperidyl group [on the piperidine ring, an amino group (on the amino group, a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of 6 alkoxy groups may be substituted] and at least one group selected from the group consisting of C1-6 alkyl groups may be substituted), A phenoxy group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. And a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halo) At least one group selected from the group consisting of a group selected from the group consisting of a substituted or unsubstituted C1-6 alkoxy group may be substituted). ] May be substituted with at least one group selected from the group consisting of: 1-piperidyl group, 2-piperidyl group, 3-piperidyl group, 4-piperidyl group, 2,4- Diamino-1-piperidyl group, 2,4,6-triamino-1-piperidyl group, 2-amino-1-piperidyl group, 3-amino-1-piperidyl group, 4-amino-1-piperidyl group, 4-methyl Amino-1-piperidyl group, 4-ethylamino-1-piperidyl group, 4-n-propylamino-1-piperidyl group, 4-dimethylamino-1-piperidyl group, 4-diethylamino-1-piperyl Group, 4-di-n-propylamino-1-piperidyl group, 4-phenylamino-1-piperidyl group, 4- (N-phenyl-N-methylamino) -1-piperidyl group, 4- (2- Fluorophenylamino) -1-piperidyl group, 4- (3-fluorophenylamino) -1-piperidyl group, 4- (4-fluorophenylamino) -1-piperidyl group, 4- (2-chlorophenylamino) -1 -Piperidyl group, 4- (3-chlorophenylamino) -1-piperidyl group, 4- (4-chlorophenylamino) -1-piperidyl group, 4- (2,3-dichlorophenylamino) -1-piperidyl group, 4- (2,4,6-trifluorophenylamino) -1-piperidyl group, 4- (2,4-dichlorophenylamino) -1-piperidyl group, 4- (3,4-dichloro (Lorophenylamino) -1-piperidyl group, 4- (3,5-dichlorophenylamino) -1-piperidyl group, 4- (2,3,4,5,6-pentafluorophenylamino) -1-piperidyl group, 4- (2-trifluoromethylphenylamino) -1-piperidyl group, 4- (2-methylphenylamino) -1-piperidyl group, 4- (2,3-dimethylphenylamino) -1-piperidyl group, 4 -(2-trifluoromethylphenylamino) -1-piperidyl group, 4- (2,4,6-trimethylphenylamino) -1-piperidyl group, 4- (4-trifluoromethylphenylamino) -1-piperidyl group Group, 4- (2-pentafluoroethylphenylamino) -1-piperidyl group, 4- (3-pentafluoroethylphenylamino) -1-piperidyl Group, 4- (4-pentafluoroethylphenylamino) -1-piperidyl group, 4- (2-trifluoromethoxyphenylamino) -1-piperidyl group, 4- (2-methoxyphenylamino) -1-piperidyl group 4- (2,3-dimethoxyphenylamino) -1-piperidyl group, 4- (2,4,6-trimethoxyphenylamino) -1-piperidyl group, 4- [N-methyl-N- (2, 4,6-trimethoxyphenylamino)]-1-piperidyl group, 4- [N-methyl-N- (3,4-dimethylphenylamino)]-1-piperidyl group, 4- (3-trifluoromethoxyphenyl) Amino) -1-piperidyl group, 4- (4-trifluoromethoxyphenylamino) -1-piperidyl group, 4- (2-pentafluoroethoxyphenylamino) -1 Piperidyl group, 4- (3-pentafluoroethoxyphenylamino) -1-piperidyl group, 4- (4-pentafluoroethoxyphenylamino) -1-piperidyl group, 4-phenoxy-1-piperidyl group, 2,4- Diphenoxy-1-piperidyl group, 2,4,6-triphenoxy-1-piperidyl group, 2- (2-fluorophenoxy) -1-piperidyl group, 3- (3-fluorophenoxy) -2-piperidyl group, 4 -(4-Fluorophenoxy) -3-piperidyl group, 2- (2-chlorophenoxy) -4-piperidyl group, 3- (3-chlorophenoxy) -5-piperidyl group, 4- (4-chlorophenoxy)- 2-piperidyl group, 5- (2-bromophenoxy) -2-piperidyl group, 6- (3-bromophenoxy) -3-piperidyl group, 4- ( 4-bromophenoxy) -1-piperidyl group, 3- (2,3-dichlorophenoxy) -2-piperidyl group, 4- (3,4-dichlorophenoxy) -3-piperidyl group, 3- (2,4- Dichlorophenoxy) -4-piperidyl group, 2- (3,4,5-trichlorophenoxy) -3-piperidyl group, 6- (2,4,6-trichlorophenoxy) -2-piperidyl group, 3- (2, 3,4,5,6-pentafluorophenoxy) -1-piperidyl group, 4- (2-methylphenoxy) -1-piperidyl group, 5- (3-methylphenoxy) -2-piperidyl group, 6- (4 -Methylphenoxy) -3-piperidyl group, 1- (2-ethylphenoxy) -4-piperidyl group, 2- (3-ethylciphenoxy) -1-piperidyl group, 3- (4-ethylphenoxy) 2-piperidyl group, 4- (4-n-propylphenoxy) -3-piperidyl group, 3- (4-tert-butylphenoxy) -4-piperidyl group, 2- (4-n-butylphenoxy) -3- Piperidyl group, 1- (2-trifluoromethylphenoxy) -2-piperidyl group, 2- (3-trifluoromethylphenoxy) -1-piperidyl group, 3- (4-trifluoromethylphenoxy) -1-piperidyl group 1- (2-pentafluoroethylphenoxy) -4-piperidyl group, 1- (3-pentafluoroethylphenoxy) -4-piperidyl group, 4- (2,3-dimethylphenoxy) -1-piperidyl group, -(3,4,5-trimethylphenoxy) -4-piperidyl group, 1- (4-n-pentylphenoxy) -4-piperidyl group, 4- (4- -Hexylphenoxy) -1-piperidyl group, 4- (2-methoxyphenoxy) -1-piperidyl group, 1- (3-methoxyphenoxy) -4-piperidyl group, 1- (4-methoxyphenoxy) -4-piperidyl group Group, 2- (2-ethoxyphenoxy) -3-piperidyl group, 3- (3-ethoxyphenoxy) -4-piperidyl group, 4- (4-ethoxyphenoxy) -3-piperidyl group, 3- (4-n -Propoxyphenoxy) -2-piperidyl group, 2- (4-tert-butoxyphenoxy) -1-piperidyl group, 1- (4-n-butoxyphenoxy) -2-piperidyl group, 2- (2-trifluoromethoxy) Phenoxy) -3-piperidyl group, 3- (3-trifluoromethoxyphenoxy) -4-piperidyl group, 4- (4-trifluoromethoxy) Phenoxy) -3-piperidyl group, 3- (2-pentafluoroethoxyphenoxy) -2-piperidyl group, 2- (4-pentafluoroethoxyphenoxy) -1-piperidyl group, 1- (2,3-dimethoxyphenoxy) -4-piperidyl group, 4- (3,4,5-trimethoxyphenoxy) -1-piperidyl group, 4- (4-n-pentyloxyphenoxy) -1-piperidyl group, 4- (4-n-hexyl) Oxyphenoxy) -1-piperidyl group, 4-benzyl-1-piperidyl group, 2,4-dibenzyl-1-piperidyl group, 2,4,6-tribenzyl-1-piperidyl group, 2- (2-fluorobenzyl) -1-piperidyl group, 3- [2- (3-fluorophenyl) ethyl] -2-piperidyl group, 4- [1- (4-fluorophenyl) ethyl]- -Piperidyl group, 2- [3- (2-chlorophenyl) propyl] -4-piperidyl group, 3- [4- (3-chlorophenyl) butyl] -5-piperidyl group, 4- [5- (4-chlorophenyl) Pentyl] -2-piperidyl group, 5-([6- (2-bromophenyl) hexyl] -2-piperidyl group, 6- (3-bromobenzyl) -3-piperidyl group, 4- (4-bromobenzyl) -1-piperidyl group, 3- (2,3-dichlorobenzyl) -2-piperidyl group, 4- (3,4-dichlorobenzyl) -3-piperidyl group, 3- (2,4-dichlorobenzyl) -4 -Piperidyl group, 2- (3,4,5-trichlorobenzyl) -3-piperidyl group, 6- (2,4,6-trichlorobenzyl) -2-piperidyl group, 3- (2,3,4,5) , 6-Pentaful Robenzyl) -1-piperidyl group, 4- (2-methylbenzyl) -1-piperidyl group, 5- [2- (3-methylphenyl) ethyl] -2-piperidyl group, 6- [3- (4-methyl) Phenyl) propyl] -3-piperidyl group, 1- [4- (2-ethylphenyl) butyl] -4-piperidyl group, 2- [5- (3-ethylphenyl) pentyl] -1-piperidyl group, 3- [6- (4-ethylphenyl) hexyl] -2-piperidyl group, 4- (4-n-propylbenzyl) -3-piperidyl group, 3- (4-tert-butylbenzyl) -4-piperidyl group, 2 -(4-n-butylbenzyl) -3-piperidyl group, 1- (2-trifluoromethylbenzyl) -2-piperidyl group, 2- (3-trifluoromethylbenzyl) -1-piperidyl group, 3- ( 4 -Trifluoromethylbenzyl) -1-piperidyl group, 1- (2-pentafluoroethylbenzyl) -4-piperidyl group, 1- (3-pentafluoroethylbenzyl) -4-piperidyl group, 4- (2,3 -Dimethylbenzyl) -1-piperidyl group, 1- (3,4,5-trimethylbenzyl) -4-piperidyl group, 1- (4-n-pentylbenzyl) -4-piperidyl group, 4- (4-n -Hexylbenzyl) -1-piperidyl group, 4- (2-methoxybenzyl) -1-piperidyl group, 1- [2- (3-methoxyphenyl) ethyl] -4-piperidyl group, 1- [1- (4 -Methoxyphenyl) ethyl] -4-piperidyl group, 2- [3- (2-ethoxyphenyl) propyl] -3-piperidyl group, 3- [4- (3-ethoxyphenyl) butyl] -4 Piperidyl group, 4- [5- (4-ethoxyphenyl) pentyl] -3-piperidyl group, 3- [6- (4-n-propoxyphenyl) hexyl-2-piperidyl group, 2- (4-tert-butoxy) Benzyl) -1-piperidyl group, 1- (4-n-butoxybenzyl) -2-piperidyl group, 2- (2-trifluoromethoxybenzyl) -3-piperidyl group, 3- (3-trifluoromethoxybenzyl) -4-piperidyl group, 4- (4-trifluoromethoxybenzyl) -3-piperidyl group, 3- (2-pentafluoroethoxybenzyl) -2-piperidyl group, 2- (4-pentafluoroethoxybenzyl) -1 -Piperidyl group, 1- (2,3-dimethoxybenzyl) -4-piperidyl group, 4- (3,4,5-trimethoxybenzyl) -1-pipe A dil group, a 4- (4-n-pentyloxybenzyl) -1-piperidyl group, a 4- (4-n-hexyloxybenzyl) -1-piperidyl group, a 4-benzyl-3-phenoxy-1-piperidyl group, Piperidyl groups such as 4-phenoxy-2-methylamino-1-piperidyl group [on the piperidine ring an amino group (on the amino group a phenyl group [on the phenyl ring a halogen atom, halogen substituted or unsubstituted 1 to 5, preferably 1 to 3 groups selected from the group consisting of a C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] and C1-6 alkyl 1 to 2 groups selected from the group consisting of groups may be substituted), a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group and a phenyl C1-6 alkyl group (on the phenyl ring). Include halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and



A group selected from the group consisting of 1 to 5, preferably 1 to 3 groups selected from the group consisting of rogen-substituted or unsubstituted C1-6 alkoxy groups; May be substituted.].

  Pyrrolyl group [C1-6 alkyl group and phenyl C1-6 alkyl group on pyrrole ring (halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1 on phenyl ring) At least one group selected from the group consisting of a group selected from the group consisting of ˜6 alkoxy groups may be substituted]. 1-, 2- or 3-) pyrrolyl, 1- (4-trifluoromethoxybenzyl)-(2- or 3-) pyrrolyl, 1- (4-trifluoromethylbenzyl)-(2- or 3-) pyrrolyl 1- (4-chlorobenzyl)-(2- or 3-) pyrrolyl, 1- (4-methoxybenzyl)-(2- or 3-) pyrrolyl, 1- (4-methylbenzyl)-(2- or -) Pyrrolyl, 1- (3,4-dimethoxybenzyl)-(2- or 3-) pyrrolyl, 1- (2,4,6-trimethoxybenzyl)-(2- or 3-) pyrrolyl, 1- ( 3,4-dimethylbenzyl)-(2- or 3-) pyrrolyl, 1- (2,4,6-trimethylbenzyl)-(2- or 3-) pyrrolyl, 1- (2,4,6-trifluoro) Benzyl)-(2- or 3-) pyrrolyl, 1- (2,6-dichlorobenzyl)-(2- or 3-) pyrrolyl, 1-benzyl- (2- or 3-) pyrrolyl, 1,2-dibenzyl -(3-, 4- or 5-) pyrrolyl, 1,2,4-tribenzyl- (3- or 5-) pyrrolyl, 2- (3-chloro-4-trifluoromethoxybenzyl)-(1-, 3 -, 4- or 5-) pyrrolyl, 1-methyl- (2- or 3-) pi Yl, 1-ethyl- (2- or 3-) pyrrolyl, 1-n-propyl- (2- or 3-) pyrrolyl, 1-n-butyl- (2- or 3-) pyrrolyl, 1-n-pentyl -(2- or 3-) pyrrolyl, 1-n-hexyl- (2- or 3-) pyrrolyl, 1,3-dimethyl- (2-, 4- or 5-) pyrrolyl, 1,3,4-trimethyl -Pyrrolyl groups such as-(2- or 5-) pyrrolyl, 1-benzyl-3-methyl- (2-, 4- or 5-) pyrrolyl groups [on the pyrrole ring, a C1-6 alkyl group and an alkyl moiety A phenyl C1-6 alkyl group which is a linear or branched alkyl group having 1 to 6 carbon atoms (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group) Selected from the group consisting of C1-6 alkoxy groups 1 to 5, preferably 1 to 3 groups may be substituted), and 1 to 3 groups selected from the group consisting of 1 to 5 groups may be substituted.

  Phenylthio group (on the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. May be, for example, an unsubstituted phenylthio group and a halogen atom as defined above, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. A phenylthio group having 1 to 5, preferably 1 to 3 selected substituents, for example, phenylthio group, 2-fluorophenylthio group, 3-fluorophenylthio group, 4-fluorophenylthio group, 2-chlorophenylthio group, 3-chlorophenylthio group, 4-chlorophenylthio group, 2-bromophenyl O group, 3-bromophenylthio group, 4-bromophenylthio group, 2-iodophenylthio group, 3-iodophenylthio group, 4-iodophenylthio group, 2,3-difluorophenylthio group, 3,4 -Difluorophenylthio group, 3,5-difluorophenylthio group, 2,4-difluorophenylthio group, 2,6-difluorophenylthio group, 2,3-dichlorophenylthio group, 3,4-dichlorophenylthio group, 3 , 5-dichlorophenylthio group, 2,4-dichlorophenylthio group, 2,6-dichlorophenylthio group, 3,4,5-trifluorophenylthio group, 3,4,5-trichlorophenylthio group, 2,4, 6-trifluorophenylthio group, 2,4,6-trichlorophenylthio group, 2-fluoro-4-bromophenylthio group, 4 Chloro-3-fluorophenylthio group, 2,3,4-trichlorophenylthio group, 2,3,4,5,6-pentafluorophenylthio group, 2,4,6-trimethylphenylthio group, 4-n -Butylphenylthio group, 2,4-dimethylphenylthio group, 2,3-dimethylphenylthio group, 2,6-dimethylphenylthio group, 3,5-dimethylphenylthio group, 2,5-dimethylphenylthio group 3,5-ditrifluoromethylphenylthio group, 4-n-butoxyphenylthio group, 2,4-dimethoxyphenylthio group, 2,3-dimethoxyphenylthio group, 2,6-dimethoxyphenylthio group, 3, 5-dimethoxyphenylthio group, 2,5-dimethoxyphenylthio group, 2,4,6-trimethoxyphenylthio group, 3,5-ditrifluoromethoxy Siphenylthio group, 3-chloro-4-methoxyphenylthio group, 2-chloro-4-trifluoromethoxyphenylthio group, 3-methyl-4-fluorophenylthio group, 4-bromo-3-trifluoromethylphenylthio group 2-methylphenylthio group, 3-methylphenylthio group, 4-methylphenylthio group, 2-methyl-3-chlorophenylthio group, 3-methyl-4-chlorophenylthio group, 2-chloro-4-methylphenyl Thio group, 2-methyl-3-fluorophenylthio group, 2-trifluoromethylphenylthio group, 3-trifluoromethylphenylthio group, 4-trifluoromethylphenylthio group, 2-pentafluoroethylphenylthio group, 3-pentafluoroethylphenylthio group, 4-pentafluoroethylphenylthio group, -Isopropylphenylthio group, 3-isopropylphenylthio group, 4-isopropylphenylthio group, 2-tert-butylphenylthio group, 3-tert-butylphenylthio group, 4-tert-butylphenylthio group, 2-sec -Butylphenylthio group, 3-sec-butylphenylthio group, 4-sec-butylphenylthio group, 2-n-heptafluoropropylphenylthio group, 3-n-heptafluoropropylphenylthio group, 4-n- Heptafluoropropylphenylthio group, 4-pentylphenylthio group, 4-hexylphenylthio group, 2-methoxyphenylthio group, 3-methoxyphenylthio group, 4-methoxyphenylthio group, 3-chloro-2-methoxyphenyl A thio group, a 2-fluoro-3-methoxyphenylthio group, -Fluoro-4-methoxyphenylthio group, 2,3,4-trifluorophenylthio group, 2-trifluoromethoxyphenylthio group, 3-trifluoromethoxyphenylthio group, 4-trifluoromethoxyphenylthio group, 3 -Fluoro-2-trifluoromethoxyphenylthio group, 2-fluoro-3-trifluoromethoxyphenylthio group, 3-fluoro-4-trifluoromethoxyphenylthio group, 3-chloro-2-trifluoromethoxyphenylthio group 2-chloro-3-trifluoromethoxyphenylthio group, 3-chloro-4-trifluoromethoxyphenylthio group, 2-pentafluoroethoxyphenylthio group, 3-pentafluoroethoxyphenylthio group, 4-pentafluoroethoxy Phenylthio group, 3-chloro-2-penta Fluoroethoxyphenylthio group, 2-chloro-3-pentafluoroethoxyphenylthio group, 3-chloro-4-pentafluoroethoxyphenylthio group, 2-isopropoxyphenylthio group, 3-isopropoxyphenylthio group, 4- Isopropoxyphenylthio group, 2-tert-butoxyphenylthio group, 3-tert-butoxyphenylthio group, 4-tert-butoxyphenylthio group, 2-sec-butoxyphenylthio group, 3-sec-butoxyphenylthio group 4-sec-butoxyphenylthio group, 2-n-heptafluoropropoxyphenylthio group, 3-n-heptafluoropropoxyphenylthio group, 4-n-heptafluoropropoxyphenylthio group, 4-n-pentoxyphenyl Thio group, 4-n-hexyloxyf Niruchio group, and the like can be mentioned.

A benzothiazolyloxy group (on the benzothiazole ring, (b-1) phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1 -6 at least one group selected from the group consisting of alkoxy groups may be substituted], (b-2) piperazinyl group [on the piperazine ring, a phenyl C1-6 alkyl group (on the phenyl ring). Is substituted with at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group), phenyl C2-6 alkenyl group (consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring At least one group selected from the group may be substituted) and a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1 At least one group selected from the group consisting of ˜6 alkoxy groups may be substituted), and (b-3) piperidyl The group [on the piperidine ring is an amino group (on the amino group is a phenyl group [on the phenyl ring is a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of alkoxy groups may be substituted] and at least one group selected from the group consisting of C1-6 alkyl groups may be substituted), Si group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. And a phenyl C1-6 alkyl group (on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one group selected from the group consisting of: (b-4) a pyrrolyl group [on the pyrrole ring, C1-6 alkyl group and phenyl C1-6 alkyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted Or at least one group selected from the group consisting of a group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted). And (b-5) a phenylthio group [on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; At least one group selected from the group consisting of [which may be substituted] may be substituted], for example, 2-benzothiazolyloxy group, 4-benzothiazolyl group Ruoxy group, 5-benzothiazolyloxy group, 6-benzothiazolyloxy group, 7-benzothiazolyloxy group, 2- (1-piperazinyl) -4-benzothiazolyloxy group, 2- (4-Benzi Ru-1-piperazinyl) -4-benzothiazolyloxy group, 2- (3,4-dibenzyl-1-piperazinyl) -4-benzothiazolyloxy group, 5- (2,3,4-tribenzyl- 1-piperazinyl) -2-benzothiazolyloxy group, 4- [4- (2-phenethyl) -1-piperazinyl] -2-benzothiazolyloxy group, 4- [4- (3-phenylpropyl) -1-piperazinyl] -5-benzothiazolyloxy group, 4- [4- (4-phenylbutyl) -1-piperazinyl] -6-benzothiazolyloxy group, 4- [4- (5-phenyl) Pentyl) -1-piperazinyl] -7-benzothiazolyloxy group, 2- [4- (6-phenylhexyl) -1-piperazinyl] -4-benzothiazolyloxy group, 4- [4- (2 -Fluorobenzyl -1-piperazinyl] -2-benzothiazolyloxy group, 2- [4- (3-fluorobenzyl) -1-piperazinyl] -4-benzothiazolyloxy group, 2- [4- (4-fluoro Benzyl) -1-piperazinyl] -5-benzothiazolyloxy group, 2- [4- (2-chlorobenzyl) -1-piperazinyl] -6-benzothiazolyloxy group, 2- [4- (3 -Chlorobenzyl) -1-piperazinyl] -7-benzothiazolyloxy group, 5- [4- (4-chlorobenzyl) -1-piperazinyl] -4-benzothiazolyloxy group, 6- [4- (2,3-dichlorobenzyl) -1-piperazinyl] -4-benzothiazolyloxy group, 7- [4- (2,4-dichlorobenzyl) -1-piperazinyl] -4-benzothiazolyloxy group , 2- [4 (3,4-dichlorobenzyl) -1-piperazinyl] -4-benzothiazolyloxy group, 4- [4- (3,4-dichlorobenzyl) -1-piperazinyl] -2-benzothiazolyloxy group 4- [4- (3,4,5-trichlorobenzyl) -1-piperazinyl] -5-benzothiazolyloxy group, 4- [4- (2,3,4,5,6-pentafluorobenzyl) ) -1-piperazinyl] -2-benzothiazolyloxy group, 4- [4- (2-trifluoromethylbenzyl) -1-piperazinyl] -6-benzothiazolyloxy group, 4- [4- ( 3-trifluoromethylbenzyl) -1-piperazinyl] -7-benzothiazolyloxy group, 2- [4- (4-trifluoromethylbenzyl) -1-piperazinyl] -4-benzothiazolyloxy group, 5- [4- (4-Methylbenzyl) -1-piperazinyl] -4-benzothiazolyloxy group, 6- [4- (3,4-dimethylbenzyl) -1-piperazinyl] -4-benzothiazolyloxy group Group, 7- [4- (2,4,6-trimethylbenzyl) -1-piperazinyl] -4-benzothiazolyloxy group, 4- [4- (2-pentafluoroethylbenzyl) -1-piperazinyl] 2-benzothiazolyloxy group, 4- [4- (3-pentafluoroethylbenzyl) -1-piperazinyl] -5-benzothiazolyloxy group, 4- [4- (4-pentafluoroethylbenzyl) ) -1-piperazinyl] -6-benzothiazolyloxy group, 4- [4- (2-trifluoromethoxybenzyl) -1-piperazinyl] -7-benzothiazolyloxy group, 5- [4 (3-trifluoromethoxybenzyl) -1-piperazinyl] -4-benzothiazolyloxy group, 6- [4- (4-trifluoromethoxybenzyl) -1-piperazinyl] -5-benzothiazolyloxy group 7- [4- (4-methoxybenzyl) -1-piperazinyl] -5-benzothiazolyloxy group, 6- [4- (3,4-dimethoxybenzyl) -1-piperazinyl] -4-benzothia Zolyloxy group, 7- [4- (2,4,6-trimethoxybenzyl) -1-piperazinyl] -4-benzothiazolyloxy group, 5- [4- (2-pentafluoroethoxybenzyl)- 1-piperazinyl] -4-benzothiazolyloxy group, 4- [4- (3-pentafluoroethoxybenzyl) -1-piperazinyl] -2-benzothiazolyloxy group, 6 [4- (4-Pentafluoroethoxybenzyl) -1-piperazinyl] -4-benzothiazolyloxy group, 4- {4- [2- (4-trifluoromethoxyphenyl) ethyl] -1-piperazinyl}- 2-benzothiazolyloxy group, 4- {4- [3- (4-trifluoromethoxyphenyl) propyl] -1-piperazinyl} -2-benzothiazolyloxy group, 4- {4- [4- (4-trifluoromethoxyphenyl) butyl] -1-piperazinyl} -2-benzothiazolyloxy group, 4- {4- [5- (4-trifluoromethoxyphenyl) pentyl] -1-piperazinyl} -2 -Benzothiazolyloxy group, 4- {4- [6- (4-trifluoromethoxyphenyl) hexyl] -1-piperazinyl} -2-benzothiazolyloxy group, 4- {4- [2- (4-trifluoromethylphenyl) ethyl] -1-piperazinyl} -2-benzothiazolyloxy group, 5- {4- [3- (4-trifluoromethylphenyl) propyl]- 1-piperazinyl} -2-benzothiazolyloxy group, 6- {4- [4- (4-trifluoromethylphenyl) butyl] -1-piperazinyl} -2-benzothiazolyloxy group, 7- { 4- [5- (4-trifluoromethylphenyl) pentyl] -1-piperazinyl} -2-benzothiazolyloxy group, 5- {4- [6- (4-trifluoromethylphenyl) hexyl] -1 -Piperazinyl} -2-benzothiazolyloxy group, 2- [4- (trifluoromethoxyphenoxy-1-piperidyl)]-6-benzothiazolyloxy group, 2- [4- (trifluoro) Romethoxybenzyl-1-piperidyl)]-6-benzothiazolyloxy group, 2- {4- [N-ethyl-N- (4-chlorophenyl) amino] -1-piperidyl} -6-benzothiazolyl Oxy group, 2-phenyl-5-benzothiazolyloxy group, 2- (4-chlorophenyl) -5-benzothiazolyloxy group, 2- (4-trifluoromethoxyphenyl) -6-benzothiazolyl Oxy group, 2- (3-trifluoromethylphenyl) -5-benzothiazolyloxy group, 2- (1-piperidyl) -4-benzothiazolyloxy group, 2- (4-benzyl-1-piperidyl) ) -4-benzothiazolyloxy group, 2- (3,4-dibenzyl-1-piperidyl) -4-benzothiazolyloxy group, 5- (2,3,4-tribenzyl-1-piperidyl) 2-benzothiazolyloxy group, 4- [4- (2-phenethyl) -1-piperidyl] -2-benzothiazolyloxy group, 4- [4- (3-phenylpropyl) -1-piperidyl ] -5-benzothiazolyloxy group, 4- [4- (4-phenylbutyl) -1-piperidyl] -6-benzothiazolyloxy group, 4- [4- (5-phenylpentyl) -1 -Piperidyl] -7-benzothiazolyloxy group, 2- [4- (6-phenylhexyl) -1-piperidyl) -4-benzothiazolyloxy group, 4- [4- (2-fluorobenzyl) -1-piperidyl] -2-benzothiazolyloxy group, 2- [4- (3-fluorobenzyl) -1-piperidyl] -4-benzothiazolyloxy group, 2- [4- (4-fluoro) Benzyl) -1-piperazinyl] -5-benzothiazolyloxy group, 2- [4- (2-chlorobenzyl) -1-piperidyl] -6-benzothiazolyloxy group, 2- [4- (3-chlorobenzyl) -1- Piperidyl] -7-benzothiazolyloxy group, 5- [4- (4-chlorobenzyl) -1-piperidyl] -4-benzothiazolyloxy group, 6- [4- (2,3-dichlorobenzyl) ) -1-piperidyl] -4-benzothiazolyloxy group, 7- [4- (2,4-dichlorobenzyl) -1-piperidyl] -4-benzothiazolyloxy group, 2- [4- ( 3,4-dichlorobenzyl) -1-piperidyl] -4-benzothiazolyloxy group, 4- [4- (3,5-dichlorobenzyl) -1-piperidyl] -2-benzothiazolyloxy group, 4- [4- (3,4,5-trichlorobe Yl) -1-piperidyl] -5-benzothiazolyloxy group, 4- [4- (2,3,4,5,6-pentafluorobenzyl) -1-piperidyl] -2-benzothiazolyloxy Group, 4- [4- (2-trifluoromethylbenzyl) -1-piperidyl] -6-benzothiazolyloxy group, 4- [4- (3-trifluoromethylbenzyl) -1-piperidyl] -7 -Benzothiazolyloxy group, 2- [4- (4-trifluoromethylbenzyl) -1-piperidyl] -4-benzothiazolyloxy group, 5- [4- (4-methylbenzyl) -1- Piperidyl] -4-benzothiazolyloxy group, 6- [4- (3,4-dimethylbenzyl) -1-piperidyl] -4-benzothiazolyloxy group, 7- [4- (2,4,4) 6-trimethylbenzyl) -1- Peridyl] -4-benzothiazolyloxy group, 4- [4- (2-pentafluoroethylbenzyl) -1-piperidyl] -2-benzothiazolyloxy group, 4- [4- (3-pentafluoro Ethylbenzyl) -1-piperidyl] -5-benzothiazolyloxy



Group, 4- [4- (4-pentafluoroethylbenzyl) -1-piperidyl] -6-benzothiazolyloxy group, 4- [4- (2-trifluoromethoxybenzyl) -1-piperidyl] -7 -Benzothiazolyloxy group, 5- [4- (3-trifluoromethoxybenzyl) -1-piperidyl] -4-benzothiazolyloxy group, 6- [4- (4-trifluoromethoxybenzyl)- 1-piperidyl] -5-benzothiazolyloxy group, 7- [4- (4-methoxybenzyl) -1-piperidyl] -5-benzothiazolyloxy group, 6- [4- (3,4- Dimethoxybenzyl) -1-piperidyl] -4-benzothiazolyloxy group, 7- [4- (2,4,6-trimethoxybenzyl) -1-piperidyl] -4-benzothiazolyloxy group, 5 -[4 (2-pentafluoroethoxybenzyl) -1-piperidyl] -4-benzothiazolyloxy group, 4- [4- (3-pentafluoroethoxybenzyl) -1-piperidyl] -2-benzothiazolyloxy group , 6- [4- (4-pentafluoroethoxybenzyl) -1-piperidyl] -4-benzothiazolyloxy group, 4- {4- [2- (4-trifluoromethoxyphenyl) ethyl] -1- Piperidyl} -2-benzothiazolyloxy group, 4- {4- [3- (4-trifluoromethoxyphenyl) propyl] -1-piperidyl} -2-benzothiazolyloxy group, 4- {4- [4- (4-trifluoromethoxyphenyl) butyl] -1-piperidyl} -2-benzothiazolyloxy group, 4- {4- [5- (4-trifluoromethoxypheny] ) Pentyl] -1-piperidyl} -2-benzothiazolyloxy group, 4- {4- [6- (4-trifluoromethoxyphenyl) hexyl] -1-piperidyl} -2-benzothiazolyloxy group 4- {4- [2- (4-trifluoromethylphenyl) ethyl] -1-piperidyl} -2-benzothiazolyloxy group, 5- {4- [3- (4-trifluoromethylphenyl) Propyl] -1-piperidyl} -2-benzothiazolyloxy group, 6- {4- [4- (4-trifluoromethylphenyl) butyl] -1-piperidyl} -2-benzothiazolyloxy group, 7- {4- [5- (4-trifluoromethylphenyl) pentyl] -1-piperidyl} -2-benzothiazolyloxy group, 5- {4- [6- (4-trifluoromethylphenyl) hexyl L] -1-piperidyl} -2-benzothiazolyloxy group, 2- (4-phenoxy-1-piperidyl) -4-benzothiazolyloxy group, 2- (3,4-diphenoxy-1-piperidyl) ) -4-benzothiazolyloxy group, 5- (2,3,4-triphenoxy-1-piperidyl) -2-benzothiazolyloxy group, 4- [4- (2-fluorophenoxy) -1 -Piperidyl] -2-benzothiazolyloxy group, 2- [4- (3-fluorophenoxy) -1-piperidyl] -4-benzothiazolyloxy group, 2- [4- (4-fluorophenoxy) -1-piperazinyl] -5-benzothiazolyloxy group, 2- [4- (2-chlorophenoxy) -1-piperidyl] -6-benzothiazolyloxy group, 2- [4- (3-chloro Phenoxy) -1- Peridyl] -7-benzothiazolyloxy group, 5- [4- (4-chlorophenoxy) -1-piperidyl] -4-benzothiazolyloxy group, 6- [4- (2,3-dichlorophenoxy) ) -1-piperidyl] -4-benzothiazolyloxy group, 7- [4- (2,4-dichlorophenoxy) -1-piperidyl] -4-benzothiazolyloxy group, 2- [4- ( 3,4-dichlorophenoxy) -1-piperidyl] -4-benzothiazolyloxy group, 4- [4- (3,5-dichlorophenoxy) -1-piperidyl] -2-benzothiazolyloxy group, 4- [4- (3,4,5-trichlorophenoxy) -1-piperidyl] -5-benzothiazolyloxy group, 4- [4- (2,3,4,5,6-pentafluorophenoxy) -1-piperidyl] -2- Nzothiazolyloxy group, 4- [4- (2-trifluoromethylphenoxy) -1-piperidyl] -6-benzothiazolyloxy group, 4- [4- (3-trifluoromethylphenoxy)- 1-piperidyl] -7-benzothiazolyloxy group, 2- [4- (4-trifluoromethylphenoxy) -1-piperidyl] -4-benzothiazolyloxy group, 5- [4- (4- Methylphenoxy) -1-piperidyl] -4-benzothiazolyloxy group, 6- [4- (3,4-dimethylphenoxy) -1-piperidyl] -4-benzothiazolyloxy group, 7- [4 -(2,4,6-trimethylphenoxy) -1-piperidyl] -4-benzothiazolyloxy group, 4- [4- (2-pentafluoroethylphenoxy) -1-piperidyl] -2-benzothiazo Ryloxy group, 4- [4- (3-pentafluoroethylphenoxy) -1-piperidyl] -5-benzothiazolyloxy group, 4- [4- (4-pentafluoroethylphenoxy) -1-piperidyl]- 6-benzothiazolyloxy group, 4- [4- (2-trifluoromethoxyphenoxy) -1-piperidyl] -7-benzothiazolyloxy group, 5- [4- (3-trifluoromethoxyphenoxy) -1-piperidyl] -4-benzothiazolyloxy group, 6- [4- (4-trifluoromethoxyphenoxy) -1-piperidyl] -5-benzothiazolyloxy group, 7- [4- (4 -Methoxyphenoxy) -1-piperidyl] -5-benzothiazolyloxy group, 6- [4- (3,4-dimethoxyphenoxy) -1-piperidyl] -4-benzothia Ryloxy group, 7- [4- (2,4,6-trimethoxyphenoxy) -1-piperidyl] -4-benzothiazolyloxy group, 5- [4- (2-pentafluoroethoxyphenoxy) -1- Piperidyl] -4-benzothiazolyloxy group, 4- [4- (3-pentafluoroethoxyphenoxy) -1-piperidyl] -2-benzothiazolyloxy group, 6- [4- (4-pentafluoro) Ethoxyphenoxy) -1-piperidyl] -4-benzothiazolyloxy group, 2,5,6-triphenyl-7-benzothiazolyloxy group, 2- (4-amino-1-piperidyl) -6 Benzothiazolyloxy group, 4- (2,4-diamino-1-piperidyl) -2-benzothiazolyloxy group, 5- (2,4,6-triamino-1-piperidyl) -4-benzo Azolyloxy group, 6- (2-amino-1-piperidyl) -5-benzothiazolyloxy group, 7- (3-amino-1-piperidyl) -6-benzothiazolyloxy group, 2- (4- Methylamino-1-piperidyl) -4-benzothiazolyloxy group, 2- (4-ethylamino-1-piperidyl) -5-benzothiazolyloxy group, 2- (4-n-propylamino-1) -Piperidyl) -6-benzothiazolyloxy group, 2- (4-dimethylamino-1-piperidyl) -7-benzothiazolyloxy group, 2- (4-diethylamino-1-piperidyl) -4-benzo Thiazolyloxy group, 2- (4-di-n-propylamino-1-piperidyl) -5-benzothiazolyloxy group, 2- (4-phenylamino-1-piperidyl) -6-benzothiazolyl Oxy group, 2- [4- (N-phenyl-N-methylamino) -1-piperidyl] -7-benzothiazolyloxy group, 2- [4- (2-fluorophenylamino) -1-piperidyl] -4-benzothiazolyloxy group, 2- [4- (3-fluorophenylamino) -1-piperidyl] -5-benzothiazolyloxy group, 2- [4- (4-fluorophenylamino)- 1-piperidyl] -6-benzothiazolyloxy group, 2- [4- (2-chlorophenylamino) -1-piperidyl] -7-benzothiazolyloxy group, 2- [4- (3-chlorophenylamino) ) -1-piperidyl] -4-benzothiazolyloxy group, 2- [4- (4-chlorophenylamino) -1-piperidyl] -5-benzothiazolyloxy group, 2- [4- (2, 3-dichloro Enylamino) -1-piperidyl] -6-benzothiazolyloxy group, 2- [4- (2,4,6-trifluorophenylamino) -1-piperidyl] -7-benzothiazolyloxy group, 2 -[4- (2,4-dichlorophenylamino) -1-piperidyl] -4-benzothiazolyloxy group, 2- [4- (3,4-dichlorophenylamino) -1-piperidyl] -6-benzothia Zolyloxy group, 4- (3,5-dichlorophenylamino) -1-piperidyl] -5-benzothiazolyloxy group, 2- [4- (2,3,4,5,6-pentafluorophenylamino) ) -1-piperidyl] -6-benzothiazolyloxy group, 2- [4- (2-trifluoromethylphenylamino) -1-piperidyl] -7-benzothiazolyloxy group, 2- [4- 2-methylphenylamino) -1-piperidyl] -4-benzothiazolyloxy group, 2- [4- (2,3-dimethylphenylamino) -1-piperidyl] -5-benzothiazolyloxy group, 2- [4- (2-trifluoromethylphenylamino) -1-piperidyl] -6-benzothiazolyloxy group, 2- [4- (2,4,6-trimethylphenylamino) -1-piperidyl] -7-benzothiazolyloxy group, 2- [4- (4-trifluoromethylphenylamino) -1-piperidyl] -4-benzothiazolyloxy group, 2- [4- (2-pentafluoroethyl) Phenylamino) -1-piperidyl] -5-benzothiazolyloxy group, 2- [4- (3-pentafluoroethylphenylamino) -1-piperidyl] -5-benzothiazolyloxy Xyl group, 2- [4- (4-pentafluoroethylphenylamino) -1-piperidyl] -6-benzothiazolyloxy group, 2- [4- (2-trifluoromethoxyphenylamino) -1-piperidyl ] -7-benzothiazolyloxy group, 2- [4- (2-methoxyphenylamino) -1-piperidyl] -4-benzothiazolyloxy group, 2- [4- (2,3-dimethoxyphenyl) Amino) -1-piperidyl] -5-benzothiazolyloxy group, 2- [4- (2,4,6-trimethoxyphenylamino) -1-piperidyl] -6-benzothiazolyloxy group, 2 -{4- [N-methyl-N- (2,4,6-trimethoxyphenylamino)]-1-piperidyl} -7-benzothiazolyloxy group, 2- {4- [N-methyl-N -(3,4-dimethyl) Phenylamino)]-1-piperidyl} -4-benzothiazolyloxy group, 2- [4- (3-trifluoromethoxyphenylamino) -1-piperidyl] -5-benzothiazolyloxy group, 2- [4- (4-Trifluoromethoxyphenylamino) -1-piperidyl] -6-benzothiazolyloxy group, 2- [4- (2-pentafluoroethoxyphenylamino) -1-piperidyl] -7-benzo Thiazolyloxy group, 2- [4- (3-pentafluoroethoxyphenylamino) -1-piperidyl] -4-benzothiazolyloxy group, 2- [4- (4-pentafluoroethoxyphenylamino)- 1-piperidyl] -5-benzothiazolyloxy group, 2- [4- (2-fluorophenylamino) -1-piperidyl] -5-benzothiazolyl Xyl group, 4- (3-fluorophenylamino) -1-piperidyl] -6-benzothiazolyloxy group, 2- [4- (4-fluorophenylamino) -1-piperidyl] -7-benzothiazolyl Ruoxy group, 2-phenyl-5- (4-phenoxy-1-piperidyl) -7-benzothiazolyloxy group, 2- [1- (4-trifluoromethoxyphenyl)-(2- or 3-) Pyrrolyl]-(4-, 5-, 6- or 7-) benzothiazolyloxy group, 2- [1-methyl- (2- or 3-) pyrrolyl]-(4-, 5-, 6- or 7-) benzothiazolyloxy group, 2- {4- [3- (4-trifluoromethylphenyl) -2-propenyl]-(1-, 2- or 3-) piperazinyl}-(4--5 -, 6- or 7-) benzothiazolyloxy group, 2- [4 -(4-trifluoromethoxyphenyl)]-(1-, 2- or 3-) piperazinyl- (4-, 5-, 6- or 7-) benzothiazolyloxy group, 2- [4- (4 -Trifluoromethylphenyl)]-(1-, 2- or 3-) piperazinyl- (4-, 5-, 6- or 7-



) A benzothiazolyloxy group such as a benzothiazolyloxy group, 2- (4-chlorophenylthio)-(4-, 5-, 6- or 7-) benzothiazolyloxy group (B-1) a phenyl group [on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; At least one of them may be substituted], (b-2) a piperazinyl group [on the piperazine ring, a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1 A group selected from the group consisting of -6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted), and the alkenyl moiety has 2 to 6 carbon atoms and a double bond The 1 to 3 linear or branched alkenyl groups, including both trans and cis isomers, phenyl C2-6 alkenyl groups (on the phenyl ring, halogen atoms, halogen substituted or unsubstituted 1 to 5, preferably 1 to 3 groups selected from the group consisting of a C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group, and a phenyl group (phenyl On the ring, there are 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. 1 to 3 groups selected from the group consisting of optionally substituted) may be substituted], (b-3) a piperidyl group [on the piperidine ring, an amino group (on the amino group). , Phenyl group [phenyl ring May be substituted with at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] and At least one group selected from the group consisting of C1-6 alkyl groups may be substituted), a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and At least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted, and phenyl C1-6 alkyl groups (on the phenyl ring, halogen atoms, halogen-substituted Or at least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one of the groups selected from the group consisting of optionally substituted), (b-4) pyrrolyl group [on the pyrrole ring, a C1-6 alkyl group and phenyl] C1-6 alkyl group (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is 1-5 A group selected from the group consisting of 1 to 3, preferably 1 to 3) may be substituted] and (b-5) a phenylthio group [on the phenyl ring, 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group Selected from the group consisting of 1 to 3 of these groups may be substituted].

  Piperazinyl group [on the piperazine ring, a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one group selected from the group may be substituted), a phenyl group [phenoxy group on the phenyl ring (halogen atom, halogen-substituted or unsubstituted C1-6 alkyl on the phenyl ring) A group selected from the group consisting of a group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen At least one group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted] and An aryl C2-6 alkenyl group [on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; The at least one group selected from the group of which the species may be substituted may be substituted] includes the piperazinyl group [on the piperazine ring, at least one phenyl C1-6 alkyl. Group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. May be substituted)] in addition to 4- [3- (4-trifluoromethylphenyl) -2-propenyl]-(1-, 2- Is 3-) piperazinyl group, 4- (4-methoxyphenyl)-(1-, 2- or 3-) piperazinyl group, 4- (3,4-dimethylphenyl)-(1-, 2- or 3-) Piperazinyl group, 4- (4-fluorophenyl)-(1-, 2- or 3-) piperazinyl group, 4- (4-trifluoromethylphenyl)-(1-, 2- or 3-) piperazinyl group, 4 -(4-methylphenyl)-(1-, 2- or 3-) piperazinyl group, 4- (3,4-dichlorophenyl)-(1-, 2- or 3-) piperazinyl group, 4- (4-tri Piperazinyl groups such as fluoromethoxyphenyl)-(1-, 2- or 3-) piperazinyl group, 4- [4- (4-chlorophenoxy) phenyl]-(1-, 2- or 3-) piperazinyl group [piperazine On the ring, phenyl C1-6 An alkyl group (on the phenyl ring, preferably 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group, 1 to 3 may be substituted), a phenyl group [on the phenyl ring, a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted 1 to 5, preferably 1 to 3 groups selected from the group consisting of substituted C1-6 alkoxy groups), halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups, and 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups] and alkenyl moieties A linear or branched alkenyl group having a prime number of 2 to 6 and having 1 to 3 double bonds, including both trans isomers and cis isomers [on the phenyl ring; Is substituted with 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups. May be substituted with 1 to 3 groups selected from the group].

  Examples of the naphthyl C1-6 alkyl group include [(1- or 2-) naphthyl] methyl group, 1-[(1- or 2-) naphthyl] ethyl group, and 2-[(1- or 2-) naphthyl. ] Ethyl group, 3-[(1- or 2-) naphthyl] propyl group, 2-[(1- or 2-) naphthyl] propyl group, 4-[(1- or 2-) naphthyl] butyl group, 5 -[(1- or 2-) naphthyl] pentyl group, 4-[(1- or 2-) naphthyl] pentyl group, 6-[(1- or 2-) naphthyl] hexyl group, 2-methyl-3- A linear or branched chain having 1 to 6 carbon atoms of an alkyl moiety such as [(1- or 2-) naphthyl] propyl group or 1,1-dimethyl-2-[(1- or 2-) naphthyl] ethyl group An example is a naphthylalkyl group that is an alkyl group.

  A phenyl C1-6 alkylidene group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group; The species may be substituted), for example, benzylidene group, 1-phenylethylidene group, 2-phenylethylidene group, 3-phenylpropylidene group, 2-phenylpropylidene group, 4-phenylbutylidene group, 5- Phenylpentylidene group, 4-phenylpentylidene group, 6-phenylhexylidene group, 2-fluorobenzylidene group, 3-fluorobenzylidene group, 4-fluorobenzylidene group, 2-chlorobenzylidene group, 3-chlorobenzylidene group, 4-chlorobenzylidene group, 2-bromobenzylidene group, 3 Bromobenzylidene group, 4-bromobenzylidene group, 2-iodobenzylidene group, 3-iodobenzylidene group, 4-iodobenzylidene group, 2,3-difluorobenzylidene group, 3,4-difluorobenzylidene group, 3,5-difluorobenzylidene Group, 2,4-difluorobenzylidene group, 2,6-difluorobenzylidene group, 2,3-dichlorobenzylidene group, 3,4-dichlorobenzylidene group, 3,5-dichlorobenzylidene group, 2,4-dichlorobenzylidene group, 2,6-dichlorobenzylidene group, 2-fluoro-4-bromobenzylidene group, 4-chloro-3-fluorobenzylidene group, 2,3,4-trichlorobenzylidene group, 3,4,5-trifluorobenzylidene group, 2 , 4,6-trichlorobenzylidene group, 4-isopro Rubenzylidene group, 4-n-butylbenzylidene group, 4-methylbenzylidene group, 2-methylbenzylidene group, 3-methylbenzylidene group, 2,4-dimethylbenzylidene group, 2,3-dimethylbenzylidene group, 2,6- Dimethylbenzylidene group, 3,5-dimethylbenzylidene group, 2,5-dimethylbenzylidene group, 2,4,6-trimethylbenzylidene group, 3,5-ditrifluoromethylbenzylidene group, 2,3,4,5,6- Pentafluorobenzylidene group, 4-isopropoxybenzylidene group, 4-n-butoxybenzylidene group, 4-methoxybenzylidene group, 2-methoxybenzylidene group, 3-methoxybenzylidene group, 2,4-dimethoxybenzylidene group, 2,3- Dimethoxybenzylidene group, 2,6-dimethoxybenzylidene Group, 3,5-dimethoxybenzylidene group, 2,5-dimethoxybenzylidene group, 2,4,6-trimethoxybenzylidene group, 3,5-ditrifluoromethoxybenzylidene group, 2-isopropoxybenzylidene group, 3-chloro- 4-methoxybenzylidene group, 2-chloro-4-trifluoromethoxybenzylidene group, 3-methyl-4-fluorobenzylidene group, 4-bromo-3-trifluoromethylbenzylidene group, 2-trifluoromethylbenzylidene group, 3- Trifluoromethylbenzylidene group, 4-trifluoromethylbenzylidene group, 2-pentafluoroethylbenzylidene group, 3-pentafluoroethylbenzylidene group, 4-pentafluoroethylbenzylidene group, 2-trifluoromethoxybenzylidene group, 3-trifluoromethyl Xibenzylidene group, 4-trifluoromethoxybenzylidene group, 2-pentafluoroethoxybenzylidene group, 3-pentafluoroethoxybenzylidene group, 4-pentafluoroethoxybenzylidene group, 2- (2-trifluoromethylphenyl) ethylidene group, 2 -(3-trifluoromethylphenyl) ethylidene group, 2- (4-trifluoromethylphenyl) ethylidene group, 2- (2-trifluoromethoxyphenyl) ethylidene group, 2- (3-trifluoromethoxyphenyl) ethylidene group 2- (4-trifluoromethoxyphenyl) ethylidene group, 2- (2-pentafluoroethoxyphenyl) ethylidene group, 2- (3-pentafluoroethoxyphenyl) ethylidene group, 2- (4-pentafluoroethoxyphenyl) Echili Group, 3- (2-trifluoromethylphenyl) propylidene group, 3- (3-trifluoromethylphenyl) propylidene group, 3- (4-trifluoromethylphenyl) propylidene group, 3- (2-trifluoromethoxy) Phenyl) propylidene group, 3- (3-trifluoromethoxyphenyl) propylidene group, 3- (4-trifluoromethoxyphenyl) propylidene group, 3- (3-pentafluoroethoxyphenyl) propylidene group, 3- (4-penta) Fluoroethoxyphenyl) propylidene group, 4- (3-pentafluoroethoxyphenyl) butylidene group, 5- (4-trifluoromethylphenyl) pentylidene group, 4- (4-trifluoromethylphenyl) pentylidene group, 4- (4 -Trifluoromethoxyphenyl) pentyl A phenyl C1-6 alkylidene group such as a den group, 6- (3-trifluoromethylphenyl) hexylidene group, 6- (4-trifluoromethylphenyl) hexylidene group, 6- (4-trifluoromethoxyphenyl) hexylidene group ( 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring, preferably 1 to 3 may be substituted).

  Piperazinyl group [C1-6 alkoxycarbonyl group on piperazine ring, Furyl C1-6 alkyl group [At least one phenyl group on furan ring (halogen atom, halogen substituted or unsubstituted on phenyl ring) At least one group selected from the group consisting of a C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted], pyridyl C1 6 alkyl group [furyl group and phenyl group on pyridine ring (on phenyl ring, consisting of halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group At least one group selected from the group consisting of a group selected from the group consisting of at least one group selected from the group may be substituted], Zothienyl C1-6 alkyl group (on the benzothiophene ring, at least a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) 1 type may be substituted), phenyl C2-6 alkenyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group) Or at least one group selected from the group consisting of: a benzofuryl C1-6 alkyl group [on the benzofuran ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen; At least one group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted], Zofuryl C2-6 alkenyl group [on the benzofuran ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. A seed may be substituted], thiazolyl C1-6 alkyl group [on the thiazole ring at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group And at least one group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted], a phenoxy C1-6 alkyl group (phenyl ring). It consists of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. At least one group selected from the group may be substituted), an indolyl C1-6 alkyl group (on the indole ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or At least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted, and a phenyl C1-6 alkyl group (on the phenyl ring, a benzofuryl group, a halogen atom, a halogen substitution) Or at least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted). One type may be substituted, for example, the piperazinyl group [on the piperazine ring, at least one phenyl C1-6 alkyl group (containing On the nyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. May be substituted) in addition to 4-tert-butoxycarbonyl- (1-, 2- or 3-) piperazinyl group, 4- {4-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] benzyl}-(1-, 2- or 3-) piperazinyl group, 4- {3-[(2- or 3-) furyl] pyridylmethyl}-(1-, 2- or 3-) piperazinyl group, 4- [2- (4-trifluoromethoxyphenyl) pyridylmethyl]-(1-, 2- or 3-) piperazinyl group, 4- [2- (3-chloro-4 -Fluorophenyl) pyridylmethyl]-(1 , 2- or 3-) piperazinyl group, 4- [5-trifluoromethyl- (2-, 3-, 4-, 6- or 7-) benzofurylmethyl]-(1-, 2- or 3-) Piperazinyl group, 4- [6-trifluoromethyl- (2-, 3-, 4-, 5- or 7-) benzofurylmethyl]-(1-, 2- or 3-) piperazinyl group, 4- [5 -Chloro- (2-, 3-, 4-, 6- or 7-) benzothienylmethyl]-(1-, 2- or 3-) piperazinyl group, 4- [6-chloro- (2-, 3- , 4-, 5- or 7-) benzofurylmethyl]-(1-, 2- or 3-) piperazinyl group, 4- [5-trifluoromethoxy- (2-, 3-, 4-, 6- or 7-) benzofurylmethyl]-(1-, 2- or 3-) piperazinyl group, 4- [3- (4-trifluoromethyl) Phenyl) -2-propenyl]-(1-, 2- or 3-) piperazinyl group, 4- [3- (3,4-dichlorophenyl) -2-propenyl]-(1-, 2- or 3-) piperazinyl A group, 4- [3- (4-chlorophenyl) -2-propenyl]-(1-, 2- or 3-) piperazinyl group, 4- {3- [6-trifluoromethyl- (2-, 3-, 4-, 5- or 7-) benzofuryl] -2-propenyl}-(1-, 2- or 3-) piperazinyl group, 4- {3- [5-chloro- (2-, 3-, 4-, 5- or 7-) benzofuryl] -2-propenyl}-(1-, 2- or 3-) piperazinyl group, 4- [5-chloro- (2-, 3-, 4-, 6- or 7-) Benzofurylmethyl]-(1-, 2- or 3-) piperazinyl group, 4- [2- (4-trifluoro) Tilphenyl)-(4- or 5-) thiazolylmethyl]-(1-, 2- or 3-) piperazinyl group, 4- [2- (4-trifluoromethoxyphenoxy) ethyl]-(1-, 2- or 3 -) Piperazinyl group, 4- [3- (4-trifluoromethoxyphenyl) -2-propenyl]-(1-, 2- or 3-) piperazinyl group, 4- [5-trifluoromethoxy- (1-, 2-, 3-, 4-, 6- or 7-) indolylmethyl]-(1-, 2- or 3-) piperazinyl group, 4- [2- (4-chlorophenyl)-(3-, 4- Or 5-) furylmethyl]-(1-, 2- or 3-) piperazinyl group, 4- [2- (2-chloro-5-trifluoromethylphenyl)-(3-, 4- or 5-) furyl Methyl]-(1-, 2- or 3-) piperazinyl group, etc. A C1-6 alkoxycarbonyl group on the piperazine ring, a furyl C1-6 alkyl group in which the alkyl portion is a linear or branched alkyl group having 1 to 6 carbon atoms [on the furan ring, 1 to 3 A phenyl group (on the phenyl ring, 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group, Preferably 1 to 3 may be substituted)], a pyridyl C1-6 alkyl group in which the alkyl portion is a linear or branched alkyl group having 1 to 6 carbon atoms [pyridine] On the ring, a furyl group and a phenyl group (on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group) A group selected from the group consisting of 1 to 5, preferably 1 to 3 groups) may be substituted]; 6 straight-chain or branched alkyl groups benzothienyl C1-6 alkyl group (on the benzothiophene ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1 1 to 3 groups selected from the group consisting of -6 alkoxy groups may be substituted), a straight or branched chain having 2 to 6 carbon atoms in the alkenyl moiety and 1 to 3 double bonds A phenyl C2-6 alkenyl group including a trans isomer and a cis isomer (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or non-substituted alkenyl group). Substitution C1-6 1 to 5 groups, preferably 1 to 3 groups selected from the group consisting of alkoxy groups may be substituted), and the alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms. A benzofuryl C1-6 alkyl group [on the benzofuran ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; 3 may be substituted], a straight or branched alkenyl group having 2 to 6 carbon atoms in the alkenyl moiety and 1 to 3 double bonds, Including benzofuryl C2-6 alkenyl group [on the benzofuran ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group 1 to 3 of the selected groups may be substituted], a thiazolyl C1-6 alkyl group in which the alkyl portion is a linear or branched alkyl group having 1 to 6 carbon atoms [on the thiazole ring 1 to 2 phenyl groups (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) 1 to 5, preferably 1 to 3 may be substituted)], and the alkyl moiety is a straight-chain or branched alkyl group having 1 to 6 carbon atoms. 6 alkyl group (on the phenyl ring, 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group, Preferably 1 to 3 substitutions An indolyl C1-6 alkyl group in which the alkyl portion is a linear or branched alkyl group having 1 to 6 carbon atoms (on the indole ring, a halogen atom, halogen-substituted or unsubstituted C1) 1 to 6 alkyl groups and 1 to 3 groups selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted, and phenyl C1-6 alkyl groups (on the phenyl ring, 1 to 5, preferably 1 to 3 groups selected from the group consisting of benzofuryl group, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group A group selected from the group consisting of 1 to 3) may be substituted.

Piperidyl group [on the piperidine ring, an amino group (on the amino group, a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of 6 alkoxy groups may be substituted] and at least one group selected from the group consisting of C1-6 alkyl groups may be substituted); A phenoxy group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. A phenyl C1-6 alkyl group (on the phenyl ring, a C1-4 alkylenedioxy group, a halogen atom, halogen-substituted or unsubstituted) At least one group selected from the group consisting of a C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted; a phenyl C1-6 alkoxy group (on the phenyl ring) A halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted); a phenyl group (On the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. Naphthyl C1-6 alkyl group and phenyl C1-6 alkylidene group (on the phenyl ring, a halogen atom, a halogen atom) A group selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group). Can be substituted, for example, 1-piperidyl group, 2-piperidyl group, 3-piperidyl group, 4-piperidyl group, 2,4-diamino-1-piperidyl group, 2, 4,6-triamino-1-piperidyl group, 2-amino-1-piperidyl group, 3-amino-1-piperidyl group, 4-amino-1-piperidyl group, 4-methylamino-1-piperidyl group, 4- Ethylamino-1-piperidyl group, 4-n-propylamino-1-piperidyl group, 4-dimethylamino-1-piperidyl group, 4-diethylamino-1-piperidyl group, 4- Di-n-propylamino-1-piperidyl group, 4-phenylamino-1-piperidyl group, 4- (N-phenyl-N-methylamino) -1-piperidyl group, 4- (2-fluorophenylamino)- 1-piperidyl group, 4- (3-fluorophenylamino) -1-piperidyl group, 4- (4-fluorophenylamino) -1-piperidyl group, 4- (2-chlorophenylamino) -1-piperidyl group, 4 -(3-chlorophenylamino) -1-piperidyl group, 4- (4-chlorophenylamino) -1-piperidyl group, 4- (2,3-dichlorophenylamino) -1-piperidyl group, 4- (2,4, 6-trifluorophenylamino) -1-piperidyl group, 4- (2,4-dichlorophenylamino) -1-piperidyl group, 4- (3,4-dichloropheny Amino) -1-piperidyl group, 4- (3,5-dichlorophenylamino) -1-piperidyl group, 4- (2,3,4,5,6-pentafluorophenylamino) -1-piperidyl group, 4- (2-trifluoromethylphenylamino) -1-piperidyl group, 4- (2-methylphenylamino) -1-piperidyl group, 4- (2,3-dimethylphenylamino) -1-piperidyl group, 4- ( 3-trifluoromethylphenylamino) -1-piperidyl group, 4- (2,4,6-trimethylphenylamino) -1-piperidyl group, 4- (4-trifluoromethylphenylamino) -1-piperidyl group, 4- (2-pentafluoroethylphenylamino) -1-piperidyl group, 4- (3-pentafluoroethylphenylamino) -1-piperidyl group, 4- 4-pentafluoroethylphenylamino) -1-piperidyl group, 4- (2-trifluoromethoxyphenylamino) -1-piperidyl group, 4- (2-methoxyphenylamino) -1-piperidyl group, 4- (2 , 3-Dimethoxyphenylamino) -1-piperidyl group, 4- (2,4,6-trimethoxyphenylamino) -1-piperidyl group, 4- [N-methyl-N- (2,4,6-tri Methoxyphenylamino)]-1-piperidyl group, 4- [N-methyl-N- (3,4-dimethylphenylamino)]-1-piperidyl group, 4- [N-ethyl-N- (4-chlorophenylamino) )]-1-piperidyl group, 4- (3-trifluoromethoxyphenylamino) -1-piperidyl group, 4- (4-trifluoromethoxyphenylamino) -1-piperid Zyl group, 4- (2-pentafluoroethoxyphenylamino) -1-piperidyl group, 4- (3-pentafluoroethoxyphenylamino) -1-piperidyl group, 4- (4-pentafluoroethoxyphenylamino) -1 -Piperidyl group, 4- [N-methyl-N- (2-fluorophenyl) amino] -1-piperidyl group, 4- [N-methyl-N- (3-fluorophenyl) amino] -1-piperidyl group, 4- [N-methyl-N- (4-fluorophenyl) amino] -1-piperidyl group, 4-phenoxy-1-piperidyl group, 2,4-diphenoxy-1-piperidyl group, 2,4,6-tri Phenoxy-1-piperidyl group, 2- (2-fluorophenoxy) -1-piperidyl group, 3- (3-fluorophenoxy) -2-piperidyl group, 4- (4-fluoro Olophenoxy) -3-piperidyl group, 2- (2-chlorophenoxy) -4-piperidyl group, 3- (3-chlorophenoxy) -5-piperidyl group, 4- (4-chlorophenoxy) -1-piperidyl group , 5- (2-bromophenoxy) -2-piperidyl group, 6- (3-bromophenoxy) -3-piperidyl group, 4- (4-bromophenoxy) -1-piperidyl group, 3- (2,3- Dichlorophenoxy) -2-piperidyl group, 4- (3,4-dichlorophenoxy) -3-piperidyl group, 3- (2,4-dichlorophenoxy) -4-piperidyl group, 2- (3,4,5- Trichlorophenoxy) -3-piperidyl group, 6- (2,4,6-trichlorophenoxy) -2-piperidyl group, 3- (2,3,4,5,6-pentafluorophenoxy) -1- Peridyl group, 4- (2-methylphenoxy) -1-piperidyl group, 5- (3-methylphenoxy) -2-piperidyl group, 6- (4-methylphenoxy) -3-piperidyl group, 4- (2- Ethylphenoxy) -1-piperidyl group, 2- (3-ethylphenoxy) -1-piperidyl group, 3- (4-ethylphenoxy) -2-piperidyl group, 4- (4-n-propylphenoxy) -3- Piperidyl group, 3- (4-tert-butylphenoxy) -4-piperidyl group, 2- (4-n-butylphenoxy) -3-piperidyl group, 1- (2-trifluoromethylphenoxy) -2-piperidyl group 2- (3-trifluoromethylphenoxy) -1-piperidyl group, 4- (4-trifluoromethylphenoxy) -1-piperidyl group, 1- (2-pentafluoro (Roethylphenoxy) -4-piperidyl group, 4- (3-pentafluoroethylphenoxy) -1-piperidyl group, 4- (2,3-dimethylphenoxy) -1-piperidyl group, 4- (3,4,5 -Trimethylphenoxy) -1-piperidyl group, 4- (4-n-pentylphenoxy) -1-piperidyl group, 4- (4-n-hexylphenoxy) -1-piperidyl group, 4- (2-methoxyphenoxy) -1-piperidyl group, 4- (3-methoxyphenoxy) -1-piperidyl group, 4- (4-methoxyphenoxy) -1-piperidyl group, 2- (2-ethoxyphenoxy) -3-piperidyl group, 3- (3-Ethoxyphenoxy) -4-piperidyl group, 4- (4-Ethoxyphenoxy) -3-piperidyl group, 3- (4-n-propoxyphenoxy) -2- Peridyl group, 2- (4-tert-butoxyphenoxy) -1-piperidyl group, 4- (4-n-butoxyphenoxy) -2-piperidyl group, 2- (2-trifluoromethoxyphenoxy) -3-piperidyl group 3- (3-trifluoromethoxyphenoxy) -4-piperidyl group, 4- (4-trifluoromethoxyphenoxy) -3-piperidyl group, 3- (2-pentafluoroethoxyphenoxy) -2-piperidyl group, 2 -(4-pentafluoroethoxyphenoxy) -1-piperidyl group, 4- (2,3-dimethoxyphenoxy) -14-piperidyl group, 4- (3,4,5-trimethoxyphenoxy) -1-piperidyl group, 4- (4-n-pentyloxyphenoxy) -1-piperidyl group, 4- (4-n-hexyloxyphenoxy) -1 Piperidyl group, 4-benzyl-1-piperidyl group, 2,4-dibenzyl-1-piperidyl group, 2,4,6-tribenzyl-1-piperidyl group, 2- (2-fluorobenzyl) -1-piperidyl group, 3- [2- (3-fluorophenyl) ethyl] -2-piperidyl group, 4- [1- (4-fluorophenyl) ethyl] -3-piperidyl group, 2- [3- (2-chlorophenyl) propyl] -4-piperidyl group, 3- [4- (3-chlorophenyl) butyl] -5-piperidyl group, 4- [5- (4-chlorophenyl) pentyl] -2-piperidyl group, 5- [6- (2- Bromophenyl) hexyl] -2-piperidyl group, 6- (3-bromobenzyl) -3-piperidyl group, 4- (4-bromobenzyl) -1-piperidyl group, 3- (2,3-dichlorobenzi L) -2-piperidyl group, 4- (3,4-dichlorobenzyl) -3-piperidyl group, 3- (2,4-dichlorobenzyl) -4-piperidyl group, 2- (3,4,5-trichloro) Benzyl) -3-piperidyl group, 6- (2,4,6-trichlorobenzyl) -2-piperidyl group, 3- (2,3,4,5,6-pentafluorobenzyl) -1-piperidyl group, 4 -(2-methylbenzyl) -1-piperidyl group, 5- [2- (3-methylphenyl) ethyl] -2-piperidyl group, 6- [3- (4-methylphenyl) propyl] -3-piperidyl group 1- [4- (2-ethylphenyl) butyl] -4-piperidyl group, 2- [5- (3-ethylphenyl) pentyl] -1-piperidyl group, 3- [6- (4-ethylphenyl) Hexyl] -2-piperidyl group, -(4-n-propylbenzyl) -3-piperidyl group, 3- (4-tert-butylbenzyl) -4-piperidyl group, 2- (4-n-butylbenzyl) -3-piperidyl group, 1- ( 2-trifluoromethylbenzyl) -2-piperidyl group, 2- (3-trifluoromethylbenzyl) -1-piperidyl group, 4- (4-trifluoromethylbenzyl) -1-piperidyl group, 1- (2- Pentafluoroethylbenzyl) -4-piperidyl group, 1- (3-pentafluoroethylbenzyl) -4-piperidyl group, 4- (2,3-dimethylbenzyl) -1-piperidyl group, 1- (3,4, 5-trimethylbenzyl) -4-piperidyl group, 1- (4-n-pentylbenzyl) -4-piperidyl group, 4- (4-n-hexylbenzyl) -1-piperidyl group, -(2-methoxybenzyl) -1-piperidyl group, 1- [2- (3-methoxyphenyl) ethyl] -4-piperidyl group, 1- [1- (4-methoxyphenyl) ethyl] -4-piperidyl group 2- [3- (2-ethoxyphenyl) propyl] -3-piperidyl group, 3- [4- (3-ethoxyphenyl) butyl] -4-piperidyl group, 4- [5- (4-ethoxyphenyl) Pentyl] -3-piperidyl group, 3- [6- (4-n-propoxyphenyl) hexyl] -2-piperidyl group, 2- (4-tert-butoxybenzyl) -1-piperidyl group, 1- (4- n-butoxybenzyl) -2-piperidyl group, 2- (2-trifluoromethoxybenzyl) -3-piperidyl group, 3- (3-trifluoromethoxybenzyl) -4-piperidyl group, 4- ( 4-trifluoromethoxybenzyl) -1-piperidyl group, 3- (2-pentafluoroethoxybenzyl) -2-piperidyl group, 2- (4-pentafluoroethoxybenzyl) -1-piperidyl group, 1- (2, 3-dimethoxybenzyl) -4-piperidyl group, 4- (3



, 4,5-trimethoxybenzyl) -1-piperidyl group, 4- (4-n-pentyloxybenzyl) -1-piperidyl group, 4- (4-n-hexyloxybenzyl) -1-piperidyl group, 4 -Benzyl-3-phenoxy-1-piperidyl group, 4-phenoxy-2-methylamino-1-piperidyl group, 4- (4-trifluoromethoxybenzylidene) -1-piperidyl group, 4- (4-chlorobenzylidene) -1-piperidyl group, 4- (4-trifluoromethylbenzylidene) -1-piperidyl group, 4- (3,4-dichlorobenzyloxy)-(1-, 2- or 3-) piperidyl group, 4- ( 4-methylbenzyloxy)-(1-, 2- or 3-) piperidyl group, 4- (4-trifluoromethoxybenzyloxy)-(1-, 2- or 3-) piperi 4- (4-methoxyphenyl)-(1-, 2- or 3-) piperidyl group, 4- (3,4-dichlorophenyl)-(1-, 2- or 3-) piperidyl group, 4- [(1- or 2-) naphthylmethyl]-(1-, 2- or 3-) piperidyl group, 4- (3,4-methylenedioxyphenyl)-(1-, 2- or 3-) piperidyl group , Piperidyl groups such as 4- (4-chlorobenzyloxy)-(1-, 2- or 3-) piperidyl groups [on piperidine rings, amino groups (on amino groups, phenyl groups [on phenyl rings] Is substituted with 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups. And a C1-6 alkyl group. 1 or 2 groups selected from the group may be substituted; a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1 1 to 5, preferably 1 to 3 groups selected from the group consisting of -6 alkoxy groups; a phenyl C1-6 alkyl group (on the phenyl ring having 1 to 4 carbon atoms) A group selected from the group consisting of a linear or branched C1-4 alkylenedioxy group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group 1 to 5, preferably 1 to 3 may be substituted); phenyl C1-6 alkoxy group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 alkyl; 1 to 5, preferably 1 to 3 groups selected from the group consisting of an alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; the phenyl group described above (phenyl ring) Above, 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group A naphthyl C1-6 alkyl group and a phenyl C1-6 alkylidene group whose alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms (on the phenyl ring, a halogen atom) 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group Conversion and selected from the group consisting of even may) have groups can be exemplified] may be in 1-3 substituents.

A quinolyloxy group (on the quinoline ring, (c-1) a halogen atom, (c-2) a phenoxy group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, At least one group selected from the group consisting of substituted C1-6 alkoxy groups may be substituted], (c-3) piperazinyl group [on the piperazine ring, a phenyl C1-6 alkyl group (phenyl On the ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. ), A phenyl group (on the phenyl ring, a phenoxy group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or At least one group selected from the group consisting of substituted C1-6 alkoxy groups may be substituted], halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups, and halogen-substituted or unsubstituted C1 -6 at least one group selected from the group consisting of alkoxy groups may be substituted) and a phenyl C2-6 alkenyl group [on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of an alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted], and at least one group selected from the group consisting of And (c-4) piperidyl group [on the piperidine ring, an amino group (on the amino group, a phenyl group [on the phenyl ring, a halogen atom, halogen At least one group selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] and a C1-6 alkyl group At least one group selected from the group may be substituted); a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1) -6 at least one group selected from the group consisting of alkoxy groups may be substituted; phenyl C1-6 alkyl group (on the phenyl ring, a C1-4 alkylenedioxy group, a halogen atom, a halogen atom) At least one selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group A phenyl C1-6 alkoxy group (on the phenyl ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group) A phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1 to C1). At least one group selected from the group consisting of 6 alkoxy groups may be substituted); a naphthyl C1-6 alkyl group and a phenyl C1-6 alkylidene group (on the phenyl ring, a halogen atom, halogen substitution or Selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group And at least one group selected from the group consisting of a group selected from the group consisting of: a group selected from the group consisting of: May be, for example, 2-quinolyloxy group, 3-quinolyloxy group, 4-quinolyloxy group, 5-quinolyloxy group, 6-quinolyloxy group, 7-quinolyloxy group, 8-quinolyloxy group, 4- (1-piperazinyl) 2-quinolyloxy group, 3- (2-piperazinyl) -4-quinolyloxy group, 4- (1-piperazinyl) -3-quinolyloxy group, 5- (1-piperazinyl) -4-quinolyloxy group, 6- (3 4-dibenzyl-1-piperazinyl) -5-quinolyloxy group, 7- (2,3,4-tribenzyl-1-piperazinyl) -6-quinolyloxy Group, 4- (4-benzyl-1-piperazinyl) -2-quinolyloxy group, 3- [4- (2-phenethyl) -1-piperazinyl] -2-quinolyloxy group, 4- [4- (3-phenylpropyl) ) -1-piperazinyl] -3-quinolyloxy group, 5- [4- (4-phenylbutyl) -1-piperazinyl] -4-quinolyloxy group, 6- [4- (5-phenylpentyl) -1-piperazinyl] -5-quinolyloxy group, 7- [4- (6-phenylhexyl) -1-piperazinyl] -6-quinolyloxy group, 8- [4- (2-fluorobenzyl) -1-piperazinyl] -7-quinolyloxy group, 2- [4- (3-fluorobenzyl) -1-piperazinyl] -8-quinolyloxy group, 3- [4- (4-fluorobenzyl) -1-piperazinyl] -2-ki Ryloxy group, 4- [4- (2-chlorobenzyl) -1-piperazinyl] -3-quinolyloxy group, 5- [4- (3-chlorobenzyl) -1-piperazinyl] -4-quinolyloxy group, 2- [ 4- (4-chlorobenzyl) -1-piperazinyl] -6-quinolyloxy group, 7- [4- (2,3-dichlorobenzyl) -1-piperazinyl] -6-quinolyloxy group, 8- [4- (2 , 4-Dichlorobenzyl) -1-piperazinyl] -7-quinolyloxy group, 2- [4- (3,4-dichlorobenzyl) -1-piperazinyl] -8-quinolyloxy group, 3- [4- (3,5 -Dichlorobenzyl) -1-piperazinyl] -2-quinolyloxy group, 4- [4- (3,4,5-trichlorobenzyl) -1-piperazinyl] -3-quinolyloxy group, 5- [ -(2,3,4,5,6-pentafluorobenzyl) -1-piperazinyl] -4-quinolyloxy group, 6- [4- (2-trifluoromethylbenzyl) -1-piperazinyl] -5-quinolyloxy group 7- [4- (3-trifluoromethylbenzyl) -1-piperazinyl] -6-quinolyloxy group, 2- [4- (4-trifluoromethylbenzyl) -1-piperazinyl] -6-quinolyloxy group, 2 -[4- (4-methylbenzyl) -1-piperazinyl] -8-quinolyloxy group, 3- [4- (3,4-dimethylbenzyl) -1-piperazinyl] -2-quinolyloxy group, 4- [4- (2,4,6-trimethylbenzyl) -1-piperazinyl] -3-quinolyloxy group, 5- [4- (2-pentafluoroethylbenzyl) -1-piperazinyl ] -4-quinolyloxy group, 6- [4- (3-pentafluoroethylbenzyl) -1-piperazinyl] -5-quinolyloxy group, 7- [4- (4-pentafluoroethylbenzyl) -1-piperazinyl]- 6-quinolyloxy group, 2- [4- (4-trifluoromethoxybenzyl) -1-piperazinyl] -6-quinolyloxy group, 2- [4- (3-trifluoromethoxybenzyl) -1-piperazinyl] -8- Quinolyloxy group, 3- [4- (4-trifluoromethoxybenzyl) -1-piperazinyl] -2-quinolyloxy group, 4- [4- (4-methoxybenzyl) -1-piperazinyl] -3-quinolyloxy group, 5 -[4- (3,4-dimethoxybenzyl) -1-piperazinyl] -4-quinolyloxy group, 6- [4- (2,4,6-tri Toxibenzyl) -1-piperazinyl] -5-quinolyloxy group, 7- [4- (2-pentafluoroethoxybenzyl) -1-piperazinyl] -6-quinolyloxy group, 8- [4- (3-pentafluoroethoxybenzyl) ) -1-piperazinyl] -2-quinolyloxy group, 3- [4- (4-pentafluoroethoxybenzyl) -1-piperazinyl] -2-quinolyloxy group, 4- {4- [2- (4-trifluoromethoxy) Phenyl) ethyl] -1-piperazinyl} -3-quinolyloxy group, 5- {4- [3- (4-trifluoromethoxyphenyl) propyl] -1-piperazinyl] -4-quinolyloxy group, 6- {4- [ 4- (4-trifluoromethoxyphenyl) butyl] -1-piperazinyl} -5-quinolyloxy group, 7- {4- [5 (4-trifluoromethoxyphenyl) pentyl] -1-piperazinyl} -6-quinolyloxy group, 8- {4- [6- (4-trifluoromethoxyphenyl) hexyl] -1-piperazinyl} -7-quinolyloxy group, 2- {4- [2- (4-trifluoromethylphenyl) ethyl] -1-piperazinyl} -8-quinolyloxy group, 3- {4- [3- (4-trifluoromethylphenyl) propyl] -1- Piperazinyl} -2-quinolyloxy group, 4- {4- [4- (4-trifluoromethylphenyl) butyl] -1-piperazinyl} -2-quinolyloxy group, 5- {4- [5- (4-trifluoro) Methylphenyl) pentyl] -1-piperazinyl} -2-quinolyloxy group, 6- {4- [6- (4-trifluoromethylphenyl) hexyl ] -1-piperazinyl} -2-quinolyloxy group, 3- (2-piperidyl) -2-quinolyloxy group, 4- (3-piperidyl) -3-quinolyloxy group, 5- (4-piperidyl) -4-quinolyloxy group , 6- (2,4-diamino-1-piperidyl) -5-quinolyloxy group, 7- (2,4,6-triamino-1-piperidyl) -6-quinolyloxy group, 8- (4-amino-1- Piperidyl) -7-quinolyloxy group, 2- (4-amino-1-piperidyl) -8-quinolyloxy group, 3- (4-amino-1-piperidyl) -2-quinolyloxy group, 4- (4-methylamino- 1-piperidyl) -3-quinolyloxy group, 5- (4-ethylamino-1-piperidyl) -4-quinolyloxy group, 6- (4-n-propylamino-1-piperidyl) 5-quinolyloxy group, 7- (4-dimethylamino-1-piperidyl) -6-quinolyloxy group, 8- (4-diethylamino-1-piperidyl) -7-quinolyloxy group, 2- (4-di-n-propyl) Amino-1-piperidyl) -8-quinolyloxy group, 3- (4-phenylamino-1-piperidyl) -2-quinolyloxy group, 4- [4- (N-phenyl-N-methylamino) -1-piperidyl] -3-quinolyloxy group, 5- [4- (2-fluorophenylamino) -1-piperidyl] -4-quinolyloxy group, 6- [4- (3-fluorophenylamino) -1-piperidyl] -5-quinolyloxy Group, 7- [4- (4-fluorophenylamino) -1-piperidyl] -6-quinolyloxy group, 8- [4- (2-chlorophenylamino) 1-piperidyl] -7-quinolyloxy group, 2- [4- (3-chlorophenylamino) -1-piperidyl] -8-quinolyloxy group, 3- [4- (4-chlorophenylamino) -1-piperidyl] -2 -Quinolyloxy group, 4- [4- (2,3-dichlorophenylamino) -1-piperidyl] -3-quinolyloxy group, 5- [4- (2,4,6-trifluorophenylamino) -1-piperidyl] -4-quinolyloxy group, 6- [4- (2,4-dichlorophenylamino) -1-piperidyl] -5-quinolyloxy group, 7- [4- (3,4-dichlorophenylamino) -1-piperidyl] -6 -Quinolyloxy group, 8- [4- (3,5-dichlorophenylamino) -1-piperidyl] -7-quinolyloxy group, 2- [4- (2,3,4,5, 6-pentafluorophenylamino) -1-piperidyl] -8-quinolyloxy group, 3- [4- (2-trifluoromethylphenylamino) -1-piperidyl] -2-quinolyloxy group, 4- [4- (2 -Methylphenylamino) -1-piperidyl] -3-quinolyloxy group, 5- [4- (2,3-dimethylphenylamino) -1-piperidyl] -4-quinolyloxy group, 6- [4- (2-tri Fluoromethylphenylamino) -1-piperidyl] -5-quinolyloxy group, 7- [4- (2,4,6-trimethylphenylamino) -1-piperidyl] -6-quinolyloxy group, 8- [4- (4 -Trifluoromethylphenylamino) -1-piperidyl] -7-quinolyloxy group, 2- [4- (2-pentafluoroethylphenylamino) -1 Piperidyl] -8-quinolyloxy group, 3- [4- (3-pentafluoroethylphenylamino) -1-piperidyl] -2-quinolyloxy group, 4- [4- (4-pentafluoroethylphenylamino) -1- Piperidyl]}-3-quinolyloxy group, 5- [



4- (2-trifluoromethoxyphenylamino) -1-piperidyl] -4-quinolyloxy group, 6- [4- (2-methoxyphenylamino) -1-piperidyl] -5-quinolyloxy group, 7- [4- (2,3-dimethoxyphenylamino) -1-piperidyl] -6-quinolyloxy group, 8- [4- (2,4,6-trimethoxyphenylamino) -1-piperidyl] -7-quinolyloxy group, 2- {4- [N-methyl-N- (2,4,6-trimethoxyphenylamino)]-1-piperidyl} -8-quinolyloxy group, 3- {4- [N-methyl-N- (3,4) -Dimethylphenylamino)]-1-piperidyl} -2-quinolyloxy group, 4- [4- (3-trifluoromethoxyphenylamino) -1-piperidyl] -2-quinolyloxy group, -[4- (4-trifluoromethoxyphenylamino) -1-piperidyl] -2-quinolyloxy group, 6- [4- (2-pentafluoroethoxyphenylamino) -1-piperidyl] -2-quinolyloxy group, 7 -[4- (3-pentafluoroethoxyphenylamino) -1-piperidyl] -2-quinolyloxy group, 8- [4- (4-pentafluoroethoxyphenylamino) -1-piperidyl] -2-quinolyloxy group, 2 -[4- (2-fluorophenylamino) -1-piperidyl] -3-quinolyloxy group, 3- [4- (3-fluorophenylamino) -1-piperidyl] -2-quinolyloxy group, 4- [4- (4-Fluorophenylamino) -1-piperidyl] -2-quinolyloxy group, 2- {4- [N-ethyl-N- (4-chloro Phenyl) amino] -1-piperidyl} -6-quinolyloxy group, 2,4-di (1-piperazinyl) -6-quinolyloxy group, 3- (1-piperidyl) -4- (1-piperazinyl) -2-quinolyloxy group Group, 2,4,6-tri (1-piperidyl) -3-quinolyloxy group, 5-chloro-8-quinolyloxy group, 2- (4-trifluoromethoxyphenoxy) -6-quinolyloxy group, 2- [4- (4-trifluoromethoxybenzylidene) -1-piperidyl] -6-quinolyloxy group, 2- [4- (4-chlorobenzylidene) -1-piperidyl] -6-quinolyloxy group, 2- [4- (4-tri Fluoromethylbenzylidene) -1-piperidyl] -6-quinolyloxy group, 2- (4-benzyl-1-piperidyl) -4-quinolyloxy group, 2 -(3,4-dibenzyl-1-piperidyl) -4-quinolyloxy group, 5- (2,3,4-tribenzyl-1-piperidyl) -2-quinolyloxy group, 4- [4- (2-phenethyl)- 1-piperidyl] -2-quinolyloxy group, 4- [4- (3-phenylpropyl) -1-piperidyl] -5-quinolyloxy group, 4- [4- (4-phenylbutyl) -1-piperidyl] -6 -Quinolyloxy group, 4- [4- (5-phenylpentyl) -1-piperidyl] -7-quinolyloxy group, 2- [4- (6-phenylhexyl) -1-piperidyl] -4-quinolyloxy group, 4- [4- (2-fluorobenzyl) -1-piperidyl] -2-quinolyloxy group, 2- [4- (3-fluorobenzyl) -1-piperidyl] -4-quinolyloxy group, 2- [ -(4-fluorobenzyl) -1-piperidyl] -5-quinolyloxy group, 2- [4- (2-chlorobenzyl) -1-piperidyl] -6-quinolyloxy group, 2- [4- (3-chlorobenzyl) ) -1-Piperidyl] -7-quinolyloxy group, 5- [4- (4-chlorobenzyl) -1-piperidyl] -4-quinolyloxy group, 6- [4- (2,3-dichlorobenzyl) -1- Piperidyl] -4-quinolyloxy group, 7- [4- (2,4-dichlorobenzyl) -1-piperidyl] -8-quinolyloxy group, 2- [4- (3,4-dichlorobenzyl) -1-piperidyl] -8-quinolyloxy group, 4- [4- (3,5-dichlorobenzyl) -1-piperidyl] -2-quinolyloxy group, 4- [4- (3,4,5-trichlorobenzyl) -1-pipe Dil] -5-quinolyloxy group, 4- [4- (2,3,4,5,6-pentafluorobenzyl) -1-piperidyl] -2-quinolyloxy group, 4- [4- (2-trifluoromethyl) Benzyl) -1-piperidyl] -6-quinolyloxy group, 4- [4- (3-trifluoromethylbenzyl) -1-piperidyl] -7-quinolyloxy group, 2- [4- (4-trifluoromethylbenzyl) -1-piperidyl] -8-quinolyloxy group, 5- [4- (4-methylbenzyl) -1-piperidyl] -4-quinolyloxy group, 6- [4- (3,4-dimethylbenzyl) -1-piperidyl ] -4-quinolyloxy group, 8- [4- (2,4,6-trimethylbenzyl) -1-piperidyl] -4-quinolyloxy group, 3- [4- (2-pentafluoroethylben) Di) -1-piperidyl] -2-quinolyloxy group, 8- [4- (3-pentafluoroethylbenzyl) -1-piperidyl] -5-quinolyloxy group, 4- [4- (4-pentafluoroethylbenzyl) -1-piperidyl] -6-quinolyloxy group, 4- [4- (2-trifluoromethoxybenzyl) -1-piperidyl] -7-quinolyloxy group, 5- [4- (3-trifluoromethoxybenzyl) -1 -Piperidyl] -4-quinolyloxy group, 6- [4- (4-trifluoromethoxybenzyl) -1-piperidyl] -5-quinolyloxy group, 7- [4- (4-methoxybenzyl) -1-piperidyl]- 5-quinolyloxy group, 6- [4- (3,4-dimethoxybenzyl) -1-piperidyl] -4-quinolyloxy group, 7- [4- (2,4,4) -Trimethoxybenzyl) -1-piperidyl] -4-quinolyloxy group, 5- [4- (2-pentafluoroethoxybenzyl) -1-piperidyl] -4-quinolyloxy group, 4- [4- (3-pentafluoro) Ethoxybenzyl) -1-piperidyl] -2-quinolyloxy group, 6- [4- (4-pentafluoroethoxybenzyl) -1-piperidyl] -4-quinolyloxy group, 4- {4- [2- (4-tri Fluoromethoxyphenyl) ethyl] -1-piperidyl} -2-quinolyloxy group, 4- {4- [3- (4-trifluoromethoxyphenyl) propyl] -1-piperidyl} -2-quinolyloxy group, 4- {4 -[4- (4-trifluoromethoxyphenyl) butyl] -1-piperidyl} -2-quinolyloxy group, 4- {4- [5- (4 Trifluoromethoxyphenyl) pentyl] -1-piperidyl} -3-quinolyloxy group, 4- {4- [6- (4-trifluoromethoxyphenyl) hexyl] -1-piperidyl} -3-quinolyloxy group, 4- { 4- [2- (4-trifluoromethylphenyl) ethyl] -1-piperidyl} -2-quinolyloxy group, 5- {4- [3- (4-trifluoromethylphenyl) propyl] -1-piperidyl}- 2-quinolyloxy group, 6- {4- [4- (4-trifluoromethylphenyl) butyl] -1-piperidyl} -2-quinolyloxy group, 7- {4- [5- (4-trifluoromethylphenyl) Pentyl] -2-piperidyl} -2-quinolyloxy group, 5- {4- [6- (4-trifluoromethylphenyl) hexyl] -1-piperidyl } -2-quinolyloxy group, 2- (4-phenoxy-1-piperidyl) -4-quinolyloxy group, 2- (3,4-diphenoxy-1-piperidyl) -4-quinolyloxy group, 5- (2,3,3) 4-triphenoxy-1-piperidyl) -2-quinolyloxy group, 4- [4- (2-fluorophenoxy) -1-piperidyl] -2-quinolyloxy group, 2- [4- (3-fluorophenoxy) -1 -Piperidyl] -4-quinolyloxy group, 2- [4- (4-fluorophenoxy) -1-piperazinyl] -5-quinolyloxy group, 2- [4- (2-chlorophenoxy) -1-piperidyl] -6 Quinolyloxy group, 2- [4- (3-chlorophenoxy) -1-piperidyl] -7-quinolyloxy group, 5- [4- (4-chlorophenoxy) -1-piperidi ] -4-quinolyloxy group, 6- [4- (2,3-dichlorophenoxy) -1-piperidyl] -4-quinolyloxy group, 7- [4- (2,4-dichlorophenoxy) -1-piperidyl]- 4-quinolyloxy group, 2- [4- (3,4-dichlorophenoxy) -1-piperidyl] -8-quinolyloxy group, 4- [4- (3,5-dichlorophenoxy) -1-piperidyl] -2- Quinolyloxy group, 4- [4- (3,4,5-trichlorophenoxy) -1-piperidyl] -5-quinolyloxy group, 4- [4- (2,3,4,5,6-pentafluorophenoxy)- 1-piperidyl] -2-quinolyloxy group, 4- [4- (2-trifluoromethylphenoxy) -1-piperidyl] -6-quinolyloxy group, 4- [4- (3-trifluoromethyl) Enoxy) -1-piperidyl] -7-quinolyloxy group, 2- [4- (4-trifluoromethylphenoxy) -1-piperidyl] -4-quinolyloxy group, 5- [4- (4-methylphenoxy) -1 -Piperidyl] -4-quinolyloxy group, 6- [4- (3,4-dimethylphenoxy) -1-piperidyl] -4-quinolyloxy group, 7- [4- (2,4,6-trimethylphenoxy) -1 -Piperidyl] -4-quinolyloxy group, 4- [4- (2-pentafluoroethylphenoxy) -1-piperidyl] -2-quinolyloxy group, 4- [4- (3-pentafluoroethylphenoxy) -1-piperidyl ] -5-quinolyloxy group, 4- [4- (4-pentafluoroethylphenoxy) -1-piperidyl] -6-quinolyloxy group, 4- [4- (2-trifluoromethoxyphenoxy) -1-piperidyl] -7-quinolyloxy group, 5- [4- (3-trifluoromethoxyphenoxy) -1-piperidyl] -4-quinolyloxy group, 6- [4- (4 -Trifluoromethoxyphenoxy) -1-piperidyl] -5-quinolyloxy group, 7- [4- (4-methoxyphenoxy) -1-piperidyl] -5-quinolyloxy group, 6- [4- (3,4-dimethoxy) Phenoxy) -1-piperidyl] -4-quinolyloxy group, 8- [4- (2,4,6-trimethoxyphenoxy) -1-piperidyl] -4-quinolyloxy group, 5- [4- (2-pentafluoro) Ethoxyphenoxy) -1-piperidyl] -4-quinolyloxy group, 4- [4- (3-pentafluoroethoxyphenoxy) -1-piperyl Ru] -2-quinolyloxy group, 6- [4- (4-pentafluoroethoxyphenoxy) -1-piperidyl] -4-quinolyloxy group, 2,5,6-triphenoxy-7-quinolyloxy group, 4,5, 6-trichloro-2-quinolyloxy group, 2-phenoxy-6-bromo-5-quinolyloxy group, 2- (2,3-dimethylphenoxy) -5-quinolyloxy group, 2- (3,4,5-trimethylphenoxy) -6-quinolyloxy group, 2- (2,3-dimethoxyphenoxy) -7-quinolyloxy group, 2- (3,4,5-trimethoxyphenoxy) -8-quinolyloxy group, 2- (2,3,4, 5,6-pentafluorophenoxy) -6-quinolyloxy group, 2- (2-methylphenoxy) -4-quinolyloxy group, 2- (3-methylpheno) C) -3-quinolyloxy group, 3- (4-methylphenoxy) -2-quinolyloxy group, 4- (2-methoxyphenoxy) -3-quinolyloxy group, 5- (3-methoxyphenoxy) -4-quinolyloxy group, 6- (4-methoxyphenoxy) -5-quinolyloxy group, 7- (2-fluorophenoxy) -6-quinolyloxy group, 8- (3-fluorophenoxy) -7-quinolyloxy group, 2- (4-fluorophenoxy) -5-quinolyloxy group, 3- (2-chlorophenoxy) -2-quinolyloxy group, 4- (3-chlorophenoxy) -6-quinolyloxy group, 5- (4-chlorophenoxy) -2-quinolyloxy group, 6- (2-bromophenoxy) -3-quinolyloxy group, 7- (3-bromophenoxy) -4-quinolyloxy group, 8 -(4-bromophenoxy) -2-quinolyloxy group, 2- (2,3-dichlorophenoxy) -6-quinolyloxy group, 3- (3,4-dichlorophenoxy) -7-quinolyloxy group, 4- (2, 4-dichlorophenoxy) -5-quinolyloxy group, 2- (3,4,5-



Trichlorophenoxy) -6-quinolyloxy group, 2- (2,4,6-trichlorophenoxy) -5-quinolyloxy group, 2- (3-trifluoromethylphenoxy) 7-quinolyloxy group, 2- {4- [3- (4-trifluoromethylphenyl) -2-propenyl]-(1-, 2- or 3-) piperazinyl}-(3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group, 2 -[4- (4-methoxyphenyl)-(1-, 2- or 3-) piperazinyl]-(3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group, 2- [4 -(3,4-dimethylphenyl)-(1-, 2- or 3-) piperazinyl]-(3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group, 2- [4- (4-Fluorophenyl)-(1-, 2- or 3-) pi Razinyl]-(3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group, 2- [4- (4-trifluoromethylphenyl)-(1-, 2- or 3-) piperazinyl ]-(3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group, 2- [4- (4-methylphenyl)-(1-, 2- or 3-) piperazinyl]-( 3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group, 2- [4- (3,4-dichlorophenyl)-(1-, 2- or 3-) piperazinyl]-(3- , 4-, 5-, 6-, 7- or 8-) quinolyloxy group, 2- [4- (4-trifluoromethoxyphenyl)-(1-, 2- or 3-) piperazinyl]-(3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy, 2- {4- [4- (4-chlorophenoxy) f Nyl]-(1-, 2- or 3-) piperazinyl}-(3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group, 2- [4- (3,4-dichlorobenzyl) Oxy)-(1-, 2- or 3-) piperidyl]-(3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group, 2- [4- (4-methylbenzyloxy) -(1-, 2- or 3-) piperidyl]-(3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group, 2- [4- (4-trifluoromethoxybenzyloxy) -(1-, 2- or 3-) piperidyl]-(3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group, 2- [4- (4-methoxyphenyl)-(1 -, 2- or 3-) piperidyl]-(3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group, 2- [4- (3,4-dichlorophenyl)-(1-, 2- or 3-) piperidyl]-(3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group, 2- {4-[( 1- or 2-) naphthylmethyl]-(1-, 2- or 3-) piperidyl}-(3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group, 2- [4- (3,4-methylenedioxyphenyl)-(1-, 2- or 3-) piperidyl]-(3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group, 2- [4 A quinolyloxy group (quinoline ring) such as-(4-chlorobenzyloxy)-(1-, 2- or 3-) piperidyl]-(3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group (C-1) halogen atom, (c-2) phenoxy group (on the phenyl ring, 1 to 5, preferably 1 to 3 groups selected from the group consisting of a substituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), (c- 3) Piperazinyl group [on the piperazine ring, a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group 1 to 5, preferably 1 to 3 groups selected from the group consisting of: a phenyl group (on the phenyl ring, a phenoxy group [on the phenyl ring, a halogen atom, a halogen 1 to 5, preferably 1 to 3 groups selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group are substituted. And a phenylalkenyl group composed of 2 to 6 carbon atoms and having at least 1 to 3 double bonds, and includes both trans and cis isomers. 1 to 5, preferably 1 to 3 groups selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] 1 to 3 groups selected from the group may be substituted] and (c-4) piperidyl group [on the piperidine ring is an amino group (on the amino group is a phenyl group [phenyl ring Is substituted with 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups And 1 to 2 groups selected from the group consisting of C1-6 alkyl groups may be substituted), a phenoxy group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted) 1 to 5, preferably 1 to 3 groups selected from the group consisting of a C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group), phenyl C1-6 An alkyl group (on the phenyl ring, a linear or branched alkylenedioxy group having 1 to 4 carbon atoms, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or 1 to 5, preferably 1 to 3 groups selected from the group consisting of substituted C1-6 alkoxy groups), and the alkoxy moiety is a straight chain or branched chain having 1 to 6 carbon atoms A phenyl C1-6 alkoxy group, which is an alkoxy group (on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) 1 to 5, preferably 1 to 3 groups), a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted group). 1 to 5 groups, preferably 1 to 3 groups selected from the group consisting of substituted C1-6 alkoxy groups may be substituted, and the alkyl moiety is a straight chain or branched chain having 1 to 6 carbon atoms. State A naphthyl C1-6 alkyl group and a phenyl C1-6 alkylidene group which are alkyl groups (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) A group selected from the group consisting of 1 to 5 groups, preferably 1 to 3 groups selected from the group consisting of 1 to 3 groups may be substituted]. 1 to 3 groups selected more may be substituted).

  A phenyl C1-6 alkoxy substituted C1-6 alkyl group (on the phenyl ring, selected from the group consisting of a halogen atom, a halogen substituted or unsubstituted C1-6 alkyl group and a halogen substituted or unsubstituted C1-6 alkoxy group; Is a group consisting of a halogen atom as defined above, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. A group selected from 1 to 5, preferably 1 to 3 phenyl C1-6 alkoxy groups and C1-6 alkyl groups which may be substituted, such as a benzyloxymethyl group 2-phenylethoxymethyl group, 3-phenylpropoxymethyl group, 2-phenylpropoxymethyl group, 4-phenylbutoxymethyl Group, 5-phenylpentoxymethyl group, 4-phenylpentoxymethyl group, 6-phenylhexyloxymethyl group, 2-fluorobenzyloxymethyl group, 4-fluorobenzyloxymethyl group, 4-chlorobenzyloxymethyl group, 3-chlorobenzyloxymethyl group, 2-chlorobenzyloxymethyl group, 3,5-dichlorobenzyloxymethyl group, 3,4-dichlorobenzyloxymethyl group, 2- (3-fluorobenzyloxy) ethyl group, 1- (4-fluorobenzyloxy) ethyl group, 3- [2- (2-fluorophenyl) ethoxy] propyl group, 4- [2- (3-fluorophenyl) ethoxy] butyl group, 5- [2- (4- Fluorophenyl) ethoxy] pentyl group, 6- (2-chlorobenzyloxy) hexyl group, 3-chloro Benzyloxymethyl group, 2- (4-chlorobenzyloxy) ethyl group, 1- (2-fluoro-4-bromobenzyloxy) ethyl group, 3- (4-chloro-3-fluorobenzyloxy) propyl group, 4 -(2,3,4-trichlorobenzyloxy) butyl group, 5- (3,4,5-trifluorobenzyloxy) pentyl group, 6- (2,3,4,5,6-pentafluorobenzyloxy) Hexyl group, 2,4,6-trichlorobenzyloxymethyl group, 2- (4-isopropylbenzyloxy) ethyl group, 1- (4-n-butylbenzyloxy) ethyl group, 3- (4-methylbenzyloxy) Propyl group, 4- (2-methylbenzyloxy) butyl group, 5- (3-methylbenzyloxy) pentyl group, 6- (2,4-dimethylbenzyloxy) )] Hexyl group, 2,3-dimethylbenzyloxymethyl group, 4-methylbenzyloxymethyl group, 4-ethylbenzyloxymethyl group, 3,5-dimethylbenzyloxymethyl group, 4-isopropylbenzyloxymethyl group, 3 -Trifluoromethylbenzyloxymethyl group, 4-trifluoromethylbenzyloxymethyl group, 2-trifluoromethylbenzyloxymethyl group, 2- (2,6-dimethylbenzyloxy) ethyl group, 1- (3,5- Dimethylbenzyloxy) ethyl group, 3- (2,5-dimethylbenzyloxy) propyl group, 4- (2,4,6-trimethylbenzyloxy) butyl group, 5- (3,5-ditrifluoromethylbenzyloxy) Pentyl group, 6- (4-isopropoxybenzyloxy) hexyl group, 4-n-butyl Xibenzyloxymethyl group, 4-trifluoromethoxybenzyloxymethyl group, 2-trifluoromethoxybenzyloxymethyl group, 3-trifluoromethoxybenzyloxymethyl group, 3-methoxybenzyloxymethyl group, 2- (4-methoxy Benzyloxy) ethyl group, 1- (2-methoxybenzyloxy) ethyl group, 3- (3-methoxybenzyloxy) propyl group, 4- (2,4-dimethoxybenzyloxy) butyl group, 5- (2,3 -Dimethoxybenzyloxy) pentyl group, 6- (2,6-dimethoxybenzyloxy) hexyl group, 3,5-dimethoxybenzyloxymethyl group, 2- (2,5-dimethoxybenzyloxy) ethyl group, 1- (2 , 4,6-Trimethoxybenzyloxy) ethyl group, 3- (3,5-ditri Fluoromethoxybenzyloxy) propyl group, 4- (2-isopropoxybenzyloxy) butyl group, 5- (3-chloro-4-methoxybenzyloxy) pentyl group, 6- (2-chloro-4-trifluoromethoxy) Benzyloxy) hexyl group, 3-methyl-4-fluorobenzyloxymethyl group, 2- (4-bromo-3-trifluoromethylbenzyloxy) ethyl group, 1- [2- (2-chlorophenyl) ethoxy] methyl group , 3- [2- (3-chlorophenyl) ethoxy] propyl group, 4- [2- (4-chlorophenyl) ethoxy] butyl group, 5- [2-trifluoromethylbenzyloxy] pentyl group, 6- (3- Trifluoromethylbenzyloxy) hexyl group, 4-trifluoromethylbenzyloxymethyl group, 2- (2-trifluoro) Fluoromethoxybenzyloxy) ethyl group, 1- (3-trifluoromethoxybenzyloxy) ethyl group, 3- (4-trifluoromethoxybenzyloxy) propyl group, 4- [2- (2-trifluoromethylphenyl) Ethoxy] butyl group, 5- [2- (3-trifluoromethylphenyl) ethoxy] pentyl group, 6- [2- (4-trifluoromethylphenyl) ethoxy] hexyl group, [2- (2-trifluoromethoxy) Phenyl) ethoxy] methyl group, 2- [2- (3-trifluoromethoxyphenyl) ethoxy] ethyl group, 1- [2- (4-trifluoromethoxyphenyl) ethoxy] ethyl group, 3- [3- (2 -Trifluoromethylphenyl) propoxy] propyl group, 4- [3- (3-trifluoromethylphenyl) propoxy Butyl group, 5- [3- (4-trifluoromethylphenyl) propoxy] pentyl group, 6- [3- (2-trifluoromethylphenyl) propoxy] hexyl group, [3- (3-trifluoromethoxyphenyl) Propoxy] methyl group, 2- [3- (4-trifluoromethoxyphenyl) propoxy] ethyl group, 1- [4- (3-trifluoromethylphenyl) butoxy] ethyl group, 3- [5- (4-tri Fluoromethylphenyl) pentoxy] butyl group, 4- [4- (4-trifluoromethylphenyl) pentoxy] butyl group, 5- [4- (4-trifluoromethoxyphenyl) pentoxy] pentyl group, 6- [6- (3-trifluoromethylphenyl) hexyloxy] hexyl group, [6- (4-trifluoromethylphenyl) hexyl Carboxymethyl] methyl group, and 2- [6- (4-trifluoromethoxyphenyl) hexyloxy] ethyl group or the like.

A piperidyl group [on the piperidine ring is selected from the group consisting of a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; A phenyl C1-6 alkoxy-substituted C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted group). Or at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted), a phenoxy C1-6 alkyl group (on the phenyl ring, a halogen atom, halogen-substituted or A small number of groups selected from the group consisting of substituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups; At least one kind may be substituted) and a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6) At least one group selected from the group consisting of a group selected from the group consisting of alkoxy groups may be substituted)], for example, 1-piperidyl Group, 4-piperidyl group, 2-piperidyl group, 3-piperidyl group, 4-phenoxy-1-piperidyl group, 2,4-diphenoxy-1-piperidyl group, 2,4,6-triphenoxy-1-piperidyl group 2- (2-fluorophenoxy) -1-piperidyl group, 3- (3-fluorophenoxy) -2-piperidyl group, 4- (4-fluorophenoxy) -3- Peridyl group, 2- (2-chlorophenoxy) -4-piperidyl group, 3- (3-chlorophenoxy) -5-piperidyl group, 4- (4-chlorophenoxy) -2-piperidyl group, 5- (2- Bromophenoxy) -2-piperidyl group, 6- (3-bromophenoxy) -3-piperidyl group, 4- (4-bromophenoxy) -1-piperidyl group, 3- (2,3-dichlorophenoxy) -2- Piperidyl group, 4- (3,4-dichlorophenoxy) -3-piperidyl group, 3- (2,4-dichlorophenoxy) -4-piperidyl group, 2- (3,4,5-trichlorophenoxy) -3- Piperidyl group, 6- (2,4,6-trichlorophenoxy) -2-piperidyl group, 3- (2,3,4,5,6-pentafluorophenoxy) -1-piperidyl group, 4- (2-me Tilphenoxy) -1-piperidyl group, 5- (3-methylphenoxy) -2-piperidyl group, 6- (4-methylphenoxy) -3-piperidyl group, 3- (2-ethylphenoxy) -4-piperidyl group 2- (3-ethylciphenoxy) -1-piperidyl group, 3- (4-ethylphenoxy) -2-piperidyl group, 4- (4-n-propylphenoxy) -3-piperidyl group, 3- (4 -Tert-butylphenoxy) -4-piperidyl group, 2- (4-n-butylphenoxy) -3-piperidyl group, 4- (2-trifluoromethylphenoxy) -2-piperidyl group, 2- (3-tri Fluoromethylphenoxy) -1-piperidyl group, 3- (4-trifluoromethylphenoxy) -1-piperidyl group, 1- (2-pentafluoroethylphenoxy)- -Piperidyl group, 1- (3-pentafluoroethylphenoxy) -4-piperidyl group, 4- (2,3-dimethylphenoxy) -1-piperidyl group, 3- (3,4,5-trimethylphenoxy) -4 -Piperidyl group, 1- (4-n-pentylphenoxy) -4-piperidyl group, 4- (4-n-hexylphenoxy) -1-piperidyl group, 4- (2-methoxyphenoxy) -1-piperidyl group, 1- (3-methoxyphenoxy) -4-piperidyl group, 3- (4-methoxyphenoxy) -4-piperidyl group, 2- (2-ethoxyphenoxy) -3-piperidyl group, 3- (3-ethoxyphenoxy) -4-piperidyl group, 4- (4-ethoxyphenoxy) -3-piperidyl group, 3- (4-n-propoxyphenoxy) -2-piperidyl group, 2- (4 tert-butoxyphenoxy) -1-piperidyl group, 4- (4-n-butoxyphenoxy) -2-piperidyl group, 2- (2-trifluoromethoxyphenoxy) -3-piperidyl group, 3- (3-trifluoro Methoxyphenoxy) -4-piperidyl group, 4- (4-trifluoromethoxyphenoxy) -3-piperidyl group, 3- (2-pentafluoroethoxyphenoxy) -2-piperidyl group, 2- (4-pentafluoroethoxyphenoxy) ) -1-piperidyl group, 3- (2,3-dimethoxyphenoxy) -4-piperidyl group, 4- (3,4,5-trimethoxyphenoxy) -1-piperidyl group, 4- (4-n-pentyl) Oxyphenoxy) -1-piperidyl group, 4- (4-n-hexyloxyphenoxy) -1-piperidyl group, 4-benzyl Ru-1-piperidyl group, 2,4-dibenzyl-1-piperidyl group, 2,4,6-tribenzyl-1-piperidyl group, 2- (2-fluorobenzyl) -1-piperidyl group, 3- [2- (3-Fluorophenyl) ethyl] -2-piperidyl group, 4- [1- (4-fluorophenyl) ethyl] -3-piperidyl group, 2- [3- (2-chlorophenyl) propyl] -4-piperidyl group 3- [4- (3-chlorophenyl) butyl] -5-piperidyl group, 4- [5- (4-chlorophenyl) pentyl] -2-piperidyl group, 5-([6- (2-bromophenyl) hexyl] ] -2-piperidyl group, 6- (3-bromobenzyl) -3-piperidyl group, 4- (4-bromobenzyl) -1-piperidyl group, 3- (2,3-dichlorobenzyl) -2-piperidyl group 4- (3,4-dichlorobenzyl) -3-piperidyl group, 3- (2,4-dichlorobenzyl) -4-piperidyl group, 2- (3,4,5-trichlorobenzyl) -3-piperidyl group, 6- (2,4,6-trichlorobenzyl) -2-piperidyl group, 3- (2,3,4,5,6-pentafluorobenzyl) -1-piperidyl group, 4- (2-methylbenzyl)- 1-piperidyl group, 5- [2- (3-methylphenyl) ethyl] -2-piperidyl group, 6- [3- (4-methylphenyl) propyl] -3-piperidyl group, 1- [4- (2 -Ethylphenyl) butyl] -4-piperidyl group, 2- [5- (3-ethylphenyl) pentyl] -1-piperidyl group, 3- [6- (4-ethylphenyl) hexyl] -2-piperidyl group, 4- (4-n-propyl) Ndyl) -3-piperidyl group, 3- (4-tert-butylbenzyl) -4-piperidyl group, 2- (4-n-butylbenzyl) -3-piperidyl group, 1- (2-trifluoromethylbenzyl) 2-piperidyl group, 2- (3-trifluoromethylbenzyl) -1-piperidyl group, 4- (4-trifluoromethylbenzyl) -1-piperidyl group, 1- (2-pentafluoroethylbenzyl) -4 -Piperidyl group, 1- (3-pentafluoroethylbenzyl) -4-piperidyl group, 4- (2,3-dimethylbenzyl) -1-piperidyl group, 1- (3,4,5-trimethylbenzyl) -4 -Piperidyl group, 1- (4-n-pentylbenzyl) -4-piperidyl group, 4- (4-n-hexylbenzyl) -1-piperidyl group, 4- (2-methoxybenzyl) L) -1-piperidyl group, 1- [2- (3-methoxyphenyl) ethyl] -4-piperidyl group, 1- [1- (4-methoxyphenyl) ethyl] -4-piperidyl group, 2- [3 -(2-Ethoxyphenyl) propyl] -3-piperidyl group, 3- [4- (3-ethoxyphenyl) butyl] -4-piperidyl group, 4- [5- (4-ethoxyphenyl) pentyl] -3- Piperidyl group, 3- [6- (4-n-propoxyphenyl) hexyl-2-piperidyl group, 2- (4-tert-butoxybenzyl) -1-piperidyl group, 1- (4-n-butoxybenzyl)- 2-piperidyl group, 2- (2-trifluoromethoxybenzyl) -3-piperidyl group, 3- (3-trifluoromethoxybenzyl) -4-piperidyl group, 4- (4-trifluoromethoxy) Ndyl) -1-piperidyl group, 3- (2-pentafluoroethoxybenzyl) -2-piperidyl group, 2- (4-pentafluoroethoxybenzyl) -1-piperidyl group, 1- (2,3-dimethoxybenzyl) -4-piperidyl group, 4- (3,4,5-trimethoxybenzyl) -1-piperidyl group, 4- (4-n-pentyloxybenzyl) -1-piperidyl group, 4- (4-n-hexyl) (Oxybenzyl) -1-piperidyl group, 4-benzyl-3-phenoxy-1-piperidyl group, 4-benzyloxymethyl-1-piperidyl group, 2,4-dibenzyloxymethyl-1-piperidyl group, 2,4 , 6-Tribenzyloxymethyl-1-piperidyl group, 2-[(2-fluorobenzyloxy) methyl] -1-piperidyl group, 3- {2- [2- (3 Fluorophenyl) ethoxy] ethyl} -2-piperidyl group, 4- {1- [1- (4-fluorophenyl) ethyl] ethoxy} -3-piperidyl group, 2- {3- [3- (2-chlorophenyl) Propoxy] propyl} -4-piperidyl group, 3- {4- [4- (3-chlorophenyl) butoxy] butyl} -5-piperidyl group, 4- {5- [5- (4-chlorophenyl) pentyloxy] pentyl } -2-piperidyl group, 5- {6- [6- (2-bromophenyl) hexyloxy] -2-piperidyl group, 6- (3-bromobenzyloxymethyl) -3-piperidyl group, 4- (4 -Bromobenzyloxymethyl) -1-piperidyl group, 3- (2,3-dichlorobenzyloxymethyl) -2-piperidyl group, 4- (3,4-dichlorobenzyloxyme) Til) -3-piperidyl group, 3- (2,4-dichlorobenzyloxymethyl) -4-piperidyl group, 2- (3,4,5-trichlorobenzyloxymethyl) -3-piperidyl group, 6- (2 , 4,6-Trichlorobenzyloxymethyl) -2-piperidyl group, 3- (2,3,4,5,6-pentafluorobenzyloxymethyl) -1-piperidyl group, 4- (2-methylbenzyloxymethyl) ) -1-piperidyl group, 5- {2- [2- (3-methylphenyl) ethoxy] ethyl} -2-piperidyl group, 6- {3- [3- (4-methylphenyl) propoxy] propyl}- 3-piperidyl group, 1- {4- [4- (2-ethylphenyl) butoxy] butyl} -4-piperidyl group, 2- {5- [5- (3-ethylphenyl) pentyloxy] pentyl} 1-piperidyl group, 3- {6- [6- (4-ethylphenyl) hexyloxy] hexyl} -2-piperidyl group, 4- (4-n-propylbenzyloxymethyl) -3-piperidyl group, 3- (4-tert-butylbenzyloxymethyl) -4-piperidyl group, 2- (4-n-butylbenzyloxymethyl) -3-piperidyl group, 1- (2-trifluoromethylbenzyloxymethyl) -2-piperidyl Group, 2- (3-trifluoromethylbenzyloxymethyl) -1-piperidyl group, 4- (4-trifluoromethylbenzyloxymethyl) -1-piperidyl group, 1- (2-pentafluoroethylbenzyloxymethyl) -4-piperidyl group, 1- (3-pentafluoroethylbenzyloxymethyl) -4-piperidyl group, 4- (2,3- Methylbenzyloxymethyl) -1-piperidyl group, 1- (3,4,5-trimethylbenzyloxymethyl) -4-piperidyl group, 1- (4-n-pentylbenzyloxymethyl) -4-piperidyl group, 4 -(4-n-hexylbenzyloxymethyl) -1-piperidyl group, 4- (2-methoxybenzyloxymethyl) -1-piperidyl group, 1- {2- [2- (3-methoxyphenyl) ethoxy] ethyl } -4-piperidyl group, 1- {1- [1- (4-methoxyphenyl) ethoxy] ethyl} -4-piperidyl group, 2- {3- [3- (2-ethoxyphenyl) propoxy] propyl}- 3-piperidyl group, 3- {4- [4- (3-ethoxyphenyl) butoxy] butyl-4-piperidyl group, 4- {5- [5- (4-ethoxyphenyl) penti Ruoxy] pentyl} -3-piperidyl group, 3- {6- [6- (4-n-propoxyphenyl) hexyloxy] hexyl} -2-piperidyl group, 2- (4-tert-butoxybenzyloxymethyl)- 1-piperidyl group, 1- (4-n-butoxybenzyloxime)



Til) -2-piperidyl group, 2- (2-trifluoromethoxybenzyloxymethyl) -3-piperidyl group, 3- (3-trifluoromethoxybenzyloxymethyl) -4-piperidyl group, 4- (4-tri Fluoromethoxybenzyloxymethyl) -1-piperidyl group, 3- (2-pentafluoroethoxybenzyloxymethyl) -2-piperidyl group, 2- (4-pentafluoroethoxybenzyloxymethyl) -1-piperidyl group, 1- (2,3-dimethoxybenzyloxymethyl) -4-piperidyl group, 4- (3,4,5-trimethoxybenzyloxymethyl) -1-piperidyl group, 4- (4-n-pentyloxybenzyloxymethyl) -1-piperidyl group, 4- (4-n-hexyloxybenzyloxymethyl) -1-piperidyl group 4-benzyloxymethyl-3-phenoxy-1-piperidyl group, 4-benzyl-3-phenoxy-1-piperidyl group, 4- (4-chlorophenoxymethyl)-(1-, 2- or 3-) piperidyl group A piperidyl group such as a phenoxy group on the piperidine ring (from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring. 1 to 5, preferably 1 to 3 groups selected, phenyl C1-6 alkoxy substituted C1-6 alkyl group (on the phenyl ring, halogen atom, halogen substituted or unsubstituted 1 to 5, preferably 1 to 3 groups selected from the group consisting of a C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. A phenoxy C1-6 alkyl group in which the alkyl portion is a linear or branched alkyl group having 1 to 6 carbon atoms (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1 1 to 5, preferably 1 to 3 groups selected from the group consisting of -6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups) and phenyl C1-6 alkyl groups (1-5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring, preferably 1 1 to 3 groups may be substituted, which may be substituted with 1 to 3 groups selected from the group consisting of optionally 3 substituents).

  A benzothienyl C1-6 alkyl group (on the benzothiophene ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; Examples of the optionally substituted group include [[2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] methyl group, 1-[(2-, 3- , 4-, 5-, 6- or 7-) benzothienyl] ethyl group, 2-[(2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] ethyl group, 3- [ (2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] propyl group, 2-[(2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] Propyl group, 4-[(2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] bu 5-[(2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] pentyl group, 4-[(2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] pentyl group, 6-[(2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] hexyl group, 2-methyl-3-[(2-, 3- , 4-, 5-, 6- or 7-) benzothienyl] propyl group, 1,1-dimethyl-2-[(2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] Ethyl group, 5-chloro- (2-, 3-, 4-, 6- or 7-) benzothienylmethyl group, 5-methyl- (2-, 3-, 4-, 6- or 7-) benzothienyl Methyl group, 5-methoxy- (2-, 3-, 4-, 6- or 7-) benzothienylmethyl group, 5-trifluoromethyl- (2-, 3-, 4-, 6- 7-) benzothienylmethyl group, 5-trifluoromethoxy- (2-, 3-, 4-, 6- or 7-) benzothienylmethyl group, 5,6-dichloro- (2-, 3-, 4 -Or 7-) benzothienylmethyl group, 4,5,6-trifluoro- (2-, 3-, or 7-) benzothienylmethyl group, 5-chloro-6-trifluoromethoxy- (2-, 3-, 4- or 7-) benzothienylmethyl group, 2,5-dimethyl- (3-, 4-, 6- or 7-) benzothienylmethyl group, 2,5,6-trimethyl- (3-, 4- or 7-) benzothienyl C1-6 alkyl group in which the alkyl moiety such as benzothienylmethyl group is a linear or branched alkyl group having 1 to 6 carbon atoms (on the benzothiophene ring, a halogen atom, Halogen-substituted or unsubstituted C1-6 alkyl And 1 to 3 groups selected from the group consisting of a halogen group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted.

  A thiazolyl C1-6 alkyl group [on the thiazole ring, at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 As the group [which may be substituted with at least one group selected from the group consisting of alkoxy groups] may be substituted, for example, [(2-, 4- or 5-) thiazolyl] methyl group , 1-[(2-, 4- or 5-) thiazolyl] ethyl group, 2-[(2-, 4- or 5-) thiazolyl] ethyl group, 3-[(2-, 4- or 5-) Thiazolyl] propyl group, 2-[(2-, 4- or 5-) thiazolyl] propyl group, 4-[(2-, 4- or 5-) thiazolyl] butyl group, 5-[(2-, 4- Or 5-) thiazolyl] pentyl group, 4-[(2- 4- or 5-) thiazolyl] pentyl group, 6-[(2-, 4- or 5-) thiazolyl] hexyl group, 2-methyl-3-[(2-, 4- or 5-) thiazolyl] propyl group 1,1-dimethyl-2-[(2-, 4- or 5-) thiazolyl] ethyl group, 2- (4-trifluoromethylphenyl)-(4- or 5-) thiazolylmethyl group, 2- (4 -Trifluoromethylphenyl)-(4- or 5-) thiazolylmethyl group, 2- (4-trifluoromethoxyphenyl)-(4- or 5-) thiazolylmethyl group, 4- (3-methylphenyl)-(2- Or 5-) thiazolylmethyl group, 5- (2-methoxyphenyl)-(2- or 5-) thiazolylmethyl group, 4- (4-chlorophenyl)-(2- or 5-) thiazolylmethyl group, 2- (2,4 -Jimee Ruphenyl)-(4- or 5-) thiazolylmethyl group, 2- (2,4,6-trimethylphenyl)-(4- or 5-) thiazolylmethyl group, 2- (3,4-dimethoxyphenyl)-(4- Or 5-) thiazolylmethyl group, 2- (3,4,5-trimethoxyphenyl)-(4- or 5-) thiazolylmethyl group, 2- (3-chloro-4-trifluoromethylphenyl)-(4- or 5-) thiazolylmethyl group, 4- (3,4-dichlorophenyl)-(2- or 5-) thiazolylmethyl group, 2- (3,4,6-trifluorophenyl)-(4- or 5-) thiazolylmethyl group, Thiazolyl C1-6 alkyl group wherein the alkyl moiety such as 2,4-diphenyl- (4- or 5-) thiazolylmethyl group is a linear or branched alkyl group having 1 to 6 carbon atoms [thiazo 1 to 2 phenyl groups (on the phenyl ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring. 1 to 5 groups, more preferably 1 to 3 groups, which may be substituted) may be substituted.

  An indolyl C1-6 alkyl group (on the indole ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) As the species may be substituted, for example, [(1-, 2-, 3-, 4-, 5-, 6- or 7-) indolyl] methyl group, 1-[(1-, 2) -, 3-, 4-, 5-, 6- or 7-) indolyl] ethyl group, 2-[(1-, 2-, 3-, 4-, 5-, 6- or 7-) indolyl] ethyl Group, 3-[(1-, 2-, 3-, 4-, 5-, 6- or 7-) indolyl] propyl group, 2-[(1-, 2-, 3-, 4-, 5- , 6- or 7-) indolyl] propyl group, 4-[(1-, 2-, 3-, 4-, 5-, 6- or 7-) indolyl Butyl group, 5-[(1-, 2-, 3-, 4-, 5-, 6- or 7-) indolyl] pentyl group, 4-[(1-, 2-, 3-, 4-, 5 -, 6- or 7-) indolyl] pentyl group, 6-[(1-, 2-, 3-, 4-, 5-, 6- or 7-) indolyl] hexyl group, 2-methyl-3- [ (1-, 2-, 3-, 4-, 5-, 6- or 7-) indolyl] propyl group, 1,1-dimethyl-2-[(1-, 2-, 3-, 4-, 5 -, 6- or 7-) indolyl] ethyl group, 2-trifluoromethyl- (1-, 3-, 4-, 5-, 6- or 7-) indolylmethyl group, 5-trifluoromethyl- ( 1-, 2-, 3-, 4-, 6- or 7-) indolylmethyl group, 2-trifluoromethoxy- (1-, 3-, 4-, 5-, 6- or 7-) indolyl 4-methyl- (1-, 2-, 3-, 5-, 6- or 7-) indolylmethyl group, 5-methoxy- (1-, 2-, 3-, 4-, 6- Or 7-) indolylmethyl group, 4-chloro- (1-, 2-, 3-, 5-, 6- or 7-) indolylmethyl group, 2,4-dimethyl- (1-, 3-, 5-, 6- or 7-) indolylmethyl group, 2,4,6-trimethyl- (1-, 3-, 5- or 7-) indolylmethyl group, 3,4-dimethoxy- (1-, 2-, 5-, 6- or 7-) indolylmethyl group, 3,4,5-trimethoxy- (1-, 2-, 6- or 7-) indolylmethyl group, 3-chloro-4-tri Fluoromethyl- (1-, 2-, 5-, 6- or 7-) indolylmethyl group, 3,4-dichloro- (1-, 2-, 5-, 6- or 7-) indole Rumethyl group, 3,4,6-trifluoro- (1-, 2-, 5- or 7-) indolylmethyl group, 5-trifluoromethoxy- (1-, 2-, 3-, 4-, 6 -Or 7-) indolylmethyl group, 5-trifluoromethoxy-6-chloro- (1-, 2-, 3-, 4- or 7-) indolylmethyl group, 1,3-dimethyl-5-fluoro -(2-, 4-, 6- or 7-) indolyl C1-6 alkyl group wherein the alkyl moiety such as indolylmethyl group is a linear or branched alkyl group having 1 to 6 carbon atoms (on the indole ring) 1 to 3 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) Can be mentioned.

  A phenyl C1-6 alkyl group (on the phenyl ring, a group selected from the group consisting of a benzofuryl group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; As the above-mentioned phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group). In addition to 4-((2-, 3-, 4-, 5-, 6- or 7-), at least one group selected from the group consisting of C1-6 alkoxy groups may be substituted. ) Benzofuryl] benzyl group, 2-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] benzyl group, 3-[(2-, 3-, 4-, 5-, 6) -Or 7-) benzofuryl Benzyl group, 3,4-di [(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] benzyl group, 2,4,6-tri [(2-, 3-, 4- , 5-, 6- or 7-) benzofuryl] benzyl group, 3-chloro-4-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] benzyl group and the like. A phenyl C1-6 alkyl group which is a linear or branched alkyl group having 1 to 6 carbon atoms (on the phenyl ring, a benzofuryl group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted group) Or 1 to 5, preferably 1 to 3 groups selected from the group consisting of unsubstituted C1-6 alkoxy groups.

Pyridyloxy group ((d-1) piperidyl group on pyridine ring [phenoxy group on piperidine ring (halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted on phenyl ring) Or at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted), a phenyl C1-6 alkoxy-substituted C1-6 alkyl group (on the phenyl ring, a halogen atom) , At least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted), phenoxy C1-6 alkyl A group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 And at least one group selected from the group consisting of a alkoxy group may be substituted) and a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group) And at least one group selected from the group consisting of a group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted) Good] and (d-2) piperazinyl group [on the piperazine ring a C1-6 alkoxycarbonyl group, a furyl C1-6 alkyl group [on the furan ring, at least one phenyl group (on the phenyl ring, At least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group May be substituted)], pyridyl C1-6 alkyl group [furyl group and phenyl group on the pyridine ring (halogen atom, halogen-substituted or unsubstituted on phenyl ring) At least one group selected from the group consisting of a C1-6 alkyl group and a group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted). Optionally substituted], a benzothienyl C1-6 alkyl group (on the benzothiophene ring, from a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one group selected from the group consisting of: a phenyl C2-6 alkenyl group (on the phenyl ring, a halogen atom, a halogen substitution) May be substituted with at least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group), a benzofuryl C1-6 alkyl group [benzofuran On the ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. A benzofuryl C2-6 alkenyl group [on the benzofuran ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] At least one may be substituted], a thiazolyl C1-6 alkyl group [on the thiazole ring, at least one phenyl group (a On the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. May be substituted)], a phenoxy C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one group selected from the group consisting of: an indolyl C1-6 alkyl group (on the indole ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen) At least one group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted) and phenyl C1-6 alkyl (On the phenyl ring, at least one group selected from the group consisting of a benzofuryl group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. At least one group selected from the group consisting of a group selected from the group consisting of: 2-pyridyloxy group, 3-pyridyloxy group, 4-pyridyloxy group, 3- (1-piperidyl) -2-pyridyloxy group, 2- (4-piperidyl) -3-pyridyloxy group, 4- ( 2-piperidyl) -3-pyridyloxy group, 5- (3-piperidyl) -2-pyridyloxy group, 2,4-di (1-piperidyl) -3-pyridyloxy group, 2- (1-piperidyl group) ) -4- [2- (2-Fluorophenoxy) -1-piperidyl] -3-pyridyloxy group, 2,4,6-tri (1-piperidyl) -3-pyridyloxy group, 2- (4-phenoxy) -1-piperidyl) -3-pyridyloxy group, 2- (2,4-diphenoxy-1-piperidyl) -3-pyridyloxy group, 3- (2,4,6-triphenoxy-1-piperidyl) -4 -Pyridyloxy group, 4- [2- (2-fluorophenoxy) -1-piperidyl] -2-pyridyloxy group, 5- [3- (3-fluorophenoxy) -2-piperidyl] -3-pyridyloxy group , 6- [4- (4-Fluorophenoxy) -3-piperidyl] -4-pyridyloxy group, 2- [2- (2-chlorophenoxy) -4-piperidyl] -3-pyridyloxy group, 3- [ 3- ( 3-chlorophenoxy) -5-piperidyl] -4-pyridyloxy group, 4- [4- (4-chlorophenoxy) -2-piperidyl] -2-pyridyloxy group, 5- [5- (2-bromophenoxy) ) -2-Piperidyl] -3-pyridyloxy group, 2- [6- (3-bromophenoxy) -3-piperidyl] -4-pyridyloxy group, 2- [4- (4-bromophenoxy) -1- Piperidyl] -2-pyridyloxy group, 3- [3- (2,3-dichlorophenoxy) -2-piperidyl] -4-pyridyloxy group, 3- [4- (3,4-dichlorophenoxy) -3- Piperidyl] -4-pyridyloxy group, 4- [3- (2,4-dichlorophenoxy) -4-piperidyl] -2-pyridyloxy group, 5- [2- (3,4,5-trichlorophenoxy)- 3- Peridyl] -2-pyridyloxy group, 6- [6- (2,4,6-trichlorophenoxy) -2-piperidyl] -3-pyridyloxy group, 2- [3- (2,3,4,5, 6-pentafluorophenoxy) -1-piperidyl] -3-pyridyloxy group, 4- [4- (2-methylphenoxy) -1-piperidyl] -2-pyridyloxy group, 3- [5- (3-methyl Phenoxy) -2-piperidyl] -2-pyridyloxy group, 5- [6- (4-methylphenoxy) -3-piperidyl] -3-pyridyloxy group, 2- [1- (2-ethylphenoxy) -4 -Piperidyl] -4-pyridyloxy group, 2- [2- (3-ethylphenoxy) -1-piperidyl] -3-pyridyloxy group, 3- [3- (4-ethylphenoxy) -2-piperidyl]- 4-pyri Ruoxy group, 4- [4- (4-n-propylphenoxy) -3-piperidyl] -2-pyridyloxy group, 5- [5- (4-tert-butylphenoxy) -4-piperidyl] -3-pyridyl Oxy group, 6- [2- (4-n-butylphenoxy) -3-piperidyl] -2-pyridyloxy group, 2- [1- (2-trifluoromethylphenoxy) -2-piperidyl] -4-pyridyl Oxy group, 3- [2- (3-trifluoromethylphenoxy) -1-piperidyl] -4-pyridyloxy group, 4- [3- (4-trifluoromethylphenoxy) -1-piperidyl] -2-pyridyl Oxy group, 5- [1- (2-pentafluoroethylphenoxy) -4-piperidyl] -3-pyridyloxy group, 6- [1- (3-pentafluoroethylphenoxy) -4 -Piperidyl] -2-pyridyloxy group, 2- [4- (2,3-dimethylphenoxy) -1-piperidyl] -3-pyridyloxy group, 3- [1- (3,4,5-trimethylphenoxy) -4-piperidyl] -2-pyridyloxy group, 4- [1- (4-n-pentylphenoxy) -4-piperidyl] -3-pyridyloxy group, 5- [4- (4-n-hexylphenoxy) -1-piperidyl] -2-pyridyloxy group, 6- [4- (2-methoxyphenoxy) -1-piperidyl] -2-pyridyloxy group, 2- [1- (3-methoxyphenoxy) -4-piperidyl ] -4-pyridyloxy group, 3- [1- (4-methoxyphenoxy) -4-piperidyl] -2-pyridyloxy group, 4- [2- (2-ethoxyphenoxy) -3-piperidyl] -2- Lysyloxy group, 5- [3- (3-ethoxyphenoxy) -4-piperidyl] -3-pyridyloxy group, 2- [4- (4-ethoxyphenoxy) -5-piperidyl] -4-pyridyloxy group, 2 -[3- (4-n-propoxyphenoxy) -2-piperidyl] -4-pyridyloxy group, 3- [2- (4-tert-butoxyphenoxy) -1-piperidyl] -4-pyridyloxy group, 4 -[1- (4-n-butoxyphenoxy) -2-piperidyl] -2-pyridyloxy group, 5- [2- (2-trifluoromethoxyphenoxy) -3-piperidyl] -2-pyridyloxy group, 6 -[3- (3-trifluoromethoxyphenoxy) -4-piperidyl] -2-pyridyloxy group, 6- [4- (4-trifluoromethoxyphenoxy) -3-pipe Dil] -2-pyridyloxy group, 2- [3- (2-pentafluoroethoxyphenoxy) -2-piperidyl] -3-pyridyloxy group, 3- [4- (4-pentafluoroethoxyphenoxy) -1- Piperidyl] -2-pyridyloxy group, 4- [1- (2,3-dimethoxyphenoxy) -4-piperidyl] -2-pyridyloxy group, 5- [4- (3,4,5-trimethoxyphenoxy) -1-piperidyl] -3-pyridyloxy group, 6- [4- (4-n-pentyloxyphenoxy) -1-piperidyl] -3-pyridyloxy group, 5- [4- (4-n-hexyloxy) Phenoxy) -1-piperidyl] -3-pyridyloxy group, 2- [4- (4-trifluoromethylbenzyloxymethyl) -1-piperidyl] -5-pyridyloxy group, 2- (4-trifluoromethoxybenzyl-1-piperidyl) -5-pyridyloxy group, 2- [4- (4-chlorobenzyl) -1-piperazinyl] -5-pyridyloxy group, 2- [4- (4- Trifluoromethylbenzyl) -1-piperazinyl] -5-pyridyloxy group, 2- [4- (4-chlorobenzyloxymethyl) -1-piperidyl] -5-pyridyloxy group, 4- (4-fluorobenzyl- 1-piperazinyl) -6-pyridyloxy group, 4-phenoxy-3- [4- (4-trifluoromethoxybenzyloxymethyl) -1-piperidyl] -2-pyridyloxy group, 2- [4-tert-butoxy Carbonyl- (1-, 2- or 3-) piperazinyl]-(3-, 4-, 5- or 6-) pyridyloxy group, 2- [4- {4-[(2-, 3- 4-, 5-, 6- or 7-) benzofuryl] benzyl}-(1-, 2- or 3-) piperazinyl]-(3-, 4-, 5- or 6-) pyridyloxy group, 2- [ 4- {3-[(2- or 3-) furyl] pyridylmethyl}-(1-, 2- or 3-) piperazinyl]-(3-, 4-, 5- or 6-) pyridyloxy group, 2 -{4- [2- (4-trifluoromethoxyphenyl) pyridylmethyl]-(1-, 2- or 3-) piperazinyl}-(3-, 4-, 5- or 6-) pyridyloxy group, 2 -{4- [2- (3-chloro-4-fluorophenyl) pyridylmethyl]-(1-, 2- or 3-) piperazinyl}-(3-, 4-, 5- or 6-) pyridyloxy group , 2- {4- [5-trifluoromethyl- (2-, 3-, 4-, 6- or 7-) benzo Rylmethyl]-(1-, 2- or 3-) piperazinyl}-(3-, 4-, 5- or 6-) pyridyloxy group, 2- {4- [6-trifluoromethyl- (2-, 3 -, 4-, 5- or 7-) benzofurylmethyl]-(1-, 2- or 3-) piperazinyl}-(3-,



4-, 5- or 6-) pyridyloxy group, 2- {4- [5-chloro- (2-, 3-, 4-, 6- or 7-) benzothienylmethyl]-(1-, 2- Or 3-) piperazinyl}-(3-, 4-, 5- or 6-) pyridyloxy group, 2- {4- [6-chloro- (2-, 3-, 4-, 5- or 7-) Benzofurylmethyl]-(1-, 2- or 3-) piperazinyl}-(3-, 4-, 5- or 6-) pyridyloxy group, 2- {4- [5-trifluoromethoxy- (2- , 3-, 4-, 6- or 7-) benzofurylmethyl]-(1-, 2- or 3-) piperazinyl}-(3-, 4-, 5- or 6-) pyridyloxy group, 2- {4- [3- (4-trifluoromethylphenyl) -2-propenyl]-(1-, 2- or 3-) piperazinyl} pyridyloxy 2- {4- [3- (3,4-dichlorophenyl) -2-propenyl]-(1-, 2- or 3-) piperazinyl} pyridyloxy group, 2- {4- [3- (4-chlorophenyl) ) -2-propenyl]-(1-, 2- or 3-) piperazinyl} pyridyloxy group, 2- [4- {3- [6-trifluoromethyl- (2-, 3-, 4-, 5- Or 7-) benzofuryl] -2-propenyl}-(1-, 2- or 3-) piperazinyl] pyridyloxy group, 2- [4- {3- [5-chloro- (2-, 3-, 4- , 5- or 7-) benzofuryl] -2-propenyl}-(1-, 2- or 3-) piperazinyl] pyridyloxy group, 2- {4- [5-chloro- (2-, 3-, 4- , 6- or 7-) benzofurylmethyl]-(1-, 2- or 3-) piperazinyl} (3-, 4-, 5- or 6-) pyridyloxy group, 2- {4- [2- (4-trifluoromethylphenyl)-(4- or 5-) thiazolylmethyl]-(1-, 2- Or 3-) piperazinyl} pyridyloxy group, 2- {4- [2- (4-trifluoromethoxyphenoxy) ethyl]-(1-, 2- or 3-) piperazinyl} pyridyloxy group, 2- {4- [3- (4-Trifluoromethoxyphenyl) -2-propenyl]-(1-, 2- or 3-) piperazinyl} pyridyloxy group, 2- {4- [5-trifluoromethoxy- (1-2) -, 3-, 4-, 6- or 7-) indolylmethyl]-(1-, 2- or 3-) piperazinyl} pyridyloxy group, 2- [4- (4-chlorophenoxymethyl)-(1 -, 2- or 3-) piperidyl]-(3 -, 4-, 5- or 6-) pyridyloxy group, 2- {4- [2- (4-chlorophenyl)-(3-, 4- or 5-) furylmethyl]-(1-, 2- or 3-) Piperazinyl} pyridyloxy group, 2- {4- [2- (2-chloro-5-trifluoromethylphenyl)-(3-, 4- or 5-) furylmethyl]-(1-, 2- Or 3-) a pyridyloxy group such as a piperazinyl} pyridyloxy group (on the pyridine ring, a piperidyl group [on the piperidine ring, a phenoxy group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1 1 to 5, preferably 1 to 3 groups selected from the group consisting of 6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups), phenyl C1-6 alkoxy-substituted C1 ~ 6 alkyl groups 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group on the nyl ring, preferably 1 to 3 may be substituted), a phenoxy C1-6 alkyl group in which the alkyl portion is a linear or branched alkyl group having 1 to 6 carbon atoms (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted 1 to 5, preferably 1 to 3 groups selected from the group consisting of substituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups) and phenyl C1 6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) 1 to 5, preferably 1 to 3 groups selected from the group consisting of at least one group selected from the group may be substituted] and a piperazinyl group [piperazine On the ring, a C1-6 alkoxycarbonyl group, a furyl C1-6 alkyl group in which the alkyl portion is a linear or branched alkyl group having 1 to 6 carbon atoms [on the furan ring, 1 to 3 Phenyl group (on the phenyl ring, 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group, preferably May be substituted by 1 to 3)], a pyridyl C1-6 alkyl group in which the alkyl portion is a linear or branched alkyl group having 1 to 6 carbon atoms [pyridine ring Above, furyl and phen Nyl group (on the phenyl ring, preferably 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group, May be substituted with 1 to 3 groups selected from the group consisting of 1 to 3), and the alkyl moiety is a straight or branched alkyl having 1 to 6 carbon atoms Benzothienyl C1-6 alkyl group which is a group (on the benzothiophene ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group are selected. A linear or branched alkenyl group having 2 to 6 carbon atoms in the alkenyl moiety and 1 to 3 double bonds, Enclose both cis bodies A phenyl C2-6 alkenyl group (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group). 1 to 5, preferably 1 to 3), a benzofuryl C1-6 alkyl group in which the alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms [on the benzofuran ring May be substituted with 1 to 3 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group], A benzofuryl C2-6a which is a linear or branched alkenyl group having 2 to 6 carbon atoms and having 1 to 3 double bonds, including both trans and cis isomers Kenyl group [On the benzofuran ring, 1 to 3 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group are substituted. A thiazolyl C1-6 alkyl group in which the alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms [on the thiazole ring, 1 to 2 phenyl groups (on the phenyl ring)]. Is substituted with 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups A phenoxy C1-6 alkyl group in which the alkyl portion is a linear or branched alkyl group having 1 to 6 carbon atoms (on the phenyl ring, a halogen atom) , 1 to 5 groups, preferably 1 to 3 groups selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted) , An indolyl C1-6 alkyl group in which the alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms (on the indole ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen atom) 1 to 3 groups selected from the group consisting of a substituted or unsubstituted C1-6 alkoxy group may be substituted, and a phenyl C1-6 alkyl group (on the phenyl ring, a benzofuryl group, a halogen atom, 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group are substituted. And selected from the group consisting of may also be) group can be exemplified groups may be 1-3 substituents selected from the group) consisting of may be in 1-3 substituents.

  1,2,3,4-tetrahydroquinolyloxy group (oxo group, phenyl group on 1,2,3,4-tetrahydroquinoline ring [halogen atom, halogen-substituted or unsubstituted on phenyl ring At least one group selected from the group consisting of a C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] and a phenyl C1-6 alkyl group [on the phenyl ring , At least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] Examples of the group selected from at least one selected from the above groups include 1,2,3,4-tetrahydro- (1-, 2-, 3-, 4-, 5-). -, 6-, 7- or 8-) quinolyloxy group, 1- (4-trifluoromethylbenzyl) -2-oxo-1,2,3,4-tetrahydro-6-quinolyloxy group, 1- (4-tri Fluoromethoxybenzyl) -2-oxo-1,2,3,4-tetrahydro-6-quinolyloxy group, 1- (4-chlorobenzyl) -2-oxo-1,2,3,4-tetrahydro-6-quinolyloxy group Group, 1- (4-trifluoromethylbenzyl) -1,2,3,4-tetrahydro-6-quinolyloxy group, 1- (4-trifluoromethoxybenzyl) -1,2,3,4-tetrahydro-6 -Quinolyloxy group, 1- (4-chlorobenzyl) -1,2,3,4-tetrahydro-6-quinolyloxy group, 1- (4-chlorophenyl) -1,2,3,4-tetrahydro 6-quinolyloxy group, 1- (4-trifluoromethoxyphenyl) -1,2,3,4-tetrahydro-6-quinolyloxy group, 1- (4-trifluoromethylphenyl) -1,2,3,4- Tetrahydro-6-quinolyloxy group, 1- (3,4-dichlorobenzyl) -1,2,3,4-tetrahydro-6-quinolyloxy group, 1- [3,4-di (trifluoromethoxy) benzyl] -1 , 2,3,4-tetrahydro-6-quinolyloxy group, 1- (4-chlorophenyl) -1,2,3,4-tetrahydro-5-quinolyloxy group, 1- (4-trifluoromethoxyphenyl) -1, 2,3,4-tetrahydro-5-quinolyloxy group, 1- (4-trifluoromethylphenyl) -1,2,3,4-tetrahydro-5-quinolyloxy group, -(4-chlorobenzyl) -1,2,3,4-tetrahydro-5-quinolyloxy group, 1- (4-trifluoromethoxybenzyl) -1,2,3,4-tetrahydro-5-quinolyloxy group, 1 -(4-trifluoromethylbenzyl) -1,2,3,4-tetrahydro-5-quinolyloxy group, 1- [3,4,5-tri (trifluoromethyl) benzyl] -1,2,3,4 -Tetrahydro-6-quinolyloxy group, 1-benzyl-4-phenyl-1,2,3,4-tetrahydro-6-quinolyloxy group, 1-phenyl-4,6-dibenzyl-1,2,3,4-tetrahydro 1,2,3,4-tetrahydroquinolyloxy group such as -5-quinolyloxy group, 4-phenyl-2-oxo-1,2,3,4-tetrahydro-1-quinolyloxy group [1 , 2,3,4-tetrahydroquinoline ring, oxo group, phenyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 1 to 5, preferably 1 to 3 groups selected from the group consisting of alkoxy groups and phenyl C1-6 alkyl groups (on the phenyl ring, halogen atoms, halogen-substituted or unsubstituted) 1 to 5, preferably 1 to 3 groups selected from the group consisting of substituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups) 1 to 3 selected groups may be substituted].

  As a 1,2,3,4-tetrahydronaphthyloxy group (at least one oxo group may be substituted on the 1,2,3,4-tetrahydronaphthalene ring), for example, (1- 2-, 5- or 6-) 1,2,3,4-tetrahydronaphthyloxy group, 4-oxo-7-1,2,3,4-tetrahydronaphthyloxy group, 1,4-dioxo-6- 1,2,3,4-tetrahydronaphthyloxy group such as 1,2,3,4-tetrahydronaphthyloxy group, 1,2,4-trioxo-5-1,2,3,4-tetrahydronaphthyloxy group ( 1 to 3 oxo groups may be substituted on the 1,2,3,4-tetrahydronaphthalene ring).

  Examples of the 2H-chromenioxyl group (at least one oxo group may be substituted on the 2H-chromene ring) include, for example, 2H-chromenioxyl such as 2H-chromenioxyl group and 2-oxo-2H-chromenioxyl group. And a group (at least one oxo group may be substituted on the 2H-chromene ring).

  Naphtyloxy group (at least one piperidyl group on the naphthalene ring [at least one phenoxy group on the piperidine ring (halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group on the phenyl ring) And at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups, which may be substituted) may be substituted] For example, (1- or 2-) naphthyloxy group, 6- [4- (4-trifluoromethoxyphenoxy) -1-piperidyl] -2-naphthyloxy group, 5- (1-piperidyl) -2-naphthyl Oxy group, 2- (4-piperidyl) -3-naphthyloxy group, 4- (2-piperidyl) -1-naphthyloxy group, 5- (3-piperidyl) -2-naphthyloxy A group, 5,6-di (1-piperidyl) -1-naphthyloxy group, 7- (1-piperidyl) -6- [2- (2-fluorophenoxy) -1-piperidyl] -1-naphthyloxy group, 5,6,7-tri (1-piperidyl) -2-naphthyloxy group, 6- (4-phenoxy-1-piperidyl) -3-naphthyloxy group, 2- (2,4-diphenoxy-1-piperidyl) -4-naphthyloxy group, 3- (2,4,6-triphenoxy-1-piperidyl) -5-naphthyloxy group, 4- [2- (2-fluorophenoxy) -1-piperidyl] -6-naphthyl Oxy group, 4- [3- (3-fluorophenoxy) -2-piperidyl] -2-naphthyloxy group, 3- [4- (4-fluorophenoxy) -3-piperidyl] -1-naphthyloxy group, 5 − [2- 2-chlorophenoxy) -4-piperidyl] -2-naphthyloxy group, 6- [3- (3-chlorophenoxy) -5-piperidyl] -1-naphthyloxy group, 4- [4- (4-chlorophenoxy) ) -2-Piperidyl] -2-naphthyloxy group, 5- [5- (2-bromophenoxy) -2-piperidyl] -3-naphthyloxy group, 6- [6- (3-bromophenoxy) -3- Piperidyl] -4-naphthyloxy group, 6- [4- (4-bromophenoxy) -1-piperidyl] -2-naphthyloxy group, 3- [3- (2,3-dichlorophenoxy) -2-piperidyl] -4-naphthyloxy group, 6- [4- (3,4-dichlorophenoxy) -3-piperidyl] -1-naphthyloxy group, 4- [3- (2,4-dichlorophenoxy) -4-piperidyl] 2-naphthyloxy group, 5- [2- (3,4,5-trichlorophenoxy) -3-piperidyl] -2-naphthyloxy group, 6- [6- (2,4,6-trichlorophenoxy)- 2-piperidyl] -3-naphthyloxy group, 2- [3- (2,3,4,5,6-pentafluorophenoxy) -1-piperidyl] -3-naphthyloxy group, 4- [4- (2 -Methylphenoxy) -1-piperidyl] -2-naphthyloxy group, 3- [5- (3-methylphenoxy) -2-piperidyl] -2-naphthyloxy group, 5- [6- (4-methylphenoxy) -3-piperidyl] -3-naphthyloxy group, 6- [1- (2-ethylphenoxy) -4-piperidyl] -4-naphthyloxy group, 2- [2- (3-ethylciphenoxy) -1- Piperidyl] -3-na Tiloxy group, 3- [3- (4-ethylphenoxy) -2-piperidyl] -4-naphthyloxy group, 4- [4- (4-n-propylphenoxy) -3-piperidyl] -2-naphthyloxy group , 5- [5- (4-tert-butylphenoxy) -4-piperidyl] -1-naphthyloxy group, 6- [2- (4-n-butylphenoxy) -3-piperidyl] -2-naphthyloxy group 2- [1- (2-trifluoromethylphenoxy) -2-piperidyl] -4-naphthyloxy group, 3- [2- (3-trifluoromethylphenoxy) -1-piperidyl] -4-naphthyloxy group 4- [3- (4-trifluoromethylphenoxy) -1-piperidyl] -2-naphthyloxy group, 5- [1- (2-pentafluoroethylphenoxy) -4-piperidi ] -3-Naphtyloxy group, 6- [1- (3-pentafluoroethylphenoxy) -4-piperidyl] -2-naphthyloxy group, 2- [4- (2,3-dimethylphenoxy) -1-piperidyl ] -1-naphthyloxy group, 3- [1- (3,4,5-trimethylphenoxy) -4-piperidyl] -2-naphthyloxy group, 4- [1- (4-n-pentylphenoxy) -4 -Piperidyl] -1-naphthyloxy group, 5- [4- (4-n-hexylphenoxy) -1-piperidyl] -2-naphthyloxy group, 6- [4- (2-methoxyphenoxy) -1-piperidyl ] -2-naphthyloxy group, 2- [1- (3-methoxyphenoxy) -4-piperidyl] -4-naphthyloxy group, 3- [1- (4-methoxyphenoxy) -4-piperidyl] -2- Naphthyloxy group, 4- [2- (2-ethoxyphenoxy) -3-piperidyl] -2-naphthyloxy group, 5- [3- (3-ethoxyphenoxy) -4-piperidyl] -1-naphthyloxy group, 6- [4- (4-ethoxyphenoxy) -5-piperidyl] -4-naphthyloxy group, 2- [3- (4-n-propoxyphenoxy) -2-piperidyl] -4-naphthyloxy group, 3- [2- (4-tert-butoxyphenoxy) -1-piperidyl] -4-naphthyloxy group, 4- [1- (4-n-butoxyphenoxy) -2-piperidyl] -2-naphthyloxy group, 5- [2- (2-trifluoromethoxyphenoxy) -3-piperidyl] -2-naphthyloxy group, 6- [3- (3-trifluoromethoxyphenoxy) -4-piperidyl] -2 Naphthyloxy group, 6- [4- (4-trifluoromethoxyphenoxy) -3-piperidyl] -2-naphthyloxy group, 2- [3- (2-pentafluoroethoxyphenoxy) -2-piperidyl] -3- Naphtyloxy group, 3- [4- (4-pentafluoroethoxyphenoxy) -1-piperidyl] -2-naphthyloxy group, 4- [1- (2,3-dimethoxyphenoxy) -4-piperidyl] -2- Naphthyloxy group, 5- [4- (3,4,5-trimethoxyphenoxy) -1-piperidyl] -1-naphthyloxy group, 6- [4- (4-n-pentyloxyphenoxy) -1-piperidyl ] -3-naphthyloxy group, 5- [4- (4-n-hexyloxyphenoxy) -1-piperidyl] -1-naphthyloxy group and the like 1 to 3 piperidyl groups [on the piperidine ring 1 to 3 phenoxy groups (on the phenyl ring, halogen atoms, halogen-substituted or unsubstituted C 1-6 alkyl groups and halogen 1 to 5, preferably 1 to 3 groups selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted] is substituted. May be included).

  1,2,3,4-tetrahydroisoquinolyloxy group (on a 1,2,3,4-tetrahydroisoquinoline ring, a C1-6 alkoxycarbonyl group, a phenyl C1-6 alkyl group [on the phenyl ring, A group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups). And at least one selected group may be substituted] and a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of alkoxy groups may be substituted], and at least one group selected from the group consisting of May be, for example, 1,2,3,4-tetrahydroisoquinolyl (1-, 2-, 3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy group 2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-6-isoquinolyloxy group, 2- (4-chlorobenzyl) -1,2,3,4-tetrahydro-6-isoquinolyl Oxy group, 2- (4-trifluoromethoxybenzyl) -1,2,3,4-tetrahydro-6-isoquinolyloxy group, 2- (4-trifluoromethylbenzyl) -1,2,3,4 -Tetrahydro-6-isoquinolyloxy group, 2-ethoxycarbonyl-4-benzyl-1,2,3,4-tetrahydro-7-isoquinolyloxy group, 1,4,6-tribenzyl-1,2, 3,4-tetrahydro-8 Isoquinolyloxy group, 1- [3,4-di (trifluoromethoxy) benzyl] -1,2,3,4-tetrahydro-6-isoquinolyloxy group, 1- [3,4,5-tri (Trifluoromethyl) benzyl] -1,2,3,4-tetrahydro-6-isoquinolyloxy group, 2- (4-trifluoromethoxyphenyl)-(1-, 3-, 4-, 5-, 1,2,3,4-tetrahydroisoquinolyloxy groups such as 6-, 7- or 8-) isoquinolyloxy groups (on the 1,2,3,4-tetrahydroisoquinoline ring, C1-6 alkoxy Carbonyl group, phenyl C1-6 alkyl group (on the phenyl ring, selected from the group consisting of halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups 1 to 5, preferably 1 to 3 groups) and the phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group. 1 to 5, preferably 1 to 3 groups selected from the group consisting of substituted C1-6 alkoxy groups] may be substituted with 1 to 3 groups selected from the group consisting of May be included).

  Phenyl group [on the phenyl ring at least one piperidyl group (on the piperidine ring at least one phenoxy group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and It is assumed that at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted] may be substituted. ], For example, 4- (1-piperidyl) phenyl group, 3- (2-piperidyl) phenyl group, 4- [4- (4-trifluoromethoxyphenoxy) -1-piperidyl] phenyl group, 4- [ 4- (4-trifluoromethylphenoxy) -1-piperidyl] phenyl group, 4- [4- (4-chlorophenoxy) -1-piperidyl] phenyl group, 4- {4- [3,4-di (tri Fluoromethoxy) phenoxy-1-piperidyl]} phenyl group, 4- {4- (3,4,5-tri (trifluoromethyl) phenoxy-1-piperidyl)} phenyl group, 4- [4- (2,4 -Dichlorophenoxy) -1-piperidyl] phenyl group, 4- [4- (2,4,6-trifluorophenoxy) -1-piperidyl] phenyl group, 2- (2,4,5-triphenoxy) 1-piperidyl) phenyl group, 3- (1,2-diphenoxy-4-piperidyl) phenyl group, 2,4-di (4-piperidyl) phenyl group, 2,4,6-tri (3-piperidyl) phenyl group A phenyl group such as 1 to 3 piperidyl groups on the phenyl ring (1 to 3 phenoxy groups on the piperidine ring [halogen atom, halogen-substituted or unsubstituted C1 1 to 5, preferably 1 to 3 groups selected from the group consisting of 6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted) Is replaced. ] Can be mentioned.

Phenyl C1-6 alkyl group [on the phenyl ring, at least one piperidyl group (on the piperidine ring, phenoxy group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and And at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted] and a group —NR ²⁴ R ²⁵ (R ²⁴ Represents a hydrogen atom or a C1-6 alkyl group, R ²⁵ represents a phenyl C2-6 alkenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted group. And at least one group selected from the group consisting of C1-6 alkoxy groups may be substituted].) At least one group selected from the group consisting of Examples of the group include 4- (1-piperidyl) benzyl group, 2,4-di (4-piperidyl) benzyl group, 2,4,6-tri (2-piperidyl) benzyl group, 4 -[4- (4-trifluoromethoxyphenoxy) -1-piperidyl] benzyl group, 4- [N-methyl-N- (4-trifluoromethoxycinnamyl) amino] benzyl group, 4- [N- (4 -Trifluoromethoxycinnamyl) amino] benzyl group, 4- [4- (4-trifluoromethylphenoxy) -1-piperidyl] benzyl group, 4- [4- (4-chlorophenoxy) -1-piperidyl] benzyl Group, 4- {4- [3,4-di (trifluoromethoxy) phenoxy] -1-piperidyl} benzyl group, 4- {4- [2,4,6-tri (trifluoromethyl) pheno Xyl] -1-piperidyl} benzyl group, 4- [4- (2,4-dichlorophenoxy) -1-piperidyl] benzyl group, 4- [4- (2,4,6-trifluorophenoxy) -1- Piperidyl] benzyl group, 3- [2,4-diphenoxy-3-piperidyl] benzyl group, 2- [1,2,3-triphenoxy-4-piperidyl] benzyl group, 4- [N-methyl-N- ( 4-trifluoromethoxycinnamyl) amino] -3- [4- (4-trifluoromethoxyphenoxy) -1-piperidyl] benzyl C1-6 alkyl group such as benzyl group [on the phenyl ring, 1 to 3 A piperidyl group (1 to 3 phenoxy groups on the piperidine ring [halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted on the phenyl ring) 1-5 from selected group the group consisting of C1~6 alkoxy group, preferably may be in 1-3 substituents] is assumed to be substituted) and group -NR ²⁴ R ²⁵ (R ²⁴ represents a hydrogen atom or a C1~6 alkyl group. R ²⁵ is a phenyl C2-6 alkenyl group [1-5 groups selected from unsubstituted or halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups, Preferred is a group composed of 1 or 2 phenyl groups substituted by 1 to 3 and an alkenyl group having 2 to 6 carbon atoms and 1 to 3 double bonds. And 1 to 3 groups selected from the group consisting of:

  A piperidyl C1-6 alkyl group (on the piperidine ring at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 And at least one group selected from the group consisting of alkoxy groups may be substituted.) For example, (4-phenyl-1-piperidyl) methyl group, 2 -(3-phenyl-2-piperidyl) ethyl group, 3- (2-phenyl-3-piperidyl) propyl group, 4- (1-phenyl-4-piperidyl) butyl group, 5- (4-phenyl-1- Piperidyl) pentyl, 6- (1-phenyl-2-piperidyl) hexyl, 1- (4-trifluoromethoxyphenyl) -4-piperidylmethyl, 1- (4-tri Fluoromethylphenyl) -4-piperidylmethyl group, 1- (3-methoxyphenyl) -4-piperidylmethyl group, 1- (2-methylphenyl) -4-piperidylmethyl group, 1- (4-chlorophenyl)- 4-piperidylmethyl group, 1- [3,4-di (trifluoromethoxy) phenyl] -4-piperidylmethyl group, 1- [2,4,6-tri (trifluoromethyl) phenyl] -4-piperidylmethyl Group, 1- (3,4-dimethylphenyl) -4-piperidylmethyl group, 1- (2,4,6-trimethoxyphenyl) -4-piperidylmethyl group, 1- (3,4-dichlorophenyl) -4 -Piperidylmethyl group, 1- (2,4,6-tribromophenyl) -4-piperidylmethyl group, (1,2,6-triphenyl-4-piperidyl) methyl group, , 4-diphenyl-1-piperidyl) methyl group and other piperidyl C1-6 alkyl groups (on the piperidine ring 1-3 phenyl groups (on the phenyl ring, halogen atoms, halogen-substituted or unsubstituted C1 A group selected from the group consisting of a -6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group, which may be substituted with 1 to 5, preferably 1 to 3 groups; ).

  Phenyl C1-6 alkyl group [on the phenyl ring, at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 As the substituent], it is assumed that at least one group selected from the group consisting of alkoxy groups is substituted, for example, 2- (2-fluorophenyl) benzyl group, 3- (3-fluorophenyl) benzyl group, 4- (4-fluorophenyl) benzyl group, 2- (2-chlorophenyl) benzyl group, 3- (3-chlorophenyl) benzyl group, 4- (4-chlorophenyl) benzyl group, 2- (2-bromophenyl) benzyl group, 3- (3-bromophenyl) benzyl group, 4- (4-bromophenyl) benzyl group, 2- 2-iodophenyl) benzyl group, 3- (3-iodophenyl) benzyl group, 4- (4-iodophenyl) benzyl group, 4- (2,3-difluorophenyl) benzyl group, 3- (3,4- Difluorophenyl) benzyl group, 2- (3,5-difluorophenyl) benzyl group, 4- (2,4-difluorophenyl) benzyl group, 3- (2,6-difluorophenyl) benzyl group, 2- (2, 3-dichlorophenyl) benzyl group, 4- (3,4-dichlorophenyl) benzyl group, 3- (3,5-dichlorophenyl) benzyl group, 2- (2,4-dichlorophenyl) benzyl group, 4- (2,6- Dichlorophenyl) benzyl group, 3- (2-fluoro-4-bromophenyl) benzyl group, 2- (4-chloro-3-fluorophenyl) benzyl group, 4 (2,3,4-trichlorophenyl) benzyl group, 3- (3,4,5-trifluorophenyl) benzyl group, 2- (2,4,6-trichlorophenyl) benzyl group, 4- (4-isopropyl) Phenyl) benzyl group, 3- (4-n-butylphenyl) benzyl group, 2- (4-methylphenyl) benzyl group, 4- (2-methylphenyl) benzyl group, 3- (3-methylphenyl) benzyl group 2- (2,4-dimethylphenyl) benzyl group, 4- (2,3-dimethylphenyl) benzyl group, 3- (2,6-dimethylphenyl) benzyl group, 2- (3,5-dimethylphenyl) Benzyl group, 4- (2,5-dimethylphenyl) benzyl group, 3- (2,4,6-trimethylphenyl) benzyl group, 2- (3,5-ditrifluoromethylphenyl) ben A dil group, 4- (2,3,4,5,6-pentafluorophenyl) benzyl group, 3- (4-isopropoxyphenyl) benzyl group, 2- (4-n-butoxyphenyl) benzyl group, 4- (4-methoxyphenyl) benzyl group, 3- (2-methoxyphenyl) benzyl group, 2- (3-methoxyphenyl) benzyl group, 4- (2,4-dimethoxyphenyl) benzyl group, 3- (2,3 -Dimethoxyphenyl) benzyl group, 2- (2,6-dimethoxyphenyl) benzyl group, 2- (3,5-dimethoxyphenyl) benzyl group, 4- (2,5-dimethoxyphenyl) benzyl group, 3- (2 , 4,6-trimethoxyphenyl) benzyl group, 2- (3,5-ditrifluoromethoxyphenyl) benzyl group, 4- (2-isopropoxyphenyl) benzyl group, -(3-chloro-4-methoxyphenyl) benzyl group, 2- (2-chloro-4-trifluoromethoxyphenyl) benzyl group, 4- (3-methyl-4-fluorophenyl) benzyl group, 3- (4 -Bromo-3-trifluoromethylphenyl) benzyl group, 4- (2-trifluoromethylphenyl) benzyl group, 3- (3-trifluoromethylphenyl) benzyl group, 4- (4-trifluoromethylphenyl) benzyl Group, 2- (2-pentafluoroethylphenyl) benzyl group, 3- (3-pentafluoroethylphenyl) benzyl group, 2- (4-pentafluoroethylphenyl) benzyl group, 4- (2-trifluoromethoxyphenyl) ) Benzyl group, 3- (3-trifluoromethoxyphenyl) benzyl group, 4- (4-trifluoromethoate) Ciphenyl) benzyl group, 4- (2-pentafluoroethoxyphenyl) benzyl group, 3- (3-pentafluoroethoxyphenyl) benzyl group, 2- (4-pentafluoroethoxyphenyl) benzyl group, 2- [4- ( 2-trifluoromethylphenyl) phenyl] ethyl group, 2- [3- (3-trifluoromethylphenyl) phenyl] ethyl group, 2- [2- (4-trifluoromethylphenyl) phenyl] ethyl group, 2- [4- (2-trifluoromethoxyphenyl) phenyl] ethyl group, 2- [3- (3-trifluoromethoxyphenyl) phenyl] ethyl group, 2- [2- (4-trifluoromethoxyphenyl) phenyl] ethyl Group, 2- [4- (2-pentafluoroethoxyphenyl) phenyl] ethyl group, 2- [3- (3-pentafluoroethoxyphenyl) Nyl) phenyl] ethyl group, 2- [2- (4-pentafluoroethoxyphenyl) phenyl] ethyl group, 3- [4- (2-trifluoromethylphenyl) phenyl] propyl group, 3- [3- (3 -Trifluoromethylphenyl) phenyl] propyl group, 3- [2- (4-trifluoromethylphenyl) phenyl] propyl group, 3- [4- (2-trifluoromethoxyphenyl) phenyl] propyl group, 3- [ 3- (3-trifluoromethoxyphenyl) phenyl] propyl group, 3- [2- (4-trifluoromethoxyphenyl) phenyl] propyl group, 3- [4- (3-pentafluoroethoxyphenyl) phenyl] propyl group , 3- [3- (4-pentafluoroethoxyphenyl) phenyl] propyl group, 4- [2- (3-pentafluoroethoxyphenyl) phenyl] Til group, 5- [4- (4-trifluoromethylphenyl) phenyl] pentyl group, 4- [3- (4-trifluoromethylphenyl) phenyl] pentyl group, 4- [2- (4-trifluoromethoxy) Phenyl) phenyl] pentyl group, 6- [4- (3-trifluoromethylphenyl) phenyl] hexyl group, 6- [3- (4-trifluoromethylphenyl) phenyl] hexyl group, 6- [2- (4 -Trifluoromethoxyphenyl) phenyl] hexyl group, 2,4-di (4-trifluoromethylphenyl) benzyl group, 2,4,6-tri (4-trifluoromethoxyphenyl) benzyl group and other alkyl moieties are carbon A phenylalkyl group that is a linear or branched alkyl group of 1 to 6 [on the phenyl ring, 1 to 3 phenyl groups (on the phenyl ring, a halogen atom 1 is a group selected from the group consisting of a halogen-substituted or unsubstituted linear or branched C1-6 alkyl group and a halogen-substituted or unsubstituted linear or branched C1-6 alkoxy group; To 5 and preferably 1 to 3 are substituted)].

  A piperazinyl C1-6 alkyl group (on the piperazine ring at least one phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 The group may be substituted with at least one group selected from the group consisting of alkoxy groups] may be substituted, for example, 1-piperazinylmethyl group, 1- (2-piperazinyl) Ethyl group, 2- (1-piperazinyl) ethyl group, 3- (1-piperazinyl) propyl group, 2- (1-piperazinyl) propyl group, 4- (2-piperazinyl) butyl group, 5- (2-piperazinyl) Pentyl group, 4- (1-piperazinyl) pentyl group, 6- (1-piperazinyl) hexyl group, 2-methyl-3- (1-piperazinyl) propyl group, 1,1 Dimethyl-2- (1-piperazinyl) ethyl group, (4-phenyl-1-piperazinyl) methyl group, (2,4-diphenyl-1-piperazinyl) methyl group, (2,4,5-triphenyl-1- Piperazinyl) methyl group, [4- (4-trifluoromethoxyphenyl) -1-piperazinyl] methyl group, [4- (4-trifluoromethylphenyl) -1-piperazinyl] methyl group, [4- (4-chlorophenyl) ) -1-piperazinyl] methyl group, [4- (2,4-dichlorophenyl) -1-piperazinyl] methyl group, [4- (2,4,6-trifluorophenyl) -1-piperazinyl] methyl group, [ 2,4-di (trifluoromethyl) phenyl-1-piperazinyl] methyl group, [2,4,6-tri (trifluoromethoxy) phenyl-1-pipera Nil] piperazinyl C1-6 alkyl group such as methyl group (on piperazine ring, 1 to 3 phenyl groups [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted) Or 1 to 5, preferably 1 to 3 groups selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted).

  Piperidyl C1-6 alkyl group (at least one phenoxy group on the piperidine ring [halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 on the phenyl ring) The group may be substituted with at least one group selected from the group consisting of alkoxy groups] may be substituted, for example, 1-piperidylmethyl group, 2- (2-piperidyl) ethyl group 3- (3-piperidyl) propyl group, 4- (4-piperidyl) butyl group, 5- (1-piperidyl) pentyl group, 6- (2-piperidyl) hexyl group, 1- (4-trifluoromethoxyphenoxy) ) -4-piperidylmethyl group, 1- (4-trifluoromethylphenoxy) -4-piperidylmethyl group, 2-methyl-3- (piperidin-1-yl) Propyl group, 1,1-dimethyl-2- (piperidin-1-yl) ethyl group, 1- (4-chlorophenoxy) -4-piperidylmethyl group, 1- [3,4-di (trifluoromethoxy) phenoxy ] -4-piperidylmethyl group, 1- [2,4,6-tri (trifluoromethoxy) phenoxy] -4-piperidylmethyl group, 1- (3,4-dichlorophenoxy) -4-piperidylmethyl group, 1 -(2,4,6-tribromophenoxy) -4-piperidylmethyl group, (1,2,6-triphenoxy-4-piperidyl) methyl group, (2,4-diphenoxy-1-piperidyl) methyl group, etc. A piperidyl C1-6 alkyl group (1-3 phenoxy groups on the piperidine ring [halogen atom, halogen-substituted or unsubstituted C1-6 alkyl on the phenyl ring) And 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted. Can be mentioned.

  A thiazolyl group [on the thiazole ring selected from the group consisting of a phenyl group (on the phenyl ring a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; At least one of the above groups may be substituted), piperazinyl C1-6 alkyl group (on the piperazine ring at least one phenyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted) At least one group selected from the group consisting of a C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] and piperidyl C1-6 An alkyl group (on the piperidine ring, at least one phenoxy group [on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 A group selected from the group consisting of an alkyl group optionally substituted with at least one group selected from the group consisting of an alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. As at least one of these may be substituted], for example, (2-, 4- or 5-) thiazolyl group, 2- (4-trifluoromethoxyphenyl) -5-thiazolyl group, 2- [4 -(4-trifluoromethoxyphenyl) -1-piperazinyl] methyl-5-thiazolyl group, 2- [4- (4-trifluoromethoxyphenoxy) -1-piperidyl] methyl-5-thiazolyl group, 2- [2 , 4-Di (trifluoromethoxy) phenyl] -5-thiazolyl group, 2- {4- [2,4-di (trifluoromethoxy) phenyl] -1-piperazinyl} methyl-5-thiazo 2- {4- [2,4-di (trifluoromethoxy) phenoxy] -1-piperidyl} methyl-5-thiazolyl group, 2- (4-trifluoromethylphenyl) -5-thiazolyl group, 2 -[4- (4-trifluoromethylphenyl) -1-piperazinyl] methyl-5-thiazolyl group, 2- [4- (4-trifluorotylphenoxy) -1-piperidyl] methyl-5-thiazolyl group, 2 -[2,4,6-tri (trifluoromethyl) phenyl] -5-thiazolyl group, 2- {4- [2,4,6-tri (trifluoromethyl) phenyl] -1-piperazinyl} methyl-5 -Thiazolyl group, 2- {4- [2,4,6-tri (trifluoromethyl) phenoxy] -1-piperidyl} methyl-5-thiazolyl group, 2- (4-chlorophenyl) -5-thia Zolyl group, 2- [4- (4-chlorophenyl) -1-piperazinyl] methyl-5-thiazolyl group, 2- [4- (2-chlorophenoxy) -1-piperidyl] methyl-5-thiazolyl group, 2- (2,4-dichlorophenyl) -5-thiazolyl group, 2- [4- (2,4-dichlorophenyl) -1-piperazinyl] methyl-5-thiazolyl group, 2- [4- (2,4-dichlorophenoxy) -1-piperidyl] methyl-5-thiazolyl group, 2- (2,4,6-trifluorophenyl) -5-thiazolyl group, 2- [4- (2,4,6-trifluorophenyl) -1- Piperazinyl] methyl-5-thiazolyl group, 2- [4- (2,4,6-trifluorophenoxy) -1-piperidyl] methyl-5-thiazolyl group, 2- (2,4-diphenoxy-1-pipe Dil) methyl-5-thiazolyl group, 5- (2,4,5-triphenoxy-1-piperidyl) methyl-2-thiazolyl group, 5- (2,4-diphenyl-1-piperazinyl) methyl-2-thiazolyl Group, a thiazolyl group such as 2- (2,4,5-triphenyl-1-piperazinyl) methyl-4-thiazolyl group, 4- (1-piperidyl) -2- (1-piperazinyl) -5-thiazolyl group [ On the thiazole ring, there is a phenyl group (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. 1-5, preferably 1-3 optionally substituted), piperazinyl C1-6 alkyl groups (on the piperazine ring 1-3 phenyl groups [on the phenyl ring halo 1 to 5, preferably 1 to 3 groups selected from the group consisting of a C atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group May be substituted) and a piperidyl C1-6 alkyl group (on the piperidine ring 1-3 phenoxy groups [on the phenyl ring a halogen atom, halogen-substituted or unsubstituted C1- 1 to 5, preferably 1 to 3 groups selected from the group consisting of 6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted) 1 to 2 groups selected from the group consisting of may be substituted].

  Benzoxazolyloxy group (on the benzoxazole ring, piperazinyl group [on the piperazine ring, phenyl C1-6 alkyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group And at least one group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted, and a phenyl C2-6 alkenyl group (on the phenyl ring, a halogen atom, a halogen A group selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group). At least one of them may be substituted], a piperidyl group [on the piperidine ring, a phenyl C1-6 alkyl group (phenyl On the top, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) And an amino group (on the amino group, a C1-6 alkyl group and a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy At least one group selected from the group consisting of groups may be substituted] At least one group selected from the group consisting of at least one group selected from the group consisting of The species may be substituted] and a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 For example, 2 or more groups selected from the group consisting of alkoxy groups may be substituted. At least one group selected from the group consisting of alkoxy groups may be substituted. -[4- (4-trifluoromethoxybenzyl) -1-piperazinyl] -6-benzoxazolyloxy group, 2-phenyl-5-benzoxazolyloxy group, 2- (4-chlorophenyl) -5 Benzoxazolyloxy group, 2- [4- (4-trifluoromethylbenzyl) -1-piperazinyl] -6-benzoxazolyloxy group, 2- [4- (4-chlorobenzyl) -1-piperazinyl ] -6-benzoxazolyloxy group, 2- {4- [2,4,6-tri (trifluoromethoxy) benzyl] -1-piperazinyl} -6-benzoxazolyloxy group, 2 -{4- [2,4-di (trifluoromethyl) benzyl] -1-piperazinyl} -6-benzoxazolyloxy group, 2- [4- (2,4-dichlorobenzyl) -1-piperazinyl] -6-benzoxazolyloxy group, 2- [4- (2,4,6-trifluorobenzyl) -1-piperazinyl] -6-benzoxazolyloxy group, 2- (4-benzyl-1- Piperazinyl) -4-benzoxazolyloxy group, 2- (2,4-dibenzyl-1-piperazinyl) -7-benzoxazolyloxy group, 2- (2,4,6-tribenzyl-1-piperazinyl) -6-benzoxazolyloxy group, 2- (4-trifluoromethoxyphenyl) -5-benzoxazolyloxy group, 2- (4-trifluoromethylphenyl) -5-benzoxazolyl Oxy group, 2- (2,4-dibromophenyl) -5-benzoxazolyloxy group, 2- (2,4,6-trichlorophenyl) -5-benzoxazolyloxy group, 2- [2, 4,6-tri (trifluoromethoxy) phenyl] -5-benzoxazolyloxy group, 2- [2,4-di (trifluoromethyl) phenyl] -5-benzoxazolyloxy group, 4-phenyl -5- (1-piperazinyl) -2-benzoxazolyloxy group, 2,4,5-triphenyl-7-benzoxazolyloxy group, 2- [4- (4-trifluoromethoxybenzyl) )-(1-, 2- or 3-) piperidyl]-(2-, 4-, 5-, 6- or 7-) benzoxazolyloxy group, 2- {4- [3- (4-tri Fluoromethylphenyl) -2-propenyl] (1-, 2- or 3-) piperazinyl}-(2-, 4-, 5-, 6- or 7-benzoxazolyloxy group, 4- [N-methyl-N- (4-chlorophenyl) amino ]-(1-, 2- or 3-) piperidyl]-(2-, 4-, 5-, 6- or 7-) benzoxazolyloxy groups such as benzoxazolyloxy groups (on the benzoxazole ring) A piperazinyl group [on the piperazine ring, a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy A linear group having 1 to 5, preferably 1 to 3 groups selected from the group consisting of groups and having 2 to 6 carbon atoms in the alkenyl moiety and 1 to 3 double bonds Or a branched alkenyl group A phenyl C2-6 alkenyl group including both a trans isomer and a cis isomer (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy A group selected from the group consisting of 1 to 5 groups, preferably 1 to 3 groups selected from the group consisting of groups) may be substituted], piperidyl Group [on the piperidine ring, a phenyl C1-6 alkyl group (on the phenyl ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] 1 to 5, preferably 1 to 3 groups selected from more than one group and an amino group (on the amino group, a C1-6 alkyl group and a phenyl group [on the phenyl ring) 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group Or 1 to 2 groups selected from the group consisting of 1 to 2 groups selected from the group] may be substituted] and a phenyl group (on the phenyl ring). Is substituted with 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups. It is assumed that 1 to 3 groups selected from the group consisting of (optionally) are substituted. ).

  Benzimidazolyloxy group (on the benzimidazole ring, a C1-6 alkyl group, a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of alkoxy groups may be substituted], a piperidyl group [at least one phenoxy group on the piperidine ring (halogen atom on the phenyl ring, halogen substitution or At least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]], piperazinyl Group [on the piperazine ring at least one phenyl C1-6 alkyl group (on the phenyl ring, Or at least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] and Phenyl C1-6 alkyl group [on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; The species may be substituted. At least one group selected from the group consisting of may be substituted) is, for example, (1-, 2-, 4-, 5-, 6- or 7-) Benzimidazolyloxy group, 2-phenyl-5-benzimidazolyloxy group, 1-methyl-5-benzimidazolyloxy group, 1-methyl-2-phenyl-5-benzimidazolyl Xyl group, 2- (4-chlorophenyl) -5-benzimidazolyloxy group, 1-methyl-2- (4-chlorophenyl) -5-benzimidazolyloxy group, 1,2-diphenyl-5-benzimidazolyloxy group, 1, 4 -Dimethyl-5-benzimidazolyloxy group, 1-methyl-2,6-diphenyl-5-benzimidazolyloxy group, 2- (4-trifluoromethylphenyl) -5-benzimidazolyloxy group, 1-methyl-2- (4 -Trifluoromethoxyphenyl) -5-benzimidazolyloxy group, 1,2,7-triphenyl-5-benzimidazolyloxy group, 1,2,4-trimethyl-5-benzimidazolyloxy group, 1-ethyl-2,6- Diphenyl-5-benzimidazolyloxy group, 2- [2,4-di (trif Fluoromethyl) phenyl] -5-benzimidazolyloxy group, 1-methyl-2- [2,4,6-tri (trifluoromethoxy) phenyl] -5-benzimidazolyloxy group, 2- (2,4-dichlorophenyl) -5 -Benzimidazolyloxy group, 2- (2,4,6-trifluorophenyl) -5-benzimidazolyloxy group, 2- (3-bromophenyl) -5-benzimidazolyloxy group, 2- (2-iodophenyl) -5 -Benzimidazolyloxy group, 2- [4-trifluoromethoxyphenoxy- (1-, 2- or 3-) piperidyl]-(1-, 4-, 5-, 6- or 7-) imidazolyloxy group, 1- Benzyl-2- [4-trifluoromethoxybenzyl- (1-, 2- or 3-) piperazinyl]-(4-, 5-, 6- or 7-) imidazolyloxy group, 1- (4-trifluoromethoxybenzyl)-(2-, 4-, 5-, 6- or 7-) imidazolyloxy group and other benzimidazolyloxy groups (on the benzimidazole ring, C1-6 alkyl group, phenyl group [on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. 1 to 5, preferably 1 to 3 may be substituted], piperidyl group [1 to 3 phenoxy groups on the piperidine ring (halogen atom, halogen-substituted or unsubstituted on the phenyl ring) 1 to 5, preferably 1 to 3, groups selected from the group consisting of C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted. May be substituted], a piperazinyl group [1-3 phenyl C1-6 alkyl groups on the piperazine ring (halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group on the phenyl ring) And 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted] and phenyl C1 -6 alkyl group [1-5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring. , Preferably 1 to 3 groups may be substituted] may be substituted with 1 to 3 groups selected from the group consisting of:

  1,2,3,4-tetrahydroisoquinolyl group (on the 1,2,3,4-tetrahydroisoquinoline ring, (m-1) amino group [on the amino group is a C1-6 alkyl group, phenyl Group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. And a phenyl C1-6 alkyl group (on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group). And at least one of the groups selected from the group consisting of: (m-2) a phenoxy group [having a halogen on the phenyl ring] original Or at least one group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]. Examples of the group may be substituted with (1-, 2-, 3-, 4-, 5-, 6-, 7- or 8-) 1,2,3. , 4-tetrahydroisoquinolyl group, 7- [N-methyl-N- (4-trifluoromethoxyphenyl) amino] -1,2,3,4-tetrahydro-2-isoquinolyl group, 7- [N-methyl -N- (4-trifluoromethoxybenzyl) amino] -1,2,3,4-tetrahydro-2-isoquinolyl group, 6- (4-trifluoromethoxyphenoxy) -1,2,3,4-tetrahydro- 2-Isoquinolyl , 7- [N-methyl-N- (4-trifluoromethylphenyl) amino] -1,2,3,4-tetrahydro-2-isoquinolyl group, 7- [N-methyl-N- (4-trifluoro) Mailyl) amino] -1,2,3,4-tetrahydro-2-isoquinolyl group, 6- (4-trifluoromethylphenoxy) -1,2,3,4-tetrahydro-2-isoquinolyl group, 7- [ N-methyl-N- (4-chlorophenyl) amino] -1,2,3,4-tetrahydro-2-isoquinolyl group, 7- [N- (4-chlorophenyl) amino] -1,2,3,4- Tetrahydro-2-isoquinolyl group, 7- [N-methyl-N- (4-chlorobenzyl) amino] -1,2,3,4-tetrahydro-2-isoquinolyl group, 7- [N- (4-chlorobenzyl) )amino -1,2,3,4-tetrahydro-2-isoquinolyl group, 6- (4-chlorociphenoxy) -1,2,3,4-tetrahydro-2-isoquinolyl group, 7- {N-methyl-N- [2,4-di (trifluoromethoxy) phenyl] amino} -1,2,3,4-tetrahydro-2-isoquinolyl group, 7- {N-methyl-N- [2,4,6-tri (tri Fluoromethoxy) benzyl] amino} -1,2,3,4-tetrahydro-2-isoquinolyl group, 6- [2,4-di (trifluoromethoxy) phenoxy] -1,2,3,4-tetrahydro-2 -Isoquinolyl group, 7- {N-methyl-N- [2,4,6-tri (trifluoromethyl) phenyl] amino} -1,2,3,4-tetrahydro-2-isoquinolyl group, 7- {N -Methyl-N- [2,4-di (Trifluoromethyl) benzyl] amino} -1,2,3,4-tetrahydro-2-isoquinolyl group, 6- [2,4,6-tri (trifluoromethyl) phenoxy] -1,2,3,4 -Tetrahydro-2-isoquinolyl group, 7- [N-methyl-N- (2,4-dibromophenyl) amino] -1,2,3,4-tetrahydro-2-isoquinolyl group, 7- [N-methyl- N- (2,3-diiodobenzyl) amino] -1,2,3,4-tetrahydro-2-isoquinolyl group, 6- (2,4,6-trifluorophenoxy) -1,2,3,4 -Tetrahydro-2-isoquinolyl group, 7-amino-6-phenoxy-1,2,3,4-tetrahydro-2-isoquinolyl group, 4,5,6-triphenoxy-1,2,3,4-tetrahydro- 7-Isoquinolyl 1,2,3,4-tetrahydroisoquinolyl group such as an amino group on the 1,2,3,4-tetrahydroisoquinoline ring [C1-6 alkyl group on the amino group, phenyl group (phenyl On the ring, there are 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. Each may be substituted) and a phenyl C1-6 alkyl group (on the phenyl ring, consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group) A group selected from the group consisting of 1 to 5 groups, preferably 1 to 3 groups selected from the group) may be substituted] and the phenoxy described above Group [F 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group on the nyl ring, preferably 1 to 1 to 3 of the groups selected from the group consisting of 3 which may be substituted] may be mentioned.

  A C1-6 alkoxy group substituted with two phenyl groups [on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] The group may be substituted with at least one kind of group such as 1,1-diphenylmethoxy group, 1,2-diphenylethoxy group, 3,3-diphenylpropoxy group, 3,4-diphenylbutoxy Group, 3,5-diphenylpentyloxy group, 4,6-diphenylhexyloxy group, 1,1-di (4-trifluoromethoxyphenyl) methoxy group, 1- (2-fluorophenyl) -1- (3- Fluorophenyl) methoxy group, 1- (4-fluorophenyl) -1- (2-chlorophenyl) methoxy group, 1- (3-chlorophene) L) -1- (4-chlorophenyl) methoxy group, 1- (2-bromophenyl) -1- (3-bromophenyl) methoxy group, 1- (4-bromophenyl) -2- (2-iodophenyl) Ethoxy group, 3- (3-iodophenyl) -3- (4-iodophenyl) propoxy group, 1- (2,3-difluorophenyl) -1- (3,4-difluorophenyl) methoxy group, 4- ( 3,5-difluorophenyl) -4- (2,4-difluorophenyl) butoxy group, 5- (2,6-difluorophenyl) -5- (2,3-dichlorophenyl) pentyloxy group, 6- (3 4-dichlorophenyl) -6- (3,5-dichlorophenyl) hexyloxy group, 1- (2,4-dichlorophenyl) -1- (2,6-dichlorophenyl) methoxy group, 1- (3 4,5-trifluorophenyl) -1- (3,4,5-trichlorophenyl) methoxy group, 1- (2,3,4,5,6-pentafluorophenyl) -1- (2,4,6 -Trimethylphenyl) methoxy group, 1- (4-n-butylphenyl) -1- (2,4-dimethylphenyl) methoxy group, 1- (3,5-ditrifluoromethylphenyl) -1- (4-n -Butoxyphenyl) methoxy group, 1- (2,4-dimethoxyphenyl) -1- (2,3-dimethoxyphenyl) methoxy group, 1- (2,4,6-trimethoxyphenyl) -1- (3 5-ditrifluoromethoxyphenyl) methoxy group, 1- (3-chloro-4-methoxyphenyl) -1- (2-chloro-4-trifluoromethoxyphenyl) methoxy group, 1- (3-methyl-4-fluoro) Rophenyl) -1- (4-bromo-3-trifluoromethylphenyl) methoxy group, 1- (2-methylphenyl) -1- (3-methylphenyl) methoxy group, 1- (2-pentafluoroethylphenyl) -1- (3-pentafluoroethylphenyl) methoxy group, 1- (2-isopropylphenyl) -1- (2-tert-butylphenyl) methoxy group, 1- (2-sec-butylphenyl) -1- ( 2-n-heptafluoropropylphenyl) methoxy group, 1- (4-pentylphenyl) -1- (4-hexylphenyl) methoxy group, 1- (2-methoxyphenyl) -1- (2,6-dimethoxyphenyl) ) Methoxy group, 1- (2-pentafluoroethoxyphenyl) -1- (isopropoxyphenyl) methoxy group, 1- (2-tert-butyl) Xylphenyl) -1- (2-sec-butoxyphenyl) methoxy group, 1- (2-n-heptafluoropropoxyphenyl) -1- (4-n-pentoxyphenyl) methoxy group, 1,1-di (4 -N-hexyloxyphenyl) C1-6 alkoxy group substituted with two phenyl groups such as methoxy group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted 1 to 5 groups, preferably 1 to 3 groups selected from the group consisting of C1-6 alkoxy groups may be used.

  Phenyl C1-6 alkyl group [on the phenyl ring, at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1- As the substituent], at least one group selected from the group consisting of 6 alkoxy groups may be substituted, for example, 4-phenylbenzyl group, 3-phenylbenzyl group, 2 -Phenylbenzyl group, 2,4-diphenylbenzyl group, 2,4,6-triphenylbenzyl group, 4- (4-trifluoromethoxyphenyl) benzyl group, 2- (3-trifluoromethylphenyl) benzyl group, 4- (2-fluorophenyl) benzyl group, 3- (4-chlorophenyl) benzyl group, 4- (4-methoxyphenyl) benzyl group, 3- 4-methylphenyl) benzyl group, 2- (3,4-dimethoxyphenyl) benzyl group, 4- (3,4-dimethylphenyl) benzyl group, 3- (3,4,6-trimethoxyphenyl) benzyl group, 2- (2,4,5-trimethylphenyl) benzyl group, 4- (3,4-dichlorophenyl) benzyl group, 2- (2,4,6-trifluorophenyl) benzyl group, 4- (3-chloro- 4-trifluoromethoxyphenyl) benzyl group, 2- [4- (2-fluorophenyl) phenyl] ethyl group, 3- [2- (3,4-dimethoxyphenyl) phenyl] propyl group, 4- [2- ( 2,4,5-trimethylphenyl) phenyl] butyl group, 5- [4- (3-chloro-4-trifluoromethoxyphenyl) phenyl] pentyl group, 6- [2- (3-tri A phenyl in which the alkyl moiety such as a fluoromethylphenyl) phenyl] hexyl group or 1- [4- (4-trifluoromethoxyphenyl) phenyl] ethyl group is a linear or branched alkyl group having 1 to 6 carbon atoms C1-6 alkyl group [on the phenyl group ring, 1 to 3 phenyl groups (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 1 to 5, preferably 1 to 3 groups selected from the group consisting of 6 alkoxy groups may be substituted.].

A piperidyl group (on the piperidine ring, an (n-1) phenyl group [on the phenyl ring, at least one group —NR ²⁶ R ²⁷ (R ²⁶ represents a hydrogen atom or a C 1-6 alkyl group; R ²⁷ represents a phenyl group [on the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; Is substituted)], (n-2) group -W ₁ NR ²⁸ R ²⁹ [W ₁ is a C1-6 alkylene group, R ²⁸ is R ²⁹ represents a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy; Fewer groups selected from the group consisting of groups And (n-3) a C1-6 alkoxy group substituted with two phenyl groups [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1. -6 alkyl group and at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] and (n-4) phenyl C1-6 alkyl group [phenyl On the base ring, at least one phenyl group (on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one of the groups selected from the group consisting of: a group selected from the group consisting of: 1-2 -, 3- or 4-) piperidyl group, 4- [N-methyl-N- (4-trifluoromethoxyphenyl) amino] phenyl-1-piperidyl group, 4- [N- (4-trifluoromethoxyphenyl) Aminomethyl] -1-piperidyl group, 4- [N-methyl-N- (4-trifluoromethoxyphenyl) aminomethyl] -1-piperidyl group, 4- [N-ethyl-N- (4-trifluoromethoxy) Phenyl) aminomethyl] -1-piperidyl group, 4- [1,1-di (4-trifluoromethoxyphenyl) methoxy] -1-piperidyl group, 4- [N-methyl-N- (4-trifluoromethyl) Phenyl) amino] phenyl-1-piperidyl group, 4- [N- (4-trifluoromethylphenyl) aminomethyl] -1-piperidyl group, 4- {N-methyl-N- [ , 4-Di (trifluoromethyl) phenyl] aminomethyl} -1-piperidyl group, 4- {N-ethyl-N- [2,4,6-tri (trifluoromethoxy) phenyl] aminomethyl} -1- Piperidyl group, 4- [1,1-di (4-trifluoromethylphenyl) methoxy] -1-piperidyl group, 4- [N-methyl-N- (4-chlorophenyl) amino] phenyl-1-piperidyl group, 4- [N- (2,4-dibromophenyl) aminomethyl] -1-piperidyl group, 4- [N-methyl-N- (2,4,6-trifluorophenyl) aminomethyl] -1-piperidyl group 4- [N-ethyl-N- (4-chlorophenyl) aminomethyl] -1-piperidyl group, 4- [1,1-di (4-chlorophenyl) methoxy] -1-piperidyl group, 4- [N- Me Ru-N- (2,4-dibromophenyl) amino] phenyl-1-piperidyl group, 4- [1,1-di (2,4-dibromophenyl) methoxy] -1-piperidyl group, 4- [N- Methyl-N- (2,4,6-trifluorophenyl) amino] phenyl-1-piperidyl group, 4- [1,1-di (2,4,6-trifluorophenyl) methoxy] -1-piperidyl 4- {N-methyl-N- [2,4-di (trifluoromethyl) phenyl] amino} phenyl-1-piperidyl group, 4- {N-methyl-N- [2,4,6-tri (Trifluoromethoxy) phenyl] amino} phenyl-1-piperidyl group, 4- {1- [2,4-di (trifluoromethyl) phenyl] -1- [2,4,6-tri (trifluoromethoxy) Phenyl] methoxy} -1-pi Peridyl group, 4- [N- (4-trifluoromethoxyphenyl) aminomethyl] -3- [N- (4-trifluoromethylphenyl) aminomethyl] -1-piperidyl group, 3,4,6-tri ( Piperidyl groups such as 1,1-diphenylmethoxy) -1-piperidyl group, 4- (4-phenylbenzyl)-(1-, 2- or 3-) piperidyl group (on the piperidine ring, (n-1) Phenyl group [on the phenyl ring, 1 to 3 groups —NRNR ²⁶ R ²⁷ (R ²⁶ represents a hydrogen atom or a C 1-6 alkyl group. R ²⁷ represents a phenyl group [on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C 1-6 alkyl group and a halogen-substituted or unsubstituted C 1-6 alkoxy group is 1 to 5 may be substituted, preferably 1 to 3]. ) Is substituted. ] Indicates the (n-2) group _{^{-W 1 NR 28 R 29 [W}} 1 is C1~6 alkylene group. R ²⁸ represents a hydrogen atom or a C 1-6 alkyl group. R ²⁹ is a phenyl group (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C 1-6 alkyl group and a halogen-substituted or unsubstituted C 1-6 alkoxy group is 1 to 5 may be substituted, preferably 1 to 3). ], A C1-6 alkoxy group substituted with two (n-3) phenyl groups [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 1 to 5, preferably 1 to 3 groups selected from the group consisting of alkoxy groups may be substituted] and (n-4) phenyl C1-6 alkyl groups [on the phenyl group ring, 1 ~ 3 phenyl groups (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is 1 to A group selected from the group consisting of 5 and preferably 1 to 3 substituents) may be substituted). .

  A C1-6 alkyl group substituted with two phenyl groups [on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] As the at least one kind of the group may be substituted], for example, 1,1-diphenylmethyl group, 1,2-diphenylethyl group, 3,3-diphenylpropyl group, 3,4-diphenylyl Group, 3,5-diphenylpentyl group, 4,6-diphenylhexyl group, 1,1-di (4-trifluoromethoxyphenyl) methyl group, 1,1-di (4-chlorophenyl) methyl group, 1- ( 2-fluorophenyl) -1- (3-fluorophenyl) methyl group, 1- (4-fluorophenyl) -1- (2-chlorophenyl) methyl group, 1- (3 Chlorophenyl) -1- (4-chlorophenyl) methyl group, 1- (2-bromophenyl) -1- (3-bromophenyl) methyl group, 1- (4-bromophenyl) -2- (2-iodophenyl) Ethyl group, 3- (3-iodophenyl) -3- (4-iodophenyl) propyl group, 1- (2,3-difluorophenyl) -1- (3,4-difluorophenyl) methyl group, 4- ( 3,5-difluorophenyl) -4- (2,4-difluorophenyl) butyl group, 5- (2,6-difluorophenyl) -5- (2,3-dichlorophenyl) pentyl group, 6- (3,4 -Dichlorophenyl) -6- (3,5-dichlorophenyl) hexyl group, 1- (2,4-dichlorophenyl) -1- (2,6-dichlorophenyl) methyl group, 1- (3,4,5-tri Fluorophenyl) -1- (3,4,5-trichlorophenyl) methyl group, 1- (2,3,4,5,6-pentafluorophenyl) -1- (2,4,6-trimethylphenyl) methyl group 1- (4-n-butylphenyl) -1- (2,4-dimethylphenyl) methyl group, 1- (3,5-ditrifluoromethylphenyl) -1- (4-n-butoxyphenyl) methyl group 1- (2,4-dimethoxyphenyl) -1- (2,3-dimethoxyphenyl) methyl group, 1- (2,4,6-trimethoxyphenyl) -1- (3,5-ditrifluoromethoxyphenyl) ) Methyl group, 1- (3-chloro-4-methoxyphenyl) -1- (2-chloro-4-trifluoromethoxyphenyl) methyl group, 1- (3-methyl-4-fluorophenyl) -1- ( 4-bro Mo-3-trifluoromethylphenyl) methyl group, 1- (2-methylphenyl) -1- (3-methylphenyl) methyl group, 1- (2-pentafluoroethylphenyl) -1- (3-pentafluoro Ethylphenyl) methyl group, 1- (2-isopropylphenyl) -1- (2-tert-butylphenyl) methyl group, 1- (2-sec-butylphenyl) -1- (2-n-heptafluoropropylphenyl) ) Methyl group, 1- (4-n-pentylphenyl) -1- (4-n-hexylphenyl) methyl group, 1- (2-methoxyphenyl) -1- (2,6-dimethoxyphenyl) methyl group, 1- (2-pentafluoroethoxyphenyl) -1- (isopropoxyphenyl) methyl group, 1- (2-tert-butoxyphenyl) -1- (2-sec- Toxiphenyl) methyl group, 1- (2-n-heptafluoropropoxyphenyl) -1- (4-n-pentoxyphenyl) methyl group, 1,1-di (4-n-hexyloxyphenyl) methyl group, etc. A C1-6 alkyl group substituted with two phenyl groups of [from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring] 1 to 5, preferably 1 to 3 selected groups may be substituted].

  A phenoxy group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. Is a substituent selected from the group consisting of the above-defined halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups, and halogen-substituted or unsubstituted C1-6 alkoxy groups. A phenoxy group having ˜5, preferably 1-3, such as 2-fluorophenoxy group, 3-fluorophenoxy group, 4-fluorophenoxy group, 2-chlorophenoxy group, 3-chlorophenoxy group, 4 -Chlorophenoxy group, 2-bromophenoxy group, 3-bromophenoxy group, 4-bromophenoxy group, 2-io Dophenoxy group, 3-iodophenoxy group, 4-iodophenoxy group, 2,3-difluorophenoxy group, 3,4-difluorophenoxy group, 3,5-difluorophenoxy group, 2,4-difluorophenoxy group, 2, 6-difluorophenoxy group, 2,3-dichlorophenoxy group, 3,4-dichlorophenoxy group, 3,5-dichlorophenoxy group, 2,4-dichlorophenoxy group, 2,6-dichlorophenoxy group, 3,4, 5-trifluorophenoxy group, 3,4,5-trichlorophenoxy group, 2,4,6-trifluorophenoxy group, 2,4,6-trichlorophenoxy group, 2-fluoro-4-bromophenoxy group, 4- Chloro-3-fluorophenoxy group, 2,3,4-trichlorophenoxy group, 3,4,5-trifluoropheno Si group, 2,3,4,5,6-pentafluorophenoxy group, 2,4,6-trimethylphenoxy group, 4-n-butylphenoxy group, 2,4-dimethylphenoxy group, 2,3-dimethylphenoxy group Group, 2,6-dimethylphenoxy group, 3,5-dimethylphenoxy group, 2,5-dimethylphenoxy group, 3,5-ditrifluoromethylphenoxy group, 4-n-butoxyphenoxy group, 2,4-dimethoxyphenoxy group Group, 2,3-dimethoxyphenoxy group, 2,6-dimethoxyphenoxy group, 3,5-dimethoxyphenoxy group, 2,5-dimethoxyphenoxy group, 2,4,6-trimethoxyphenoxy group, 3,5-ditri Fluoromethoxyphenoxy group, 3-chloro-4-methoxyphenoxy group, 2-chloro-4-trifluoromethoxyphenoxy Group, 3-methyl-4-fluorophenoxy group, 4-bromo-3-trifluoromethylphenoxy group, 2-methylphenoxy group, 3-methylphenoxy group, 4-methylphenoxy group, 2-methyl-3-chlorophenoxy group Group, 3-methyl-4-chlorophenoxy group, 2-chloro-4-methylphenoxy group, 2-methyl-3-fluorophenoxy group, 2-trifluoromethylphenoxy group, 3-trifluoromethylphenoxy group, 4- Trifluoromethylphenoxy group, 2-pentafluoroethylphenoxy group, 3-pentafluoroethylphenoxy group, 4-pentafluoroethylphenoxy group, 2-isopropylphenoxy group, 3-isopropylphenoxy group, 4-isopropylphenoxy group, 2- tert-Butylphenoxy group, 3-tert Butylphenoxy group, 4-tert-butylphenoxy group, 2-sec-butylphenoxy group, 3-sec-butylphenoxy group, 4-sec-butylphenoxy group, 2-n-heptafluoropropylphenoxy group, 3-n- Heptafluoropropylphenoxy group, 4-n-heptafluoropropylphenoxy group, 4-n-pentylphenoxy group, 4-n-hexylphenoxy group, 2-methoxyphenoxy group, 3-methoxyphenoxy group, 4-methoxyphenoxy group, 3-chloro-2-methoxyphenoxy group, 2-fluoro-3-methoxyphenoxy group, 2-fluoro-4-methoxyphenoxy group, 2,6-dimethoxyphenoxy group, 2,3,4-trifluorophenoxy group, 2 , 4,6-trifluorophenoxy group, 2-trifluoromethyl Xyphenoxy group, 3-trifluoromethoxyphenoxy group, 4-trifluoromethoxyphenoxy group, 3-fluoro-2-trifluoromethoxyphenoxy group, 2-fluoro-3-trifluoromethoxyphenoxy group, 3-fluoro-4- Trifluoromethoxyphenoxy group, 3-chloro-2-trifluoromethoxyphenoxy group, 2-chloro-3-trifluoromethoxyphenoxy group, 3-chloro-4-trifluoromethoxyphenoxy group, 2-pentafluoroethoxyphenoxy group, 3-pentafluoroethoxyphenoxy group, 4-pentafluoroethoxyphenoxy group, 3-chloro-2-pentafluoroethoxyphenoxy group, 2-chloro-3-pentafluoroethoxyphenoxy group, 3-chloro-4-pentafluoroethoxyphene Noxy group, 2-isopropoxyphenoxy group, 3-isopropoxyphenoxy group, 4-isopropoxyphenoxy group, 2-tert-butoxyphenoxy group, 3-tert-butoxyphenoxy group, 4-tert-butoxyphenoxy group, 2- sec-butoxyphenoxy group, 3-sec-butoxyphenoxy group, 4-sec-butoxyphenoxy group, 2-n-heptafluoropropoxyphenoxy group, 3-n-heptafluoropropoxyphenoxy group, 4-n-heptafluoropropoxyphenoxy group Group, 4-n-pentoxyphenoxy group, 4-n-hexyloxyphenoxy group and the like.

  Phenyl C1-6 alkyl group [on the phenyl ring, at least one phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 As the substituent], for example, a 4- (4-trifluoromethoxyphenyl) benzyl group, a group selected from the group consisting of alkoxy groups is substituted) 2,4-di (4-trifluoromethoxyphenyl) benzyl group, 2- (3-trifluoromethylphenoxy) benzyl group, 4- (2-fluorophenoxy) benzyl group, 2,4,6-tri (2- Fluorophenoxy) benzyl group, 3- (4-chlorophenoxy) benzyl group, 4- (4-methoxyphenoxy) benzyl group, 3- (4- Tilphenoxy) benzyl group, 2- (3,4-dimethoxyphenoxy) benzyl group, 4- (3,4-dimethylphenoxy) benzyl group, 3- (3,4,6-trimethoxyphenoxy) benzyl group, 2- (2,4,5-trimethylphenoxy) benzyl group, 4- (3,4-dichlorophenoxy) benzyl group, 2- (2,4,6-trifluorophenoxy) benzyl group, 4- (3-chloro-4 -Trifluoromethoxyphenoxy) benzyl group, 2- [4- (2-fluorophenoxy) phenyl] ethyl group, 3- [2- (3,4-dimethoxyphenoxy) phenyl] propyl group, 4- [2- (2 , 4,5-trimethylphenoxy) phenyl] butyl group, 5- [4- (3-chloro-4-trifluoromethoxyphenoxy) phenyl] pentyl group, 6 A linear or branched alkyl group having 1 to 6 carbon atoms such as [2- (3-trifluoromethylphenoxy) phenyl] hexyl group and 1- [4- (4-trifluoromethoxyphenoxy) phenyl] ethyl group A phenyl C1-6 alkyl group which is an alkyl group [on the phenyl ring, 1 to 3 phenoxy groups (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or It is assumed that 1 to 3 groups selected from the group consisting of unsubstituted C1-6 alkoxy groups are substituted.].

  Examples of the thiazolyl group (at least one phenyl group may be substituted on the thiazole ring) include, for example, (2-, 4- or 5-) thiazolyl group, 2-phenyl- (4- or 5 -) Thiazolyl group, 4-phenyl- (2- or 5-) thiazolyl group, 5-phenyl- (2- or 4-) thiazolyl group, 2,5-diphenyl-4-thiazolyl group, 2,4-diphenyl- Examples include thiazolyl groups such as 5-thiazolyl group and 4,5-diphenyl-2-thiazolyl group (on the thiazole ring, 1 to 2 phenyl groups may be substituted).

  Phenoxy C1-6 alkyl group (on phenyl ring, phenyl group (on phenyl ring, consisting of halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group) Selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. Examples of the phenoxy C1-6 alkyl group (halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group, and halogen-substituted or unsubstituted C1) In addition, at least one group selected from the group consisting of ˜6 alkoxy groups may be substituted), 4 Phenylphenoxymethyl group, 3-phenylphenoxymethyl group, 2-phenylphenoxymethyl group, 2,4-diphenylphenoxymethyl group, 2,4,6-triphenylphenoxymethyl group, 4- (4-trifluoromethoxyphenyl) Phenoxymethyl group, 2- (3-trifluoromethylphenyl) phenoxymethyl group, 4- (2-fluorophenyl) phenoxymethyl group, 3- (4-chlorophenyl) phenoxymethyl group, 4- (4-methoxyphenyl) phenoxy Methyl group, 3- (4-methylphenyl) phenoxymethyl group, 2- (3,4-dimethoxyphenyl) phenoxymethyl group, 4- (3,4-dimethylphenyl) phenoxymethyl group, 3- (3,4, 6-trimethoxyphenyl) phenoxymethyl group, 2- (2,4,5- Limethylphenyl) phenoxymethyl group, 4- (3,4-dichlorophenyl) phenoxymethyl group, 2- (2,4,6-trifluorophenyl) phenoxymethyl group, 4- (3-chloro-4-trifluoromethoxy) Phenyl) phenoxymethyl group, 2- (4-phenylphenoxy) ethyl group, 2- [4- (2-fluorophenyl) phenoxy] ethyl group, 3- [2- (3,4-dimethoxyphenyl) phenoxy] propyl group 4- [2- (2,4,5-trimethylphenyl) phenoxy] butyl group, 5- [4- (3-chloro-4-trifluoromethoxyphenyl) phenoxy] pentyl group, 6- [2- (3 -Trifluoromethylphenyl) phenoxy] hexyl group, 2- [4- (4-trifluoromethylphenyl) phenoxy] ethyl group, 2 -[4- (4-Trifluoromethoxyphenyl) phenoxy] phenoxy C1-6 alkyl group in which the alkyl moiety such as ethyl group is a linear or branched alkyl group having 1 to 6 carbon atoms (on the phenyl ring) A phenyl group (on the phenyl ring, 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group, Preferably 1 to 3 groups), a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. ~ 3 may be substituted).

  Phenyl C2-6 alkenyl group [on the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group The species is substituted] means 1 to 5, preferably 1 to 3, groups selected from a halogen atom, a halogen C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. This is a group composed of 1 or 2 substituted phenyl groups and an alkenyl group having 2 to 6 carbon atoms and 1 to 3 double bonds. The phenyl C2-6 alkenyl group includes both trans and cis isomers. Examples of such phenyl C2-6 alkenyl group include 3- (2-fluorophenyl) -2-propenyl group, 3,3-di (2-fluorophenyl) -2-propenyl group, 3- (3- Fluorophenyl) -2-propenyl group, 3- (4-fluorophenyl) -2-propenyl group, 3- (2,3-difluorophenyl) -2-propenyl group, 3- (2,3,4,5, 6-pentafluorophenyl) -2-propenyl group, 3- (2,4-difluorophenyl) -2-propenyl group, 3- (3,4-difluorophenyl) -2-propenyl group, 3- (3,5 -Difluorophenyl) -2-propenyl group, 3- (2-chlorophenyl) -2-propenyl group, 3- (3-chlorophenyl) -2-propenyl group, 3- (4-chlorophenyl) -2-propyl Penyl group, 3- (2,3-dichlorophenyl) -2-propenyl group, 3- (2,4-dichlorophenyl) -2-propenyl group, 3- (3,4-dichlorophenyl) -2-propenyl group, 3- (3,5-dichlorophenyl) -2-propenyl group, 3- (2-bromophenyl) -2-propenyl group, 3- (3-bromophenyl) -2-propenyl group, 3- (4-bromophenyl)- 2-propenyl group, 3- (2-methylphenyl) -2-propenyl group, 3- (3-methylphenyl) -2-propenyl group, 3- (4-methylphenyl) -2-propenyl group, 3- ( 2-trifluoromethylphenyl) -2-propenyl group, 3- (2-fluoro-4-bromophenyl) -2-propenyl group, 3- (4-chloro-3-fluorophenyl) -2-propenyl group Group, 3- (2,3,4-trichlorophenyl) -2-propenyl group, 3- (2,4,6-trichlorophenyl) -2-propenyl group, 3- (4-isopropylphenyl) -2- Propenyl group, 3- (4-n-butylphenyl) -2-propenyl group, 3- (2,4-dimethylphenyl) -2-propenyl group, 3- (2,3-dimethylphenyl) -2-propenyl group 3- (2,6-dimethylphenyl) -2-propenyl group, 3- (3,5-dimethylphenyl) -2-propenyl group, 3- (2,5-dimethylphenyl) -2-propenyl group, 3 -(2,4,6-trimethylphenyl) -2-propenyl group, 3- (3,5-ditrifluoromethylphenyl) -2-propenyl group, 3- (4-n-butoxyphenyl) -2-propenyl group , 3- (2 , 4-Dimethoxyphenyl) -2-propenyl group, 3- (2,3-dimethoxyphenyl) -2-propenyl group, 3- (2,6-dimethoxyphenyl) -2-propenyl group, 3- (3,5 -Dimethoxyphenyl) -2-propenyl group, 3- (2,5-dimethoxyphenyl) -2-propenyl group, 3- (3,5-ditrifluoromethoxyphenyl) -2-propenyl group, 3- (3-chloro -4-methoxyphenyl) -2-propenyl group, 3- (2-chloro-4-trifluoromethoxyphenyl) -2-propenyl group, 3- (3-methyl-4-fluorophenyl) -2-propenyl group, 3- (4-bromo-3-trifluoromethylphenyl) -2-propenyl group, 3- (3-trifluoromethylphenyl) -2-propenyl group, 3- (4-trifluoro Romethylphenyl) -2-propenyl group, 3- (2-trifluoromethoxyphenyl) -2-propenyl group, 3- (3-trifluoromethoxyphenyl) -2-propenyl group, 3- (4-trifluoromethoxy) Phenyl) -2-propenyl group, 3- (2-methoxyphenyl) -2-propenyl group, 3- (3-methoxyphenyl) -2-propenyl group, 3- (4-methoxyphenyl) -2-propenyl group, 3- (3,4-dimethoxyphenyl) -2-propenyl group, 3- (3,5-dimethoxyphenyl) -2-propenyl group, 4- (4-chlorophenyl) -2-butenyl group, 4- (4- Chlorophenyl) -3-butenyl group, 5- (4-chlorophenyl) -2-pentenyl group, 5- (4-chlorophenyl) -4-pentenyl group, 5- (4-chloro) Phenyl) -3-pentenyl group, 6- (4-chlorophenyl) -5-hexenyl group, 6- (4-chlorophenyl) -4-hexenyl group, 6- (4-chlorophenyl) -3-hexenyl group, 6- ( And 4-chlorophenyl) -3-hexenyl group.

  An imidazolyl group [consisting of at least one phenyl group on the imidazole ring (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) The at least one group selected from the group may be substituted) may be substituted, for example, (1-, 2-, 4- or 5-) imidazolyl group, 1-phenyl 2-imidazolyl group, 2- (2-fluorophenyl) -1-imidazolyl group, 4- (3-fluorophenyl) -2-imidazolyl group, 5- (4-fluorophenyl) -3-imidazolyl group, 1- (2-chlorophenyl) -3-imidazolyl group, 2- (3-chlorophenyl) -5-imidazolyl group, 1- (4-chlorophenyl) -2-imidazolyl group 4- (2-bromophenyl) -5-imidazolyl group, 5- (3-bromophenyl) -2-imidazolyl group, 1- (4-bromophenyl) -3-imidazolyl group, 2- (2-iodophenyl) -4-imidazolyl group, 4- (3-iodophenyl) -5-imidazolyl group, 5- (4-iodophenyl) -1-imidazolyl group, 1- (2,3-difluorophenyl) -2-imidazolyl group, 1- (3,4-difluorophenyl) -2-imidazolyl group, 1- (3,5-difluorophenyl) -2-imidazolyl group, 1- (2,4-difluorophenyl) -4-imidazolyl group, 1- (2,6-difluorophenyl) -5-imidazolyl group, 1- (2,3-dichlorophenyl) -2-imidazolyl group, 1- (3,4-dichloropheni) -4-imidazole Lyl group, 1- (3,5-dichlorophenyl) -5-imidazolyl group, 1- (2,4-dichlorophenyl) -2-imidazolyl group, 1- (2,6-dichlorophenyl) -4-imidazolyl group, 1- (3,4,5-trifluorophenyl) -5-imidazolyl group, 1- (3,4,5-trichlorophenyl) -2-imidazolyl group, 1- (2,4,6-trifluorophenyl) -4 -Imidazolyl group, 1- (2,4,6-trichlorophenyl) -5-imidazolyl group, 1- (2-fluoro-4-bromophenyl) -2-imidazolyl group, 1- (4-chloro-3-fluoro) Phenyl) -4-imidazolyl group, 1- (2,3,4-trichlorophenyl) -5-imidazolyl group, 1- (2,3,4,5,6-pentafluorophenyl) -2-imidazolyl Group, 1- (2,4,6-trimethylphenyl) -2-imidazolyl group, 2- (4-n-butylphenyl) -4-imidazolyl group, 4- (2,4-dimethylphenyl) -1-imidazolyl Groups, 5- (2,3-dimethylphenyl) -2-imidazolyl group, 1- (2,6-dimethylphenyl) -4-imidazolyl group, 2- (3,5-dimethylphenyl) -5-imidazolyl group, 4- (2,5-dimethylphenyl) -1-imidazolyl group, 5- (3,5-ditrifluoromethylphenyl) -2-imidazolyl group, 1- (4-n-butoxyphenyl) -2-imidazolyl group, 1- (2,4-dimethoxyphenyl) -2-imidazolyl group, 1- (2,3-dimethoxyphenyl) -2-imidazolyl group, 1- (2,6-dimethoxyphenyl) -2-imidazolyl Group, 2- (3,5-dimethoxyphenyl) -4-imidazolyl group, 4- (2,5-dimethoxyphenyl) -1-imidazolyl group, 5- (2,4,6-trimethoxyphenyl) -2 -Imidazolyl group, 1- (3,5-ditrifluoromethoxyphenyl) -2-imidazolyl group, 1- (3-chloro-4-methoxyphenyl) -2-imidazolyl group, 1- (2-chloro-4-tri Fluoromethoxyphenyl) -2-imidazolyl group, 1- (3-methyl-4-fluorophenyl) -2-imidazolyl group, 1- (4-bromo-3-trifluoromethylphenyl) -2-imidazolyl group, 1- (2-methylphenyl) -2-imidazolyl group, 2- (3-methylphenyl) -4-imidazolyl group, 4- (4-methylphenyl) -5-imidazolyl group, 5 (2-methyl-3-chlorophenyl) -1-imidazolyl group, 1- (3-methyl-4-chlorophenyl) -2-imidazolyl group, 2- (2-chloro-4-methylphenyl) -4-imidazolyl group, 4- (2-methyl-3-fluorophenyl) -5-imidazolyl group, 5- (2-trifluoromethylphenyl) -1-imidazolyl group, 1- (3-trifluoromethylphenyl) -2-imidazolyl group, 2- (4-trifluoromethylphenyl) -4-imidazolyl group, 4- (2-pentafluoroethylphenyl) -5-imidazolyl group, 5- (3-pentafluoroethylphenyl) -1-imidazolyl group, 1- (4-pentafluoroethylphenyl) -2-imidazolyl group, 2- (2-isopropylphenyl) -4-imidazolyl group, 4- (3 -Isopropylphenyl) -5-imidazolyl group, 5- (4-isopropylphenyl) -1-imidazolyl group, 1- (2-tert-butylphenyl) -2-imidazolyl group, 2- (3-tert-butylphenyl) -4-imidazolyl group, 4- (4-tert-butylphenyl) -5-imidazolyl group, 5- (2-sec-butylphenyl) -1-imidazolyl group, 1- (3-sec-butylphenyl) -2 -Imidazolyl group, 2- (4-sec-butylphenyl) -4-imidazolyl group, 4- (2-n-heptafluoropropylphenyl) -5-imidazolyl group, 5- (3-n-heptafluoropropylphenyl) -1-imidazolyl group, 1- (4-n-heptafluoropropylphenyl) -2-imidazolyl group, 2- (4-pentylph Nyl) -4-imidazolyl group, 4- (4-hexylphenyl) -5-imidazolyl group, 1- (2-methoxyphenyl) -2-imidazolyl group, 5- (3-methoxyphenyl) -1-imidazolyl group, 1- (4-methoxyphenyl) -2-imidazolyl group, 2- (3-chloro-2-methoxyphenyl) -4-imidazolyl group, 4- (2-fluoro-3-methoxyphenyl) -5-imidazolyl group, 5- (2-fluoro-4-methoxyphenyl) -1-imidazolyl group, 1- (2,6-dimethoxyphenyl) -2-imidazolyl group, 1- (2,3,4-trifluorophenyl) -2- Imidazolyl group, 1- (2-trifluoromethoxyphenyl) -2-imidazolyl group, 2- (3-trifluoromethoxyphenyl) -4-imidazolyl group, 1- 4-trifluoromethoxyphenyl) -2-imidazolyl group, 1- (3-fluoro-2-trifluoromethoxyphenyl) -2-imidazolyl group, 1- (2-fluoro-3-trifluoromethoxyphenyl) -2- Imidazolyl group, 1- (3-fluoro-4-trifluoromethoxyphenyl) -2-imidazolyl group, 1- (3-chloro-2-trifluoromethoxyphenyl) -2-imidazolyl group, 1- (2-chloro- 3-trifluoromethoxyphenyl) -2-imidazolyl group, 1- (3-chloro-4-trifluoromethoxyphenyl) -2-imidazolyl group, 1- (2-pentafluoroethoxyphenyl) -2-imidazolyl group, 1 -(3-pentafluoroethoxyphenyl) -2-imidazolyl group, 1- (4-pentafluoroethoxy) Phenyl) -2-imidazolyl group, 1- (3-chloro-2-pentafluoroethoxyphenyl) -2-imidazolyl group, 1- (2-chloro-3-pentafluoroethoxyphenyl) -2-imidazolyl group, 1- (3-chloro-4-pentafluoroethoxyphenyl) -2-imidazolyl group, 1- (2-isopropoxyphenyl) -2-imidazolyl group, 1- (3-isopropoxyphenyl) -2-imidazolyl group, 1- (4-isopropoxyphenyl) -2-imidazolyl group, 1- (2-tert-butoxyphenyl) -2-imidazolyl group, 1- (3-tert-butoxyphenyl) -2-imidazolyl group, 1- (4- tert-butoxyphenyl) -2-imidazolyl group, 1- (2-sec-butoxyphenyl) -2-imidazolyl group, -(3-sec-butoxyphenyl) -2-imidazolyl group, 1- (4-sec-butoxyphenyl) -2-imidazolyl group, 1- (2-n-heptafluoropropoxyphenyl) -2-imidazolyl group, 1 -(3-n-heptafluoropropoxyphenyl) -2-imidazolyl group, 1- (4-n-heptafluoropropoxyphenyl) -2-imidazolyl group, 1- (4-n-pentoxyphenyl) -2-imidazolyl Groups, 1- (4-n-hexyloxyphenyl) -2-imidazolyl group, 1,4-diphenyl-2-imidazolyl group, 1,4,5-triphenyl-2-imidazolyl group and the like imidazolyl group [imidazole ring On top of 1 to 3 phenyl groups (on the phenyl ring, halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl And 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted]. Can do.

  A piperazinyl group (on a piperazine ring, a C1-6 alkyl group substituted with two phenyl groups [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1 -6 at least one group selected from the group consisting of alkoxy groups may be substituted], phenyl C1-6 alkyl group [on the phenyl ring, at least one phenoxy group (on the phenyl ring) , A halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group are substituted) A thiazolyl group [at least one phenyl group may be substituted on the thiazole ring], a phenoxy group C1-6 alkyl group [on the phenyl ring, a phenyl group (on the phenyl ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group Selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. At least one of the above groups may be substituted], a phenyl C2-6 alkenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1 And at least one group selected from the group consisting of ˜6 alkoxy groups is substituted.] And imidazolyl [From the group consisting of at least one phenyl group on the imidazole ring (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) For example, it is assumed that at least one group selected from the group consisting of at least one selected group may be substituted) may be substituted] is substituted. 4- [1,1-di (4-chlorophenyl) methyl] -1-piperazinyl group, 4- [1,1-di (4-trifluoromethoxyphenyl) methyl] -1-piperazinyl group, 4- (4 -Chlorocinnamyl) -1-piperazinyl group, 4- (4-trifluoromethoxycinnamyl) -1-piperazinyl group, 4- [1- (4-chlorophenyl) -2-imidazolyl ] -1-piperazinyl group, 4- [1,1-di (2,4-dibromophenyl) methyl] -1-piperazinyl group, 4- [1,1-di (4-trifluoromethylphenyl) methyl]- 1-piperazinyl group, 4- (2,4-dichlorocinnamyl) -1-piperazinyl group, 4- (4-trifluoromethylnamyl) -1-piperazinyl group, 4- {1- [2,4-di (Trifluoromethoxy) phenyl] -2-imidazolyl} -1-piperazinyl group, 4- [1,1-di (2,4,6-trifluorophenyl) methyl] -1-piperazinyl group, 4- {1, 1-di [2,4-di (trifluoromethoxy) phenyl] methyl} -1-piperazinyl group, 4- [2,4,6-tri (trifluoromethyl) cinnamyl] -1-piperazinyl group, 4- [ 2,4-di (tri Fluoromethoxy) cinnamyl] -1-piperazinyl group, 4- [1- (4-trifluoromethylphenyl) -2-imidazolyl] -1-piperazinyl group, 4- (2,4,6-trifluorocinnamyl) -1- Piperazinyl group, 4- [1- (2,4-dibromophenyl) -2-imidazolyl] -1-piperazinyl group, 4- [1,1-di (4-chlorophenyl) methyl] -3- (4-chlorocinna Mil) -1-piperazinyl group, 4- (4-trifluoromethoxycinnamyl) -2- [1- (4-chlorophenyl) -2-imidazolyl] -1-piperazinyl group, 4- (4-trifluoromethoxycinna) Mil) -2- [1- (4-chlorophenyl) -2-imidazolyl] -6- (1-imidazolyl) -1-piperazinyl, 4- [4- (4-trifluoro) Romethoxyphenoxy) benzyl]-(1-, 2- or 3-) piperazinyl group, 4- [4-phenyl- (2- or 5-) thiazolyl]-(1-, 2- or 3-) piperazinyl group, 4- [2- (4-trifluoromethoxyphenoxy) ethyl]-(1-, 2- or 3-) piperazinyl group, 4- [2- (4-phenylphenoxy) ethyl]-(1-, 2- or 3-) Piperazinyl group, 4- [2- (4-chlorophenoxy) ethyl]-(1-, 2- or 3-) piperazinyl group, 4- [2- (3,4-dichlororphenoxy) ethyl]- (1-, 2- or 3-) piperazinyl group, 4- [2- (4-trifluoromethylphenoxy) ethyl]-(1-, 2- or 3-) piperazinyl group, 4- [2- (4- Trifluoromethoxyphenoxy) ethyl]-( A piperazinyl group such as 1-, 2- or 3-) piperazinyl group (on the piperazine ring a C1-6 alkyl group substituted with two phenyl groups [on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted 1 to 5, preferably 1 to 3, groups selected from the group consisting of C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups], phenyl C1-6 alkyls Group [1-3 phenoxy groups on the phenyl ring (consisting of halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring) 1 to 5, preferably 1 to 3 groups selected from the group are substituted), thiazolyl group [on the thiazole ring, 1 Two phenyl groups may be substituted], a phenoxy C1-6 alkyl group [on the phenyl ring, a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups), halogen atoms, halogen-substituted or unsubstituted C1 1 to 5, preferably 1 to 3 groups selected from the group consisting of -6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups], phenyl C2-6 alkenyl groups [1-5 groups selected from a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group, Or 1 to 2 phenyl groups substituted with 1 to 2 and an alkenyl group having 2 to 6 carbon atoms and 1 to 3 double bonds] and an imidazolyl group [on the imidazole ring, 1 ~ 3 phenyl groups (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is 1 to It is assumed that 1 to 3 groups selected from the group consisting of 5 may be substituted, and preferably 1 to 3 may be substituted. ).

  Anilino C1-6 alkyl group [on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; As the species may be substituted], for example, a C1-6 alkyl group may be substituted at the N-position of the anilino group, an unsubstituted anilino group, or a halogen-substituted or unsubstituted C1 as defined above. A group selected from the group consisting of -6 alkyl groups, halogen-substituted or unsubstituted C1-6 alkoxy groups and halogens, preferably 1 to 5, preferably 1 to 3 substituted anilino groups and C1-6 alkyl groups For example, an anilinomethyl group, N-methyl-N-anilinomethyl group, N-ethyl-N-anilinomethyl group, Nn-propyl-N-a Linomethyl group, Nn-butyl-N-anilinomethyl group, Nn-pentyl-N-anilinomethyl group, Nn-hexyl-N-anilinomethyl group, 2-anilinoethyl group, 3-anilinopropyl group, 4- Anilinobutyl group, 5-anilinopentyl group, 6-anilinohexyl group, 4-fluoroanilinomethyl group, 2-fluoro-4-bromoanilinomethyl group, 4-chloro-3-fluoroanilinomethyl group, 2 , 3,4-trichloroanilinomethyl group, 3,4,5-trichloroanilinomethyl group, 2,4,6-trichloroanilinomethyl group, N-methyl-N-2,4,6-trichloroanilino Methyl group, 4-isopropylanilinomethyl group, 4-n-butylanilinomethyl group, 4-methylanilinomethyl group, 2-methylanilinomethyl group, 3- Tyranilinomethyl group, 2,4-dimethylanilinomethyl group, 2,3-dimethylanilinomethyl group, 2,6-dimethylanilinomethyl group, 3,5-dimethylanilinomethyl group, 2,5- Dimethylanilinomethyl group, N-methyl-N-2,5-dimethylanilinomethyl group, 2,4,6-trimethylanilinomethyl group, 3,5-ditrifluoromethylanilinomethyl group, 2,3, 4,5,6-pentafluoroanilinomethyl group, 4-isopropoxyanilinomethyl group, 4-n-butoxyanilinomethyl group, 4-methoxyanilinomethyl group, 2-methoxyanilinomethyl group, 3- Methoxyanilinomethyl group, N-methyl-N-3-methoxyanilinomethyl group, 2,4-dimethoxyanilinomethyl group, 2,3-dimethoxyanilinomethyl group, 2,6- Dimethoxyanilinomethyl group, 3,5-dimethoxyanilinomethyl group, 2,5-dimethoxyanilinomethyl group, 2,4,6-trimethoxyanilinomethyl group, 3,5-ditrifluoromethoxyanilinomethyl group 2-isopropoxyanilinomethyl group, 3-chloro-4-methoxyanilinomethyl group, 2-chloro-4-trifluoromethoxyanilinomethyl group, 3-methyl-4-fluoroanilinomethyl group, 4- Bromo-3-trifluoromethylanilinomethyl group, 2- (4-fluoroanilino) ethyl group, 3- (4-fluoroanilino) propyl group, 4- (4-fluoroanilino) butyl group, 5- (4-fluoroanilino) pentyl group, 6- (4-fluoroanilino) hexyl group, 4-chloroanilinomethyl group, 2- (4-chloroanilino) Til group, 3- (4-chloroanilino) propyl group, 4- (4-chloroanilino) butyl group, 5- (4-chloroanilino) pentyl group, 6- (4-chloroanilino) hexyl group, 4-methylanilinomethyl group 2- (4-methylanilino) ethyl group, 3- (4-methylanilino) propyl group, 4- (4-methylanilino) butyl group, 5- (4-methylanilino) pentyl group, 6- (4-methylanilino) hexyl group 4-trifluoromethylanilinomethyl group, 2- (4-trifluoromethylanilino) ethyl group, 3- (4-trifluoromethylanilino) propyl group, 4- (4-trifluoromethylanilino) Butyl group, N-methyl-N- [4- (4-trifluoromethylanilino)] butyl group, 5- (4-trifluoromethylanilino) Nyl group, 6- (4-trifluoromethylanilino) hexyl group, 4-trifluoromethoxyanilinomethyl group, N-methyl-N-4-trifluoromethoxyanilinomethyl group, 2- (4-trifluoro Methoxyanilino) ethyl group, 3- (4-trifluoromethoxyanilino) propyl group, 4- (4-trifluoromethoxyanilino) butyl group, 5- (4-trifluoromethoxyanilino) pentyl group, 6 -(4-trifluoromethoxyanilino) hexyl group, 4-methoxyanilinomethyl group, 2- (4-methoxyanilino) ethyl group, 3- (4-methoxyanilino) propyl group, 4- (4- Examples include methoxyanilino) butyl group, 5- (4-methoxyanilino) pentyl group, 6- (4-methoxyanilino) hexyl group and the like.

  Thiazolyl C1-6 alkoxy group (on the thiazole ring, (p-1) phenoxy C1-6 alkyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted At least one group selected from the group consisting of substituted C1-6 alkoxy groups may be substituted], (p-2) anilino C1-6 alkyl group [on the phenyl ring, a halogen atom, halogen At least one selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted], (p-3) phenyl C1 A group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring At least one may be substituted], (p-4) piperazinyl C1-6 alkyl group [on the piperazine ring at least one phenyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted At least one group selected from the group consisting of a substituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] and (p -5) piperidyl C1-6 alkyl group [on the piperidine ring at least one phenoxy group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted), and at least one group selected from the group consisting of May be (2-thiazolyl) methoxy group, 2- (4-thiazolyl) ethoxy group, 3- (5-thiazolyl) propoxy group, 4- (2-thiazolyl) butoxy group, -(4-thiazolyl) pentyloxy group, 6- (5-thiazolyl) hexyloxy group, {4- [4- (4-chlorophenoxy) -1-piperidylmethyl] -2-thiazolyl} methoxy group, {4- [4- (4-trifluoromethylphenoxy) -1-piperidylmethyl] -2-thiazolyl} methoxy group, 2-methyl-3- (2-thiazolyl) propoxy group, 1,1-dimethyl-2- (2- Thiazolyl) ethoxy group, {4- [4- (4-trifluoromethoxyphenoxy) -1-piperidylmethyl] -2-thiazolyl} methoxy group, [4- {4- [2,4 Di (trifluoromethoxy) phenoxy] -1-piperidylmethyl} -2-thiazolyl] methoxy group, [4- {4- [2,4,6-tri (trifluoromethyl) phenoxy] -1-piperidylmethyl}- 2-thiazolyl] methoxy group, {4- [4- (2,4-dibromophenoxy) -1-piperidylmethyl] -2-thiazolyl} methoxy group, {4- [4- (2,4,6-trifluoro) Phenoxy) -1-piperidylmethyl] -2-thiazolyl} methoxy group, {4- [4- (4-trifluoromethylphenyl) -1-piperazinylmethyl] -2-thiazolyl} methoxy group, {4- [ 4- (4-trifluoromethoxyphenyl) -1-piperazinylmethyl] -2-thiazolyl} methoxy group, {4- [4- (4-chlorophenyl) -1-piperazini Rumethyl] -2-thiazolyl} methoxy group, [4- {4- [2,4-di (trifluoromethyl) phenyl] -1-piperazinylmethyl} -2-thiazolyl] methoxy group, [4- {4 -[2,4,6-tri (trifluoromethoxy) phenyl] -1-piperazinylmethyl} -2-thiazolyl] methoxy group, {4- [4- (2,4-dibromophenyl) -1-pipe Razinylmethyl] -2-thiazolyl} methoxy group, {4- [4- (2,4,6-trifluorophenyl) -1-piperazinylmethyl] -2-thiazolyl} methoxy group, 4- (4- Trifluoromethylphenoxymethyl) -2-thiazolyl group, [4- (4-trifluoromethoxyphenoxymethoxy) -2-thiazolyl] methoxy group, [4- (4-chlorophenoxymethyl) -2-thia Ril] methoxy group, {4- [2,4-di (trifluoromethoxy) phenoxymethyl] -2-thiazolyl} methoxy group, {4- [2,4,6-tri (trifluoromethyl) phenoxymethyl]- 2-thiazolyl} methoxy group, [4- (2,4-dibromophenoxymethyl) -2-thiazolyl] methoxy group, [4- (2,4,6-trifluorophenoxymethyl) -2-thiazolyl] methoxy group, [4- (4-trifluoromethylanilinomethyl) -2-thiazolyl] methoxy group, [4- (4-trifluoromethoxyanilinomethoxy) -2-thiazolyl] methoxy group, [4- (4-chloroanis Linomethyl) -2-thiazolyl] methoxy group, {4- [2,4-di (trifluoromethoxy) anilinomethyl] -2-thiazolyl} methoxy group, { -[2,4,6-tri (trifluoromethyl) anilinomethyl] -2-thiazolyl} methoxy group, [4- (2,4-dibromoanilinomethyl) -2-thiazolyl] methoxy group, [4- (2 , 4,6-trifluoroanilinomethyl) -2-thiazolyl] methoxy group, {4- [3- (4-trifluoromethoxyphenyl) propyl] -2-thiazolyl} methoxy group, {4- [3- ( 4-trifluoromethylphenyl) propyl] -2-thiazolyl} methoxy group, {4- [3- (4-chlorophenyl) propyl] -2-thiazolyl} methoxy group, [4- (2,4-diiodobenzyl) -2-thiazolyl] methoxy group, [4- (2,4,6-tribromobenzyl) -2-thiazolyl] methoxy group, {4- [2,4-di (trifluoromethoxy) benzyl Ru] -2-thiazolyl} methoxy group, {4- [2,4,6-tri (trifluoromethyl) benzyl] -2-thiazolyl} methoxy group, (4,5-dibenzyl-2-thiazolyl) methoxy group, Thiazolyl C1-6 alkoxy groups such as (2-phenoxymethyl-4-benzyl-5-thiazolyl) methoxy group and (2,5-dianilinomethyl-4-thiazolyl) methoxy group (on the thiazole ring, phenoxy C1-6 alkyl) Group [on the phenyl ring, 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group, preferably 1 to 3 optionally substituted], anilino C1-6 alkyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 1 to 5, preferably 1 to 3 substituents selected from the group consisting of an alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group], a phenyl C1-6 alkyl group [phenyl On the ring, there are 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. May be substituted], piperazinyl C1-6 alkyl group [on the piperazine ring 1-3 phenyl groups (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group And 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted] and piperidyl 1 to 6 alkyl groups [on the piperidine ring, 1 to 3 phenoxy groups (on the phenyl ring, halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 1 to 5, preferably 1 to 3 groups selected from the group consisting of alkoxy groups may be substituted, and 1 to 3 groups selected from the group consisting of May be substituted).

  8-azabicyclo [3.2.1] octyl group (on the 8-azabicyclo [3.2.1] octane ring, at least one phenoxy group [on the phenyl ring, halogen atom, halogen substituted or unsubstituted The C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] may be substituted, for example. , 8-azabicyclo [3.2.1] octyl group, 3- (4-trifluoromethoxyphenoxy) -8-azabicyclo [3.2.1] octyl group, 3- (4-trifluoromethylphenoxy) -8 -Azabicyclo [3.2.1] octyl group, 3- (4-chlorophenoxy) -8-azabicyclo [3.2.1] octyl group, 3- (2,4-dichlorophenoxy) -8 Azabicyclo [3.2.1] octyl group, 3- (2,4,6-trichlorophenoxy) -8-azabicyclo [3.2.1] octyl group, 3- (2-bromophenoxy) -8-azabicyclo [ 3.2.1] Octyl group, 3- (3-fluorophenoxy) -8-azabicyclo [3.2.1] octyl group, 3- [2,4-di (trifluoromethoxy) phenoxy] -8-azabicyclo [3.2.1] octyl group, 3- [2,4,6-tri (trifluoromethoxy) phenoxy] -8-azabicyclo [3.2.1] octyl group, 3- [2,4-di ( Trifluoromethyl) phenoxy] -8-azabicyclo [3.2.1] octyl group, 3- [2,4,6-tri (trifluoromethyl) phenoxy] -8-azabicyclo [3.2.1] octyl group , 3, -Diphenoxy-8-azabicyclo [3.2.1] octyl group, 3,7,6-triphenoxy-8-azabicyclo [3.2.1] octyl group, 3- (4-methoxyphenoxy) -8-azabicyclo [3.2.1] octyl group, 3- (4-methylphenoxy) -8-azabicyclo [3.2.1] octyl group, 3- (2,4-dimethoxyphenoxy) -8-azabicyclo [3.2 .1] Octyl group, 3- (2,4,6-trimethoxyphenoxy) -8-azabicyclo [3.2.1] octyl group, 3- (2,4-dimethylphenoxy) -8-azabicyclo [3. 2.1] Octyl group, 8-azabicyclo [3.2.1] octyl group (8-azabicyclo) such as 3- (2,4,6-trimethylphenoxy) -8-azabicyclo [3.2.1] octyl group [3 2.1] 1 to 3 phenoxy groups on the octane ring [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy 1 to 5, preferably 1 to 3 groups selected from the group consisting of groups may be substituted).

  As the benzofuryl C1-6 alkyl group (on the benzofuran ring, at least one halogen-substituted or unsubstituted C1-6 alkyl group may be substituted), for example, [(2-, 3-, 4 -, 5-, 6- or 7-) benzofuryl] methyl group, 1-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] ethyl group, 2-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] ethyl group, 3-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] propyl group, 2- [ (2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] propyl group, 4-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] butyl group , 5-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] pentyl group, 4-[(2-, 3-, 4 , 5-, 6- or 7-) benzofuryl] pentyl group, 6-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] hexyl group, 2-methyl-3-[( 2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] propyl group, 1,1-dimethyl-2-[(2-, 3-, 4-, 5-, 6- or 7- ) Benzofuryl] ethyl group, 2-trifluoromethyl- (3-, 4-, 5-, 6- or 7-) benzofurylmethyl group, 5-trifluoromethyl- (2-, 3-, 4-, 6 -Or 7-) benzofurylmethyl group, 4-methyl- (2-, 3-, 5-, 6- or 7-) benzofurylmethyl group, 2,4-dimethyl- (3-, 5-, 6- Or 7-) benzofurylmethyl group, 2,4,6-trimethyl- (3-, 5- or 7-) benzofurylmethyl group, 4-tri Fluoromethyl- (2-, 3-, 5-, 6- or 7-) benzofurylmethyl group, 6-trifluoromethyl- (2-, 3-, 4-, 5- or 7-) benzofurylmethyl group, etc. A benzofuryl C1-6 alkyl group in which the alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms (on the benzofuran ring, 1 to 3 halogen-substituted or unsubstituted C1-6 alkyl groups Can be substituted).

  Piperidylcarbonyl C1-6 alkyl group [on the piperidine ring at least one phenoxy group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 The group may be substituted with at least one group selected from the group consisting of 6 alkoxy groups, which may be substituted, for example, (4-phenoxy-1-piperidylcarbonyl) methyl group, 2 -(3-phenoxy-2-piperidylcarbonyl) ethyl group, 3- (2-phenoxy-3-piperidylcarbonyl) propyl group, 4- (1-phenoxy-4-piperidylcarbonyl) butyl group, 5- (4-phenoxy) -1-piperidylcarbonyl) pentyl group, 6- (1-phenoxy-2-piperidylcarbonyl) hexyl group, 1 (4-trifluoromethoxyphenoxy) -4-piperidylcarbonylmethyl group, 4- (4-trifluoromethoxyphenoxy) -1-piperidylcarbonylmethyl group, 4- (4-trifluoromethylphenoxy) -1-piperidylcarbonylmethyl Group, 4- (3-methoxyphenoxy) -1-piperidylcarbonylmethyl group, 1- (2-methylphenoxy) -4-piperidylcarbonylmethyl group, 4- (4-chlorophenoxy) -1-piperidylcarbonylmethyl group, 4- [3,4-di (trifluoromethoxy) phenoxy] -1-piperidylcarbonylmethyl group, 4- [2,4,6-tri (trifluoromethyl) phenoxy] -1-piperidylcarbonylmethyl group, 4- (3,4-Dimethylphenoxy) -1-piperidylcarbonyl 4- (2,4,6-trimethoxyphenoxy) -4-piperidylcarbonylmethyl group, 2- (3,4-dichlorophenoxy) -1-piperidylcarbonylmethyl group, 3- (2,4,6) An alkyl moiety such as (tribromophenoxy) -1-piperidylcarbonylmethyl group, (1,2,6-triphenoxy-4-piperidylcarbonyl) methyl group, (2,4-diphenoxy-1-piperidylcarbonyl) methyl group; Piperidylcarbonyl C1-6 alkyl group which is a linear or branched alkyl group having 1 to 6 carbon atoms (on the piperidine ring, 1 to 3 phenoxy groups (on the phenyl ring, halogen atom, halogen substitution) Or 1 to 5 groups selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. Or 1 to 3 substituents may be substituted). ).

  Examples of the amino-substituted C1-6 alkyl group that may have a C1-6 alkyl group as a substituent include an aminomethyl group, a 2-aminoethyl group, a 1-aminoethyl group, a 3-aminopropyl group, and a 4-amino group. Butyl group, 5-aminopentyl group, 6-aminohexyl group, 2-methyl-3-aminopropyl group, 1,1-dimethyl-2-aminoethyl group, ethylaminomethyl group, 1- (propylamino) ethyl group 2- (methylamino) ethyl group, 3- (isopropylamino) propyl group, 4- (n-butylamino) butyl group, 5- (n-pentylamino) pentyl group, 6- (n-hexylamino) hexyl Substituents such as a group, dimethylaminomethyl group, (N-ethyl-N-propylamino) methyl group, 2- (N-methyl-N-hexylamino) ethyl group, Which may have one or two a C1~6 alkyl group Te amino -C1~6 alkyl group can be exemplified.

  Examples of the C1-6 alkylene group include methylene, ethylene, trimethylene, 2-methyltrimethylene, 2,2-dimethyltrimethylene, 1-methyltrimethylene, methylmethylene, ethylmethylene, tetramethylene, pentamethylene, hexamethylene. Groups and the like.

  Pyridyl C1-6 alkyl group [on the pyridine ring, at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 The group may be substituted with at least one group selected from the group consisting of alkoxy groups]. For example, in addition to the pyridyl C1-6 alkyl group, 2- (4 -Trifluoromethoxyphenyl)-(3-, 4-, 5- or 6-) pyridylmethyl group, 2- (4-trifluoromethylphenyl)-(3-, 4-, 5- or 6-) pyridylmethyl Group, 2- (4-methoxyphenyl)-(3-, 4-, 5- or 6-) pyridylmethyl group, 2- (4-methylphenyl)-(3-, 4-, 5- or 6-) Pyridylmethyl group, 2- 3-chloro-4-fluorophenyl)-(3-, 4-, 5- or 6-) pyridylmethyl group, 2- (2,4-dimethoxyphenyl)-(3-, 4-, 5- or 6- ) Pyridylmethyl group, 2- (3,4,5-trimethoxyphenyl)-(3-, 4-, 5- or 6-) pyridylmethyl group, 2- (2,4-dimethylphenyl)-(3- 4-, 5- or 6-) pyridylmethyl group, 2- (2,4,6-trimethylphenyl)-(3-, 4-, 5- or 6-) pyridylmethyl group, 2- (2,4 , 6-trichlorophenyl)-(3-, 4-, 5- or 6-) pyridylmethyl group, 2- (3-chloro-4-trifluoromethoxyphenyl)-(3-, 4-, 5- or 6 -) Pyridylmethyl group, 2,4,6-triphenyl- (3- or 5-) pyridylmethyl group, , 5-diphenyl- (3-, 4- or 6-) pyridyl C1-6 alkyl group wherein the alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms [on the pyridine ring 1 to 3 phenyl groups (on the phenyl ring, selected from the group consisting of halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups) 1 to 5, preferably 1 to 3 groups may be substituted)].

  Phenyl C1-6 alkoxycarbonyl group [on the phenyl ring, at least a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; Is optionally selected from the group consisting of a halogen atom as defined above, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. A group composed of a phenyl C1-6 alkoxy group optionally substituted with 1 to 5, preferably 1 to 3 groups, and a carbonyl group, such as a benzyloxycarbonyl group or a 2-phenylethoxycarbonyl group 3-phenylpropoxycarbonyl group, 2-phenylpropoxycarbonyl group, 4-phenylbutoxycar Nyl group, 5-phenylpentoxycarbonyl group, 4-phenylpentoxycarbonyl group, 6-phenylhexyloxycarbonyl group, 2-fluorobenzyloxycarbonyl group, 3-fluorobenzyloxycarbonyl group, 4-fluorobenzyloxycarbonyl group 2- (2-fluorophenyl) ethoxycarbonyl group, 2- (3-fluorophenyl) ethoxycarbonyl group, 2- (4-fluorophenyl) ethoxycarbonyl group, 2-chlorobenzyloxycarbonyl group, 3-chlorobenzyloxy Carbonyl group, 4-chlorobenzyloxycarbonyl group, 2-fluoro-4-bromobenzyloxycarbonyl group, 4-chloro-3-fluorobenzyloxycarbonyl group, 2,3,4-trichlorobenzyloxycarbonyl group, 3,4 5-trifluorobenzyloxycarbonyl group, 2,3,4,5,6-pentafluorobenzyloxycarbonyl group, 2,4,6-trichlorobenzyloxycarbonyl group, 4-isopropylbenzyloxycarbonyl group, 4-n- Butylbenzyloxycarbonyl group, 4-methylbenzyloxycarbonyl group, 2-methylbenzyloxycarbonyl group, 3-methylbenzyloxycarbonyl group, 2,4-dimethylbenzyloxycarbonyl group, 2,3-dimethylbenzyloxycarbonyl group, 2,6-dimethylbenzyloxycarbonyl group, 3,5-dimethylbenzyloxycarbonyl group, 2,5-dimethylbenzyloxycarbonyl group, 2,4,6-trimethylbenzyloxycarbonyl group, 3,5-ditrifluoromethylbenzyl Oki Sicarbonyl group, 4-isopropoxybenzyloxycarbonyl group, 4-n-butoxybenzyloxycarbonyl group, 4-methoxybenzyloxycarbonyl group, 2-methoxybenzyloxycarbonyl group, 3-methoxybenzyloxycarbonyl group, 2,4 -Dimethoxybenzyloxycarbonyl group, 2,3-dimethoxybenzyloxycarbonyl group, 2,6-dimethoxybenzyloxycarbonyl group, 3,5-dimethoxybenzyloxycarbonyl group, 2,5-dimethoxybenzyloxycarbonyl group, 2,4 , 6-trimethoxybenzyloxycarbonyl group, 3,5-ditrifluoromethoxybenzyloxycarbonyl group, 2-isopropoxybenzyloxycarbonyl group, 3-chloro-4-methoxybenzyloxycarbonyl group, 2 Chloro-4-trifluoromethoxybenzyloxycarbonyl group, 3-methyl-4-fluorobenzyloxycarbonyl group, 4-bromo-3-trifluoromethylbenzyloxycarbonyl group, 2- (2-chlorophenyl) ethoxycarbonyl group, 2 -(3-chlorophenyl) ethoxycarbonyl group, 2- (4-chlorophenyl) ethoxycarbonyl group, 2-trifluoromethylbenzyloxycarbonyl group, 3-trifluoromethylbenzyloxycarbonyl group, 4-trifluoromethylbenzyloxycarbonyl group 2-trifluoromethoxybenzyloxycarbonyl group, 3-trifluoromethoxybenzyloxycarbonyl group, 4-trifluoromethoxybenzyloxycarbonyl group, 2- (2-trifluoromethylphenyl) ethoxy Carbonyl group, 2- (3-trifluoromethylphenyl) ethoxycarbonyl group, 2- (4-trifluoromethylphenyl) ethoxycarbonyl group, 2- (2-trifluoromethoxyphenyl) ethoxycarbonyl group, 2- (3- Trifluoromethoxyphenyl) ethoxycarbonyl group, 2- (4-trifluoromethoxyphenyl) ethoxycarbonyl group, 3- (2-trifluoromethylphenyl) propoxycarbonyl group, 3- (3-trifluoromethylphenyl) propoxycarbonyl group 3- (4-trifluoromethylphenyl) propoxycarbonyl group, 3- (2-trifluoromethylphenyl) propoxycarbonyl group, 3- (3-trifluoromethoxyphenyl) propoxycarbonyl group, 3- (4-trifluoro Methoxypheni L) propoxycarbonyl group, 4- (3-trifluoromethylphenyl) butoxycarbonyl group, 5- (4-trifluoromethylphenyl) pentoxycarbonyl group, 4- (4-trifluoromethylphenyl) pentoxycarbonyl group, 4- (4-trifluoromethoxyphenyl) pentoxycarbonyl group, 6- (3-trifluoromethylphenyl) hexyloxycarbonyl group, 6- (4-trifluoromethylphenyl) hexyloxycarbonyl group, 6- (4- (Trifluoromethoxyphenyl) hexyloxycarbonyl group and the like.

  Phenyl C2-6 alkenylcarbonyl group [on the phenyl ring, at least a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; As one kind may be substituted], for example, 1 to 5 groups selected from unsubstituted or halogen atoms, halogen C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups, Preferably, it is a group composed of 1 to 3 substituted phenyl groups and an alkenylcarbonyl group having 2 to 6 carbon atoms and 1 to 3 double bonds. The phenyl C2-6 alkenylcarbonyl group includes both trans form and cis form. Examples of such phenyl C2-6 alkenylcarbonyl groups include 2-phenylvinylcarbonyl group, 3-phenyl-2-propenylcarbonyl group (common name: cinnamoyl group), 4-phenyl-2-butenylcarbonyl group, 4-phenyl-3-butenylcarbonyl group, 4-phenyl-1,3-butadienylcarbonyl group, 5-phenyl-1,3,5-hexatrienylcarbonyl group, 3- (2-fluorophenyl)- 2-propenylcarbonyl group, 3- (3-fluorophenyl) -2-propenylcarbonyl group, 3- (4-fluorophenyl) -2-propenylcarbonyl group, 3- (2,3-difluorophenyl) -2-propenyl Carbonyl group, 3- (2,3,4,5,6-pentafluorophenyl) -2-propenylcarbonyl group 3- (2,4-difluorophenyl) -2-propenylcarbonyl group, 3- (3,4-difluorophenyl) -2-propenylcarbonyl group, 3- (3,5-difluorophenyl) -2-propenylcarbonyl group , 3- (2-chlorophenyl) -2-propenylcarbonyl group, 3- (3-chlorophenyl) -2-propenylcarbonyl group, 3- (4-chlorophenyl) -2-propenylcarbonyl group, 3- (2,3- Dichlorophenyl) -2-propenylcarbonyl group, 3- (2,4-dichlorophenyl) -2-propenylcarbonyl group, 3- (3,4-dichlorophenyl) -2-propenylcarbonyl group, 3- (3,5-dichlorophenyl) 2-propenylcarbonyl group, 3- (2-bromophenyl) -2-propenylcarbonyl group, -(3-bromophenyl) -2-propenylcarbonyl group, 3- (4-bromophenyl) -2-propenylcarbonyl group, 3- (2-methylphenyl) -2-propenylcarbonyl group, 3- (3-methyl Phenyl) -2-propenylcarbonyl group, 3- (4-methylphenyl) -2-propenylcarbonyl group, 3- (4-trifluoromethylphenyl) -2-propenylcarbonyl group, 3- (2-fluoro-4-) Bromophenyl) -2-propenylcarbonyl group, 3- (4-chloro-3-fluorophenyl) -2-propenylcarbonyl group, 3- (2,3,4-trichlorophenyl) -2-propenylcarbonyl group, 3- (2,4,6-trichlorophenyl) -2-propenylcarbonyl group, 3- (4-isopropylphenyl) -2-propene Nylcarbonyl group, 3- (4-n-butylphenyl) -2-propenylcarbonyl group, 3- (2,4-dimethylphenyl) -2-propenylcarbonyl group, 3- (2,3-dimethylphenyl) -2 -Propenylcarbonyl group, 3- (2,6-dimethylphenyl) -2-propenylcarbonyl group, 3- (3,5-dimethylphenyl) -2-propenylcarbonyl group, 3- (2,5-dimethylphenyl)- 2-propenylcarbonyl group, 3- (2,4,6-trimethylphenyl) -2-propenylcarbonyl group, 3- (3,5-ditrifluoromethylphenyl) -2-propenylcarbonyl group, 3- (4-n -Butoxyphenyl) -2-propenylcarbonyl group, 3- (2,4-dimethoxyphenyl) -2-propenylcarbonyl group, 3- (2, -Dimethoxyphenyl) -2-propenylcarbonyl group, 3- (2,6-dimethoxyphenyl) -2-propenylcarbonyl group, 3- (3,5-dimethoxyphenyl) -2-propenylcarbonyl group, 3- (2, 5-dimethoxyphenyl) -2-propenylcarbonyl group, 3- (3,5-ditrifluoromethoxyphenyl) -2-propenylcarbonyl group, 3- (3-chloro-4-methoxyphenyl) -2-propenylcarbonyl group, 3- (2-chloro-4-trifluoromethoxyphenyl) -2-propenylcarbonyl group, 3- (3-methyl-4-fluorophenyl) -2-propenylcarbonyl group, 3- (4-bromo-3-triphenyl) Fluoromethylphenyl) -2-propenylcarbonyl group, 3- (3-trifluoromethylphenyl) -2 Propenylcarbonyl group, 3- (4-trifluoromethylphenyl) -2-propenylcarbonyl group, 3- (2-trifluoromethoxyphenyl) -2-propenylcarbonyl group, 3- (3-trifluoromethoxyphenyl) -2 -Propenylcarbonyl group, 3- (4-trifluoromethoxyphenyl) -2-propenylcarbonyl group, 3- (2-methoxyphenyl) -2-propenylcarbonyl group, 3- (3-methoxyphenyl) -2-propenylcarbonyl Group, 3- (4-methoxyphenyl) -2-propenylcarbonyl group, 3- (3,4-dimethoxyphenyl) -2-propenylcarbonyl group, 3- (3,5-dimethoxyphenyl) -2-propenylcarbonyl group 4- (4-chlorophenyl) -2-butenylcarbonyl group, 4- (4 -Chlorophenyl) -3-butenylcarbonyl, 5- (4-chlorophenyl) -2-pentenylcarbonyl, 5- (4-chlorophenyl) -4-pentenylcarbonyl, 5- (4-chlorophenyl) -3-pentenyl Group, 6- (4-chlorophenyl) -5-hexenylcarbonyl group, 6- (4-chlorophenyl) -4-hexenyl group, 6- (4-chlorophenyl) -3-hexenylcarbonyl group, 6- (4-chlorophenyl) A -3-hexenylcarbonyl group can be exemplified.

  Examples of the C1-4 alkylenedioxy group include a methylenedioxy group, an ethylenedioxy group, a trimethylenedioxy group, and a tetramethylenedioxy group.

  Examples of the amino-substituted sulfonyl group that may have a C1-6 alkyl group as a substituent include an aminosulfonyl group, a methylaminosulfonyl group, an ethylaminosulfonyl group, a propylaminosulfonyl group, an isopropylaminosulfonyl group, a butylaminosulfonyl group, tert-Butylaminosulfonyl group, pentylaminosulfonyl group, hexylaminosulfonyl group, dimethylaminosulfonyl group, diethylaminosulfonyl group, dipropylaminosulfonyl group, dibutylaminosulfonyl group, dipentylaminosulfonyl group, dihexylaminosulfonyl group, N-methyl -N-ethylaminosulfonyl group, N-ethyl-N-propylaminosulfonyl group, N-methyl-N-butylaminosulfonyl group, N-methyl-N-hexylami It can be exemplified aminosulfonyl group which may have one or two a C1~6 alkyl group as a substituent such as a sulfonyl group.

  Examples of the phenyl C1-6 alkoxy group include benzyloxy group, 2-phenylethoxy group, 1-phenylethoxy group, 3-phenylpropoxy group, 2-phenylpropoxy group, 4-phenylbutoxy group, and 5-phenylpentoxy group. Group, 4-phenylpentoxy group, 6-phenylhexyloxy group, 2-methyl-3-phenylpropoxy group, 1,1-dimethyl-2-phenylethoxy group and the like.

  Examples of the pyrrolidinyl group [at least one oxo group may be substituted on the pyrrolidine ring] include, for example, a pyrrolidinyl group, a 2-oxopyrrolidinyl group, a 2,5-dioxopyrrolidinyl group, and the like. Pyrrolidinyl group (1-2 oxo groups may be substituted on the pyrrolidine ring).

  Examples of the pyrrolidinyl C1-6 alkoxy group include (1-pyrrolidinyl) methoxy group, 2- (1-pyrrolidinyl) ethoxy group, 1- (2-pyrrolidinyl) ethoxy group, 3- (1-pyrrolidinyl) propoxy group, 2 -(3-pyrrolidinyl) propoxy group, 4- (1-pyrrolidinyl) butoxy group, 5- (2-pyrrolidinyl) pentoxy group, 4- (3-pyrrolidinyl) pentoxy group, 6- (1-pyrrolidinyl) hexyloxy group, Examples include 2-methyl-3- (1-pyrrolidinyl) propoxy group and 1,1-dimethyl-2- (1-pyrrolidinyl) ethoxy group.

  As the benzofuryl C1-6 alkyl group (on the benzofuran ring, at least one halogen atom may be substituted as a substituent), for example, a 2-benzofurylmethyl group, 1- (2-benzofuryl) ethyl Group, 2- (4-benzofuryl) ethyl group, 3- (5-benzofuryl) propyl group, 4- (6-benzofuryl) butyl group, 5- (7-benzofuryl) pentyl group, 6- (2-benzofuryl) hexyl Group, 4-fluoro-2-benzofurylmethyl group, 5-fluoro-2-benzofurylmethyl group, 6-fluoro-2-benzofurylmethyl group, 7-fluoro-2-benzofurylmethyl group, 4-chloro- 2-benzofurylmethyl group, 5-chloro-2-benzofurylmethyl group, 6-chloro-2-benzofurylmethyl group, 7-chloro-2-benzo Rylmethyl group, 4-bromo-2-benzofurylmethyl group, 5-bromo-2-benzofurylmethyl group, 6-bromo-2-benzofurylmethyl group, 7-bromo-2-benzofurylmethyl group, 4-iodo 2-benzofurylmethyl group, 5-iodo-2-benzofurylmethyl group, 6-iodo-2-benzofurylmethyl group, 7-iodo-2-benzofurylmethyl group, 4-fluoro-3-benzofurylmethyl Group, 5-fluoro-3-benzofurylmethyl group, 6-fluoro-3-benzofurylmethyl group, 7-fluoro-3-benzofurylmethyl group, 4-chloro-3-benzofurylmethyl group, 5-chloro- 3-benzofurylmethyl group, 6-chloro-3-benzofurylmethyl group, 7-chloro-3-benzofurylmethyl group, 4-bromo-3-benzofurylmethyl group 5-bromo-3-benzofurylmethyl group, 6-bromo-3-benzofurylmethyl group, 7-bromo-3-benzofurylmethyl group, 4-iodo-3-benzofurylmethyl group, 5-iodo-3 -Benzofurylmethyl group, 6-iodo-3-benzofurylmethyl group, 7-iodo-3-benzofurylmethyl group, 2- (4-fluoro-2-benzofuryl) ethyl group, 2- (5-fluoro-2) -Benzofuryl) ethyl group, 2- (6-fluoro-2-benzofuryl) ethyl group, 2- (7-fluoro-2-benzofuryl) ethyl group, 2- (4-chloro-2-benzofuryl) ethyl group, 2- (5-chloro-2-benzofuryl) ethyl group, 2- (6-chloro-2-benzofuryl) ethyl group, 2- (7-chloro-2-benzofuryl) ethyl group, 2- (4-fluoro-3) -Benzofuryl) methyl group, 2- (5-fluoro-3-benzofuryl) methyl group, 2- (6-fluoro-3-benzofuryl) ethyl group, 2- (7-fluoro-3-benzofuryl) ethyl group, 2- (4-chloro-3-benzofuryl) ethyl group, 2- (5-chloro-3-benzofuryl) ethyl group, 2- (6-chloro-3-benzofuryl) ethyl group, 2- (7-chloro-3-benzofuryl) ) Ethyl group, 2- (4-fluoro-2-benzofuryl) ethyl group, 6- (5-fluoro-2-benzofuryl) hexyl group, 6- (6-fluoro-2-benzofuryl) hexyl group, 6- (7 -Fluoro-2-benzofuryl) hexyl group, 6- (4-chloro-2-benzofuryl) hexyl group, 6- (5-chloro-2-benzofuryl) hexyl group, 6- (6-chloro- -Benzofuryl) hexyl group, 6- (7-chloro-2-benzofuryl) hexyl group, 6- (4-fluoro-3-benzofuryl) methyl group, 6- (5-fluoro-3-benzofuryl) hexyl group, 6- (6-Fluoro-3-benzofuryl) hexyl group, 6- (7-fluoro-3-benzofuryl) hexyl group, 6- (4-chloro-3-benzofuryl) hexyl group, 6- (5-chloro-3-benzofuryl) ) Hexyl group, 6- (6-chloro-3-benzofuryl) hexyl group, 6- (7-chloro-3-benzofuryl) hexyl group, (2,4-dibromo-3-benzofuryl) methyl group, (4,5 Benzofuryl-substituted C1-6 alkyl group optionally substituted by 1 to 3 halogen atoms on a benzofuran ring such as a, 6-trichloro-3-benzofuryl) methyl group. It can gel.

  A phenoxy C1-6 alkyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group) Is optionally substituted) from the group consisting of an unsubstituted phenoxy group or a halogen-substituted or unsubstituted C1-6 alkyl group as defined above, a halogen-substituted or unsubstituted C1-6 alkoxy group and a halogen. A group composed of a phenoxy group substituted with 1 to 5, preferably 1 to 3 selected groups, and a C1-6 alkyl group, such as a phenoxymethyl group, a 2-phenoxyethyl group, and a 3-phenoxy group. Propyl group, 4-phenoxybutyl group, 5-phenoxypentyl group, 6-phenoxyhexyl group, 4-fluoro-6-methyl Phenoxymethyl group, 2-fluoro-4-bromophenoxymethyl group, 2-fluoro-4-bromophenoxymethyl group, 4-chloro-3-fluorophenoxymethyl group, 2-chlorophenoxymethyl group, 3-chlorophenoxymethyl group 4-chlorophenoxymethyl group, 3,4-dichlorophenoxymethyl group, 2,3,4-trichlorophenoxymethyl group, 3,4,5-trichlorophenoxymethyl group, 2,4,6-trichlorophenoxymethyl group, 2- (2-chlorophenoxy) ethyl group, 2- (3-chlorophenoxy) ethyl group, 2- (4-chlorophenoxy) ethyl group, 2- (3,4-dichlorophenoxy) ethyl group, 2- (4 -Fluorophenoxy) ethyl group, 4-isopropylphenoxymethyl group, 4-n-butylphenoxyme Group, 4-methylphenoxymethyl group, 2-methylphenoxymethyl group, 3-methylphenoxymethyl group, 4-n-propylphenoxymethyl group, 4-isopropylphenoxymethyl group, 2,4-dimethylphenoxymethyl group, 2 , 3-dimethylphenoxymethyl group, 2,6-dimethylphenoxymethyl group, 3,5-dimethylphenoxymethyl group, 2,5-dimethylphenoxymethyl group, 2,4,6-trimethylphenoxymethyl group, 4-hexylphenoxy Methyl group, 2- (3-methylphenoxy) ethyl group, 2- (3,4-dimethylphenoxy) ethyl group, 3,5-ditrifluoromethylphenoxymethyl group, 2,3,4,5,6-pentafluoro Phenoxymethyl group, 4-isopropoxyphenoxymethyl group, 4-n-butoxypheno Xymethyl group, 4-methoxyphenoxymethyl group, 2-methoxyphenoxymethyl group, 3-methoxyphenoxymethyl group, 2- (3-methoxyphenoxy) ethyl group, 2- (4-methoxyphenoxy) ethyl group, 2- (3 , 4-dimethoxyphenoxy) ethyl group, 2,4-dimethoxyphenoxymethyl group, 2,3-dimethoxyphenoxymethyl group, 3,4-dimethoxyphenoxymethyl group, 2,6-dimethoxyphenoxymethyl group, 3,5-dimethoxy Phenoxymethyl group, 2,5-dimethoxyphenoxymethyl group, 2,4,6-trimethoxyphenoxymethyl group, 3,4,5-trimethoxyphenoxymethyl group, 3,5-ditrifluoromethoxyphenoxymethyl group, 2- Isopropoxyphenoxymethyl group, 3-chloro-4-methoxyphenyl Noxymethyl group, 2-chloro-4-methoxyphenoxymethyl group, 2-chloro-4-trifluoromethoxyphenoxymethyl group, 3-methyl-4-fluorophenoxymethyl group, 4-bromo-3-trifluoromethylphenoxymethyl group 2- (4-fluorophenoxy) ethyl group, 3- (4-fluorophenoxy) propyl group, 4- (4-fluorophenoxy) butyl group, 5- (4-fluorophenoxy) pentyl group, 6- (4- Fluorophenoxy) hexyl group, 4-chlorophenoxymethyl group, 3- (4-chlorophenoxy) propyl group, 4- (4-chlorophenoxy) butyl group, 5- (4-chlorophenoxy) pentyl group, 6- (4 -Chlorophenoxy) hexyl group, 4-methylphenoxymethyl group, 2- (4-methylphenoxy) Ethyl group, 2- (2-isopropylphenoxy) ethyl group, 2- (4-isopropylphenoxy) ethyl group, 2- (4-hexylphenoxy) ethyl group, 2- (2-fluoro-5-methylphenoxy) ethyl group 2- (2-chloro-4-methoxyphenoxy) ethyl group, 2- (3-fluoro-4-chlorophenoxy) ethyl group, 2- (3,4,5-trimethylphenoxy) ethyl group, 3- (4 -Methylphenoxy) propyl group, 4- (4-methylphenoxy) butyl group, 5- (4-methylphenoxy) pentyl group, 6- (4-methylphenoxy) hexyl group, 4-trifluoromethylphenoxymethyl group, 2 -Trifluoromethylphenoxymethyl group, 3-trifluoromethylphenoxymethyl group, 2- (4-trifluoromethylphenoxy group) ) Ethyl group, 2- (2-trifluoromethylphenoxy) ethyl group, 2- (3-trifluoromethylphenoxy) ethyl group, 3- (4-trifluoromethylphenoxy) propyl group, 4- (4-trifluoro) Methylphenoxy) butyl group, 5- (4-trifluoromethylphenoxy) pentyl group, 6- (4-trifluoromethylphenoxy) hexyl group, 4-trifluoromethoxyphenoxymethyl group, 2- (4-trifluoromethoxyphenoxy) ) Ethyl group, 2- (3-trifluoromethoxyphenoxy) ethyl group, 2- (2-trifluoromethoxyphenoxy) ethyl group, 3- (4-trifluoromethoxyphenoxy) propyl group, 4- (4-trifluoro) Methoxyphenoxy) butyl group, 5- (4-trifluoromethoxyphenoxy) Nyl group, 6- (4-trifluoromethoxyphenoxy) hexyl group, 4-methoxyphenoxymethyl group, 2-isopropoxyphenoxymethyl group, 2- (4-methoxyphenoxy) ethyl group, 3- (4-methoxyphenoxy) A propyl group, 4- (4-methoxyphenoxy) butyl group, 5- (4-methoxyphenoxy) pentyl group, 6- (4-methoxyphenoxy) hexyl group and the like can be mentioned.

  A thiazolyl C1-6 alkyl group (on the thiazole ring, at least one phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy; The group may be substituted with at least one group selected from the group consisting of groups]. For example, 2-thiazolylmethyl group, 4-thiazolylmethyl group, 5-thiazolylmethyl group, 5 -Phenyl-4-thiazolylmethyl group, 4-phenyl-5-thiazolylmethyl group, 2-phenyl-4-thiazolylmethyl group, 2-phenyl-5-thiazolylmethyl group, 2,5-diphenyl-4-thiazolylmethyl group, 2,4- Diphenyl-5-thiazolylmethyl group, 5- (2-fluorophenyl) -4-thiazolyl group 4- (2-fluorophenyl) -5-thiazolylmethyl group, 2- (2-chlorophenyl) -4-thiazolylmethyl group, 2- (2-bromophenyl) -5-thiazolylmethyl group, 2- (2,3 , 4,5,6-pentafluorophenyl) -4-thiazolylmethyl group, 2- (2-bromophenyl) -5-thiazolylmethyl group, 5- (3-iodophenyl) -4-thiazolylmethyl group, 4- (3- Fluorophenyl) -5-thiazolylmethyl group, 2- (2,3-difluorophenyl) -4-thiazolylmethyl group, 2- (3-bromophenyl) -5-thiazolylmethyl group, 2- (3,4,5-trifluoro Phenyl) -4-thiazolylmethyl group, 2- (3-fluorophenyl) -5-thiazolylmethyl group, 5- (2,4,6-trichloropheny ) -4-thiazolylmethyl group, 4- (2,3,4,5,6-pentafluorophenyl) -5-thiazolylmethyl group, 2- (4-fluorophenyl) -4-thiazolylmethyl group, 4- (2-fluoro) Phenyl) -5-thiazolylmethyl group, 2- (4-fluorophenyl) -5-thiazolylmethyl group, 5- (2-chlorophenyl) -4-thiazolylmethyl group, 4- (2-chlorophenyl) -5-thiazolylmethyl group, 2- (2-chlorophenyl) -5-thiazolylmethyl group, 5- (3-methylphenyl) -4-thiazolylmethyl group, 4- (3-ethylphenyl) -5-thiazolylmethyl group, 2- (3-propylphenyl) -4- Thiazolylmethyl group, 2- (2-n-butylphenyl) -5-thiazolylmethyl group, 2- (3-n-pentylphenyl) ) -4-thiazolylmethyl group, 2- (3-n-hexylphenyl) -5-thiazolylmethyl group, 5- (3,4-dimethylphenyl) -4-thiazolylmethyl group, 4- (2,4,6-trimethylphenyl) ) -5-thiazolylmethyl group, 2- (4-methoxyphenyl) -4-thiazolylmethyl group, 2- (4-ethoxyphenyl) -5-thiazolylmethyl group, 2- (4-propoxyphenyl) -4-thiazolylmethyl group, 2 -(4-n-butoxyphenyl) -5-thiazolylmethyl group, 2- (2-thiazolyl) ethyl group, 2- (4-thiazolyl) ethyl group, 2- (5-thiazolyl) ethyl group, 2- [5- (2-n-pentyloxyphenyl) -4-thiazolyl] ethyl group, 2- [2- (2-n-hexyloxyphenyl) -5-thiazolyl] ethyl 2- [2- (2,5-dimethoxyphenyl) -4-thiazolyl] ethyl group, 2- [2- (2,4,6-trimethoxyphenyl) -5-thiazolyl] ethyl group, 2- (2 -Trifluoromethylphenyl) -4-thiazolylmethyl group, 2,4-di (trifluoromethyl) phenyl-5-thiazolylmethyl group, 2-trifluoromethoxyphenyl-4-thiazolylmethyl group, 2,3-di (trifluoromethoxy) ) Phenyl-5-thiazolylmethyl group, 2- (2-methyl-5-trifluoromethoxyphenyl-4-thiazolyl) ethyl group, 3- (2-thiazolyl) propyl group, 2- (4-thiazolyl) propyl group, 3 -(5-thiazolyl) propyl group, 3-[(2-methoxy-4-trifluoromethylphenyl) -4-thiazolyl]] propyl group 4- (2-thiazolyl) butyl group, 4- (4-thiazolyl) butyl group, 3- (5-thiazolyl) butyl group, 4- [4- (2-chloro-4-methylphenyl) -2-thiazolyl] Butyl group, 5- (2-thiazolyl) pentyl group, 5- [5- (2-fluoro-3-methoxyphenyl) -2-thiazolyl] pentyl group, 5- (4-thiazolyl) pentyl group, 5- (5 -Thiazolyl C1-6 alkyl group such as (thiazolyl) pentyl group, 5- (2-thiazolyl) hexyl group, 5- (4-thiazolyl) hexyl group, 5- (5-thiazolyl) hexyl group (on the thiazole ring, 1-2 phenyl groups [from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring. 1 to 5 groups, preferably 1 to 3 groups, which may be substituted] may be substituted.

  The C1-6 alkoxycarbonyl group is a group composed of the C1-6 alkoxy group defined above and a carbonyl group, such as a methoxycarbonyl group, an ethoxycarbonyl group, a propoxycarbonyl group, an isopropoxycarbonyl group, n-butoxycarbonyl group, isobutoxycarbonyl group, tert-butoxycarbonyl group, sec-butoxycarbonyl group, n-pentoxycarbonyl group, neopentoxycarbonyl group, n-hexyloxycarbonyl group, isohexyloxycarbonyl group, 3 -A methylpentoxycarbonyl group etc. can be mentioned.

  A benzoyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted; May be, for example, benzoyl group, 2-fluorobenzoyl group, 3-fluorobenzoyl group, 4-fluorobenzoyl group, 2,3-difluorobenzoyl group, 3,4-difluorobenzoyl group, 2-chloro Benzoyl group, 3-chlorobenzoyl group, 4-chlorobenzoyl group, 2,3-dichlorobenzoyl group, 3,4-dichlorobenzoyl group, 2,4,6-trichlorobenzoyl group, 4-iodobenzoyl group, 2,3 , 4,5,6-pentafluorobenzoyl group, 2-bromobenzoyl group, 3-bromobenzoyl group 4-bromobenzoyl group, 2,3-dibromobenzoyl group, 3,4-dibromobenzoyl group, 2-methylbenzoyl group, 3-methylbenzoyl group, 4-methylbenzoyl group, 2,3-dimethylbenzoyl group, 3, 4-dimethylbenzoyl group, 3,4,5-trimethylbenzoyl group, 2-trifluoromethylbenzoyl group, 3-trifluoromethylbenzoyl group, 4-trifluoromethylbenzoyl group, 2,3-ditrifluoromethylbenzoyl group, 3,4-ditrifluoromethylbenzoyl group, 2-methoxybenzoyl group, 3-methoxybenzoyl group, 4-methoxybenzoyl group, 3,4-dimethoxybenzoyl group, 2,4,6-trimethoxybenzoyl group, 2-tri Fluoromethoxybenzoyl group, 3-trifluoromethoxybenzoyl 4-trifluoromethoxybenzoyl group, 2-methoxy-3-fluorobenzoyl group, 3-methyl-4-chlorobenzoyl, 3-trifluoromethoxy-4-methylbenzoyl group, 2-methoxy-4-trifluoromethylbenzoyl A benzoyl group such as a group (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, a halogen-substituted or unsubstituted C1-6 alkoxy group, and 1-5 Or preferably 1 to 3 may be substituted).

  Phenylcarbamoyl group (on the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. Is a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring. A group consisting of 5, preferably 1 to 3 optionally substituted aniline, N-C1-6 alkylaniline or N-phenyl C1-6 alkylaniline and a carbonyl group, such as a phenylcarbamoyl group , 2-fluorophenylcarbamoyl group, 3-fluorophenylcarbamoyl group, 4-fluorophenylcarbamoyl 2-chlorophenylcarbamoyl group, 3-chlorophenylcarbamoyl group, 4-chlorophenylcarbamoyl group, 2-bromophenylcarbamoyl group, 3-bromophenylcarbamoyl group, 4-bromophenylcarbamoyl group, 2-iodophenylcarbamoyl group, 3-iodo Phenylcarbamoyl group, 4-iodophenylcarbamoyl group, 2,3-difluorophenylcarbamoyl group, 3,4-difluorophenylcarbamoyl group, 3,5-difluorophenylcarbamoyl group, 2,4-difluorophenylcarbamoyl group, 2,6 -Difluorophenylcarbamoyl group, 2,3-dichlorophenylcarbamoyl group, 3,4-dichlorophenylcarbamoyl group, 3,5-dichlorophenylcarbamoyl group, 2,4-dichlorophenylcarbamoyl group Vamoyl group, 2,6-dichlorophenylcarbamoyl group, 3,4,5-trifluorophenylcarbamoyl group, 2,3,4,5,6-pentafluorophenylcarbamoyl group, 3,4,5-trichlorophenylcarbamoyl group, 2,4,6-trifluorophenylcarbamoyl group, 2,4,6-trichlorophenylcarbamoyl group, 2-methylphenylcarbamoyl group, 3-methylphenylcarbamoyl group, 4-methylphenylcarbamoyl group, 2-methyl-3- Chlorophenylcarbamoyl group, 3-methyl-4-chlorophenylcarbamoyl group, 2-chloro-4-methylphenylcarbamoyl group, 2-methyl-3-fluorophenylcarbamoyl group, 2-trifluoromethylphenylcarbamoyl group, 3-trifluoromethyl Phenylcal Vamoyl group, N-methyl-N-phenylcarbamoyl group, N- (2-fluorophenyl) -N-methylcarbamoyl group, N- (3-fluorophenyl) -N-methylcarbamoyl group, N- (4-fluorophenyl) ) -N-methylcarbamoyl group, N- (2-chlorophenyl) -N-methylcarbamoyl group, N- (3-chlorophenyl) -N-methylcarbamoyl group, N- (4-chlorophenyl) -N-methylcarbamoyl group, N- (4-bromophenyl) -N-methylcarbamoyl group, N- (2-iodophenyl) -N-methylcarbamoyl group, N- (3-iodophenyl) -N-methylcarbamoyl group, N- (4- Iodophenyl) -N-methylcarbamoyl group, N- (2,3-difluorophenyl) -N-methylcarbamoyl group, N- ( , 4-Difluorophenyl) -N-methylcarbamoyl group, N- (3,5-difluorophenyl) -N-methylcarbamoyl group, N- (2,4-difluorophenyl) -N-methylcarbamoyl group, N- ( 2,6-difluorophenyl) -N-methylcarbamoyl group, N- (2,3-dichlorophenyl) -N-methylcarbamoyl group, N- (3,4-dichlorophenyl) -N-methylcarbamoyl group, N- (3 , 5-dichlorophenyl) -N-methylcarbamoyl group, N- (2,4-dichlorophenyl) -N-methylcarbamoyl group, N- (2,6-dichlorophenyl) -N-methylcarbamoyl group, N- (3,4 , 5-trifluorophenyl) -N-methylcarbamoyl group, N- (3,4,5-trichlorophenyl) -N-methylcarba Yl group, N- (2,4,6-trifluorophenyl) -N-methylcarbamoyl group, N- (2,4,6-trichlorophenyl) -N-methylcarbamoyl group, N- (2-methylphenyl) -N-methylcarbamoyl group, N- (3-methylphenyl) -N-methylcarbamoyl group, N- (4-methylphenyl) -N-methylcarbamoyl group, N- (2-methyl-3-chlorophenyl) -N -Methylcarbamoyl group, N- (3-methyl-4-chlorophenyl) -N-methylcarbamoyl group, N- (2-chloro-4-methylphenyl) -N-methylcarbamoyl group, N- (2-methyl-3) -Fluorophenyl) -N-methylcarbamoyl group, N- (2-trifluoromethylphenyl) -N-methylcarbamoyl group, N- (4-trifluoromethylphenyl group) Enyl) -N-methylcarbamoyl group, N-benzyl-N-phenylcarbamoyl group, N-benzyl-N- (2-fluorophenyl) carbamoyl group, N-benzyl-N- (3-fluorophenyl) carbamoyl group, N -Benzyl-N- (4-fluorophenyl) carbamoyl group, N-benzyl-N- (2-chlorophenyl) carbamoyl group, N-benzyl-N- (3-chlorophenyl) carbamoyl group, N-benzyl-N- (4 -Chlorophenyl) carbamoyl group, N-benzyl-N- (2-bromophenyl) carbamoyl group, N-benzyl-N- (3-bromophenyl) carbamoyl group, N-benzyl-N- (4-bromophenyl) carbamoyl group N-benzyl-N- (2-iodophenyl) carbamoyl group, N-benzyl-N- (3 Iodophenyl) carbamoyl group, N-benzyl-N- (4-iodophenyl) carbamoyl group, N-benzyl-N- (2,3-difluorophenyl) carbamoyl group, N-benzyl-N- (3,4-difluoro) Phenyl) carbamoyl group, N-benzyl-N- (3,5-difluorophenyl) carbamoyl group, N-benzyl-N- (2,4-difluorophenyl) carbamoyl group, N-benzyl-N- (2,6- Difluorophenyl) carbamoyl group, N-benzyl-N- (2,3-dichlorophenyl) carbamoyl group, N-benzyl-N- (3,4-dichlorophenyl) carbamoyl group, N-benzyl-N- (3,5-dichlorophenyl) ) Carbamoyl group, N-benzyl-N- (2,4-dichlorophenyl) carbamoyl group, N-ben Ru-N- (2,6-dichlorophenyl) carbamoyl group, N-benzyl-N- (3,4,5-trifluorophenyl) carbamoyl group, N-benzyl-N- (3,4,5-trichlorophenyl) Carbamoyl group, N-benzyl-N- (2,4,6-trifluorophenyl) carbamoyl group, N-benzyl-N- (2,4,6-trichlorophenyl) carbamoyl group, N-benzyl-N- (2 -Methylphenyl) carbamoyl group, N-benzyl-N- (3-methylphenyl) carbamoyl group, N-benzyl-N- (4-methylphenyl) carbamoyl group, N-benzyl-N- (2-methyl-3- Chlorophenyl) carbamoyl group, N-benzyl-N- (3-methyl-4-chlorophenyl) carbamoyl group, N-benzyl-N- (2-chloro-4) -Methylphenyl) carbamoyl group, N-benzyl-N- (2-methyl-3-fluorophenyl) carbamoyl group, N-benzyl-N- (2-trifluoromethylphenyl) carbamoyl group, N-benzyl-N- ( 3-trifluoromethylphenyl) carbamoyl group, N-benzyl-N- (4-trifluoromethylphenyl) carbamoyl group, 2-pentafluoroethylphenylcarbamoyl group, 3-pentafluoroethylphenylcarbamoyl group, 4-pentafluoroethyl Phenylcarbamoyl group, 2-isopropylphenylcarbamoyl group, 3-isopropylphenylcarbamoyl group, 4-isopropylphenylcarbamoyl group, 2-tert-butylphenylcarbamoyl group, 3-tert-butylphenylcarbamoyl group, 4-t rt-butylphenylcarbamoyl group, 2-sec-butylphenylcarbamoyl group, 3-sec-butylphenylcarbamoyl group, 4-sec-butylphenylcarbamoyl group, 2-n-heptafluoropropylphenylcarbamoyl group, 3-n-hepta Fluoropropylphenylcarbamoyl group, 4-n-heptafluoropropylphenylcarbamoyl group, 4-pentylphenylcarbamoyl group, 4-hexylphenylcarbamoyl group, 2,4-dimethylphenylcarbamoyl group, 2,4,6-trimethylphenylcarbamoyl group 3,4-dimethoxyphenylcarbamoyl group, 3,4,5-trimethoxyphenylcarbamoyl group, 2-methoxyphenylcarbamoyl group, 3-methoxyphenylcarbamoyl group, 4-methoxyphenyl Rubamoyl group, 2-methoxy-3-chlorophenylcarbamoyl group, 2-fluoro-3-methoxyphenylcarbamoyl group, 2-fluoro-4-methoxyphenylcarbamoyl group, 2,6-dimethoxyphenylcarbamoyl group, 2,3,4- Trifluorophenylcarbamoyl group, 3,4,5-trifluorophenylcarbamoyl group, 2-trifluoromethoxyphenylcarbamoyl group, 3-trifluoromethoxyphenylcarbamoyl group, 4-trifluoromethoxyphenylcarbamoyl group, 2-pentafluoroethoxy Phenylcarbamoyl group, 3-pentafluoroethoxyphenylcarbamoyl group, 4-pentafluoroethoxyphenylcarbamoyl group, 2-isopropoxyphenylcarbamoyl group, 3-isopropoxyphenylcarbon Vamoyl group, 4-isopropoxyphenylcarbamoyl group, 2-tert-butoxyphenylcarbamoyl group, 3-tert-butoxyphenylcarbamoyl group, 4-tert-butoxyphenylcarbamoyl group, 2-sec-butoxyphenylcarbamoyl group, 3-sec -Butoxyphenylcarbamoyl group, 4-sec-butoxyphenylcarbamoyl group, 2-n-heptafluoropropoxyphenylcarbamoyl group, 3-n-heptafluoropropoxyphenylcarbamoyl group, 4-n-heptafluoropropoxyphenylcarbamoyl group, 4- Examples thereof include an n-pentyloxyphenylcarbamoyl group and a 4-n-hexyloxyphenylcarbamoyl group.

  Examples of the 4H-1,3-benzodioxinyl group (at least one halogen atom may be substituted on the 4H-1,3-benzodioxin ring) include (2-, 4- , 5-, 6-, 7- or 8-) 4H-1,3-benzodioxinyl group, 2,2,4,4-tetrafluoro- (5-, 6-, 7- or 8-) 4H -1,3-benzodioxinyl group, 2-chloro- (2-, 4-, 5-, 6-, 7- or 8-) 4H-1,3-benzodioxinyl group, 4-bromo- (2-, 4-, 5-, 6-, 7- or 8-) 4H-1,3-benzodioxinyl group, 2,4-dichloro- (2-, 4-, 5-, 6-, 7- or 8-) 4H-1,3-benzodioxinyl group, 2,4,6-trifluoro- (2-, 4-, 5-, 7- or 8-) 4H-1,3-benzodi Examples thereof include 4H-1,3-benzodioxinyl groups such as an oxynyl group (1 to 4 halogen atoms may be substituted on the 4H-1,3-benzodioxin ring).

  Examples of the benzothiazolyl group (at least one C1-6 alkyl group may be substituted on the benzothiazole ring) include (2-, 4-, 5-, 6-, or 7-) benzothiazolyl. Group, 2-methyl-5-benzothiazolyl group, 4-ethyl-6-benzothiazolyl group, 5-propyl-7-benzothiazolyl group, 6-tert-butyl-2-benzothiazolyl group, 7-pentyl-4-benzothiazolyl group, 2 A benzothiazolyl group such as -hexyl-5-benzothiazolyl group, 2,4-dimethyl-5-benzothiazolyl group, 2,4,6-trimethyl-7-benzothiazolyl group (1 to 3 C1-6 on the benzothiazole ring) An alkyl group may be substituted).

  Examples of the 2,3-dihydro-1H-indenyl group (at least one oxo group may be substituted on the 2,3-dihydro-1H-indene ring) include, for example, 2,3-dihydro- 2,3-dihydro-1H-indenyl groups such as 1H-indenyl group, 1-oxo-2,3-dihydro-1H-indenyl group, 1,3-dioxo-2,3-dihydro-1H-indenyl group (2 , 3-dihydro-1H-indane ring may be substituted with 1 to 2 oxo groups).

  A phenyl C2-6 alkenyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; The seed may be substituted) means 1 to 5 groups selected from unsubstituted or halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups. , Preferably a group composed of 1 or 2 phenyl groups substituted by 1 to 3 and an alkenyl group having 2 to 6 carbon atoms and 1 to 3 double bonds. The phenyl C2-6 alkenyl group includes both trans and cis isomers. Examples of such phenyl C2-6 alkenyl groups include 2-phenylvinyl group, 3-phenyl-2-propenyl group (common name: cinnamyl group), 3,3-diphenyl-2-propenyl group, and 3-phenyl. 2-methyl-2-propenyl group, 4-phenyl-2-butenyl group, 4,4-diphenyl-2-butenyl group, 4-phenyl-3-butenyl group, 4-phenyl-1,3-butadienyl group, 5-phenyl-1,3,5-hexatrienyl group, 5,5-diphenyl-3-pentenyl group, 6,6-diphenyl-2-hexenyl group, 6-phenyl-1,3-hexadienyl group, 3- (2-fluorophenyl) -2-propenyl group, 3- (3-fluorophenyl) -2-propenyl group, 3- (4-fluorophenyl) -2-propenyl group, 3- (2, -Difluorophenyl) -2-propenyl group, 3- (2,3,4,5,6-pentafluorophenyl) -2-propenyl group, 3- (2,4-difluorophenyl) -2-propenyl group, 3 -(3,4-difluorophenyl) -2-propenyl group, 3- (3,5-difluorophenyl) -2-propenyl group, 3- (2-chlorophenyl) -2-propenyl group, 3- (3-chlorophenyl) ) -2-propenyl group, 3- (4-chlorophenyl) -2-propenyl group, 3- (2,3-dichlorophenyl) -2-propenyl group, 3- (2,4-dichlorophenyl) -2-propenyl group, 3- (3,4-dichlorophenyl) -2-propenyl group, 3- (3,5-dichlorophenyl) -2-propenyl group, 3- (2,6-dichlorophenyl) -2-propenyl group Group, 3- (3,6-dichlorophenyl) -2-propenyl group, 3- (3,5,6-trichlorophenyl) -2-propenyl group, 3- (2,4,5-trichlorophenyl) -2 -Propenyl group, 3- (2-bromophenyl) -2-propenyl group, 3- (3-bromophenyl) -2-propenyl group, 3- (4-bromophenyl) -2-propenyl group, 3- (2 -Methylphenyl) -2-propenyl group, 3- (3-methylphenyl) -2-propenyl group, 3- (4-methylphenyl) -2-propenyl group, 3- (2-trifluoromethylphenyl) -2 -Propenyl group, 3- (2-fluoro-4-bromophenyl) -2-propenyl group, 3- (4-chloro-3-fluorophenyl) -2-propenyl group, 3- (2,3,4-triphenyl) Chlorophenyl) 2-propenyl group, 3- (2,4,6-trichlorophenyl) -2-propenyl group, 3- (4-ethylphenyl) -2-propenyl group, 3- (4-n-hexylphenyl) -2 -Propenyl group, 3- (4-isopropylphenyl) -2-propenyl group, 3- (4-n-butylphenyl) -2-propenyl group, 3- (2,4-dimethylphenyl) -2-propenyl group, 3- (2,3-dimethylphenyl) -2-propenyl group, 3- (2,6-dimethylphenyl) -2-propenyl group, 3- (3,5-dimethylphenyl) -2-propenyl group, 3- (2,5-dimethylphenyl) -2-propenyl group, 3- (2,4,6-trimethylphenyl) -2-propenyl group, 3- (3,5-ditrifluoromethylphenyl) -2-propenyl group, 3- ( -N-butoxyphenyl) -2-propenyl group, 3- (2,4-dimethoxyphenyl) -2-propenyl group, 3- (2,3-dimethoxyphenyl) -2-propenyl group, 3- (2,6 -Dimethoxyphenyl) -2-propenyl group, 3- (3,5-dimethoxyphenyl) -2-propenyl group, 3- (2,5-dimethoxyphenyl) -2-propenyl group, 3- (3,5-ditri Fluoromethoxyphenyl) -2-propenyl group, 3- (3-chloro-4-methoxyphenyl) -2-propenyl group, 3- (2-chloro-4-trifluoromethoxyphenyl) -2-propenyl group, 3- (3-methyl-4-fluorophenyl) -2-propenyl group, 3- (2-methyl-4-fluorophenyl) -2-propenyl group, 3- (3-trifluoromethyl-4 Fluorophenyl) -2-propenyl group, 3- (3-trifluoromethyl-2-fluorophenyl) -2-propenyl group, 3- (4-bromo-3-trifluoromethylphenyl) -2-propenyl group, 3 -(4-Chloro-3-trifluoromethylphenyl) -2-propenyl group, 3- (3-trifluoromethylphenyl) -2-propenyl group, 3- (2-trifluoromethylphenyl) -2-propenyl group 3- (4-trifluoromethylphenyl) -2-propenyl group, 3- (2-trifluoromethoxyphenyl) -2-propenyl group, 3- (3-trifluoromethoxyphenyl) -2-propenyl group, 3 -(4-trifluoromethoxyphenyl) -2-propenyl group, 3- (2-methoxyphenyl) -2-propenyl group, 3- (3-metho Xylphenyl) -2-propenyl group, 3- (4-methoxyphenyl) -2-propenyl group, 3- (4-n-hexyloxyphenyl) -2-propenyl group, 3- (3,4-dimethoxyphenyl)- 2-propenyl group, 3- (3,5-dimethoxyphenyl) -2-propenyl group, 4- (4-chlorophenyl) -2-butenyl group, 4- (4-chlorophenyl) -3-butenyl group, 5- ( 4-chlorophenyl) -2-pentenyl group, 5- (4-chlorophenyl) -4-pentenyl group, 5- (4-chlorophenyl) -3-pentenyl group, 6- (4-chlorophenyl) -5-hexenyl group, 6 -(4-chlorophenyl) -4-hexenyl group, 6- (4-chlorophenyl) -3-hexenyl group, 6- (4-chlorophenyl) -3-hexenyl group, etc. Door can be.

  A phenyl group (on the phenyl ring, a C1-4 alkylenedioxy group, a cyano group, a nitro group, an amino group that may have a C1-6 alkyl group as a substituent, and a C1-6 alkyl group as a substituent) An amino-substituted sulfonyl group, a C1-6 alkoxycarbonyl group, a C1-6 alkylthio group, a phenoxy group, a phenyl C1-6 alkoxy group, a pyrrolidinyl group (on the pyrrolidine ring, at least one oxo group is substituted) ), An imidazolyl group, an isoxazolyl group, an oxazolyl group, a phenyl C1-6 alkyl group, a phenyl group, an amino C1-6 alkyl group which may have a C1-6 alkyl group as a substituent, a pyrrolidinyl C1-6 alkoxy group, Halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen position Alternatively, as a group selected from the group consisting of unsubstituted C1-6 alkoxy groups, which may be substituted, for example, a phenyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted) A substituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), a 4-cyanophenyl group, 3- Cyanophenyl group, 2-cyanophenyl group, 3,4-dicyanophenyl group, 2,4,6-tricyanophenyl group, 4-nitrophenyl group, 3-nitrophenyl group, 2-nitrophenyl group, 3,4 -Dinitrophenyl group, 2,4,6-trinitrophenyl group, 4-dimethylaminophenyl group, 3-methylaminophenyl group, 2-N-ethyl-N-me Ruaminophenyl group, 2,4-di (methylamino) phenyl group, 2,4,6-tri (methylamino) phenyl group, 4-dimethylaminosulfonylphenyl group, 3-methylaminosulfonylphenyl group, 2-N -Ethyl-N-methylaminosulfonylphenyl group, 2,4-di (methylaminosulfonyl) phenyl group, 2,4,6-tri (methylaminosulfonyl) phenyl group, 4-ethoxycarbonylphenyl group, 4-ethoxycarbonyl Phenyl group, 3-methoxycarbonylphenyl group, 2-propoxycarbonylphenyl group, 2,4-diethoxycarbonylphenyl group, 2,4,6-triethoxycarbonylphenyl group, 4-methylthiophenyl group, 3-ethylthiophenyl Group, 2-methylthiophenyl group, 3,4-dimethylthiophenyl group Group, 2,4,6-trimethylthiophenyl group, 3,4-ethylenedioxyphenyl group, 3,4-methylenedioxyphenyl group, 4-diisopropylaminomethylphenyl group, 3-methylaminomethylphenyl group, 2 -Ethylaminomethylphenyl group, 2,4-dimethylaminomethylphenyl group, 2,4,6-triethylaminomethylphenyl group, 4-phenoxyphenyl group, 3-phenoxyphenyl group, 2-phenoxyphenyl group, 2,4 -Diphenoxyphenyl group, 3,4,5-triphenoxyphenyl group, 4-benzyloxyphenyl group, 3-benzyloxyphenyl group, 2-benzyloxyphenyl group, 2,4-dibenzyloxyphenyl group, 2, 4,6-tribenzyloxyphenyl group, 4- (2-oxo-1-pyrrolidinyl) phen Group, 4- (5-oxazolyl) phenyl group, 4- (5-isoxazolyl) phenyl group, 4- (1-imidazolyl) phenyl group, 4-benzylphenyl group, 3-benzylphenyl group, 2-benzylphenyl group 3,4-dibenzylphenyl group, 2,4,6-tribenzylphenyl group, 4-biphenyl group, 3-biphenyl group, 2-biphenyl group, 2,4-diphenylphenyl group, 2,4,6- Phenyl such as triphenylphenyl group, 2- (2-imidazolyl) -4-phenoxyphenyl group, 3- (2-oxazolyl) -4-benzyloxyphenyl group, 4- (3-isoxazolyl) -2-benzylphenyl group Group (on the phenyl ring, C1-4 alkylenedioxy group, cyano group, nitro group, 1-2 C1-6 alkyl groups as substituents) Amino group, amino substituted sulfonyl group having 1 to 2 C1-6 alkyl groups as a substituent, C1-6 alkoxycarbonyl group, C1-6 alkylthio group, phenoxy group, phenyl C1-6 alkoxy group Pyrrolidinyl group (at least one oxo group may be substituted on the pyrrolidine ring), imidazolyl group, isoxazolyl group, oxazolyl group, phenyl C1-6 alkyl group, phenyl group, C1-6 as substituent From the group consisting of amino C1-6 alkyl groups, pyrrolidinyl C1-6 alkoxy groups, which may have alkyl groups, halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups 1 to 5, preferably 1 to 3 selected groups may be substituted. ).

  Examples of the phenyl group [halogen may be substituted on the phenyl ring] include, for example, a phenyl group, 2-fluorophenyl group, 3-fluorophenyl group, 4-fluorophenyl group, 2-chlorophenyl group, 3 -Chlorophenyl group, 4-chlorophenyl group, 2-bromophenyl group, 3-bromophenyl group, 4-bromophenyl group, 2-iodophenyl group, 3-iodophenyl group, 4-iodophenyl group, 2,3-difluoro Phenyl group, 3,4-difluorophenyl group, 3,5-difluorophenyl group, 2,4-difluorophenyl group, 2,6-difluorophenyl group, 2,3-dichlorophenyl group, 3,4-dichlorophenyl group, 3 , 5-dichlorophenyl group, 2,4-dichlorophenyl group, 2,6-dichlorophenyl group, 3,4,5-tri Fluorophenyl group, 3,4,5-trichlorophenyl group, 2,4,6-trifluorophenyl group, 2,4,6-trichlorophenyl group, 2-fluoro-4-bromophenyl group, 4-chloro-3- Fluorophenyl group, 2,3,4-trichlorophenyl group, 3,4,5-trifluorophenyl group, 2,4,6-tribromophenyl group, 2,3,4,5,6-pentafluorophenyl group And a phenyl group which may be substituted with 1 to 5 halogen atoms on the phenyl ring.

  Phenyl C1-6 alkoxy substituted C1-6 alkyl group (on the phenyl ring, a C1-4 alkylenedioxy group, a halogen atom, a cyano group, a phenyl group, a phenyl C1-6 alkoxy group, a phenyl C2-6 alkenyl group, phenoxy At least one selected from the group consisting of a group, a C1-6 alkylthio group, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. ), For example, a phenyl C1-6 alkoxy-substituted C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) In addition, at least one group selected from the group consisting of may be substituted) Nylmethoxymethyl group, 3-cyanophenylmethoxymethyl group, 2-cyanophenylmethoxymethyl group, 2,4-dicyanophenylmethoxymethyl group, 2,4,6-tricyanophenylmethoxymethyl group, 4-biphenylmethoxymethyl group 3-biphenylmethoxymethyl group, 2-biphenylmethoxymethyl group, 2,4-diphenylphenylmethoxymethyl group, 2,4,6-triphenylphenylmethoxymethyl group, 4-phenoxyphenylmethoxymethyl group, 3-phenoxyphenyl Methoxymethyl group, 2-phenoxyphenylmethoxymethyl group, 3,4-diphenoxyphenylmethoxymethyl group, 3,4,5-triphenoxyphenylmethoxymethyl group, 4-methylthiophenylmethoxymethyl group, 3-ethylthiophenylmethoxy Me Group, 2-methylthiophenylmethoxymethyl group, 2,4-dimethylthiophenylmethoxymethyl group, 2,4,6-trimethylthiophenylmethoxymethyl group, 4-cyano-2-phenylphenylmethoxymethyl group, 3-phenoxy -4-methylthiophenylmethoxymethyl group, 3-trifluoromethyl-4-methylthiophenylmethoxymethyl group, 3-trifluoromethoxy-2-phenoxyphenylmethoxymethyl group, 3,4-methylenedioxyphenylmethoxymethyl group, 4 -Benzyloxyphenylmethoxymethyl group, 3,4-dibenzyloxyphenylmethoxymethyl group, 2,4,6-tribenzyloxyphenylmethoxymethyl group, 3-benzyloxyphenylmethoxymethyl group, 2-benzyloxyphenylmethoxymethyl Base Phenyl such as 4-styrylphenylmethoxymethyl group, 3-styrylphenylmethoxymethyl group, 2-styrylphenylmethoxymethyl group, 2,4-distyrylphenylmethoxymethyl, 2,4,6-tristyrylphenylmethoxymethyl group, etc. C1-6 alkoxy-substituted C1-6 alkyl group (on the phenyl ring, the alkyl moiety is a linear or branched alkylenedioxy group having 1 to 4 carbon atoms, a halogen atom, a cyano group, a phenyl group, or an alkoxy moiety. Consists of a phenylalkoxy group which is a linear or branched alkoxy having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms and having at least 1 to 3 double bonds, and includes both trans and cis isomers Phenylalkenyl group, phenoxy group, linear or branched alkylthio group having 1 to 6 carbon atoms, halogen substitution Is a group selected from the group consisting of an unsubstituted straight-chain or branched alkyl group having 1 to 6 carbon atoms and a halogen-substituted or unsubstituted straight-chain or branched alkoxy group having 1 to 6 carbon atoms. 1 to 5, preferably 1 to 3 may be substituted (in the case where the substituent is a C1 to 4 alkylenedioxy group, 1 to 2 may be substituted).

  Phenyl C1-6 alkoxy group (on the phenyl ring, cyano group, phenyl group, C1-6 alkoxycarbonyl group, phenoxy group, C1-6 alkylthio group, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and Examples of the halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted with at least one group selected from the group consisting of a C1-6 alkoxy group, for example, a phenyl C1-6 alkoxy group (on the phenyl ring, halogen In addition, at least one group selected from the group consisting of an atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted). -Cyanophenylmethoxy group, 3-cyanobenzyloxy group, 2-cyanobenzyloxy group, 2,4-dicyanobenzyl Xyl group, 2,3,4-tricyanobenzyloxy group, 4-biphenylmethoxy group, 3-biphenylmethoxy group, 2-biphenylmethoxy group, 2,4-diphenylbenzyloxy group, 2,4,6-triphenyl Benzyloxy group, 4-methoxycarbonylbenzyloxy group, 3-ethoxycarbonylbenzyloxy group, 2-methoxycarbonylbenzyloxy group, 3,4-diethoxycarbonylbenzyloxy group, 3,4,5-trimethoxycarbonylbenzyloxy group Group, 3-phenoxybenzyloxy group, 2-phenoxybenzyloxy group, 4-phenoxybenzyloxy group, 2,4-diphenoxybenzyloxy group, 2,4,6-triphenoxybenzyloxy group, 4-methylthiobenzyloxy Group, 3-methylthiobenzyloxy group, -Methylthiobenzyloxy group, 3,4-dimethylthiobenzyloxy group, 2,5,6-trimethylthiobenzyloxy group, 3-cyano-4-bibenzyloxy group, 4-ethoxycarbonyl-3-phenoxybenzyloxy group 3-methylthio-4-ethylbenzyloxy group, di (4-trifluoromethoxyphenyl) methoxy group, di (4-trifluoromethylphenyl) methoxy group, di (4-chlorophenyl) methoxy group, di (3-methoxy Phenyl) methoxy group, di (2-methylphenyl) methoxy group, di (2,4-dimethoxyphenyl) methoxy group, di (3,4-dimethylphenyl) methoxy group, di (2,4,6-trimethoxyphenyl) ) Methoxy group, di (3,4,5-trifluoromethylphenyl) methoxy group, di (2,4,6-trifluoro) C1-6 alkoxy groups substituted with 1 to 2 phenyl groups such as (olophenyl) methoxy group and 1- (4-trifluoromethoxyphenyl) -1- (2,4-dichlorophenyl) methoxy group (on the phenyl ring, Consists of cyano group, phenyl group, C1-6 alkoxycarbonyl group, phenoxy group, C1-6 alkylthio group, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group 1 to 5, preferably 1 to 3 groups selected from the group may be substituted.

  A phenyl C2-6 alkenyloxy group (on the phenyl ring, at least a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; 1 type may be substituted) means 1 to 5 groups selected from unsubstituted or halogen atoms, halogen C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups, preferably It is a group composed of 1 to 3 substituted phenyl groups and an alkenyl group having 2 to 6 carbon atoms and at least 1 to 3 double bonds. The phenyl C2-6 alkenyloxy group includes both trans form and cis form. Examples of such phenyl C2-6 alkenyloxy groups include 2-phenylvinyloxy group, 3-phenyl-2-propenyloxy group (common name: cinnamyloxy group), 4-phenyl-2-butenyloxy group, 4-phenyl-3-butenoxy group, 4-phenyl-1,3-butadienyloxy group, 5-phenyl-1,3,5-hexatrienyloxy group, 3- (2-fluorophenyl) -2- Propenyloxy group, 3- (3-fluorophenyl) -2-propenyloxy group, 3- (4-fluorophenyl) -2-propenyloxy group, 3- (2,3-difluorophenyl) -2-propenyloxy group 3- (2,3,4,5,6-pentafluorophenyl) -2-propenyloxy group, 3- (2,4-difluorophenyl) -2-pro Nyloxy group, 3- (3,4-difluorophenyl) -2-propenyloxy group, 3- (3,5-difluorophenyl) -2-propenyloxy group, 3- (2-chlorophenyl) -2-propenyloxy group 3- (3-chlorophenyl) -2-propenyloxy group, 3- (4-chlorophenyl) -2-propenyloxy group, 3- (2,3-dichlorophenyl) -2-propenyloxy group, 3- (2, 4-dichlorophenyl) -2-propenyloxy group, 3- (3,4-dichlorophenyl) -2-propenyloxy group, 3- (3,5-dichlorophenyl) -2-propenyloxy group, 3- (2-bromophenyl) ) -2-propenyloxy group, 3- (3-bromophenyl) -2-propenyloxy group, 3- (4-bromophenyl) -2-propene Ruoxy group, 3- (2-methylphenyl) -2-propenyloxy group, 3- (3-methylphenyl) -2-propenyloxy group, 3- (4-methylphenyl) -2-propenyloxy group, 3- (2-trifluoromethylphenyl) -2-propenyloxy group, 3- (2-fluoro-4-bromophenyl) -2-propenyloxy group, 3- (4-chloro-3-fluorophenyl) -2-propenyl Oxy group, 3- (2,3,4-trichlorophenyl) -2-propenyloxy group, 3- (2,4,6-trichlorophenyl) -2-propenyloxy group, 3- (4-isopropylphenyl)- 2-propenyloxy group, 3- (4-n-butylphenyl) -2-propenyloxy group, 3- (2,4-dimethylphenyl) -2-propenyloxy group, 3 -(2,3-dimethylphenyl) -2-propenyloxy group, 3- (2,6-dimethylphenyl) -2-propenyloxy group, 3- (3,5-dimethylphenyl) -2-propenyloxy group, 3- (2,5-dimethylphenyl) -2-propenyloxy group, 3- (2,4,6-trimethylphenyl) -2-propenyloxy group, 3- (3,5-ditrifluoromethylphenyl) -2 -Propenyloxy group, 3- (4-n-butoxyphenyl) -2-propenyloxy group, 3- (2,4-dimethoxyphenyl) -2-propenyloxy group, 3- (2,3-dimethoxyphenyl)- 2-propenyloxy group, 3- (2,6-dimethoxyphenyl) -2-propenyloxy group, 3- (3,5-dimethoxyphenyl) -2-propenyloxy group, 3- 2,5-dimethoxyphenyl) -2-propenyloxy group, 3- (3,5-ditrifluoromethoxyphenyl) -2-propenyloxy group, 3- (3-chloro-4-methoxyphenyl) -2-propenyloxy Group, 3- (2-chloro-4-trifluoromethoxyphenyl) -2-propenyloxy group, 3- (3-methyl-4-fluorophenyl) -2-propenyloxy group, 3- (4-bromo-3 -Trifluoromethylphenyl) -2-propenyloxy group, 3- (3-trifluoromethylphenyl) -2-propenyloxy group, 3- (4-trifluoromethylphenyl) -2-propenyloxy group, 3- ( 2-trifluoromethoxyphenyl) -2-propenyloxy group, 3- (3-trifluoromethoxyphenyl) -2-propenyloxy Si group, 3- (4-trifluoromethoxyphenyl) -2-propenyloxy group, 3- (2-methoxyphenyl) -2-propenyloxy group, 3- (3-methoxyphenyl) -2-propenyloxy group, 3- (4-methoxyphenyl) -2-propenyloxy group, 3- (3,4-dimethoxyphenyl) -2-propenyloxy group, 3- (3,5-dimethoxyphenyl) -2-propenyloxy group, 4 -(4-chlorophenyl) -2-butenyloxy group, 4- (4-chlorophenyl) -3-butenyloxy group, 5- (4-chlorophenyl) -2-pentenyloxy group, 5- (4-chlorophenyl) -4-pentenyl Oxy group, 5- (4-chlorophenyl) -3-pentenyloxy group, 6- (4-chlorophenyl) -5-hexenyloxy group, 6- (4-Chlorophenyl) -4-hexenyloxy group, 6- (4-chlorophenyl) -3-hexenyloxy group, 6- (4-chlorophenyl) -3-hexenyloxy group and the like can be mentioned.

  As the C1-6 alkyl group which may have a hydroxyl group as a substituent, in addition to the C1-6 alkyl group, a hydroxymethyl group, a 2-hydroxyethyl group, a 1-hydroxyethyl group, a 3-hydroxypropyl group, 2 , 3-dihydroxypropyl group, 4-hydroxybutyl group, 3,4-dihydroxybutyl group, 1,1-dimethyl-2-hydroxyethyl group, 5-hydroxypentyl group, 6-hydroxyhexyl group, 2-methyl-3 Examples thereof include C1-6 linear or branched alkyl groups having 1 to 3 hydroxyl groups such as -hydroxypropyl group and 2,3,4-trihydroxybutyl group.

  The C1-6 alkanoyl group is a group derived from an aliphatic carboxylic acid having 1 to 6 carbon atoms. For example, a formyl group, an acetyl group, a propionyl group, a butyryl group, a pentanoyl group, a hexanoyl group Etc.

  Phenyl C1-6 alkoxycarbonyl group [on the phenyl ring, at least a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; Is optionally selected from the group consisting of a halogen atom as defined above, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. A group composed of a phenyl C1-6 alkoxy group optionally substituted with 1 to 5, preferably 1 to 3 groups, and a carbonyl group, such as a benzyloxycarbonyl group or a 2-phenylethoxycarbonyl group 3-phenylpropoxycarbonyl group, 2-phenylpropoxycarbonyl group, 4-phenylbutoxycar Nyl group, 5-phenylpentoxycarbonyl group, 4-phenylpentoxycarbonyl group, 6-phenylhexyloxycarbonyl group, 2-fluorobenzyloxycarbonyl group, 3-fluorobenzyloxycarbonyl group, 4-fluorobenzyloxycarbonyl group 2- (2-fluorophenyl) ethoxycarbonyl group, 2- (3-fluorophenyl) ethoxycarbonyl group, 2- (4-fluorophenyl) ethoxycarbonyl group, 2-chlorobenzyloxycarbonyl group, 3-chlorobenzyloxy Carbonyl group, 4-chlorobenzyloxycarbonyl group, 2-fluoro-4-bromobenzyloxycarbonyl group, 4-chloro-3-fluorobenzyloxycarbonyl group, 2,3,4-trichlorobenzyloxycarbonyl group, 3,4 5-trifluorobenzyloxycarbonyl group, 2,3,4,5,6-pentafluorobenzyloxycarbonyl group, 2,4,6-trichlorobenzyloxycarbonyl group, 4-isopropylbenzyloxycarbonyl group, 4-n- Butylbenzyloxycarbonyl group, 4-methylbenzyloxycarbonyl group, 2-methylbenzyloxycarbonyl group, 3-methylbenzyloxycarbonyl group, 2,4-dimethylbenzyloxycarbonyl group, 2,3-dimethylbenzyloxycarbonyl group, 2,6-dimethylbenzyloxycarbonyl group, 3,5-dimethylbenzyloxycarbonyl group, 2,5-dimethylbenzyloxycarbonyl group, 2,4,6-trimethylbenzyloxycarbonyl group, 3,5-ditrifluoromethylbenzyl Oki Sicarbonyl group, 4-isopropoxybenzyloxycarbonyl group, 4-n-butoxybenzyloxycarbonyl group, 4-methoxybenzyloxycarbonyl group, 2-methoxybenzyloxycarbonyl group, 3-methoxybenzyloxycarbonyl group, 2,4 -Dimethoxybenzyloxycarbonyl group, 2,3-dimethoxybenzyloxycarbonyl group, 2,6-dimethoxybenzyloxycarbonyl group, 3,5-dimethoxybenzyloxycarbonyl group, 2,5-dimethoxybenzyloxycarbonyl group, 2,4 , 6-trimethoxybenzyloxycarbonyl group, 3,5-ditrifluoromethoxybenzyloxycarbonyl group, 2-isopropoxybenzyloxycarbonyl group, 3-chloro-4-methoxybenzyloxycarbonyl group, 2 Chloro-4-trifluoromethoxybenzyloxycarbonyl group, 3-methyl-4-fluorobenzyloxycarbonyl group, 4-bromo-3-trifluoromethylbenzyloxycarbonyl group, 2- (2-chlorophenyl) ethoxycarbonyl group, 2 -(3-chlorophenyl) ethoxycarbonyl group, 2- (4-chlorophenyl) ethoxycarbonyl group, 2-trifluoromethylbenzyloxycarbonyl group, 3-trifluoromethylbenzyloxycarbonyl group, 4-trifluoromethylbenzyloxycarbonyl group 2-trifluoromethoxybenzyloxycarbonyl group, 3-trifluoromethoxybenzyloxycarbonyl group, 4-trifluoromethoxybenzyloxycarbonyl group, 2- (2-trifluoromethylphenyl) eth Sicarbonyl group, 2- (3-trifluoromethylphenyl) ethoxycarbonyl group, 2- (4-trifluoromethylphenyl) ethoxycarbonyl group, 2- (2-trifluoromethoxyphenyl) ethoxycarbonyl group, 2- (3 -Trifluoromethoxyphenyl) ethoxycarbonyl group, 2- (4-trifluoromethoxyphenyl) ethoxycarbonyl group, 3- (2-trifluoromethylphenyl) propoxycarbonyl group, 3- (3-trifluoromethylphenyl) propoxycarbonyl Group, 3- (4-trifluoromethylphenyl) propoxycarbonyl group, 3- (2-trifluoromethylphenyl) propoxycarbonyl group, 3- (3-trifluoromethoxyphenyl) propoxycarbonyl group, 3- (4-trifluoro Fluoromethoxyph Enyl) propoxycarbonyl group, 4- (3-trifluoromethylphenyl) butoxycarbonyl group, 5- (4-trifluoromethylphenyl) pentoxycarbonyl group, 4- (4-trifluoromethylphenyl) pentoxycarbonyl group, 4- (4-trifluoromethoxyphenyl) pentoxycarbonyl group, 6- (3-trifluoromethylphenyl) hexyloxycarbonyl group, 6- (4-trifluoromethylphenyl) hexyloxycarbonyl group, 6- (4- (Trifluoromethoxyphenyl) hexyloxycarbonyl group and the like.

  As an amino group which may have a group selected from the group consisting of a C1-6 alkanoyl group and a C1-6 alkyl group as a substituent, for example, an amino group, a methylamino group, an ethylamino group, an n-propylamino group , Isopropylamino group, n-butylamino group, tert-butylamino group, n-pentylamino group, n-hexylamino group, dimethylamino group, diethylamino group, di-n-propylamino group, di-n-butylamino Group, di-n-pentylamino group, di-n-hexylamino group, N-methyl-N-ethylamino group, N-ethyl-Nn-propylamino group, N-methyl-Nn-butylamino Group, N-methyl-Nn-hexylamino group, N-methyl-N-acetylamino group, acetylamino group, formylamino group, n-propioni C1-6 alkanoyl groups and C1 as substituents such as amino group, n-butyrylamino group, isobutyrylamino group, n-pentanoylamino group, n-hexanoylamino group, N-ethyl-N-acetylamino group, etc. Mention may be made of amino groups which may have 1 to 2 groups selected from the group consisting of 6 alkyl groups.

  As the 1,2,3,4-tetrahydroquinolyl group (on the 1,2,3,4-tetrahydroquinoline ring, at least one oxo group may be substituted as a substituent), for example, 1 , 2,3,4-tetrahydro-1-quinolyl group, 1,2,3,4-tetrahydro-2-quinolyl group, 1,2,3,4-tetrahydro-3-quinolyl group, 1,2,3, 4-tetrahydro-4-quinolyl group, 1,2,3,4-tetrahydro-5-quinolyl group, 1,2,3,4-tetrahydro-6-quinolyl group, 1,2,3,4-tetrahydro-7 -Quinolyl group, 1,2,3,4-tetrahydro-8-quinolyl group, 2-oxo-1,2,3,4-tetrahydro-1-quinolyl group, 4-oxo-1,2,3,4- Tetrahydro-1-quinolyl group, 2,4-dioxo-1, , 3,4-tetrahydro-1-quinolyl group, 2-oxo-1,2,3,4-tetrahydro-6-quinolyl group, 2-oxo-1,2,3,4-tetrahydro-4-quinolyl group, 2-oxo-1,2,3,4-tetrahydro-7-quinolyl group, 2-oxo-1,2,3,4-tetrahydro-8-quinolyl group, 2-oxo-1,2,3,4- 1,2,3,4-tetrahydroquinolyl group (1,2,3,4-tetrahydroquinoline such as tetrahydro-5-quinolyl group, 2-oxo-1,2,3,4-tetrahydro-3-quinolyl group, etc. On the ring, 1 to 2 oxo groups may be substituted as substituents.

  The C1-6 alkylsulfonyl group is a group composed of an alkyl group composed of 1 to 6 carbon atoms and a sulfonyl group, such as a methanesulfonyl group, an ethanesulfonyl group, an n-propanesulfonyl group, n -A butanesulfonyl group, n-pentanesulfonyl group, n-hexanesulfonyl group, etc. can be mentioned.

  The C3-8 cycloalkyl group is a 3-membered, 4-membered, 5-membered, 6-membered, 7-membered or 8-membered cyclic alkyl group having 3 to 8 carbon atoms. Examples thereof include a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group, a cycloheptyl group, a cyclooctyl group, a 3,4-dimethylcyclopentyl group, and a 3,3-dimethylcyclohexyl group.

  The C1-6 alkylthio group is a linear or branched alkylthio group composed of 1 to 6 carbon atoms, and examples thereof include a methylthio group, an ethylthio group, an n-propylthio group, an isopropylthio group, n -Butylthio group, isobutylthio group, tert-butylthio group, sec-butylthio group, n-pentylthio group, neopentylthio group, n-hexylthio group, isohexylthio group, 3-methylpentylthio group, etc. .

  A phenylsulfonyl group (on the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, a halogen-substituted or unsubstituted C1-6 alkoxy group, and Optionally substituted) is composed of an unsubstituted phenylsulfonyl group, a halogen atom as defined above, a halogen-substituted or unsubstituted C1-6 alkyl group, a halogen-substituted or unsubstituted C1-6 alkoxy group, and the like. A phenylsulfonyl group having 1 to 5, preferably 1 to 3 substituents selected from the group, for example, phenylsulfonyl group, 2-fluorophenylsulfonyl group, 3-fluorophenylsulfonyl group, 4-fluoro Phenylsulfonyl group, 2-chlorophenylsulfonyl group, 3-chlorophenylsulfonyl Group, 4-chlorophenylsulfonyl group, 2-bromophenylsulfonyl group, 3-bromophenylsulfonyl group, 4-bromophenylsulfonyl group, 2-iodophenylsulfonyl group, 3-iodophenylsulfonyl group, 4-iodophenylsulfonyl group, 2,3-difluorophenylsulfonyl group, 3,4-difluorophenylsulfonyl group, 3,5-difluorophenylsulfonyl group, 2,4-difluorophenylsulfonyl group, 2,6-difluorophenylsulfonyl group, 2,3-dichlorophenyl Sulfonyl group, 3,4-dichlorophenylsulfonyl group, 3,5-dichlorophenylsulfonyl group, 2,4-dichlorophenylsulfonyl group, 2,6-dichlorophenylsulfonyl group, 3,4,5-trifluorophenylsulfonyl group, , 4,5-trichlorophenylsulfonyl group, 2,4,6-trifluorophenylsulfonyl group, 2,4,6-trichlorophenylsulfonyl group, 2-fluoro-4-bromophenylsulfonyl group, 4-chloro-3- Fluorophenylsulfonyl group, 2,3,4-trichlorophenylsulfonyl group, 3,4,5-trifluorophenylsulfonyl group, 2,3,4,5,6-pentafluorophenylsulfonyl group, 2,4,6- Trimethylphenylsulfonyl group, 4-n-butylphenylsulfonyl group, 2,4-dimethylphenylsulfonyl group, 2,3-dimethylphenylsulfonyl group, 2,6-dimethylphenylsulfonyl group, 3,5-dimethylphenylsulfonyl group, 2,5-dimethylphenylsulfonyl group, 3,5-ditrifluoromethyl Ruphenylsulfonyl group, 4-n-butoxyphenylsulfonyl group, 2,4-dimethoxyphenylsulfonyl group, 2,3-dimethoxyphenylsulfonyl group, 2,6-dimethoxyphenylsulfonyl group, 3,5-dimethoxyphenylsulfonyl group, 2,5-dimethoxyphenylsulfonyl group, 2,4,6-trimethoxyphenylsulfonyl group, 3,5-ditrifluoromethoxyphenylsulfonyl group, 3-chloro-4-methoxyphenylsulfonyl group, 2-chloro-4-tri Fluoromethoxyphenylsulfonyl group, 3-methyl-4-fluorophenylsulfonyl group, 4-bromo-3-trifluoromethylphenylsulfonyl group, 2-methylphenylsulfonyl group, 3-methylphenylsulfonyl group, 4-methylphenylsulfonyl group , 2- Til-3-chlorophenylsulfonyl group, 3-methyl-4-chlorophenylsulfonyl group, 2-chloro-4-methylphenylsulfonyl group, 2-methyl-3-fluorophenylsulfonyl group, 2-trifluoromethylphenylsulfonyl group, 3 -Trifluoromethylphenylsulfonyl group, 4-trifluoromethylphenylsulfonyl group, 2-pentafluoroethylphenylsulfonyl group, 3-pentafluoroethylphenylsulfonyl group, 4-pentafluoroethylphenylsulfonyl group, 2-isopropylphenylsulfonyl group 3-isopropylphenylsulfonyl group, 4-isopropylphenylsulfonyl group, 2-tert-butylphenylsulfonyl group, 3-tert-butylphenylsulfonyl group, 4-tert-butylphenol Rusulfonyl group, 2-sec-butylphenylsulfonyl group, 3-sec-butylphenylsulfonyl group, 4-sec-butylphenylsulfonyl group, 2-n-heptafluoropropylphenylsulfonyl group, 3-n-heptafluoropropylphenyl Sulfonyl group, 4-n-heptafluoropropylphenylsulfonyl group, 4-n-pentylphenylsulfonyl group, 4-n-hexylphenylsulfonyl group, 2-methoxyphenylsulfonyl group, 3-methoxyphenylsulfonyl group, 4-methoxyphenyl Sulfonyl group, 3-chloro-2-methoxyphenylsulfonyl group, 2-fluoro-3-methoxyphenylsulfonyl group, 2-fluoro-4-methoxyphenylsulfonyl group, 2,6-dimethoxyphenylsulfonyl group, 2,3,4 -G Trifluorophenylsulfonyl group, 2,4,6-trifluorophenylsulfonyl group, 2-trifluoromethoxyphenylsulfonyl group, 3-trifluoromethoxyphenylsulfonyl group, 4-trifluoromethoxyphenylsulfonyl group, 3-fluoro-2 -Trifluoromethoxyphenylsulfonyl group, 2-fluoro-3-trifluoromethoxyphenylsulfonyl group, 3-fluoro-4-trifluoromethoxyphenylsulfonyl group, 3-chloro-2-trifluoromethoxyphenylsulfonyl group, 2-chloro -3-trifluoromethoxyphenylsulfonyl group, 3-chloro-4-trifluoromethoxyphenylsulfonyl group, 2-pentafluoroethoxyphenylsulfonyl group, 3-pentafluoroethoxyphenylsulfonyl group, -Pentafluoroethoxyphenylsulfonyl group, 3-chloro-2-pentafluoroethoxyphenylsulfonyl group, 2-chloro-3-pentafluoroethoxyphenylsulfonyl group, 3-chloro-4-pentafluoroethoxyphenylsulfonyl group, 2-iso Propoxyphenylsulfonyl group, 3-isopropoxyphenylsulfonyl group, 4-isopropoxyphenylsulfonyl group, 2-tert-butoxyphenylsulfonyl group, 3-tert-butoxyphenylsulfonyl group, 4-tert-butoxyphenylsulfonyl group, 2- sec-butoxyphenylsulfonyl group, 3-sec-butoxyphenylsulfonyl group, 4-sec-butoxyphenylsulfonyl group, 2-n-heptafluoropropoxyphenylsulfonyl group, 3-n Heptafluoropropoxy phenylsulfonyl group, 4-n-heptafluoropropoxy phenylsulfonyl group, 4-n-pentoxy phenylsulfonyl group, and a 4-n-hexyloxy phenylsulfonyl group.

  Examples of the amino group-substituted C1-6 alkoxy group that may have a C1-6 alkyl group as a substituent include an aminomethoxy group, 2-aminoethoxy group, 1-aminoethoxy group, 3-aminopropoxy group, 4- Aminobutoxy group, 5-aminopentyloxy group, 6-aminohexyloxy group, 2-methyl-3-aminopropoxy group, 1,1-dimethyl-2-aminoethoxy group, ethylaminomethoxy group, 1- (propylamino) ) Ethoxy group, 2- (methylamino) ethoxy group, 3- (isopropylamino) propoxy group, 4- (n-butylamino) butoxy group, 5- (n-pentylamino) pentyloxy group, 6- (n- (Hexylamino) hexyloxy group, dimethylaminomethoxy group, 3-dimethylaminopropoxy group, (N-ethyl-N Examples of substituents such as propylamino) methoxy group and 2- (N-methyl-N-hexylamino) ethoxy group include amino-C1-6 alkoxy groups which may have 1 to 2 C1-6 alkyl groups. it can.

  Phenyl group [on the phenyl ring, a halogen atom as a substituent, a halogen-substituted or unsubstituted C1-6 alkyl group, a halogen-substituted or unsubstituted C1-6 alkoxy group, a C1-6 alkanoyl group as a substituent, and C1-6 An amino group which may have a group selected from the group consisting of 6 alkyl groups, a C1-6 alkoxycarbonyl group, a phenyl group, a phenoxy group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of an alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), an aminosulfonyl group, 1,2,3,4-tetrahydroquinolyl A group (on the 1,2,3,4-tetrahydroquinoline ring, at least one oxo group may be substituted as a substituent), C1 6 alkylsulfonyl group, C3-8 cycloalkyl group, nitro group, cyano group, C1-6 alkylthio group, phenylsulfonyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen At least one group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted), hydroxyl-substituted C1-6 alkyl groups and groups

(W ₁ represents a C 1-6 alkylene group. R ¹¹ and R ¹² are the same or different and represent a C 1-6 alkoxy group) and at least one group selected from the group consisting of is substituted. May be selected from the above halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups, halogen-substituted or unsubstituted C1-6 alkoxy groups, C1-6 alkanoyl groups and C1-6 alkyl groups as substituents. An amino group having 1 to 2 groups selected from the group consisting of C1-6 alkoxycarbonyl group, phenyl group, phenoxy group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 1-5, preferably 1-3 groups selected from the group consisting of alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups), aminosulfo Group, 1,2,3,4-tetrahydroquinolyl group (on the 1,2,3,4-tetrahydroquinoline ring, 1 to 2 oxo groups may be substituted as a substituent), C1 -6 alkylsulfonyl group, C3-8 cycloalkyl group, nitro group, cyano group, C1-6 alkylthio group, phenylsulfonyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups), hydroxyl-substituted C1-6 alkyl groups and groups

(Wherein W ₁ represents a C 1-6 alkylene group, R ¹¹ and R ¹² are the same or different and represent a C 1-6 alkoxy group), and a group selected from the group consisting of Examples of the phenyl group that may be substituted at the 6-position are 1 to 5, preferably 1 to 3.

  Examples of the hydroxyl group-substituted C1-6 alkyl group include a hydroxymethyl group, a 2-hydroxyethyl group, a 1-hydroxyethyl group, a 3-hydroxypropyl group, a 2,3-dihydroxypropyl group, a 4-hydroxybutyl group, 3, 4-dihydroxybutyl group, 1,1-dimethyl-2-hydroxyethyl group, 5-hydroxypentyl group, 6-hydroxyhexyl group, 2-methyl-3-hydroxypropyl group, 2,3,4-trihydroxybutyl group Examples thereof include C1-6 linear or branched alkyl groups having 1 to 3 hydroxyl groups.

  Examples of the halogen-substituted or unsubstituted C1-10 alkoxy group include, in addition to a halogen-substituted or unsubstituted C1-6 alkoxy group, a heptyloxy group, an octyloxy group, a nonyloxy group, a decyloxy group, and 7-fluoroheptyloxy. Group 7,7,6-trifluoroheptyloxy group, 7,7,7,6,6,5,5-heptafluoroheptyloxy group, 8-chlorooctyloxy group, 8,8-dibromooctyloxy group, 6,7,8-trifluorooctyloxy group, 8,8,8,7,7,6,6-heptafluorooctyloxy group, 8,8,8,7,7-pentachlorooctyloxy group, 9 -Iodononyloxy group, 9,9-dibromononyloxy group, 9,9,9,8,8-pentachlorononyloxy group, 9,9,9,8,8,7,7- Ptafluorononyloxy group, 10-chlorodecyloxy group, 10,10-dibromodecyloxy group, 10,10,10,9-tetrachlorodecyloxy group, 10,10,10,9,9,9,8, Examples thereof include C1-10 alkoxy groups such as 8-heptafluorodecyloxy group and C1-10 alkoxy groups substituted with 1 to 7 halogen atoms.

  A phenyl C1-6 alkyl group (on the phenyl ring, as a substituent, a C1-4 alkylenedioxy group, a phenyl group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1- And at least one group selected from the group consisting of 6 alkoxy groups may be substituted) is an unsubstituted phenyl C1-6 alkyl group and a C1-4 alkyl group on the phenyl ring constituting these groups. 1 to 5 groups, preferably 1 selected from the group consisting of a rangeoxy group, a phenyl group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group -3 substituted groups (if the substituent is a C1-4 alkylenedioxy group, it may be substituted 1-2), Benzyl group, 1-phenethyl group, 2-phenethyl group, 3-phenylpropyl group, 2-phenylpropyl group, 4-phenylbutyl group, 5-phenylpentyl group, 4-phenylpentyl group, 6-phenylhexyl group, 2 , 3-methylenedioxybenzyl group, 3,4-methylenedioxybenzyl group, 3-phenylbenzyl group, 2-phenylbenzyl group, 4-phenylbenzyl group, 3,4-diphenylbenzyl group, 2,4,6 -Triphenylbenzyl group, 2-fluorobenzyl group, 3-fluorobenzyl group, 4-fluorobenzyl group, 2-chlorobenzyl group, 3-chlorobenzyl group, 4-chlorobenzyl group, 2-bromobenzyl group, 3- Bromobenzyl group, 4-bromobenzyl group, 2-iodobenzyl group, 3-iodobenzyl group, 4-iodobenzyl 2,3-difluorobenzyl group, 3,4-difluorobenzyl group, 3,5-difluorobenzyl group, 2,4-difluorobenzyl group, 2,6-difluorobenzyl group, 2,3-dichlorobenzyl group, 3 , 4-dichlorobenzyl group, 3,5-dichlorobenzyl group, 2,4-dichlorobenzyl group, 2,6-dichlorobenzyl group, 2-fluoro-4-bromobenzyl group, 4-chloro-3-fluorobenzyl group 2,3,4-trichlorobenzyl group, 3,4,5-trifluorobenzyl group, 2,4,6-trichlorobenzyl group, 4-ethylbenzyl group, 4-sec-butylbenzyl group, 4-isopropylbenzyl Group, 4-n-butylbenzyl group, 4-methylbenzyl group, 2-methylbenzyl group, 3-methylbenzyl group, 2,4-dimethylbenzyl group 2,3-dimethylbenzyl group, 2,6-dimethylbenzyl group, 3,5-dimethylbenzyl group, 2,5-dimethylbenzyl group, 2,4,6-trimethylbenzyl group, 3,5-ditrifluoromethyl Benzyl group, 2,3,4,5,6-pentafluorobenzyl group, 4-isopropoxybenzyl group, 4-n-butoxybenzyl group, 4-tert-butoxybenzyl group, 4-methoxybenzyl group, 2-methoxy Benzyl group, 3-methoxybenzyl group, 2,4-dimethoxybenzyl group, 2,3-dimethoxybenzyl group, 2,6-dimethoxybenzyl group, 3,5-dimethoxybenzyl group, 2,5-dimethoxybenzyl group, 2 , 4,6-trimethoxybenzyl group, 3,5-ditrifluoromethoxybenzyl group, 2-isopropoxybenzyl group, 3-chloro 4-methoxybenzyl group, 2-chloro-4-trifluoromethoxybenzyl group, 3-methyl-4-fluorobenzyl group, 4-bromo-3-trifluoromethylbenzyl group, 2-trifluoromethylbenzyl group, 3- Trifluoromethylbenzyl group, 4-trifluoromethylbenzyl group, 2-pentafluoroethylbenzyl group, 3-pentafluoroethylbenzyl group, 4-pentafluoroethylbenzyl group, 2-trifluoromethoxybenzyl group, 3-trifluoro Methoxybenzyl group, 4-trifluoromethoxybenzyl group, 2-pentafluoroethoxybenzyl group, 3-pentafluoroethoxybenzyl group, 4-pentafluoroethoxybenzyl group, 2- (2-trifluoromethylphenyl) ethyl group, 2 -(3-trifluoromethyl Nyl) ethyl group, 2- (4-trifluoromethylphenyl) ethyl group, 2- (2-trifluoromethoxyphenyl) ethyl group, 1- (3-trifluoromethoxyphenyl) ethyl group, 2- (4-trimethyl) Fluoromethoxyphenyl) ethyl group, 2- (2-pentafluoroethoxyphenyl) ethyl group, 2- (3-pentafluoroethoxyphenyl) ethyl group, 2- (4-pentafluoroethoxyphenyl) ethyl group, 3- (2 -Trifluoromethylphenyl) propyl group, 3- (3-trifluoromethylphenyl) propyl group, 3- (4-trifluoromethylphenyl) propyl group, 3- (2-trifluoromethoxyphenyl) propyl group, 3- (3-trifluoromethoxyphenyl) propyl group, 3- (4-trifluoromethoxyphenyl) propyl Lopyl group, 3- (3-pentafluoroethoxyphenyl) propyl group, 3- (4-pentafluoroethoxyphenyl) propyl group, 4- (3-pentafluoroethoxyphenyl) butyl group, 5- (4-trifluoromethyl) Phenyl) pentyl group, 4- (4-trifluoromethylphenyl) pentyl group, 4- (4-trifluoromethoxyphenyl) pentyl group, 6- (3-trifluoromethylphenyl) hexyl group, 6- (4-trimethyl) Fluoromethylphenyl) hexyl group, 6- (4-trifluoromethoxyphenyl) hexyl group, 4- (4-chlorophenyl) butyl group and the like can be mentioned.

Phenyl C1-6 alkyl group [on the phenyl ring, a C1-4 alkylenedioxy group as a substituent, a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted group) Or at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted), a group —N (R ^11A ) R ^12A (R ^11A and R ^12A are the same or different. A hydrogen atom, a C1-6 alkyl group or a phenyl group, and R ^11A and R ^12A , together with the adjacent nitrogen atom, are bonded to each other through or without a nitrogen atom, oxygen atom or sulfur atom to form a 5- to 7-membered member. Or a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1). At least one group selected from the group consisting of 6 alkoxy groups may be substituted), a phenyl C1-6 alkoxy group, an amino group-substituted C1-6 that may have a C1-6 alkyl group as a substituent At least one selected from the group consisting of an alkoxy group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-10 alkoxy group may be substituted] For example, a phenyl C1-6 alkyl group (on the phenyl ring, as a substituent, a C1-4 alkylenedioxy group, a phenyl group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group). In addition to 4- (4-tri), at least one group selected from the group consisting of substituted C1-6 alkoxy groups may be substituted. Fluoromethylphenyl) benzyl group, 4- (4-trifluoromethoxyphenyl) benzyl group, 4- (4-chlorophenyl) benzyl group, 4- (4-trifluoromethylphenoxy) benzyl group, 4- (4-trifluoro) Methoxyphenoxy) benzyl group, 4- (4-chlorophenoxy) benzyl group, 4-phenoxybenzyl group, 3-phenoxybenzyl group, 2-phenoxybenzyl group, 2,4-diphenoxybenzyl group, 2,4,6- Triphenoxybenzyl group, 4-benzyloxybenzyl group, 3-benzyloxybenzyl group, 2-benzyloxybenzyl group, 3,4-dibenzyloxybenzyl group, 3,4,5-tribenzyloxybenzyl group, 4- Octyloxybenzyl group, 3-nonyloxybenzyl group, 2-decyloxyben Group, 4-heptyloxybenzyl group, 2,4-dioctyloxybenzyl group, 3,4,6-trioctyloxybenzyl group, 4- (8,8,8-trifluorooctyloxy) benzyl group, 4- Dimethylaminobenzyl group, 4-diphenylaminobenzyl group, 4- (3-dimethylaminopropoxy) benzyl group, 4-di-n-butylaminobenzyl group, 3- (N-methyl-N-ethylamino) benzyl group, 2- (N-methyl-N-phenylamino) benzyl group, 2,4,6-methylaminobenzyl group, 3- (3-dimethylaminopropoxy) benzyl group, 2,4-di-n-butylaminobenzyl group 4- (2-methylaminoethoxy) benzyl group, 2- (4-methylaminobutoxy) benzyl group, 4- (2-dimethylaminoethoxy) benzyl group Zyl group, 2,3-diethylaminomethoxybenzyl group, 2,4,6-tri (2-dimethylaminoethoxy) benzyl group, 2-phenoxy-3-phenylbenzyl group, 4-octyloxy-3-trifluoromethoxybenzyl A phenyl C1-6 alkyl group such as 4-benzyloxy-2-dimethylaminobenzyl, 4- (1-pyrrolidinyl) benzyl group, 4- (1-piperidyl) benzyl group [on the phenyl ring, C1-4 alkylenedioxy group, phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted linear or branched alkyl group having 1 to 6 carbon atoms, a halogen-substituted or unsubstituted carbon 1 to 5 groups, preferably 1 to 3 groups selected from the group consisting of linear or branched alkoxy groups having 1 to 6 numbers may be substituted) , Group -N (R ^<11A> ) R ^<12A> (R ^<11A> and R ^<12A> are the same or different and each represents a hydrogen atom, a C1-6 alkyl group or a phenyl group. R ^11A and R ^12A , together with an adjacent nitrogen atom, may be bonded to each other via or without a nitrogen atom, oxygen atom or sulfur atom to form a 5- to 7-membered saturated heterocyclic ring), a phenoxy group ( On the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted straight chain or branched alkyl group having 1 to 6 carbon atoms, a halogen-substituted or unsubstituted straight chain or branched chain having 1 to 6 carbon atoms. 1 to 5, preferably 1 to 3 groups selected from the group consisting of chain alkoxy groups), a phenyl C1-6 alkoxy group, and a C1-6 alkyl group as a substituent. 1 to 5 groups selected from the group consisting of an amino group-substituted C1-6 alkoxy group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-10 alkoxy group , Mashiku may have one to three substitutions. In the case where the substituent is a C1-4 alkylenedioxy group, it may be substituted 1-2).

  A benzofuryl C1-6 alkyl group [on the benzofuran ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; The species may be substituted, for example, (2-, 3-, 4-, 5-, 6- or 7-) benzofurylmethyl group, 1- (2-benzofuryl) ethyl group, 2- (3-benzofuryl) ethyl group, 3- (4-benzofuryl) propyl group, 2- (5-benzofuryl) propyl group, 2- (6-benzofuryl) propyl group, 4- (7-benzofuryl) butyl group, 5- (2-benzofuryl) pentyl group, 4- (3-benzofuryl) pentyl group, 6- (4-benzofuryl) hexyl group, 2-methyl-3- (5-benzofuryl) propyl group, , 1-dimethyl-2- (6-benzofuryl) ethyl group, (5-chloro-2-benzofuryl) methyl group, 2- (5-trifluoromethoxybenzofuryl) methyl group, 2- (5-trifluoromethylbenzoate) Furyl) methyl, (6-trifluoromethylbenzofuryl) methyl, 2- (5-methylbenzofuryl) methyl, 2- (5-methoxybenzofuryl) methyl, (5,6-dibromo-2- Benzofuryl) methyl group, (3,5,6-trifluoro-2-benzofuryl) methyl group, 2- (5,6-dimethylbenzofuryl) methyl group, 2- (5,7-dimethoxybenzofuryl) methyl group, 2- (5,6,7-trimethylbenzofuryl) methyl group, 2- (3,5,6-trimethoxybenzofuryl) methyl group, 2- (5-trifluoromethyl-6) Benzofuryl C1-6 alkyl group such as chlorobenzofuryl) methyl group, 2- (5-trifluoromethoxy-6-methoxybenzofuryl) methyl group [on the benzofuran ring, halogen atom, halogen-substituted or unsubstituted C1- 1 to 3 groups selected from the group consisting of 6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted.

  Phenylsulfonyl group [on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, a halogen-substituted or unsubstituted C1-6 alkoxy group, and a C1-4 alkylenedioxy group. And at least one of the groups may be substituted] means an unsubstituted phenylsulfonyl group, a halogen atom as defined above, a halogen-substituted or unsubstituted C1-6 alkyl group, a halogen-substituted or unsubstituted C1 A phenylsulfonyl group having 1 to 5, preferably 1 to 3 substituents selected from the group consisting of -6 alkoxy groups and C1-4 alkylenedioxy groups (when the substituent is a C1-4 alkylenedioxy group) May be substituted by 1 to 2), for example, phenylsulfonyl group, 2-fluorophenylsulfonyl 3-fluorophenylsulfonyl group, 4-fluorophenylsulfonyl group, 2-chlorophenylsulfonyl group, 3-chlorophenylsulfonyl group, 4-chlorophenylsulfonyl group, 2-bromophenylsulfonyl group, 3-bromophenylsulfonyl group, 4-bromo Phenylsulfonyl group, 2-iodophenylsulfonyl group, 3-iodophenylsulfonyl group, 4-iodophenylsulfonyl group, 2,3-difluorophenylsulfonyl group, 3,4-difluorophenylsulfonyl group, 3,5-difluorophenylsulfonyl Group, 2,4-difluorophenylsulfonyl group, 2,6-difluorophenylsulfonyl group, 2,3-dichlorophenylsulfonyl group, 3,4-dichlorophenylsulfonyl group, 3,5-dichlorophenylsulfo group Group, 2,4-dichlorophenylsulfonyl group, 2,6-dichlorophenylsulfonyl group, 3,4,5-trifluorophenylsulfonyl group, 3,4,5-trichlorophenylsulfonyl group, 2,4,6-trifluoro Phenylsulfonyl group, 2,4,6-trichlorophenylsulfonyl group, 2-fluoro-4-bromophenylsulfonyl group, 4-chloro-3-fluorophenylsulfonyl group, 2,3,4-trichlorophenylsulfonyl group, 3, 4,5-trifluorophenylsulfonyl group, 2,3,4,5,6-pentafluorophenylsulfonyl group, 2,4,6-trimethylphenylsulfonyl group, 4-n-butylphenylsulfonyl group, 2,4- Dimethylphenylsulfonyl group, 2,3-dimethylphenylsulfonyl group, 2,6-di Methylphenylsulfonyl group, 3,5-dimethylphenylsulfonyl group, 2,5-dimethylphenylsulfonyl group, 3,5-ditrifluoromethylphenylsulfonyl group, 4-n-butoxyphenylsulfonyl group, 2,4-dimethoxyphenylsulfonyl Group, 2,3-dimethoxyphenylsulfonyl group, 2,6-dimethoxyphenylsulfonyl group, 3,5-dimethoxyphenylsulfonyl group, 2,5-dimethoxyphenylsulfonyl group, 2,4,6-trimethoxyphenylsulfonyl group, 3,5-ditrifluoromethoxyphenylsulfonyl group, 3-chloro-4-methoxyphenylsulfonyl group, 2-chloro-4-trifluoromethoxyphenylsulfonyl group, 3-methyl-4-fluorophenylsulfonyl group, 4-bromo- 3-Trifluo Methylphenylsulfonyl group, 2-methylphenylsulfonyl group, 3-methylphenylsulfonyl group, 4-methylphenylsulfonyl group, 2-methyl-3-chlorophenylsulfonyl group, 3-methyl-4-chlorophenylsulfonyl group, 2-chloro- 4-methylphenylsulfonyl group, 2-methyl-3-fluorophenylsulfonyl group, 2-trifluoromethylphenylsulfonyl group, 3-trifluoromethylphenylsulfonyl group, 4-trifluoromethylphenylsulfonyl group, 2-pentafluoroethyl Phenylsulfonyl group, 3-pentafluoroethylphenylsulfonyl group, 4-pentafluoroethylphenylsulfonyl group, 2-isopropylphenylsulfonyl group, 3-isopropylphenylsulfonyl group, 4-isopropyl Enylsulfonyl group, 2-tert-butylphenylsulfonyl group, 3-tert-butylphenylsulfonyl group, 4-tert-butylphenylsulfonyl group, 2-sec-butylphenylsulfonyl group, 3-sec-butylphenylsulfonyl group, 4 -Sec-butylphenylsulfonyl group, 2-n-heptafluoropropylphenylsulfonyl group, 3-n-heptafluoropropylphenylsulfonyl group, 4-n-heptafluoropropylphenylsulfonyl group, 4-n-pentylphenylsulfonyl group, 4-n-hexylphenylsulfonyl group, 2-methoxyphenylsulfonyl group, 3-methoxyphenylsulfonyl group, 4-methoxyphenylsulfonyl group, 3-chloro-2-methoxyphenylsulfonyl group, 2-fluoro-3-methyl Toxiphenylsulfonyl group, 2-fluoro-4-methoxyphenylsulfonyl group, 2,6-dimethoxyphenylsulfonyl group, 2,3,4-trifluorophenylsulfonyl group, 2,4,6-trifluorophenylsulfonyl group, 2 -Trifluoromethoxyphenylsulfonyl group, 3-trifluoromethoxyphenylsulfonyl group, 4-trifluoromethoxyphenylsulfonyl group, 3-fluoro-2-trifluoromethoxyphenylsulfonyl group, 2-fluoro-3-trifluoromethoxyphenylsulfonyl Group, 3-fluoro-4-trifluoromethoxyphenylsulfonyl group, 3-chloro-2-trifluoromethoxyphenylsulfonyl group, 2-chloro-3-trifluoromethoxyphenylsulfonyl group, 3-chloro-4-trifluoro Romethoxyphenylsulfonyl group, 2-pentafluoroethoxyphenylsulfonyl group, 3-pentafluoroethoxyphenylsulfonyl group, 4-pentafluoroethoxyphenylsulfonyl group, 3-chloro-2-pentafluoroethoxyphenylsulfonyl group, 2-chloro- 3-pentafluoroethoxyphenylsulfonyl group, 3-chloro-4-pentafluoroethoxyphenylsulfonyl group, 2-isopropoxyphenylsulfonyl group, 3-isopropoxyphenylsulfonyl group, 4-isopropoxyphenylsulfonyl group, 2-tert- Butoxyphenylsulfonyl group, 3-tert-butoxyphenylsulfonyl group, 4-tert-butoxyphenylsulfonyl group, 2-sec-butoxyphenylsulfonyl group, 3-sec-butyl Xiphenylsulfonyl group, 4-sec-butoxyphenylsulfonyl group, 2-n-heptafluoropropoxyphenylsulfonyl group, 3-n-heptafluoropropoxyphenylsulfonyl group, 4-n-heptafluoropropoxyphenylsulfonyl group, 4-n -Pentoxyphenylsulfonyl group, 4-n-hexyloxyphenylsulfonyl group, 2,3-methylenedioxyphenylsulfonyl group, 3,4-methylenedioxyphenylsulfonyl group and the like can be mentioned.

  Phenoxycarbonyl group [on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. May be, for example, phenoxycarbonyl group, 2-fluorophenoxycarbonyl group, 3-fluorophenoxycarbonyl group, 2,3,4,5,6-pentafluorophenoxycarbonyl group, 4-fluorophenoxycarbonyl group 2-chlorophenoxycarbonyl group, 3-chlorophenoxycarbonyl group, 4-chlorophenoxycarbonyl group, 2,3-dichlorophenoxycarbonyl group, 3,4-dichlorophenoxycarbonyl group, 3,5-dichlorophenoxycarbonyl group, 2 -Bromophenoxycal Nyl group, 3-bromophenoxycarbonyl group, 4-bromophenoxycarbonyl group, 2-methylphenoxycarbonyl group, 3-methylphenoxycarbonyl group, 4-methylphenoxycarbonyl group, 2-ethylphenoxycarbonyl group, 3-ethylciphenoxy Carbonyl group, 4-ethylphenoxycarbonyl group, 4-n-propylphenoxycarbonyl group, 4-tert-butylphenoxycarbonyl group, 4-n-butylphenoxycarbonyl group, 2,3-dimethylphenoxycarbonyl group, 3,4, 5-trimethylphenoxycarbonyl group, 4-n-pentylphenoxycarbonyl group, 4-n-hexylphenoxycarbonyl group, 2-fluoro-4-bromophenoxycarbonyl group, 4-chloro-3-fluorophenoxycarbonyl group 2,3,4-trichlorophenoxycarbonyl group, 2,4,6-trichlorophenoxycarbonyl group, 4-isopropylphenoxycarbonyl group, 4-n-butylphenoxycarbonyl group, 2,4-dimethylphenoxycarbonyl group, 2 , 3-dimethylphenoxycarbonyl group, 2,6-dimethylphenoxycarbonyl group, 3,5-dimethylphenoxycarbonyl group, 2,5-dimethylphenoxycarbonyl group, 2,4,6-trimethylphenoxycarbonyl group, 3,5- Ditrifluoromethylphenoxycarbonyl group, 4-n-butoxyphenoxycarbonyl group, 2,4-dimethoxyphenoxycarbonyl group, 2,3-dimethoxyphenoxycarbonyl group, 2,6-dimethoxyphenoxycarbonyl group, 3,5-dimethoxyphenoxyca Rubonyl group, 2,5-dimethoxyphenoxycarbonyl group, 3,5-ditrifluoromethoxyphenoxycarbonyl group, 3-chloro-4-methoxyphenoxycarbonyl group, 2-chloro-4-trifluoromethoxyphenoxycarbonyl group, 3-methyl -4-fluorophenoxycarbonyl group, 4-bromo-3-trifluoromethylphenoxycarbonyl group, 2-trifluoromethylphenoxycarbonyl group, 3-trifluoromethylphenoxycarbonyl group, 4-trifluoromethylphenoxycarbonyl group, 2- Pentafluoroethylphenoxycarbonyl group, 3-pentafluoroethylciphenoxycarbonyl group, 4-pentafluoroethylphenoxycarbonyl group, 2-methoxyphenoxycarbonyl group, 3-methoxyphenoxyca Bonyl group, 4-methoxyphenoxycarbonyl group, 2-ethoxyphenoxycarbonyl group, 3-ethoxyphenoxycarbonyl group, 4-ethoxyphenoxycarbonyl group, 4-n-propoxyphenoxycarbonyl group, 4-tert-butoxyphenoxycarbonyl group, 4 -N-butoxyphenoxycarbonyl group, 2,3-dimethoxyphenoxycarbonyl group, 3,4,5-trimethoxyphenoxycarbonyl group, 4-n-pentoxyphenoxycarbonyl group, 4-n-hexyloxyphenoxycarbonyl group, 2 -Trifluoromethoxyphenoxycarbonyl group, 3-trifluoromethoxyphenoxycarbonyl group, 4-trifluoromethoxyphenoxycarbonyl group, 2-pentafluoroethoxyphenoxycarbonyl group, 3-penta Phenoxycarbonyl groups such as uroethoxyphenoxycarbonyl group and 4-pentafluoroethoxyphenoxycarbonyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 1 to 5 groups, preferably 1 to 3 groups selected from the group consisting of alkoxy groups may be substituted).

  The C1-6 alkoxy-substituted C1-6 alkyl group is a group composed of the above C1-6 alkyl group and a C1-6 alkoxy group, for example, a methoxymethyl group, a 2-methoxyethyl group, a 3-methoxypropyl group. Group, 4-methoxybutyl group, 5-methoxypentyl group, 6-methoxyhexyl group, ethoxymethyl group, 2-ethoxyethyl group, 3-ethoxypropyl group, 2-isopropoxyethyl group, tert-butoxymethyl group, pentyl An oxymethyl group, a hexyloxymethyl group, a 2- (tert-butoxy) ethyl group, a 3- (tert-butoxy) propyl group, a 6- (tert-butoxy) hexyl group, a 4- (tert-butoxy) butyl group, etc. Can be mentioned.

  Examples of the C2-6 alkenyl group include a vinyl group, 2-propenyl group, 3-butenyl group, 2-butenyl group, 4-pentenyl group, 3-pentenyl group, 5-hexenyl group, 4-hexenyl group, 3-hexenyl group etc. can be mentioned.

  The C1-6 alkoxy-substituted C2-6 alkanoyl group is a group composed of the C1-6 alkyl group and the C2-6 alkanoyl group, and includes, for example, a 2-methoxyacetyl group, a 2-methoxypropionyl group, a 3- Methoxypropionyl group, 4-methoxybutyryl group, 5-methoxypentanoyl group, 6-methoxyhexanoyl group, 2-ethoxyacetyl group, 2-ethoxypropionyl group, 3-ethoxypropionyl group, 2-isopropoxypropionyl group, 2- (tert-butoxy) acetyl group, 2-pentyloxyacetyl group, 2-hexyloxyacetyl group, 2- (tert-butoxy) propionyl group, 3- (tert-butoxy) propionyl group, 6- (tert-butoxy) ) Hexanoyl group, 4- (tert-butoxy) butyryl group, etc. It can gel.

  The C3-8 cycloalkyl-substituted C1-6 alkyl group is a group composed of a cyclic alkyl group having 3 to 8 carbon atoms and an alkyl group having 1 to 6 carbon atoms, such as a cyclopropylmethyl group, 2-cyclopropylethyl group, 3-cyclopropylpropyl group, 4-cyclopropylbutyl group, 5-cyclopropylpentyl group, 6-cyclopropylhexyl group, cyclobutylmethyl group, 2-cyclobutylethyl group, 3-cyclo Butylpropyl, 4-cyclobutylbutyl, 5-cyclobutylpentyl, 6-cyclobutylhexyl, cyclopentylmethyl, 2-cyclopentylethyl, 3-cyclopentylpropyl, 4-cyclopentylbutyl, 5-cyclopentyl Pentyl group, 6-cyclopentylhexyl group, cyclohexylmethyl group, -Cyclohexylethyl group, 3-cyclohexylpropyl group, 4-cyclohexylbutyl group, 5-cyclohexylpentyl group, 6-cyclohexylhexyl group, cycloheptylmethyl group, 2-cycloheptylethyl group, 3-cycloheptylpropyl group, 4- Cycloheptylbutyl group, 5-cycloheptylpentyl group, 6-cycloheptylhexyl group, cyclooctylmethyl group, 2-cyclooctylethyl group, 3-cyclooctylpropyl group, 4-cyclooctylbutyl group, 5-cyclooctylpentyl Group, 6-cyclooctylhexyl group and the like.

  Examples of the pyridyl C1-6 alkyl group include a 2-pyridylmethyl group, 2- (3-pyridyl) ethyl group, 1- (4-pyridyl) ethyl group, 3- (2-pyridyl) propyl group, 4- ( 3-pyridyl) butyl group, 5- (4-pyridyl) pentyl group, 6- (2-pyridyl) hexyl group, 2-methyl-3- (3-pyridyl) propyl group, 1,1-dimethyl-2- ( 2-pyridyl) ethyl and the like.

  Examples of the imidazolyl C1-6 alkyl group (which may be substituted with a phenyl group on the imidazole ring) include 4-imidazolylmethyl group, 2- (4-imidazolyl) ethyl group, and 3- (2-imidazolyl). ) Propyl group, 4- (1-imidazolyl) butyl group, 5- (5-imidazolyl) pentyl group, 6- (4-imidazolyl) hexyl group, 2,5-diphenyl-1-imidazolylmethyl group, 2-phenyl- 4-imidazolylmethyl group, 2- (2-phenyl-4-imidazolyl) ethyl group, 3- (2-phenyl-4-imidazolyl) propyl group, 4- (2-phenyl-5-imidazolyl) butyl group, 5- Imidazolyl C1-6 alkyl such as (2-phenyl-4-imidazolyl) pentyl group and 6- (2-phenyl-4-imidazolyl) hexyl group (On the imidazole ring, a phenyl group may be one to two substituents) group and the like.

  1,2,3,4-tetrahydroquinolyl group (on the 1,2,3,4-tetrahydroquinoline ring, at least one group selected from the group consisting of oxo group and C1-6 alkyl group as a substituent) Examples of the optionally substituted species include 1,2,3,4-tetrahydro-1-quinolyl group, 1,2,3,4-tetrahydro-2-quinolyl group, 1,2,3, 4-tetrahydro-3-quinolyl group, 1,2,3,4-tetrahydro-4-quinolyl group, 1,2,3,4-tetrahydro-5-quinolyl group, 1,2,3,4-tetrahydro-6 -Quinolyl group, 1,2,3,4-tetrahydro-7-quinolyl group, 1,2,3,4-tetrahydro-8-quinolyl group, 2-oxo-1,2,3,4-tetrahydro-1- Quinolyl group, 4-oxo-1,2,3,4-teto Hydro-1-quinolyl group, 2,4-dioxo-1,2,3,4-tetrahydro-1-quinolyl group, 2-oxo-1,2,3,4-tetrahydro-6-quinolyl group, 2-oxo -1,2,3,4-tetrahydro-4-quinolyl group, 2-oxo-1,2,3,4-tetrahydro-7-quinolyl group, 2-oxo-1,2,3,4-tetrahydro-8 -Quinolyl group, 2-oxo-1,2,3,4-tetrahydro-5-quinolyl group, 2-oxo-1,2,3,4-tetrahydro-3-quinolyl group, 2-methyl-1,2, 3,4-tetrahydro-1-quinolyl group, 4-ethyl-1,2,3,4-tetrahydro-1-quinolyl group, 2,4-dimethyl-1,2,3,4-tetrahydro-1-quinolyl group 1,5,6-trimethyl-1,2,3,4-tetrahi B-1-quinolyl group, 1,4,5,6-tetramethyl-2-oxo-1,2,3,4-tetrahydro-1-quinolyl group, 1-propyl-1,2,3,4-tetrahydro -6-quinolyl group, 5-n-pentyl-1,2,3,4-tetrahydro-4-quinolyl group, 6-n-hexyl-1,2,3,4-tetrahydro-7-quinolyl group, 7- tert-butyl-1,2,3,4-tetrahydro-8-quinolyl group, 8-n-pentyl-1,2,3,4-tetrahydro-8-quinolyl group, 1-n-hexyl-2-oxo- 1,2,3,4-tetrahydro-8-quinolyl group, 1-methyl-2-oxo-1,2,3,4-tetrahydro-5-quinolyl group, 3-ethyl-2-oxo-1,2, 1,2,3,4-teto such as 3,4-tetrahydro-3-quinolyl group A lahydroquinolyl group (on the 1,2,3,4-tetrahydroquinoline ring, 1 to 5 groups selected from the group consisting of an oxo group and a C1-6 alkyl group may be substituted as substituents); Can be mentioned.

  Examples of the amino group that may have a C1-6 alkyl group as a substituent include an amino group, a methylamino group, an ethylamino group, an n-propylamino group, an isopropylamino group, an n-butylamino group, and a tert-butylamino monomer. Group, n-pentylamino group, n-hexylamino group, dimethylamino group, diethylamino group, di-n-propylamino group, di-n-butylamino group, di-n-pentylamino group, di-n-hexyl Amino groups, N-methyl-N-ethylamino groups, N-ethyl-Nn-propylamino groups, N-methyl-Nn-butylamino groups, N-methyl-Nn-hexylamino groups, etc. Examples of the substituent include amino groups having 1 to 2 C1-6 alkyl groups.

  Examples of the cyano-substituted C1-6 alkyl group include a cyanomethyl group, 2-cyanoethyl group, 1-cyanoethyl group, 3-cyanopropyl group, 4-cyanobutyl group, 5-cyanopentyl group, 6-cyanohexyl group, 2- Examples thereof include a methyl-3-cyanopropyl group and a 1,1-dimethyl-2-cyanoethyl group.

  Examples of the furyl-substituted C1-6 alkyl group include 2-furylmethyl group, 3-furylmethyl group, 2- (2-furyl) ethyl group, 1- (3-furyl) ethyl group, 3- (2-furyl). ) Propyl, 3- (3-furyl) propyl, 4- (2-furyl) butyl, 4- (3-furyl) butyl, 5- (2-furyl) pentyl, 5- (3-furyl) ) Pentyl group, 6- (2-furyl) hexyl group, 6- (3-furyl) hexyl group and the like.

  Piperazinyl-substituted C1-6 alkyl group [on piperazine ring, at least one phenyl group as a substituent (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted The group may be substituted with at least one group selected from the group consisting of C1-6 alkoxy groups of the above], for example, 1-piperazinylmethyl group, 2- ( 2-piperazinyl) ethyl group, 1- (1-piperazinyl) ethyl group, 3- (1-piperazinyl) propyl group, 4- (1-piperazinyl) butyl group, 5- (2-piperazinyl) pentyl group, 6- ( 1-piperazinyl) hexyl group, 2- (4-phenyl-1-piperazinyl) ethyl group, 3- (4-phenyl-1-piperazinyl) propyl group, 4- (4-phenyl) Nyl-1-piperazinyl) butyl group, 5- (4-phenyl-1-piperazinyl) pentyl group, 6- (4-phenyl-1-piperazinyl) hexyl group, 2- [4- (2-fluorophenyl) -1 -Piperazinyl] ethyl group, 3- [4- (2-fluorophenyl) -1-piperazinyl] propyl group, 4- [4- (2,3-difluorophenyl) -1-piperazinyl] butyl group, 5- [4 -(2-fluorophenyl) -1-piperazinyl] pentyl group, 6- [4- (4-fluorophenyl) -1-piperazinyl] hexyl group, 3- [4- (3-fluorophenyl) -1-piperazinyl] Propyl group, 4- [4- (3-fluorophenyl) -1-piperazinyl] butyl group, 5- [4- (3-fluorophenyl) -1-piperazinyl] pentyl group, 3- 4- (4-fluorophenyl) -1-piperazinyl] propyl group, 4- [4- (4-fluorophenyl) -1-piperazinyl] butyl group, 5- [4- (4-fluorophenyl) -1-piperazinyl ] Pentyl group, 6- [4- (4-fluorophenyl) -1-piperazinyl] hexyl group, 2- [4- (2,3-dichlorophenyl) -1-piperazinyl] ethyl group, 3- [4- (2 -Chlorophenyl) -1-piperazinyl] propyl group, 4- [4- (2-chlorophenyl) -1-piperazinyl] butyl group, 5- [4- (2,4,6-trichlorophenyl) -1-piperazinyl] pentyl Group, 6- [4- (2-chlorophenyl) -1-piperazinyl] hexyl group, 2- [4- (3-chlorophenyl) -1-piperazinyl] ethyl group, 3- [4- ( -Chlorophenyl) -1-piperazinyl] propyl group, 4- [4- (3-chlorophenyl) -1-piperazinyl] butyl group, 5- [4- (2,3,4,5,6-pentafluorophenyl)- 1-piperazinyl] pentyl group, 6- [4- (3-chloro-4-methylphenyl) -1-piperazinyl] hexyl group, 2- [4- (4-chlorophenyl) -1-piperazinyl] ethyl group, 3- [4- (4-Chlorophenyl) -1-piperazinyl] propyl group, 4- [4- (4-Chloro-3-methoxyphenyl) -1-piperazinyl] butyl group, 5- [4- (4-chlorophenyl)- 1-piperazinyl] pentyl group, 6- [4- (4-chlorophenyl) -1-piperazinyl] hexyl group, 2- [4- (2-methylphenyl) -1-piperazinyl] methyl group 2- [4- (2,4-dimethylphenyl) -1-piperazinyl] methyl group, 2- [4- (2,4,6-trimethylphenyl) -1-piperazinyl] methyl group, 2- [4- (2-trifluoromethylphenyl) -1-piperazinyl] ethyl group, 3- [4- (3,5-ditrifluoromethylphenyl) -1-piperazinyl] propyl group, 4- [4- (2-trifluoromethyl) Phenyl) -1-piperazinyl] butyl group, 5- [4- (2-trifluoromethylphenyl) -1-piperazinyl] pentyl group, 6- [4- (2-trifluoromethylphenyl) -1-piperazinyl] hexyl Group, 3- [4- (3-trifluoromethylphenyl) -1-piperazinyl] propyl group, 4- [4- (3-trifluoromethylphenyl) -1-piperazinyl] Til group, 5- [4- (3-trifluoromethylphenyl) -1-piperazinyl] pentyl group, 3- [4- (4-trifluoromethylphenyl) -1-piperazinyl] propyl group, 4- [4- (4-trifluoromethylphenyl) -1-piperazinyl] butyl group, 5- [4- (4-trifluoromethylphenyl) -1-piperazinyl] pentyl group, 6- [4- (4-trifluoromethylphenyl) -1-piperazinyl] hexyl group, 2- [4- (3,5-ditrifluoromethoxyphenyl) -1-piperazinyl] ethyl group, 2- [4- (2-methoxyphenyl) -1-piperazinyl] methyl group, 2- [4- (2,4-dimethoxyphenyl) -1-piperazinyl] methyl group, 2- [4- (2,4,6-trimethoxyphenyl) -1-piperazini ] Methyl group, 3- [4- (2-trifluoromethoxyphenyl) -1-piperazinyl] propyl group, 4- [4- (2-trifluoromethoxyphenyl) -1-piperazinyl] butyl group, 5- [4 -(2-trifluoromethoxyphenyl) -1-piperazinyl] pentyl group, 6- [4- (2-trifluoromethoxyphenyl) -1-piperazinyl] hexyl group, 3- [4- (3-trifluoromethoxyphenyl) ) -1-piperazinyl] propyl group, 4- [4- (3-trifluoromethoxyphenyl) -1-piperazinyl] butyl group, 5- [4- (3-trifluoromethoxyphenyl) -1-piperazinyl] pentyl group 3- [4- (4-trifluoromethoxyphenyl) -1-piperazinyl] propyl group, 4- [4- (4-trifluoromethoxy) Ciphenyl) -1-piperazinyl] butyl group, 5- [4- (4-trifluoromethoxyphenyl) -1-piperazinyl] pentyl group, 6- [4- (4-trifluoromethoxyphenyl) -1-piperazinyl] hexyl A piperazinyl-substituted C1-6 alkyl group such as a group, 2,4-diphenyl-1-piperazinylmethyl group, (2,4,5-triphenyl-1-piperazinyl) methyl group [on the piperazine ring, 1 to 3 phenyl groups as substituents (on the phenyl ring, selected from the group consisting of halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups) 1 to 5 groups, preferably 1 to 3 groups, which may be substituted) may be substituted.

A 5- to 7-membered member formed by R ⁹ and R ¹⁰ , R ^11A and R ^12A or R ^11B and R ^12B being bonded to each other with or without a nitrogen atom, oxygen atom or sulfur atom together with an adjacent nitrogen atom Examples of the saturated heterocyclic group include pyrrolidinyl group, piperazyl group, piperidyl group, morpholino group, thiomorpholino group, and homopiperazinyl group.

A 1,2,3,4-tetrahydroisoquinolyl group, an isoindolyl group formed by R ⁹ and R ¹⁰ , together with an adjacent nitrogen atom, bonded or not via a nitrogen atom, an oxygen atom or a sulfur atom, or On a 5- to 7-membered saturated heterocyclic ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, a halogen-substituted or unsubstituted C1-6 alkoxy group, a phenyl group [on the phenyl ring, A phenyl group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted], Benzoyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one group selected from the group described above may be substituted], pyridyl C1-6 alkyl group, C3-8 cycloalkyl group, phenyl C1-6 alkyl group [on the phenyl ring, C1-4 At least one selected from the group consisting of an alkylenedioxy group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. ], Piperidyl C1-6 alkyl group, piperidyl group, phenyl C1-6 alkoxy group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy At least one group selected from the group consisting of groups may be substituted], a phenoxy group [on the phenyl ring, a halogen atom, halogen-substituted Or at least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted], a phenyl group [phenyl ring as a substituent Above, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. A C1-6 alkyl group and a phenyl C1-6 alkyl group [on the phenyl ring, from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] At least one selected group may be substituted] at least one group selected from the group consisting of: an amino group, a benzoxazolyl A phenyl C2-6 alkenyl group (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) And at least one group selected from the group consisting of benzimidazolyl groups may be substituted. Examples of such substituents include halogen atoms exemplified above and below. A halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group, a phenyl group [on the phenyl ring, a phenyl group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl 1 to 5, preferably 1 to 3 groups selected from the group consisting of a group and a halogen-substituted or unsubstituted C1-6 alkoxy group Or a benzoyl group [on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, a halogen-substituted or unsubstituted C1-6 alkoxy group is 1 -5, preferably 1 to 3 may be substituted], pyridyl C1-6 alkyl group, C3-8 cycloalkyl group, phenyl C1-6 alkyl group [on the phenyl ring, C1-4 alkylenediene] 1 to 5 groups selected from the group consisting of an oxy group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group, preferably 1-3 You may do it. When the substituent is a C1-4 alkylenedioxy group, it may be substituted by 1 to 2], piperidyl C1-6 alkyl group, piperidyl group, phenyl C1-6 alkoxy group [on the phenyl ring, a halogen atom 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. ], A phenoxy group [on the phenyl ring, 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group , Preferably 1 to 3 may be substituted], phenyl group as a substituent [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or 1 to 5, preferably 1 to 3 groups selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted], C1-6 alkyl groups and phenyl C1-6 alkyl groups [phenyl] On the ring, there are 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. 1 to 2 groups selected from the group consisting of an optionally substituted amino group, a benzoxazolyl group, a phenyl C2-6 alkenyl group (on the phenyl ring, a halogen atom) A group consisting of an atom, a halogen-substituted or unsubstituted straight-chain or branched alkyl group having 1 to 6 carbon atoms, and a halogen-substituted or unsubstituted straight-chain or branched alkoxy group having 1 to 6 carbon atoms 1 to 5 groups selected more Preferably 1 to 3 substituents and may be) and a group selected from the group consisting of benzimidazolyl group may be one to three substituents.

On the 5- to 7-membered saturated heterocyclic ring formed by combining R ^11B and R ^12B together with adjacent nitrogen atoms through or without a nitrogen atom, oxygen atom or sulfur atom, C 1-6 An alkoxycarbonyl group and an amino group [on the amino group, a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] At least one group selected from the group may be substituted) and at least one group selected from the group consisting of C1-6 alkyl groups may be substituted]. At least one of the above groups may be substituted, and examples of such a substituent include C1-6 alkoxycarbonyl groups and amino groups exemplified above and below. Nyl group (on the phenyl ring, preferably 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group, May be substituted by 1 to 3 groups) and a group selected from the group consisting of C1-6 alkyl groups may be substituted by 1 to 2 groups], and groups selected from the group consisting of One to three of these substituents may be substituted on the heterocyclic ring.

  Phenyl group [on the phenyl ring, at least one group selected from the group consisting of a phenyl group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; May be substituted] means an unsubstituted phenyl group and a phenyl group as defined above, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy. A phenyl group having 1 to 5, preferably 1 to 3 substituents selected from the group consisting of phenyl group, 2-phenylphenyl group, 3-phenylphenyl group, 4-phenylphenyl group, 2,3-diphenylphenyl, 2,4,6-triphenylphenyl group, 2-fluorophenyl group, 3-fluoropheny Group, 4-fluorophenyl group, 2-chlorophenyl group, 3-chlorophenyl group, 4-chlorophenyl group, 2-bromophenyl group, 3-bromophenyl group, 4-bromophenyl group, 2-iodophenyl group, 3-iodo Phenyl group, 4-iodophenyl group, 2,3-difluorophenyl group, 3,4-difluorophenyl group, 3,5-difluorophenyl group, 2,4-difluorophenyl group, 2,6-difluorophenyl group, 2 , 3-dichlorophenyl group, 3,4-dichlorophenyl group, 3,5-dichlorophenyl group, 2,4-dichlorophenyl group, 2,6-dichlorophenyl group, 3,4,5-trifluorophenyl group, 3,4,5 -Trichlorophenyl group, 2,4,6-trifluorophenyl group, 2,4,6-trichlorophenyl group, 2-fur Rho-4-bromophenyl group, 4-chloro-3-fluorophenyl group, 2,3,4-trichlorophenyl group, 3,4,5-trifluorophenyl group, 2,3,4,5,6-penta Fluorophenyl group, 2,4,6-trimethylphenyl group, 4-n-butylphenyl group, 2,4-dimethylphenyl group, 2,3-dimethylphenyl group, 2,6-dimethylphenyl group, 3,5- Dimethylphenyl group, 2,5-dimethylphenyl group, 3,5-ditrifluoromethylphenyl group, 4-n-butoxyphenyl group, 2,4-dimethoxyphenyl group, 2,3-dimethoxyphenyl group, 2,6- Dimethoxyphenyl group, 3,5-dimethoxyphenyl group, 2,5-dimethoxyphenyl group, 2,4,6-trimethoxyphenyl group, 3,5-ditrifluoromethoxyphenyl Nyl group, 3-chloro-4-methoxyphenyl group, 2-chloro-4-trifluoromethoxyphenyl group, 3-methyl-4-fluorophenyl group, 4-bromo-3-trifluoromethylphenyl group, 2-methyl Phenyl group, 3-methylphenyl group, 4-methylphenyl group, 2-methyl-3-chlorophenyl group, 3-methyl-4-chlorophenyl group, 2-chloro-4-methylphenyl group, 2-methyl-3-fluoro Phenyl group, 2-trifluoromethylphenyl group, 3-trifluoromethylphenyl group, 4-trifluoromethylphenyl group, 2-pentafluoroethylphenyl group, 3-pentafluoroethylphenyl group, 4-pentafluoroethylphenyl group 2-isopropylphenyl group, 3-isopropylphenyl group, 4-isopropylphenyl Group, 2-tert-butylphenyl group, 3-tert-butylphenyl group, 4-tert-butylphenyl group, 2-sec-butylphenyl group, 3-sec-butylphenyl group, 4-sec-butylphenyl group, 2-n-heptafluoropropylphenyl group, 3-n-heptafluoropropylphenyl group, 4-n-heptafluoropropylphenyl group, 4-n-pentylphenyl group, 4-n-hexylphenyl group, 2-methoxyphenyl Group, 3-methoxyphenyl group, 4-methoxyphenyl group, 3-chloro-2-methoxyphenyl group, 2-fluoro-3-methoxyphenyl group, 2-fluoro-4-methoxyphenyl group, 2,6-dimethoxyphenyl Group, 2,3,4-trifluorophenyl group, 2,4,6-trifluorophenyl group, 2-to Fluoromethoxyphenyl group, 3-trifluoromethoxyphenyl group, 4-trifluoromethoxyphenyl group, 3-fluoro-2-trifluoromethoxyphenyl group, 2-fluoro-3-trifluoromethoxyphenyl group, 3-fluoro-4 -Trifluoromethoxyphenyl group, 3-chloro-2-trifluoromethoxyphenyl group, 2-chloro-3-trifluoromethoxyphenyl group, 3-chloro-4-trifluoromethoxyphenyl group, 2-pentafluoroethoxyphenyl group 3-pentafluoroethoxyphenyl group, 4-pentafluoroethoxyphenyl group, 3-chloro-2-pentafluoroethoxyphenyl group, 2-chloro-3-pentafluoroethoxyphenyl group, 3-chloro-4-pentafluoroethoxy Phenyl group, 2-iso Propoxyphenyl group, 3-isopropoxyphenyl group, 4-isopropoxyphenyl group, 2-tert-butoxyphenyl group, 3-tert-butoxyphenyl group, 4-tert-butoxyphenyl group, 2-sec-butoxyphenyl group, 3-sec-butoxyphenyl group, 4-sec-butoxyphenyl group, 2-n-heptafluoropropoxyphenyl group, 3-n-heptafluoropropoxyphenyl group, 4-n-heptafluoropropoxyphenyl group, 4-n- Examples thereof include a pentoxyphenyl group and a 4-n-hexyloxyphenyl group.

  Phenyl C1-6 alkoxy group [on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; The species may be substituted] means a group selected from the group consisting of the above-defined halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group, and halogen-substituted or unsubstituted C1-6 alkoxy group Is a phenyl C1-6 alkoxy group optionally substituted by 1 to 5, preferably benzyloxy group, 2-phenylethoxy group, 3-phenylpropoxy group, 2-phenylpropoxy group, for example. Group, 4-phenylbutoxy group, 5-phenylpentoxy group, 4-phenylpentoxy group, 6-phenylhexyloxy 2-fluorobenzyloxy group, 3-fluorobenzyloxy group, 4-fluorobenzyloxy group, 2- (2-fluorophenyl) ethoxy group, 2- (3-fluorophenyl) ethoxy group, 2- (4-fluoro Phenyl) ethoxy group, 2-chlorobenzyloxy group, 3-chlorobenzyloxy group, 4-chlorobenzyloxy group, 2-fluoro-4-bromobenzyloxy group, 4-chloro-3-fluorobenzyloxy group, 2- Chloro-4-fluorobenzyloxy group, 3,4-dichlorobenzyloxy group, 3,5-dichlorobenzyloxy group, 2,3-dichlorobenzyloxy group, 2,5-dichlorobenzyloxy group, 2,3,4 -Trichlorobenzyloxy group, 3,4,5-trifluorobenzyloxy group, 2,3,4,5,6-pen Fluorobenzyloxy group, 2,4,6-trichlorobenzyloxy group, 4-isopropylbenzyloxy group, 4-n-butylbenzyloxy group, 4-methylbenzyloxy group, 2-methylbenzyloxy group, 3-methylbenzyl Oxy group, 2,4-dimethylbenzyloxy group, 2,3-dimethylbenzyloxy group, 2,6-dimethylbenzyloxy group, 3,5-dimethylbenzyloxy group, 2,5-dimethylbenzyloxy group, 2, 4,6-trimethylbenzyloxy group, 4-ethylbenzyloxy group, 4-isopropylbenzyloxy group, 3,5-ditrifluoromethylbenzyloxy group, 4-isopropoxybenzyloxy group, 4-n-butoxybenzyloxy group 4-methoxybenzyloxy group, 2-methoxybenzyloxy group, 3 -Methoxybenzyloxy group, 2,4-dimethoxybenzyloxy group, 2,3-dimethoxybenzyloxy group, 2,6-dimethoxybenzyloxy group, 3,5-dimethoxybenzyloxy group, 2,5-dimethoxybenzyloxy group 2,4,6-trimethoxybenzyloxy group, 3,5-ditrifluoromethoxybenzyloxy group, 2-isopropoxybenzyloxy group, 3-chloro-4-methoxybenzyloxy group, 2-chloro-4-tri Fluoromethoxybenzyloxy group, 3-methyl-4-fluorobenzyloxy group, 4-bromo-3-trifluoromethylbenzyloxy group, 2- (2-chlorophenyl) ethoxy group, 2- (3-chlorophenyl) ethoxy group, 2- (4-Chlorophenyl) ethoxy group, 2-trifluoromethylbenzyl Oxy group, 3-trifluoromethylbenzyloxy group, 4-trifluoromethylbenzyloxy group, 2-trifluoromethoxybenzyloxy group, 3-trifluoromethoxybenzyloxy group, 4-trifluoromethoxybenzyloxy group, 2- (2-trifluoromethylphenyl) ethoxy group, 2- (3-trifluoromethylphenyl) ethoxy group, 2- (4-trifluoromethylphenyl) ethoxy group, 2- (2-trifluoromethoxyphenyl) ethoxy group, 2- (3-trifluoromethoxyphenyl) ethoxy group, 2- (4-trifluoromethoxyphenyl) ethoxy group, 3- (2-trifluoromethylphenyl) propoxy group, 3- (3-trifluoromethylphenyl) propoxy Group, 3- (4-trifluoromethylphenyl) Roxy group, 3- (2-trifluoromethylphenyl) propoxy group, 3- (3-trifluoromethoxyphenyl) propoxy group, 3- (4-trifluoromethoxyphenyl) propoxy group, 4- (3-trifluoromethyl) Phenyl) butoxy group, 5- (4-trifluoromethylphenyl) pentoxy group, 4- (4-trifluoromethylphenyl) pentoxy group, 4- (4-trifluoromethoxyphenyl) pentoxy group, 6- (3-tri Examples thereof include a fluoromethylphenyl) hexyloxy group, a 6- (4-trifluoromethylphenyl) hexyloxy group, and a 6- (4-trifluoromethoxyphenyl) hexyloxy group.

  Phenoxy group [On the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. May be selected from the group consisting of an unsubstituted phenoxy group and a halogen atom as defined above, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. A phenoxy group having 1 to 5, preferably 1 to 3 substituents, such as phenoxy group, 2-fluorophenoxy group, 3-fluorophenoxy group, 4-fluorophenoxy group, 2-chlorophenoxy group 3-chlorophenoxy group, 4-chlorophenoxy group, 2-bromophenoxy group, 3-bromophenoxy group Group, 4-bromophenoxy group, 2-iodophenoxy group, 3-iodophenoxy group, 4-iodophenoxy group, 2,3-difluorophenoxy group, 3,4-difluorophenoxy group, 3,5-difluorophenoxy group, 2,4-difluorophenoxy group, 2,6-difluorophenoxy group, 2,3-dichlorophenoxy group, 3,4-dichlorophenoxy group, 3,5-dichlorophenoxy group, 2,4-dichlorophenoxy group, 2, 6-dichlorophenoxy group, 3,4,5-trifluorophenoxy group, 3,4,5-trichlorophenoxy group, 2,4,6-trifluorophenoxy group, 2,4,6-trichlorophenoxy group, 2- Fluoro-4-bromophenoxy group, 4-chloro-3-fluorophenoxy group, 2,3,4-trichlorophenoxy group Group, 3,4,5-trifluorophenoxy group, 2,3,4,5,6-pentafluorophenoxy group, 2,4,6-trimethylphenoxy group, 4-n-butylphenoxy group, 2,4- Dimethylphenoxy group, 2,3-dimethylphenoxy group, 2,6-dimethylphenoxy group, 3,5-dimethylphenoxy group, 2,5-dimethylphenoxy group, 3,5-ditrifluoromethylphenoxy group, 4-n- Butoxyphenoxy group, 2,4-dimethoxyphenoxy group, 2,3-dimethoxyphenoxy group, 2,6-dimethoxyphenoxy group, 3,5-dimethoxyphenoxy group, 2,5-dimethoxyphenoxy group, 2,4,6- Trimethoxyphenoxy group, 3,5-ditrifluoromethoxyphenoxy group, 3-chloro-4-methoxyphenoxy group, 2-chloro -4-trifluoromethoxyphenoxy group, 3-methyl-4-fluorophenoxy group, 4-bromo-3-trifluoromethylphenoxy group, 2-methylphenoxy group, 3-methylphenoxy group, 4-methylphenoxy group, 2 -Methyl-3-chlorophenoxy group, 3-methyl-4-chlorophenoxy group, 2-chloro-4-methylphenoxy group, 2-methyl-3-fluorophenoxy group, 2-trifluoromethylphenoxy group, 3-tri Fluoromethylphenoxy group, 4-trifluoromethylphenoxy group, 2-pentafluoroethylphenoxy group, 3-pentafluoroethylphenoxy group, 4-pentafluoroethylphenoxy group, 2-isopropylphenoxy group, 3-isopropylphenoxy group, 4 -Isopropylphenoxy group, 2-ter -Butylphenoxy group, 3-tert-butylphenoxy group, 4-tert-butylphenoxy group, 2-sec-butylphenoxy group, 3-sec-butylphenoxy group, 4-sec-butylphenoxy group, 2-n-hepta Fluoropropylphenoxy group, 3-n-heptafluoropropylphenoxy group, 4-n-heptafluoropropylphenoxy group, 4-n-pentylphenoxy group, 4-n-hexylphenoxy group, 2-methoxyphenoxy group, 3-methoxy Phenoxy group, 4-methoxyphenoxy group, 3-chloro-2-methoxyphenoxy group, 2-fluoro-3-methoxyphenoxy group, 2-fluoro-4-methoxyphenoxy group, 2,6-dimethoxyphenoxy group, 2,3 , 4-trifluorophenoxy group, 2,4,6-trifluoro Lophenoxy group, 2-trifluoromethoxyphenoxy group, 3-trifluoromethoxyphenoxy group, 4-trifluoromethoxyphenoxy group, 3-fluoro-2-trifluoromethoxyphenoxy group, 2-fluoro-3-trifluoromethoxyphenoxy group Group, 3-fluoro-4-trifluoromethoxyphenoxy group, 3-chloro-2-trifluoromethoxyphenoxy group, 2-chloro-3-trifluoromethoxyphenoxy group, 3-chloro-4-trifluoromethoxyphenoxy group, 2-pentafluoroethoxyphenoxy group, 3-pentafluoroethoxyphenoxy group, 4-pentafluoroethoxyphenoxy group, 3-chloro-2-pentafluoroethoxyphenoxy group, 2-chloro-3-pentafluoroethoxyphenoxy group, 3- The Rollo-4-pentafluoroethoxyphenoxy group, 2-isopropoxyphenoxy group, 3-isopropoxyphenoxy group, 4-isopropoxyphenoxy group, 2-tert-butoxyphenoxy group, 3-tert-butoxyphenoxy group, 4-tert -Butoxyphenoxy group, 2-sec-butoxyphenoxy group, 3-sec-butoxyphenoxy group, 4-sec-butoxyphenoxy group, 2-n-heptafluoropropoxyphenoxy group, 3-n-heptafluoropropoxyphenoxy group, 4 -N-heptafluoropropoxyphenoxy group, 4-n-pentoxyphenoxy group, 4-n-hexyloxyphenoxy group and the like can be mentioned.

  Phenyl C1-6 alkyl group [on the phenyl ring, a group consisting of a C1-4 alkylenedioxy group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group] And at least one kind selected from the group may be substituted] means an unsubstituted phenyl C1-6 alkyl group and a C1-4 alkylenedioxy group or a halogen atom on the phenyl ring constituting the group. A group substituted with 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group ( In the case where the substituent is a C1-4 alkylenedioxy group, it may be substituted by 1 to 2), for example, a benzyl group, a 1-phenethyl group, a 2-phenyl group Netyl group, 3-phenylpropyl group, 2-phenylpropyl group, 4-phenylbutyl group, 5-phenylpentyl group, 4-phenylpentyl group, 6-phenylhexyl group, 2,3-methylenedioxybenzyl group, 3 , 4-methylenedioxybenzyl group, 2-fluorobenzyl group, 3-fluorobenzyl group, 4-fluorobenzyl group, 2-chlorobenzyl group, 3-chlorobenzyl group, 4-chlorobenzyl group, 2-bromobenzyl group 3-bromobenzyl group, 4-bromobenzyl group, 2-iodobenzyl group, 3-iodobenzyl group, 4-iodobenzyl group, 2,3-difluorobenzyl group, 3,4-difluorobenzyl group, 3,5 -Difluorobenzyl group, 2,4-difluorobenzyl group, 2,6-difluorobenzyl group, 2,3-dichloroben Group, 3,4-dichlorobenzyl group, 3,5-dichlorobenzyl group, 2,4-dichlorobenzyl group, 2,6-dichlorobenzyl group, 2-fluoro-4-bromobenzyl group, 4-chloro-3 -Fluorobenzyl group, 2,3,4-trichlorobenzyl group, 3,4,5-trifluorobenzyl group, 2,4,6-trichlorobenzyl group, 4-isopropylbenzyl group, 4-n-butylbenzyl group, 4-methylbenzyl group, 2-methylbenzyl group, 3-methylbenzyl group, 2,4-dimethylbenzyl group, 2,3-dimethylbenzyl group, 2,6-dimethylbenzyl group, 3,5-dimethylbenzyl group, 2,5-dimethylbenzyl group, 2,4,6-trimethylbenzyl group, 3,5-ditrifluoromethylbenzyl group, 2,3,4,5,6-pentafluoroben Gyl group, 4-isopropoxybenzyl group, 4-n-butoxybenzyl group, 4-methoxybenzyl group, 2-methoxybenzyl group, 3-methoxybenzyl group, 2,4-dimethoxybenzyl group, 2,3-dimethoxybenzyl Group, 2,6-dimethoxybenzyl group, 3,5-dimethoxybenzyl group, 2,5-dimethoxybenzyl group, 2,4,6-trimethoxybenzyl group, 3,5-ditrifluoromethoxybenzyl group, 2-iso Propoxybenzyl group, 3-chloro-4-methoxybenzyl group, 2-chloro-4-trifluoromethoxybenzyl group, 3-methyl-4-fluorobenzyl group, 4-bromo-3-trifluoromethylbenzyl group, 2- Trifluoromethylbenzyl group, 3-trifluoromethylbenzyl group, 4-trifluoromethylbenzyl group, 2 Pentafluoroethylbenzyl group, 3-pentafluoroethylbenzyl group, 4-pentafluoroethylbenzyl group, 2-trifluoromethoxybenzyl group, 3-trifluoromethoxybenzyl group, 4-trifluoromethoxybenzyl group, 2-pentafluoro Ethoxybenzyl group, 3-pentafluoroethoxybenzyl group, 4-pentafluoroethoxybenzyl group, 2- (2-trifluoromethylphenyl) ethyl group, 2- (3-trifluoromethylphenyl) ethyl group, 2- (4 -Trifluoromethylphenyl) ethyl group, 2- (2-trifluoromethoxyphenyl) ethyl group, 3-trifluoromethoxyphenyl) ethyl group, 2- (4-trifluoromethoxyphenyl) ethyl group, 2- (2- Pentafluoroethoxyphenyl) ethyl group 2- (3-pentafluoroethoxyphenyl) ethyl group, 2- (4-pentafluoroethoxyphenyl) ethyl group, 3- (2-trifluoromethylphenyl) propyl group, 3- (3-trifluoromethylphenyl) propyl Group, 3- (4-trifluoromethylphenyl) propyl group, 3- (2-trifluoromethoxyphenyl) propyl group, 3- (3-trifluoromethoxyphenyl) propyl group, 3- (4-trifluoromethoxyphenyl) ) Propyl group, 3- (3-pentafluoroethoxyphenyl) propyl group, 3- (4-pentafluoroethoxyphenyl) propyl group, 4- (3-pentafluoroethoxyphenyl) butyl group, 5- (4-trifluoro) Methylphenyl) pentyl group, 4- (4-trifluoromethylphenyl) pentyl Group, 4- (4-trifluoromethoxyphenyl) pentyl group, 6- (3-trifluoromethylphenyl) hexyl group, 6- (4-trifluoromethylphenyl) hexyl group, 6- (4-trifluoromethoxyphenyl) ) Hexyl group and the like.

  Examples of piperidyl C1-6 alkyl groups include piperidin-1-ylmethyl group, piperidin-2-ylethyl group, piperidin-3-ylpropyl group, piperidin-4-ylbutyl group, piperidin-1-ylpentyl group, and piperidine-2. -An ylhexyl group etc. can be mentioned.

  A phenyl group as a substituent [on the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; May be substituted], a C1-6 alkyl group and a phenyl C1-6 alkyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1 As an amino group that may be substituted with at least one group selected from the group consisting of a group selected from the group consisting of ˜6 alkoxy groups may be substituted, for example, Amino group, methylamino group, dimethylamino group, ethylamino group, diethylamino group, n-propylamino group, n-butylamino group, n-pentylami Group, n-hexylamino group, phenylamino group, (4-chlorophenyl) amino group, (4-bromophenyl) amino group, (2,4-dichlorophenyl) amino group, (2,4,6-trichlorophenyl) amino Group, (2,3,4,5,6-pentafluorophenyl) amino group, (4-fluorophenyl) amino group, (4-iodophenyl) amino group, (4-chlorophenyl) amino group, (3-methyl (Phenyl) amino group, (2-trifluoromethylphenyl) amino group, (3-trifluoromethylphenyl) amino group, (4-trifluoromethylphenyl) amino group, (3,4-dimethylphenyl) amino group, ( 3,4,5-trimethylphenyl) amino group, (2-methoxyphenyl) amino group, (4-trifluoromethoxyphenyl) amino Group, (3-trifluoromethoxyphenyl) amino group, (3,5-dimethoxyphenyl) amino group, (2,5-dimethoxyphenyl) amino group, (2,4,6-trimethoxyphenyl) amino group, N -Methyl-N- (4-trifluoromethylphenyl) amino group, N-ethyl-N- (4-trifluoromethoxyphenyl) amino group, 1-phenethylamino group, 2-phenethylamino group, 3-phenylpropylamino Group, 2-phenylpropylamino group, 4-phenylbutylamino group, 5-phenylpentylamino group, 4-phenylpentylamino group, 6-phenylhexylamino group, 2-fluorobenzylamino group, 3-fluorobenzylamino group N-phenyl-N- (4-fluorobenzyl) amino group, 2-chlorobenzylamino group, 3 -Chlorobenzylamino group, 4-chlorobenzylamino group, 2-bromobenzylamino group, N-methyl-N- (3-bromobenzyl) amino group, 4-bromobenzylamino group, 2-iodobenzylamino group, 3 -Iodobenzylamino group, 4-iodobenzylamino group, 2,3-difluorobenzylamino group, 3,4-difluorobenzylamino group, 3,5-difluorobenzylamino group, 2,4-difluorobenzylamino group, 2 , 6-Difluorobenzylamino group, 2,3-dichlorobenzylamino group, 3,4-dichlorobenzylamino group, 3,5-dichlorobenzylamino group, 2,4-dichlorobenzylamino group, 2,6-dichlorobenzyl Amino group, 2-fluoro-4-bromobenzylamino group, 4-chloro-3-fluorobenzyl Mino group, 2,3,4-trichlorobenzylamino group, 3,4,5-trifluorobenzylamino group, 2,4,6-trichlorobenzylamino group, 4-isopropylbenzylamino group, 4-n-butylbenzyl Amino group, 4-methylbenzylamino group, 2-methylbenzylamino group, 3-methylbenzylamino group, 2,4-dimethylbenzylamino group, 2,3-dimethylbenzylamino group, 2,6-dimethylbenzylamino group 3,5-dimethylbenzylamino group, 2,5-dimethylbenzylamino group, 2,4,6-trimethylbenzylamino group, 3,5-ditrifluoromethylbenzylamino group, 2,3,4,5,6 -Pentafluorobenzylamino group, 4-isopropoxybenzylamino group, 4-n-butoxybenzylamino group, 4-methyl Xoxybenzylamino group, 2-methoxybenzylamino group, 3-methoxybenzylamino group, 2,4-dimethoxybenzylamino group, 2,3-dimethoxybenzyl group, 2,6-dimethoxybenzylamino group, 3,5-dimethoxy Benzylamino group, 2,5-dimethoxybenzylamino group, 2,4,6-trimethoxybenzylamino group, 3,5-ditrifluoromethoxybenzylamino group, 2-isopropoxybenzylamino group, 3-chloro-4- Methoxybenzylamino group, 2-chloro-4-trifluoromethoxybenzylamino group, 3-methyl-4-fluorobenzylamino group, 4-bromo-3-trifluoromethylbenzylamino group, 2-trifluoromethylbenzylamino group , 3-trifluoromethylbenzylamino group, 4-trifluoro Romethylbenzylamino group, 2-pentafluoroethylbenzylamino group, 3-pentafluoroethylbenzylamino group, 4-pentafluoroethylbenzylamino group, 2-trifluoromethoxybenzylamino group, 3-trifluoromethoxybenzylamino group 4-trifluoromethoxybenzylamino group, 2-pentafluoroethoxybenzylamino group, 3-pentafluoroethoxybenzylamino group, 4-pentafluoroethoxybenzylamino group, 2- (2-trifluoromethylphenyl) ethylamino group 2- (3-trifluoromethylphenyl) ethylamino group, 2- (4-trifluoromethylphenyl) ethylamino group, 2- (2-trifluoromethoxyphenyl) ethylamino group, 2- (3-trifluoro Methoxyphenyl Ethylamino group, 2- (4-trifluoromethoxyphenyl) ethylamino group, 2- (2-pentafluoroethoxyphenyl) ethylamino group, 2- (3-pentafluoroethoxyphenyl) ethylamino group, 2- (4 -Pentafluoroethoxyphenyl) ethylamino group, 3- (2-trifluoromethylphenyl) propylamino group, 3- (3-trifluoromethylphenyl) propylamino group, 3- (4-trifluoromethylphenyl) propylamino group Group, 3- (2-trifluoromethoxyphenyl) propylamino group, 3- (3-trifluoromethoxyphenyl) propylamino group, 3- (4-trifluoromethoxyphenyl) propylamino group, 3- (3-penta Fluoroethoxyphenyl) propylamino group, 3- (4-penta Fluoroethoxyphenyl) propylamino group, 4- (3-pentafluoroethoxyphenyl) butylamino group, 5- (4-trifluoromethylphenyl) pentylamino group, 4- (4-trifluoromethylphenyl) pentylamino group 4- (4-trifluoromethoxyphenyl) pentylamino group, 6- (3-trifluoromethylphenyl) hexylamino group, 6- (4-trifluoromethylphenyl) hexylamino group, 6- (4-trifluoro Methoxyphenyl) hexylamino group, N-methyl-N-phenylamino group, N-methyl-N-benzylamino group, N-phenyl-N-benzylamino group, etc. Halogen atom, halogen substituted or unsubstituted C1-6 alkyl group and halogen substituted or unsubstituted 1 to 5, preferably 1 to 3 groups selected from the group consisting of substituted C1-6 alkoxy groups may be substituted], a C1-6 alkyl group and a phenyl C1-6 alkyl group [phenyl ring. Above, 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group Examples thereof include an amino group which may be substituted by 1 to 2 groups selected from the group consisting of [which may be substituted].

  Phenyl C1-6 alkyl group (on the phenyl ring, halogen atom, phenyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy) Selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. Examples of the above-mentioned phenyl C1-6 alkyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen) In addition to 4- or 4- (4-toe), at least one group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted. Fluoromethylphenyl) benzyl group, 4- (4-trifluoromethoxyphenyl) benzyl group, 4- (4-chlorophenyl) benzyl group, 4- (4-trifluoromethylphenyl) benzyl group, 4-phenylbenzyl group, 3 Alkyl such as -phenylbenzyl group, 3,4-diphenylbenzyl group, 3,4,5-triphenylbenzyl group, 4-nitro-3-trifluoromethylbenzyl group, 4-trifluoromethoxy-3-phenylbenzyl group A phenylalkyl group whose moiety is a linear or branched alkyl group having 1 to 6 carbon atoms (on the phenyl ring, a halogen atom, a phenyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted); 1 to 5 groups selected from the group consisting of C1-6 alkyl groups, halogen-substituted or unsubstituted C1-6 alkoxy groups Preferably 1 to 3 substituents), 1 to 5 group groups selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups Or preferably 1 to 3 may be substituted).

  A carbamoyloxy group (on the amino group, a C1-6 alkyl group and a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy; At least one group selected from the group consisting of a group selected from the group consisting of groups may be substituted], for example, a carbamoyloxy group, Phenylcarbamoyloxy group, 2-fluorophenylcarbamoyloxy group, 3-fluorophenylcarbamoyloxy group, 4-fluorophenylcarbamoyloxy group, 2-chlorophenylcarbamoyloxy group, 3-chlorophenylcarbamoyloxy group, 4-chlorophenylcarbamoyloxy group, 2-Bromophenylcarbamoyl Si group, 3-bromophenylcarbamoyloxy group, 4-bromophenylcarbamoyloxy group, 2-iodophenylcarbamoyloxy group, 3-iodophenylcarbamoyloxy group, 4-iodophenylcarbamoyloxy group, 2,3-difluorophenylcarbamoyl Oxy group, 3,4-difluorophenylcarbamoyloxy group, 3,5-difluorophenylcarbamoyloxy group, 2,4-difluorophenylcarbamoyloxy group, 2,6-difluorophenylcarbamoyloxy group, 2,3-dichlorophenylcarbamoyloxy group Group, 3,4-dichlorophenylcarbamoyloxy group, 3,5-dichlorophenylcarbamoyloxy group, 2,4-dichlorophenylcarbamoyloxy group, 2,6-dichlorophenylcarbamoyl Oxy group, 3,4,5-trifluorophenylcarbamoyloxy group, 2,3,4,5,6-pentafluorophenylcarbamoyloxy group, 3,4,5-trichlorophenylcarbamoyloxy group, 2,4,6 -Trifluorophenylcarbamoyloxy group, 2,4,6-trichlorophenylcarbamoyloxy group, 2-methylphenylcarbamoyloxy group, 3-methylphenylcarbamoyloxy group, 4-methylphenylcarbamoyloxy group, 2-methyl-3- Chlorophenylcarbamoyloxy group, 3-methyl-4-chlorophenylcarbamoyloxy group, 2-chloro-4-methylphenylcarbamoyloxy group, 2-methyl-3-fluorophenylcarbamoyloxy group, 2-trifluoromethylphenylcarbamoyloxy group 3-trifluoromethylphenylcarbamoyloxy group, methylcarbamoyloxy group, ethylcarbamoyloxy group, n-propylcarbamoyloxy group, n-butylcarbamoyloxy group, n-hexylcarbamoyloxy group, n-pentylcarbamoyloxy group, N -Methyl-N-phenylcarbamoyloxy group, N, N-dimethylcarbamoyloxy group, N-methyl-N-ethylcarbamoyloxy group, N- (2-fluorophenyl) -N-methylcarbamoyloxy group, N- (3 -Fluorophenyl) -N-methylcarbamoyloxy group, N- (4-fluorophenyl) -N-methylcarbamoyloxy group, N- (2-chlorophenyl) -N-methylcarbamoyloxy group, N- (3-chlorophenyl) -N-methylcarbamoy Oxy group, N- (4-chlorophenyl) -N-methylcarbamoyloxy group, N- (4-bromophenyl) -N-methylcarbamoyloxy group, N- (2-iodophenyl) -N-methylcarbamoyloxy group, N- (3-iodophenyl) -N-methylcarbamoyloxy group, N- (4-iodophenyl) -N-methylcarbamoyloxy group, N- (2,3-difluorophenyl) -N-methylcarbamoyloxy group, N- (3,4-difluorophenyl) -N-methylcarbamoyloxy group, N- (3,5-difluorophenyl) -N-methylcarbamoyloxy group, N- (2,4-difluorophenyl) -N-methyl Carbamoyloxy group, N- (2,6-difluorophenyl) -N-methylcarbamoyloxy group, N- (2,3- Chlorophenyl) -N-methylcarbamoyloxy group, N- (3,4-dichlorophenyl) -N-methylcarbamoyloxy group, N- (3,5-dichlorophenyl) -N-methylcarbamoyloxy group, N- (2,4 -Dichlorophenyl) -N-methylcarbamoyloxy group, N- (2,6-dichlorophenyl) -N-methylcarbamoyloxy group, N- (3,4,5-trifluorophenyl) -N-methylcarbamoyloxy group, N -(3,4,5-trichlorophenyl) -N-methylcarbamoyloxy group, N- (2,4,6-trifluorophenyl) -N-methylcarbamoyloxy group, N- (2,4,6-tri Chlorophenyl) -N-methylcarbamoyloxy group, N- (2-methylphenyl) -N-methylcarbamoyloxy group, N- (3-methylphenyl) -N-methylcarbamoyloxy group, N- (4-methylphenyl) -N-methylcarbamoyloxy group, N- (2-methyl-3-chlorophenyl) -N-methylcarbamoyloxy group N- (3-methyl-4-chlorophenyl) -N-methylcarbamoyloxy group, N- (2-chloro-4-methylphenyl) -N-methylcarbamoyloxy group, N- (2-methyl-3-fluoro) Phenyl) -N-methylcarbamoyloxy group, N- (2-trifluoromethylphenyl) -N-methylcarbamoyloxy group, N- (4-trifluoromethylphenyl) -N-methylcarbamoyloxy group, N-phenyl- N-phenylcarbamoyloxy group, N-phenyl-N- (2-fluorophenyl) carbamoyloxy group, -Phenyl-N- (3-fluorophenyl) carbamoyloxy group, N-phenyl-N- (4-fluorophenyl) carbamoyloxy group, N-phenyl-N- (2-chlorophenyl) carbamoyloxy group, N-phenyl- N- (3-chlorophenyl) carbamoyloxy group, N-phenyl-N- (4-chlorophenyl) carbamoyloxy group, N-phenyl-N- (2-bromophenyl) carbamoyloxy group, N-phenyl-N- (3 -Bromophenyl) carbamoyloxy group, N-phenyl-N- (4-bromophenyl) carbamoyloxy group, N-phenyl-N- (2-iodophenyl) carbamoyloxy group, N-phenyl-N- (3-iodo Phenyl) carbamoyloxy group, N-phenyl-N- (4-iodophenyl) carbonyl Vamoyloxy group, N-phenyl-N- (2,3-difluorophenyl) carbamoyloxy group, N-phenyl-N- (3,4-difluorophenyl) carbamoyloxy group, N-phenyl-N- (3,5- Difluorophenyl) carbamoyloxy group, N-phenyl-N- (2,4-difluorophenyl) carbamoyloxy group, N-phenyl-N- (2,6-difluorophenyl) carbamoyloxy group, N-phenyl-N- ( 2,3-dichlorophenyl) carbamoyloxy group, N-phenyl-N- (3,4-dichlorophenyl) carbamoyloxy group, N-phenyl-N- (3,5-dichlorophenyl) carbamoyloxy group, N-phenyl-N- (2,4-dichlorophenyl) carbamoyloxy group, N-phenyl-N- (2,6 -Dichlorophenyl) carbamoyloxy group, N-phenyl-N- (3,4,5-trifluorophenyl) carbamoyloxy group, N-phenyl-N- (3,4,5-trichlorophenyl) carbamoyloxy group, N- Phenyl-N- (2,4,6-trifluorophenyl) carbamoyloxy group, N-phenyl-N- (2,4,6-trichlorophenyl) carbamoyloxy group, N-phenyl-N- (2-methylphenyl) ) Carbamoyloxy group, N-phenyl-N- (3-methylphenyl) carbamoyloxy group, N-phenyl-N- (4-methylphenyl) carbamoyloxy group, N-phenyl-N- (2-methyl-3-) Chlorophenyl) carbamoyloxy group, N-phenyl-N- (3-methyl-4-chlorophenyl) carbamoyl Xy group, N-phenyl-N- (2-chloro-4-methylphenyl) carbamoyloxy group, N-phenyl-N- (2-methyl-3-fluorophenyl) carbamoyloxy group, N-phenyl-N- ( 2-trifluoromethylphenyl) carbamoyloxy group, N-phenyl-N- (3-trifluoromethylphenyl) carbamoyloxy group, N-phenyl-N- (4-trifluoromethylphenyl) carbamoyloxy group, 2-penta Fluoroethylphenylcarbamoyloxy group, 3-pentafluoroethylphenylcarbamoyloxy group, 4-pentafluoroethylphenylcarbamoyloxy group, 2-isopropylphenylcarbamoyloxy group, 3-isopropylphenylcarbamoyloxy group, 4-isopropylphenylcarba Yloxy group, 2-tert-butylphenylcarbamoyloxy group, 3-tert-butylphenylcarbamoyloxy group, 4-tert-butylphenylcarbamoyloxy group, 2-sec-butylphenylcarbamoyloxy group, 3-sec-butylphenylcarbamoyl group Oxy group, 4-sec-butylphenylcarbamoyloxy group, 2-n-heptafluoropropylphenylcarbamoyloxy group, 3-n-heptafluoropropylphenylcarbamoyloxy group, 4-n-heptafluoropropylphenylcarbamoyloxy group, 4 -N-pentylphenylcarbamoyloxy group, 4-n-hexylphenylcarbamoyloxy group, 2,4-dimethylphenylcarbamoyloxy group, 2,4,6-trimethylphenylcarbamoy Ruoxy group, 3,4-dimethoxyphenylcarbamoyloxy group, 3,4,5-trimethoxyphenylcarbamoyloxy group, 2-methoxyphenylcarbamoyloxy group, 3-methoxyphenylcarbamoyloxy group, 4-methoxyphenylcarbamoyloxy group, 2-methoxy-3-chlorophenylcarbamoyloxy group, 2-fluoro-3-methoxyphenylcarbamoyloxy group, 2-fluoro-4-methoxyphenylcarbamoyloxy group, 2,6-dimethoxyphenylcarbamoyloxy group, 2,3,4 -Trifluorophenylcarbamoyloxy group, 3,4,5-trifluorophenylcarbamoyloxy group, 2-trifluoromethoxyphenylcarbamoyloxy group, 3-trifluoromethoxyphenylcarbamoyloxy group 4-trifluoromethoxyphenylcarbamoyloxy group, 2-pentafluoroethoxyphenylcarbamoyloxy group, 3-pentafluoroethoxyphenylcarbamoyloxy group, 4-pentafluoroethoxyphenylcarbamoyloxy group, 2-isopropoxyphenylcarbamoyloxy group, 3-isopropoxyphenylcarbamoyloxy group, 4-isopropoxyphenylcarbamoyloxy group, 2-tert-butoxyphenylcarbamoyloxy group, 3-tert-butoxyphenylcarbamoyloxy group, 4-tert-butoxyphenylcarbamoyloxy group, 2- sec-butoxyphenylcarbamoyloxy group, 3-sec-butoxyphenylcarbamoyloxy group, 4-sec-butoxyphenylcarbamoyl group Xy group, 2-n-heptafluoropropoxyphenylcarbamoyloxy group, 3-n-heptafluoropropoxyphenylcarbamoyloxy group, 4-n-heptafluoropropoxyphenylcarbamoyloxy group, 4-n-pentyloxyphenylcarbamoyloxy group, A carbamoyloxy group such as 4-n-hexyloxyphenylcarbamoyloxy group (on the amino group, a C1-6 alkyl group and a phenyl group [on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 alkyl 1 to 5 and preferably 1 to 3 groups selected from the group consisting of a group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. ˜2 may be substituted).

  Examples of the halogen-substituted or unsubstituted C1-10 alkyl group include, in addition to a halogen-substituted or unsubstituted C1-6 alkyl group, a heptyl group, an octyl group, a nonyl group, a decyl group, and a 7-fluoroheptyl group. 7,7,6-trifluoroheptyl group, 7,7,7,6,6,5,5-heptafluoroheptyl group, 8-chlorooctyl group, 8,8-dibromooctyl group, 6,7 , 8-trifluorooctyl group, 8,8,8,7,7,6,6-heptafluorooctyl group, 8,8,8,7,7-pentachlorooctyl group, 9-iodononyl group, 9, 9-dibromononyl group, 9,9,9,8,8-pentachlorononyl group, 9,9,9,8,8,7,7-heptafluorononyl group, 10-chlorodecyl group, 10,10-dibromo Decyl group, 10, 10, 10, A C1-10 alkyl group substituted with 1 to 7 halogen atoms and a C1-10 alkyl group such as a tetrachlorodecyl group, 10,10,10,9,9,9,8,8-heptafluorodecyl group, Can be mentioned.

  Phenyl group [on the phenyl ring, C1-4 alkylenedioxy group, cyano group, phenoxy group, C1-6 alkylthio group, C1-6 alkanoyl group, phenyl group, phenyl C1-6 alkyl group, halogen atom, halogen substitution Or at least one group selected from the group consisting of an unsubstituted C1-10 alkyl group and a halogen-substituted or unsubstituted C1-10 alkoxy group may be substituted], for example, a phenyl group (phenyl On the ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. ) May be substituted), 4-cyanophenyl group, 3-cyanophenyl group, 2-cyanophenyl group, 3,4-disi Nophenyl group, 3,4,5-tricyanophenyl group, 4-phenoxyphenyl group, 3-phenoxyphenyl group, 2-phenoxyphenyl group, 3,4-diphenoxyphenyl group, 2,4,6-triphenoxyphenyl Group, 4-methylthiophenyl group, 3-methylthiophenyl group, 2-methylthiophenyl group, 3,4-dimethylthiophenyl group, 2,4,6-trimethylthiophenyl group, 4-acetylphenyl group, 3-acetylphenyl Group, 2-acetylphenyl group, 3,4-diacetylphenyl group, 2,4,6-triacetylphenyl group, 4-biphenyl group, 3-biphenyl group, 2-biphenyl group, 3,4-diphenylphenyl group, 2,4,6-triphenylphenyl group, 4-heptyloxyphenyl group, 3-octyloxyphenyl group, 2 Nonyloxyphenyl group, 4-decyloxyphenyl group, 2,4-diheptyloxyphenyl group, 2,4,6-triheptyloxyphenyl group, 4- (7,7-dichloroheptyloxy) phenyl group, 4- Benzylphenyl group, 3-benzylphenyl group, 2-benzylphenyl group, 2,4-dibenzylphenyl group, 2,4,6-tribenzylphenyl group, 4-octylphenyl group, 4-heptylphenyl group, 3- Octylphenyl group, 3- (8,8,8-trifluorooctyl) phenyl group, 2-nonylphenyl group, 4-decylphenyl group, 2,4-dioctylphenyl group, 2,4,6-trioctylcyphenyl Group, 4-phenyl-3-chlorophenyl group, 4-phenoxy-3-methylthiophenyl group, 4-heptyloxy-3-trifluoro Phenyl groups such as romethoxyphenyl group, 4-octyl-2-trifluoromethylphenyl group, 4-benzyl-2-methylphenyl group, 3,4-ethylenedioxyphenyl group, 3,4-methylenedioxyphenyl group [On the phenyl ring, C1-4 alkylenedioxy group, cyano group, phenoxy group, C1-6 alkylthio group, C1-6 alkanoyl group, phenyl group, phenyl C1-6 alkyl group, halogen atom, halogen-substituted or 1 to 5, preferably 1 to 3, groups selected from the group consisting of a substituted C1-10 alkyl group and a halogen-substituted or unsubstituted C1-10 alkoxy group may be substituted (the substituent is C1 In the case of a -4 alkylenedioxy group, it may be substituted by 1-2))].

Carbamoyloxy-substituted C1-6 alkyl group (on the amino group, C1-6 alkyl group, phenyl C1-6 alkyl group, C3-8 cycloalkyl group, naphthyl group, 2,3-dihydro-1H-indenyl group, 2 , 3-dihydrobenzofuryl group and phenyl group [on the phenyl ring, C1-4 alkylenedioxy group, cyano group, phenoxy group, C1-6 alkylthio group, C1-6 alkanoyl group, phenyl group, phenyl C1-6 From the group consisting of an alkyl group, a halogen atom, a halogen-substituted or unsubstituted C1-10 alkyl group and a halogen-substituted or unsubstituted C1-10 alkoxy group may be substituted] As at least one group selected from the group consisting of optionally substituted), for example, a carbamoyloxymethyl group, -Carbamoyloxyethyl group, 1-carbamoyloxyethyl group, 3-carbamoyloxypropyl group, 4-carbamoyloxybutyl group, 5-carbamoyloxypentyl group, 6-carbamoyloxyhexyl group, phenylcarbamoyloxymethyl group, 2-methyl Phenylcarbamoyloxymethyl group, 3-methylphenylcarbamoyloxymethyl group, 4-methylphenylcarbamoyloxymethyl group, 2,3-dimethylphenylcarbamoyloxymethyl group, 2,4-dimethylphenylcarbamoyloxymethyl group, 2,6- Dimethylphenylcarbamoyloxymethyl group, 2,4,6-trimethylphenylcarbamoyloxymethyl group, 2-trifluoromethylphenylcarbamoyloxymethyl group, 3-trifluoromethyl Enylcarbamoyloxymethyl group, 4-trifluoromethylphenylcarbamoyloxymethyl group, 2,3-ditrifluoromethylphenylcarbamoyloxymethyl group, 2,4-ditrifluoromethylphenylcarbamoyloxymethyl group, 2,6-ditrifluoromethyl Phenylcarbamoyloxymethyl group, 2-pentafluoroethylphenylcarbamoyloxymethyl group, 3-pentafluoroethylphenylcarbamoyloxymethyl group, 4-pentafluoroethylphenylcarbamoyloxymethyl group, 2- (n-propylphenyl) carbamoyloxymethyl Group, 3- (n-propylphenyl) carbamoyloxymethyl group, 4- (n-propylphenyl) carbamoyloxymethyl group, 2- (phenylcarbamoyloxy) Ethyl group, 2- (3-trifluoromethylphenylcarbamoyloxy) ethyl group, 2- (4-trifluoromethylphenylcarbamoyloxy) ethyl group, 2- (2,3-ditrifluoromethylphenylcarbamoyloxy) ethyl group, 2- (2,4-ditrifluoromethylphenylcarbamoyloxy) ethyl group, 2- (2,6-ditrifluoromethylphenylcarbamoyloxy) ethyl group, 2- (2-pentafluoroethylphenylcarbamoyloxy) ethyl group, 2 -(3-pentafluoroethylphenylcarbamoyloxy) ethyl group, 2- (4-pentafluoroethylphenylcarbamoyloxy) ethyl group, 3- (phenylcarbamoyloxy) propyl group, 3- (3-trifluoromethylphenylcarbamoyloxy) ) Pyl group, 3- (4-trifluoromethylphenylcarbamoyloxy) propyl group, 3- (2,3-ditrifluoromethylphenylcarbamoyloxy) propyl group, 3- (2,4-ditrifluoromethylphenylcarbamoyloxy) propyl Group, 3- (2,6-ditrifluoromethylphenylcarbamoyloxy) propyl group, 3- (2-pentafluoroethylphenylcarbamoyloxy) propyl group, 3- (3-pentafluoroethylphenylcarbamoyloxy) propyl group, 3 -(4-pentafluoroethylphenylcarbamoyloxy) propyl group, 4- (4-trifluoromethylphenylcarbamoyloxy) butyl group, 5- (4-trifluoromethylphenylcarbamoyloxy) pentyl group, 6- (4-tri Fluoro Tylphenylcarbamoyloxy) hexyl group, (2-fluorophenylcarbamoyloxy) methyl group, 2- (3-fluorophenylcarbamoyloxy) ethyl group, 1- (4-fluorophenylcarbamoyloxy) ethyl group, 3- (2- Chlorophenylcarbamoyloxy) propyl group, 4- (3-chlorophenylcarbamoyloxy) butyl group, 5- (4-chlorophenylcarbamoyloxy) pentyl group, 6- (2-bromophenylcarbamoyloxy) hexyl group, (3-bromophenylcarbamoyl) Oxy) methyl group, 2- (4-bromophenylcarbamoyloxy) ethyl group, 1- (2-iodophenylcarbamoyloxy) ethyl group, 3- (3-iodophenylcarbamoyloxy) propyl group, 4- (4-iodopheny) Rucarbamoyloxy) butyl group, 5- (2,3-difluorophenylcarbamoyloxy) pentyl group, 6- (3,4-difluorophenylcarbamoyloxy) hexyl group, (3,5-difluorophenylcarbamoyloxy) methyl group, 2 -(2,4-difluorophenylcarbamoyloxy) ethyl group, 1- (2,6-difluorophenylcarbamoyloxy) ethyl group, 3- (2,3-dichlorophenylcarbamoyloxy) propyl group, 4- (3,4- (Dichlorophenylcarbamoyloxy) butyl group, 5- (3,5-dichlorophenylcarbamoyloxy) pentyl group, 6- (2,4-dichlorophenylcarbamoyloxy) hexyl group, (2,6-dichlorophenylcarbamoyloxy) methyl group, 2- ( 3,4,5-tri (Luorophenylcarbamoyloxy) ethyl group, 1- (2,3,4,5,6-pentafluorophenylcarbamoyloxy) ethyl group, 3- (3,4,5-trichlorophenylcarbamoyloxy) propyl group, 4- (2,4,6-trifluorophenylcarbamoyloxy) butyl group, 5- (2,4,6-trichlorophenylcarbamoyloxy) pentyl group, (2-methyl-3-chlorophenylcarbamoyloxy) methyl group, (3- Methyl-4-chlorophenylcarbamoyloxy) methyl group, (2-chloro-4-methylphenylcarbamoyloxy) methyl group, (2-methyl-3-fluorophenylcarbamoyloxy) methyl group, ethylcarbamoyloxymethyl group, n-buty Rucarbamoyloxymethyl group, n-hexylcal Moyloxymethyl group, n-pentylcarbamoyloxymethyl group, N-methyl-N-phenylcarbamoyloxymethyl group, N, N-dimethylcarbamoyloxymethyl group, N-methyl-N-ethylcarbamoyloxymethyl group, 2- [ N- (2-fluorophenyl) -N-methylcarbamoyloxy] ethyl group, 1- [N- (3-fluorophenyl) -N-methylcarbamoyloxy] ethyl group, 3- [N- (4-fluorophenyl) -N-methylcarbamoyloxy] propyl group, 4- [N- (2-chlorophenyl) -N-methylcarbamoyloxy] butyl group, 5- [N- (3-chlorophenyl) -N-methylcarbamoyloxy] pentyl group, 6- [N- (4-chlorophenyl) -N-methylcarbamoyloxy] hexyl group, [ N- (4-bromophenyl) -N-methylcarbamoyloxy] methyl group, 2- [N- (2-iodophenyl) -N-methylcarbamoyloxy] ethyl group, 1- [N- (3-iodophenyl) -N-methylcarbamoyloxy] ethyl group, 3- [N- (4-iodophenyl) -N-methylcarbamoyloxy] propyl group, 4- [N- (2,3-difluorophenyl) -N-methylcarbamoyloxy ] Butyl group, 5- [N- (3,4-difluorophenyl) -N-methylcarbamoyloxy] pentyl group, 6- [N- (3,5-difluorophenyl) -N-methylcarbamoyloxy] hexyl group, [N- (2,4-difluorophenyl) -N-methylcarbamoyloxy] methyl group, 2- [N- (2,6-difluorophenyl) -N- Tylcarbamoyloxy] ethyl group, 1- [N- (2,3-dichlorophenyl) -N-methylcarbamoyloxy] ethyl group, 3- [N- (3,4-dichlorophenyl) -N-methylcarbamoyloxy] propyl group , [N- (3,5-dichlorophenyl) -N-methylcarbamoyloxy] methyl group, 4- [N- (2,4-dichlorophenyl) -N-methylcarbamoyloxy] butyl group, 5- [N- (2 , 6-Dichlorophenyl) -N-methylcarbamoyloxy] pentyl group, 6- [N- (3,4,5-trifluorophenyl) -N-methylcarbamoyloxy] hexyl group, [N- (3,4,5 -Trichlorophenyl) -N-methylcarbamoyloxy] methyl group, 2- [N- (2,4,6-trifluorophenyl) -N-methyl Rubamoyloxy] ethyl group, 1- [N- (2,4,6-trichlorophenyl) -N-methylcarbamoyloxy] ethyl group, 3- [N- (2-methylphenyl) -N-methylcarbamoyloxy] propyl group 4- [N- (3-methylphenyl) -N-methylcarbamoyloxy] butyl group, 5- [N- (4-methylphenyl) -N-methylcarbamoyloxy] hexyl group, 6- [N- (2 -Methyl-3-chlorophenyl) -N-methylcarbamoyloxy] hexyl group, [N- (3-methyl-4-chlorophenyl) -N-methylcarbamoyloxy] methyl group, 2- [N- (2-chloro-4) -Methylphenyl) -N-methylcarbamoyloxy] ethyl group, 1- [N- (2-methyl-3-fluorophenyl) -N-methylcarbamoyl Oxy] ethyl group, 3- [N- (2-trifluoromethylphenyl) -N-methylcarbamoyloxy] propyl group, 4- [N- (4-trifluoromethylphenyl) -N-methylcarbamoyloxy] butyl group 2- [N- (4-trifluoromethylphenyl) -N-methylcarbamoyloxy] ethyl group, 5- [N-phenyl-N-phenylcarbamoyloxy] pentyl group, 6- [N-phenyl-N- ( 2-fluorophenyl) carbamoyloxy] hexyl group, [N-phenyl-N- (3-fluorophenyl) carbamoyloxy] methyl group, 2- [N-phenyl-N- (4-fluorophenyl) carbamoyloxy] ethyl group 1- [N-phenyl-N- (2-chlorophenyl) carbamoyloxy] ethyl group, 1- [N-pheny -N- (3-chlorophenyl) carbamoyloxy] ethyl group, 3- [N-phenyl-N- (4-chlorophenyl) carbamoyloxy] propyl group, 4- [N-phenyl-N- (2-bromophenyl) carbamoyl Oxy] butyl group, 5- [N-phenyl-N- (3-bromophenyl) carbamoyloxy] pentyl group, 6- [N-phenyl-N- (4-bromophenyl) carbamoyloxy] hexyl group, [N- Phenyl-N- (2-iodophenyl) carbamoyloxy] methyl group, 1- [N-phenyl-N- (3-iodophenyl) carbamoyloxy] ethyl group, 2- [N-phenyl-N- (4-iodo) Phenyl) carbamoyloxy] ethyl group, 1- [N-phenyl-N- (2,3-difluorophenyl) carbamoyloxy Ethyl group, 3- [N-phenyl-N- (3,4-difluorophenyl) carbamoyloxy] propyl group, 4- [N-phenyl-N- (3,5-difluorophenyl) carbamoyloxy] butyl group, 5 -[N-phenyl-N- (2,4-difluorophenyl) carbamoyloxy] pentyl group, 6- [N-phenyl-N- (2,6-difluorophenyl) carbamoyloxy] hexyl group, [N-phenyl- N- (2,3-dichlorophenyl) carbamoyloxy] methyl group, 2- [N-phenyl-N- (3,4-dichlorophenyl) carbamoyloxy] ethyl group, 1- [N-phenyl-N- (3,5 -Dichlorophenyl) carbamoyloxy] ethyl group, 3- [N-phenyl-N- (2,4-dichlorophenyl) carbamoyloxy] Propyl group, 4- [N-phenyl-N- (2,6-dichlorophenyl) carbamoyloxy] butyl group, 5- [N-phenyl-N- (3,4,5-trifluorophenyl) carbamoyloxy] pentyl group , 6- [N-phenyl-N- (3,4,5-trichloropheny



L) carbamoyloxy] hexyl group, [N-phenyl-N- (2,4,6-trifluorophenyl) carbamoyloxy] methyl group, 2- [N-phenyl-N- (2,4,6-trichlorophenyl) ) Carbamoyloxy] ethyl group, 1- [N-phenyl-N- (2-methylphenyl) carbamoyloxy] ethyl group, 3- [N-phenyl-N- (3-methylphenyl) carbamoyloxy] propyl group, 4 -[N-phenyl-N- (4-methylphenyl) carbamoyloxy] butyl group, 5- [N-phenyl-N- (2-methyl-3-chlorophenyl) carbamoyloxy] pentyl group, 6- [N-phenyl] -N- (3-methyl-4-chlorophenyl) carbamoyloxy] hexyl group, [N-phenyl-N- (2-chloro-4-methylphenyl) Nyl) carbamoyloxy] methyl group, [N-phenyl-N- (2-methyl-3-fluorophenyl) carbamoyloxy] methyl group, 2- [N-phenyl-N- (2-trifluoromethylphenyl) carbamoyloxy ] Ethyl group, 1- [N-phenyl-N- (3-trifluoromethylphenyl) carbamoyloxy] ethyl group, 3- [N-phenyl-N- (4-trifluoromethylphenyl) carbamoyloxy] propyl group, 2-isopropylphenylcarbamoyloxymethyl group, 3-isopropylphenylcarbamoyloxymethyl group, 4-isopropylphenylcarbamoyloxymethyl group, 2-tert-butylphenylcarbamoyloxymethyl group, 4-n-butylphenylcarbamoyloxymethyl group, 2 -Methyl-4 Chlorophenylcarbamoyloxymethyl group, 3-tert-butylphenylcarbamoyloxymethyl group, 4-tert-butylphenylcarbamoyloxymethyl group, 2-sec-butylphenylcarbamoyloxymethyl group, 3-sec-butylphenylcarbamoyloxymethyl group, 4-sec-butylphenylcarbamoyloxymethyl group, 4-pentylphenylcarbamoyloxymethyl group, 4-hexylphenylcarbamoyloxymethyl group, 3,4-dimethoxyphenylcarbamoyloxymethyl group, 3,4,5-trimethoxyphenylcarbamoyl Oxymethyl group, 2-methoxyphenylcarbamoyloxymethyl group, 3-methoxyphenylcarbamoyloxymethyl group, 4-methoxyphenylcarbamoyloxymethyl Group, 2-methoxy-3-chlorophenylcarbamoyloxymethyl group, 2- (2-fluoro-3-methoxyphenylcarbamoyloxy) ethyl group, 1- (2-fluoro-4-methoxyphenylcarbamoyloxy) ethyl group, 3- (2,6-dimethoxyphenylcarbamoyloxy) propyl group, 4- (2,3,4-trifluorophenylcarbamoyloxy) butyl group, 5- (3,4,5-trifluorophenylcarbamoyloxy) pentyl group, 6 -(2-trifluoromethoxyphenylcarbamoyloxy) hexyl group, 3-trifluoromethoxyphenylcarbamoyloxymethyl group, 4-trifluoromethoxyphenylcarbamoyloxymethyl group, 2- (4-trifluoromethoxyphenylcarbamoyloxy) ethyl group 2 [N-methyl-N- (4-trifluoromethoxyphenyl) carbamoyloxy] ethyl group, 3-trifluoromethylphenylcarbamoyloxymethyl group, 4-trifluoromethylphenylcarbamoyloxymethyl group, 3-trifluoromethyl-4 -Chlorophenylcarbamoyloxymethyl group, 3,5-ditrifluoromethoxyphenylcarbamoyloxymethyl group, 2,4-dichlorophenylcarbamoyloxymethyl group, 2-chlorophenylcarbamoyloxymethyl group, 3-chlorophenylcarbamoyloxymethyl group, 4-chlorophenylcarbamoyl group Oxymethyl group, 3,5-dichlorophenylcarbamoyloxymethyl group, 3,4-dichlorophenylcarbamoyloxymethyl group, 2-fluorophenylcarbamoylo Cymethyl group, 3-fluorophenylcarbamoyloxymethyl group, 4-fluorophenylcarbamoyloxymethyl group, 2-pentafluoroethoxyphenylcarbamoyloxymethyl group, 3-pentafluoroethoxyphenylcarbamoyloxymethyl group, 4-pentafluoroethoxyphenylcarbamoyl Oxymethyl group, 2-isopropoxyphenylcarbamoyloxymethyl group, 3-isopropoxyphenylcarbamoyloxymethyl group, 4-isopropoxyphenylcarbamoyloxymethyl group, 2-tert-butoxyphenylcarbamoyloxymethyl group, 4-n-butoxy Phenylcarbamoyloxymethyl group, 3-methoxyphenylcarbamoyloxymethyl group, 4-methoxyphenylcarbamoyloxymethyl group, 4- Ethoxyphenylcarbamoyloxymethyl group, 3-tert-butoxyphenylcarbamoyloxymethyl group, 4-tert-butoxyphenylcarbamoyloxymethyl group, 2-sec-butoxyphenylcarbamoyloxymethyl group, 3-sec-butoxyphenylcarbamoyloxymethyl group 4-sec-butoxyphenylcarbamoyloxymethyl group, 2-n-heptafluoropropoxyphenylcarbamoyloxymethyl group, 3-n-heptafluoropropoxyphenylcarbamoyloxymethyl group, 4-n-heptafluoropropoxyphenylcarbamoyloxymethyl group 4-n-pentyloxyphenylcarbamoyloxymethyl group, 4-n-hexyloxyphenylcarbamoyloxymethyl group, 4-cyanophenyl Rubamoyloxymethyl group, [N-methyl-N- (3-cyanophenyl) carbamoyloxy] methyl group, 2-cyanophenylcarbamoyloxymethyl group, 3,4-dicyanophenylcarbamoyloxymethyl group, 3,4,5 -Tricyanophenylcarbamoyloxymethyl group, 4-phenoxyphenylcarbamoyloxymethyl group, [N-methyl-N- (3-phenoxyphenyl) carbamoyloxy] methyl group, 2-phenoxyphenylcarbamoyloxymethyl group, 3,4- Diphenoxyphenylcarbamoyloxymethyl group, 2,4,6-triphenoxyphenylcarbamoyloxymethyl group, 4-methylthiophenylcarbamoyloxymethyl group, [N-methyl-N- (4-methylthiophenyl) carbamoyloxy] methyl 3-methylthiophenylcarbamoyloxymethyl group, 2-methylthiophenylcarbamoyloxymethyl group, 3,4-dimethylthiophenylcarbamoyloxymethyl group, 2,4,6-trimethylthiophenylcarbamoyloxymethyl group, 4-acetylphenylcarbamoyl Oxymethyl group, 3-acetylphenylcarbamoyloxymethyl group, 2-acetylphenylcarbamoyloxymethyl group, 3,4-diacetylphenylcarbamoyloxymethyl group, [N-methyl-N- (3,4-diacetylphenyl) carbamoyloxy ] Methyl group, 2,4,6-triacetylphenylcarbamoyloxymethyl group, 4-biphenylcarbamoyloxymethyl group, 3-biphenylcarbamoyloxymethyl group, 2-biphenylcarbamoyl Oxymethyl group, [N-methyl-N- (2-biphenyl) carbamoyloxy] methyl group, 3,4-diphenylphenylcarbamoyloxymethyl group, 2,4,6-triphenylphenylcarbamoyloxymethyl group, 4-n -Heptyloxyphenylcarbamoyloxymethyl group, [N-methyl-N-4- (n-heptyloxyphenyl) carbamoyloxy] methyl group, 3-n-octyloxyphenylcarbamoyloxymethyl group, 2-n-nonyloxyphenyl Carbamoyloxymethyl group, 4-n-decyloxyphenylcarbamoyloxymethyl group, 2,4-di-n-heptyloxyphenylcarbamoyloxymethyl group, 2,4,6-tri-n-heptyloxyphenylcarbamoyloxymethyl group, 4 -(7,7-dichlorohept Ruoxy) phenylcarbamoyloxymethyl group, 4-benzylphenylcarbamoyloxymethyl group, [N-methyl-N- (4-benzylphenyl) carbamoyloxy] methyl group, 3-benzylphenylcarbamoyloxymethyl group, 2-benzylphenylcarbamoyl Oxymethyl group, 2,4-dibenzylphenylcarbamoyloxymethyl group, 2,4,6-tribenzylphenylcarbamoyloxymethyl group, 4-n-octylphenylcarbamoyloxymethyl group, [N-methyl-N- (4 -N-octylphenyl) carbamoyloxy] methyl group, 3-n-heptylphenylcarbamoyloxymethyl group, 2-n-octylphenylcarbamoyloxymethyl group, 3- (8,8,8-trifluorooctyl) phenylcarbamo Ruoxymethyl group, 4-n-nonylphenylcarbamoyloxymethyl group, 3-n-decylphenylcarbamoyloxymethyl group, 2,4-di-n-octylphenylcarbamoyloxymethyl group, 2,4,6-tri-n-octylsi Phenylcarbamoyloxymethyl group, 4-phenyl-3-chlorophenylcarbamoyloxymethyl group, 4-phenoxy-3-methylthiophenylcarbamoyloxymethyl group, 4-n-heptyloxy-3-trifluoromethoxyphenylcarbamoyloxymethyl group, 4 -N-octyl-2-trifluoromethylphenylcarbamoyloxymethyl group, 4-benzyl-2-methylphenylcarbamoyloxymethyl group, 3,4-ethylenedioxyphenylcarbamoyloxymethyl group, 3,4-methylenedi Oxyphenylcarbamoyloxymethyl group, benzylcarbamoyloxymethyl group, 2-phenylethylcarbamoyloxymethyl group, cyclohexylcarbamoyloxymethyl group, 1-naphthylcarbamoyloxymethyl group, 2-naphthylcarbamoyloxymethyl group, 5- (2,3 -Dihydro-1H-indenyl) carbamoyloxymethyl group, 5- (2,3-dihydrobenzofuryl) carbamoyloxymethyl group, [N-methyl-N- (3,4-methylenedioxyphenyl) carbamoyloxy] methyl group , (N-methyl-N-benzylcarbamoyloxy) methyl group, [N-methyl-N- (2-phenylethyl) carbamoyloxy] methyl group, (N-methyl-N-cyclohexylcarbamoyloxy) methyl group, [N -Methyl- -(1-naphthyl) carbamoyloxy] methyl group, [N-methyl-N- (2-naphthyl) carbamoyloxy] methyl group, {N-methyl-N- [5- (2,3-dihydro-1H-indenyl) )] Carbamoyloxy} methyl group, [N-methyl-N- (2,3-dihydro-5-benzofuryl) carbamoyloxy] methyl group and other carbamoyloxy substituted C1-6 alkyl groups (on the amino group, C1 6 alkyl groups, phenyl C1-6 alkyl groups described above, C3-8 cycloalkyl groups described above, naphthyl groups, 2,3-dihydro-1H-indenyl groups, 2,3-dihydrobenzofuryl groups and Phenyl group [on the phenyl ring, C1-4 alkylenedioxy group, cyano group, phenoxy group, C1-6 alkylthio group, C1-6 alkano A group selected from the group consisting of a ru group, a phenyl group, a phenyl C1-6 alkyl group, a halogen atom, a halogen-substituted or unsubstituted C1-10 alkyl group and a halogen-substituted or unsubstituted C1-10 alkoxy group; 5 or preferably 1 to 3 may be substituted (in the case where the substituent is a C1 to 4 alkylenedioxy group, 1 or 2 may be substituted)]. 1 to 2 groups may be substituted).

  Examples of the C1-6 alkanoyl-substituted C1-6 alkyl group include an acetylmethyl group, 2-propionylethyl group, 1-butyrylethyl group, 2-acetylethyl group, 3-acetylpropyl group, 4-acetylbutyl group, 4- Isobutyrylbutyl group, 5-pentanoylpentyl group, 6-acetylhexyl group, 6-tert-butylcarbonylhexyl group, 1,1-dimethyl-2-hexanoylethyl group, 2-methyl-3-acetylpropyl group Etc.

Phenoxy C1-6 alkyl group (on the phenyl ring, halogen atom; C1-4 alkylenedioxy group; C1-6 alkoxycarbonyl group; phenyl group; phenoxy group; pyrrolyl group; benzothiazolyl group; 1,2,4-triazolyl Group: imidazolyl group; isoxazolyl group; benzoxazolyl group; benzotriazolyl group; cyano group; nitro group; C2-6 alkenyl group; C1-6 alkanoyl group; C1-6 alkoxycarbonyl-substituted C1-6 alkyl group; A C1-6 alkanoyl-substituted C1-6 alkyl group; a group -N ( ^R11B ) ^R12B ( ^R11B and ^R12B are the same or different and each represents a hydrogen atom, a C1-6 alkyl group, a C1-6 alkanoyl group or a phenyl group; .R ^11B and R ^12B shows, together with the adjacent nitrogen atom, also via a nitrogen atom, an oxygen atom or a sulfur atom And may form a 5- to 7-membered saturated heterocyclic ring without any intervening via a C1-6 alkoxycarbonyl group and an amino group [on the amino group, a phenyl group (phenyl ring). On the top, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) And at least one group selected from the group consisting of C1-6 alkyl groups may be substituted], at least one group selected from the group consisting of: 6 alkoxy group; phenyl C1-6 alkyl group; C1-6 alkylthio group; C3-8 cycloalkyl group; halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C At least one group selected from the group consisting of 1 to 10 alkoxy groups may be substituted). ], For example, selected from the group consisting of a phenoxy C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) In addition, a 3,4-methylenedioxyphenoxymethyl group, a 3,4-ethylenedioxyphenoxymethyl group, a 4-ethoxycarbonylphenoxymethyl group, 3) -Methoxycarbonylphenoxymethyl group, 2-ethoxycarbonylphenoxymethyl group, 2,4-diethoxycarbonylphenoxymethyl group, 2,4,6-triethoxycarbonylphenoxymethyl group, 2-ethoxycarbonyl-4-methylphenoxymethyl group 2-methoxycarbonyl-4-methoxyphenoxymethyl 2-methoxycarbonyl-3-methoxyphenoxymethyl group, 2- (4-ethoxycarbonylphenoxy) ethyl group, 4-cyanophenoxymethyl group, 3-cyanophenoxymethyl group, 2-cyanophenoxymethyl group, 2,4- Dicyanophenoxymethyl group, 2,4,6-tricyanophenoxymethyl group, 2- (4-cyanophenoxy) ethyl group, 4-nitrophenoxymethyl group, 3-nitrophenoxymethyl group, 2-nitrophenoxymethyl group, 2 , 4-Dinitrophenoxymethyl group, 2,4,6-trinitrophenoxymethyl group, 2- (4-nitrophenoxy) ethyl group, 4-allylphenoxymethyl group, 3-allylphenoxymethyl group, 2-allylphenoxymethyl group Group, 3,4-diallylphenoxymethyl group, 3,4,5-tria Ruphenoxymethyl group, 2- (4-allylphenoxy) ethyl group, 2- (3-allylphenoxy) ethyl group, 3-diethylaminophenoxymethyl group, 3-anilinophenoxymethyl group, 4-acetylaminophenoxymethyl group, 2,4,6-tri (diethylamino) phenoxymethyl group, 2-anilinophenoxymethyl group, 2,4-diacetylaminophenoxymethyl group, 2- (3-diethylaminophenoxy) ethyl group, 2- (3-anilino Phenoxy) ethyl group, 2- [4- (2-acetylethyl) phenoxy] ethyl group, 4- (2-acetylethyl) phenoxymethyl group, 3-acetylmethylphenoxymethyl group, 2- (3-acetylpropyl) phenoxy Methyl group, 2,4-di (2-acetylethyl) phenoxymethyl group, 2,4 , 6-tri (2-acetylethyl) phenoxymethyl group, 4-methoxycarbonylmethylphenoxymethyl group, 3-ethoxycarbonylmethylphenoxymethyl group, 2-methoxycarbonylmethylphenoxymethyl group, 2,4-dimethoxycarbonylmethylphenoxymethyl group Group, 2,4,6-trimethoxycarbonylmethylphenoxymethyl group, 2- (4-methoxycarbonylmethylphenoxy) ethyl group, 4-propionylphenoxymethyl group, 4-acetylphenoxymethyl group, 3-propionylphenoxymethyl group, 2-acetylphenoxymethyl group, 2,4-dipropionylphenoxymethyl group, 2,4,6-triacetylphenoxymethyl group, 2- (4-propionylphenoxy) ethyl group, 2-benzylphenoxymethyl group, 3 Benzylphenoxymethyl group, 4-benzylphenoxymethyl group, 2,3-dibenzylphenoxymethyl group, 3,4,5-tribenzylphenoxymethyl group, 4-methylthiophenoxymethyl group, 3-methylthiophenoxymethyl group, 2- Methylthiophenoxymethyl group, 2,4-dimethylthiophenoxymethyl group, 2,4,6-trimethylthiophenoxymethyl group, 2- (4-methylthiophenoxy) ethyl group, 4-cyclopentylphenoxymethyl group, 3-cyclohexylphenoxymethyl group Group, 4-cyclohexylphenoxymethyl group, 2-cycloheptylphenoxymethyl group, 2,4-dicyclopentylphenoxymethyl group, 2,4-cyclopentyl-6-cyclooctylphenoxymethyl group, 2- (4-cyclohexylphenoxy group) Ethyl group, 2- (4-cyclopentylphenoxy) ethyl group, 4-n-octyloxyphenoxymethyl group, 2- (4-n-octyloxyphenoxy) ethyl group, 4-phenylphenoxymethyl group, 3-phenylphenoxymethyl Group, 2-phenylphenoxymethyl group, 2,4-diphenylphenoxymethyl group, 2,4,6-triphenylphenoxymethyl group, 2- (4-phenylphenoxy) ethyl group, 4-phenoxyphenoxymethyl group, 3- Phenoxyphenoxymethyl group, 2-phenoxyphenoxymethyl group, 2,4-diphenoxyphenoxymethyl group, 2,4,6-triphenoxyphenoxymethyl group, 2- (3-phenoxyphenoxy) ethyl group, 4-benzyloxyphenoxy Methyl group, 3-benzyloxyphenoxymethyl Group, 2-benzyloxyphenoxymethyl group, 2,4-dibenzyloxyphenoxymethyl group, 2,4,6-tribenzyloxyphenoxymethyl group, 2- (4-benzyloxyphenoxy) ethyl group, 2,4 -Dibenzylphenoxymethyl group, 2,4,6-tribenzylphenoxymethyl group, 2- (4-benzylphenoxy) ethyl group, 4- (1-pyrrolyl) phenoxymethyl group, 3- (1-pyrrolyl) phenoxymethyl Group, 2- (1-pyrrolyl) phenoxymethyl group, 2,4-di (1-pyrrolyl) phenoxymethyl group, 2,4,6-tri (1-pyrrolyl) phenoxymethyl group, 2- (2-benzothiazolyl) Phenoxymethyl group, 2- (2-benzothiazolyl) phenoxymethyl group, 3- (2-benzothiazolyl) phenoxymethyl group 2,4,6-tri (5-benzothiazolyl) phenoxymethyl group, 2,4-di (6-benzothiazolyl) phenoxymethyl group, 4- (1-1,2,4-triazolyl) phenoxymethyl group, 3- ( 1-1,2,4-triazolyl) phenoxymethyl group, 2- (1-1,2,4-triazolyl) phenoxymethyl group, 4- (3-1,2,4-triazolyl) phenoxymethyl group, 2, 4-di (5-1,2,4-triazolyl) phenoxymethyl group, 2,4,6-tri (1-1,2,4-triazolyl) phenoxymethyl group, 4- (5-isoxazolyl) phenoxymethyl group 3- (3-isoxazolyl) phenoxymethyl group, 2- (4-isoxazolyl) phenoxymethyl group, 2- (5-isoxazolyl) phenoxymethyl group, 2, -Di (5-isoxazolyl) phenoxymethyl group, 2,4,6-tri (5-isoxazolyl) phenoxymethyl group, 4- (1-imidazolyl) phenoxymethyl group, 3- (2-imidazolyl) phenoxymethyl group, 2 -(4-imidazolyl) phenoxymethyl group, 2,4-di (1-imidazolyl) phenoxymethyl group, 2,4,6-tri (1-imidazolyl) phenoxymethyl group, 4- (1-benzotriazolyl) Phenoxymethyl group, 3- (1-benzotriazolyl) phenoxymethyl group, 2- (1-benzotriazolyl) phenoxymethyl group, 2- (1-benzotriazolyl) phenoxymethyl group, 2,4- Di (1-benzotriazolyl) phenoxymethyl group, 2,4,6-tri (1-benzotriazolyl) phenoxymethyl group, 4 -(6-Benzimidazolyl) phenoxymethyl group, 3- (5-Benzimidazolyl) phenoxymethyl group, 2- (2-Benzimidazolyl) phenoxymethyl group, 2- (1-benzotriazolyl) phenoxymethyl group, 2,4- Di (2-benzimidazolyl) phenoxymethyl group, 2,4,6-tri (2-benzimidazolyl) phenoxymethyl group, 4- (4-tert-butoxycarbonyl-1-piperazinyl) phenoxymethyl group, 2- [4- { 4- [4- (N- (4-chlorophenyl) -N-methylamino)]-1-piperidyl} phenoxy] ethyl group, 2- [4- (1-1,2,4-triazolyl) phenoxy] ethyl group 2- [2- (5-isoxazolyl) phenoxy] ethyl group, 2- (2-methoxy-4-allylphenoxy) Ethyl group, 2- (2-fluoro-4-nitrophenoxy) ethyl group, 2- (2-ethoxy-5-allylphenoxy) ethyl group, 2-fluoro-4-nitrophenoxymethyl group, 2-methoxy-4- Phenoxy C1-6 alkyl groups such as allylphenoxymethyl group, 2-ethoxy-5-allylphenoxymethyl group, 2-methyl-4-acetylphenoxymethyl group (on the phenyl ring, halogen atom; C1-4 alkylenedioxy C1-6 alkoxycarbonyl group; phenyl group; phenoxy group; pyrrolyl group; benzothiazolyl group; 1,2,4-triazolyl group; imidazolyl group; isoxazolyl group; benzoxazolyl group; Nitro group; C2-6 alkenyl group; C1-6 alkanoyl group; C1-6 alkoxy Carbonyl-substituted Cl to 6 alkyl radical; Cl to 6 alkanoyl substituted Cl to 6 alkyl radical; group ^{-N (R 11B) R 12B (} R 11B and R ^12B are each independently hydrogen, Cl to 6 alkyl groups, C1 -6 represents an alkanoyl group or a phenyl group. R ^11B and R ^12B may be combined with an adjacent nitrogen atom to form a 5- to 7-membered saturated heterocyclic ring, with or without a nitrogen atom, oxygen atom or sulfur atom. On the heterocyclic ring, a C1-6 alkoxycarbonyl group and an amino group [on the amino group, a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or 1 to 5, preferably 1 to 3 groups selected from the group consisting of unsubstituted C1-6 alkoxy groups) and a group selected from the group consisting of C1-6 alkyl groups 1 to 2 groups optionally selected from the group consisting of 1 to 2 may be substituted); phenyl C1-6 alkoxy group; phenyl C1-6 alkyl group; C1-6 alkylthio Group: C3-8 cycloalkyl group; 1-5 groups selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-10 alkoxy group, preferably 1- (If substituents are C1~4 alkylenedioxy group, it is preferable is one to two substituents) may also be individual substitutions are shown a). ] Can be mentioned.

  Examples of the tetrahydropyranyloxy C1-6 alkyl group include a (2-tetrahydropyranyloxy) methyl group, a 2- (3-tetrahydropyranyloxy) ethyl group, and a 1- (4-tetrahydropyranyloxy) ethyl group. 2- (2-tetrahydropyranyloxy) ethyl group, 3- (2-tetrahydropyranyloxy) propyl group, 4- (2-tetrahydropyranyloxy) butyl group, 4- (3-tetrahydropyranyloxy) Butyl group, 5- (2-tetrahydropyranyloxy) pentyl group, 6- (2-tetrahydropyranyloxy) hexyl group, 6- (2-tetrahydropyranyloxy) hexyl group, 1,1-dimethyl-2- (4-Tetrahydropyranyloxy) ethyl group, 2-methyl-3- (3-tetrahydropyranyloxy) pro It can be exemplified Le group.

  As the furyl C1-6 alkoxy substituted C1-6 alkyl group (on the furan ring, at least one C1-6 alkoxycarbonyl group may be substituted), for example, [(2-furyl) methoxy] methyl Group, [2- (3-furyl) ethoxy] methyl group, [3- (2-furyl) propoxy] methyl group, [2- (3-furyl) propoxy] methyl group, [4- (2-furyl) butoxy ] Methyl group, [5- (3-furyl) pentoxy] methyl group, [4- (2-furyl) pentoxy] methyl group, [6- (3-furyl) hexyloxy] methyl group, 2-[(2- Furyl) methoxy] ethyl group, 1- [2- (3-furyl) ethoxy] ethyl group, 3- [3- (2-furyl) propoxy] propyl group, 4- [2- (3-furyl) propoxy] butyl Group, 5- [4 (2-furyl) butoxy] hexyl group, 1,1-dimethyl-2- [5- (3-furyl) pentoxy] ethyl group, 2-methyl-3- [4- (2-furyl) pentoxy] propyl group, 2- [6- (3-furyl) hexyloxy] ethyl group, [(5-ethoxycarbonyl-2-furyl) methoxy] methyl group, [(4-methoxycarbonyl-2-furyl) methoxy] methyl group, [( 3-propoxycarbonyl-2-furyl) methoxy] methyl group, [(5-butoxycarbonyl-2-furyl) methoxy] methyl group, [(4-pentyloxycarbonyl-2-furyl) methoxy] methyl group, [(3 -Hexyloxycarbonyl-2-furyl) methoxy] methyl group, [(3,5-diethoxycarbonyl-2-furyl) methoxy] methyl group, [(3,4,5 Furyl C1-6 alkoxy-substituted C1-6 alkyl group such as triethoxycarbonyl-2-furyl) methoxy] methyl group (on the furan ring, 1 to 3 C1-6 alkoxycarbonyl groups may be substituted) ).

  Examples of the C3-8 cycloalkyl C1-6 alkyl group include cyclohexylmethyl group, 2-cyclopropylethyl group, 1-cyclopentylethyl group, 3-cyclobutylpropyl group, 4-cyclohexylbutyl group, and 5-cycloheptylpentyl. Group, 6-cyclooctylhexyl group, 1,1-dimethyl-2-cyclohexylethyl group, 2-methyl-3-cyclohexylpropyl group and the like.

  Tetrazolyl C1-6 alkoxy-substituted C1-6 alkyl group (on the tetrazole ring, phenyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of 6 alkoxy groups may be substituted), a group selected from the group consisting of phenyl C1-6 alkyl groups and C3-8 cycloalkyl C1-6 alkyl groups. As (optionally substituted), for example, [(5-tetrazolyl) methoxy] methyl group, [2- (5-tetrazolyl) ethoxy] methyl group, [3- (5-tetrazolyl) propoxy] methyl group, [ 2- (5-tetrazolyl) propoxy] methyl group, [4- (5-tetrazolyl) butoxy] methyl group, [5- (5-tetrazolyl) pe Toxi] methyl group, [4- (1-tetrazolyl) pentoxy] methyl group, [6- (5-tetrazolyl) hexyloxy] methyl group, 2-[(1-tetrazolyl) methoxy] ethyl group, 1- [2- (5-tetrazolyl) ethoxy] ethyl group, 3- [3- (1-tetrazolyl) propoxy] propyl group, 4- [2- (5-tetrazolyl) propoxy] butyl group, 5- [4- (1-tetrazolyl) Butoxy] hexyl, 1,1-dimethyl-2- [5- (5-tetrazolyl) pentoxy] ethyl, 2-methyl-3- [4- (1-tetrazolyl) pentoxy] propyl, 2- [6- (5-tetrazolyl) hexyloxy] ethyl group, {[1- (2-phenylethyl) -5-tetrazolyl] methoxy} methyl group, [(1-cyclohexylmethyl- -Tetrazolyl) methoxy] methyl group, [(5-benzyl-1-tetrazolyl) methoxy] methyl group, [(1-cyclopentylmethyl-5-tetrazolyl) methoxy] methyl group, {[5- (2-cyclohexylethyl)- 1-tetrazolyl] methoxy} methyl group, [(1-benzyl-5-tetrazolyl) methoxy] methyl group, [(1-cycloheptylmethyl-5-tetrazolyl) methoxy] methyl group, {[1- (3-phenylpropyl) ) -5-tetrazolyl] methoxy} methyl group, [(1-phenyl-5-tetrazolyl) methoxy] methyl group, {[1- (4-trifluoromethoxyphenyl) -5-tetrazolyl] methoxy} methyl group, {[ 1- (4-trifluoromethylphenyl) -5-tetrazolyl] methoxy} methyl group, {[1- (4 -Chlorophenyl) -5-tetrazolyl] methoxy} methyl group or the like tetrazolyl C1-6 alkoxy substituted C1-6 alkyl group (on the tetrazole ring, phenyl group (on the phenyl ring, halogen atom, halogen substituted or unsubstituted 1 to 6 groups selected from the group consisting of a linear or branched alkyl group having 1 to 6 carbon atoms and a halogen-substituted or unsubstituted linear or branched alkoxy group having 1 to 6 carbon atoms. A group selected from the group consisting of a phenyl C1-6 alkyl group and a C3-8 cycloalkyl C1-6 alkyl group may be substituted). Can be mentioned.

  As an isoxazolyl C1-6 alkoxy substituted C1-6 alkyl group (on the isoxazole ring, at least one C1-6 alkyl group may be substituted), for example, [(3-isoxazolyl) methoxy] methyl Group, [2- (4-isoxazolyl) ethoxy] methyl group, [3- (5-isoxazolyl) propoxy] methyl group, [2- (3-isoxazolyl) propoxy] methyl group, [4- (4-isoxazolyl) butoxy ] Methyl group, [5- (5-isoxazolyl) pentoxy] methyl group, [4- (3-isoxazolyl) pentoxy] methyl group, [6- (4-isoxazolyl) hexyloxy] methyl group, 2-[(5- Isoxazolyl) methoxy] ethyl group, 1- [2- (3-isoxazolyl) ethoxy] ethyl Group, 3- [3- (4-isoxazolyl) propoxy] propyl group, 4- [2- (5-isoxazolyl) propoxy] butyl group, 5- [4- (3-isoxazolyl) butoxy] hexyl group, 1,1 -Dimethyl-2- [5- (4-isoxazolyl) pentoxy] ethyl group, 2-methyl-3- [4- (5-isoxazolyl) pentoxy] propyl group, 2- [6- (3-isoxazolyl) hexyloxy] Ethyl group, [(5-methyl-3-isoxazolyl) methoxy] methyl group, [(4-ethyl-3-isoxazolyl) methoxy] methyl group, [(3-n-propyl-4-isoxazolyl) methoxy] methyl group, [(5-n-butyl-3-isoxazolyl) methoxy] methyl group, [(4-n-pentyl-3-isoxazolyl) Isoxazolyl C1-6 alkoxy-substituted C1-6 alkyl such as [toxi] methyl group, [(3-n-hexyl-5-isoxazolyl) methoxy] methyl group, [(4,5-dimethyl-3-isoxazolyl) methoxy] methyl group, etc. Group (on the isoxazole ring, 1 to 2 C1-6 alkyl groups may be substituted).

  A benzothienyl C1-6 alkoxy substituted C1-6 alkyl group (on the benzothiophene ring from the group consisting of a halogen atom, a halogen substituted or unsubstituted C1-6 alkyl group and a halogen substituted or unsubstituted C1-6 alkoxy group) Examples of the group which may be substituted with at least one selected group include [(3-benzothienyl) methoxy] methyl group, [2- (2-benzothienyl) ethoxy] methyl group, [3- (4-benzothienyl) propoxy] methyl group, [2- (5-benzothienyl) propoxy] methyl group, [4- (6-benzothienyl) butoxy] methyl group, [5- (7-benzothienyl) pentoxy] Methyl group, [4- (3-benzothienyl) pentoxy] methyl group, [6- (2-benzothienyl) hexyloxy] methyl group 2-[(4-benzothienyl) methoxy] ethyl group, 1- [2- (5-benzothienyl) ethoxy] ethyl group, 3- [3- (6-benzothienyl) propoxy] propyl group, 4- [2 -(7-benzothienyl) propoxy] butyl group, 5- [4- (3-benzothienyl) butoxy] hexyl group, 1,1-dimethyl-2- [5- (3-benzothienyl) pentoxy] ethyl group, 2-methyl-3- [4- (5-benzothienyl) pentoxy] propyl group, 2- [6- (3-benzothienyl) hexyloxy] ethyl group, [(5-methyl-3-benzothienyl) methoxy] Methyl group, [(4-ethyl-3-benzothienyl) methoxy] methyl group, [(5-chloro-3-benzothienyl) methoxy] methyl group, [(6-methyl-3-benzothienyl) Methoxy] methyl group, [(4-trifluoromethyl-3-benzothienyl) methoxy] methyl group, [(3-methoxy-5-benzothienyl) methoxy] methyl group, [(5-trifluoromethoxy-3-benzo Thienyl) methoxy] methyl group, [(4,5-dichloro-3-benzothienyl) methoxy] methyl group, [(2,4,5-trifluoro-3-benzothienyl) methoxy] methyl group, [(4 5-dichloro-2-methyl-3-benzothienyl) methoxy] methyl group, [(4,5-dichloro-2-methoxy-3-benzothienyl) methoxy] methyl group and the like benzothienyl C1-6 alkoxy substituted C1 6 alkyl group (on the benzothiophene ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or 1 to 3 groups selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted).

  1,3,4-oxadiazolyl C1-6 alkoxy-substituted C1-6 alkyl group (on 1,3,4-oxadiazole ring, phenyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted As the optionally substituted group may be substituted with at least one group selected from the group consisting of a C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. [(2-1,3,4-oxadiazolyl) methoxy] methyl group, [2- (2-1,3,4-oxadiazolyl) ethoxy] methyl group, [3- (2-1,3,4-oxadiazolyl) [Propoxy] methyl group, [2- (2-1,3,4-oxadiazolyl) propoxy] methyl group, [4- (2-1,3,4-oxadiazolyl) butoxy] methyl group, [5 (2-1,3,4-oxadiazolyl) pentoxy] methyl group, [4- (2-1,3,4-oxadiazolyl) pentoxy] methyl group, [6- (2-1,3,4-oxadiazolyl) hexyl Oxy] methyl group, 2-[(2-1,3,4-oxadiazolyl) methoxy] ethyl group, 1- [2- (2-1,3,4-oxadiazolyl) ethoxy] ethyl group, 3- [3- (2-1,3,4-oxadiazolyl) propoxy] propyl group, 4- [2- (2-1,3,4-oxadiazolyl) propoxy] butyl group, 5-[(2-1,3,4-oxadiazolyl) ) Methoxy] pentyl group, 6- [4- (2-1,3,4-oxadiazolyl) butoxy] hexyl group, 1,1-dimethyl-2- [5- (2-1,3,4-oxadiazolyl) pentoxy ] Til group, 2-methyl-3- [4- (2-1,3,4-oxadiazolyl) pentoxy] propyl group, 2- [6- (2-1,3,4-oxadiazolyl) hexyloxy] ethyl group, [5- (4-methylphenyl) -2-1,3,4-oxadiazolyl] methoxymethyl group, [5- (4-chlorophenyl) -2-1,3,4-oxadiazolyl] methoxymethyl group, [5- (4-trifluoromethylphenyl) -2-1,3,4-oxadiazolyl] methoxymethyl group, [5- (4-methoxyphenyl) -2-1,3,4-oxadiazolyl] methoxymethyl group, [5- (4-trifluoromethoxyphenyl) -2-1,3,4-oxadiazolyl] methoxymethyl group, [5- (2,4-dichlorophenyl) -2-1,3,4-oxadiazolyl Ru] methoxymethyl group, [5- (2,4,6-trimethylphenyl) -2-1,3,4-oxadiazolyl] methoxymethyl group, [5- (2,4-dimethoxyphenyl) -2-1, 1,3,4-oxadiazolyl C1-6 alkoxy-substituted C1-6 alkyl group such as 3,4-oxadiazolyl] methoxymethyl group (on 1,3,4-oxadiazole ring, phenyl group [on phenyl ring Is substituted with 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups. May be substituted).

  Examples of the C2-6 alkynyloxy-substituted C1-6 alkyl group include an ethynyloxymethyl group, a 2-ethynyloxymethyl group, a 2- (2-ethynyloxy) ethyl group, a 1- (2-butynyloxy) ethyl group, 2 -(3-butynyloxy) ethyl group, 3- (1-methyl-2-propynyloxy) propyl group, 4- (2-pentynyloxy) butyl group, 4- (2-hexynyloxy) butyl group, 5- (2 -Propynyloxy) pentyl group, 6- (2-propynyloxy) hexyl group, 6- (2-butynyloxy) hexyl group, 1,1-dimethyl-2- (2-propynyloxy) ethyl group, 2-methyl-3 -(2-propynyloxy) propyl group and the like can be mentioned.

  Examples of the naphthyl C1-6 alkoxy-substituted C1-6 alkyl group include (1-naphthyl) methoxymethyl group, [2- (2-naphthyl) ethoxy] methyl group, [3- (1-naphthyl) propoxy] methyl group. , [2- (2-naphthyl) propoxy] methyl group, [4- (1-naphthyl) butoxy] methyl group, [5- (2-naphthyl) pentoxy] methyl group, [4- (1-naphthyl) pentoxy] Methyl group, [6- (1-naphthyl) hexyloxy] methyl group, 2-[(1-naphthyl) methoxy] ethyl group, 1- [2- (2-naphthyl) ethoxy] ethyl group, 3- [3- (1-naphthyl) propoxy] propyl group, 4- [2- (2-naphthyl) propoxy] butyl group, 5- [4- (1-naphthyl) butoxy] pentyl group, 6- [5- (2-naphthyl) A pentoxy] hexyl group, a 1,1-dimethyl-2- [4- (1-naphthyl) pentoxy] ethyl group, a 2-methyl-3- [6- (1-naphthyl) hexyloxy] propyl group, and the like. it can.

  1,2,4-oxadiazolyl C1-6 alkoxy-substituted C1-6 alkyl group [on the 1,2,4-oxadiazole ring, a phenyl group may be substituted], for example, [(3 -1,2,4-oxadiazolyl) methoxy] methyl group, [2- (5-1,2,4-oxadiazolyl) ethoxy] methyl group, [3- (3-1,2,4-oxadiazolyl) propoxy] methyl Group, [2- (5-1,2,4-oxadiazolyl) propoxy] methyl group, [4- (3-1,2,4-oxadiazolyl) butoxy] methyl group, [5- (5-1,2, 4-oxadiazolyl) pentoxy] methyl group, [4- (3-1,2,4-oxadiazolyl) pentoxy] methyl group, [6- (3-1,2,4-oxadiazolyl) hexyloxy] methyl group, 2 [(5-1,2,4-oxadiazolyl) methoxy] ethyl group, 1- [2- (3-1,2,4-oxadiazolyl) ethoxy] ethyl group, 3- [3- (5-1,2, 4-oxadiazolyl) propoxy] propyl group, 4- [2- (3-1,2,4-oxadiazolyl) propoxy] butyl group, 5-[(3-1,2,4-oxadiazolyl) methoxy] pentyl group, 6 -[4- (5-1,2,4-oxadiazolyl) butoxy] hexyl group, 1,1-dimethyl-2- [5- (3-1,2,4-oxadiazolyl) pentoxy] ethyl group, 2-methyl -3- [4- (5-1,2,4-oxadiazolyl) pentoxy] propyl group, 2- [6- (3-1,2,4-oxadiazolyl) hexyloxy] ethyl group, (5-phenyl-3 -1,2,4 1,2,4-oxadiazolyl C1-6 alkoxy-substituted C1-6 alkyl groups such as (oxadiazolyl) methoxymethyl group, (3-phenyl-5-1,2,4-oxadiazolyl) methoxymethyl group [1,2,4- On the oxadiazole ring, a phenyl group may be substituted].

  Pyridyl C1-6 alkoxy-substituted C1-6 alkyl group [on the pyridine ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. The group may be substituted with at least one kind of group such as (2-pyridyl) methoxymethyl group, [2- (3-pyridyl) ethoxy] methyl group, [3- (4-pyridyl) propoxy ] Methyl group, [2- (2-pyridyl) propoxy] methyl group, [4- (3-pyridyl) butoxy] methyl group, [5- (4-pyridyl) pentoxy] methyl group, [4- (2-pyridyl) ) Pentoxy] methyl group, [6- (3-pyridyl) hexyloxy] methyl group, 2-[(4-pyridyl) methoxy] ethyl group, 1- [2- (2-pyridy) ) Ethoxy] ethyl group, 3- [3- (3-pyridyl) propoxy] propyl group, 4- [2- (4-pyridyl) propoxy] butyl group, 5-[(2-pyridyl) methoxy] pentyl group, 6 -[4- (2-pyridyl) butoxy] hexyl group, 1,1-dimethyl-2- [5- (3-pyridyl) pentoxy] ethyl group, 2-methyl-3- [4- (4-pyridyl) pentoxy ] Propyl group, 2- [6- (2-pyridyl) hexyloxy] ethyl group, (2-trifluoromethyl-5-pyridyl) methoxymethyl group, (4-chloro-2-pyridyl) methoxymethyl group, (3 -Trifluoromethyl-2-pyridyl) methoxymethyl group, (2-methoxy-4-pyridyl) methoxymethyl group, (2-trifluoromethoxy-5-pyridyl) methoxymethyl group, , 4-Dibromo-3-pyridyl) methoxymethyl group, (2,4,6-trimethyl-5-pyridyl) methoxymethyl group, (2,4-dimethoxy-5-pyridyl) methoxymethyl group, (2,4,4) 6-trifluoro-3-pyridyl) pyridyl C1-6 alkoxy-substituted C1-6 alkyl group such as methoxymethyl group [on the pyridine ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or 1 to 3 groups selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted].

  A thiazolyl C1-6 alkoxy-substituted C1-6 alkyl group [on the thiazole ring at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted And at least one group selected from the group consisting of substituted C1-6 alkoxy groups may be substituted) and at least one group selected from the group consisting of lower alkyl groups may be substituted. ], For example, (4-thiazolyl) methoxymethyl group, [2- (2-thiazolyl) ethoxy] methyl group, [3- (5-thiazolyl) propoxy] methyl group, [2- (4-thiazolyl) propoxy ] Methyl group, [4- (2-thiazolyl) butoxy] methyl group, [5- (4-thiazolyl) pentoxy] methyl group, [4- (5-thia Zolyl) pentoxy] methyl group, [6- (4-thiazolyl) hexyloxy] methyl group, 2-[(2-thiazolyl) methoxy] ethyl group, 1- [2- (5-thiazolyl) ethoxy] ethyl group, 3 -[3- (4-thiazolyl) propoxy] propyl group, 4- [2- (2-thiazolyl) propoxy] butyl group, 5-[(4-thiazolyl) methoxy] pentyl group, 6- [4- (5- Thiazolyl) butoxy] hexyl group, 1,1-dimethyl-2- [5- (4-thiazolyl) pentoxy] ethyl group, 2-methyl-3- [4- (2-thiazolyl) pentoxy] propyl group, 2- [ 6- (5-thiazolyl) hexyloxy] ethyl group, [2- (4-methylphenyl) -4-thiazolyl] methoxymethyl group, [2- (4-chlorophenyl) -4-thiazolyl Methoxymethyl group, [2- (4-trifluoromethylphenyl) -4-thiazolyl] methoxymethyl group, [5- (4-methoxyphenyl) -4-thiazolyl] methoxymethyl group, [2- (4-trifluoro Methoxyphenyl) -4-thiazolyl] methoxymethyl group, [5- (2,4-dichlorophenyl) -2-thiazolyl] methoxymethyl group, [4- (2,4,6-trimethylphenyl) -2-thiazolyl] methoxy Methyl group, [4- (2,4-dimethoxyphenyl) -2-thiazolyl] methoxymethyl group, (2-methyl-4-thiazolyl) methoxymethyl group, (2,5-dimethyl-5-thiazolyl) methoxymethyl group , (2-phenyl-4-methyl-5-thiazolyl) methoxymethyl group and the like thiazolyl C1-6 alkoxy substituted C1-6 al Kill group [on the thiazole ring, 1 to 2 phenyl groups (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted linear or branched alkyl group having 1 to 6 carbon atoms, and halogen substitution) Or 1 to 5 groups, preferably 1 to 3 groups selected from the group consisting of unsubstituted linear or branched alkoxy groups having 1 to 6 carbon atoms, and 1 carbon atom. 1 to 2 groups selected from the group consisting of ˜6 linear or branched alkyl groups may be substituted].

  1,2,3,4-tetrahydronaphthyl C1-6 alkoxy-substituted C1-6 alkyl group [on the 1,2,3,4-tetrahydronaphthalene ring, at least one C1-6 alkyl group is substituted. May be, for example, (6-1,2,3,4-tetrahydronaphthyl) methoxymethyl group, [2- (2-1,2,3,4-tetrahydronaphthyl) ethoxy] methyl group, [3 -(3-1,2,3,4-tetrahydronaphthyl) propoxy] methyl group, [2- (4-1,2,3,4-tetrahydronaphthyl) propoxy] methyl group, [4- (5-1, 2,3,4-tetrahydronaphthyl) butoxy] methyl group, [5- (6-1,2,3,4-tetrahydronaphthyl) pentoxy] methyl group, [4- (6-1,2,3,4) Tetrahydronaphthyl Pentoxy] methyl group, [6- (5-1,2,3,4-tetrahydronaphthyl) hexyloxy] methyl group, 2-[(6-1,2,3,4-tetrahydronaphthyl) methoxy] ethyl group, 1- [2- (6-1,2,3,4-tetrahydronaphthyl) ethoxy] ethyl group, 3- [3- (5-1,2,3,4-tetrahydronaphthyl) propoxy] propyl group, 4- [2- (5-1,2,3,4-tetrahydronaphthyl) propoxy] butyl group, 5- [4- (6-1,2,3,4-tetrahydronaphthyl) butoxy] pentyl group, 6- [5 -(5-1,2,3,4-tetrahydronaphthyl) pentoxy] hexyl group, 1,1-dimethyl-2- [4- (6-1,2,3,4-tetrahydronaphthyl) pentoxy] ethyl group, 2-Methyl-3- [6 (6-1,2,3,4-tetrahydronaphthyl) hexyloxy] propyl group, (1,1,4,4-tetramethyl-6-1,2,3,4-tetrahydronaphthyl) methoxymethyl group, 1,1,4-trimethyl-6-1,2,3,4-tetrahydronaphthyl) methoxymethyl group, (1,1-dimethyl-6-1,2,3,4-tetrahydronaphthyl) methoxymethyl group, 1,1-dimethyl-7-1,2,3,4-tetrahydronaphthyl) methoxymethyl group, (1-methyl-6-1,2,3,4-tetrahydronaphthyl) methoxymethyl group, (1,4- Dimethyl-6-1,2,3,4-tetrahydronaphthyl) methoxymethyl group, (1,1,4,4-tetraethyl-6-1,2,3,4-tetrahydronaphthyl) methoxymethyl group, 1- Dimethyl-4-ethyl-6-1,2,3,4-tetrahydronaphthyl) methoxymethyl group, (1,1-di-n-propyl-6-1,2,3,4-tetrahydronaphthyl) methoxymethyl group , (4,4-di-n-butyl-6-1,2,3,4-tetrahydronaphthyl) methoxymethyl group, (1-n-pentyl-6-1,2,3,4-tetrahydronaphthyl) methoxy Methyl group, (1,4-di-n-hexyl-6-1,2,3,4-tetrahydronaphthyl) methoxymethyl group, (1-methyl-5-n-propyl-4-ethyl-6-1, 1,2,3,4-tetrahydronaphthyl) methoxymethyl group and the like 1,2,3,4-tetrahydronaphthyl C1-6 alkoxy substituted C1-6 alkyl group [on the 1,2,3,4-tetrahydronaphthalene ring, 1 to 4 Serial C1~6 alkyl group can be exemplified] may be substituted.

  Carbamoyl C1-6 alkoxy-substituted C1-6 alkyl group [on the amino group a C3-8 cycloalkyl group and a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen At least one group selected from the group consisting of a group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted)] As, for example, carbamoylmethoxymethyl group, 2- (carbamoylethoxy) methyl group, (3-carbamoylpropoxy) methyl group, (2-carbamoylpropoxy) methyl group, (4-carbamoylbutoxy) methyl group, (5-carbamoyl) Pentoxy) methyl group, (4-carbamoylpentoxy) methyl group, (6-carbamoyl) Xyloxy) methyl group, 2- (carbamoylmethoxy) ethyl group, 1- (2-carbamoylethoxy) ethyl group, 3- (3-carbamoylpropoxy) propyl group, 4- (2-carbamoylpropoxy) butyl group, 5- ( Carbamoylmethoxy) pentyl group, 4- (2-carbamoylpropoxy) butyl group, 6- (4-carbamoylbutoxy) hexyl group, 1,1-dimethyl-2- (5-carbamoylpentoxy) ethyl group, 2-methyl- 3- (4-carbamoylpentoxy) propyl group, 2- (6-carbamoylhexyloxy) ethyl group, [N- (4-methylphenyl) carbamoyl] methoxymethyl group, [N- (4-chlorophenyl) carbamoyl] methoxy Methyl group, [N- (4-trifluoromethylphenyl) carbamoyl] Toximethyl group, [N- (4-methoxyphenyl) carbamoyl] methoxymethyl group, [N- (4-trifluoromethoxyphenyl) carbamoyl] methoxymethyl group, [N- (2,4-dichlorophenyl) carbamoyl] methoxymethyl group , [N- (2,4,6-trimethylphenyl) carbamoyl] methoxymethyl group, [N- (2,4-dimethoxyphenyl) carbamoyl] methoxymethyl group, (N-cyclohexylcarbamoyl) methoxymethyl group, Cyclopentylcarbamoyl) methoxymethyl group, (N-cycloheptylcarbamoyl) methoxymethyl group, (N-cyclooctylcarbamoyl) methoxymethyl group, (N-cyclobutylcarbamoyl) methoxymethyl group, (N-cyclopropylcarbamoyl) methoxymethyl group , (N-cyclopropyl-N-cyclohexylcarbamoyl) methoxymethyl group, (N, N-dicyclohexylcarbamoyl) methoxymethyl group, [N-cyclopropyl-N- (4-fluoromethylphenyl) carbamoyl] methoxymethyl group, N-cyclohexyl-N- (4-fluoromethylphenyl) carbamoyl] carbamoyl C1-6 alkoxy substituted C1-6 alkyl group such as methoxymethyl group (on the amino group, C3-8 cycloalkyl group and phenyl group [phenyl ring Above, 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group 1 to 2 groups selected from the group consisting of [which may be substituted] May be) can be mentioned.

  Examples of the benzofuryl C1-6 alkoxy-substituted C1-6 alkyl group [at least one cyano group may be substituted on the benzofuran ring] include (2-benzofuryl) methoxymethyl group, [2- ( 3-benzofuryl) ethoxy] methyl group, [3- (4-benzofuryl) propoxy] methyl group, [2- (5-benzofuryl) propoxy] methyl group, [4- (6-benzofuryl) butoxy] methyl group, [5 -(7-benzofuryl) pentoxy] methyl group, [4- (2-benzofuryl) pentoxy] methyl group, [6- (3-benzofuryl) hexyloxy] methyl group, 2-[(2-benzofuryl) methoxy] ethyl group 1- [2- (3-benzofuryl) ethoxy] ethyl group, 3- [3- (4-benzofuryl) propoxy] propyl group, 4 [2- (5-benzofuryl) propoxy] butyl group, 5- [4- (6-benzofuryl) butoxy] pentyl group, 6- [5- (7-benzofuryl) pentoxy] hexyl group, 1,1-dimethyl-2 -[4- (2-benzofuryl) pentoxy] ethyl group, 2-methyl-3- [6- (3-benzofuryl) hexyloxy] propyl group, (7-cyano-2-benzofuryl) methoxymethyl group, (6- (Cyano-2-benzofuryl) methoxymethyl group, (5-cyano-2-benzofuryl) methoxymethyl group, (4-cyano-2-benzofuryl) methoxymethyl group, (3-cyano-2-benzofuryl) methoxymethyl group, 2-cyano-5-benzofuryl) methoxymethyl group, (6,7-dicyano-2-benzofuryl) methoxymethyl group, (3,4,5- Rishiano 2- benzofuryl) [On benzofuran ring, may be substituted by one to three cyano groups] benzofuryl C1~6 alkoxy substituent C1~6 alkyl group such as a methoxymethyl group and the like.

  Examples of the C7-10 alkoxy group include n-heptyloxy group, n-octyloxy group, n-nonyloxy group, n-decyloxy group, 5-methylhexyloxy group, 4,4-dimethylpentyloxy group, 6- A methyl heptyloxy group, a 5,5,5-trimethylpentyloxy group, etc. can be mentioned.

  Phenoxy group [on the phenyl ring, at least one group selected from the group consisting of a phenyl C1-6 alkoxy group, a C3-8 cycloalkyl group, a C7-10 alkoxy group, and a phenoxy group is substituted. ], For example, 4-benzyloxyphenoxy group, 4-cyclohexylphenoxy group, 4-n-octyloxyphenoxy group, 4-cyclopentylphenoxy group, 3-phenoxyphenoxy group, 3-benzyloxyphenoxy group, 3-cyclohexyl Phenoxy group, 3-n-octyloxyphenoxy group, 3-cyclopentylphenoxy group, 4-phenoxyphenoxy group, 2-benzyloxyphenoxy group, 2-cyclohexylphenoxy group, 2-n-heptyloxyphenoxy group, 2-cyclopentylphenoxy group Group, 2-Fe Xyphenoxy group, 4- (2-phenylethoxy) phenoxy group, 4-cyclooctylphenoxy group, 4-n-nonyloxyphenoxy group, 4-cyclopropylphenoxy group, 2,3-diphenoxyphenoxy group, 4- ( 3-phenylpropoxy) phenoxy group, 4-cycloheptylphenoxy group, 4-n-decyloxyphenoxy group, 4-cyclobutylphenoxy group, 2,4,6-triphenoxyphenoxy group, 4- (4-phenylbutoxy) Phenoxy group, 2,4-dicyclohexylphenoxy group, 2,4-di-n-octyloxyphenoxy group, 2,4,6-tricyclopentylphenoxy group, 3-phenoxy-4-benzyloxyphenoxy group, 4- (5 -Phenylpentyloxy) phenoxy group, 4-cyclohexyl-3-fe Xyphenoxy group, 2,4,6-tri-n-octyloxyphenoxy group, 4-cyclopentyl-2-benzyloxyphenoxy group, 3-phenoxy-2-cyclohexylphenoxy group, 4- (6-phenylhexoxy) Phenoxy groups such as phenoxy group, 3,4,5-tribenzyloxyphenoxy group, 2,4-dibenzyloxyphenoxy group [on the phenyl ring, phenyl C1-6 alkoxy group, C3-8 cycloalkyl group, C7 To 1 to 3 groups selected from the group consisting of 10 to 10 alkoxy groups and phenoxy groups.

  Examples of the 2,3-dihydrobenzofuryloxy group [at least one oxo group may be substituted on the 2,3-dihydrobenzofuran ring] include (2-, 3-, 4-, 5-, 6- or 7-) 2,3-dihydrobenzofuryloxy group, 3-oxo-6-2,3-dihydrobenzofuryloxy group, 2-oxo-5-2,3-dihydrobenzofuryloxy group 2,3-dihydrobenzofuryloxy groups such as 1 to 2 oxo groups may be substituted on the 2,3-dihydrobenzofuran ring.

  Examples of the benzothiazolyloxy group [at least one C1-6 alkyl group may be substituted on the benzothiazole ring] include (2-, 4-, 5-, 6- or 7). -) Benzothiazolyloxy group, 2-methyl-5-benzothiazolyloxy group, 2-ethyl-5-benzothiazolyloxy group, 2-n-propyl-5-benzothiazolyloxy group, 2-tert-butyl-5-benzothiazolyloxy group, 2-n-pentyl-5-benzothiazolyloxy group, 2-n-hexyl-5-benzothiazolyloxy group, 2,5-dimethyl Benzothiazolyloxy group such as -6-benzothiazolyloxy group, 4,5,6-trimethyl-2-benzothiazolyloxy group [1-3 C1-6 alkyl on benzothiazole ring Group may be substituted ] Can be mentioned.

  Examples of the furyl C1-6 alkoxy group [at least one C1-6 alkoxycarbonyl group may be substituted on the furan ring] include (2- or 3-) furylmethoxy group, 2- [ (2- or 3-) furyl] ethoxy group, 1-[(2- or 3-) furyl] ethoxy group, 3-[(2- or 3-) furyl] propoxy group, 2-[(2- or 3 -) Furyl] propoxy group, 4-[(2- or 3-) furyl] butoxy group, 5-[(2- or 3-) furyl] pentoxy group, 4-[(2- or 3-) furyl] pentoxy group Group, 6-[(2- or 3-) furyl] hexyloxy group, 2-methyl-3-[(2- or 3-) furyl] propoxy group, 1,1-dimethyl-2-[(2- or 3-) furyl] ethoxy group, 2-ethoxycarbonyl-5-furylme Xoxy group, 2-ethoxycarbonyl-5-furylmethoxy group, 2-methoxycarbonyl-4-furylmethoxy group, 2-propoxycarbonyl-3-furylmethoxy group, 2-butoxycarbonyl-5-furylmethoxy group, 2-pentyl Oxycarbonyl-5-furylmethoxy group, 2-hexyloxycarbonyl-5-furylmethoxy group, 2,3-diethoxycarbonyl-5-furylmethoxy group, 2,3,4-trimethoxycarbonyl-5-furylmethoxy group And a furyl C1-6 alkoxy group such as 1 to 3 C1-6 alkoxycarbonyl groups may be substituted on the furan ring.

  Tetrazolyl C1-6 alkoxy group [on the tetrazole ring, at least one group selected from the group consisting of phenyl C1-6 alkyl group and C3-8 cycloalkyl C1-6 alkyl group may be substituted] Are, for example, (1-, 2- or 5-) tetrazolylmethoxy group, 2-[(1-, 2- or 5-) tetrazolyl] ethoxy group, 1-[(1-, 2- or 5- ) Tetrazolyl] ethoxy group, 3-[(1-, 2- or 5-) tetrazolyl] propoxy group, 2-[((1-, 2- or 5-) tetrazolyl) propoxy group, 4-[(1-, 2- or 5-) tetrazolyl] butoxy group, 5-[(1-, 2- or 5-) tetrazolyl] pentoxy group, 4-[(1-, 2- or 5-) tetrazolyl] pentoxy group, 6- [ (1-, 2- or 5-) Lazolyl] hexyloxy group, 2-methyl-3-[(1-, 2- or 5-) tetrazolyl] propoxy group, 1,1-dimethyl-2-[(1-, 2- or 5-) tetrazolyl] ethoxy Group, 1- (2-phenylethyl) -5-tetrazolylmethoxy group, 1-cyclohexylmethyl-5-tetrazolylmethoxy group, 5-benzyl-1-tetrazolylmethoxy group, 5- (2-cyclopentyl) Ethyl) -1-tetrazolylmethoxy group, 1-benzyl-5-tetrazolylmethoxy group, 1- (3-phenylpropyl) -5-tetrazolylmethoxy group, 1- (4-phenylbutyl) -5 -Tetrazolylmethoxy group, 1- (5-phenylpentyl) -5-tetrazolylmethoxy group, 1- (6-phenylhexyl) -5-tetrazolylmethoxy group, 1-cyclo Tylmethyl-5-tetrazolylmethoxy group, 1- (3-cyclopropylpropyl) -5-tetrazolylmethoxy group, 1- (4-cycloheptylbutyl) -5-tetrazolylmethoxy group, 1- (5 -Cyclooctyl rupentyl) -5-tetrazolylmethoxy group, 1- (6-cyclohexylhexyl) -5-tetrazolylmethoxy group and other tetrazolyl C1-6 alkoxy groups [on the tetrazole ring, phenyl C1-6 A group selected from the group consisting of an alkyl group and a C3-8 cycloalkyl C1-6 alkyl group may be substituted].

  1,2,4-oxadiazolyl C1-6 alkoxy group [on the 1,2,4-oxadiazole ring, phenyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group And at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted)] is, for example, (3- or 5 -) 1,2,4-oxadiazolyrylmethoxy group, 2-[(3- or 5-) 1,2,4-oxadiazolyl] ethoxy group, 1-[(3- or 5-) 1,2,4 -Oxadiazolyl] ethoxy group, 3-[(3- or 5-) 1,2,4-oxadiazolyl] propoxy group, 2-[(3- or 5-) 1,2,4-oxadiazolyl] propoxy group, 4- [(3- or -) 1,2,4-oxadiazolyl] butoxy group, 5-[(3- or 5-) 1,2,4-oxadiazolyl] pentoxy group, 4-[(3- or 5-) 1,2,4- Oxadiazolyl] pentoxy group, 6-[(3- or 5-) 1,2,4-oxadiazolyl] hexyloxy group, 2-methyl-3-[(3- or 5-) 1,2,4-oxadiazolyl] propoxy Group, 1,1-dimethyl-2-[(3- or 5-) 1,2,4-oxadiazolyl] ethoxy group, 3- (4-tert-butylphenyl) -5-1,2,4-oxadiazo Rylmethoxy group, 3-phenyl-5-1,2,4-oxadiazolylmethoxy group, 3- (4-chlorophenyl) -5-1,2,4-oxadiazolylmethoxy group, 3- (4-tri Fluoromethylphenyl) -5 , 2,4-oxadiazolylmethoxy group, 5- (4-trifluoromethoxyphenyl) -3-1,2,4-oxadiazolylmethoxy group, 5- (4-methoxyphenyl) -3-1,2 , 4-oxadiazolylmethoxy group, 5- (2,4-dimethylphenyl) -3-1,2,4-oxadiazolylmethoxy group, 3- (2,4,6-trimethylphenyl) -5-1 , 2,4-oxadiazolylmethoxy group, 3- (2,4-dimethylphenyl) -5-1,2,4-oxadiazolylmethoxy group, 5- (2,4,6-trimethoxyphenyl)- 3-1,2,4-oxadiazolylmethoxy group, 3- (2,4-dibromophenyl) -5-1,2,4-oxadiazolylmethoxy group, 3- (2,4,6-trifluoro Phenyl) -5-1,2,4-oxa Diazolylmethoxy group, 3- (3,5-dichlorophenyl) -5-1,2,4-oxadiazolylmethoxy group, 3- (2-methyl-5-chlorophenyl) -5-1,2,4-oxa Diazolylmethoxy group, 3- (3-methoxy-5-chlorophenyl) -5-1,2,4-oxadiazolylmethoxy group, 3- (2,3,4,5,6-pentafluorophenyl) -5 1,2,4-oxadiazolylmethoxy group such as 1,2,4-oxadiazolylmethoxy group [on the 1,2,4-oxadiazole ring, phenyl group (on the phenyl ring, 1 to 5, preferably 1 to 3 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group are substituted. The Good) can be mentioned] may be substituted.

  Examples of the benzothienyl C1-6 alkoxy group [at least one halogen atom may be substituted on the benzothiophene ring] include, for example, (2-, 3-, 4-, 5-, 6- or 7-) benzothienylmethoxy group, 2-[(2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] ethoxy group, 1-[(2-, 3-, 4-, 5) -, 6- or 7-) benzothienyl] ethoxy group, 3-[(2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] propoxy group, 2-[(2-, 3 -, 4-, 5-, 6- or 7-) benzothienyl] propoxy group, 4-[(2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] butoxy group, 5- [(2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] pentoxy group, 4-[(2-, 3-, -, 5-, 6- or 7-) benzothienyl] pentoxy group, 6-[(2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] hexyloxy group, 2-methyl- 3-[(2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] propoxy group, 1,1-dimethyl-2-[(2-, 3-, 4-, 5-, 6- or 7-) benzothienyl] ethoxy group, 5-chloro-3-benzothienylmethoxy group, 4-bromo-2-benzothienylmethoxy group, 6-fluoro-5-benzothienylmethoxy group, 7-iodo-4 Benzothienyl C1-6 alkoxy groups such as -1,2,4-oxadiazolylmethoxy group, 4,5-dichloro-3-benzothienylmethoxy group, 3,4,5-trifluoro-2-benzothienylmethoxy group [On the benzothiophene ring 1 to 3 halogen atoms can be mentioned] may be substituted.

  Examples of the isoxazolyl C1-6 alkoxy group [at least one C1-6 alkyl group may be substituted on the isoxazole ring] include, for example, (3-, 4- or 5-) isoxazolyl Methoxy group, 2-[(3-, 4- or 5-) isoxazolyl] ethoxy group, 1-[(3-, 4- or 5-) isoxazolyl] ethoxy group, 3-[(3-, 4- or 5 -) Isoxazolyl] propoxy group, 2-[(3-, 4- or 5-) isoxazolyl] propoxy group, 4-[(3-, 4- or 5-) isoxazolyl] butoxy group, 5-[(3-, 4- or 5-) isoxazolyl] pentoxy group, 4-[(3-, 4- or 5-) isoxazolyl] pentoxy group, 6-[(3-, 4- or 5-) isoxazolyl] hexyloxy group, -Methyl-3-[(3-, 4- or 5-) isoxazolyl] propoxy group, 1,1-dimethyl-2-[(3-, 4- or 5-) isoxazolyl] ethoxy group, (3,5- (Dimethyl-4-isoxazolyl) methoxy group, (3-methyl-5-isoxazolyl) methoxy group, (4-ethyl-5-isoxazolyl) methoxy group, (5-n-propyl-4-isoxazolyl) methoxy group, (3- tert-butyl-4-isoxazolyl) methoxy group, (4-n-pentyl-5-isoxazolyl) methoxy group, (5-n-hexyl-5-isoxazolyl) methoxy group and the like isoxazolyl C 1-6 alkoxy group [isoxazole ring Above, 1 to 2 C1-6 alkyl groups may be substituted].

  1,3,4-oxadiazolyl C1-6 alkoxy group [At least one phenyl group on the 1,3,4-oxadiazole ring (at least one C1-6 alkyl group on the phenyl ring As (optionally substituted) may be substituted], for example, a 2-1,3,4-oxadiazolylmethoxy group, a 2- (2-1,3,4-oxadiazolyl) ethoxy group, 1- (2-1,3,4-oxadiazolyl) ethoxy group, 3- (2-1,3,4-oxadiazolyl) propoxy group, 2- (2-1,3,4-oxadiazolyl) propoxy group, 4- (2-1,3,4-oxadiazolyl) butoxy group, 5- (2-1,3,4-oxadiazolyl) pentoxy group, 4- (2-1,3,4-oxadiazolyl) pentoxy group, 6- (2 -1,3,4 Oxadiazolyl) hexyloxy group, 2-methyl-3- (2-1,3,4-oxadiazolyl) propoxy group, 1,1-dimethyl-2- (2-1,3,4-oxadiazolyl) ethoxy group, 2- (4-methylphenyl) -5-1,3,4-oxadiazolylmethoxy group, 3-phenyl-5-1,3,4-oxadiazolylmethoxy group, 2- (4-ethylphenyl) -5 1,3,4-oxadiazolylmethoxy group, 3- (4-n-propylphenyl) -5-1,3,4-oxadiazolylmethoxy group, 3- (4-sec-butylphenyl) -5 1,3,4-oxadiazolylmethoxy group, 3- (4-n-pentylphenyl) -5-1,3,4-oxadiazolylmethoxy group, 3- (2,4-dimethylphenyl) -5 1,3,4-Oki Diazolylmethoxy group, 3- (2,4,6-trimethylphenyl) -5-1,3,4-oxadiazolylmethoxy group, 3- (3-n-hexylphenyl) -5-1,3,4 -Oxadiazolylmethoxy group, 3- (2-methylphenyl) -5-1,3,4-oxadiazolylmethoxy group, 3- (3-methylphenyl) -5-1,2,4-oxadiazolyl 1,3,4-oxadiazolyl C1-6 alkoxy group such as methoxy group [on the 1,3,4-oxadiazole ring, one phenyl group (on the phenyl ring, 1 to 3 C1-6 6 alkyl group may be substituted) may be substituted].

  Examples of the naphthyl C1-6 alkoxy group include (2- or 3-) naphthylmethoxy group, 2-[(2- or 3-) naphthyl] ethoxy group, and 1-[(2- or 3-) naphthyl] ethoxy. Group, 3-[(2- or 3-) naphthyl] propoxy group, 2-[(2- or 3-) naphthyl] propoxy group, 4- (2- or 3-) naphthyl] butoxy group, 5-[( 2- or 3-) naphthyl] pentoxy group, 4- (1- or 2-) naphthyl] pentoxy group, 6- (2- or 3-) naphthyl] hexyloxy group, 2-methyl-3-[(2- Or 3-) naphthyl] propoxy group, 1,1-dimethyl-2-[(2- or 3-) naphthyl] ethoxy group, and the like.

  Examples of the pyridyl C1-6 alkoxy group (at least one halogen-substituted or unsubstituted C1-6 alkyl group may be substituted on the pyridine ring) include (1-, 2-, 3- Or 4-) pyridylmethoxy group, 2-[(1-, 2-, 3- or 4-) pyridyl] ethoxy group, 1-[(1-, 2-, 3- or 4-) pyridyl] ethoxy group, 3-[(1-, 2-, 3- or 4-) pyridyl] propoxy group, 2-[(1-, 2-, 3- or 4-) pyridyl] propoxy group, 4-[(1--2 -, 3- or 4-) pyridyl] butoxy group, 5- [1-, 2-, 3- or 4-] pyridyl] pentoxy group, 4-[(1-, 2-, 3- or 4-) pyridyl group ] Pentoxy group, 6-[(1-, 2-, 3- or 4-) pyridyl] hexyloxy group, 2-methyl -3-[(1-, 2-, 3- or 4-) pyridyl] propoxy group, 1,1-dimethyl-2-[(1-, 2-, 3- or 4-) pyridyl] ethoxy group, 2 -Trifluoromethyl-5-pyridylmethoxy group, 2-methyl-5-pyridylmethoxy group, 2-ethyl-6-pyridylmethoxy group, 3-n-propyl-2-pyridylmethoxy group, 4-n-butyl-5 -Pyridylmethoxy group, 3-n-pentyl-4-pyridylmethoxy group, 2-n-hexyl-6-pyridylmethoxy group, 2,3-ditrifluoromethyl-5-pyridylmethoxy group, 3,4,5-tri Pyridyl C1-6 alkoxy groups such as fluoromethyl-2-pyridylmethoxy group, 2,4-dimethyl-5-pyridylmethoxy group, 3,4,5-trimethyl-2-pyridylmethoxy group (on the pyridine ring) May 1-3 C1~6 alkyl groups halogen-substituted or unsubstituted of substituted) can be exemplified.

  A thiazolyl C1-6 alkoxy group [on the thiazole ring, at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 The group may be substituted with at least one group selected from the group consisting of alkoxy groups]. For example, (2-, 4- or 5-) thiazolylmethoxy group , 2-[(2-, 4- or 5-) thiazolyl] ethoxy group, 1-[(2-, 4- or 5-) thiazolyl] ethoxy group, 3-[(2-, 4- or 5-) Thiazolyl] propoxy group, 2-[(2-, 4- or 5-) thiazolyl] propoxy group, 4-[(2-, 4- or 5-) thiazolyl] butoxy group, 5-[(2-, 4- Or 5-) thiazolyl] pent Si group, 4-[(2-, 4- or 5-) thiazolyl] pentoxy group, 6-[(2-, 4- or 5-) thiazolyl] hexyloxy group, 2-methyl-3-[(2- , 4- or 5-) thiazolyl] propoxy group, 1,1-dimethyl-2-[(2-, 4- or 5-) thiazolyl] ethoxy group, 2- (4-trifluoromethylphenyl) -4-thia Zolylmethoxy group, 2-phenyl-4-thiazolylmethoxy group, 2- (4-chlorophenyl) -4-thiazolylmethoxy group, 2- (4-trifluoromethylphenyl) -5-thiazolylmethoxy Group, 2- (4-trifluoromethoxyphenyl) -4-thiazolylmethoxy group, 5- (4-methoxyphenyl) -3-thiazolylmethoxy group, 5- (2,4-dimethylphenyl) -2 -Thiazolylmethoxy group, -(2,4,6-trimethylphenyl) -2-thiazolylmethoxy group, 2- (2,4-dimethylphenyl) -5-thiazolylmethoxy group, 2- (2,4,6-trimethoxy Phenyl) -4-thiazolylmethoxy group, 2- (2,4-dibromophenyl) -4-thiazolylmethoxy group, 2- (2,4,6-trifluorophenyl) -5-thiazolylmethoxy group Group, 2- (3,5-dichlorophenyl) -4-thiazolylmethoxy group, 2- (2-methyl-5-chlorophenyl) -4-thiazolylmethoxy group, 2- (3-methoxy-5-chlorophenyl) ) -4-thiazolylmethoxy group, 2- (2,3,4,5,6-pentafluorophenyl) -4-thiazolylmethoxy group, 2,5-diphenyl-4-thiazolylmethoxy group, etc. Thiazolyl C1-6 Alky [1 to 2 phenyl groups on the thiazole ring (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] 1 to 5, preferably 1 to 3 groups selected from the group may be substituted].

  As a 1,2,3,4-tetrahydronaphthyl C1-6 alkoxy group (at least one C1-6 alkyl group may be substituted on the 1,2,3,4-tetrahydronaphthalene ring). For example, (1-, 2-, 5- or 6-) 1,2,3,4-tetrahydronaphthylmethoxy group, 2-[(1-, 2-, 5- or 6-) 1,2,3 , 4-Tetrahydronaphthyl] ethoxy group, 1-[(1-, 2, -5 or 6), 1,2,3,4-tetrahydronaphthyl] ethoxy group, 3-[(1-, 2, -5) -Or 6-) 1,2,3,4-tetrahydronaphthyl] propoxy group, 2-[(1-, 2, -5- or 6-) 1,2,3,4-tetrahydronaphthyl] propoxy group, 4 -[(1- or 2-) 1,2,3,4-tetrahydronaphthyl] butoxy group, -[(1- or 2-) 1,2,3,4-tetrahydronaphthyl] pentoxy group, 4-[(1-, 2, -5- or 6-) 1,2,3,4-tetrahydronaphthyl] Pentoxy group, 6-[(1-, 2, -5 or 6), 1,2,3,4-tetrahydronaphthyl] hexyloxy group, 2-methyl-3-[(1-, 2, -5- Or 6) 1,2,3,4-tetrahydronaphthyl] propoxy group, 1,1-dimethyl-2-[(1-, 2, -5 or 6)) 1,2,3,4-tetrahydronaphthyl ] Ethoxy group, (1,1,4,4-tetramethyl-6-1,2,3,4-tetrahydronaphthyl) methoxy group, (1,1,4-trimethyl-6-1,2,3,4) -Tetrahydronaphthyl) methoxy group, (1,1-dimethyl-6-1,2,3,4-tetrahydride) Naphthyl) methoxy group, (4,4-dimethyl-6-1,2,3,4-tetrahydronaphthyl) methoxy group, (1-methyl-6-1,2,3,4-tetrahydronaphthyl) methoxy group, 1,4-dimethyl-6-1,2,3,4-tetrahydronaphthyl) methoxy group, (1,1,4,4-tetraethyl-6-1,2,3,4-tetrahydronaphthyl) methoxy group, 1,1-dimethyl-4-ethyl-6-1,2,3,4-tetrahydronaphthyl) methoxy group, (1,1-di-n-propyl-6-1,2,3,4-tetrahydronaphthyl) methoxy Group, (4,4-di-n-butyl-6-1,2,3,4-tetrahydronaphthyl) methoxy group, (1-n-pentyl-6-1,2,3,4-tetrahydronaphthyl) methoxy The group (1,4-di-n-hexyl Ru-6-1,2,3,4-tetrahydronaphthyl) methoxy group, (1-methyl-5-n-propyl-4-ethyl-6-1,2,3,4-tetrahydronaphthyl) methoxy group and the like 1 , 2,3,4-Tetrahydronaphthyl C1-6 alkoxy group (on the 1,2,3,4-tetrahydronaphthalene ring, 1 to 4 C1-6 alkyl groups may be substituted). be able to.

  A phenoxy C1-6 alkoxy group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; As the species may be substituted, for example, phenoxymethoxy group, 2-phenoxyethoxy group, 1-phenoxyethoxy group, 3-phenoxypropoxy group, 2-phenoxypropoxy group, 4-phenoxybutoxy group, 5- Phenoxypentoxy group, 4-phenoxypentoxy group, 6-phenoxyhexyloxy group, 2-methyl-3-phenoxypropoxy group, 1,1-dimethyl-2-phenoxyethoxy group, 2-fluorophenoxymethoxy group, 3- Fluorophenoxymethoxy group, 4-fluorophenoxymethoxy Group, 2- (2-fluorophenoxy) ethoxy group, 2- (3-fluorophenoxy) ethoxy group, 2- (4-fluorophenoxy) ethoxy group, 2-chlorophenoxymethoxy group, 3-chlorophenoxymethoxy group, 4 -Chlorophenoxymethoxy group, 2-fluoro-4-bromophenoxymethoxy group, 4-chloro-3-fluorophenoxymethoxy group, 2-chloro-4-fluorophenoxymethoxy group, 3,4-dichlorophenoxymethoxy group, 3, 5-dichlorophenoxymethoxy group, 2,3-dichlorophenoxymethoxy group, 2,5-dichlorophenoxymethoxy group, 2,3,4-trichlorophenoxymethoxy group, 3,4,5-trifluorophenoxymethoxy group, 2, 3,4,5,6-pentafluorophenoxymethoxy group, 2 4,6-trichlorophenoxymethoxy group, 4-isopropylphenoxymethoxy group, 4-n-butylphenoxymethoxy group, 4-methylphenoxymethoxy group, 2-methylphenoxymethoxy group, 3-methylphenoxymethoxy group, 2,4- Dimethylphenoxymethoxy group, 2,3-dimethylphenoxymethoxy group, 2,6-dimethylphenoxymethoxy group, 3,5-dimethylphenoxymethoxy group, 2,5-dimethylphenoxymethoxy group, 2,4,6-trimethylphenoxymethoxy Group, 4-ethylphenoxymethoxy group, 4-isopropylphenoxymethoxy group, 3,5-ditrifluoromethylphenoxymethoxy group, 4-isopropoxyphenoxymethoxy group, 4-n-butoxyphenoxymethoxy group, 4-methoxyphenoxyme Toxi group, 2-methoxyphenoxymethoxy group, 3-methoxyphenoxymethoxy group, 2,4-dimethoxyphenoxymethoxy group, 2,3-dimethoxyphenoxymethoxy group, 2,6-dimethoxyphenoxymethoxy group, 3,5-dimethoxyphenoxy Methoxy group, 2,5-dimethoxyphenoxymethoxy group, 2,4,6-trimethoxyphenoxymethoxy group, 3,5-ditrifluoromethoxyphenoxymethoxy group, 2-isopropoxyphenoxymethoxy group, 3-chloro-4-methoxy Phenoxymethoxy group, 2-chloro-4-trifluoromethoxyphenoxymethoxy group, 3-methyl-4-fluorophenoxymethoxy group, 4-bromo-3-trifluoromethylphenoxymethoxy group, 2- (2-chlorophenoxy) ethoxy Group, 2- 3-chlorophenoxy) ethoxy group, 2- (4-chlorophenoxy) ethoxy group, 2-trifluoromethylphenoxymethoxy group, 3-trifluoromethylphenoxymethoxy group, 4-trifluoromethylphenoxymethoxy group, 2-trifluoro Methoxyphenoxymethoxy group, 3-trifluoromethoxyphenoxymethoxy group, 4-trifluoromethoxyphenoxymethoxy group, 2- (2-trifluoromethylphenoxy) ethoxy group, 2- (3-trifluoromethylphenoxy) ethoxy group, 2 -(4-trifluoromethylphenoxy) ethoxy group, 2- (2-trifluoromethoxyphenoxy) ethoxy group, 2- (3-trifluoromethoxyphenoxy) ethoxy group, 2- (4-trifluoromethoxyphenoxy) ethoxy group 3 (2-trifluoromethylphenoxy) propoxy group, 3- (3-trifluoromethylphenoxy) propoxy group, 3- (4-trifluoromethylphenoxy) propoxy group, 3- (2-trifluoromethylphenoxy) propoxy group, 3- (3-trifluoromethoxyphenoxy) propoxy group, 3- (4-trifluoromethoxyphenoxy) propoxy group, 4- (3-trifluoromethylphenoxy) butoxy group, 5- (4-trifluoromethylphenoxy) pentoxy group Group, 4- (4-trifluoromethylphenoxy) pentoxy group, 4- (4-trifluoromethoxyphenoxy) pentoxy group, 6- (3-trifluoromethylphenoxy) hexyloxy group, 6- (4-trifluoromethyl) Phenoxy) hexyloxy group, 6- (4- A phenoxy C1-6 alkoxy group such as a trifluoromethoxyphenoxy) hexyloxy group (on the phenyl ring, from a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; 1 to 5, preferably 1 to 3 groups selected from the group consisting of:

  Carbamoyl C1-6 alkoxy group [on the amino group, a C3-8 cycloalkyl group and a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group) For example, at least one group selected from the group consisting of a group selected from the group consisting of C1-6 alkoxy groups may be substituted. Carbamoylmethoxy group, 2-carbamoylethoxy group, 3-carbamoylpropoxy group, 2-carbamoylpropoxy group, 4-carbamoylbutoxy group, 5-carbamoylpentoxy group, 4-carbamoylpentoxy group, 6-carbamoylhexyloxy group, 2 -Methyl-3-carbamoylpropoxy group, 1,1-dimethyl-2-carbamoyl ester Xyl group, [N- (4-methylphenyl) carbamoyl] methoxy group, [N- (4-chlorophenyl) carbamoyl] methoxy group, [N- (4-trifluoromethylphenyl) carbamoyl] methoxy group, [N- ( 4-methoxyphenyl) carbamoyl] methoxy group, [N- (4-trifluoromethoxyphenyl) carbamoyl] methoxy group, [N- (2,4-dichlorophenyl) carbamoyl] methoxy group, [N- (2,4,6) -Trimethylphenyl) carbamoyl] methoxy group, [N- (2,4-dimethoxyphenyl) carbamoyl] methoxy group, (N-cyclohexylcarbamoyl) methoxy group, (N-cyclopentylcarbamoyl) methoxy group, (N-cycloheptylcarbamoyl) Methoxy group, (N-cyclooctylcarbamoyl Methoxy group, (N-cyclobutylcarbamoyl) methoxy group, (N-cyclopropylcarbamoyl) methoxy group, (N-cyclopropyl-N-cyclohexylcarbamoyl) methoxy group, (N, N-dicyclohexylcarbamoyl) methoxy group, [N Carbamoyl C1-6 alkoxy groups such as -cyclopropyl-N- (4-fluoromethylphenyl) carbamoyl] methoxy group, [N-cyclohexyl-N- (4-fluoromethylphenyl) carbamoyl] methoxy group [on the amino group] A C3-8 cycloalkyl group and a phenyl group (on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) 1 to 5 groups, preferably 1 to 3 groups are substituted 1 to 2 groups selected from the group consisting of (optionally) may be substituted].

  Examples of the benzofuryl C1-6 alkoxy group (at least one cyano group may be substituted on the benzofuran ring) include, for example, (2-benzofuryl) methoxy group, 2- (3-benzofuryl) ethoxy group, 3- (4-benzofuryl) propoxy group, 2- (5-benzofuryl) propoxy group, 4- (6-benzofuryl) butoxy group, 5- (7-benzofuryl) pentoxy group, 4- (2-benzofuryl) pentoxy group, 6- (3-benzofuryl) hexyloxy group, 2- (2-benzofuryl) methoxy group, 1,1-dimethyl-2- (2-benzofuryl) ethoxy group, 2-methyl-3- (3-benzofuryl) propoxy group , (7-cyano-2-benzofuryl) methoxy group, (6-cyano-2-benzofuryl) methoxy group, (5-cyano-2-phenyl) Zofuryl) methoxy, (4-cyano-2-benzofuryl) methoxy, (3-cyano-2-benzofuryl) methoxy, (2-cyano-5-benzofuryl) methoxy, (6,7-dicyano-2- Benzofuryl C1-6 alkyl groups such as (benzofuryl) methoxy group and (3,4,5-tricyano-2-benzofuryl) methoxy group (1 to 3 cyano groups may be substituted on the benzofuran ring) Can be mentioned.

  Examples of the naphthyloxy C1-6 alkyl group (at least one C1-6 alkoxy group may be substituted on the naphthalene ring) include, for example, (1- or 2-) naphthyloxymethyl group, 2- [(1- or 2-) naphthyloxy] ethyl group, 1-[(1- or 2-) naphthyloxy] ethyl group, 3-[(1- or 2-) naphthyloxy] propyl group, 2-[( 1- or 2-) naphthyloxy] butyl group, 5-[(1- or 2-) naphthyloxy] pentyl group, 4-[(1- or 2-) naphthyloxy] pentyl group, 6-[(1- Or 2-) naphthyloxy] hexyl group, 2-methyl-3-[(1- or 2-) naphthyloxy] propyl group, 1,1-dimethyl-2-[(1- or 2-) naphthyloxy] ethyl The group 2- (4-methoxy-1- Butyloxy) ethyl group, (4-methoxy-1-naphthyloxy) methyl group, 2- (3-ethoxy-1-naphthyloxy) ethyl group, 2-n-propoxy-1-naphthyloxymethyl group, 5-tert- Butoxy-2-naphthyloxymethyl group, 6-n-pentyloxy-3-naphthyloxymethyl group, 7-n-hexyloxy-4-naphthyloxymethyl group, 2- (2,4-dimethoxy-1-naphththioloxy) A naphthyloxy C1-6 alkyl group such as an ethyl group, 2- (1,2,3,4-tetramethoxy-5-naphthyloxy) ethyl group (on the naphthalene ring, 1 to 4 C1-6 alkoxy groups are present); Which may be substituted).

  Examples of the benzothiazolyloxy C1-6 alkyl group (at least one C1-6 alkyl group may be substituted on the benzothiazole ring) include (2-, 4-, 5-, 6- or 7-) benzothiazolyloxymethyl group, 2-[(2-, 4-, 5-, 6- or 7-) benzothiazolyloxy] ethyl group, 1-[(2-, 4 -, 5-, 6- or 7-) benzothiazolyloxy] ethyl group, 3-[(2-, 4-, 5-, 6- or 7-) benzothiazolyloxy] propyl group, 2- [(2-, 4-, 5-, 6- or 7-) benzothiazolyloxy] propyl group, 4-[(2-, 4-, 5-, 6- or 7-) benzothiazolyloxy ] Butyl group, 5-[(2-, 4-, 5-, 6- or 7-) benzothiazolyloxy] pentyl group, 4-[( -, 4-, 5-, 6- or 7-) benzothiazolyloxy] pentyl group, 6-[(2-, 4-, 5-, 6- or 7-) benzothiazolyloxy] hexyl group 2-methyl-3-[(2-, 4-, 5-, 6- or 7-) benzothiazolyloxy] propyl group, 1,1-dimethyl-2-[(2-, 4--5 -, 6- or 7-) benzothiazolyloxy] ethyl group, 2- (2-methyl-5-benzothiazolyloxy) ethyl group, (2-methyl-5-benzothiazolyloxy) methyl group 2- (4-ethyl-6-benzothiazolyloxy) ethyl group, (2-n-propyl-4-benzothiazolyloxy) methyl, etc., (5-tert-butyl-6-benzothiazolyl) (Oxy) methyl group, (6-n-pentyl-7-benzothiazolyloxy) methyl group, 7-n-hexyl-5-benzothiazolyloxy) methyl group, 2- (2,4-dimethyl-5-benzothiazolyloxy) ethyl group, 2- (2,4,5-trimethyl-7- A benzothiazolyloxy C1-6 alkyl group such as benzothiazolyloxy) ethyl group (1 to 3 C1-6 alkyl groups may be substituted on the benzothiazole ring); it can.

  Examples of the quinolyloxy C1-6 alkyl group (at least one C1-6 alkyl group may be substituted on the quinoline ring) include (2-, 3-, 4-, 5-, 6- , 7- or 8-) quinolyloxymethyl group, 2-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy] ethyl group, 1-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy] ethyl group, 3-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy] Propyl group, 2-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy] propyl group, 4-[(2-, 3-, 4-, 5-, 6 -, 7- or 8-) quinolyloxy] butyl group, 5-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy] pentyl. , 4-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy] pentyl group, 6-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy] hexyl group, 2-methyl-3-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy] propyl group, 1,1-dimethyl -2-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) quinolyloxy] ethyl group, 2-methyl-8-quinolyloxymethyl group, (3-ethyl-7- (Quinolyloxy) methyl group, (4-n-propyl-6-quinolyloxy) methyl group, (5-n-butyl-4-quinolyloxy) methyl group, (6-n-hexyl-5-quinolyloxy) methyl group, (2- Methyl-7-quinolyloxy) methyl group, (7-n-pentyl-6-quinolyloxy) Quinolyloxy C1 such as methyl group, (8-methyl-2-quinolyloxymethyl) group, (2,4-dimethyl-8-quinolyloxy) methyl group, (5,6,7-trimethyl-2-quinolyloxy) methyl group To 6 alkyl groups (1 to 3 C1-6 alkyl groups may be substituted on the quinoline ring).

  2,3-dihydrobenzofuryloxy C1-6 alkyl group (on the 2,3-dihydrobenzofuran ring, at least one group selected from the group consisting of a C1-6 alkyl group and an oxo group is substituted) May be, for example, (2-, 3-, 4-, 5-, 6- or 7-) 2,3-dihydrobenzofuryloxymethyl group, 2-[(2-, 3-, 4- , 5-, 6- or 7-) 2,3-dihydrobenzofuryloxy] ethyl group, 1-[(2-, 3-, 4-, 5-, 6- or 7-) 2,3-dihydrobenzo Furyloxy] ethyl group, 3-[(2-, 3-, 4-, 5-, 6- or 7-) 2,3-dihydrobenzofuryloxy] propyl group, 2-[(2-, 3-, 4-, 5-, 6- or 7-) 2,3-dihydrobenzofuryloxy] propyl group, 4-[( -, 3-, 4-, 5-, 6- or 7-) 2,3-dihydrobenzofuryloxy] butyl group, 5-[(2-, 3-, 4-, 5-, 6- or 7- ) 2,3-dihydrobenzofuryloxy] pentyl group, 4-[(2-, 3-, 4-, 5-, 6- or 7-) 2,3-dihydrobenzofuryloxy] pentyl group, 6- [ (2-, 3-, 4-, 5-, 6- or 7-) 2,3-dihydrobenzofuryloxy] hexyl group, 2-methyl-3-[(2-, 3-, 4-, 5- , 6- or 7-) 2,3-dihydrobenzofuryloxy] propyl group, 1,1-dimethyl-2-[(2-, 3-, 4-, 5-, 6- or 7-) 2,3 -Dihydrobenzofuryloxy] ethyl group, 2- (2,2-dimethyl-7-2,3-dihydrobenzofuryloxy) ethyl group, (2,2- Methyl-7-2,3-dihydrobenzofuryloxy) methyl group, 2- (3-ethyl-6-2,3-dihydrobenzofuryloxy) ethyl group, (4-n-propyl-5-2,3- Dihydrobenzofuryloxy) methyl group, (5-tert-butyl-6-2,3-dihydrobenzofuryloxy) methyl group, (6-n-pentyl-7-2,3-dihydrobenzofuryloxy) methyl group, (7-n-hexyl-5-2,3-dihydrobenzofuryloxy) methyl group, 2- (2,4-dimethyl-5-2,3-dihydrobenzofuryloxy) ethyl group, 2- (2,2 , 3-trimethyl-7-2,3-dihydrobenzofuryloxy) ethyl group, (2-oxo-5-2,3-dihydrobenzofuryloxy) methyl group, (3-oxo-6-2,3-dihydroben 2,3-dihydrobenzofuryloxy C1-6 alkyl group (2,3-dihydrobenzofuran ring) such as zofuryloxy) methyl group and (2-oxo-3-methyl-5-2,3-dihydrobenzofuryloxy) methyl group In the above, 1 to 3 groups selected from the group consisting of a C1-6 alkyl group and an oxo group may be substituted.

1,2,3,4-tetrahydronaphthyloxy C1-6 alkyl group (on the 1,2,3,4-tetrahydronaphthalene ring, at least one oxo group may be substituted)
As, for example, (1-, 2-, 5- or 6-) 1,2,3,4-tetrahydronaphthyloxymethyl group, 2-[(1-, 2-, 5- or 6-) 1, 2,3,4-tetrahydronaphthyloxy] ethyl group, 1-[(1-, 2-, 5- or 6-) 1,2,3,4-tetrahydronaphthyloxy] ethyl group, 3-[(1- , 2-, 5- or 6-) 1,2,3,4-tetrahydronaphthyloxy] propyl group, 2-[(1-, 2-, 5- or 6-) 1,2,3,4-tetrahydro Naphthyloxy] propyl group, 4-[(1-, 2-, 5- or 6-) 1,2,3,4-tetrahydronaphthyloxy] butyl group, 5-[(1-, 2-, 5- or 6-) 1,2,3,4-tetrahydronaphthyloxy] pentyl group, 4-[(1- or 2-) 1,2,3 -Tetrahydronaphthyloxy] pentyl group, 6-[(1- or 2-) 1,2,3,4-tetrahydronaphthyloxy] hexyl group, 2-methyl-3-[(1-, 2-, 5- or 6-) 1,2,3,4-tetrahydronaphthyloxy] propyl group, 1,1-dimethyl-2-[(1-, 2-, 5- or 6-) 1,2,3,4-tetrahydronaphthyl Oxy] ethyl group, [1-oxo- (2-, 5-, or 6-) 1,2,3,4-tetrahydronaphthyloxy] methyl group, [1,4-dioxo- (2-, 5- or 6-) 1,2,3,4-tetrahydronaphthyloxy] methyl group, 1,2,4-trioxo- (3-, 5-, 6-, 7- or 8-) 1,2,3,4- 1,2,3,4-tetrahydronaphthyl such as tetrahydronaphthyloxy] methyl group Oxy Cl to 6 (On 1,2,3,4-tetrahydronaphthalene ring, 1 to 3 oxo groups may be substituted) alkyl group can be exemplified.

  As the 2,3-dihydro-1H-indenyloxy C1-6 alkyl group (at least one oxo group may be substituted on the 2,3-dihydro-1H-indene ring), for example, (1-, 2-, 4- or 5-) 2,3-dihydro-1H-indenyloxymethyl group, 2-[(1-, 2-, 4- or 5-) 2,3-dihydro-1H -Indenyloxy] ethyl group, 1-[(1-, 2-, 4- or 5-) 2,3-dihydro-1H-indenyloxy] ethyl group, 3-[(1-, 2-, 4) -Or 5-) 2,3-dihydro-1H-indenyloxy] propyl group, 2-[(1-, 2-, 4- or 5-) 2,3-dihydro-1H-indenyloxy] propyl group , 4-[(1-, 2-, 4- or 5-) 2,3-dihydro-1H-indenyloxy Butyl group, 5-[(1-, 2-, 4- or 5-) 2,3-dihydro-1H-indenyloxy] pentyl group, 4-[(1-, 2-, 4- or 5-) 2,3-dihydro-1H-indenyloxy] pentyl group, 6-[(1-, 2-, 4- or 5-) 2,3-dihydro-1H-indenyloxy] hexyl group, 2-methyl- 3-[(1-, 2-, 4- or 5-) 2,3-dihydro-1H-indenyloxy] propyl group, 1,1-dimethyl-2-[(1-, 2-, 4- or 5-) 2,3-dihydro-1H-indenyloxy] ethyl group, [1-oxo- (2-, 3-, 4-, 5-, 6- or 7-) 2,3-dihydro-1H- Indenyloxy] methyl group, [1,3-dioxo- (2-, 4-, or 5-) 2,3-dihydro-1H-indenylo 2] 2,3-dihydro-1H-indenyloxy C1-6 alkyl group such as methyl group (even if 1 to 2 oxo groups are substituted on the 2,3-dihydro-1H-indene ring) Good).

  Examples of the benzooxathiolanyloxy C1-6 alkyl group (at least one oxo group may be substituted on the benzooxathiolane ring) include (2-, 4-, 5-, 6 -Or 7-) benzooxathiolanyloxymethyl group, 2-[(2-, 4-, 5-, 6- or 7-) benzooxathiolanyloxy] ethyl group, 1-[(2-, 4- , 5-, 6- or 7-) benzooxathiolanyloxy] ethyl group, 3-[(2-, 4-, 5-, 6- or 7-) benzooxathiolanyloxy] propyl group, 2- [ (2-, 4-, 5-, 6- or 7-) benzooxathiolanyloxy] propyl group, 4-[(2-, 4-, 5-, 6- or 7-) benzooxathiolanyloxy] Butyl group, 5-[(2-, 4-, 5-, 6- or 7-) benzoo Sathiolanyloxy] pentyl group, 4-[(2-, 4-, 5-, 6- or 7-) benzooxathiolanyloxy] pentyl group, 6-[(2-, 4-, 5-, 6 -Or 7-) benzooxathiolanyloxy] hexyl group, 2-methyl-3-[(2-, 4-, 5-, 6- or 7-) benzooxathiolanyloxy] propyl group, 1,1- Dimethyl-2-[(2-, 4-, 5-, 6- or 7-) benzooxathiolanyloxy] ethyl group, [2-oxo- (4-, 5-, 6- or 7-) benzoxa A benzooxathiolanyloxy C1-6 alkyl group such as a thiolanyloxy] methyl group (on the benzooxathiolane ring, one oxo group may be substituted);

  Examples of the isoquinolyloxy C1-6 alkyl group include (1-, 3-, 4-, 5-, 6-, 7- or 8-) isoquinolyloxymethyl group, 2-[(1-, 3). -, 4-, 5-, 6-, 7- or 8-) isoquinolyloxy] ethyl group, 1-[(1-, 3-, 4-, 5-, 6-, 7- or 8-) Isoquinolyloxy] ethyl group, 3-[(1-, 3-, 4-, 5-, 6-, 7- or 8-) isoquinolyloxy] propyl group, 2-[(1-, 3- , 4-, 5-, 6-, 7- or 8-) isoquinolyloxy] propyl group, 4-[(1-, 3-, 4-, 5-, 6-, 7- or 8-) iso Quinolyloxy] butyl group, 5-[(1-, 3-, 4-, 5-, 6-, 7- or 8-) isoquinolyloxy] pentyl group, 4-[(1-, 3-, 4-, 5-, 6-, 7- Is 8-) isoquinolyloxy] pentyl group, 6-[(1-, 3-, 4-, 5-, 6-, 7- or 8-) isoquinolyloxy] hexyl group, 2-methyl-3 -[(1-, 3-, 4-, 5-, 6-, 7- or 8-) isoquinolyloxy] propyl group, 1,1-dimethyl-2-[(1-, 3-, 4- , 5-, 6-, 7- or 8-) isoquinolyloxy] ethyl group.

  Examples of the pyridyloxy C1-6 alkyl group include (2-, 3- or 4-) pyridyloxymethyl group, 2-[(2-, 3- or 4-) pyridyloxy] ethyl group, and 1-[( 2-, 3- or 4-) pyridyloxy] ethyl group, 3-[(2-, 3- or 4-) pyridyloxy] propyl group, 2-[(2-, 3- or 4-) pyridyloxy] Propyl group, 4-[(2-, 3- or 4-) pyridyloxy] butyl group, 5-[(2-, 3- or 4-) pyridyloxy] pentyl group, 4-[(2-, 3- Or 4-) pyridyloxy] pentyl group, 6-[(2-, 3- or 4-) pyridyloxy] hexyl group, 2-methyl-3-[(2-, 3- or 4-) pyridyloxy] propyl The group 1,1-dimethyl-2-[(2-, 3- or 4-) pyridyloxy It can be exemplified an ethyl group.

  Examples of the dibenzofuryloxy C1-6 alkyl group include (1-, 2-, 3- or 4-) dibenzofuryloxymethyl group, 2-[(1-, 2-, 3-, 4-, 5- , 6-, 7-, or 8-) dibenzofuryloxy] ethyl group, 1-[(1-, 2-, 3- or 4-) dibenzofuryloxy] ethyl group, 3-[(1-, 2- , 3- or 4-) dibenzofuryloxy] propyl group, 2-[(1-, 2-, 3- or 4-) dibenzofuryloxy] propyl group, 4-[(1-, 2-, 3- or 4-) dibenzofuryloxy] butyl group, 5-[(1-, 2-, 3- or 4-) dibenzofuryloxy] pentyl group, 4-[(1-, 2-, 3- or 4-) dibenzo Furyloxy] pentyl group, 6-[(1-, 2-, 3- or 4-dibenzofuryloxy] he Sil group, 2-methyl-3-[(1-, 2-, 3- or 4-) dibenzofuryloxy] propyl group, 1,1-dimethyl-2-[(1-, 2-, 3- or 4 -) Dibenzofuryloxy] ethyl group and the like can be mentioned.

  Examples of the 2H-1-benzopyranyloxy C1-6 alkyl group (at least one oxo group may be substituted on the 2H-1-benzopyran ring) include, for example, (2-, 3-, 4-, 5-, 6-, 7- or 8-) 2H-1-benzopyranyloxymethyl group, 2-[(2-, 3-, 4-, 5-, 6-, 7- or 8-- ) 2H-1-benzopyranyloxy] ethyl group, 1-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) 2H-1-benzopyranyloxy] ethyl group, 3-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) 2H-1-benzopyranyloxy] propyl group, 2-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) 2H-1-benzopyranyloxy] propyl group, 4-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) 2 -1-benzopyranyloxy] butyl group, 5-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) 2H-1-benzopyranyloxy] pentyl group, 4- [(2-, 3-, 4-, 5-, 6-, 7- or 8-) 2H-1-benzopyranyloxy] pentyl group, 6-[(2-, 3-, 4-, 5- , 6-, 7- or 8-) 2H-1-benzopyranyloxy] hexyl group, 2-methyl-3-[(2-, 3-, 4-, 5-, 6-, 7- or 8- ) 2H-1-benzopyranyloxy] propyl group, 1,1-dimethyl-2-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) 2H-1-benzopyrani 2H-1-benzopyra such as [Luoxy] ethyl group, [2-oxo- (3-, 4-, 5-, 6-, 7- or 8-) 2H-1-benzopyranyloxy] methyl group. Aryloxy Cl to 6 (On 2H-1-benzopyran ring, one oxo group may be substituted) alkyl group can be exemplified.

  Examples of the benzoisoxazolyloxy C1-6 alkyl group include (3-, 4-, 5-, 6-, or 7-) benzisoxazolyloxymethyl group, 2-[(3--4 -, 5-, 6-, or 7-) benzoisoxazolyloxy] ethyl group, 1-[(3-, 4-, 5-, 6-, or 7-) benzisoxazolyloxy] ethyl Group, 3-[(3-, 4-, 5-, 6-, or 7-) benzoisoxazolyloxy] propyl group, 2-[(3-, 4-, 5-, 6-, or 7 -) Benzoisoxazolyloxy] propyl group, 4-[(3-, 4-, 5-, 6-, or 7-) benzisoxazolyloxy] butyl group, 5-[(3-, 4 -, 5-, 6-, or 7-) benzoisoxazolyloxy] pentyl group, 4-[(3-, 4-, 5-, 6-, or 7-) ben Isoxazolyloxy] pentyl group, 6-[(3-, 4-, 5-, 6-, or 7-) benzisoxazolyloxy] hexyl group, 2-methyl-3-[(3-, 4-, 5-, 6-, or 7-) benzoisoxazolyloxy] propyl group, 1,1-dimethyl-2-[(3-, 4-, 5-, 6-, or 7-) benzo And isoxazolyloxy] ethyl group.

  Examples of the benzofurazanyloxy C1-6 alkyl group include (4- or 5-) benzofurazanyloxymethyl group, 2-[(4- or 5-) benzofurazanyloxy] ethyl group, 1 -[(4- or 5-) benzofurazanyloxy] ethyl group, 3-[(4- or 5-) benzofurazanyloxy] propyl group, 2-[(4- or 5-) benzofuraza Nyloxy] propyl group, 4-[(4- or 5-) benzofurazanyloxy] butyl group, 5-[(4- or 5-) benzofurazanyloxy] pentyl group, 4-[(4- Or 5-) benzofurazanyloxy] pentyl group, 6-[(4- or 5-) benzofurazanyloxy] hexyl group, 2-methyl-3-[(4- or 5-) benzofurazanyl Oxy] propyl group, 1,1-dimethyl-2-[(4-also 5) benzofuranyl The oxy] ethyl group and the like.

  Examples of the quinoxalyloxy C1-6 alkyl group include (2-, 5- or 6-) quinoxalyloxymethyl group, 2-[(2-, 5- or 6-quinoxalyloxy) ethyl. Group, 1-[(2-, 5- or 6-quinoxalyloxy) ethyl group, 3-[(2-, 5- or 6-quinoxalyloxy] propyl group, 2-[(2- , 5- or 6-quinoxalyloxy] propyl group, 4-[(2-, 5- or 6-quinoxalyloxy] butyl group, 5-[(2-, 5- or 6-) quino Xalyloxy] pentyl group, 4-[(2-, 5- or 6-) quinoxalyloxy] pentyl group, 6-[(2-, 5- or 6-quinoxalyloxy] hexyl group, 2 -Methyl-3-[(2-, 5- or 6-quinoxalyloxy) propyl group, 1,1-dimethyl 2 - [(2-, 5- or 6-) quinoxalyl oxy] can be exemplified an ethyl group.

  Examples of the C1-6 alkoxy C1-6 alkoxy substituted C1-6 alkyl group include methoxymethoxymethyl, 2- (methoxymethoxy) ethyl, 1- (2-methoxyethoxy) ethyl, 1- (methoxymethoxy) ethyl, 2 -(3-propoxy) propoxyethyl, 3- (2-ethoxyisopropoxy) propyl, 4- (4-butoxybutoxy) butyl, 5- (5-pentyloxypentyloxy) pentyl, 6- (6-hexyloxyhexyl) An alkoxy moiety such as oxy) hexyl, 1,1-dimethyl-2- (ethoxymethoxy) ethyl, 2-methyl-3- (methoxyethoxy) propyl, 3- (propoxymethoxy) propyl group is a straight chain having 1 to 6 carbon atoms. A straight-chain or branched chain alkyl group having 1 to 6 carbon atoms, which is a chain or branched chain alkoxy group An alkoxyalkoxyalkyl group which is an alkyl group can be exemplified.

  Examples of the thienyl C1-6 alkoxy-substituted C1-6 alkyl group (at least one halogen atom may be substituted on the thiophene ring) include, for example, 2-thienylmethoxymethyl group, 3-thienylmethoxymethyl group 2- [2- (2-thienyl) ethoxy] ethyl group, 3- [3- (2-thienyl) propoxy] propyl group, 3- [3- (3-thienyl) propoxy] propyl group, 4- [4 -(2-thienyl) butoxy] butyl group, 4- [4- (3-thienyl) butoxy] butyl group, 5- [5- (2-thienyl) pentyloxy] pentyl group, 5- [5- (3- Thienyl) pentyloxy] pentyl group, 6- [6- (2-thienyl) hexyloxy] hexyl group, 6- [6- (3-thienyl) hexyloxy] hexyl group, (5-chloro- -Thienylmethoxy) methyl group, (5-chloro-3-thienylmethoxy) methyl group, 2- [2- (4-bromo-2-thienyl) ethoxy] ethyl group, 3- [3- (3-fluoro-2 -Thienyl) propoxy] propyl group, 4- [4- (5-iodo-2-thienyl) butoxy] butyl group, 4- [4- (4-chloro-3-thienyl) butoxy] butyl group, 5- [5 -(3-chloro-2-thienyl) pentyloxy] pentyl group, 5-[(2-chloro-3-thienyl) methoxy] pentyl group, 6- [2- (3-chloro-2-thienyl) ethoxy] hexyl Group, 6- [6- (5-chloro-3-thienyl) hexyloxy] hexyl group, [2- (4,5-dichloro-2-thienyl) ethoxy] methyl group, [(2,4,5-trichloro -3-thienyl) Toxyl] A thienylalkoxyalkyl in which an alkoxy moiety such as a methyl group is a linear or branched alkoxy group having 1 to 6 carbon atoms and an alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms Group (on the thiophene ring, 1 to 3 halogen atoms may be substituted as a substituent).

  Phenyl C2-6 alkenyloxy-substituted C1-6 alkyl group (on the phenyl ring, selected from the group consisting of halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups) And at least one of the groups may be substituted) is an unsubstituted, halogen-substituted or unsubstituted linear or branched alkyl group having 1 to 6 carbon atoms and a halogen-substituted or unsubstituted group. A phenyl group substituted with 1 to 5, preferably 1 to 3 groups selected from a linear or branched alkoxy group having 1 to 6 carbon atoms and at least a double bond with 2 to 6 carbon atoms. 1 to 3 alkenyl groups, and the phenyl C2-6 alkenyloxy group includes both trans and cis isomers. Examples of such phenyl C2-6 alkenyloxy C1-6 alkyl groups include (2-phenylvinyloxy) methyl group, (3-phenyl-2-propenyloxy) methyl group, 2- (4-phenyl-2). -Butenyloxy) ethyl group, 1- (4-phenyl-3-butenoxy) ethyl group, 3- (4-phenyl-1,3-butadienyloxy) propyl group, 4- (5-phenyl-1,3, 5-hexatrienyloxy) butyl group, 5- [3- (2-fluorophenyl) -2-propenyloxy] pentyl group, 6- [3- (3-fluorophenyl) -2-propenyloxy] hexyl group, [3- (4-fluorophenyl) -2-propenyloxy] methyl group, 2- [3- (2,3-difluorophenyl) -2-propenyloxy] ethyl group, -[3- (2,3,4,5,6-pentafluorophenyl) -2-propenyloxy] propyl group, 4- [3- (2,4-difluorophenyl) -2-propenyloxy] butyl group, 5- [3- (3,4-difluorophenyl) -2-propenyloxy] pentyl group, 6- [3- (3,5-difluorophenyl) -2-propenyloxy] hexyl group, [3- (2- Chlorophenyl) -2-propenyloxy] methyl group, 2- [3- (3-chlorophenyl) -2-propenyloxy] ethyl group, 3- [3- (4-chlorophenyl) -2-propenyloxy] propyl group, 4 -[3- (2,3-dichlorophenyl) -2-propenyloxy] butyl group, 5- [3- (2,4-dichlorophenyl) -2-propenyloxy] pentyl group, 6- [ -(3,4-dichlorophenyl) -2-propenyloxy] hexyl group, [3- (3,5-dichlorophenyl) -2-propenyloxy] methyl group, 2- [3- (2-bromophenyl) -2- Propenyloxy] ethyl group, 3- [3- (3-bromophenyl) -2-propenyloxy] propyl group, 4- [3- (4-bromophenyl) -2-propenyloxy] butyl group, 5- [3 -(2-methylphenyl) -2-propenyloxy] pentyl group, 6- [3- (3-methylphenyl) -2-propenyloxy] hexyl group, [3- (4-methylphenyl) -2-propenyloxy ] Methyl group, 2- [3- (2-trifluoromethylphenyl) -2-propenyloxy] ethyl group, 3- [3- (2-fluoro-4-bromophenyl) -2-pro [Penyloxy] propyl group, 4- [3- (4-chloro-3-fluorophenyl) -2-propenyloxy] butyl group, 5- [3- (2,3,4-trichlorophenyl) -2-propenyloxy] Pentyl group, 6- [3- (2,4,6-trichlorophenyl) -2-propenyloxy] hexyl group, [3- (4-isopropylphenyl) -2-propenyloxy] methyl group, 2- [3- (4-n-butylphenyl) -2-propenyloxy] ethyl group, 1- [3- (2,4-dimethylphenyl) -2-propenyloxy] ethyl group, 3- [3- (2,3-dimethyl) Phenyl) -2-propenyloxy] propyl group, [(2,6-dimethylphenyl) -2-propenyloxy] methyl group, 5- [3- (3,5-dimethylphenyl) -2-propenyl Oxy] pentyl group, 6- [3- (2,5-dimethylphenyl) -2-propenyloxy] hexyl group, [3- (2,4,6-trimethylphenyl) -2-propenyloxy] methyl group, [ 3- (3,5-ditrifluoromethylphenyl) -2-propenyloxy] methyl group, [3- (4-n-butoxyphenyl) -2-propenyloxy] methyl group, [3- (2,4-dimethoxy) Phenyl) -2-propenyloxy] methyl group, [3- (2,3-dimethoxyphenyl) -2-propenyloxy] methyl group, [3- (2,6-dimethoxyphenyl) -2-propenyloxy] methyl group , [3- (3,5-dimethoxyphenyl) -2-propenyloxy] methyl group, [3- (2,5-dimethoxyphenyl) -2-propenyloxy] methyl group [3- (3,5-ditrifluoromethoxyphenyl) -2-propenyloxy] methyl group, [3- (3-chloro-4-methoxyphenyl) -2-propenyloxy] methyl group, [3- (2- Chloro-4-trifluoromethoxyphenyl) -2-propenyloxy] methyl group, [3- (3-methyl-4-fluorophenyl) -2-propenyloxy] methyl group, [3- (4-bromo-3- Trifluoromethylphenyl) -2-propenyloxy] methyl group, [3- (3-trifluoromethylphenyl) -2-propenyloxy] methyl group, [3- (4-trifluoromethylphenyl) -2-propenyloxy ] Methyl group, [3- (2-trifluoromethoxyphenyl) -2-propenyloxy] methyl group, [3- (3-trifluoromethoxyphenyl) Enyl) -2-propenyloxy] methyl group, [3- (4-trifluoromethoxyphenyl) -2-propenyloxy] methyl group, [3- (2-methoxyphenyl) -2-propenyloxy] methyl group, [ 3- (3-methoxyphenyl) -2-propenyloxy] methyl group, [3- (4-methoxyphenyl) -2-propenyloxy] methyl group, [3- (3,4-dimethoxyphenyl) -2-propenyl Oxy] methyl group, [3- (3,5-dimethoxyphenyl) -2-propenyloxy] methyl group, [4- (4-chlorophenyl) -2-butenyloxy] methyl group, [4- (4-chlorophenyl)- 3-butenyloxy] methyl group, [5- (4-chlorophenyl) -2-pentenyloxy] methyl group, [5- (4-chlorophenyl) -4- Nthenyloxy] methyl group, [5- (4-chlorophenyl) -3-pentenyloxy] methyl group, [6- (4-chlorophenyl) -5-hexenyloxy] methyl group, [6- (4-chlorophenyl) -4- Hexenyloxy] methyl group, [6- (4-chlorophenyl) -3-hexenyloxy] methyl group, [6- (4-chlorophenyl) -3-hexenyloxy] methyl group, and the like.

  Examples of the quinolyl C1-6 alkoxy-substituted C1-6 alkyl group include (2-, 3-, 4-, 5-, 6-, 7- or 8-) quinolylmethoxymethyl group, 2- {2- [ (2-, 3-, 4-, 5-, 6-, 7- or 8-) quinolyl] ethoxy} ethyl group, 3- {3-[(2-, 3-, 4-, 5-, 6- , 7- or 8-) quinolyl] propoxy} propyl group, 4- {4-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) quinolyl] butoxy} butyl group, 5 -{5-[(2-, 3-, 4-, 5-, 6-, 7- or 8-) quinolyl] pentyloxy} pentyl group, 6- {6-[(2-, 3-, 4- , 5-, 6-, 7- or 8-) quinolyl] hexyloxy} hexyl group or the like is a linear or branched alkoxy group having 1 to 6 carbon atoms, Alkyl moiety can be exemplified quinolyl alkoxyalkyl group is a straight-chain or branched alkyl group having 1 to 6 carbon atoms.

  Examples of the piperidylcarbonyl C1-6 alkoxy-substituted C1-6 alkyl group include (1-, 2- or 3-) piperidylcarbonylmethoxymethyl group, 2- {2-[(1-, 2- or 3-) piperidyl. Carbonyl] ethoxy} ethyl group, 3- {3-[(1-, 2- or 3-) piperidylcarbonyl] propoxy} propyl group, 4- {4-[(1-, 2- or 3-) piperidylcarbonyl] Butoxy} butyl group, 5- {5-[(1-, 2- or 3-) piperidylcarbonyl] pentyloxy} pentyl group, 6- {6-[((1-, 2- or 3-) piperidylcarbonyl) [Hexyloxy] An alkoxy moiety such as a hexyl group is a linear or branched alkoxy group having 1 to 6 carbon atoms, and an alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms. It can be exemplified piperidylcarbonyl alkoxyalkyl group.

  Phenyl C2-10 alkenyl group [on the phenyl ring, halogen atom, C1-4 alkylenedioxy group, C1-6 alkylthio group, benzoyl group, cyano group, nitro group, C2-6 alkanoyloxy group, C1 as substituent A group consisting of an amino group, a hydroxyl group, a phenyl C1-6 alkoxy group, a phenoxy group, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group that may have -6 alkyl groups As at least one kind selected from the group may be substituted], for example, a phenyl C2-6 alkenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and At least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups is substituted. 2-n-pentyl-3-phenyl-2-propenyl group, 9-phenyl-2-nonenyl group, 10-phenyl-2-decenyl group, 8-phenyl-1,3 -Octadienyl group, 9-phenyl-1,3,5-nonatrienyl group, 10-2,4,6-decatrienyl group, 3- (4-methylthiophenyl) -2-propenyl group, 3- (3-methylthiophenyl) 2-propenyl group, 3- (2-methylthiophenyl) -2-propenyl group, 3- (3,4-dimethylthiophenyl) -2-propenyl group, 3- (3,4,5-trimethylthiophenyl) 2-propenyl group, 3- (4-benzoyl) -2-propenyl group, 3- (3-benzoyl) -2-propenyl group, 3- (2-benzoyl) -2-propenyl group, 3- (3 4 Dibenzoyl) -2-propenyl group, 3- (2,4,6-tribenzoyl) -2-propenyl group, 3- (4-cyanophenyl) -2-propenyl group, 3- (3-cyanophenyl) -2 -Propenyl group, 3- (2-cyanophenyl) -2-propenyl group, 3- (3,4-dicyanophenyl) -2-propenyl group, 3- (2,4,6-tricyanophenyl) -2- Propenyl group, 3- (4-acetyloxyphenyl) -2-propenyl group, 3- (4-acetyloxy-3-methoxyphenyl) -2-propenyl group, 3- (3-acetyloxyphenyl) -2-propenyl group Group, 3- (2-acetyloxyphenyl) -2-propenyl group, 3- (3,4-diacetyloxyphenyl) -2-propenyl group, 3- (2,4,6-triacetyloxyphene) Nyl) -2-propenyl group, 3- (4-dimethylaminophenyl) -2-propenyl group, 3- (4-dimethylaminophenyl) -2-propenyl group, 3- (3-methylaminophenyl) -2- Propenyl group, 3- [2- (N-methyl-N-ethylamino) phenyl] -2-propenyl group, 3- (2,4-dimethylaminophenyl) -2-propenyl group, 3- [2,4, 6-tri (dimethylamino) phenyl] -2-propenyl group, 3- (2-hydroxyphenyl) -2-propenyl group, 3- (3-hydroxyphenyl) -2-propenyl group, 3- (4-hydroxyphenyl) ) -2-propenyl group, 3- (3,5-dimethyl-4-hydroxyphenyl) -2-propenyl group, 3- (3-methoxy-4-hydroxyphenyl) -2-propenyl group 3- (2-hydroxyphenyl) -2-propenyl group, 3- (4-benzyloxyphenyl) -2-propenyl group, 3- (4-benzyloxyphenyl) -2-propenyl group, 3- (2-benzyl) Oxyphenyl) -2-propenyl group, 3- (2,4,6-tribenzyloxyphenyl) -2-propenyl group, 3- (3,4-dibenzyloxyphenyl) -2-propenyl group, 3- ( 4-phenoxyphenyl) -2-propenyl group, 3- (3-phenoxyphenyl) -2-propenyl group, 3- (2-phenoxyphenyl) -2-propenyl group, 3- (2,4-diphenoxyphenyl) 2-propenyl group, 3- (2,4,6-triphenoxyphenyl) -2-propenyl group, 3- (3,4-methylenedioxyphenyl) -2-propenyl group A phenyl group is 1 to 3 on a C2-10 alkenyl group such as a 3- (2,3-ethylenedioxyphenyl) -2-propenyl group and a 3- (3,4-ethylenedioxyphenyl) -2-propenyl group. An alkenyl group having 2 to 10 carbon atoms and 1 to 3 double bonds may be mentioned. The phenyl C2-10 alkenyl group includes both a trans isomer and a cis isomer. On the phenyl ring, it has a halogen atom, a C1-4 alkylenedioxy group, a C1-6 alkylthio group, a benzoyl group, a cyano group, a nitro group, a C2-6 alkanoyloxy group, and a C1-6 alkyl group as a substituent. A group selected from the group consisting of an amino group, a hydroxyl group, a phenyl C1-6 alkoxy group, a phenoxy group, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group 1 to 5, preferably 1 to 3 may be substituted. When the substituent is a C1-4 alkylenedioxy group, it is preferred that 1 or 2 of the group is substituted on the phenyl ring.

  Examples of the naphthyl C2-6 alkenyl group include 2- (1- or 2-) naphthyl vinyl group, 3- (1- or 2-) naphthyl-2-propenyl group, and 3- (1- or 2-) naphthyl. 2-methyl-2-propenyl group, 4- (1- or 2-) naphthyl-2-butenyl group, 4- (1- or 2-) naphthyl-3-butenyl group, 4- (1- or 2- ) Naphthyl-1,3-butadienyl group, 5- (1- or 2-) naphthyl-1,3-pentadienyl group, 6- (1- or 2-) naphthyl-1,3-hexadienyl group, 6- (1 -Or 2-) naphthyl-2-hexenyl group, 5- (1- or 2-) naphthyl-2-pentenyl group, 6- (1- or 2-) naphthyl-1,3,5-hexadienyl group, etc. 2 to 6 carbon atoms substituted by 1 to 3 double bonds And an alkenyl group. The naphthyl C2-6 alkenyl group includes both trans and cis isomers.

  Examples of the benzothienyl C2-6 alkenyl group include 2- (2-, 3-, 4-, 5-, 6- or 7-) benzothienyl vinyl group, 3- (2-, 3-, 4-, 5-, 6- or 7-) benzothienyl-2-propenyl group, 3- (2-, 3-, 4-, 5-, 6- or 7-) benzothienyl-2-methyl-2-propenyl group, 4- (2-, 3-, 4-, 5-, 6- or 7-) benzothienyl-2-butenyl group, 4- (2-, 3-, 4-, 5-, 6- or 7-) Benzothienyl-3-butenyl group, 4- (2-, 3-, 4-, 5-, 6- or 7-) benzothienyl-1,3-butadienyl group, 5- (2-, 3-, 4- , 5-, 6-, or 7-) benzothienyl-1,3-pentadienyl group, 6- (2-, 3-, 4-, 5-, 6- or 7-) benzothie 1,3-hexadienyl group, 6- (2-, 3-, 4-, 5-, 6- or 7-) benzothienyl-2-hexenyl group, 5- (2-, 3-, 4-, 5-, 6- or 7-) benzothienyl-2-pentenyl group, 6- (2-, 3-, 4-, 5-, 6- or 7-) benzothienyl-1,3,5-hexatrienyl An alkenyl group having 2 to 6 carbon atoms and 1 to 3 double bonds substituted by a benzothienyl group such as a group can be given. The benzothienyl C2-6 alkenyl group includes both trans and cis isomers.

  Examples of the benzothiazolyl C2-6 alkenyl group [at least one C1-6 alkyl group may be substituted on the benzothiazole ring] include 2- (2-, 4-, 5-, 6- Or 7-) benzothiazolyl vinyl group, 3- (2-, 4-, 5-, 6- or 7-) benzothiazolyl-2-propenyl group, 3- (2-, 4-, 5-, 6- Or 7-) benzothiazolyl-2-methyl-2-propenyl group, 4- (2-, 4-, 5-, 6- or 7-) benzothiazolyl-2-butenyl group, 4- (2-, 4-, 5) -, 6- or 7-) benzothiazolyl-3-butenyl group, 4- (2-, 4-, 5-, 6- or 7-) benzothiazolyl-1,3-butadienyl group, 5- (2-, 4- , 5-, 6- or 7-) benzothiazolyl-1,3-pentadienyl group 6- (2-, 4-, 5-, 6- or 7-) benzothiazolyl-1,3-hexadienyl group, 6- (2-, 4-, 5-, 6- or 7-) benzothiazolyl-2-hexenyl Group, 5- (2-, 4-, 5-, 6- or 7-) benzothiazolyl-2-pentenyl group, 6- (2-, 4-, 5-, 6- or 7-) benzothiazolyl-1,3 , 5-hexadienyl group, 3- (2-methyl-5-benzothiazolyl) -2-propenyl group, 3- (2-ethyl-4-benzothiazolyl) -2-propenyl group, 3- (2-n-propyl-6) -Benzothiazolyl) -2-propenyl group, 3- (2-n-butyl-7-benzothiazolyl) -2-propenyl group, 3- (4-n-pentyl-5-benzothiazolyl) -2-propenyl group, 3- ( 5-n-hexyl-2-be Benzothiazolyl such as zothiazolyl) -2-propenyl group, 3- (2,4-dimethyl-5-benzothiazolyl) -2-propenyl group, 3- (2,4,5-trimethyl-7-benzothiazolyl) -2-propenyl group An alkenyl group having 2 to 6 carbon atoms and 1 to 3 double bonds substituted with the group can be exemplified. The benzothiazolyl C2-6 alkenyl group includes both trans and cis isomers.

  A phenyl C1-6 alkyl group [on the phenyl ring, a piperidyl group (on the piperidine ring at least one phenoxy group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and At least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted] and a phenoxy group (on the phenyl ring, halogen At least one selected from the group consisting of an atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted). As examples of the substituent, it is assumed that at least one kind of the group is substituted]. For example, 4- (1-piperidyl) benzyl group, 2,4-di (4-piperi L) benzyl group, 2,4,6-tri (2-piperidyl) benzyl group, 4- [4- (4-trifluoromethoxyphenoxy) -1-piperidyl] benzyl group, 4- [4- (4-tri Fluoromethylphenoxy) -1-piperidyl] benzyl group, 4- [4- (4-chlorophenoxy) -1-piperidyl] benzyl group, 4- {4- [3,4-di (trifluoromethoxy) phenoxy]- 1-piperidyl} benzyl group, 4- {4- [2,4,6-tri (trifluoromethyl) phenoxy] -1-piperidyl} benzyl group, 4- [4- (2,4-dichlorophenoxy) -1 -Piperidyl] benzyl group, 4- [4- (2,4,6-trifluorophenoxy) -1-piperidyl] benzyl group, 3- [2,4-diphenoxy-3-piperidyl] benzyl group, -[1,2,3-triphenoxy-4-piperidyl] benzyl group, 4- (4-trifluoromethoxyphenoxy) benzyl group, 4- (4-trifluoromethylphenoxy) benzyl group, 4- (4-chloro Phenoxy) benzyl group, 4- (2,4-dichlorophenoxy) benzyl group, 4- (3,4,5-trifluorophenoxy) benzyl group, 4- (3-methylphenoxy) benzyl group, 4- (2- Methoxyphenoxy) benzyl group, 4- (2,4-dimethylphenoxy) benzyl group, 4- (3,4-dimethoxyphenoxy) benzyl group, 4- (2,4,6-trimethylphenoxy) benzyl group, 4- ( 3,4,5-trimethoxyphenoxy) benzyl group, 2,4-diphenoxybenzyl group, 2,4,6-triphenoxybenzyl group, 2-phen Phenyl C1-6 alkyl group such as oxy-4- (1-piperidyl) benzyl group [on the phenyl ring, piperidyl group (on the piperidine ring, phenoxy group [on the phenyl ring, halogen atom, halogen substitution or 1 to 5 groups, preferably 1 to 3 groups selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. 3 may be substituted) and a phenoxy group (on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) The group selected from the group consisting of 1 to 5 groups, preferably 1 to 3 groups, which may be substituted, is substituted with 1 to 3 groups].

  Diphenyl C1-6 alkyl group [on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; As the seed may be substituted, for example, a diphenylmethyl group, a 2,2-diphenylethyl group, a 1,1-diphenylethyl group, a 3,3-diphenylpropyl group, a 2,3-diphenylpropyl group, 4,4-diphenylbutyl group, 5,5-diphenylpentyl group, 4,5-diphenylpentyl group, 6,6-diphenylhexyl group, 2-methyl-3,3-diphenylpropyl group, 1,1-dimethyl- 2,2-diphenylethyl group, di (4-chlorophenyl) methyl group, di (4-trifluoromethoxyphenyl) methyl group, di 4-trifluoromethylphenyl) methyl group, di (3-methoxyphenyl) methyl group, di (2,4-dichlorophenyl) methyl group, di (2-methylphenyl) methyl group, di (2,4,6-tri Fluorophenyl) methyl group, di (3,4-dimethoxyphenyl) methyl group, di (2,4,6-trimethoxyphenyl) methyl group, di (3,4-dimethylphenyl) methyl group, di (2,4 , 6-trimethylphenyl) methyl group, 1- (4-trifluoromethoxyphenyl) -1- (4-chlorophenyl) methyl group and the like [on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1 1 to 5, preferably 1 to 3 groups selected from the group consisting of -6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups Good] can be mentioned two substituted C1~6 alkyl group.

  A benzoyl C1-6 alkyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; Species may be substituted) means an unsubstituted benzoyl C1-6 alkyl group and a halogen atom, a halogen-substituted or unsubstituted linear or branched C1 on the phenyl ring constituting the group. A group substituted with 1 to 5, preferably 1 to 3 groups selected from the group consisting of -6 alkyl groups and halogen-substituted or unsubstituted linear or branched C1-6 alkoxy groups For example, benzoylmethyl group, 1-benzoylethyl group, 2-benzoylethyl group, 3-benzoylpropyl group, 2-benzoylpropyl group, 4-benzoylpropyl group, Zoylbutyl, 5-benzoylpentyl, 4-benzoylpentyl, 6-benzoylhexyl, 2-fluorobenzoylmethyl, 3-fluorobenzoylmethyl, 4-fluorobenzoylmethyl, 2-chlorobenzoylmethyl, 3 -Chlorobenzoylmethyl group, 4-chlorobenzoylmethyl group, 2-bromobenzoylmethyl group, 3-bromobenzoylmethyl group, 4-bromobenzoylmethyl group, 2-iodobenzoylmethyl group, 3-iodobenzoylmethyl group, 4- Iodobenzoylmethyl group, 2,3-difluorobenzoylmethyl group, 3,4-difluorobenzoylmethyl group, 3,5-difluorobenzoylmethyl group, 2,4-difluorobenzoylmethyl group, 2,6-difluorobenzoylmethyl group, 2,3-dichroic Benzoylmethyl group, 3,4-dichlorobenzoylmethyl group, 3,5-dichlorobenzoylmethyl group, 2,4-dichlorobenzoylmethyl group, 2,6-dichlorobenzoylmethyl group, 2-fluoro-4-bromobenzoylmethyl group 4-chloro-3-fluorobenzoylmethyl group, 2,3,4-trichlorobenzoylmethyl group, 3,4,5-trifluorobenzoylmethyl group, 2,4,6-trichlorobenzoylmethyl group, 4-isopropylbenzoyl Methyl group, 4-n-butylbenzoylmethyl group, 4-methylbenzoylmethyl group, 2-methylbenzoylmethyl group, 3-methylbenzoylmethyl group, 2,4-dimethylbenzoylmethyl group, 2,3-dimethylbenzoylmethyl group 2,6-dimethylbenzoylmethyl group, 3,5-dimethylbenzene Nzoylmethyl group, 2,5-dimethylbenzoylmethyl group, 2,4,6-trimethylbenzoylmethyl group, 3,5-ditrifluoromethylbenzoylmethyl group, 2,3,4,5,6-pentafluorobenzoylmethyl group, 4-isopropoxybenzoylmethyl group, 4-n-butoxybenzoylmethyl group, 4-methoxybenzoylmethyl group, 2-methoxybenzoylmethyl group, 3-methoxybenzoylmethyl group, 2,4-dimethoxybenzoylmethyl group, 2,3 -Dimethoxybenzoylmethyl group, 2,6-dimethoxybenzoylmethyl group, 3,5-dimethoxybenzoylmethyl group, 2,5-dimethoxybenzoylmethyl group, 2,4,6-trimethoxybenzoylmethyl group, 3,5-ditri Fluoromethoxybenzoylmethyl group, 2-isopropo Cibenzoylmethyl group, 3-chloro-4-methoxybenzoylmethyl group, 2-chloro-4-trifluoromethoxybenzoylmethyl group, 3-methyl-4-fluorobenzoylmethyl group, 4-bromo-3-trifluoromethylbenzoyl Methyl group, 2-trifluoromethylbenzoylmethyl group, 3-trifluoromethylbenzoylmethyl group, 4-trifluoromethylbenzoylmethyl group, 2-pentafluoroethylbenzoylmethyl group, 3-pentafluoroethylbenzoylmethyl group, 4- Pentafluoroethylbenzoylmethyl group, 2-trifluoromethoxybenzoylmethyl group, 3-trifluoromethoxybenzoylmethyl group, 4-trifluoromethoxybenzoylmethyl group, 2-pentafluoroethoxybenzoylmethyl group, 3-pen Fluoroethoxybenzoylmethyl group, 4-pentafluoroethoxybenzoylmethyl group, 2- (2-trifluoromethylbenzoyl) ethyl group, 2- (3-trifluoromethylbenzoyl) ethyl group, 2- (4-trifluoromethylbenzoyl) ) Ethyl group, 2- (2-trifluoromethoxybenzoyl) ethyl group, 2- (3-trifluoromethoxybenzoyl) ethyl group, 2- (4-trifluoromethoxybenzoyl) ethyl group, 2- (2-pentafluoro) Ethoxybenzoyl) ethyl group, 2- (3-pentafluoroethoxybenzoyl) ethyl group, 2- (4-pentafluoroethoxybenzoyl) ethyl group, 3- (2-trifluoromethylbenzoyl) propyl group, 3- (3- Trifluoromethylbenzoyl) propyl group, 3- (4-to Trifluoromethylbenzoyl) propyl group, 3- (2-trifluoromethoxybenzoyl) propyl group, 3- (3-trifluoromethoxybenzoyl) propyl group, 3- (4-trifluoromethoxybenzoyl) propyl group, 3- ( 3-pentafluoroethoxybenzoyl) propyl group, 3- (4-pentafluoroethoxybenzoyl) propyl group, 4- (3-pentafluoroethoxybenzoyl) butyl group, 5- (4-trifluoromethylbenzoyl) pentyl group, 4 -(4-trifluoromethylbenzoyl) pentyl group, 4- (4-trifluoromethoxybenzoyl) pentyl group, 6- (3-trifluoromethylbenzoyl) hexyl group, 6- (4-trifluoromethylbenzoyl) hexyl group , 6- (4-Trifluoromethoxybenzo Le) hexyl group, and the like.

  C1-6 alkyl group, C1-6 alkoxycarbonyl group and phenyl C1-6 alkyl group [on the phenyl ring, a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and At least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted), halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or As an amino group that at least one group selected from the group consisting of a group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted] For example, an amino group, a tert-butoxycarbonylamino group, a methylamino group, a benzylamino group, (4-trifluoromethato Cibenzyl) amino group, (4-trifluoromethylbenzyl) amino group, (4-chlorobenzyl) amino group, [4- (4-trifluoromethoxyphenyl) benzyl] amino group, [4- (4-trifluoromethyl) Phenyl) benzyl] amino group, [4- (4-chlorophenyl) benzyl] amino group, N-methyl-N-benzylamino group, N-methyl-N- (4-trifluoromethoxybenzyl) amino group, N-methyl -N- (4-trifluoromethylbenzyl) amino group, N-methyl-N- (4-chlorobenzyl) amino group, N-methyl-N- [4- (4-trifluoromethoxyphenyl) benzyl] amino group N-methyl-N- [4- (4-trifluoromethylphenyl) benzyl] amino group, N-methyl-N- [4- (4-chlorophenyl) benzyl] Mino group, N-methoxycarbonyl-N-benzylamino group, N-ethoxycarbonyl-N- (4-trifluoromethoxybenzyl) amino group, N-propoxycarbonyl-N- (4-trifluoromethylbenzyl) amino group, Nn-butoxycarbonyl-N- (4-chlorobenzyl) amino group, Nn-pentyloxycarbonyl-N- [4- (4-trifluoromethoxyphenyl) benzyl] amino group, Nn-hexyloxy Carbonyl-N- [4- (4-trifluoromethylphenyl) benzyl] amino group, N-ethoxycarbonyl-N- [4- (4-chlorophenyl) benzyl] amino group, N, N-dimethylamino group, N- C1-C6 straight chain or molecular chain alkyl group such as methyl-N-ethylamino group, C1-C6 straight chain or molecular chain chain A phenylalkyl group in which the alkoxy group and the alkyl moiety are linear or molecular chain alkyl groups having 1 to 6 carbon atoms [on the phenyl ring, a phenyl group (on the phenyl ring, a halogen atom, halogen-substituted or 1 to 5 groups selected from the group consisting of a substituted C1-6 linear or molecular chain alkyl group and a halogen-substituted or unsubstituted C1-6 linear or molecular chain alkoxy group, preferably 1 ~ 3 may be substituted), halogen atom, halogen-substituted or unsubstituted C1-6 linear or molecular chain alkyl group and halogen-substituted or unsubstituted C1-6 linear or molecular chain alkoxy A group selected from the group consisting of 1 to 5 groups, preferably 1 to 3 groups may be substituted], and an amino group optionally selected from 1 to 2 groups selected from the group consisting of thing It can be.

  A C1-6 alkyl group and a phenyl group (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; Examples of the amino C1-6 alkyl group that may be substituted with at least one group selected from the group consisting of (which may be substituted at least one) include, for example, an aminomethyl group, a 2-aminoethyl group, 1-aminoethyl group, 3-aminopropyl group, 4-aminobutyl group, 5-aminopentyl group, 6-aminohexyl group, 2-methyl-3-aminopropyl group, 1,1-dimethyl-2-aminoethyl Group, ethylaminomethyl group, 1- (propylamino) ethyl group, 2- (methylamino) ethyl group, 3- (isopropylamino) propyl group, 4- ( -Butylamino) butyl group, 5- (n-pentylamino) pentyl group, 6- (n-hexylamino) hexyl group, dimethylaminomethyl group, (N-ethyl-N-propylamino) methyl group, 2- ( N-methyl-Nn-hexylamino) ethyl group, phenylaminomethyl group, 1- (phenylamino) ethyl group, 2- (4-chloroanilino) ethyl group, 2- (4-trifluoromethoxyanilino) ethyl Group, 2- (4-trifluoromethylanilino) ethyl group, 3- (4-fluoroanilino) propyl group, 4- (3,4-difluoroanilino) butyl group, 5- (3,4,6) -Trifluoroanilino) pentyl group, 6- (4-methylanilino) hexyl group, (3-methoxyanilino) methyl group, (2,3,4-trimethoxyanilino) methyl group (3,4-dimethylanilino) methyl group, (2,4,6-trimethylanilino) methyl group, [N-ethyl-N- (3,4-dimethoxyanilino)] methyl group, 2- [N -Methyl-N- (4-chloroanilino)] ethyl group, 2- [N-methyl-N- (4-trifluoromethoxyanilino)] ethyl group, 2- [N-methyl-N- (4-trifluoro) Methylanilino)] straight chain or molecular chain alkyl group having 1 to 6 carbon atoms such as ethyl group and phenyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 straight chain or molecule 1 to 5, preferably 1 to 3 groups selected from the group consisting of a chain alkyl group and a halogen-substituted or unsubstituted C1-6 linear or molecular chain alkoxy group) 1 to 2 groups selected from the group consisting of Alkyl moiety can be mentioned an aminoalkyl group is a straight-chain or chain alkyl group having 1 to 6 carbon atoms.

  A benzofuryl C2-6 alkenyl group [on the benzofuran ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; Examples of the optionally substituted species] include 2-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] vinyl group, 3-[(2-, 3- , 4-, 5-, 6- or 7-) benzofuryl] -2-propenyl group, 3-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] -2-methyl- 2-propenyl group, 4-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] -2-butenyl group, 4-[(2-, 3-, 4-, 5- , 6- or 7-) benzofuryl] -3-butenyl group, 4-[(2-, 3-, 4-, 5-, 6) Or 7-) benzofuryl] -1,3-butadienyl group, 5-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] -1,3,5-hexatrienyl group, 5-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] -2,4-hexadienyl group, 5-[(2-, 3-, 4-, 5-, 6- Or 7-) benzofuryl] -3-pentenyl group, 3- [5-trifluoromethyl- (2-, 3-, 4-, 6- or 7-) benzofuryl] -2-propenyl group, 3- [5- Trifluoromethoxy- (2-, 3-, 4-, 6- or 7-) benzofuryl] -2-propenyl group, 3- [6-trifluoromethyl- (2-, 3-, 4-, 5- or 7-) benzofuryl] -2-propenyl group, 3- [4-chloro- (2-, 3-, 5-, 6- or 7-) benzofuryl] -2-propene Nyl group, 3- [4,5-dimethoxy- (2-, 3-, 6- or 7-) benzofuryl] -2-propenyl group, 3- [3,4,5-trimethyl- (2-, 6- Or an alkenyl moiety such as 7-) benzofuryl] -2-propenyl group or 3- [3-methyl-5-methoxy- (2-, 4-, 6- or 7-) benzofuryl] -2-propenyl group A benzofurylalkenyl group having 1 to 2 double or 6 straight chain or molecular chain double bonds, including both trans and cis forms [on the benzofuran ring, a halogen atom, halogen 1 to 3 groups selected from the group consisting of a substituted or unsubstituted C1-6 linear or molecular chain alkyl group and a halogen-substituted or unsubstituted C1-6 linear or molecular chain alkoxy group are substituted You may have] That.

  A piperidyl group [on the piperidine ring at least one phenyl C2-6 alkenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 The group may be substituted with at least one selected from the group consisting of alkoxy groups]. For example, (1-, 2-, 3- or 4-) piperidyl group 1- (3-phenyl-2-propenyl)-(2-, 3- or 4-) piperidyl group, 1,3-di (3-phenyl-2-propenyl)-(2-, 4-, 5- Or 6) piperidyl group, 1,2,4-tri (3-phenyl-2-propenyl)-(3-, 5- or 6) piperidyl group, 1- [3- (4-trifluoromethoxyphenyl) -2-propenyl]-( -, 3- or 4-) piperidyl group, 1- [3- (4-trifluoromethylphenyl) -2-propenyl]-(2-, 3- or 4-) piperidyl group, 1- [3- (4 -Chlorophenyl) -2-propenyl]-(2-, 3- or 4-) piperidyl group, 1- [3- (3,4-dimethoxyphenyl) -2-propenyl]-(2-, 3- or 4- ) Piperidyl group, 1- [3- (2,4,6-trimethylphenyl) -2-propenyl]-(2-, 3- or 4-) piperidyl group and the like [on the piperidine ring, Three alkenyl moieties as described above are straight-chain or molecular chains having 2 to 6 carbon atoms and having 1 to 3 double bonds, and include phenyl alkenyl groups including both trans and cis isomers ( On the phenyl ring, a halogen atom, halogen substitution or 1 to 5 groups selected from the group consisting of a substituted C1-6 linear or molecular chain alkyl group and a halogen-substituted or unsubstituted C1-6 linear or molecular chain alkoxy group, preferably 1 -3 may be substituted) may be substituted].

  Examples of the ferrocene-substituted C1-6 alkyl group include a ferrocene methyl group, a 1-ferrocene ethyl group, a 2-ferrocene ethyl group, a 3-ferrocene propyl group, a 2-ferrocene propyl group, a 4-ferrocene butyl group, and a 5-ferrocene pentyl group. A straight chain or molecule in which the alkyl moiety such as a group, 4-ferrocenepentyl group, 6-ferrocenehexyl group, 1,1-dimethyl-2-ferroceneethyl group, 2-methyl-3-ferrocenepropyl group, etc. has 1 to 6 carbon atoms A ferrocene alkyl group which is a chain alkyl group can be exemplified.

  Examples of the indolyl C1-6 alkyl group (at least one halogen atom may be substituted on the indole ring) include, for example, [(1-, 2-, 3-, 4-, 5-, 6 -Or 7-) Indolyl] methyl group, 1-[(1-, 2-, 3-, 4-, 5-, 6- or 7-) indolyl] ethyl group, 2-[(1-, 2-, 3-, 4-, 5-, 6- or 7-) indolyl] ethyl group, 3-[(1-, 2-, 3-, 4-, 5-, 6- or 7-) indolyl] propyl group, 2-[(1-, 2-, 3-, 4-, 5-, 6- or 7-) indolyl] propyl group, 4-[(1-, 2-, 3-, 4-, 5-, 6 -Or 7-) indolyl] butyl group, 5-[(1-, 2-, 3-, 4-, 5-, 6- or 7-) indolyl] pentyl group, 4-[(1-, 2-, 3-, 4-, 5-, 6- or 7 ) Indolyl] pentyl group, 6-[(1-, 2-, 3-, 4-, 5-, 6- or 7-) indolyl] hexyl group, 1,1-dimethyl-2-[(1-, 2) -, 3-, 4-, 5-, 6- or 7-) indolyl] ethyl group, 2-methyl-3-[(1-, 2-, 3-, 4-, 5-, 6- or 7- ) Indolyl] propyl group, [5-chloro- (1-, 2-, 3-, 4-, 6- or 7-) indolyl] methyl group, [5,6-difluoro- (1-, 2-, 3) An alkyl moiety such as —, 4- or 7-) indolyl] methyl group, [3,5,6-tribromo- (1-, 2-, 4- or 7-) indolyl] methyl group has 1 to 6 carbon atoms; Examples thereof include an indolylalkyl group which is a linear or molecular chain alkyl group (1 to 3 halogen atoms may be substituted on the indole ring).

  Examples of the phenyl C2-6 alkynyl group include 2-phenylethynyl group, 3-phenyl-2-propynyl group, 3-phenyl-1-methyl-2-propynyl group, 4-phenyl-2-butynyl group, 4- Linear or molecular chain having 2 to 6 carbon atoms in the alkynyl moiety such as phenyl-3-butynyl group, 4-phenyl-1-butynyl group, 5-phenyl-2-pentynyl group, and 6-phenyl-2-hexynyl group An example is a phenylalkynyl group which is a alkynyl group.

  Phenyl group [on the phenyl ring, a C1-4 alkylenedioxy group, a phenyl group, a C1-6 alkoxycarbonyl group, a hydroxyl group and a phenoxy group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of an alkyl group and a group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted) Examples of such as 4-biphenyl group, 4-tert-butoxycarbonylphenyl group, 4-ethoxycarbonylphenyl group, 2-biphenyl group, 4-hydroxyphenyl group, 4- (4-chlorophenoxy) Phenyl group, 2,3-ethylenedioxyphenyl group, 3-biphenyl group, 3-tert-butoxycarbonylphenol Group, 3-methoxycarbonylphenyl group, 2,4-diphenylphenyl group, 3-hydroxyphenyl group, 4- (4-trifluoromethoxyphenoxy) phenyl group, 2,3-methylenedioxyphenyl group, 2,4 , 6-triphenyl group, 2-tert-butoxycarbonylphenyl group, 2-propoxycarbonylphenyl group, 2-n-pentyloxyphenyl group, 2-hydroxyphenyl group, 4- (4-trifluoromethylphenoxy) phenyl group 3,4-ethylenedioxyphenyl group, 2,4,6-trihydroxyphenyl group, 4-n-hexyloxycarbonylphenyl group, 2,4-diethoxycarbonylphenyl group, 2-biphenyl group, 3,4 -Dihydroxyphenyl group, 4- (2,4-dichlorophenoxy) phenyl group, 3- 2,4,6-trifluorophenoxy) phenyl group, 2,4,6-triethoxycarbonylphenyl group, 3- (2-methylphenoxy) phenyl group, 4- (3-methylphenoxy) phenyl group, 2- ( 4-methylphenoxy) phenyl group, 3- (2,3-dimethylphenoxy) phenyl group, 4- (2,4,5-trimethylphenoxy) phenyl group, 3- (2-methoxyphenoxy) phenyl group, 4- ( 3-methoxyphenoxy) phenyl group, 2- (4-methoxyphenoxy) phenyl group, 3- (3,4-dimethoxyphenoxy) phenyl group, 4- (2,4,6-trimethoxyphenoxy) phenyl group, 2- Phenyl groups such as phenoxy-4-ethoxycarbonylphenyl group and 2-phenyl-3-phenoxyphenyl group [on the phenyl ring, C1 -4 alkylenedioxy group, phenyl group, C1-6 alkoxycarbonyl group, hydroxyl group and phenoxy group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1 A group selected from the group consisting of 1 to 5 groups, preferably 1 to 3 groups selected from the group consisting of -6 alkoxy groups, and 1 to 3 groups substituted. Can be mentioned.

  As the benzofuryl group [on the benzofuran ring, at least one group selected from the group consisting of a halogen atom and a C1-6 alkyl group may be substituted], for example, (2-, 3-, 4- 5-, 6- or 7-) benzofuryl group, 5-chloro-7-benzofuryl group, 5-methyl-7-benzofuryl group, 4-iodo-6-benzofuryl group, 6-ethyl-7-benzofuryl group, 6 -Bromo-5-benzofuryl group, 7-n-propyl-4-benzofuryl group, 7-fluoro-2-benzofuryl group, 4-n-butyl-2-benzofuryl group, 2,5-dichloro-7-benzofuryl group, 5,6-dimethyl-7-benzofuryl group, 3,5,6-trifluoro-2-benzofuryl group, 3,4,5-trimethyl-3-benzofuryl group, 5-chloro-4-methyl-7- A benzofuryl group such as a nzofuryl group or a 5-methyl-3-fluoro-8-benzofuryl group [on the benzofuran ring, 1 to 3 groups selected from the group consisting of a halogen atom and a C1-6 alkyl group are substituted. May be included].

  Examples of the benzothiazolinyl group [at least one oxo group may be substituted on the benzothiazoline ring] include, for example, (2-, 4-, 5-, 6- or 7-) benzothiazolyl group And benzothiazolinyl groups such as 2-oxo-6-benzothiazolyl group [one oxo group may be substituted on the benzothiazoline ring].

  Examples of the benzothienyl group [at least one halogen atom may be substituted on the benzothiophene ring] include (2-, 3-, 4-, 5-, 6- or 7-) benzo Thienyl group, 5-fluoro-4-benzothienyl group, 6-fluoro-2-benzothienyl group, 2-chloro-3-benzothienyl group, 3-bromo-6-benzothienyl group, 4-iodo-5-benzo Benzothienyl group such as thienyl group, 2,4,6-trichloro-7-benzothienyl group, 4,5-difluoro-2-benzothienyl group [1-3 halogen atoms are substituted on benzothiophene ring May be included].

  1,2,3,4-tetrahydroquinolyl group (on the 1,2,3,4-tetrahydroquinoline ring, at least one group selected from the group consisting of an oxo group and a C1-6 alkyl group is substituted. (Optionally) include, for example, (1-, 2-, 3-, 4-, 5-, 6-, 7- or 8-) 1,2,3,4-tetrahydroquinolyl group, 2- Oxo- (1-, 3-, 4-, 5-, 6-, 7- or 8-) 1,2,3,4-tetrahydroquinolyl group, 2,4-dioxo- (1-, 3-, 5-, 6-, 7- or 8-) 1,2,3,4-tetrahydroquinolyl group, 3-oxo- (1-, 2-, 4-, 5-, 6-, 7- or 8- ) 1,2,3,4-tetrahydroquinolyl group, 1-methyl-2-oxo-5-1,2,3,4-tetrahydroquinolyl group, 2-methyl-1-1, , 3,4-tetrahydroquinolyl group, 3-ethyl-2-1,2,3,4-tetrahydroquinolyl group, 4-n-propyl-3-1,2,3,4-tetrahydroquinolyl group, 5-n-butyl-4-1,2,3,4-tetrahydroquinolyl group, 6-n-pentyl-5-1,2,3,4-tetrahydroquinolyl group, 7-n-hexyl-6 1,2,3,4-tetrahydroquinolyl group, 8-methyl-7-1,2,3,4-tetrahydroquinolyl group, 4,6-dimethyl-5-1,2,3,4-tetrahydroquinoyl group 1,2,3,4-tetrahydroquinolyl group (1,2,3,4-tetrahydroquinoline) such as lyl group, 5,6,7-trimethyl-4-1,2,3,4-tetrahydroquinolyl group A group selected from the group consisting of an oxo group and a C1-6 alkyl group is 1 on the ring. Three be substituted can be mentioned may also be).

  As the 1,2-dihydrohydroquinolyl group (at least one oxo group may be substituted on the 1,2-dihydrohydroquinoline ring), for example, (1-, 2-, 3-, 4-, 5-, 6-, 7- or 8-) 1,2-dihydrohydroquinolyl group, 2-oxo-1-, 3-, 4-, 5-, 6-, 7- or 8-) 1 1,2-dihydrohydroquinolyl group such as 1,2-dihydrohydroquinolyl group.

  (One oxo group may be substituted on the 1,2-dihydrohydroquinoline ring) 1,2,3,4-tetrahydroquinazolinyl group [1,2,3,4-tetrahydroquinazoline On the ring, at least one group selected from the group consisting of an oxo group and a C1-6 alkyl group may be substituted], for example, (1-, 2-, 3-, 4-, 5-, 6-, 7- or 8-) 1,2,3,4-tetrahydroquinazolinyl group, 2-oxo- (1-, 3-, 4-, 5-, 6-, 7- or 8 -) 1,2,3,4-tetrahydroquinazolinyl group, 4-oxo- (1-, 2-, 3-, 5-, 6-, 7- or 8-) 1,2,3,4- Tetrahydroquinazolinyl group, 2,4-dioxo- (1-, 3-, 5-, 6-, 7- or 8-) 1,2,3,4-tetrahydroquina Linyl group, 1-methyl-2,4-dioxo- (3-, 5-, 6-, 7- or 8-) 1,2,3,4-tetrahydroquinazolinyl group, 3-ethyl-2,4 -Dioxo- (1-, 5-, 6-, 7- or 8-) 1,2,3,4-tetrahydroquinazolinyl group, 1,3-dimethyl-2,4-dioxo (5-, 6- , 7- or 8-) 1,2,3,4-tetrahydroquinazolinyl group, 1-n-propyl-5-methyl-2-oxo- (3-, 4-, 6-, 7- or 8- ) 1,2,3,4-tetrahydroquinazolinyl group, 1-n-butyl-6-methyl-4-oxo (2-, 3-, 5-, 7- or 8-) 1,2,3 4-tetrahydroquinazolinyl group, 1-n-pentyl-7-methyl-2-oxo- (3-, 4-, 5-, 6- or 8-) 1,2,3,4-teto 1 such as hydroquinazolinyl group, 1-n-hexyl-8-methyl-2,4-dioxo- (3-, 5-, 6- or 7-) 1,2,3,4-tetrahydroquinazolinyl group , 2,3,4-tetrahydroquinazolinyl group [on the 1,2,3,4-tetrahydroquinazoline ring, 1 to 4 groups selected from the group consisting of an oxo group and a C1-6 alkyl group are substituted. May be included].

  Examples of the benzothienyl-substituted C1-6 alkyl group [at least one halogen atom may be substituted on the benzothiophene ring] include, for example, 2-benzothienylmethyl group, 3-benzothienylmethyl group, 4 -Benzothienylmethyl group, 5-benzothienylmethyl group, 6-benzothienylmethyl group, 7-benzothienylmethyl group, 2- (2-benzothienyl) ethyl group, 3- (2-benzothienyl) propyl group, 4 -(2-benzothienyl) butyl group, 5- (2-benzothienyl) pentyl group, 6- (2-benzothienyl) hexyl group, 5-chloro-3-benzothienylmethyl group, 3,4-dibromo-2 A benzothienyl-substituted C1-6 alkyl group such as benzothienylmethyl group or 4,5,6-trichloro-2-benzothienylmethyl group On Zochiofen ring include a halogen atom may also be one to three substituents.

  Examples of the naphthyl-substituted C1-6 alkyl group include 1-naphthylmethyl group, 2-naphthylmethyl group, 2- (1-naphthyl) ethyl group, 1- (2-naphthyl) ethyl group, and 3- (1-naphthyl). ) Propyl group, 3- (2-naphthyl) propyl group, 4- (1-naphthyl) butyl group, 4- (2-naphthyl) butyl group, 5- (1-naphthyl) pentyl group, 5- (2-naphthyl) ) Pentyl group, 6- (1-naphthyl) hexyl group, 6- (2-naphthyl) hexyl group and the like.

  As the naphthyl-substituted C1-6 alkyl group (at least one C1-6 alkoxy group may be substituted on the naphthalene ring), for example, [(1- or 2-) naphthyl] methyl group, 1 -[(1- or 2-) naphthyl] ethyl group, 2-[(1- or 2-) naphthyl] ethyl group, 3-[(1- or 2-) naphthyl] propyl group, 2-[(1- Or 2-) naphthyl] propyl group, 4-[(1- or 2-) naphthyl] butyl group, 5-[(1- or 2-) naphthyl] pentyl group, 4-[(1- or 2-) naphthyl ] Pentyl group, 6-[(1- or 2-) naphthyl] hexyl group, 1,1-dimethyl-2-[(1- or 2-) naphthyl] ethyl group, 2-methyl-3-[(1- Or 2-) naphthyl] propyl group, [6-methoxy- (1-, 2-, 3-, 4-, 5-, 7- or 8-) naphthyl. ] Methyl group, [5,6-dimethoxy- (1-, 2-, 3-, 4-, 7- or 8-) naphthyl] methyl group, [5,6,7-trimethoxy- (1-, 2- , 3-, 4-, or 8-) naphthyl] methyl group or the like is a naphthyl-substituted alkyl group in which the alkyl group is a linear or molecular chain alkyl group having 1 to 6 carbon atoms (on the naphthalene ring, 1 to 3 Or a linear or molecular chain alkoxy group having 1 to 6 carbon atoms may be substituted).

  Examples of the pyridyl-substituted C1-6 alkyl group [at least one halogen atom may be substituted on the pyridine ring] include, for example, 2-pyridylmethyl group, 3-pyridylmethyl group, 4-pyridylmethyl group 2- (2-pyridyl) ethyl group, 2- (3-pyridyl) ethyl group, 2- (4-pyridyl) ethyl group, 3- (2-pyridyl) propyl group, 3- (3-pyridyl) propyl group 3- (4-pyridyl) propyl group, 4- (2-pyridyl) butyl group, 4- (3-pyridyl) butyl group, 4- (4-pyridyl) butyl group, 5- (2-pyridyl) pentyl group , 5- (3-pyridyl) pentyl group, 5- (4-pyridyl) pentyl group, 6- (2-pyridyl) hexyl group, 6- (3-pyridyl) hexyl group, 6- (4-pyridyl) hexyl group 2-chloro-3 Pyridylmethyl group, 3-bromo-2-pyridylmethyl group, 4-fluoro-2-pyridylmethyl group, 2- (2-chloro-4-pyridyl) ethyl group, 2- (3-chloro-5-pyridyl) ethyl Group, 2- (4-iodo-3-pyridyl) ethyl group, 3- (2-bromo-5-pyridyl) propyl group, 3- (3-fluoro-4-pyridyl) propyl group, 3- (4-chloro) -2-pyridyl) propyl group, 4- (2-iodo-5-pyridyl) butyl group, 4- (3-bromo-5-pyridyl) butyl group, 4- (4-chloro-3-pyridyl) butyl group, 5- (2-chloro-5-pyridyl) pentyl group, 5- (3-fluoro-2-pyridyl) pentyl group, 5- (4-bromo-2-pyridyl) pentyl group, 6- (2-chloro-5) -Pyridyl) hexyl group, 6- (3-F Olo-4-pyridyl) hexyl group, 6- (4-bromo-2-pyridyl) hexyl group, (2,6-dichloro-4-pyridyl) methyl group, (2,3,4-trichloro-6-pyridyl) And a pyridyl-substituted C1-6 alkyl group such as a methyl group [on the pyridine ring, 1 to 3 halogen atoms may be substituted as a substituent].

  Examples of the furyl-substituted C1-6 alkyl group [at least one nitro group may be substituted on the furan ring] include 2-furylmethyl group, 3-furylmethyl group, 2- (2- Furyl) ethyl, 3- (2-furyl) propyl, 3- (3-furyl) propyl, 4- (2-furyl) butyl, 4- (3-furyl) butyl, 5- (2- Furyl) pentyl group, 5- (3-furyl) pentyl group, 6- (2-furyl) hexyl group, 6- (3-furyl) hexyl group, 5-nitro-2-furylmethyl group, 5-nitro-3 -Furylmethyl group, 2- (5-nitro-2-furyl) ethyl group, 3- (5-nitro-2-furyl) propyl group, 4- (5-nitro-2-furyl) butyl group, 4- ( 5-nitro-3-furyl) butyl group, 5- (5-nitro-2-fur) L) pentyl, 5- (5-nitro-3-furyl) pentyl, 6- (5-nitro-2-furyl) hexyl, 6- (5-nitro-3-furylhexyl), (4 Furyl-substituted C1-6 alkyl groups such as 5-dinitro-2-furyl) methyl group and (2,4,5-trinitro-3-furyl) methyl group [on the furan ring, nitro group is 1 to 3 may be substituted].

  Examples of the thienyl-substituted C1-6 alkyl group [at least one halogen atom may be substituted on the thiophene ring] include, for example, 2-thienylmethyl group, 3-thienylmethyl group, 2- (2- Thienyl) ethyl group, 3- (2-thienyl) propyl group, 3- (3-thienyl) propyl group, 4- (2-thienyl) butyl group, 4- (3-thienyl) butyl group, 5- (2- Thienyl) pentyl group, 5- (3-thienyl) pentyl group, 6- (2-thienyl) hexyl group, 6- (3-thienyl) hexyl group, 5-chloro-2-thienylmethyl group, 5-chloro-3 -Thienylmethyl group, 2- (4-bromo-2-thienyl) ethyl group, 3- (3-fluoro-2-thienyl) propyl group, 4- (5-iodo-2-thienyl) butyl group, 4- ( 4-chloro-3- Enyl) butyl group, 5- (3-chloro-2-thienyl) pentyl group, 5- (2-chloro-3-thienyl) pentyl group, 6- (3-chloro-2-thienyl) hexyl group, 6- ( Thienyl-substituted C1-6 alkyl groups such as (5-chloro-3-thienyl) hexyl group, (4,5-dichloro-2-thienyl) methyl group, (2,4,5-trichloro-3-thienyl) methyl group ( On the thiophene ring, 1 to 3 halogen atoms may be substituted as substituents.

  As the phenyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom and a halogen-substituted or unsubstituted C1-6 alkyl group may be substituted), for example, a phenyl group 2-fluorophenyl group, 3-fluorophenyl group, 4-fluorophenyl group, 2-chlorophenyl group, 3-chlorophenyl group, 4-chlorophenyl group, 2-bromophenyl group, 3-bromophenyl group, 4-bromophenyl Group, 2-iodophenyl group, 3-iodophenyl group, 4-iodophenyl group, 2,3-difluorophenyl group, 3,4-difluorophenyl group, 3,5-difluorophenyl group, 2,4-difluorophenyl Group, 2,6-difluorophenyl group, 2,3-dichlorophenyl group, 3,4-dichlorophenyl group, 3,5 Dichlorophenyl group, 2,4-dichlorophenyl group, 2,6-dichlorophenyl group, 3,4,5-trifluorophenyl group, 3,4,5-trichlorophenyl group, 2,4,6-trifluorophenyl group, 2 , 4,6-trichlorophenyl group, 2-fluoro-4-bromophenyl group, 4-chloro-3-fluorophenyl group, 2,3,4-trichlorophenyl group, 3,4,5-trifluorophenyl group, 2,3,4,5,6-pentafluorophenyl group, 2,4,6-trimethylphenyl group, 4-n-butylphenyl group, 2,4-dimethylphenyl group, 2,3-dimethylphenyl group, 2 , 6-dimethylphenyl group, 3,5-dimethylphenyl group, 2,5-dimethylphenyl group, 3,5-ditrifluoromethylphenyl group, 3-methyl-4-fur Rophenyl group, 4-bromo-3-trifluoromethylphenyl group, 2-methylphenyl group, 3-methylphenyl group, 4-methylphenyl group, 2-methyl-3-chlorophenyl group, 3-methyl-4-chlorophenyl group 2-chloro-4-methylphenyl group, 2-methyl-3-fluorophenyl group, 2-trifluoromethylphenyl group, 3-trifluoromethylphenyl group, 4-trifluoromethylphenyl group, 2-pentafluoroethyl Phenyl group, 3-pentafluoroethylphenyl group, 4-pentafluoroethylphenyl group, 2-isopropylphenyl group, 3-isopropylphenyl group, 4-isopropylphenyl group, 2-tert-butylphenyl group, 3-tert-butyl Phenyl group, 4-tert-butylphenyl group, 2-sec- Butylphenyl group, 3-sec-butylphenyl group, 4-sec-butylphenyl group, 2-n-heptafluoropropylphenyl group, 3-n-heptafluoropropylphenyl group, 4-n-heptafluoropropylphenyl group, 4-n-pentylphenyl group, 4-n-hexylphenyl group, 2,3,4-trifluorophenyl group, 2,4,6-trifluorophenyl group and the like can be mentioned.

  Thiazolyl-substituted C1-6 alkyl group [on the thiazole ring selected from the group consisting of a C1-6 alkyl group and a phenyl group (on the phenyl ring, a halogen atom and a halogen-substituted or unsubstituted C1-6 alkyl group The group selected from the group consisting of at least one group optionally substituted) may be substituted], for example, 4-thiazolylmethyl group, 5-thiazolylmethyl group, 2- Methyl-4-thiazolylmethyl group, 2-methyl-5-thiazolylmethyl group, 2,5-dimethyl-4-thiazolylmethyl group, 2,4-dimethyl-5-thiazolylmethyl group, 2-methyl-5-phenyl-4-thiazolylmethyl group 2-methyl-4-phenyl-5-thiazolylmethyl group, 2-phenyl-4-thiazolylmethyl group, 2-phenyl- -Thiazolylmethyl group, 2-phenyl-5-methyl-4-thiazolylmethyl group, 2-phenyl-4-methyl-5-thiazolylmethyl group, 2-methyl-5- (2-fluorophenyl) -4-thiazolylmethyl group, 2- Methyl-4- (2-fluorophenyl) -5-thiazolylmethyl group, 2- (2-chlorophenyl) -4-thiazolylmethyl group, 2- (2-bromophenyl) -5-thiazolylmethyl group, 2- (2-fluorophenyl) ) -5-methyl-4-thiazolylmethyl group, 2- (2-fluorophenyl) -4-methyl-5-thiazolylmethyl group, 2-methyl-5- (3-iodophenyl) -4-thiazolylmethyl group, 2-methyl -4- (3-fluorophenyl) -5-thiazolylmethyl group, 2- (2,3-difluorophenyl) -4-thia Rylmethyl group, 2- (3-fluorophenyl) -5-thiazolylmethyl group, 2- (3-fluorophenyl) -5-methyl-4-thiazolylmethyl group, 2- (3-fluorophenyl) -4-methyl-5 Thiazolylmethyl group, 2-methyl-5- (2,4,6-trichlorophenyl) -4-thiazolylmethyl group, 2-methyl-4- (2,3,4,5,6-pentafluorophenyl) -5-thiazolylmethyl Group, 2- (4-fluorophenyl) -4-thiazolylmethyl group, 4- (2-fluorophenyl) -5-thiazolylmethyl group, 2- (4-fluorophenyl) -5-methyl-4-thiazolylmethyl group, 2- (4-Fluorophenyl) -4-methyl-5-thiazolylmethyl group, 2-methyl-5- (2-chlorophenyl) -4-thiazolylmethyl group 2-methyl-4- (2-chlorophenyl) -5-thiazolylmethyl group, 2- (2-chlorophenyl) -4-thiazolylmethyl group, 2- (2-chlorophenyl) -5-thiazolylmethyl group, 2- (2-chlorophenyl) ) -5-methyl-4-thiazolylmethyl group, 2- (2-chlorophenyl) -4-methyl-5-thiazolylmethyl group, 2-methyl-5- (3-chlorophenyl) -4-thiazolylmethyl group, 2-methyl-4 -(3-chlorophenyl) -5-thiazolylmethyl group, 2- (3-chlorophenyl) -4-thiazolylmethyl group, 2- (2-fluorophenyl) -5-thiazolylmethyl group, 2- (3-chlorophenyl) -5-methyl -4-thiazolylmethyl group, 2- (3-chlorophenyl) -4-methyl-5-thiazolylmethyl group, 2-methyl 5- (4-chlorophenyl) -4-thiazolylmethyl group, 2-methyl-4- (4-chlorophenyl) -5-thiazolylmethyl group, 2- (4-chlorophenyl) -4-thiazolylmethyl group, 2- (4- Chlorophenyl) -5-thiazolylmethyl group, 2- (4-chlorophenyl) -5-methyl-4-thiazolylmethyl group, 2- (4-chlorophenyl) -4-methyl-5-thiazolylmethyl group, 2- (2-thiazolyl) ethyl Group, 2- (4-thiazolyl) ethyl group, 2- (5-thiazolyl) ethyl group, 2- (2-methyl-4-thiazolyl) ethyl group, 2- (2-methyl-5-thiazolyl) ethyl group, 2- (2,5-dimethyl-4-thiazolyl) ethyl group, 2- (2,4-dimethyl-5-thiazolyl) ethyl group, 2- (2-methyl-5-phenyl) -4-thiazolyl) ethyl group, 2- (2-methyl-4-phenyl-5-thiazolyl) ethyl group, 2- (2-phenyl-4-thiazolyl) ethyl group, 2- (2-phenyl-5-thiazolyl) ) Ethyl group, 2- (2-phenyl-5-methyl-4-thiazolyl) ethyl group, 3- (2-thiazolyl) propyl group, 2- (4-thiazolyl) propyl group, 3- (5-thiazolyl) propyl Group, 3- (2-methyl-4-thiazolyl) propyl group, 2- (2-methyl-5-thiazolyl) propyl group, 3- (2,5-dimethyl-4-thiazolyl) propyl group, 3- (2 , 4-Dimethyl-5-thiazolyl) propyl group, 3- (2-methyl-5-phenyl-4-thiazolyl) propyl group, 3- (2-methyl-4-phenyl-5-thiazolyl) propyl group, 2- (2-F Enyl-4-thiazolyl) propyl group, 3- (3-phenyl-5-thiazolyl) propyl group, 3- (2-phenyl-5-methyl-4-thiazolyl) propyl group, 4- (2-thiazolyl) butyl group 4- (4-thiazolyl) butyl group, 3- (5-thiazolyl) butyl group, 4- (2-methyl-4-thiazolyl) butyl group, 4- (2-methyl-5-thiazolyl) butyl group, 4 -(2,5-dimethyl-4-thiazolyl) butyl group, 4- (2,4-dimethyl-5-thiazolyl) butyl group, 4- (2-methyl-5-phenyl-4-thiazolyl) butyl group, 4 -(2-methyl-4-phenyl-5-thiazolyl) butyl group, 4- (2-phenyl-4-thiazolyl) butyl group, 4- (4-phenyl-5-thiazolyl) butyl group, 4- (2- Phenyl-5-methyl 4-thiazolyl) butyl group, 5- (2-thiazolyl) pentyl group, 5- (4-thiazolyl) pentyl group, 5- (5-thiazolyl) pentyl group, 5- (2-methyl-4-thiazolyl) pentyl group 5- (2-methyl-5-thiazolyl) pentyl group, 5- (2,5-dimethyl-4-thiazolyl) pentyl group, 5- (2,4-dimethyl-5-thiazolyl) pentyl group, 5- ( 2-methyl-5-phenyl-4-thiazolyl) pentyl group, 5- (2-methyl-4-phenyl-5-thiazolyl) pentyl group, 5- (2-phenyl-4-thiazolyl) pentyl group, 5- ( 4-phenyl-5-thiazolyl) pentyl group, 5- (2-phenyl-5-methyl-4-thiazolyl) pentyl group, 6- (2-thiazolyl) hexyl group, 6- (4-thiazolyl) hexyl 6- (5-thiazolyl) hexyl, 6- (2-methyl-4-thiazolyl) hexyl, 6- (2-methyl-5-thiazolyl) hexyl, 6- (2,5-dimethyl-4- Thiazolyl) hexyl group, 6- (2,4-dimethyl-5-thiazolyl) hexyl group, 6- (2-methyl-5-phenyl-4-thiazolyl) hexyl group, 6- (2-methyl-4-phenyl-) 5-thiazolyl) hexyl group, 6- (2-phenyl-4-thiazolyl) hexyl group, 6- (4-phenyl-5-thiazolyl) hexyl group, 6- (2-phenyl-5-methyl-4-thiazolyl) Hexyl group, 2- (2,3-dimethylphenyl) -4-thiazolylmethyl group, 2- (3-methylphenyl) -5-thiazolylmethyl group, 2- (3-trifluoromethylphenyl) -5-methyl Ru-4-thiazolylmethyl group, 2- (3-ethylphenyl) -4-methyl-5-thiazolylmethyl group, 2- (2-trifluoroethylphenyl) -4-methyl-5-thiazolylmethyl group, 2-methyl-5 A thiazolyl-substituted C1-6 alkyl group such as-(2,4,6-trimethylphenyl) -4-thiazolylmethyl group [on the thiazole ring, a C1-6 alkyl group and a phenyl group (on the phenyl ring, a halogen atom and 1 to 5 groups selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkyl groups, and preferably 1 to 2 groups selected from the group consisting of 1 to 2 groups may be substituted. May be substituted.].

  Examples of the tetrazolyl-substituted C1-6 alkyl group [at least one C1-6 alkyl group may be substituted on the tetrazole ring] include 5- (1H) -tetrazolylmethyl group, 2- (5- (1H) -tetrazolyl) ethyl group, 1- (5- (1H) -tetrazolyl) ethyl group, 3- (5- (1H) -tetrazolyl) propyl group, 4- (5- (1H) -tetrazolyl) ) Butyl group, 5- (5- (1H) -tetrazolyl) pentyl group, 6- (5- (1H) -tetrazolyl) hexyl group, 2-methyl-3- (5- (1H) -tetrazolyl) propyl group, 1,1-dimethyl-2- (5- (1H) -tetrazolyl) ethyl group, 1-methyl-5- (1H) -tetrazolylmethyl group, 1-ethyl-5- (1H) -tetrazolylmethyl Group, 1-n-pro Ru-5- (1H) -tetrazolylmethyl group, 1-n-butyl-5- (1H) -tetrazolylmethyl group, 1-n-pentyl-5- (1H) -tetrazolylmethyl group, 1-n-hexyl-5- (1H) -tetrazolylmethyl group, 2- (1-methyl-5- (1H) -tetrazolyl) ethyl group, 2- (1-ethyl-5- (1H) -tetrazolyl ) Ethyl group, 2- (1-n-propyl-5- (1H) -tetrazolyl) ethyl group, 2- (1-n-butyl-5- (1H) -tetrazolyl) ethyl group, 2- (1-n Tetrazolyl-substituted C1-6 alkyl groups such as -pentyl-5- (1H) -tetrazolyl) ethyl group, 2- (1-n-hexyl-5- (1H) -tetrazolyl) ethyl group [on the tetrazole ring, 1 C1-6 alkyl groups may be substituted] It can be mentioned.

  Examples of the isoxazolyl-substituted C1-6 alkyl group [at least one C1-6 alkyl group may be substituted on the isoxazole ring] include, for example, (3-, 4- or 5-isoxazolyl) methyl group 2- (3-, 4- or 5-isoxazolyl) ethyl group, 1- (3-, 4- or 5-isoxazolyl) ethyl group, 3- (3-, 4- or 5-isoxazolyl) propyl group, 4 -(3-, 4- or 5-isoxazolyl) butyl group, 5- (3-, 4- or 5-isoxazolyl) pentyl group, 6- (3-, 4- or 5-isoxazolyl) hexyl group, 3-methyl -2- (3-, 4- or 5-isoxazolyl) propyl group, 1,1-dimethyl-2- (3-, 4- or 5-isoxazolyl) ethyl group, (3-methyl-4-isoo (Sazolyl) methyl group, (4-ethyl-3-isoxazolyl) methyl group, (5-n-propyl-3-isoxazolyl) methyl group, (4-n-butyl-5-isoxazolyl) methyl group, (5-n- Pentyl-3-isoxazolyl) methyl group, (3-n-hexyl-4-isoxazolyl) methyl group, (3,4-dimethyl-5-isoxazolyl) methyl group, 2- (3-methyl-4-isoxazolyl) ethyl group 1- (4-ethyl-3-isoxazolyl) ethyl group, 3- (5-n-propyl-3-isoxazolyl) propyl group, 4- (4-n-butyl-5-isoxazolyl) butyl group, 5- ( 5-n-pentyl-3-isoxazolyl) mepentyl group, 6- (3-n-hexyl-4-isoxazolyl) hexyl group, 2- (3 - [On isoxazole ring, Cl to 6 alkyl groups may be one or two substituted] isoxazolyl substituted Cl to 6 alkyl group such as dimethyl-5-isoxazolyl) ethyl group can be exemplified.

  1,2,4-oxadiazolyl-substituted C1-6 alkyl group [At least one phenyl group is substituted on the 1,2,4-oxadiazole ring (the C1-6 alkyl group is substituted on the phenyl ring) May be substituted), for example, (3- or 5-) 1,2,4-oxadiazolylmethyl group, 2-[(3- or 5-) 1,2 , 4-oxadiazolyl] ethyl group, 1-[(3- or 5-) 1,2,4-oxadiazolyl] ethyl group, 3-[(3- or 5-) 1,2,4-oxadiazolyl] propyl group, 4-[(3- or 5-) 1,2,4-oxadiazolyl] butyl group, 5-[(3- or 5-) 1,2,4-oxadiazolyl] pentyl group, 6-[(3- or 5 -) 1,2,4-oxadiazolyl] hexyl group, 3-methyl-2- (3- or 5-) 1,2,4-oxadiazolyl] propyl group, 1,1-dimethyl-2-[(3- or 5-) 1,2,4-oxadiazolyl] ethyl group, (3-phenyl- 5-1,2,4-oxadiazolyl) methyl group, (5-phenyl-3-1,2,4-oxadiazolyl) methyl group, [3- (3-methylphenyl) -5-1,2,4-oxadiazolyl ] Methyl group, [5- (3,4-dimethylphenyl) -3-1,2,4-oxadiazolyl]] methyl group, [3- (2,4,6-trimethylphenyl) -5-1,2 , 4-oxadiazolyl] methyl group, [5- (2-ethylphenyl) -3-1,2,4-oxadiazolyl] methyl group, 2-[(3-n-propylphenyl) -5-1,2,4. -Oxadiazolyl] ethyl group, 1- [5 (4-n-butylphenyl) -3-1,2,4-oxadiazolyl] ethyl group, 3- [3- (3-n-pentylphenyl) -5-1,2,4-oxadiazolyl]] propyl group, 4- [5- (5-n-hexylphenyl) -3-1,2,4-oxadiazolyl]] butyl group, 5- [3- (3-ethyl-4-methylphenyl) -5-1,2, 1,2,4-oxadiazolyl-substituted C1-6 alkyl group [1 , 2,4-oxadiazole ring may be substituted with one phenyl group (on the phenyl ring, 1 to 3 C1-6 alkyl groups may be substituted). ] Can be mentioned.

  Examples of the benzofurazanyl-substituted C1-6 alkyl group include 4-benzofurazanylmethyl, 5-benzofurazanylmethyl, 6-benzofurazanylmethyl, 7-benzofurazanylmethyl, 1- (4-benzofurazanyl). ) Ethyl, 2- (5-benzofurazanyl) ethyl, 3- (6-benzofurazanyl) propyl, 4- (7-benzofurazanyl) butyl, 5- (4-benzofurazanyl) pentyl, 6- (5-benzofurazanyl) hexyl, 2- Examples include methyl-3- (6-benzofurazanyl) propyl and 1,1-dimethyl-2- (7-benzofurazanyl) ethyl groups.

  Phenylamino group [C 1-6 alkyl group may be substituted at the N-position of the phenylamino group, and at least one halogen-substituted or unsubstituted C1-6 alkoxy group is present on the phenyl ring of the phenylamino group. May be substituted] as an unsubstituted phenylamino group (also known as anilino group) or a phenylamino group substituted with 1 to 3 halogen-substituted or unsubstituted C1-6 alkoxy groups as defined above. For example, phenylamino group, 2-methoxyphenylamino group, 3-methoxyphenylamino group, 4-methoxyphenylamino group, 2-ethoxyphenylamino group, 3-ethoxyphenylamino group, 4-ethoxyphenylamino group 4-n-propoxyphenylamino group, 4-tert-butoxyphenylamino group, 4-n-butyl Xiphenylamino group, 2-trifluoromethoxylphenylamino group, 3-trifluoromethoxylphenylamino group, 4-trifluoromethoxyphenylamino group, 2-pentafluoroethoxyphenylamino group, 3-pentafluoroethoxyphenylamino group, 2,3-dimethoxylphenylamino group, 3,4,5-trimethoxyphenylamino group, 4-n-pentyloxyphenylamino group, 4-n-hexyloxyphenylamino group, 3,5-ditrifluoromethoxyphenyl Amino group, N-phenyl-N-methylamino group, N- (2-methoxyphenyl) -N-ethylamino group, N- (3-methoxyphenyl) -Nn-propylamino group, N- (4- Methoxyphenyl) -Nn-butylamino group, N- (2-ethoxyphene) ) -Nn-pentylamino group, N- (3-ethoxyphenyl) -Nn-hexylamino group, N- (4-ethoxyphenyl) -N-methylamino group, N- (4-n- Propoxyphenyl) -N-ethylamino group, N- (4-tert-butoxyphenyl) -Nn-propylamino group, N- (4-n-butoxyphenyl) -Nn-butylamino group, N- (2-trifluoromethoxyphenyl) -Nn-pentylamino group, N- (3-trifluoromethoxyphenyl) -Nn-hexylamino group, N- (4-trifluoromethoxyphenyl) -N-methyl Amino group, N- (2-pentafluoroethoxyphenyl) -N-ethylamino group, N- (3-pentafluoroethoxyphenyl) -Nn-propylamino group, N- (2,3-di Methoxyphenyl) -N-methylamino group, N- (3,4,5-trimethoxyphenyl) -N-methylamino group, N- (4-n-pentyloxyphenyl) -N-methylamino group, N- (4-n-hexyloxyphenyl) -N-methylamino group, N- (3,5-ditrifluoromethoxyphenyl) -N-methylamino group and the like can be mentioned.

  Examples of the phenoxy group (which may be substituted with a halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring) include, for example, a phenoxy group, 2-methoxyphenoxy group, 3-methoxyphenoxy group, 4- Methoxyphenoxy group, 4-isopropoxyphenoxy group, 4-n-butoxyphenoxy group, 2,4-dimethoxyphenoxy group, 2,3-dimethoxyphenoxy group, 2,3,4,5,6-pentamethoxyphenoxy group, 3,5-dimethoxyphenoxy group, 2,5-dimethoxyphenoxy group, 2,4,6-trimethoxyphenoxy group, 3,5-di (trifluoromethoxy) phenoxy group, 4-methoxy-3-trifluoromethoxyphenoxy group Group, 2,6-dimethoxyphenoxy group, 2-trifluoromethoxyphenoxy group, 3-tri Fluoromethoxyphenoxy group, 4-trifluoromethoxyphenoxy group, 2,3-di (trifluoromethoxy) phenoxy group, 2,4-di (trifluoromethoxy) phenoxy group, 2-pentafluoroethoxyphenoxy group, 3- Pentafluoroethoxyphenoxy group, 4-pentafluoroethoxyphenoxy group, 2-isopropoxyphenoxy group, 3-isopropoxyphenoxy group, 4-isopropoxyphenoxy group, 2-tert-butoxyphenoxy group, 3-tert-butoxyphenoxy group 4-tert-butoxyphenoxy group, 2-sec-butoxyphenoxy group, 3-sec-butoxyphenoxy group, 4-sec-butoxyphenoxy group, 4-n-hexyloxyphenoxy group, 2-n-heptafluoropropoxyphenoxy Group, 3-n-heptafluoropropoxyphenoxy group, 4-n-heptafluoropropoxyphenoxy group and other phenoxy groups (on the phenyl ring, selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups 1 to 5 groups, preferably 1 to 3 groups may be substituted).

  An amino group (on the amino group, a C1-6 alkyl group and a phenyl group as a substituent [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of 6 alkoxy groups may be substituted], for example, an amino group , Methylamino group, dimethylamino group, ethylamino group, diethylamino group, n-propylamino group, n-butylamino group, n-pentylamino group, 3-n-hexylamino group, phenylamino group, (4-chlorophenyl) ) Amino group, (4-bromophenyl) amino group, (2,4-dichlorophenyl) amino group, (2,4,6-trichlorophenyl) Mino group, (2,3,4,5,6-pentafluorophenyl) amino group, (4-fluorophenyl) amino group, (4-iodophenyl) amino group, (4-chlorophenyl) amino group, (3- Methylphenyl) amino group, (4-trifluoromethylphenyl) amino group, (4-trifluoromethylphenyl) amino group, 3- (4-trifluoromethylphenyl) amino group, (3,4-dimethylphenyl) amino Group, (3,4,5-trimethylphenyl) amino group, (2-methoxyphenyl) amino group, (4-trifluoromethoxyphenyl) amino group, 3- (4-trifluoromethoxyphenyl) amino group, (3 , 5-Dimethoxyphenyl) amino group, (2,5-dimethoxyphenyl) amino group, (2,4,6-trimethoxyphenyl) amino N-methyl-N- (4-trifluoromethylphenyl) amino group, N-ethyl-N- (4-trifluoromethoxyphenyl) amino group and the like (on the amino group, C1 as a substituent) -6 alkyl group and phenyl group [on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is 1 to A group selected from the group consisting of 5 and preferably 1 to 3 groups may be substituted).

  Piperidyl group [on the piperidine ring, a phenoxy group (on the phenyl ring, a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted as a substituent) and an amino group (on the amino group, , C1-6 alkyl group and phenyl group as a substituent [on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one of the groups selected from the group consisting of: a group selected from the group consisting of: a group selected from the group consisting of: May be, for example, 2-piperidyl group, 3-piperidyl group, 4-piperidyl group, 2,4-diamino-1-piperidyl group, 2,4,6-tria No-1-piperidyl group, 4-amino-3-phenoxy-1-piperidyl group, 4-phenoxy-2-amino-1-piperidyl group, 2-amino-1-piperidyl group, 3-amino-1-piperidyl group 4-amino-1-piperidyl group, 4-methylamino-1-piperidyl group, 4-ethylamino-1-piperidyl group, 4-n-propylamino-1-piperidyl group, 4-dimethylamino-1-piperidyl group Group, 4-diethylamino-1-piperidyl group, 4-di-n-propylamino-1-piperidyl group, 4-phenylamino-1-piperidyl group, 4- (N-phenyl-N-methylamino) -1- Piperidyl group, 4- (2-fluorophenylamino) -1-piperidyl] group, 4- (3-fluorophenylamino) -1-piperidyl group, 4- (4-fluoro Enylamino) -1-piperidyl group, 4- (2-chlorophenylamino) -1-piperidyl group, 4- (3-chlorophenylamino) -1-piperidyl group, 4- (4-chlorophenylamino) -1-piperidyl group, 4- (2,3-dichlorophenylamino) -1-piperidyl group, 4- (2,4,6-trifluorophenylamino) -1-piperidyl group, 4- (2,4-dichlorophenylamino) -1-piperidyl group Group, 4- (3,4-dichlorophenylamino) -1-piperidyl group, 4- (3,5-dichlorophenylamino) -1-piperidyl group, 4- (2,3,4,5,6-pentafluorophenyl) Amino) -1-piperidyl group, 4- (2-trifluoromethylphenylamino) -1-piperidyl group, 4- (2-methylphenylamino) -1- Piperidyl group, 4- (2,3-dimethylphenylamino) -1-piperidyl group, 4- (2-trifluoromethylphenylamino) -1-piperidyl group, 4- (2,4,6-trimethylphenylamino) -1-piperidyl group, 4- (4-trifluoromethylphenylamino) -1-piperidyl group, 4- (2-pentafluoroethylphenylamino) -1-piperidyl group, 4- (3-pentafluoroethylphenylamino) ) -1-piperidyl group, 4- (4-pentafluoroethylphenylamino) -1-piperidyl group, 4- (2-trifluoromethoxyphenylamino) -1-piperidyl group, 4- (2-methoxyphenylamino) -1-piperidyl group, 4- (2,3-dimethoxyphenylamino) -1-piperidyl group, 4- (2,4,6-trimethyl) Xylphenylamino) -1-piperidyl group, 4- [N-methyl-N- (2,4,6-trimethoxyphenylamino)]-1-piperidyl group, 4- [N-methyl-N- (3 4-dimethylphenylamino)]-1-piperidyl group, 4- (3-trifluoromethoxyphenylamino) -1-piperidyl group, 4- (4-trifluoromethoxyphenylamino) -1-piperidyl group, 4- ( 2-pentafluoroethoxyphenylamino) -1-piperidyl group, 4- (3-pentafluoroethoxyphenylamino) -1-piperidyl group, 4- (4-pentafluoroethoxyphenylamino) -1-piperidyl group, 4- (2-fluorophenylamino) -1-piperidyl group, 4- (3-fluorophenylamino) -1-piperidyl group, 4- (4-fluoro Phenylamino) -1-piperidyl group, 4-phenoxy-1-piperidyl group, 2,4-diphenoxy-1-piperidyl group, 2,4,6-triphenoxy-1-piperidyl group, 4- (2-methoxyphenoxy) ) -1-piperidyl group, 1- (3-methoxyphenoxy) -4-piperidyl group, 1- (4-methoxyphenoxy) -4-piperidyl group, 2- (2-ethoxyphenoxy) -3-piperidyl group, 3 -(3-ethoxyphenoxy) -4-piperidyl group, 4- (4-ethoxyphenoxy) -5-piperidyl group, 3- (4-n-propoxyphenoxy) -2-piperidyl group, 2- (4-tert- Butoxyphenoxy) -1-piperidyl group, 1- (4-n-butoxyphenoxy) -2-piperidyl group, 2- (2-trifluoromethoxyphenoxy) ) -3-piperidyl group, 3- (3-trifluoromethoxyphenoxy) -4-piperidyl group, 4- (4-trifluoromethoxyphenoxy) -3-piperidyl group, 3- (2-pentafluoroethoxyphenoxy)- 2-piperidyl group, 6- (3-pentafluoroethoxyphenoxy) -1-piperidyl group, 1- (2,3-dimethoxyphenoxy) -4-piperidyl group, 4- (3,4,5-trimethoxyphenoxy) Piperidyl groups such as -1-piperidyl group, 4- (4-n-pentyloxyphenoxy group, 4- (4-n-hexyloxyphenoxy) -1-piperidyl group [on the piperidine ring, a phenoxy group (phenyl ring) Above, 1 to 5, preferably 1 to 3 halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted as a substituent. And an amino group (on the amino group, a C1-6 alkyl group and a phenyl group as a substituent [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted group) 1 to 5 groups, preferably 1 to 3 groups selected from the group consisting of C1-6 alkoxy groups, may be substituted with 1 to 2 groups selected from the group consisting of May be substituted with 1 to 3 groups selected from the group consisting of:

  Piperazinyl group [C1-6 alkoxycarbonyl group, phenyl C1-6 alkyl group on piperazine ring (halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted on phenyl ring) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted), phenyl C2-6 alkenyl groups (on the phenyl ring, halogen atoms, halogen substituted or unsubstituted C1-6 At least one selected from the group consisting of an alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted, and a benzoyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted A group consisting of a substituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group The group selected from the group consisting of at least one selected from the above group may be substituted] is, for example, (1-, 2- or 3 -) Piperazinyl group, 4-tert-butoxycarbonyl-1-piperazinyl group, 4-ethoxycarbonyl-1-piperazinyl group, 4-methoxycarbonyl-1-piperazinyl group, 2,4-dimethoxycarbonyl-1-piperazinyl group, 2 , 4,6-triethoxycarbonyl-1-piperazinyl group, 4- (4-trifluoromethoxybenzyl) -1-piperazinyl group, 4- (4-chlorobenzyl) -1-piperazinyl group, 4- (4-methoxy Benzyl) -1-piperazinyl group, 4- (4-bromobenzyl) -1-piperazinyl group, 4- (4-methylbenzyl) -1-piperazi 4- (2,4-dichlorobenzyl) -1-piperazinyl group, 4- (3,4-dimethoxybenzyl) -1-piperazinyl group, 4- (2,4,6-trifluorobenzyl) -1 -Piperazinyl group, 4- (3,4-dimethylbenzyl) -1-piperazinyl group, 4- (2,4,6-trimethoxybenzyl) -1-piperazinyl group, 4- (2,4,6-trimethylbenzyl) ) -1-piperazinyl group, 4- (4-iodobenzyl) -1-piperazinyl group, 4- (4-trifluoromethylbenzyl) -1-piperazinyl group, 4- (3,4-dichlorobenzyl) -1- Piperazinyl group, 4- [3- (4-trifluoromethylphenyl) -2-propenyl] -1-piperazinyl group, 4- [3- (4-trifluoromethylphenyl) -2-propenyl] -1 -Piperazinyl group, 4- (4-trifluoromethylbenzoyl) -1-piperazinyl group, 4- [3- (4-chlorophenyl) -2-propenyl] -1-piperazinyl group, 4- [3- (4-methyl) Phenyl) -2-propenyl] -1-piperazinyl group, 4- [3- (4-methoxyphenyl) -2-propenyl] -1-piperazinyl group, 4- [3- (3,4-dimethylphenyl) -2 -Propenyl] -1-piperazinyl group, 4- [3- (3,4-dimethoxyphenyl) -2-propenyl] -1-piperazinyl group, 4- [3- (3,4,5-trimethylphenyl) -2 -Propenyl] -1-piperazinyl group, 4- [3- (3,4,5-trimethoxyphenyl) -2-propenyl] -1-piperazinyl group, 4- [3- (3,4-dichlorophenyl)- -Propenyl] -1-piperazinyl group, 4- [3- (2,4,6-trifluorophenyl) -2-propenyl] -1-piperazinyl group, 4- [3- (4-iodophenyl) -2- Propenyl] -1-piperazinyl group, 4- [3- (3-bromophenyl) -2-propenyl] -1-piperazinyl group, 4- (4-fluorobenzyl) -1-piperazinyl group, 4- (4-methyl) Benzoyl) -1-piperazinyl group, 4- (4-methoxybenzoyl) -1-piperazinyl group, 4- (3,4-dimethylbenzoyl) -1-piperazinyl group, 4- (2,4-dimethoxybenzoyl) -1 -Piperazinyl group, 4- (3,4,5-trimethylbenzoyl) -1-piperazinyl group, 4- (2,4,6-trimethoxybenzoyl) -1-piperazinyl group, 4- ( -Chlorobenzoyl) -1-piperazinyl group, 4- (2,4,6-trifluorobenzoyl) -1-piperazinyl group, 4- (4-bromobenzoyl) -1-piperazinyl group, 4- (4-iodobenzoyl) ) -1-piperazinyl group, 4- (3,4-dichlorobenzoyl) -1-piperazinyl group, 4- (4-fluorobenzoyl) -1-piperazinyl group, 4-benzyl-3- (3-phenyl-2-) Propenyl) -1-piperazinyl group, piperazinyl group such as 4-benzoyl-3,5-dibenzyl-1-piperazinyl group [on piperazine ring, C1-6 alkoxycarbonyl group, phenyl C1-6 alkyl group (on phenyl ring) Include a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy. 1 to 5, preferably 1 to 3 groups selected from the group consisting of silyl groups, phenyl C2-6 alkenyl groups (unsubstituted or halogen atoms, halogen substituted or unsubstituted C1 1 to 2 and preferably 1 to 2 substituted phenyl groups having 1 to 5, preferably 1 to 3 groups selected from 6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups. It is a group composed of alkenyl groups having 1 to 3 bonds. ) And a benzoyl group (on the phenyl ring, 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) , Preferably 1 to 3 groups may be substituted), and 1 to 3 groups selected from the group consisting of may be substituted.

  Homopiperazinyl group [C1-6 alkoxycarbonyl group and phenyl C1-6 alkyl group on homopiperazine ring (halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted on phenyl ring) The group selected from the group consisting of at least one group selected from the group consisting of C1-6 alkoxy groups may be substituted], for example, (1-, 2-, 3-, 4-, 5-, 6- or 7-) homopiperazinyl group, 3,4-dibenzyl-1-homopiperazinyl group, 2,7-dibenzyl-1-homopiperazinyl group, 2, 3,4-tribenzyl-1-homopiperazinyl group, 2,4,6-tribenzyl-1-homopiperazinyl group, 4-benzyl-1-homopiperazinyl group 4- (2-phenethyl) -1-homopiperazinyl group, 4- (3-phenylpropyl) -1-homopiperazinyl group, 4- (4-phenylbutyl) -1-homopiperazinyl group, 4- (5-phenylpentyl) -1-homopiperazinyl group, 4- (6-phenylhexyl) -1-homopiperazinyl group, 4- (2-fluorobenzyl) -1-homopiperazinyl group, 4- (3-fluorobenzyl) -1-homopiperazinyl group, 4- (4-fluorobenzyl) -1-homopiperazinyl group, 4- (2-chlorobenzyl) -1-homopiperazinyl group, 4- (3-chlorobenzyl) -1-homopiperazinyl group, 4- (4-chlorobenzyl) -1 -Homopiperazinyl group, 4- (2,3-dichlorobenzyl) -1-homopiperazinyl group, 4- (2,4-dichlorobe Gil) -1-homopiperazinyl group, 4- (3,4-dichlorobenzyl) -1-homopiperazinyl group, 4- (3,5-dichlorobenzyl) -1-homopiperazinyl group, 4- (3,4,5-trichloro) (Benzyl) -1-homopiperazinyl group, 4- (2,3,4,5,6-pentafluorobenzyl) -1-homopiperazinyl group, 4- (2-trifluoromethylbenzyl) -1-homopiperazinyl group, 4- ( 3-trifluoromethylbenzyl) -1-homopiperazinyl group, 4- (4-trifluoromethylbenzyl) -1-homopiperazinyl group, 4- (4-methylbenzyl) -1-homopiperazinyl group, 4- (3,4- Dimethylbenzyl) -1-homopiperazinyl group, 4- (2,4,6-trimethylbenzyl) -1-homopiperazinyl group, 4- (2-pep N-fluoroethylbenzyl) -1-homopiperazinyl group, 4- (3-pentafluoroethylbenzyl) -1-homopiperazinyl group, 4- (4-pentafluoroethylbenzyl) -1-homopiperazinyl group, 4- (2-trifluoro) Methoxybenzyl) -1-homopiperazinyl group, 4- (3-trifluoromethoxybenzyl) -1-homopiperazinyl group, 4- (4-trifluoromethoxybenzyl) -1-homopiperazinyl group, 4- (4-methoxybenzyl)- 1-homopiperazinyl group, 4- (3,4-dimethoxybenzyl) -1-homopiperazinyl group, 4- (2,4,6-trimethoxybenzyl) -1-homopiperazinyl group, 4- (2-pentafluoroethoxybenzyl) -1-homopiperazinyl group, 4- (3-pentafluoroethoxybenzene) Di) -1-homopiperazinyl group, 4- (4-pentafluoroethoxybenzyl) -1-homopiperazinyl group, 4- [2- (4-trifluoromethoxyphenyl) ethyl] -1-homopiperazinyl group, 4- [3- (4-trifluoromethoxyphenyl) propyl] -1-homopiperazinyl group, 4- [4- (4-trifluoromethoxyphenyl) butyl] -1-homopiperazinyl group, 4- [5- (4-trifluoromethoxyphenyl) Pentyl] -1-homopiperazinyl group, 4- [6- (4-trifluoromethoxyphenyl) hexyl] -1-homopiperazinyl group, 4- [2- (4-trifluoromethylphenyl) ethyl] -1-homopiperazinyl group, 4- [3- (4-trifluoromethylphenyl) propyl] -1-homopiperazinyl group, -[4- (4-trifluoromethylphenyl) butyl] -1-homopiperazinyl group, 4- [5- (4-trifluoromethylphenyl) pentyl] -1-homopiperazinyl group, 4- [6- (4-tri Fluoromethylphenyl) hexyl] -1-homopiperazinyl group, 4-tert-butoxycarbonyl- (1-, 2-, 3-, 5-, 6- or 7-) homopiperazinyl group, 4-methoxycarbonyl (1-, 2) -, 3-, 5-, 6- or 7-) homopiperazinyl group, 4-ethoxycarbonylcarbonyl- (1-, 2-, 3-, 5-, 6- or 7-) homopiperazinyl group such as homopiperazinyl group [homo On the piperazine ring, a C1-6 alkoxycarbonyl group and a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, halogen-substituted or non-placed 1 to 5, preferably 1 to 3 groups selected from the group consisting of a substituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. 1 to 3 selected groups may be substituted].

  Examples of the phenoxy-substituted phenyl group (at least one halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted on the phenyl ring) include, for example, a 2-phenoxyphenyl group, 2,3-di Phenoxyphenyl group, 2,4,6-triphenoxyphenyl group, 3- (2-methoxyphenoxy) phenyl group, 4- (3-methoxyphenoxy) phenyl group, 2- (4-methoxyphenoxy) phenyl group, 3- (4-isopropoxyphenoxy) phenyl group, 4- (4-n-butoxyphenoxy) phenyl group, 2- (2,4-dimethoxyphenoxy) phenyl group, 3- (2,3-dimethoxyphenoxy) phenyl group, 4 -(2,3,4,5,6-pentamethoxyphenoxy) phenyl group, 2- (3,5-dimethoxyphenoxy) pheny Group, 3- (2,5-dimethoxyphenoxy) phenyl group, 4- (2,4,6-trimethoxyphenoxy) phenyl group, 2- [3,5-di (trifluoromethoxy) phenoxy] phenyl group, 3 -(4-methoxy-3-trifluoromethoxyphenoxy) phenyl group, 4- (2,6-dimethoxyphenoxy) phenyl group, 2- (2-trifluoromethoxyphenoxy) phenyl group, 3- (3-trifluoromethoxy) Phenoxyphenyl group, 4- (4-trifluoromethoxyphenoxy) phenyl group, 2- [2,3-di (trifluoromethoxy) phenoxy] phenyl group, 3- [2,4-di (trifluoromethoxy) phenoxy] Phenyl group, 4- (2-pentafluoroethoxyphenoxy) phenyl group, 2- (3-pentafluoroethoxyphenyl) Noxy) phenyl group, 3- (4-pentafluoroethoxyphenoxy) phenyl group, 4- (2-isopropoxyphenoxy) phenyl group, 2- (3-isopropoxyphenoxy) phenyl group, 3- (4-isopropoxyphenoxy) ) Phenyl group, 4- (2-tert-butoxyphenoxy) phenyl group, 2- (3-tert-butoxyphenoxy) phenyl group, 3- (4-tert-butoxyphenoxy) phenyl group, 4- (2-sec- Butoxyphenoxy) phenyl group, 3- (3-sec-butoxyphenoxy) phenyl group, 4- (4-sec-butoxyphenoxy) phenyl group, 2- (4-n-hexyloxyphenoxy) phenyl group, 3- (2 -N-heptafluoropropoxyphenoxy) phenyl group, 4- (3-n-heptafluoro) Phenoxy-substituted phenyl groups such as lopropoxyphenoxy) phenyl group and 2- (4-n-heptafluoropropoxyphenoxy) phenyl group (on the phenyl ring, preferably 1 to 5, preferably 1 to 3 halogen-substituted or And a substituted C1-6 alkoxy group may be substituted).

  Phenoxy group [on the phenyl ring, a halogen-substituted or unsubstituted C1-6 alkoxy group and a phenoxy-substituted phenyl group (on the phenyl ring, at least one halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. May be substituted with at least one group selected from the group consisting of: a phenoxy group, a 2-methoxyphenoxy group, a 3-methoxyphenoxy group, and a 4-methoxyphenoxy group. 4-isopropoxyphenoxy group, 4-n-butoxyphenoxy group, 2,4-dimethoxyphenoxy group, 2,3-dimethoxyphenoxy group, 2,3,4,5,6-pentamethoxyphenoxy group, 3,5 -Dimethoxyphenoxy group, 2,5-dimethoxyphenoxy group, 2,4,6-trimethoxyphenoxy group, 3, -Di (trifluoromethoxy) phenoxy group, 4-methoxy-3-trifluoromethoxyphenoxy group, 2,6-dimethoxyphenoxy group, 2-trifluoromethoxyphenoxy group, 3-trifluoromethoxyphenoxy group, 4-trifluoro Methoxyphenoxy group, 2,3-di (trifluoromethoxy) phenoxy group, 2,4-di (trifluoromethoxy) phenoxy group, 2-pentafluoroethoxyphenoxy group, 3-pentafluoroethoxyphenoxy group, 4-pentafluoro Ethoxyphenoxy group, 2-isopropoxyphenoxy group, 3-isopropoxyphenoxy group, 4-isopropoxyphenoxy group, 2-tert-butoxyphenoxy group, 3-tert-butoxyphenoxy group, 4-tert-butoxyphenoxy group, 2 − ec-butoxyphenoxy group, 3-sec-butoxyphenoxy group, 4-sec-butoxyphenoxy group, 4-n-hexyloxyphenoxy group, 2-n-heptafluoropropoxyphenoxy group, 3-n-heptafluoropropoxyphenoxy group 4-n-heptafluoropropoxyphenoxy group, 2- (2-phenoxyphenyl) phenoxy group, 2,3-di (2-phenoxyphenyl) phenoxy group, 2,3-di (2-phenoxyphenyl) -4- Methoxyphenoxy group, 2,4-dimethoxy-3- (3-phenoxyphenyl) phenoxy group, 3- (2,3-diphenoxyphenyl) phenoxy group, 4- (2,4,6-triphenoxyphenyl) phenoxy group 2- [3- (2-methoxyphenoxy) phenyl] phenoxy group, 3- [4 -(3-methoxyphenoxy) phenyl] phenoxy group, 4- [2- (4-methoxyphenoxy) phenyl] phenoxy group, 2- [3- (4-isopropoxyphenoxy) phenyl] phenoxy group, 3- [4- (4-n-butoxyphenoxy) phenyl] phenoxy group, 4- [2- (2,4-dimethoxyphenoxy) phenyl] phenoxy group, 2- [3- (2,3-dimethoxyphenoxy) phenyl] phenoxy group, 3 -[4- (2,3,4,5,6-pentamethoxyphenoxy) phenyl] phenoxy group, 4- [2- (3,5-dimethoxyphenoxy) phenyl] phenoxy group, 2- [3- (2, 5-dimethoxyphenoxy) phenyl] phenoxy group, 3- [4- (2,4,6-trimethoxyphenoxy) phenyl] phenoxy group, 4- { -[3,5-di (trifluoromethoxy) phenoxy] phenyl} phenoxy group, 2- [3- (4-methoxy-3-trifluoromethoxyphenoxy) phenyl] phenoxy group, 3- [4- (2,6 -Dimethoxyphenoxy) phenyl] phenoxy group, 4- [2- (2-trifluoromethoxyphenoxy) phenyl] phenoxy group, 2- [3- (3-trifluoromethoxyphenoxy) phenyl] phenoxy group, 3- [4- (4-trifluoromethoxyphenoxy) phenyl] phenoxy group, 4- {2- [2,3-di (trifluoromethoxy) phenoxy] phenyl} phenoxy group, 2- {3- [2,4-di (trifluoro) Methoxy) phenoxy] phenyl} phenoxy group, 3- [4- (2-pentafluoroethoxyphenoxy) phenyl Phenoxy group, 4- [2- (3-pentafluoroethoxyphenoxy) phenyl] phenoxy group, 2- [3- (4-pentafluoroethoxyphenoxy) phenyl] phenoxy group, 3- [4- (2-isopropoxyphenoxy) ) Phenyl] phenoxy group, 4- [2- (3-isopropoxyphenoxy) phenyl] phenoxy group, 2- [3- (4-isopropoxyphenoxy) phenyl] phenoxy group, 3- [2- (2-tert- Butoxyphenoxy) phenyl] phenoxy group, 4- [2- (3-tert-butoxyphenoxy) phenyl] phenoxy group, 2- [3- (4-tert-butoxyphenoxy) phenyl] phenoxy group, 3- [4- ( 2-sec-butoxyphenoxy) phenyl] phenoxy group, 2- [2- (3-sec-buto Xylphenoxy) phenyl] phenoxy group, 2- [3- (4-sec-butoxyphenoxy) phenyl] phenoxy group, 4- [2- (4-n-hexyloxyphenoxy) phenyl] phenoxy group, 2- [3- (2-n-heptafluoropropoxyphenoxy) phenyl] phenoxy group, 3- [4- (3-n-heptafluoropropoxyphenoxy) phenyl] phenoxy group, 4- [2- (4-n-heptafluoropropoxyphenoxy) Phenoxy groups such as phenyl] phenoxy group [on the phenyl ring, halogen-substituted or unsubstituted C1-6 alkoxy groups and phenoxy-substituted phenyl groups (on the phenyl ring, preferably 1-5, preferably 1-3 Selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups which may be substituted) Groups 1-5 was, preferably can be mentioned may have 1 to 3 substituents.

  Homopiperazinyl group (on homopiperazine ring, C1-6 alkoxycarbonyl group, phenyl C1-6 alkyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted], a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group And at least one group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted], a phenyl C1-6 alkoxycarbonyl group [on the phenyl ring, a halogen atom, Halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkyl At least one group selected from the group consisting of a xy group may be substituted], a phenylcarbamoyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted group] Or at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted], phenyl C2-6 alkenyl groups [on the phenyl ring, halogen atoms, halogen substituted or unsubstituted At least one group selected from the group consisting of a substituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] and a benzoyl group [on the phenyl ring, An atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; The group selected from the group consisting of at least one group selected from the group may be substituted]. For example, (1-, 2-, 3-, 4-, 5-, 6- or 7-) homopiperazinyl group, 4-tert-butoxycarbonyl-1-homopiperazinyl group, 4-ethoxycarbonyl-1-homopiperazinyl group, 4-methoxycarbonyl-1-homopiperazinyl group, 2,4-dimethoxycarbonyl-1-homopiperazinyl group, 2,4,6-triethoxycarbonyl-1-homopiperazinyl group, 4- (4-trifluoromethoxybenzyl) -1-homopiperazinyl group, 4- (4-chlorobenzyl) ) -1-Homopiperazinyl group, 4- (4-methoxybenzyl) -1-homopiperazinyl group, 4- (4-bromobenzyl) -1-homopiperazinyl group, 4- (4-methylbenzyl) -1-homopiperazinyl group, 4- (2,4-dichlorobenzyl) -1-homopiperazinyl group, 4- (3,4-dimethoxybenzyl) -1-homopiperazinyl group Group, 4- (2,4,6-trifluorobenzyl) -1-homopiperazinyl group, 4- (3,4-dimethylbenzyl) -1-homopiperazinyl group, 4- (2,4,6-trimethoxybenzyl) -1-homopiperazinyl group, 4- (2,4,6-trimethylbenzyl) -1-homopiperazinyl group, 4- (4-iodobenzyl) -1-homopiperazinyl group, 4- (4-trifluoromethylbenzyl) -1 -Homopiperazinyl group, 4- (3,4-dichlorobenzyl) -1-homopiperazinyl group, 4- [3- (4-trifluoromethylphenyl) 2-propenyl] -1-homopiperazinyl group, 4- [3- (4-trifluoromethylphenyl) -2-propenyl] -1-homopiperazinyl group, 4- (4-trifluoromethylbenzoyl) -1-homopiperazinyl group, 4- [3- (4-chlorophenyl) -2-propenyl] -1-homopiperazinyl group, 4- [3- (4-methylphenyl) -2-propenyl] -1-homopiperazinyl group, 4- [3- (4 -Methoxyphenyl) -2-propenyl] -1-homopiperazinyl group, 4- [3- (3,4-dimethylphenyl) -2-propenyl] -1-homopiperazinyl group, 4- [3- (3,4-dimethoxy) Phenyl) -2-propenyl] -1-homopiperazinyl group, 4- [3- (3,4,5-trimethylphenyl) -2-propenyl] -1-homo Perazinyl group, 4- [3- (3,4,5-trimethoxyphenyl) -2-propenyl] -1-homopiperazinyl group, 4- [3- (3,4-dichlorophenyl) -2-propenyl] -1- Homopiperazinyl group, 4- [3- (2,4,6-trifluorophenyl) -2-propenyl] -1-homopiperazinyl group, 4- [3- (4-iodophenyl) -2-propenyl] -1-homopiperazinyl Group, 4- [3- (3-bromophenyl) -2-propenyl] -1-homopiperazinyl group, 4- (4-fluorobenzyl) -1-homopiperazinyl group, 4- (4-methylbenzoyl) -1-homopiperazinyl Group, 4- (4-methoxybenzoyl) -1-homopiperazinyl group, 4- (3,4-dimethylbenzoyl) -1-homopiperazinyl group, 4- (2,4- Dimethoxybenzoyl) -1-homopiperazinyl group, 4- (3,4,5-trimethylbenzoyl) -1-homopiperazinyl group, 4- (2,4,6-trimethoxybenzoyl) -1-homopiperazinyl group, 4- (4 -Chlorobenzoyl) -1-homopiperazinyl group, 4- (2,4,6-trifluorobenzoyl) -1-homopiperazinyl group, 4- (4-bromobenzoyl) -1-homopiperazinyl group, 4- (4-iodobenzoyl) ) -1-homopiperazinyl group, 4- (3,4-dichlorobenzoyl) -1-homopiperazinyl group, 4- (4-fluorobenzoyl) -1-homopiperazinyl group, 4-benzyl-3- (3-phenyl-2-) Propenyl) -1-homopiperazinyl group, 4-benzoyl-3,5-dibenzyl-1-homopiperazinyl group, 2 7-dibenzyl-4-phenyl-1-homopiperazinyl group, 4- (4-trifluoromethylphenyl) -1-homopiperazinyl group, 4- (4-trifluoromethoxyphenyl) -1-homopiperazinyl group, 4- (4- Chlorophenyl) -1-homopiperazinyl group, 4- (4-methoxyphenyl) -1-homopiperazinyl group, 4- (4-methylphenyl) -1-homopiperazinyl group, 4- (2,4-dimethoxyphenyl) -1-homopiperazinyl group Group, 4- (2,4-dimethylphenyl) -1-homopiperazinyl group, 4- (2,4,6-trimethoxyphenyl) -1-homopiperazinyl group, 4- (2,4,6-trimethylphenyl)- 1-homopiperazinyl group, 4- (3,4-dichlorophenyl) -1-homopiperazinyl group, 4- (2,4,6 Trifluorophenyl) -1-homopiperazinyl group, 4- (4-bromophenyl) -1-homopiperazinyl group, 4- (4-iodophenyl) -1-homopiperazinyl group, 4- (4-fluorophenyl) -1-homopiperazinyl group Group, 4- (4-trifluoromethoxybenzyloxycarbonyl) -1-homopiperazinyl group, 4- (4-chlorobenzyloxycarbonyl) -1-homopiperazinyl group, 4- (4-methoxybenzyloxycarbonyl) -1-homopiperazinyl group Group, 4- (4-bromobenzyloxycarbonyl) -1-homopiperazinyl group, 4- (4-methylbenzyloxycarbonyl) -1-homopiperazinyl group, 4- (2,4-dichlorobenzyloxycarbonyl) -1-homopiperazinyl group The group 4- (3,4-dimethoxybenzyl) Ruoxycarbonyl) -1-homopiperazinyl group, 4- (2,4,6-trifluorobenzyloxycarbonyl) -1-homopiperazinyl group, 4- (3,4-dimethylbenzyloxycarbonyl) -1-homopiperazinyl group, 4 -(2,4,6-trimethoxybenzyloxycarbonyl) -1-homopiperazinyl group, 4- (2,4,6-trimethylbenzyloxycarbonyl) -1-homopiperazinyl group, 4- (4-iodobenzyloxycarbonyl) -1-homopiperazinyl group, 4- (4-trifluoromethylbenzyloxycarbonyl) -1-homopiperazinyl group, 4- (3,4-dichlorobenzyloxycarbonyl) -1-homopiperazinyl group, 4- (4-trifluoromethoxy) Phenylcarbamoyl) -1-homopiperazinyl group, 4 (4-chlorophenylcarbamoyl) -1-homopiperazinyl group, 4- (4-methoxyphenylcarbamoyl) -1-homopiperazinyl group, 4- (4-bromophenylcarbamoyl) -1-homopiperazinyl group, 4- (4-methylphenylcarbamoyl) ) -1-homopiperazinyl group, 4- (2,4-dichlorophenylcarbamoyl) -1-homopiperazinyl group, 4- (3,4-dimethoxyphenylcarbamoyl) -1-homopiperazinyl group, 4- (2,4,6-tri Fluorophenylcarbamoyl) -1-homopiperazinyl group, 4- (3,4-dimethylphenylcarbamoyl) -1-homopiperazinyl group, 4- (2,4,6-trimethoxyphenylcarbamoyl) -1-homopiperazinyl group, 4- ( 2,4,6-trimethylphenylcarba Yl) -1-homopiperazinyl group, 4- (4-iodophenylcarbamoyl) -1-homopiperazinyl group, 4- (4-trifluoromethylphenylcarbamoyl) -1-homopiperazinyl group, 3,4-di (phenylcarbamoyl)- Homopiperazinyl groups such as 1-homopiperazinyl group, 4- [2- (4-trifluoromethylphenyl) ethyl] -1-homopiperazinyl group, 4- [3- (4-trifluoromethylphenyl) propyl] -1-homopiperazinyl group (On the homopiperazine ring, a C1-6 alkoxycarbonyl group, a phenyl C1-6 alkyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1 1 to 5 groups selected from the group consisting of -6 alkoxy groups are preferred 1 to 3 may be substituted], a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] 1 to 5, preferably 1 to 3 groups selected from the group consisting of: a phenyl C1-6 alkoxycarbonyl group [on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted 1 to 5, preferably 1 to 3 groups selected from the group consisting of a C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group], a phenylcarbamoyl group [phenyl On the ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group 1 to 5, preferably 1 to 3 selected groups], phenyl C2-6 alkenyl group [unsubstituted or halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted Or 1 to 5 groups selected from unsubstituted C1-6 alkoxy groups, preferably 1 to 2 substituted phenyl groups and 1 to 2 double bonds with 2 to 6 carbon atoms. It is a group composed of an alkenyl group. ] And a benzoyl group [on the phenyl ring, 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] , Preferably 1 to 3 groups may be substituted] may be substituted with 1 to 3 groups selected from the group consisting of:

  1,2,3,4-tetrahydroisoquinolyl group (on the 1,2,3,4-tetrahydroisoquinoline ring, at least one amino group [on the amino group is a phenyl C1-6 alkyl group (phenyl On the ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. And at least one group selected from the group consisting of C1-6 alkyl groups may be substituted], for example, 1,2,3,4-tetrahydro ( 1-, 2-, 3-, 4-, 5-, 6-, 7- or 8-) isoquinolyl group, 4,6-diamino-1,2,3,4-tetrahydro-2-isoquinolyl group, 4, 6,7-triamino-1,2 3,4-tetrahydro-2-isoquinolyl group, 7- [N-methyl-N- (4-trifluoromethoxybenzyl) amino] -1,2,3,4-tetrahydro-2-isoquinolyl group, 6- (4 -Trifluoromethoxyphenoxy) -1,2,3,4-tetrahydro-2-isoquinolyl group, 7- [N-methyl-N- (4-trifluoromethylbenzyl) amino] -1,2,3,4 Tetrahydro-2-isoquinolyl group, 7- [N-methyl-N- (4-chlorobenzyl) amino] -1,2,3,4-tetrahydro-2-isoquinolyl group, 7- [N- (4-chlorobenzyl) ) Amino] -1,2,3,4-tetrahydro-2-isoquinolyl group, 7- {N-methyl-N- [2,4,6-tri (trifluoromethoxy) benzyl] amino} -1,2, 3, 4 Tetrahydro-2-isoquinolyl group, 7- {N-methyl-N- [2,4-di (trifluoromethyl) benzyl] amino} -1,2,3,4-tetrahydro-2-isoquinolyl group, 7- [ 1,2,3,4-tetrahydroisoquinolyl groups such as N-methyl-N- (2,3-diiodobenzyl) amino] -1,2,3,4-tetrahydro-2-isoquinolyl group (1,1, 1 to 3 amino groups on the 2,3,4-tetrahydroisoquinolin ring [phenyl C 1-6 alkyl group on the amino group (halogen atom, halogen substituted or unsubstituted on the phenyl ring) 1 to 5, preferably 1 to 3 groups selected from the group consisting of a C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) and C1-6 alkyl Selected from the group consisting of groups 1 to 2 groups may be substituted] may be substituted).

  An oxazolyl group (on the oxazole ring, a phenyl group [on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; At least one of the groups may be substituted], a C1-6 alkyl group and a piperidyl group [on the piperidine ring at least one phenoxy group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted At least one group selected from the group consisting of a substituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted but may be substituted) May be substituted with at least one group selected from the group consisting of: (2-, 4- or 5-) oxazolyl group, 4- 4-chlorophenyl) -2-oxazolyl group, 4- (4-trifluoromethoxyphenyl) -2-oxazolyl group, 2- (4-trifluoromethylphenyl) -4-oxazolyl group, 4- (4-trifluoromethyl) Phenyl) -2-oxazolyl group, 2- (4-trifluoromethoxyphenyl) -4-oxazolyl group, 4- (3,4-dichlorophenyl) -2-oxazolyl group, 5- (4-bromophenyl) -2- Oxazolyl group, 4- (4-fluorophenyl) -2-oxazolyl group, 5- (4-iodophenyl) -2-oxazolyl group, 2- (2,4,6-trifluorophenyl) -4-oxazolyl group, 4- (4-methylphenyl) -2-oxazolyl group, 4- (3-methoxyphenyl) -2-oxazolyl group, 2- (3,4-dimethyl) Ruphenyl) -5-oxazolyl group, 4- (2,4-dimethoxyphenyl) -2-oxazolyl group, 4- (2,4,6-trimethylphenyl) -2-oxazolyl group, 4- (3,4,5 -Trimethoxyphenyl) -2-oxazolyl group, 4,5-diphenyl-2-oxazolyl group, 2,4-diphenyl-5-oxazolyl group, 4-methyl-5- [4- (4-trifluoromethoxyphenoxy) An oxazolyl group such as a-(1-, 2- or 3-) piperidyl] -2-oxazolyl group (on the oxazole ring, a phenyl group [on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 1 to 5 groups, preferably 1 to 3 groups selected from the group consisting of alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted], C1 6 alkyl group and piperidyl group [on the piperidine ring, 1 to 3 phenoxy groups (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 1 to 5 groups selected from the group consisting of 6 alkoxy groups, preferably 1 to 2 groups may be substituted, and 1 to 2 groups selected from the group consisting of May be substituted).

  Isoindolinyl group (on the isoindoline ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. As (optionally), for example, (1-, 2-, 4- or 5-) isoindolinyl group, 4-chloro- (1-, 2-, 3-, 5-, 6- or 7-)- Isoindolinyl group, 4-trifluoromethyl- (1-, 2-, 3-, 5-, 6- or 7-)-isoindolinyl group, 4-trifluoromethoxy- (1-, 2-, 3-, 5- , 6- or 7-)-isoindolinyl group, 5-methyl- (1-, 2-, 3-, 4-, 6- or 7-)-isoindolinyl group, 4-methoxy- (1-, 2-3, -, 5-, 6-, or 7-) Isoi Dorynyl group, 3,4-difluoro- (1-, 2-, 5-, 6- or 7-) isoindolinyl group, 4,5,6-trichloro (1-, 2-, 3- or 7-) isoindolinyl group 4,5-dimethyl (1-, 2-, 3-, 6- or 7-) isoindolinyl group, 4,5,6-trimethyl (1-, 2-, 3- or 7-) isoindolinyl group, 4, 5-dimethoxy (1-, 2-, 3-, 6- or 7-) isoindolinyl group, 4,5,6-trimethoxy (1-, 2-, 3- or 7-) isoindolinyl group, 1,1-dimethyl Isoindolinyl group such as -5-bromo- (2-, 3-, 4-, 6- or 7-) isoindolinyl group (on the isoindoline ring, a halogen atom, the above-mentioned halogen-substituted or unsubstituted C1-6 alkyl Group and halogen substituted or not Groups selected from the group consisting of C1~6 alkoxy group conversion can be cited also may) have been 1-3 substituents.

  Piperazinyl group [a group consisting of at least one phenyl group on the piperazine ring (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group) The group may be substituted with at least one kind selected from the above groups]. For example, (1-, 2- or 3-) piperazinyl group, 4-phenyl-1-piperazinyl Group, 2,4-diphenyl-1-piperazinyl group, 2,4,5-triphenyl-1-piperazinyl group, 4- (4-trifluoromethoxyphenyl) -1-piperazinyl group, 4- (4-trifluoro Methylphenyl) -1-piperazinyl group, (4-chlorophenyl-1-piperazinyl) methyl group, 4- (2,4-dichlorophenyl) -1-pipe Dinyl group, 4- (2,4,6-trifluorophenyl) -1-piperazinyl group, 2,4-di (trifluoromethyl) phenyl-1-piperazinyl group, 2,4,6-trifluoro (trifluoromethoxy) ) Piperazinyl group such as phenyl-1-piperazinyl group [on the piperazine ring, 1 to 3 phenyl groups (on the phenyl ring, halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or 1 to 5, preferably 1 to 3 groups selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted].

  Piperidyl group [selected from the group consisting of a phenoxy group on the piperidine ring (halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring) And at least one group selected from the group consisting of phenyl C1-6 alkyl groups may be substituted], for example, the piperidyl group [piperidine ring] Above, at least one phenoxy group (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group In addition, at least one of them may be substituted)] in addition to 4-benzyl- (1-, 2- or 3 ) Piperidyl group, 3-benzyl- (1-, 2-, 4-, 5- or 6-) piperidyl group, 2-benzyl- (1-, 3-, 4-, 5- or 6-) piperidyl group, 2,4-dibenzyl- (1-, 3-, 5- or 6-) piperidyl group, 2,3,4-tribenzyl- (1-, 5- or 6-) piperidyl group, 4-phenoxy-3-benzyl A piperidyl group such as-(1-, 2-, 5- or 6-) piperidyl group [on the piperidine ring, a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group; 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups) and phenyl C1-6 alkyl groups. 1 to 3 groups may be substituted ] Can be exemplified.

Thiazolyl group (on the thiazole ring, a phenoxy C1-6 alkyl group [on the phenyl ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group And at least one of the groups selected may be substituted]; phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of alkoxy groups may be substituted]; a phenyl C1-6 alkyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group; At least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups is substituted. And may be]; group ^{_{- (W 1) oNR 31 R}} 32 [W 1 and o are as defined above .R ³¹ and R ³² are the same or different, a hydrogen atom, Cl to 6 alkyl group, a phenyl group ( On the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. Or a phenyl C1-6 alkyl group (on the phenyl ring, at least a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) A piperazinyl group [at least one phenyl group on the piperazine ring (halogen atom, halo on the phenyl ring)]; Or a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] A piperidyl group [on the piperidine ring is selected from the group consisting of a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; And at least one group selected from the group consisting of phenyl C1-6 alkyl groups may be substituted] and a phenoxy group [on the phenyl ring, Selected from the group consisting of halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups The group selected from the group consisting of at least one of the selected groups may be substituted] is, for example, (2-, 4- or 5-) Thiazolyl group, 2-[(4-fluoromethoxyphenoxy) methyl] -4-thiazolyl group, 4-[(4-fluoromethoxyphenoxy) methyl] -2-thiazolyl group, 2-[(4-fluoromethylphenoxy) methyl ] -4-thiazolyl group, 2-[(4-chlorophenoxy) methyl] -4-thiazolyl group, 2-[(3-methoxyphenoxy) methyl] -4-thiazolyl group, 2-[(2-methylphenoxy) Methyl] -5-thiazolyl group, 2-[(2,4-dimethoxyphenoxy) methyl] -5-thiazolyl group, 2-[(3,4-dimethylphenoxy) methyl] -4-thiazolyl group , 5-[(2,4,6-trimethoxyphenoxy) methyl-2-thiazolyl group, 2-[(3,4,5-trimethylphenoxy) methyl] -4-thiazolyl group, 2-[(2,4 , 6-trifluorophenoxy) methyl] -4-thiazolyl group, 4-([3,4-dichlorophenoxy] methyl) -2-thiazolyl group, 2- [4-bromophenoxy] methyl] -4-thiazolyl group, 2-[(4-iodophenoxy) methyl] -4-thiazolyl group, 4-[(4-fluorophenoxy) methyl] -2-thiazolyl group, 2,5-diphenoxymethyl-4-thiazolyl group, 4,5 -Diphenoxymethyl-2-thiazolyl group, 2- (4-fluorophenyl) -4-thiazolyl group, 4- (4-fluorophenyl) -2-thiazolyl group, 2- (4-chlorophenyl) 4-thiazolyl group, 4- (4-chlorophenyl) -2-thiazolyl group, 2- (4-trifluoromethylphenyl) -4-thiazolyl group, 2- (4-trifluoromethoxyphenyl) -4-thiazolyl group, 4- (4-trifluoromethylphenyl) -2-thiazolyl group, 4- (4-trifluoromethoxyphenyl) -2-thiazolyl group, 2- (3,4-dichlorophenyl) -4-thiazolyl group, 4- ( 3,4-dichlorophenyl) -2-thiazolyl group, 4- (2,4,6-trifluorophenyl) -2-thiazolyl group, 5- (4-bromophenyl) -2-thiazolyl group, 5- (4- Fluorophenyl) -4-thiazolyl group, 2- (4-iodophenyl) -5-thiazolyl group, 2- (4-methylphenyl) -4-thiazolyl group, 2- (4-methoyl group) Ciphenyl) -4-thiazolyl group, 2- (2,4-dimethylphenyl) -5-thiazolyl group, 4- (3,4-dimethoxyphenyl) -2-thiazolyl group, 4- (2,4,6-trimethyl) Phenyl) -5-thiazolyl group, 5- (3,4,5-trimethoxyphenyl) -4-thiazolyl group, 2,4-diphenyl-5-thiazolyl group, 4,5-diphenyl-2-thiazolyl group, 2 -Phenyl-5-phenoxymethyl-4-thiazolyl group, 2- (4-fluorobenzyl) -4-thiazolyl group, 2- (4-chlorobenzyl) -4-thiazolyl group, 2- (4-trifluoromethylbenzyl) ) -4-thiazolyl group, 2- (4-trifluoromethoxybenzyl) -4-thiazolyl group, 2- (3,4-dichlorobenzyl) -4-thiazolyl group, 4- (2,4,6) -Trifluorobenzyl) -2-thiazolyl group, 5- (4-bromobenzyl) -2-thiazolyl group, 5- (4-fluorobenzyl) -4-thiazolyl group, 2- (4-iodobenzyl) -5 Thiazolyl group, 2- (4-methylbenzyl) -4-thiazolyl group, 2- (4-methoxybenzyl) -4-thiazolyl group, 2- (2,4-dimethylbenzyl) -5-thiazolyl group, 4- ( 3,4-dimethoxybenzyl) -2-thiazolyl group, 4- (2,4,6-trimethylbenzyl) -5-thiazolyl group, 5- (3,4,5-trimethoxybenzyl) -4-thiazolyl group, 2,4-dibenzyl-5-thiazolyl group, 4,5-dibenzyl-2-thiazolyl group, 2-benzyl-5-phenoxymethyl-4-thiazolyl group, 4- (4-chlorobenzyl) amino- -Thiazolyl group, 4- (4-trifluoromethoxybenzyl) amino-2-thiazolyl group, 4- (4-trifluoromethylbenzyl) amino-2-thiazolyl group, 4- [N-methyl-N- (4- Chlorobenzyl) amino] -2-thiazolyl group, 4- [N-methyl-N- (4-trifluoromethoxybenzyl) amino] -2-thiazolyl group, 4- [N-methyl-N- (4-trifluoro) Methylbenzyl) amino] -2-thiazolyl group, 4- (4-chlorophenyl) amino-2-thiazolyl group, 4- (4-trifluoromethoxyphenyl) amino-2-thiazolyl group, 4- (4-trifluoromethyl) Phenyl) amino-2-thiazolyl group, 4- [N-methyl-N- (4-chlorophenyl) amino] -2-thiazolyl group, 4- [N-methyl-N- 4-trifluoromethoxyphenyl) amino] -2-thiazolyl group, 4- [N-methyl-N- (4-trifluoromethylphenyl) amino] -2-thiazolyl group, 4- (4-chlorobenzyl) aminomethyl 2-thiazolyl group, 4- (4-trifluoromethoxybenzyl) aminomethyl-2-thiazolyl group, 4- (4-trifluoromethylbenzyl) aminomethyl-2-thiazolyl group, 4- [N-methyl-N -(4-Chlorobenzyl) aminomethyl] -2-thiazolyl group, 4- [N-methyl-N- (4-trifluoromethoxybenzyl) aminomethyl] -2-thiazolyl group, 4- [N-methyl-N -(4-trifluoromethylbenzyl) aminomethyl] -2-thiazolyl group, 4- (4-chlorophenyl) aminomethyl-2-thiazolyl group, 4 -(4-trifluoromethoxyphenyl) aminomethyl-2-thiazolyl group, 4- (4-trifluoromethylphenyl) aminomethyl-2-thiazolyl group, 4- [N-methyl-N- (4-chlorophenyl) amino Methyl] -2-thiazolyl group, 4- [N-methyl-N- (4-trifluoromethoxyphenyl) aminomethyl] -2-thiazolyl group, 4- [N-methyl-N- (4-trifluoromethylphenyl) ) Aminomethyl] -2-thiazolyl group, 4- (4-bromobenzyl) amino-2-thiazolyl group, 4- (4-methoxybenzyl) amino-2-thiazolyl group, 4- (4-methylbenzyl) amino- 2-thiazolyl group, 4- [N-methyl-N- (3,4-dichlorobenzyl) amino] -2-thiazolyl group, 4- [N-methyl-N- (2,4 Dimethoxybenzyl) amino] -2-thiazolyl group, 4- [N-methyl-N- (3,4-dimethylbenzyl) amino] -2-thiazolyl group, 4- (4-bromophenyl) amino-2-thiazolyl group 4- (4-methoxyphenyl) amino-2-thiazolyl group, 4- (4-methylphenyl) amino-2-thiazolyl group, 4- [N-methyl-N- (3,4-dichlorophenyl) amino]- 2-thiazolyl group, 4- [N-methyl-N- (3,4-dimethoxyphenyl) amino] -2-thiazolyl group, 4- [N-methyl-N- (2,4-dimethylphenyl) amino]- 2-thiazolyl group, 4- (4-bromobenzyl) aminomethyl-2-thiazolyl group, 4- (4-methoxybenzyl) aminomethyl-2-thiazolyl group, 4- (4-methylbenzyl) Minomethyl-2-thiazolyl group, 4- [N-methyl-N- (3,4-dichlorobenzyl) aminomethyl] -2-thiazolyl group, 4- [N-methyl-N- (4-methoxybenzyl) aminomethyl ] -2-thiazolyl group, 4- [N-methyl-N- (3,4-dimethylbenzyl) aminomethyl] -2-thiazolyl group, 4- (4-bromophenyl) aminomethyl-2-thiazolyl group, 4 -(4-methoxyphenyl) aminomethyl-2-thiazolyl group, 4- (4-methylphenyl) aminomethyl-2-thiazolyl group, 4- [N-methyl-N- (3,4-dichlorophenyl) aminomethyl] 2-thiazolyl group, 4- [N-methyl-N- (2,4-dimethoxyphenyl) aminomethyl] -2-thiazolyl group, 4- [N-methyl-N- (3,4-dimethylphenyl) Enyl) aminomethyl] -2-thiazolyl group, 4- (4-fluorobenzyl) amino-2-thiazolyl group, 4- (2,4,6-trimethoxybenzyl) amino-2-thiazolyl group, 4- (3 , 4,5-trimethylbenzyl) amino-2-thiazolyl group, 4- [N-methyl-N- (4-iodobenzyl) amino] -2-thiazolyl group, 4- [N-methyl-N- (2, 4,6-trifluorobenzyl) amino] -2-thiazolyl group, 4- [N-methyl-N- (4-iodobenzyl) amino] -2-thiazolyl group, 4- (4-fluorophenyl) amino-2 -Thiazolyl group, 4- (2,4,6-trimethoxyphenyl) amino-2-thiazolyl group, 4- (3,4,5-trimethylphenyl) amino-2-thiazolyl group, 4- [N-methyl- N- (4 Iodophenyl) amino] -2-thiazolyl group, 4- [N-methyl-N- (2,4,6-trifluorophenyl) amino] -2-thiazolyl group, 4- (4-fluorobenzyl) aminomethyl- 2-thiazolyl group, 4- (3,4,6-trimethoxybenzyl) aminomethyl-2-thiazolyl group, 4- (2,4,6-trimethylbenzyl) aminomethyl-2-thiazolyl group, 4- [N -Methyl-N- (4-iodobenzyl) aminomethyl] -2-thiazolyl group, 4- [N-methyl-N- (2,4,6-trifluorobenzyl) aminomethyl] -2-thiazolyl group, 4 -(4-fluorophenyl) aminomethyl-2-thiazolyl group, 4- (2,4,6-trimethoxyphenyl) aminomethyl-2-thiazolyl group, 4- (3,4,5-trimethylphenyl) Nyl) aminomethyl-2-thiazolyl group, 4- [N-methyl-N- (4-iodophenyl) aminomethyl] -2-thiazolyl group, 4- [N-methyl-N- (2,4,6- Trifluorophenyl)



Minomethyl] -2-thiazolyl group, 4- [N-methyl-N- (4-trifluoromethylphenyl) aminomethyl] -2-thiazolyl group, 4- (4-trifluoromethoxyphenoxy) -2-thiazolyl group, 4- (4-trifluoromethylphenoxy) -2-thiazolyl group, 4- (4-chlorophenoxy) -2-thiazolyl group, 4- (3,4-dichlorophenoxy) -2-thiazolyl group, 4- (4 -Methoxyphenoxy) -2-thiazolyl group, 4- (4-methylphenoxy) -2-thiazolyl group, 4- (3,4-dimethoxyphenoxy) -2-thiazolyl group, 5- (2,4-dimethylphenoxy) -4-thiazolyl group, 4- (2,4,6-trimethoxyphenoxy) -5-thiazolyl group, 4- (3,4,5-trimethylphenoxy) -2-thia Ryl group, 4- (4-fluorophenoxy) -2-thiazolyl group, 2- (4-bromophenoxy) -5-thiazolyl group, 2- (4-iodophenoxy) -4-thiazolyl group, 5- (2, 4,6-trifluorophenoxy) -2-thiazolyl group, 4- [4- (4-trifluoromethylphenyl) -1-piperazinyl] -2-thiazolyl group, 4- [4- (4-trifluoromethoxyphenyl) ) -1-piperazinyl] -2-thiazolyl group, 4- [4- (4-chlorophenyl) -1-piperazinyl] -2-thiazolyl group, 4- [4- (4-trifluoromethylphenoxy) -1-piperidyl group ] -2-thiazolyl group, 4- [4- (4-trifluoromethoxyphenoxy) -1-piperidyl] -2-thiazolyl group, 4- [4- (4-chlorophenoxy)- -Piperidyl] -2-thiazolyl group, 5- [3,4-diphenyl-1-piperazinyl] -2-thiazolyl group, 2- [3,4,5-triphenyl-1-piperazinyl] -4-thiazolyl group, 5- [3,4,5-triphenoxy-1-piperidyl] -4-thiazolyl group, 4- [3,4-diphenoxy-1-piperidyl] -5-thiazolyl group, 4- [4- (4-tri Fluoromethoxyphenyl) -1-piperazinyl] -5-phenoxy-2-thiazolyl group, 4- [4- (4-trifluoromethoxyphenoxy) -1-piperidyl] -5-phenoxy-2-thiazolyl group, 4-phenyl 2-thiazolyl group, 2-phenyl-4-thiazolyl group, 2- [4-benzyl- (1-, 2- or 3-) piperidyl]-(4- or 5-) thiazolyl group A group comprising a phenoxy C1-6 alkyl group on a thiazole ring [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group 1 to 5, preferably 1 to 3 groups selected from above may be substituted]; phenyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted] Or 1 to 5, preferably 1 to 3 groups selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted]; a phenyl C1-6 alkyl group [on the phenyl ring, 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group Preferably it may be in 1-3 substituents]; group ^{_{- (W 1) oNR 31 R}} 32 [W 1 and o are as defined above. R ³¹ and R ³² are the same or different and each represents a hydrogen atom, a C1-6 alkyl group, a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted group. 1 to 5, preferably 1 to 3 groups selected from the group consisting of C1-6 alkoxy groups or a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen atom) 1 to 5, preferably 1 to 3 groups selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. . A piperazinyl group [on the piperazine ring, at least 1 to 3 phenyl groups (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6] 1 to 5, preferably 1 to 3 groups selected from the group consisting of alkoxy groups may be substituted]; piperidyl group [on the piperidine ring, a phenoxy group ( On the phenyl ring, there are 1 to 5, preferably 1 to 3, groups selected from the group consisting of halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups. 1 to 3 groups selected from the group consisting of a phenyl C1-6 alkyl group may be substituted] and a phenoxy group [on the phenyl ring, 1 to 5, preferably 1 to 3 groups selected from the group consisting of a gen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. A group selected from the group consisting of [good] may be substituted by 1 to 2 groups).

  An oxazolyl C1-6 alkyl group (on the oxazole ring, at least one phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 The group may be substituted with at least one group selected from the group consisting of alkoxy groups]. For example, [(2-, 4- or 5-) oxazolyl] methyl group , 1-[(2-, 4- or 5-) oxazolyl] ethyl group, 2-[(2-, 4- or 5-) oxazolyl] ethyl group, 3-[(2-, 4- or 5-) Oxazolyl] propyl group, 2-[(2-, 4- or 5-) oxazolyl] propyl group, 4-[(2-, 4- or 5-) oxazolyl] butyl group, 5-[(2-, 4- Or 5-) oxazolyl] pliers Group, 4-[(2-, 4- or 5-) oxazolyl] pentyl group, 6-[(2-, 4- or 5-) oxazolyl] hexyl group, 2-methyl-3-[(2-, 4 -Or 5-) oxazolyl] propyl group, 1,1-dimethyl-2-[(2-, 4- or 5-) oxazolyl] ethyl group, 4- (4-trifluoromethoxyphenyl)-(2- or 5 -) Oxazolylmethyl group, 4- (4-chlorophenyl)-(2- or 5-) oxazolylmethyl group, 4- (4-trifluoromethylphenyl)-(2- or 5-) oxazolyl A methyl group, 4- (4-methylphenyl)-(2- or 5-) oxazolylmethyl group, 4- (4-methoxyphenyl)-(2- or 5-) oxazolylmethyl group, 4- ( 2,4-dichlorophenyl)-(2- or 5-) oxazo Rumethyl group, 4- (2,4,6-trifluorophenyl)-(2- or 5-) oxazolylmethyl group, 2- (3,4-dimethylphenyl)-(4- or 5-) oxazoly Rumethyl group, 5- (3,4,6-trimethylphenyl)-(2- or 4-) oxazolylmethyl group, 2- (3,4-dimethoxyphenyl)-(4- or 5-) oxazoly Rumethyl group, 4- (2,4,6-trimethoxyphenyl)-(2- or 5-) oxazolylmethyl group, 4- (3-chloro-4-trifluoromethoxyphenyl)-(2- or 5-) Oxazolylmethyl group, 2,4-diphenyl-5-oxazolylmethyl group, 4,5-diphenyl-2-oxazolylmethyl group, 2,5-diphenyl-5-oxazolylmethyl group Straight chain having 1 to 6 carbon atoms or Oxazolyl C1-6 alkyl group which is a branched alkyl group [on the oxazole ring, 1-2 phenyl groups (on the phenyl ring, halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen 1 to 5, preferably 1 to 3 groups selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted]. .

  An isoxazolyl group (on the isoxazoline ring, from at least one phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group The group selected from the group consisting of at least one group optionally substituted] may be substituted, for example, (3-, 4- or 5-) isoxazolyl group, 3-phenyl- ( 4- or 5-) isoxazolyl group, 4-phenyl- (3- or 5-) isoxazolyl group, 5-phenyl- (3- or 4-) isoxazolyl group, 3,4-diphenyl-5-isoxazolyl group, 3, 5-diphenyl-4-isoxazolyl group, 4,5-diphenyl-3-isoxazolyl group, 3- (4-trifluorophenyl)-(4- or -) Isoxazolyl group, 4- (4-chlorophenyl)-(3- or 5-) isoxazolyl group, 3- (4-trifluoromethylphenyl)-(4- or 5-) isoxazolyl group, 4- (4-methyl) Phenyl)-(3- or 5-) isoxazolyl group, 3- (4-methoxyphenyl)-(4- or 5-) isoxazolyl group, 4- (2,4-dichlorophenyl)-(3- or 5-) isoxazolyl A group, 3- (2,4,6-trifluorophenyl)-(4- or 5-) isoxazolyl group, 3- (3,4-diphenylmethyl)-(4- or 5-) isoxazolyl group, 5- ( 3,4,6-trimethylphenyl)-(3- or 4-) isoxazolyl group, 3- (3,4-dimethoxyphenyl)-(4- or 5-) isoxazolyl group, 4- 2,4,6-trimethoxyphenyl)-(3- or 5-) isoxazolyl group, isoxazolyl group such as 3- (3-chloro-4-trifluoromethoxyphenyl)-(4- or 5-) isoxazolyl group [ 1 to 2 phenyl groups on the isoxazoline ring (on the phenyl ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) 1 to 5, more preferably 1 to 3 groups, which may be substituted, may be substituted].

  Examples of the benzoxazolyl group (at least one halogen atom may be substituted on the benzoxazole ring) include, for example, (2-, 4-, 5-, 6- or 7-) benzooxa A zolyl group, a 5-chloro- (2-, 4-, 6- or 7-) benzoxazolyl group, a 6-chloro- (2-, 4-, 5- or 7-) benzoxazolyl group, 5-fluoro- (2-, 4-, 6- or 7-) benzoxazolyl group, 6-bromo- (2-, 4-, 5- or 7-) benzoxazolyl group, 5-iodo- (2-, 4-, 6- or 7-) benzoxazolyl group, 5,6-dichloro- (2-, 4- or 7-) benzoxazolyl group, 4,5,6-trifluoro- (2- or 7-) benzoxazolyl group, 5-fluoro-6-chloro- (2-, 4- or 7-) benzo (On the benzoxazole ring may be 1 to 3 halogen atoms are substituted) benzoxazolyl group such Kisazoriru group can be exemplified.

  Benzimidazolyl group [on the benzimidazole ring, a halogen atom and a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 The group selected from the group consisting of at least one group selected from the group consisting of alkoxy groups may be substituted.] For example, (2-, 4-, 5-, 6- or 7-) benzimidazolyl group, 1- (4-trifluoromethoxybenzyl) -5,6-dichloro- (2-, 4- or 7-) benzimidazolyl group, 5-chloro- ( 1-, 2-, 4-, 6- or 7-) benzimidazolyl group, 6-chloro- (1-, 2-, 4-, 5- or 7-) benzimidazolyl group, 5-fluoro- ( -, 2-, 4-, 6- or 7-) benzimidazolyl group, 6-bromo- (1-, 2-, 4-, 5- or 7-) benzimidazolyl group, 5-iodo- (1-, 2- , 4-, 6- or 7-) benzoimidazolyl group, 5,6-dichloro- (1-, 2-, 4- or 7-) benzimidazolyl group, 4,5,6-trifluoro- (1-, 2- Or 7-) benzimidazolyl group, 5-fluoro-6-chloro- (1-, 2-, 4- or 7-) benzimidazolyl group, 1-benzyl- (2-, 4-, 5-, 6- or 7- ) Benzimidazolyl group, 1- (4-trifluoromethylbenzyl)-(2-, 4-, 5-, 6- or 7-) benzimidazolyl group, 1- (4-chlorobenzyl)-(2-, 4-, 5-, 6- or 7-) benzimidazolyl group, 1- (3-methyl Rubenzyl)-(2-, 4-, 5-, 6- or 7-) benzimidazolyl group, 1- (2-methoxybenzyl)-(2-, 4-, 5-, 6- or 7-) benzimidazolyl group, 1- (3,4-dimethylbenzyl)-(2-, 4-, 5-, 6- or 7-) benzimidazolyl group, 1- (2,4,6-trimethylbenzyl)-(2-, 4-, 5-, 6- or 7-) benzimidazolyl group, 1- (3,4-dimethoxybenzyl)-(2-, 4-, 5-, 6- or 7-) benzimidazolyl group, 1- (2,4,5 -Trimethoxybenzyl)-(2-, 4-, 5-, 6- or 7-) benzimidazolyl group, 1- (3,4-dichlorobenzyl)-(2-, 4-, 5-, 6- or 7 -) Benzimidazolyl group, 1- (2,4,6-trifluorobenzyl)-( 2-, 4-, 5-, 6- or 7-) benzimidazolyl group, 1- (3-chloro-4-trifluoromethylbenzyl)-(2-, 4-, 5-, 6- or 7-) benzimidazolyl Benzoimidazolyl groups such as 1,5-dibenzyl- (2-, 4-, 6- or 7-) benzoimidazolyl groups, 1,5,6-tribenzyl- (2-, 4- or 7-) benzoimidazolyl groups [On the benzimidazole ring, a halogen atom and a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group 1 to 5, preferably 1 to 3 groups selected from the group consisting of 1 to 3 groups may be substituted].

  An imidazolyl group (consisting of at least one phenyl group on the imidazole ring [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; As at least one kind selected from the group may be substituted], for example, 2-phenyl- (4- or 5-) imidazolyl group, 4-phenyl- (2- or 5-) imidazolyl group, 2,4-diphenyl-5-imidazolyl group, 2,4-diphenyl-5-imidazolyl group, 4,5-diphenyl-2-imidazolyl group, 2- (4-trifluoro Methoxyphenyl)-(4- or 5-) imidazolyl group, 2- (4-trifluorophenyl)-(4- or 5-) imidazolyl group, 4- (4-chlorophene) L)-(2- or 5-) imidazolyl group, 4- (4-trifluoromethylphenyl)-(2- or 5-) imidazolyl group, 4- (4-methylphenyl) -2-imidazolyl group, 2- (4-methoxyphenyl)-(4- or 5-) imidazolyl group, 4- (2,4-dichlorophenyl)-(2- or 5-) imidazolyl group, 2- (2,4,6-trifluorophenyl) -(4- or 5-) imidazolyl group, 2- (3,4-diphenylmethyl)-(4- or 5-) imidazolyl group, 5- (3,4,6-trimethylphenyl)-(2- or 4 -) Imidazolyl group, 2- (3,4-dimethoxyphenyl)-(4- or 5-) imidazolyl group, 4- (2,4,6-trimethoxyphenyl)-(2- or 5-) imidazolyl group, 5- (3-Chloro-4-to An imidazolyl group such as fluoromethoxyphenyl)-(2- or 4-) imidazolyl group (on the imidazole ring, 1 to 2 phenyl groups [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1- 1 to 5 groups, preferably 1 to 3 groups selected from the group consisting of 6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups, may be substituted. ).

  Phenylsulfinyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. May be, for example, an unsubstituted phenylsulfinyl group and a halogen atom as defined above, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. A phenylsulfinyl group having 1 to 5, preferably 1 to 3 substituents selected from the group, for example, phenylsulfinyl group, 2-fluorophenylsulfinyl group, 3-fluorophenylsulfinyl group, 4-fluoro Phenylsulfinyl group, 2-chlorophenylsulfinyl group, 3-c Rophenylsulfinyl group, 4-chlorophenylsulfinyl group, 2-bromophenylsulfinyl group, 3-bromophenylsulfinyl group, 4-bromophenylsulfinyl group, 2-iodophenylsulfinyl group, 3-iodophenylsulfinyl group, 4-iodophenyl Sulfinyl group, 2,3-difluorophenylsulfinyl group, 3,4-difluorophenylsulfinyl group, 3,5-difluorophenylsulfinyl group, 2,4-difluorophenylsulfinyl group, 2,6-difluorophenylsulfinyl group, 2, 3-dichlorophenylsulfinyl group, 3,4-dichlorophenylsulfinyl group, 3,5-dichlorophenylsulfinyl group, 2,4-dichlorophenylsulfinyl group, 2,6-dichlorophenylsulfuric group Nyl group, 3,4,5-trifluorophenylsulfinyl group, 3,4,5-trichlorophenylsulfinyl group, 2,4,6-trifluorophenylsulfinyl group, 2,4,6-trichlorophenylsulfinyl group, 2 -Fluoro-4-bromophenylsulfinyl group, 4-chloro-3-fluorophenylsulfinyl group, 2,3,4-trichlorophenylsulfinyl group, 2,3,4,5,6-pentafluorophenylsulfinyl group, 2, 4,6-trimethylphenylsulfinyl group, 4-n-butylphenylsulfinyl group, 2,4-dimethylphenylsulfinyl group, 2,3-dimethylphenylsulfinyl group, 2,6-dimethylphenylsulfinyl group, 3,5-dimethyl Phenylsulfinyl group, 2,5-dimethylphenyls Rufinyl group, 3,5-ditrifluoromethylphenylsulfinyl group, 4-n-butoxyphenylsulfinyl group, 2,4-dimethoxyphenylsulfinyl group, 2,3-dimethoxyphenylsulfinyl group, 2,6-dimethoxyphenylsulfinyl group, 3,5-dimethoxyphenylsulfinyl group, 2,5-dimethoxyphenylsulfinyl group, 2,4,6-trimethoxyphenylsulfinyl group, 3,5-ditrifluoromethoxyphenylsulfinyl group, 3-chloro-4-methoxyphenylsulfinyl group Group, 2-chloro-4-trifluoromethoxyphenylsulfinyl group, 3-methyl-4-fluorophenylsulfinyl group, 4-bromo-3-trifluoromethylphenylsulfinyl group, 2-methylphenylsulfinyl group, -Methylphenylsulfinyl group, 4-methylphenylsulfinyl group, 2-methyl-3-chlorophenylsulfinyl group, 3-methyl-4-chlorophenylsulfinyl group, 2-chloro-4-methylphenylsulfinyl group, 2-methyl-3- Fluorophenylsulfinyl group, 2-trifluoromethylphenylsulfinyl group, 3-trifluoromethylphenylsulfinyl group, 4-trifluoromethylphenylsulfinyl group, 2-pentafluoroethylphenylsulfinyl group, 3-pentafluoroethylphenylsulfinyl group, 4-pentafluoroethylphenylsulfinyl group, 2-isopropylphenylsulfinyl group, 3-isopropylphenylsulfinyl group, 4-isopropylphenylsulfinyl group, 2-ter -Butylphenylsulfinyl group, 3-tert-butylphenylsulfinyl group, 4-tert-butylphenylsulfinyl group, 2-sec-butylphenylsulfinyl group, 3-sec-butylphenylsulfinyl group, 4-sec-butylphenylsulfinyl group 2-n-heptafluoropropylphenylsulfinyl group, 3-n-heptafluoropropylphenylsulfinyl group, 4-n-heptafluoropropylphenylsulfinyl group, 4-n-pentylphenylsulfinyl group, 4-n-hexylphenylsulfinyl group Group, 2-methoxyphenylsulfinyl group, 3-methoxyphenylsulfinyl group, 4-methoxyphenylsulfinyl group, 3-chloro-2-methoxyphenylsulfinyl group, 2-fluoro-3-meth Xiphenylsulfinyl group, 2-fluoro-4-methoxyphenylsulfinyl group, 2,3,4-trifluorophenylsulfinyl group, 2-trifluoromethoxyphenylsulfinyl group, 3-trifluoromethoxyphenylsulfinyl group, 4-trifluoro Methoxyphenylsulfinyl group, 3-fluoro-2-trifluoromethoxyphenylsulfinyl group, 2-fluoro-3-trifluoromethoxyphenylsulfinyl group, 3-fluoro-4-trifluoromethoxyphenylsulfinyl group, 3-chloro-2- Trifluoromethoxyphenylsulfinyl group, 2-chloro-3-trifluoromethoxyphenylsulfinyl group, 3-chloro-4-trifluoromethoxyphenylsulfinyl group, 2-pentafluoroethoxyphene Rusulfinyl group, 3-pentafluoroethoxyphenylsulfinyl group, 4-pentafluoroethoxyphenylsulfinyl group, 3-chloro-2-pentafluoroethoxyphenylsulfinyl group, 2-chloro-3-pentafluoroethoxyphenylsulfinyl group, 3- Chloro-4-pentafluoroethoxyphenylsulfinyl group, 2-isopropoxyphenylsulfinyl group, 3-isopropoxyphenylsulfinyl group, 4-isopropoxyphenylsulfinyl group, 2-tert-butoxyphenylsulfinyl group, 3-tert-butoxyphenyl Sulfinyl group, 4-tert-butoxyphenylsulfinyl group, 2-sec-butoxyphenylsulfinyl group, 3-sec-butoxyphenylsulfinyl group, 4-se -Butoxyphenylsulfinyl group, 2-n-heptafluoropropoxyphenylsulfinyl group, 3-n-heptafluoropropoxyphenylsulfinyl group, 4-n-heptafluoropropoxyphenylsulfinyl group, 4-n-pentoxyphenylsulfinyl group, 4 -N-hexyloxyphenylsulfinyl group and the like can be mentioned.

  Examples of the imidazolyl group (on the imidazole ring, at least one group selected from the group consisting of a halogen atom and a nitro group may be substituted) include (1-, 2-, 4- or 5- ) Imidazolyl group, 2-chloro-4-nitro- (1- or 5-) imidazolyl group, 2-bromo- (1-, 4- or 5-) imidazolyl group, 4-fluoro- (1-, 2- or 5-) imidazolyl group, 2,5-dichloro- (1- or 4-) imidazolyl group, 2,4,5-trichloro-1-imidazolyl group, 2-nitro- (1-, 4- or 5-) imidazolyl Group, 4-nitro- (1-, 2- or 5-) imidazolyl group, 2,5-dinitro- (1- or 4-) imidazolyl group, 2,4,5-trinitro-1-imidazolyl group, etc. Group (on the imidazole ring Groups selected from halogen atoms and nitro group consisting group can be exemplified a may) also be 1-3 substituents.

  A phenyl C1-6 alkyl group (on the phenyl ring, a group selected from the group consisting of a benzofuryl group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; At least one of them may be substituted) on the phenyl C1-6 alkyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted) 4-[(2-, 3-, 4-, 5-, 6- or 7) may be substituted with at least one group selected from the group consisting of C1-6 alkoxy groups. -) Benzofuryl] benzyl group, 2-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] benzyl group, 3-[(2-, 3-, 4-, 5-, 6- or 7- Benzofuryl] benzyl group, 2,4-di [(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] benzyl group, 2,4,6-tri [(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] benzyl group, 2-trifluoromethyl-4- (2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] benzyl group, 3 -Trifluoromethoxy-4- (2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] benzyl group, 4-chloro-3- (2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] A phenyl C1-6 alkyl group in which the alkyl portion such as a benzyl group is a linear or branched alkyl group having 1 to 6 carbon atoms (on the phenyl ring, a benzofuryl group, a halogen atom) Halogen substituted or unsubstituted C1-6 alkyl groups and halogen substituted Can be exemplified the one to five groups selected from the group consisting of C1~6 alkoxy group unsubstituted, preferably it may be in 1-3 substituents).

  Furyl C1-6 alkyl group [on the furan ring, at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 The group may be substituted with at least one group selected from the group consisting of alkoxy groups]. For example, (2- or 3-) furylmethyl group, 1-[( 2- or 3-) furyl] ethyl group, 2-[(2- or 3-) furyl] ethyl group, 3-[(2- or 3-) furyl] propyl group, 2-[(2- or 3- ) Furyl] propyl group, 4-[(2- or 3-) furyl] butyl group, 5-[(2- or 3-) furyl] pentyl group, 4-[(2- or 3-) furyl] pentyl group , 6-[(2- or 3-) furyl] hexyl group, 1,1-dimethyl-2- [ 2- or 3-) furyl] ethyl group, 2-methyl-3-[(2- or 3-) furyl] propyl group, 2- (4-chlorophenyl)-(3-, 4- or 5-) furylmethyl Group, 2- (2-chloro-5-trifluoromethylphenyl)-(3-, 4- or 5-) furylmethyl group, 2- (4-trifluoromethoxyphenyl)-(3-, 4- or 5 -) Furylmethyl group, 2- (2,4-dichlorophenyl)-(3-, 4- or 5-) furylmethyl group, 2- (2,4,6-trifluorophenyl)-(3-, 4- Or 5-) furylmethyl group, 2- (4-methylphenyl)-(3-, 4- or 5-) furylmethyl group, 2- (4-methoxyphenyl)-(3-, 4- or 5-) Furylmethyl group, 2- (2,4-dimethylphenyl)-(3-, 4- or 5-) furyl Methyl group, 2- (3,4-dimethoxyphenyl)-(3-, 4- or 5-) furylmethyl group, 2- (2,4,6-trimethylphenyl)-(3-, 4- or 5- ) Furylmethyl group, 2- (3,4,5-trimethoxyphenyl)-(3-, 4- or 5-) furylmethyl group, 2,4-diphenyl- (3- or 5-) furylmethyl group, A furyl C1-6 alkyl group in which the alkyl moiety such as 2,4,5-triphenyl-3-furylmethyl group is a linear or branched alkyl group having 1 to 6 carbon atoms [on the furan ring, 1 ~ 3 phenyl groups (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is 1 to 5 may be substituted, preferably 1 to 3 ) Can be exemplified a] may be substituted.

  Pyridyl C1-6 alkyl group [furyl group and phenyl group on pyridine ring (halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy on phenyl ring) The group selected from the group consisting of at least one group selected from the group consisting of groups may be substituted]], for example, the pyridyl C1 ~ In addition to 6 alkyl groups, 3- (2- or 3-) furyl- (2-, 4-, 5- or 6-) pyridylmethyl groups, 2- (4-trifluoromethoxyphenyl)-(3-, 4-, 5- or 6-pyridylmethyl group, 2- (4-trifluoromethylphenyl)-(3-, 4-, 5- or 6-) pyridylmethyl group, 2- (4-methoxyphenyl)- (3- 4-, 5- or 6-) pyridylmethyl group, 2- (4-methylphenyl)-(3-, 4-, 5- or 6-) pyridylmethyl group, 2- (3-chloro-4-fluorophenyl) )-(3-, 4-, 5- or 6-) pyridylmethyl group, 2- (2,4-dimethoxyphenyl)-(3-, 4-, 5- or 6-) pyridylmethyl group, 2- ( 3,4,5-trimethoxyphenyl)-(3-, 4-, 5- or 6-) pyridylmethyl group, 2- (2,4-dimethylphenyl)-(3-, 4-, 5- or 6 -) Pyridylmethyl group, 2- (2,4,6-trimethylphenyl)-(3-, 4-, 5- or 6-) pyridylmethyl group, 2- (2,4,6-trichlorophenyl)-( 3-, 4-, 5- or 6-) pyridylmethyl group, 2- (3-chloro-4-trifluoromethoxy) Enyl)-(3-, 4-, 5- or 6-) pyridylmethyl group, 2,4-di (2- or 3-) furyl- (5- or 6-) pyridylmethyl group, 2,4,6 An alkyl moiety such as -triphenyl- (3- or 5-) pyridylmethyl group, 2-furyl-5-phenyl- (3-, 4- or 6-) pyridylmethyl group is a straight chain having 1 to 6 carbon atoms or Pyridyl C1-6 alkyl group which is a branched alkyl group [furyl group and phenyl group on pyridine ring (benzofuryl group, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group on phenyl ring) And a group selected from the group consisting of 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups. 3 may be substituted] The

  As the benzothienyl C1-6 alkyl group (at least one halogen atom may be substituted on the benzothiophene ring), for example, 2-benzothienylmethyl group, 1- (2-benzothienyl) ethyl Group, 2- (4-benzothienyl) ethyl group, 3- (5-benzothienyl) propyl group, 4- (6-benzothienyl) butyl group, 5- (7-benzothienyl) pentyl group, 6- (2 -Benzothienyl) hexyl group, 4-fluoro-2-benzothienylmethyl group, 5-fluoro-2-benzothienylmethyl group, 6-fluoro-2-benzothienylmethyl group, 7-fluoro-2-benzothienylmethyl group 4-chloro-2-benzothienylmethyl group, 5-chloro-2-benzothienylmethyl group, 6-chloro-2-benzothienylmethyl group, -Chloro-2-benzothienylmethyl group, 4-bromo-2-benzothienylmethyl group, 5-bromo-2-benzothienylmethyl group, 6-bromo-2-benzothienylmethyl group, 7-bromo-2-benzo Thienylmethyl group, 4-iodo-2-benzothienylmethyl group, 5-iodo-2-benzothienylmethyl group, 6-iodo-2-benzothienylmethyl group, 7-iodo-2-benzothienylmethyl group, 4- Fluoro-3-benzothienylmethyl group, 5-fluoro-3-benzothienylmethyl group, 6-fluoro-3-benzothienylmethyl group, 7-fluoro-3-benzothienylmethyl group, 4-chloro-3-benzothienyl group Methyl group, 5-chloro-3-benzothienylmethyl group, 6-chloro-3-benzothienylmethyl group, 7-chloro-3-phenyl Zothienylmethyl group, 4-bromo-3-benzothienylmethyl group, 5-bromo-3-benzothienylmethyl group, 6-bromo-3-benzothienylmethyl group, 7-bromo-3-benzothienylmethyl group, 4 -Iodo-3-benzothienylmethyl group, 5-iodo-3-benzothienylmethyl group, 6-iodo-3-benzothienylmethyl group, 7-iodo-3-benzothienylmethyl group, 2- (4-fluoro- 2-benzothienyl) ethyl group, 2- (5-fluoro-2-benzothienyl) ethyl group, 2- (6-fluoro-2-benzothienyl) ethyl group, 2- (7-fluoro-2-benzothienyl) Ethyl, 2- (4-chloro-2-benzothienyl) ethyl, 2- (5-chloro-2-benzothienyl) ethyl, 2- (6-chloro-2-benzothi) Enyl) ethyl group, 2- (7-chloro-2-benzothienyl) ethyl group, 2- (4-fluoro-3-benzothienyl) methyl group, 2- (5-fluoro-3-benzothienyl) methyl group, 2- (6-fluoro-3-benzothienyl) ethyl group, 2- (7-fluoro-3-benzothienyl) ethyl group, 2- (4-chloro-3-benzothienyl) ethyl group, 2- (5- Chloro-3-benzothienyl) ethyl group, 2- (6-chloro-3-benzothienyl) ethyl group, 2- (7-chloro-3-benzothienyl) ethyl group, 2- (4-fluoro-2-benzo) Thienyl) ethyl group, 6- (5-fluoro-2-benzothienyl) hexyl group, 6- (6-fluoro-2-benzothienyl) hexyl group, 6- (7-fluoro-2-benzothienyl) hexyl group, 6 (4-chloro-2-benzothienyl) hexyl group, 6- (5-chloro-2-benzothienyl) hexyl group, 6- (6-chloro-2-benzothienyl) hexyl group, 6- (7-chloro- 2-benzothienyl) hexyl group, 6- (4-fluoro-3-benzothienyl) methyl group, 6- (5-fluoro-3-benzothienyl) hexyl group, 6- (6-fluoro-3-benzothienyl) Hexyl group, 6- (7-fluoro-3-benzothienyl) hexyl group, 6- (4-chloro-3-benzothienyl) hexyl group, 6- (5-chloro-3-benzothienyl) hexyl group, 6- (6-chloro-3-benzothienyl) hexyl group, 6- (7-chloro-3-benzothienyl) hexyl group, (2,4-dibromo-3-benzothienyl) methyl group, (4,5,6) Trichloro-3-benzothienyl) can be halogen atoms on a benzofuran ring, such as a methyl group include 1 to 3 substituents and may optionally benzothienyl substituted C1~6 alkyl group.

  A benzofuryl C2-6 alkenyl group (on the benzofuran ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) The seed may be substituted) means 1 to 3 groups selected from unsubstituted or halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups. It is a group composed of one substituted benzofuryl and a linear or branched alkenyl group having 2 to 6 carbon atoms and 1 to 3 double bonds, and the benzofuryl C2-6 alkenyl group is a trans isomer And both cis isomers. Examples of such benzofuryl C2-6 alkenyl group include 2-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] vinyl group, 3-[(2-, 3- , 4-, 5-, 6- or 7-) benzofuryl] -2-propenyl group, 3-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] -2-methyl- 2-propenyl group, 4-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] -2-butenyl group, 4-[(2-, 3-, 4-, 5- , 6- or 7-) benzofuryl] -3-butenyl group, 4-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] -1,3-butadienyl group, 5- [ (2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] -1,3,5-hexatrienyl group, 6-[(2-, 3-, 4-, 5) , 6- or 7-) benzofuryl] -1,3-hexadienyl group, 3- [6-trifluoromethyl- (2-, 3-, 4-, 5- or 7-) benzofuryl] -2-propenyl group, 3- [5-trifluoromethoxy- (2-, 3-, 4-, 5- or 7-) benzofuryl] -2-propenyl group, 3- [7-chloro- (2-, 3-, 4-, 5- or 7-) benzofuryl] -2-propenyl group, 3- [2,6-dimethyl- (3-, 4-, 5- or 7-) benzofuryl] -2-propenyl group, 3- [3,6 -Dimethoxy- (2-, 3-, 4-, 5- or 7-) benzofuryl] -2-propenyl group, 3- [4,5,6-trimethyl- (2-, 3- or 7-) benzofuryl] A 2-propenyl group, 3- [3,5,6-trimethoxy- (2-, 4- or 7-) A zofuryl] -2-propenyl group, a 3- [3-chloro-6-trifluoromethyl- (2-, 3-, 4-, 5- or 7-) benzofuryl] -2-propenyl group, and the like. .

  A thiazolyl group [consisting of at least one phenyl group on the thiazole ring (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) The group may be substituted with at least one group selected from the group] may be substituted, for example, (2-, 4- or 5-) thiazolyl group, 4-phenyl- (2 -Or 5-) thiazolyl group, 2-phenyl- (4- or 5-) thiazolyl group, 5-phenyl- (2- or 4-) thiazolyl group, 2,5-diphenyl-4-thiazolyl group, 2,4 -Diphenyl-5-thiazolyl group, 2- (4-trifluoromethylphenyl)-(4- or 5-) thiazolyl group, 2- (4-trifluoromethoxyphenyl)-(4- or 5-) Azolyl group, 2- (4-chlorophenyl)-(4- or 5-) thiazolyl group, 2- (3-chloro-4-trifluoromethylphenyl)-(4- or 5-) thiazolyl group, 2- (4 -Methylphenyl)-(4- or 5-) thiazolyl group, 2- (2,4-dimethylphenyl)-(4- or 5-) thiazolyl group, 2- (3,4,6-trimethylphenyl)-( 4- or 5-) thiazolyl group, 2- (4-methoxyphenyl)-(4- or 5-) thiazolyl group, 2- (2,4-dimethoxyphenyl)-(4- or 5-) thiazolyl group, 2 -(3,4,6-trimethoxyphenyl)-(4- or 5-) thiazolyl group, 2- (2,4-dichlorophenyl)-(4- or 5-) thiazolyl group, 2- (3,4, 6-trifluorophenyl)-(4- or 5-) A thiazolyl group such as an azolyl group [on the thiazole ring, 1-2 phenyl groups (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1- 1 to 5, preferably 1 to 3 groups selected from the group consisting of 6 alkoxy groups may be substituted].

  Isoindolinyloxy group [on the isoindoline ring, a C1-6 alkoxycarbonyl group, a phenyl C1-6 alkyl group (on the phenyl ring, a benzofuryl group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group And at least one group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted, a phenyl C2-6 alkenyl group (on the phenyl ring, a halogen atom, a halogen At least one group selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), a furyl C1-6 alkyl group [ On the furan ring, at least one phenyl group (on the phenyl ring, a halogen atom, halogen-substituted or At least one group selected from the group consisting of a substituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted],] pyridyl C1 -6 alkyl group [furyl group and phenyl group on pyridine ring (benzofuryl group, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 on phenyl ring) At least one group selected from the group consisting of a group selected from the group consisting of alkoxy groups may be substituted)], a benzofuryl C1-6 alkyl group ( On the benzofuran ring are halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alcohols. And at least one group selected from the group consisting of cis group may be substituted), a benzothienyl C1-6 alkyl group (on the benzothiophene ring, at least one halogen atom may be substituted) Benzofuryl C2-6 alkenyl group (on the benzofuran ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one of them may be substituted), a thiazolyl group [on the thiazole ring, at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen At least one group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted). Optionally substituted] and a phenoxy C1-6 alkyl group (on the phenyl ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group). The group selected from the group consisting of a group selected from the group consisting of at least one group selected from more may be substituted]. For example, (1-, 2-3, -Or 4-) isoindolinyloxy group, 1-tert-butoxycarbonyl- (2-, 3- or 4-) isoindolinyloxy group, 1- [2- (4-chlorophenyl)-(3-, 4 -Or 5-) furylmethyl]-(2-, 3- or 4-) isoindolinyloxy group, 1- [2- (2-chloro-5-trifluoromethylphenyl)-(3-, 4- or 5-) Frills Til]-(2-, 3- or 4-) isoindolinyloxy group, 1- (3-trifluoromethyl-4-chlorobenzyl)-(2-, 3- or 4-) isoindolinyloxy group, 1- {4-[(2-, 3-, 4-, 5-, 6- or 7-) benzofuryl] benzyl}-(2-, 3- or 4-) isoindolinyloxy group, 1- {3 -[(2- or 3-) furyl]-(2-, 4-, 5- or 6-) pyridylmethyl}-(2-, 3- or 4-) isoindolinyloxy group, 1- [2- (4-trifluoromethoxyphenyl)-(3-, 4-, 5- or 6-) pyridylmethyl]-(2-, 3- or 4-) isoindolinyloxy group, 1- [2- (3- Chloro-4-fluorophenyl)-(3-, 4-, 5- or 6-) pyridylmethyl]-(2-, 3- or 4-) isoindolinyloxy group, 1- [6-trifluoromethyl- (2-, 3-, 4-, 5- or 7-) benzofurylmethyl]-(2-, 3- or 4-) iso Indolinyloxy group, 1- [5-chloro- (2-, 3-, 4-, 6- or 7-) benzothienylmethyl]-(2-, 3- or 4-) isoindolinyloxy group, 1 -[6-Chloro- (2-, 3-, 4-, 5-, or 7-) benzofurylmethyl]-(2-, 3- or 4-) isoindolinyloxy group, 1- [5-tri Fluoromethoxy- (2-, 3-, 4-, 6- or 7-) benzofurylmethyl]-(2-, 3- or 4-) isoindolinyloxy group, 1- {3- [6-trifluoro Methyl- (2-, 3-, 4-, 5- or 7-) benzofuryl] -2-propenyl}-(2-, 3- Is 4-) isoindolinyloxy group, 1- [5-chloro- (2-, 3-, 4-, 6- or 7-) benzofurylmethyl]-(2-, 3- or 4-) isoindolini Nyloxy group, 1- [2- (4-trifluoromethylphenyl)-(4- or 5-) thiazolylmethyl]-(2-, 3- or 4-) isoindolinyloxy group, 1- [2- ( 4-trifluoromethoxyphenoxy) ethyl]-(2-, 3- or 4-) isoindolinyloxy group, 1,3-diethoxycarbonyl- (2- or 4-) isoindolinyloxy group, 2- Phenoxymethyl-4-[(2-, 3-, 4-, 5-, 6- or 7-) benzofurylmethyl]-(1-, 3-, 5-, 6- or 7-) isoindolinyloxy The group 2-[(2- or 3-) furylmethyl] -4,5-dimethyl. An isoindolinyloxy group such as xoxycarbonyl- (1-, 3-, 6- or 7-) isoindolinyloxy group [on the isoindoline ring, a linear or branched chain having 1 to 6 carbon atoms; A C1-6 alkoxycarbonyl group, a phenyl C1-6 alkyl group in which the alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms (on the phenyl ring, a benzofuryl group, a halogen atom, 1 to 5, preferably 1 to 3 groups selected from the group consisting of substituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups), A phenyl C2-6 alkenyl group (phenyl) which is a linear or branched alkenyl group having 2 to 6 carbon atoms and having 1 to 3 double bonds, and includes both trans and cis isomers. On the ring, there are 1 to 5, preferably 1 to 3, groups selected from the group consisting of halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups. Optionally substituted), a furyl C1-6 alkyl group in which the alkyl part is a linear or branched alkyl group having 1 to 6 carbon atoms [on the furan ring, 1 to 3 phenyl groups ( 1 to 5 groups selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring, preferably 1 to 3 may be substituted)], a pyridyl C1-6 alkyl group in which the alkyl portion is a linear or branched alkyl group having 1 to 6 carbon atoms [on the pyridine ring , Furyl group A phenyl group (on the phenyl ring, a group selected from the group consisting of a benzofuryl group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group; A group selected from the group consisting of 1 to 3, preferably 1 to 3 groups may be substituted], a linear or branched alkyl group having 1 to 6 carbon atoms A benzofuryl C1-6 alkyl group which is a chain alkyl group (on the benzofuran ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) Benzothienyl C1-6 alkyl group (wherein the alkyl group may be a linear or branched alkyl group having 1 to 6 carbon atoms) 1 to 3 halogen atoms may be substituted on the nzothiophene ring), a linear or branched alkenyl group having 2 to 6 carbon atoms and 1 to 3 double bonds in the alkenyl moiety A benzofuryl C2-6 alkenyl group including both a trans isomer and a cis isomer (on the benzofuran ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 1 to 3 groups selected from the group consisting of 6 alkoxy groups may be substituted), a thiazolyl group [on the thiazole ring, 1 to 2 phenyl groups (on the phenyl ring, a halogen atom, 1 to 5, preferably 1 to 3 groups selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups Optionally substituted)] and a phenoxy C1-6 alkyl group in which the alkyl moiety is a linear or branched alkyl group having 1 to 6 carbon atoms (on the phenyl ring, halogen 1 to 5, preferably 1 to 3 groups selected from the group consisting of an atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. May be substituted with 1 to 3 groups selected from the group consisting of:

Benzothiazolidinyloxy group [on the benzothiazolidine ring, an oxo group and a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or non-substituted group) As at least one group selected from the group consisting of a group selected from the group consisting of substituted C1-6 alkoxy groups may be substituted] For example, (2-, 3-, 4-, 5-, 6- or 7-) benzothiazolidinyloxy group, 3- (4-trifluoromethoxybenzyl) -2-oxo- (4-, 5- , 6- or 7-) benzothiazolidinyloxy group, 3- (4-trifluoromethylbenzyl)-(2-, 4-, 5-, 6- or 7-) benzothiazolidinyloxy group, 3- (4- Rolobenzyl)-(2-, 4-, 5-, 6- or 7-) benzothiazolidinyloxy group, 3- (4-methylbenzyl)-(2-, 4-, 5-, 6- or 7) -) Benzothiazolidinyloxy group, 3- (3,4-dimethylbenzyl)-(2-, 4-, 5-, 6- or 7-) benzothiazolidinyloxy group, 3- (2, 4,6-trimethylbenzyl)-(2-, 4-, 5-, 6- or 7-) benzothiazolidinyloxy group, 3- (4-methoxybenzyl)-(2-, 4-, 5- , 6- or 7-) benzothiazolidinyloxy group, 3- (3,4-dimethoxybenzyl)-(2-, 4-, 5-, 6- or 7-) benzothiazolidinyloxy group, 3- (3,4,5-trimethoxybenzyl)-(2-, 4-, 5-, 6- or 7-) benzothiazolidinyl Xyl group, 3- (4-fluorobenzyl)-(2-, 4-, 5-, 6- or 7-) benzothiazolidinyloxy group, 3- (3,4-dichlorobenzyl)-(2- , 4-, 5-, 6- or 7-) benzothiazolidinyloxy group, 3- (2,4,6-trifluorobenzyl)-(2-, 4-, 5-, 6- or 7- ) Benzothiazolidinyloxy group, 2-oxo- (2-, 4-, 5-, 6- or 7-) benzothiazolidinyloxy group, 2,3-dibenzyl- (4-, 5-, 6- or 7-) benzothiazolidinyloxy group, 2,3,5-tribenzyl- (4-, 5-, 6- or 7-) benzothiazolidinyloxy group Group [on the benzothiazolidine ring, an oxo group and an alkyl moiety are linear or branched alkyls having 1 to 6 carbon atoms; A phenyl C1-6 alkyl group (which is selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group on the phenyl ring) 1 to 5 groups, preferably 1 to 3 groups may be substituted) may be substituted with 1 to 3 groups selected from the group consisting of]
An indolyloxy group [on the indole ring, at least one phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1 -6, which may be substituted with at least one group selected from the group consisting of alkoxy groups may be substituted, for example (1-, 2-, 3-, 4-, 5-, 6- or 7-) indolyloxy group, 1- (4-trifluoromethoxybenzyl)-(2-, 3-, 4-, 5-, 6- or 7-) indolyloxy group, 1 -(4-trifluoromethylbenzyl)-(2-, 3-, 4-, 5-, 6- or 7-) indolyloxy group, 1- (4-chlorobenzyl)-(2-, 3-, 4-, 5-, 6- or 7-) indolyl Group, 2- (4-methylbenzyl)-(1-, 3-, 4-, 5-, 6- or 7-) indolyloxy group, 3- (3,4-dimethylbenzyl)-(1-, 2-, 4-, 5-, 6- or 7-) indolyloxy group, 4- (2,4,6-trimethylbenzyl)-(1-, 2-, 3-, 5-, 6- or 7 -) Indolyloxy group, 5- (4-methoxybenzyl)-(1-, 2-, 3-, 4-, 6- or 7-) indolyloxy group, 6- (3,4-dimethoxybenzyl) -(1-, 2-, 3-, 4-, 5- or 7-) indolyloxy group, 7- (3,4,5-trimethoxybenzyl)-(1-, 2-, 3-, 4 -, 5- or 6-) indolyloxy group, 1- (4-fluorobenzyl)-(2-, 3-, 4-, 5-, 6- or 7-) indolyloxy group, -(3,4-dichlorobenzyl)-(2-, 3-, 4-, 5-, 6- or 7-) indolyloxy group, 1- (2,4,6-trifluorobenzyl)-(2 -, 3-, 4-, 5-, 6- or 7-) indolyloxy group, 1,3-dibenzyl- (2-, 4-, 5-, 6- or 7-) indolyloxy group, 1 , 3,5-tribenzyl- (2-, 4-, 6- or 7-) indolyloxy group or the like [on the indole ring, 1 to 3 alkyl moieties have 1 to 6 carbon atoms. A phenyl C1-6 alkyl group which is a linear or branched alkyl group of the above (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy 1 to 5, preferably 1 to 3 groups selected from the group consisting of groups Can be substituted) can be substituted].

  A pyrrolidinyl group [at least one amino group on the pyrrolidine ring (a C1-6 alkyl group on the amino group and a phenyl group (a halogen atom, halogen-substituted or unsubstituted C1-6 alkyl on the phenyl ring); Or at least one group selected from the group consisting of a group selected from the group consisting of a group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) Is preferably substituted)], for example, 3- [N-methyl-N- (3,4-dichlorophenyl) amino]-(1-, 2-, 4- or 5-) pyrrolidinyl group 3-amino- (1-, 2-, 4- or 5-) pyrrolidinyl group, 2,3-diamino- (1-, 4- or 5-) pyrrolidinyl group, 2,3,5-triamino- (1 -Or 4-) pyrrolidinyl , 3- [N-methyl-N- (4-methylphenyl) amino]-(1-, 2-, 4- or 5-) pyrrolidinyl group, 3- [N-ethyl-N- (3-methoxyphenyl) Amino]-(1-, 2-, 4- or 5-) pyrrolidinyl group, 3- [N- (4-trifluoromethylphenyl) amino]-(1-, 2-, 4- or 5-) pyrrolidinyl group , 3- [N- (4-trifluoromethoxyphenyl) amino]-(1-, 2-, 4- or 5-) pyrrolidinyl group, 3- [N-methyl-N- (3,4,5-tri Fluorophenyl) amino]-(1-, 2-, 4- or 5-) pyrrolidinyl group, 3- [N-methyl-N- (3-chloro-4-trifluoromethylphenyl) amino]-(1-, 2-, 4- or 5-) pyrrolidinyl group, 3- (N-phenylamino)-(1 2-, 4- or 5-) pyrrolidinyl group, 3-methylamino- (1-, 2-, 4- or 5-) pyrrolidinyl group, 3-dimethylamino- (1-, 2-, 4- or 5) -) A pyrrolidinyl group such as a pyrrolidinyl group [on the pyrrolidine ring, 1 to 3 amino groups (on the amino group a C1-6 alkyl group and a phenyl group (on the phenyl ring, a halogen atom, halogen substitution or A group selected from the group consisting of an unsubstituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted; 5 may be substituted, and preferably 1 to 3 may be substituted).

  As an indolinyl group (at least one halogen atom may be substituted on the indoline ring), for example, (1-, 2-, 3-, 4-, 5-, 6- or 7-) Indolinyl group, 5-bromo- (1-, 2-, 3-, 4-, 6- or 7-) indolinyl group, 4-chloro- (1-, 2-, 3-, 5-, 6- or 7 -) Indolinyl group, 6-fluoro- (1-, 2-, 3-, 4-, 5- or 7-) indolinyl group, 5,7-dichloro- (1-, 2-, 3-, 4- or 6) Indolinyl groups such as 3,5,6-trifluoro- (1-, 2-, 4- or 7-) indolinyl groups (1 to 3 halogen atoms are substituted on the indoline ring) Can be exemplified).

Indolinyloxy group [phenyl C1-6 alkyl group on indoline ring (on phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group And at least one group selected from the group consisting of oxo groups may be substituted]. For example, (1- , 2-, 3-, 4-, 5-, 6- or 7-) indolinyloxy group, 1- (4-trifluoromethoxybenzyl) -2,3-dioxo- (1-, 2-, 3- , 4-, 5-, 6- or 7-) indolinyloxy group, 1- (4-trifluoromethoxybenzyl) -2-oxo- (3-, 4-, 5-, 6- or 7-) indolini Nyloxy group, 1- (4 Trifluoromethylbenzyl)-(2-, 3-, 4-, 5-, 6- or 7-) indolinyloxy group, 1- (4-chlorobenzyl)-(2-, 3-, 4-, 5) -, 6- or 7-) indolinyloxy group, 3- (4-methylbenzyl)-(1-, 2-, 4-, 5-, 6- or 7-) indolinyloxy group, 4- (3 , 4-Dimethylbenzyl)-(1-, 2-, 3-, 5-, 6- or 7-) indolinyloxy group, 2- (2,4,6-trimethylbenzyl)-(1-, 3- , 4-, 5-, 6- or 7-) indolinyloxy group, 5- (4-methoxybenzyl)-(1-, 2-, 3-, 4-, 6- or 7-) indolinyloxy group , 6- (3,4-dimethoxybenzyl)-(1-, 2-, 3-, 4-, 5- or 7-) indolinyloxy group, 7- 3,4,5-trimethoxybenzyl)-(1-, 2-, 3-, 4-, 5- or 6-) indolinyloxy group, 1- (4-fluorobenzyl)-(2-, 3- , 4-, 5-, 6- or 7-) indolinyloxy group, 1- (3,4-dichlorobenzyl)-(2-, 3-, 4-, 5-, 6- or 7-) indolinyl Oxy group, 1- (2,4,6-trifluorobenzyl)-(2-, 3-, 4-, 5-, 6- or 7-) indolinyloxy group, 2-oxo- (1-, 3 -, 4-, 5-, 6- or 7-) indolinyloxy group, 1,3-dibenzyl- (2-, 4-, 5-, 6- or 7-) indolinyloxy group, 1, 5, 6-tribenzyl- (1-, 2-, 3-, 4
-Or 7-) an indolinyloxy group such as an indolinyloxy group, a 2,3-dioxo- (1-, 4-, 5-, 6- or 7-) indolinyloxy group [an alkyl moiety on the indoline ring; Is a C1-C6 linear or branched alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or 1 to 5, preferably 1 to 3 groups selected from the group consisting of substituted C1-6 alkoxy groups) and 1 to 3 groups selected from the group consisting of oxo groups May be substituted].

  The method for producing the compound of the present invention will be described in detail below.

[Wherein, R ¹ , R ² and n are the same as defined above. X ¹ represents a halogen atom or a nitro group. ]
According to the reaction process formula-1, the compound of the present invention represented by the general formula (1) and the 4-nitroimidazole compound represented by the general formula (2) in the presence or absence of the basic compound It is produced by reacting an epoxy compound represented by the general formula (3a) to obtain a compound represented by the general formula (4a), and then ring-closing the obtained compound represented by the general formula (4a). The

  The ratio of the compound of the general formula (2) and the compound of the general formula (3a) is usually 0.5 to 5 times mol, preferably 0.5 to 3 times mol of the latter with respect to the former. .

  As the basic compound, known compounds can be widely used, and examples thereof include inorganic basic compounds such as metal hydrides, metal alcoholates, hydroxides, carbonates, hydrogen carbonates, and organic basic compounds such as acetates. .

  Specific examples of the metal hydride include sodium hydride and potassium hydride. Specific examples of the metal alcoholate include sodium methoxide, sodium ethoxide, potassium tert-butoxide and the like. Specific examples of the hydroxide include sodium hydroxide and potassium hydroxide. Specific examples of the carbonate include sodium carbonate and potassium carbonate. Specific examples of the hydrogen carbonate include sodium hydrogen carbonate and potassium hydrogen carbonate. In addition to the above, the inorganic basic compound includes sodium amide and the like.

  Specific examples of the acetate include sodium acetate and potassium acetate. Specific examples of organic basic compounds other than the above include triethylamine, trimethylamine, diisopropylethylamine, pyridine, dimethylaniline, 1-methylpyrrolidine, N-methylmorpholine, 1,5-diazabicyclo [4.3.0] nonene. -5 (DBN), 1,8-diazabicyclo [5.4.0] undecene-7 (DBU), 1,4-diazabicyclo [2.2.2] octane (DABCO) and the like.

  Such a basic compound is usually used in an amount of 0.1 to 2 times mol, preferably 0.1 times to equimolar, more preferably 0.1 to 0.5 times mol, of the compound of the general formula (2). It is good.

  The reaction of the compound of general formula (2) and the compound of general formula (3a) is usually carried out in a suitable solvent.

  As the solvent, known solvents can be widely used as long as they do not inhibit the reaction. Examples of such solvents include aprotic polar solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), acetonitrile, ketone solvents such as acetone and methyl ethyl ketone, benzene, toluene, xylene, tetralin, liquid paraffin, and the like. Hydrocarbon solvents, alcohol solvents such as methanol, ethanol, isopropanol, n-butanol, tert-butanol, ether solvents such as tetrahydrofuran (THF), dioxane, dipropyl ether, diethyl ether, diglyme, ethyl acetate, acetic acid Examples thereof include ester solvents such as methyl, and mixed solvents thereof. These solvents may contain water.

  The reaction of the compound of the general formula (2) and the compound of the general formula (3a) is carried out, for example, by dissolving the compound of the general formula (2) in a reaction solvent and stirring with ice cooling or at room temperature (30 ° C.). After adding a basic compound and stirring at room temperature to 80 ° C. for 30 minutes to 1 hour, the compound of the general formula (3a) is added, and usually room temperature to 100 ° C., preferably 50 to 80 ° C. for 30 minutes to 60 hours, preferably Is carried out by continuing stirring for 1 to 50 hours.

  Compound (2) used as a raw material is a known compound. Compound (3a) includes a novel compound, and a method for producing the compound will be described later.

  The compound of the present invention represented by the general formula (1) is produced by subjecting the compound represented by the general formula (4a) to a ring-closing reaction. The ring closure reaction is carried out by dissolving the compound represented by the general formula (4a) obtained above in a reaction solvent, adding a basic compound and stirring.

  As a reaction solvent and a basic compound, the same thing as the reaction solvent and basic compound used by reaction with the compound of the said General formula (2) and the compound of General formula (3a) can be used.

  The usage-amount of a basic compound is normally equimolar-excess molar with respect to the compound of general formula (4a), Preferably it is 1-5 times mole, More preferably, it is 1-2 times mole.

  The reaction temperature of the ring closure reaction is usually 0 to 150 ° C, preferably room temperature to 120 ° C, more preferably 50 to 100 ° C. The reaction time is usually 30 minutes to 48 hours, preferably 1 to 24 hours, more preferably 1 to 12 hours.

  In the present invention, the reaction mixture can be subjected to the subsequent ring closure reaction without isolation of the compound of the general formula (4a) produced by the reaction of the compound of the general formula (2) and the compound of the general formula (3a). it can. For example, after reacting the compound of the general formula (2) and the compound of the general formula (3a) at room temperature to 80 ° C, a basic compound is added to the reaction mixture, and further stirring is performed at 50 to 100 ° C. Alternatively, after reacting the compound of the general formula (2) and the compound of the general formula (3a) at room temperature to 80 ° C., the reaction mixture is concentrated, the residue is dissolved in a high-boiling solvent, and the resulting solution is basic. The target compound represented by the general formula (1) can also be produced by adding the compound and further stirring at 50 to 100 ° C.

  Further, in the reaction of the compound of the general formula (2) and the compound of the general formula (3a), the basic compound is used in an amount of 0.9 to 2 moles with respect to the compound (2) and stirred at 50 to 100 ° C. Thus, the reaction of the compound of the general formula (2) and the compound of the general formula (3a) can be performed at once to produce the target compound represented by the general formula (1).

[Wherein X ¹ is the same as defined above. R ^1A represents a hydrogen atom or a C 1-6 alkyl group. R ^2A represents the above (a) to (y). ]
According to the reaction process formula-2, the compound of the present invention represented by the general formula (1w) is represented by the compound represented by the general formula (3b) and the general formula (5) in the presence of the basic compound. The compound represented by the general formula (4c) is obtained by reacting the compound or a salt thereof, and then the resulting compound represented by the general formula (4c) is cyclized.

  Compound (3b) is a novel compound, and a method for producing the compound will be described later (Reaction Process Formula-6). Compound (5) includes a novel compound, and an example of a method for producing the compound is shown in Reference Example 2 below.

  The use ratio of the compound of the general formula (3b) and the compound of the general formula (5) is usually 0.5 to 5 times mol, preferably 0.5 to 2 times mol of the latter with respect to the former. .

  The reaction of the compound of general formula (3b) and the compound of general formula (5) is carried out in a suitable solvent in the presence of a basic compound.

  As the basic compound and the reaction solvent, the same basic compounds and reaction solvents used in the reaction of the compound of the general formula (2) and the compound of the general formula (3a) can be used. The usage-amount of a basic compound is a catalyst amount normally with respect to the compound of general formula (3b), Preferably it is 0.1-3 times mole, More preferably, it is 0.1-2 times mole.

  Instead of using the compound (5) and the basic compound, a salt of the compound (5) can be used. Examples of such salts include alkali metal salts such as sodium salt and potassium salt of compound (5).

  The reaction of the compound of the general formula (3b) and the compound of the general formula (5) is usually performed at room temperature to 150 ° C, preferably room temperature to 120 ° C, more preferably room temperature to 80 ° C. The reaction time is usually 10 minutes to 48 hours, preferably 10 minutes to 24 hours, more preferably 10 minutes to 2 hours.

  The compound of the present invention represented by the general formula (1w) is produced by subjecting the compound represented by the general formula (4c) to a ring closure reaction. The ring-closing reaction is performed by dissolving the compound represented by the general formula (4c) obtained above in a reaction solvent, adding a basic compound, and stirring at a predetermined temperature.

  As the reaction solvent and the basic compound, the same reaction solvent and basic compound used in the reaction of the compound of the general formula (3b) and the compound of the general formula (5) can be used.

  The usage-amount of a basic compound is normally equimolar-excess molar with respect to the compound of general formula (4c), Preferably it is equimolar-5 times mole, More preferably, it is equimolar-2 times mole.

  The reaction temperature of the ring closure reaction is usually 0 to 150 ° C, preferably room temperature to 120 ° C, more preferably 50 to 100 ° C. The reaction time is usually 10 minutes to 48 hours, preferably 10 minutes to 24 hours, more preferably 20 minutes to 4 hours.

  In the present invention, the reaction mixture can be subjected to the subsequent ring closure reaction without isolation of the compound of the general formula (4c) produced by the reaction of the compound of the general formula (3b) and the compound of the general formula (5). Thus, the target compound of the present invention represented by the general formula (1w) can also be produced.

  When the basic compound is used in an equimolar to excess molar amount relative to the compound (5) and the reaction is carried out at 50 to 100 ° C., the intermediate (4c) is not isolated and the compound of the general formula (1w) is obtained. Manufactured at once. The same applies when an alkali metal salt (for example, sodium salt or potassium salt) of compound (5) is used.

[Wherein, R ^1A , R ^2A and n are the same as above. R ¹⁵ represents a C1-6 alkylsulfonyl group or a benzenesulfonyl group which may be substituted by a C1-6 alkyl group. ]
Here, the C1-6 alkylsulfonyl group is a group composed of an alkyl group composed of 1 to 6 carbon atoms and a sulfonyl group, such as a methanesulfonyl group, an ethanesulfonyl group, a propanesulfonyl group, Examples include butanesulfonyl group, pentanesulfonyl group, hexanesulfonyl group and the like.

  Examples of the benzenesulfonyl group that the C1-6 alkyl group may be substituted include, for example, a benzenesulfonyl group, o-toluenesulfonyl group, m-toluenesulfonyl group, p-toluenesulfonyl group, 2-ethylbenzenesulfonyl group, 3- Ethylbenzenesulfonyl group, 4-ethylbenzenesulfonyl group, 2-propylbenzenesulfonyl group, 3-propylbenzenesulfonyl group, 4-propylbenzenesulfonyl group, 2,3-dimethylbenzenesulfonyl group, 2,4-dimethylbenzenesulfonyl group, 2 Examples thereof include benzenesulfonyl groups which may be substituted with 1 to 3 C1-6 alkyl groups such as 1,4,6-trimethylbenzenesulfonyl group.

  The reaction of compound (6) and compound (5) is carried out in a suitable solvent in the presence of a basic compound.

  As the solvent to be used, any known solvent can be used as long as it does not inhibit this reaction. Examples of such solvents include aprotic polar solvents such as water, DMF, DMSO, and acetonitrile, hydrocarbon solvents such as benzene, toluene, xylene, tetralin, liquid paraffin, and cyclohexane, ethanol, isopropanol, and n-butanol. And alcohol solvents such as tert-butanol, ether solvents such as THF, dioxane, dipropyl ether, diethyl ether and diglyme, ethyl acetate, acetone and the like, or a mixed solvent thereof.

  As the basic compound, the same basic compound as used in the reaction of the compound of the general formula (2) and the compound of the general formula (3a) can be used.

  The amount of the basic compound to be used is generally equimolar to excess molar, preferably 1 to 5 molar, more preferably 1 to 2 molar relative to compound (6).

  Compound (5) may be used in an amount of usually equimolar to excess molar, preferably 0.9 to 2 molar, more preferably 0.9 to 1.5 molar relative to compound (6).

  The reaction temperature is generally room temperature to 150 ° C, preferably room temperature to 100 ° C, more preferably 60 to 100 ° C. The reaction time is usually 10 minutes to 24 hours, preferably 10 minutes to 12 hours, more preferably 20 minutes to 7 hours.

  Next, a method for producing starting materials and intermediates for producing the compound of the present invention will be described.

[Wherein, R ^1A , R ¹⁵ and n are the same as defined above. R ¹⁶ represents a C 1-6 alkoxy-C 1-6 alkoxy group or a C 1-6 alkanoyloxy group. X ² represents a halogen atom. ]
Compound (8) is produced by hydrolyzing compound (7).

  The hydrolysis reaction is performed under acidic conditions. For example, it is carried out by adding an acid to a solution obtained by suspending or dissolving the compound (7) in a suitable solvent and stirring at 0 to 120 ° C. Examples of the solvent used include alcohol solvents such as water, methanol, ethanol, isopropanol, and ethylene glycol, acetonitrile, acetone, toluene, DMF, DMSO, acetic acid, trifluoroacetic acid, and mixed solvents thereof. . Examples of the acid used include organic acids such as trifluoroacetic acid and acetic acid, and inorganic acids such as hydrochloric acid, bromic acid, hydrobromic acid and sulfuric acid. Organic acids such as trifluoroacetic acid and acetic acid can themselves be used as reaction solvents. The reaction temperature is generally 0 to 120 ° C, preferably room temperature to 100 ° C, more preferably room temperature to 80 ° C. The reaction time is usually 30 minutes to 24 hours, preferably 30 minutes to 12 hours, more preferably 1 to 8 hours.

  Hydrolysis of compound (7) can also be carried out under basic conditions. For example, it is carried out by adding a base to a solution obtained by suspending or dissolving the compound (7) in a suitable solvent and stirring at 0 to 120 ° C. The solvent used is, for example, water, methanol, ethanol, isopropanol, ethylene glycol or other alcohol solvents, or a mixed solvent thereof. Examples of the base used include alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, alkali metal carbonates such as sodium carbonate and potassium carbonate, and acetates such as sodium acetate. The reaction temperature is 0 to 120 ° C, preferably room temperature to 100 ° C, more preferably room temperature to 80 ° C. The reaction time is 30 minutes to 24 hours, preferably 30 minutes to 12 hours, more preferably 1 to 8 hours.

  The reaction conditions of the alcohol sulfonylation reaction generally performed can be widely applied to the reaction between the compound (8) and the compound (9). For example, compound (8) can be obtained by dissolving compound (8) in an appropriate solvent, adding compound (9) to this solution in the presence of a basic compound, and stirring at 0 to 150 ° C.

  As the solvent to be used, any known solvent can be used as long as it does not inhibit the sulfonylation reaction. Examples of such solvents include halogenated hydrocarbon solvents such as methylene chloride and chloroform, aprotic polar solvents such as DMF, DMSO, and acetonitrile, aromatic hydrocarbon solvents such as benzene, toluene and xylene, tetralin And hydrocarbon solvents such as liquid paraffin and cyclohexane, ether solvents such as THF, dioxane, dipropyl ether, diethyl ether and diglyme, ethyl acetate, acetone and the like, or a mixed solvent thereof.

  Compound (9) may be used in an amount of usually equimolar to excess molar, preferably equimolar to 2-fold molar, more preferably equimolar to 1.1-fold molar relative to Compound (8).

  As the basic compound, the same basic compound as used in the reaction of the compound of the general formula (2) and the compound of the general formula (3a) can be used.

  The amount of the basic compound to be used is generally equimolar to excess molar, preferably 1 to 5 molar, more preferably 1 to 2 molar relative to compound (8).

  In this sulfonylation reaction, 4-dimethylaminopyridine, 4- (1-pyrrolidinyl) pyridine and the like can be used as a catalyst.

  The reaction temperature is generally 0 to 150 ° C., preferably 0 to 100 ° C., more preferably 0 to 60 ° C. The reaction time is usually 30 minutes to 48 hours, preferably 1 to 24 hours, more preferably 1 to 4 hours.

[Wherein, R ^1A , R ^2A , R ¹⁵ , X ¹ and n are the same as defined above. ]
The reaction leading from compound (4b) to compound (10) is carried out, for example, under the same reaction conditions as the reaction leading from compound (8) to compound (6) in Reaction Process Formula-4.

  The reaction leading from compound (10) to compound (4c) is performed, for example, under the same reaction conditions as the reaction leading from compound (6) to compound (1w) in Reaction Process Formula-3.

[Wherein, R ^1A , R ¹⁵ and X ¹ are the same as above. ]
The reaction leading from compound (10a) to compound (3b) is carried out in a suitable solvent in the presence of a basic compound.

  As the solvent that can be used here, a solvent that does not inhibit the reaction can be widely used. Examples of such solvents include aprotic polar solvents such as DMSO and acetonitrile, hydrocarbon solvents such as benzene, toluene, xylene, tetralin and liquid paraffin, and halogenated hydrocarbons such as methylene chloride, chloroform and dichloroethane. Examples of the solvent include ether solvents such as THF, dioxane, dipropyl ether, diethyl ether, and diglyme, acetone, ethyl acetate, and the above mixed solvents.

  As the basic compound, the same basic compound as used in the reaction of the compound of the general formula (2) and the compound of the general formula (3a) can be used.

  The basic compound is usually used in an equimolar to excess molar amount, preferably 1 to 5 times mol, more preferably 1 to 2 times mol, relative to compound (10a).

  The reaction temperature of this reaction is usually 0 to 150 ° C, preferably 0 to 100 ° C, more preferably 0 to 60 ° C. Moreover, reaction time is 30 minutes-48 hours normally, Preferably it is 1 to 24 hours, More preferably, it is 1 to 4 hours.

[Wherein, R ¹ , R ² and n are the same as defined above. ]
The reaction leading from compound (11) to compound (3a) is carried out, for example, by treating compound (11) with trimethylsulfoxonium iodide in the presence of a basic compound in a suitable solvent.

  As the solvent that can be used here, a solvent that does not inhibit the reaction can be widely used. Examples of such solvents include aprotic polar solvents such as DMSO and acetonitrile, hydrocarbon solvents such as benzene, toluene, xylene, tetralin and liquid paraffin, THF, dioxane, dipropyl ether, diethyl ether, diglyme and the like. Or an ether solvent of the above or a mixed solvent thereof.

  Examples of the basic compound include metal alcoholates such as sodium hydride, sodium amide, sodium methoxide, sodium ethoxide, potassium tert-butoxide and the like.

  These basic compounds are usually used in an equimolar to excess molar amount, preferably 1 to 3 molar times, more preferably 1 to 1.5 molar times with respect to compound (11).

  Trimethylsulfoxonium iodide is usually used in an equimolar to excess molar amount, preferably 1 to 3 molar times, and more preferably 1 to 1.5 molar times with respect to compound (11).

  The reaction temperature of this reaction is usually 0 to 80 ° C, preferably 10 to 50 ° C, more preferably 20 to 35 ° C. Moreover, reaction time is 1 to 24 hours normally, Preferably it is 1 to 12 hours, More preferably, it is 1 to 4 hours.

  The reaction leading from compound (12) to compound (3a) is performed, for example, by treating compound (12) with a peroxide in a suitable solvent.

  As the reaction solvent that can be used here, a wide variety of solvents that do not inhibit the reaction can be used. Examples of such solvents include alcohol solvents such as water, methanol, and ethanol, aprotic polar solvents such as DMF, DMSO, and acetonitrile, and hydrocarbon solvents such as benzene, toluene, xylene, tetralin, liquid paraffin, and cyclohexane. Examples thereof include solvents, halogenated hydrocarbon solvents such as methylene chloride, chloroform and dichloroethane, ether solvents such as THF, dioxane, dipropyl ether, diethyl ether and diglyme, and the above mixed solvents.

  Examples of the peroxide include metachloroperbenzoic acid (mCPBA), perbenzoic acid, peracetic acid, hydrogen peroxide, and the like.

  These peroxides may be used in an amount of usually equimolar to 2-fold mole, preferably equimolar to 1.5-fold mole, more preferably equimolar to 1.3-fold mole relative to compound (12).

  The reaction temperature of this reaction is usually 0 to 80 ° C, preferably 0 to 50 ° C, more preferably 20 to 35 ° C. Moreover, reaction time is 10 minutes-24 hours normally, Preferably it is 1 to 12 hours, More preferably, it is 1 to 8 hours.

  The optically active compound (3a) is produced, for example, from the compound (12) as follows.

In the optically active compound (3a), cumene hydroperoxide or tert-butyl hydroperoxide is used instead of the peroxide used in the reaction leading from the compound (12) to the compound (3a), and a catalyst (for example, Ti ( O-iso-C ₃ H ₇ ) ₄ and optically active tartaric acid C1-6 alkyl esters such as diethyl tartrate (D or L-form)) can be produced by so-called Sharpless oxidation.

  As a solvent used in this reaction, a solvent that does not inhibit this reaction can be widely used. Examples of such solvents include aprotic polar solvents such as acetonitrile, hydrocarbon solvents such as benzene, toluene, xylene, tetralin, liquid paraffin, and cyclohexane, and halogenated hydrocarbons such as methylene chloride, chloroform, and dichloroethane. Examples of the solvent include ether solvents such as THF, dioxane, dipropyl ether, diethyl ether, and diglyme, and mixed solvents thereof.

  Cumene hydroperoxide or tert-butyl hydroperoxide is generally 0.1 mol to 2 times mol, preferably 0.1 mol to 1.5 times mol, more preferably 0.1 times the compound (6). ~ Equimolar may be used.

Ti (O-iso-C ₃ H ₇ ) ₄ is usually 0.1 to 2 times mol, preferably 0.1 to 1.5 times mol, more preferably 0.1 times the compound (12). What is necessary is just to use mol-equimolar.

  The optically active tartaric acid C1-6 alkyl ester (D or L-form) is usually equimolar to 2-fold mol, preferably equimolar to 1.5-fold mol, more preferably equal to compound (12). What is necessary is just to use mol-1.3 times mole.

  The reaction temperature of this reaction is usually −50 to 30 ° C., preferably −20 to 20 ° C., more preferably −20 to 5 ° C. Moreover, reaction time is 1 to 48 hours normally, Preferably it is 4 to 24 hours, More preferably, it is 4 to 12 hours.

[Wherein, R ^1A , R ^2A , R ¹⁵ and n are the same as defined above. ]
The reaction leading from compound (13) to compound (3c) is performed, for example, under the same reaction conditions as the reaction leading from compound (6) to compound (1w) in Reaction Process Formula-3.

[Wherein, R ^1A , X, n, m, W and o are the same as above. R ^7a represents a hydrogen atom, a hydroxyl group, a C 1-6 alkoxy group or a phenyl group (a halogen atom may be substituted on the phenyl ring). The dotted line on the piperidine ring indicates that it may be a double bond. When the dotted line is a double bond, a hydroxyl group is substituted on the piperidine ring. R ^6a represents a tetrahydropyranyloxy group. R ¹⁷ represents a C1-6 alkyl group or a phenyl group (on the phenyl ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group). At least one selected group may be substituted). M represents an alkali metal such as sodium or potassium. ]
The reaction for converting compound (14) to compound (15) is carried out in the presence of an acid in a suitable solvent or without solvent.

  Any solvent that does not affect the reaction can be used, such as water, halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, lower alcohols such as methanol, ethanol, isopropanol, acetone, methyl ethyl ketone, etc. Ketones, dioxane, tetrahydrofuran, ethers such as ethylene glycol monomethyl ether and ethylene glycol dimethyl ether, fatty acids such as formic acid and acetic acid, mixed solvents thereof and the like.

  Examples of the acid include mineral acids such as hydrochloric acid, sulfuric acid and hydrobromic acid, and organic acids such as formic acid, trifluoroacetic acid, acetic acid, pyridinium p-toluenesulfonic acid, and aromatic sulfonic acids such as p-toluenesulfonic acid. be able to. Although the usage-amount of an acid is not specifically limited and can be suitably selected from a wide range, Usually, about 0.1-10 mol with respect to 1 mol of compounds (14), Preferably it is about 0.1-2 mol. .

  The reaction normally proceeds suitably at about 0 to 200 ° C., preferably at room temperature to about 150 ° C., and the reaction is usually completed in about 0.5 to 50 hours.

  The reaction of compound (15) with compound (16) or (17) is carried out in the presence or absence of a basic compound, preferably in the absence of a suitable inert solvent or without solvent.

  Examples of the basic compound used here include triethylamine, trimethylamine, pyridine, dimethylaniline, N-ethyldiisopropylamine, dimethylaminopyridine, N-methylmorpholine, 1,5-diazabicyclo [4.3.0] nonene-5. (DBN), 1,8-diazabicyclo [5.4.0] undecene-7 (DBU), 1,4-diazabicyclo "[2.2.2] octane (DABCO) and other organic bases, sodium carbonate, potassium carbonate , Carbonates such as sodium bicarbonate, potassium bicarbonate, metal hydroxides such as sodium hydroxide, potassium hydroxide, calcium hydroxide, potassium hydride, sodium hydride, potassium, sodium, sodium amide, sodium methylate, Metal alcoholates such as sodium ethylate Inorganic bases.

  Examples of the solvent used include halogenated hydrocarbons such as chloroform, dichloromethane, dichloroethane, and carbon tetrachloride, aromatic hydrocarbons such as benzene, toluene, and xylene, diethyl ether, diisopropyl ether, tetrahydrofuran, dimethoxyethane, and the like. Ethers, esters such as methyl acetate, ethyl acetate, isopropyl acetate, methanol, ethanol, isopropanol, propanol, butanol, alcohols such as 3-methoxy-1-butanol, ethyl cellosolve, methyl cellosolve, acetonitrile, pyridine, acetone, Aprotic polar solvents such as water, N, N-dimethylacetamide, N, N-dimethylformamide, dimethyl sulfoxide, hexamethylphosphoric triamide or a mixed solvent thereof may be mentioned. .

  The amount of compound (16) or (17) to be used is usually about equimolar to about 5 times molar amount, preferably about about equimolar to about 3 times molar amount with respect to compound (15).

  The reaction is usually carried out at a temperature of about 0 to 200 ° C., preferably about room temperature to about 150 ° C., usually taking about 5 minutes to 30 hours.

  Boron compounds such as boron trifluoride diethyl ether complex, copper halide compounds such as cuprous chloride, and the like may be added to the reaction system of the reaction.

  In the reaction of compound (15) and compound (17), the reaction proceeds advantageously when an organic acid such as trifluoroacetic acid is added to the reaction system.

[Wherein, R ^1A , X, n, m, W, R ^7a , X ² and o are the same as above. Two W in the general formulas (1c) to (1g) may be the same or different.
R ^9a represents a hydrogen atom.

R ^10a is a hydrogen atom; a C 1-6 alkyl group which may have a hydroxyl group as a substituent; a C 1-6 alkanoyl group; a C 1-6 alkoxycarbonyl group; a phenyl C 1-6 alkoxycarbonyl group (on the phenyl ring, a substituent At least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group as a group may be substituted); phenyl Group (on the phenyl ring, a halogen atom as a substituent, a halogen-substituted or unsubstituted C1-6 alkyl group, a halogen-substituted or unsubstituted C1-6 alkoxy group, a C1-6 alkanoyl group and C1-6 as a substituent) An amino group that may have a group selected from the group consisting of alkyl groups, a C1-6 alkoxycarbonyl group, a phenyl group, A phenoxy group (on the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. An aminosulfonyl group, 1,2,3,4-tetrahydroquinolyl group (on the 1,2,3,4-tetrahydroquinoline ring, at least one oxo group is substituted as a substituent). C1-6 alkylsulfonyl group, C3-8 cycloalkyl group, nitro group, cyano group, C1-6 alkylthio group; phenylsulfonyl group (on the phenyl ring, a halogen atom, halogen-substituted or At least one selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. And may be), hydroxy-substituted C1~6 alkyl group and group

(W ₁ represents a C 1-6 alkylene group. R ¹¹ and R ¹² are the same or different and represent a C 1-6 alkoxy group) and at least one group selected from the group consisting of is substituted. A phenyl C1-6 alkyl group (on the phenyl ring, a C1-4 alkylenedioxy group as a substituent, a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl) At least one selected from the group consisting of a group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), a group —N (R ^11A ) R ^12A (R ^11A and R ^12A are the same) Or a hydrogen atom, a C1-6 alkyl group or a phenyl group, and R ^11A and R ^12A together with the adjacent nitrogen atom are bonded to each other through or without a nitrogen atom, oxygen atom or sulfur atom. A 7-membered saturated heterocyclic ring), a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one selected from the group consisting of: a phenyl C1-6 alkoxy group, an amino group-substituted C1-6 alkoxy group that may have a C1-6 alkyl group as a substituent, a halogen atom , At least one group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-10 alkoxy group may be substituted); benzofuryl C1-6 alkyl A group [on the benzofuran ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkyl; At least one group selected from the group consisting of a xy group may be substituted]; a phenylsulfonyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, a halogen-substituted group) Or at least one group selected from the group consisting of an unsubstituted C1-6 alkoxy group and a C1-4 alkylenedioxy group may be substituted; a phenoxycarbonyl group (on the phenyl ring, a substituent A halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted); phenyl C2 -6 alkenyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C At least one group selected from the group consisting of ˜6 alkoxy groups may be substituted); C1-6 alkoxy substituted C1-6 alkyl groups; C2-6 alkenyl groups; C1-6 alkoxy substituted C2-6 An alkanoyl group; a C3-8 cycloalkyl-substituted C1-6 alkyl group; a phenoxy C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1 -6 at least one group selected from the group consisting of alkoxy groups may be substituted; a benzoyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen) At least one group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted); Moyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. A pyridyl group; a pyridyl C1-6 alkyl group; an imidazolyl C1-6 alkyl group; a 1,2,3,4-tetrahydroquinolyl group (on a 1,2,3,4-tetrahydroquinoline ring); And at least one group selected from the group consisting of an oxo group and a C1-6 alkyl group as a substituent may be substituted); a quinolyl group; an indolyl group; a C1-6 alkyl group as a substituent Indazolyl group; naphthyl group; C3-8 cycloalkyl group; amino-substituted C1-6a which may have a C1-6 alkyl group as a substituent Kill group; cyano C1~6 alkyl group; furyl substituted C1~6 alkyl group, group

[RR represents a phenyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. Species may be substituted). Or a piperazinyl-substituted C1-6 alkyl group (on the piperazine ring at least one phenyl group as a substituent [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or And at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted].

R ^9b is a hydrogen atom; a C 1-6 alkyl group which may have a hydroxyl group as a substituent; a phenyl group (on the phenyl ring, a C 1-4 alkylenedioxy group as a substituent, a phenyl group (on the phenyl ring). At least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group), a group -N ( R ^11A ) R ^12A (R ^11A and R ^12A are the same or different and each represents a hydrogen atom, a C 1-6 alkyl group or a phenyl group. R ^11A and R ^12A together with the adjacent nitrogen atom, a nitrogen atom, an oxygen atom or A 5- to 7-membered saturated heterocyclic ring may be bonded to each other via or not via a sulfur atom), a phenoxy group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted At least one selected from the group consisting of a C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group), a phenyl C1-6 alkoxy group, and C1-6 as a substituent A group selected from the group consisting of an amino group-substituted C1-6 alkoxy group which may have an alkyl group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-10 alkoxy group A phenyl C1-6 alkyl group (on the phenyl ring, a C1-4 alkylenedioxy group as a substituent, a phenyl group (on the phenyl ring, a halogen atom, a halogen atom) At least one selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group The species may be substituted), a group —N (R ^11A ) R ^12A (R ^11A and R ^12A are the same or different and represent a hydrogen atom, a C 1-6 alkyl group or a phenyl group. R ^11A and R ^12A. May be bonded to each other together with or without an adjacent nitrogen atom via a nitrogen atom, oxygen atom or sulfur atom to form a 5- to 7-membered saturated heterocyclic ring), a phenoxy group (on the phenyl ring) , A halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), phenyl C1-6 Alkoxy group, amino group-substituted C1-6 alkoxy group which may have C1-6 alkyl group as a substituent, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted May be substituted with at least one group selected from the group consisting of unsubstituted C1-10 alkoxy groups); benzofuryl [on the benzofuran ring, halogen atoms, halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of an alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]; a benzofuryl C1-6 alkyl group [on the benzofuran ring, a halogen atom; , At least one selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]; C1-6 alkoxy substituted A C3-6 alkyl group; a C3-8 cycloalkyl-substituted C1-6 alkyl group; a C3-8 cycloalkyl group; a phenoxy C1-6 alkyl group ( On the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. Good); pyridyl group; pyridyl C1-6 alkyl group; imidazolyl group; imidazolyl C1-6 alkyl group; amino substituted C1-6 alkyl group which may have C1-6 alkyl group as a substituent; cyano substituted C1-6 alkyl Group: furyl-substituted C1-6 alkyl group; furyl group; piperazinyl group (on the piperazine ring, at least one phenyl group as a substituent [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 At least one selected from the group consisting of an alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. May be substituted) or a piperazinyl-substituted C1-6 alkyl group (on the piperazine ring, at least one phenyl group as a substituent [on the phenyl ring, a halogen atom, halogen-substituted or At least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]. .

R ^9c is a C1-6 alkyl group which may have a hydroxyl group as a substituent; a C1-6 alkoxycarbonyl group; a phenyl C1-6 alkoxycarbonyl group (on the phenyl ring, a halogen atom, halogen-substituted or At least one group selected from the group consisting of a substituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted; a phenyl group (on the phenyl ring, The substituent is selected from the group consisting of a halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group, halogen-substituted or unsubstituted C1-6 alkoxy group, C1-6 alkanoyl group and C1-6 alkyl group as substituents. May have an amino group, a C1-6 alkoxycarbonyl group, a phenyl group, a phenoxy group (on the phenyl ring, At least one selected from the group consisting of a rogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group), an aminosulfonyl group 1,2,3,4-tetrahydroquinolyl group (on the 1,2,3,4-tetrahydroquinoline ring, at least one oxo group may be substituted as a substituent), C1-6 alkyl A sulfonyl group, a C3-8 cycloalkyl group, a nitro group, a cyano group, a C1-6 alkylthio group; a phenylsulfonyl group (on the phenyl ring, a halogen atom as a substituent, a halogen-substituted or unsubstituted C1-6 alkyl group and At least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted), hydroxyl-substituted C1 6 alkyl group and group

(W ₁ represents a C 1-6 alkylene group. R ¹¹ and R ¹² are the same or different and represent a C 1-6 alkoxy group.) Even if at least one group selected from the group consisting of A phenyl C1-6 alkyl group (on the phenyl ring, a C1-4 alkylenedioxy group as a substituent, a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group). And at least one selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted), a group —N (R ^11A ) R ^12A (R ^11A and R ^12A are the same or Differently, it represents a hydrogen atom, a C1-6 alkyl group or a phenyl group, and R ^11A and R ^12A are bonded to each other together with or without a nitrogen atom, oxygen atom or sulfur atom together with an adjacent nitrogen atom. Or a phenoxy group (on the phenyl ring, consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one selected from the group may be substituted), a phenyl C1-6 alkoxy group, an amino group-substituted C1-6 alkoxy group that may have a C1-6 alkyl group as a substituent, a halogen atom, a halogen At least one selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-10 alkoxy group may be substituted); a benzofuryl C1-6 alkyl group [ On the benzofuran ring, there are a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy. At least one group selected from the group consisting of groups may be substituted]; phenylsulfonyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group, halogen-substituted or At least one group selected from the group consisting of an unsubstituted C1-6 alkoxy group and a C1-4 alkylenedioxy group may be substituted; a phenyl C2-6 alkenyl group (on the phenyl ring, At least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted); C1-6 Alkoxy substituted C1-6 alkyl group; C2-6 alkenyl group; C3-8 cycloalkyl group substituted C1-6 alkyl group; phenoxy C1-6 alkyl group On the nyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. A pyridyl group; a pyridyl C1-6 alkyl group; an imidazolyl C1-6 alkyl group; a 1,2,3,4-tetrahydroquinolyl group (on the 1,2,3,4-tetrahydroquinoline ring, a substituent); At least one selected from the group consisting of an oxo group and a C1-6 alkyl group may be substituted); a quinolyl group; an indolyl group; an indazolyl group; a naphthyl group; a C3-8 cycloalkyl group; An amino-substituted C1-6 alkyl group which may have a C1-6 alkyl group as a group; a cyano-substituted C1-6 alkyl group; a furyl-substituted C1-6 alkyl group, a group

[RR represents a phenyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. Species may be substituted). Or a piperazinyl-substituted C1-6 alkyl group (on the piperazine ring at least one phenyl group as a substituent [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or And at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted].

R ^9d is a C1-6 alkanoyl group; a phenoxycarbonyl group (on the phenyl ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one selected group may be substituted); C1-6 alkoxy-substituted C2-6 alkanoyl group or benzoyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl) And at least one group selected from the group consisting of a group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted).

R ^9e represents a phenyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C 1-6 alkyl group and a halogen-substituted or unsubstituted C 1-6 alkoxy group). Species may be substituted).

R ¹⁸ represents a hydrogen atom or a C1-6 alkyl group.

The dotted line on the piperidine ring indicates that it may be a double bond. When the dotted line is a double bond, the group-(W) oNR ^9a R ^10a , group-(W) oN (CHR ¹⁸ R ^9b ) R ^10a , group-(W) oNR ^9c R ^10a , group-(W) oNR ^9d R ^10a or the group — (W) oN (CONHR ^9e ) R ^10a shall be substituted.

The total number of carbon atoms of CHR ¹⁸ R ^9b constituting the group —N (R ^10a ) CHR ¹⁸ R ^9b in the general formula (1d) shall not exceed 6. ]
The reaction between compound (1c) and compound (16) is carried out in the presence of a reducing agent in the absence of a solvent or in a suitable solvent.

  The amount of compound (16) to be used is usually at least equimolar amount, preferably equimolar to large excess amount relative to compound (1c).

  Examples of the solvent used in the reaction include water, lower alcohols such as methanol, ethanol, isopropanol, butanol, tert-butanol, and ethylene glycol, fatty acids such as acetonitrile, formic acid, acetic acid, and trifluoroacetic acid, diethyl ether, Examples include ethers such as tetrahydrofuran, dioxane, monoglyme and diglyme, aromatic hydrocarbons such as benzene, toluene and xylene, halogenated hydrocarbons such as dichloromethane, dichloroethane, chloroform and carbon tetrachloride, or a mixed solvent thereof. .

  Examples of the reducing agent include alkali metal salts of formic acid such as formic acid and sodium formate, sodium borohydride, sodium cyanoborohydride, sodium triacetyloxyborohydride, lithium aluminum hydride and the like, or these Examples thereof include a mixture of hydrogenation reducing agents, a catalytic hydrogen reducing agent such as palladium-black, palladium-carbon, platinum oxide, platinum black, and Raney nickel.

  When formic acid and alkali metal formate are used as the reducing agent, the reaction temperature is usually room temperature to about 200 ° C., preferably about 50 to 150 ° C., and the reaction is completed in about 10 minutes to 10 hours. The formic acid is preferably used in a large excess with respect to compound (1c).

  When a hydrogenation reducing agent is used, the reaction temperature is usually about −80 to 100 ° C., preferably about −80 to 70 ° C., and the reaction is completed in about 30 minutes to 100 hours. The amount of the hydrogenation reducing agent to be used is generally about equimolar to 20 times molar amount, preferably about equimolar to 6 times molar relative to compound (1c). In particular, when lithium aluminum hydride is used as the hydrogenation reducing agent, it is preferable to use ethers such as diethyl ether, tetrahydrofuran, dioxane, monoglyme and diglyme, and aromatic hydrocarbons such as benzene, toluene and xylene as the solvent. . In the reaction system, amines such as trimethylamine, triethylamine, N-ethyldiisopropylamine, molecular sieves such as molecular sieve 3A (MS-3A), molecular sieve 4A (MS-4A), etc. may be added. Good.

  Further, when a catalytic hydrogen reducing agent is used, it is usually in a hydrogen atmosphere at about normal pressure to about 20 atm, preferably about normal pressure to about 10 atm, or a hydrogen donating agent such as formic acid, ammonium formate, cyclohexene, or dehydrating hydrazine. In the presence, the reaction is usually performed at a temperature of about -30 to 100 ° C, preferably about 0 to 60 ° C, and the reaction is usually completed in about 1 to 12 hours. The amount of the catalytic hydrogen reducing agent used is usually 0.1 to 40% by weight, preferably about 1 to 20% by weight, based on the compound (1c).

  The reaction of compound (1c) and compound (17) is generally carried out in a suitable solvent in the presence or absence of a basic compound.

  Examples of the inert solvent used include aromatic hydrocarbons such as benzene, toluene and xylene, ethers such as diethyl ether, tetrahydrofuran, dioxane, monoglyme and diglyme, and halogens such as dichloromethane, dichloroethane, chloroform and carbon tetrachloride. Hydrocarbons, methanol, ethanol, isopropanol, butanol, tert-butanol, lower alcohols such as ethylene glycol, fatty acids such as acetic acid, esters such as ethyl acetate and methyl acetate, ketones such as acetone and methyl ethyl ketone, acetonitrile, Examples thereof include pyridine, dimethyl sulfoxide, N, N-dimethylformamide, hexamethylphosphoric triamide or a mixed solvent thereof.

  Examples of basic compounds include carbonates such as sodium carbonate, potassium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, cesium carbonate, metal hydroxides such as sodium hydroxide, potassium hydroxide, calcium hydroxide, sodium hydride, and the like. , Potassium hydride, potassium, sodium, sodium amide, sodium methylate, sodium ethylate, sodium metal alcoholates such as n-butoxide, pyridine, imidazole, N-ethyldiisopropylamine, dimethylaminopyridine, triethylamine, trimethylamine, dimethylaniline , N-methylmorpholine, 1,5-diazabicyclo [4.3,0] nonene-5 (DBN), 1,8-diazabicyclo [5.4.0] undecene-7 (DBU), 1,4-diazabicyclo [ 2.2. ] Can be exemplified organic bases or mixtures thereof, such as octane (DABCO).

  The basic compound is used in an amount of at least an equimolar amount, preferably an equimolar to 10-fold molar amount relative to the compound (1c).

  Compound (17) is used in an amount of at least equimolar amount, preferably equimolar to 10-fold molar amount relative to compound (1c).

  The reaction is usually carried out at 0 to 200 ° C., preferably about 0 to 150 ° C., and the reaction is generally completed in about 5 minutes to 80 hours.

  Alkali metal halogen compounds such as sodium iodide and potassium iodide may be added to the reaction system, or a phase transfer catalyst may be added.

  Here, examples of the phase transfer catalyst include tetrabutylammonium chloride, tetrabutylammonium bromide, tetrabutylammonium fluoride, tetrabutylammonium iodide, tetrabutylammonium hydroxide, tetrabutylammonium hydrogen sulfite, tributylmethylammonium chloride, tributyl. Benzylammonium chloride, tetrapentylammonium chloride, tetrapentylammonium bromide, tetrahexylammonium chloride, benzyldimethyloctylammonium chloride, methyltrihexylammonium chloride, benzyldimethyloctadecanylammonium chloride, methyltridecanylammonium chloride, benzyltripropylammonium Chloride, benz Selected from the group consisting of linear or branched alkyl groups having 1 to 18 carbon atoms, such as triethylammonium chloride, phenyltriethylammonium chloride, tetraethylammonium chloride, tetramethylammonium chloride, phenyl C1-6 alkyl groups and phenyl groups A quaternary ammonium salt substituted with a substituted group, a phosphonium salt substituted with a linear or branched alkyl group having 1 to 18 carbon atoms such as tetrabutylphosphonium chloride, and a carbon number of 1 such as 1-dodecanylpyridinium chloride Examples include pyridinium salts substituted with 18 to 18 linear or branched alkyl groups.

  The amount of the phase transfer catalyst to be used is generally 0.1-fold mol to equimolar amount, preferably 0.1 to 0.5-fold mol amount based on compound (1c).

  The reaction between the compound (1c) and the compound (18) is a method in which the compound (1c) and the carboxylic acid of the compound (18) are reacted in a usual amide bond forming reaction.

  For the amide bond formation reaction, known conditions for amide bond formation reaction can be widely applied. For example, (a) a mixed acid anhydride method, that is, a method in which a carboxylic acid (18) is reacted with an alkylhalocarboxylic acid to form a mixed acid anhydride, and this is reacted with an amine (1c), (b) an active ester method, Carboxylic acid (18) is an active amide such as p-nitrophenyl ester, N-hydroxysuccinimide ester, 1-hydroxybenzotriazole ester, or benzoxazoline-2-thione, and amine (1c) ), (Iii) carbodiimide method, ie, carboxylic acid (18) with amine (1c), dicyclohexylcarbodiimide, 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide (WSC), carbonyldiimidazole, etc. A method of condensation reaction in the presence of an activator, (d) other methods, for example A method in which rubonic acid (18) is converted into a carboxylic acid anhydride with a dehydrating agent such as acetic anhydride, and this is reacted with amine (1c). And a method of reacting an acid halide of carboxylic acid (18), that is, a method of reacting carboxylic acid halide with amine (1c).

  The mixed acid anhydride used in the mixed anhydride method (I) is obtained by a normal Schotten-Baumann reaction, and is usually reacted with an amine (1c) without isolation to give a general formula (1f) The compound of the present invention is produced.

  The Schotten-Baumann reaction is carried out in the presence of a basic compound.

  The basic compound used is a compound commonly used in the Schotten-Baumann reaction, for example, triethylamine, trimethylamine, pyridine, dimethylaniline, N-ethyldiisopropylamine, dimethylaminopyridine, N-methylmorpholine, 1,5-diazabicyclo [4]. .3.0] nonene-5 (DBN), 1,8-diazabicyclo [5.4.0] undecene-7 (DBU), 1,4-diazabicyclo "[2.2.2] octane (DABCO), etc. Organic bases, carbonates such as sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, metal hydroxides such as sodium hydroxide, potassium hydroxide, calcium hydroxide, potassium hydride, sodium hydride, potassium, sodium , Sodium amide, sodium methylate, sodium Inorganic base metal alcoholates such as ethylate and the like.

  The reaction is usually performed at about -20 to 100 ° C, preferably about 0 to 50 ° C, and the reaction time is about 5 minutes to 10 hours, preferably about 5 minutes to 2 hours.

  The reaction between the obtained mixed acid anhydride and amine (1c) is usually performed at about -20 to 150 ° C, preferably about 10 to 50 ° C, and the reaction time is about 5 minutes to 10 hours, preferably 5 About minutes to 5 hours. The mixed acid anhydride method is generally performed in a solvent.

  As the solvent to be used, any solvent commonly used in the mixed acid anhydride method can be used. Specifically, halogenated hydrocarbons such as chloroform, dichloromethane, dichloroethane, carbon tetrachloride, benzene, toluene, xylene Aromatic hydrocarbons such as diethyl ether, diisopropyl ether, tetrahydrofuran, dimethoxyethane, and the like, esters such as methyl acetate, ethyl acetate, isopropyl acetate, N, N-dimethylacetamide, N, N-dimethyl Examples include aprotic polar solvents such as formamide, dimethyl sulfoxide, hexamethylphosphoric triamide, and mixed solvents thereof.

  Examples of the alkylhalocarboxylic acid used in the mixed acid anhydride method include methyl chloroformate, methyl bromoformate, ethyl chloroformate, ethyl bromoformate, and isobutyl chloroformate. The proportions of carboxylic acid (18), alkylhalocarboxylic acid and amine (1c) used in the process are usually equimolar, but alkylhalocarboxylic acid and carboxylic acid (18) with respect to amine (1c). Can be used within a range of about equimolar to about 1.5 times molar amount.

  The method (c) in which the condensation reaction is carried out in the presence of the activator is carried out in a suitable solvent in the presence or absence of a basic compound.

  As the solvent and the basic compound used here, any of the solvents used in the method of reacting the amine (1c) with the carboxylic acid halide of the following other method (d) can be used.

  The activator is used in an amount of at least equimolar amount, preferably equimolar to 5-fold molar amount relative to compound (1c). When WSC is used as the activator, the reaction proceeds advantageously when 1-hydroxybenzotriazole is added to the reaction system.

  The reaction is usually performed at about -20 to 180 ° C, preferably about 0 to 150 ° C, and the reaction is generally completed in about 5 minutes to 90 hours.

  Of the other methods (d), when a method of reacting a carboxylic acid halide with an amine (1c) is employed, the reaction is carried out in a suitable solvent in the presence of a basic compound.

  As the basic compound used, known compounds can be widely used. For example, any of the basic compounds used in the Schotten-Baumann reaction can be used.

  Examples of the solvent used include alcohols such as methanol, ethanol, isopropanol, propanol, butanol, 3-methoxy-1-butanol, ethyl cellosolve, methyl cellosolve, in addition to the solvent used in the mixed acid anhydride method. Acetonitrile, pyridine, acetone, water and the like can be mentioned.

  The proportion of amine (1c) and carboxylic acid halide used is not particularly limited and may be appropriately selected within a wide range. Usually, the latter is at least about equimolar, preferably equimolar to 5 times the former. It is better to use about molar amount.

  The reaction is usually carried out at about -20 to 180 ° C, preferably about 0 to 150 ° C, and the reaction is generally completed in about 5 minutes to 50 hours.

  Further, the amide bond forming reaction is carried out by converting carboxylic acid (18) and amine (1c) to diphenyl phosphinic chloride, phenyl-N-phenyl phosphoramido chloride, diethyl chlorophosphate, diethyl cyanophosphate, diphenyl phosphate azide, It can also be carried out by a method of reacting in the presence of a condensing agent of a phosphorus compound such as bis (2-oxo-3-oxazolidinyl) phosphinic chloride.

  The reaction is usually performed at about −20 to 150 ° C., preferably about 0 to 100 ° C. in the presence of a solvent and a basic compound used in the method of reacting the carboxylic acid halide with amine (1c). In general, the reaction is completed in about 5 minutes to 30 hours. The condensing agent and the carboxylic acid (18) may be used in an amount of at least about equimolar amount, preferably about equimolar to 2-fold molar amount with respect to amine (1c).

  The reaction between the compound (1c) and the compound (19) can be carried out under the same reaction conditions as in the reaction between the compound (15) and the compound (16) or (17) in the reaction process formula-9.

[Wherein, R ^1A , X, n, m, W, R ^7a , R ⁹ , R ¹⁰ and o are the same as above. R ^6b represents a C 1-6 alkoxycarbonyl group. The dotted line on the piperidine ring indicates that it may be a double bond. When the dotted line is a double bond, the group R ^6b , COOH group or group —CONR ⁹ R ¹⁰ is substituted. ]
Compound (21) is produced by hydrolyzing compound (20).

  The hydrolysis reaction is performed in a suitable solvent or without a solvent in the presence of an acid or a basic compound.

  Examples of the solvent used include water, lower alcohols such as methanol, ethanol, isopropanol and tert-butanol, ketones such as acetone and methyl ethyl ketone, ethers such as diethyl ether, dioxane, tetrahydrofuran, monoglyme and diglyme, acetic acid, Fatty acids such as formic acid, esters such as methyl acetate and ethyl acetate, halogenated hydrocarbons such as chloroform, dichloromethane, dichloroethane and carbon tetrachloride, dimethyl sulfoxide, N, N-dimethylformamide, hexamethylphosphoric triamide or a mixture thereof A solvent etc. can be mentioned.

  Examples of the acid include mineral acids such as hydrochloric acid, sulfuric acid, and hydrobromic acid, and organic acids such as sulfonic acid such as formic acid, acetic acid, trifluoroacetic acid, and P-toluenesulfonic acid.

  Examples of the basic compound include carbonates such as sodium carbonate, potassium carbonate, sodium hydrogen carbonate and potassium hydrogen carbonate, metal hydroxides such as sodium hydroxide, potassium hydroxide, calcium hydroxide and lithium hydroxide. be able to.

  The acid or basic compound is used in an amount of at least equimolar, preferably equimolar to 10-fold molar to the compound (20), but may be used in a large excess as a reaction solvent.

  The reaction proceeds normally at about 0 to 200 ° C., preferably about 0 to 150 ° C., and is generally completed in about 10 minutes to 30 hours.

  In order to complete the reaction after the hydrolysis treatment, the reaction may be carried out in an appropriate solvent in the presence of a basic compound, usually at 0 to 100 ° C., preferably at room temperature to about 70 ° C. for about 1 to 30 minutes. Good. As a solvent and a basic compound used here, among the reaction of the compound (1c) and the compound (18) in the above reaction formula-10, a method of reacting the carboxylic acid halide of the method (d) with the amine (1c). Any of the solvents and basic compounds used in the above can be used.

  The reaction between compound (21) and compound (22) is carried out under the same reaction conditions as in the reaction between compound (1c) and compound (18) in the above Reaction Scheme-10. However, although the reaction formula-10 converted the use amount of the carboxylic acid (18) with respect to the amine (1c) in the reaction, the reaction used the amine (22) with respect to the carboxylic acid (18). Convert the amount used.

[Wherein, R ^1A , n, X, m, W, o, X ² , R ⁴ and R ⁵ are the same as described above. ]
The reaction between compound (1i) and compound (23) is carried out under the same reaction conditions as in the reaction between compound (1c) and compound (17) in the above Reaction Scheme-10.

[Wherein, R ^1A , n, R ¹⁸ , X, m, W, o, R ⁴ and X ² are the same as defined above.

R ^6aa represents a C ^1-6 alkoxycarbonyl group.

R ^6bb is a C1-6 alkyl group; a phenyl group (on the phenyl ring, a C1-4 alkylenedioxy group, a cyano group, a nitro group, an amino group that may have a C1-6 alkyl group as a substituent, a substituted group) An amino-substituted sulfonyl group that may have a C1-6 alkyl group as a group, a C1-6 alkoxycarbonyl group, a C1-6 alkylthio group, a phenoxy group, a phenyl C1-6 alkoxy group, a pyrrolidinyl group [on the pyrrolidine ring, at least 1 oxo group may be substituted], imidazolyl group, isoxazolyl group, oxazolyl group, phenyl C1-6 alkyl group, phenyl group, amino C1-6 which may have C1-6 alkyl group as a substituent Alkyl group, pyrrolidinyl C1-6 alkoxy group, halogen atom, halogen-substituted or unsubstituted C1- 6 alkyl groups and at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted); phenyl C1-6 alkoxycarbonyl groups (on the phenyl ring, At least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted); benzofuryl C1 6 alkyl group (on the benzofuran ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group as a substituent) Species may be substituted); benzofuryl C1-6 alkenyl group (on the benzothiazole ring, halogen atom, halogen At least one group selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted); a phenoxy C1-6 alkyl group ( On the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. A thiazolyl C1-6 alkyl group (on the thiazole ring, at least one phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted] may be substituted); phenyl C1-6a Kill group (on the phenyl ring, selected from the group consisting of a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. A group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group. At least one kind may be substituted); pyridyl C1-6 alkyl group [on the pyridine ring at least one phenyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 And at least one group selected from the group consisting of an alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) C1-6 alkoxycarbonyl group; benzothienyl group; benzothienyl C1-6 alkyl group (at least one halogen atom may be substituted on the benzothiophene ring); indolyl C1-6 alkyl group (On the indole ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. 4H-1,3-benzodioxinyl group (at least one halogen atom may be substituted on the 4H-1,3-benzodioxin ring); naphthyl group; quinolyl group; Benzothiazolyl group (at least one C1-6 alkyl group may be substituted on the benzothiazole ring); 2,3-dihydro-1H- Ndenyl group (at least one oxo group may be substituted on the 2,3-dihydro-1H-indane ring); 9H-fluorenyl group or phenyl C2-6 alkenyl group (on the phenyl ring, And a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted).

R ^6c is a benzoyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C 1-6 alkyl group and a halogen-substituted or unsubstituted C 1-6 alkoxy group) Species may be substituted).

R ^6d represents a hydrogen atom, a phenyl group (on the phenyl ring, a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C 1-6 alkyl group, and a halogen-substituted or unsubstituted C 1-6 alkoxy At least one group selected from the group consisting of groups may be substituted], a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one group selected from the group may be substituted); a benzofuryl C1-6 alkyl group (on the benzofuran ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or At least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted; a benzofuryl group (the benzofuran); On the top, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) A phenoxy C1-6 alkyl group (on the phenyl ring, at least a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; 1 type may be substituted); thiazolyl C1-6 alkyl group (on thiazole ring, at least one phenyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl) And at least one group selected from the group consisting of a group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] A thiazolyl group (on the thiazole ring, at least one phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1- At least one group selected from the group consisting of 6 alkoxy groups may be substituted], a phenyl C1-6 alkyl group (on the phenyl ring, a phenyl group [on the phenyl ring] May be substituted with at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group], At least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group A species may be substituted); a pyridyl C1-6 alkyl group [on the pyridine ring, at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group; And at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted]; a benzothienyl C1-6 alkyl group (benzo At least one halogen atom may be substituted on the thiophene ring); indolyl C1-6 alkyl group (on the indole ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen) At least one group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted); a pyridyl group [on the pyridine ring At least one phenyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; A species may be substituted)]; a benzothienyl group (on the benzothiophene ring may be substituted with at least one halogen atom) or an indolyl group (on the indole ring) May be substituted with at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group). Show.

R ^6e represents a phenyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C 1-6 alkyl group, and a halogen-substituted or unsubstituted C 1-6 alkoxy group; Species may be substituted).

The total carbon number of the group —CHR ¹⁸ R ^6d in the general formula (1o) shall not exceed 6. ]
The reaction leading compound (1k) to compound (1l) is carried out under the same reaction conditions as the reaction leading compound (20) to the compound (21) in the above Reaction Scheme-11.

  The reaction between the compound (1l) and the compound (24) is performed under the same reaction conditions as the reaction between the compound (1c) and the compound (17) in the above Reaction Scheme-10.

    The reaction between compound (1l) and compound (25) is carried out under the same reaction conditions as in the reaction between compound (1c) and compound (18) in the above Reaction Scheme-10.

    The reaction between the compound (1l) and the compound (26) is performed under the same reaction conditions as the reaction between the compound (1c) and the compound (16) in the above Reaction Scheme-10.

    The reaction between compound (1l) and compound (27) is carried out under the same reaction conditions as in the reaction between compound (1c) and compound (19) in the above Reaction Scheme-10.

[Wherein, R ^1A , n, X, m, W, o and R ⁴ are the same as above. R ^6f represents a C 1-6 alkyl group or a phenyl C 1-6 alkyl group (on the phenyl ring, from a halogen atom, a halogen-substituted or unsubstituted C 1-6 alkyl group, and a halogen-substituted or unsubstituted C 1-6 alkoxy group. And at least one group selected from the group consisting of may be substituted). ]
The reaction of compound (1q) and compound (26) is carried out in a suitable solvent in the presence of a condensing agent.

  As a solvent used here, it is used by the method of making amine (1c) react with the carboxylic acid halide of the method (d) among reaction of the compound (1c) in the said Reaction formula-10, and a compound (18). Any solvent can be used.

  Examples of the condensing agent include N, N′-carbonyldiimidazole. The compound (26) and the condensing agent are used in an amount of at least 1 mol, preferably about 1 to 2 mol, relative to 1 mol of the compound (1q). The reaction is usually completed at about 0 to 150 ° C., preferably about 0 to 100 ° C. in about 1 to 30 hours.

[Wherein, R ^1A , n, X, m, W, o, R ⁹ and R ¹⁰ are the same as defined above. ]
The reaction between the compound (27) and the compound (28) is carried out under the same reaction conditions as in the reaction between the compound (1c) and the compound (16) in the above Reaction Scheme-10.

[Wherein, R ^1A , n, X, m, W, o, R ^7a and R ^10a are the same as above. Two Ws in the general formulas (1t) to (1v) may be the same or different. R ^9f represents a C 1-6 alkoxycarbonyl group. The dotted line on the piperidine ring indicates that it may be a double bond. When the dotted line is a double bond, the group-(W) oNR ^9f R ^10a , group-(W) oNHR ^10a or group-(W) oNR ^10a (COOR ^9g ) is substituted. R ^9g represents a C1-6 alkyl group or a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom as a substituent, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of alkoxy groups may be substituted). ]
The reaction for converting the compound (1t) to the compound (1u) is performed under the same reaction conditions as the reaction for converting the compound (20) in the reaction formula-11 to the compound (21).

  The reaction between compound (1u) and compound (29) is carried out under the same reaction conditions as in the reaction between compound (1q) and compound (26) in the aforementioned Reaction Scheme-14.

  The starting material compound (14) of Reaction Scheme-9 and the starting material compound (20) of Reaction Scheme-11 are novel compounds. These compounds can be easily produced, for example, by using the corresponding starting materials and following the methods shown in the above reaction process formulas -1-3.

  The compound (final compound) represented by the general formula (1) of the present invention and the intermediate obtained in each of the above reaction process formulas include stereoisomers and optical isomers.

  Each target compound obtained in each reaction scheme shown above is prepared by cooling the reaction mixture, for example, cooling, separating the crude reaction product by an isolation operation such as filtration, concentration, extraction, etc., column chromatography, It can be isolated and purified from the reaction mixture by ordinary purification operations such as crystals.

  The compounds of the present invention include pharmaceutically acceptable salts. Examples of such salts include inorganic acid salts such as hydrochloride, hydrobromide, nitrate, sulfate, and phosphate, methanesulfonate, p-toluenesulfonate, acetate, citrate, and tartaric acid. Examples thereof include organic acid salts such as salts, maleates, fumarate, malates and lactates.

  Next, a medical preparation containing the compound of the present invention as an active ingredient will be described.

  The above-mentioned medical preparation is prepared by formulating the compound of the present invention in the form of a normal medical preparation, and is usually used as a filler, a bulking agent, a binder, a moistening agent, a disintegrant, a surfactant, and a lubricant. It is prepared using a diluent or excipient.

  Such a medical preparation can be selected from various forms depending on the purpose of treatment, and representative examples thereof include tablets, pills, powders, solutions, suspensions, emulsions, granules, capsules, suppositories. Agents, injections (solutions, suspensions, etc.) and the like.

  As the carrier used for molding into a tablet form, known ones can be widely used, for example, lactose, sucrose, sodium chloride, glucose, urea, starch, calcium carbonate, kaolin, crystalline cellulose and other excipients, Water, ethanol, propanol, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethylcellulose, shellac, methylcellulose, potassium phosphate, polyvinylpyrrolidone and other binders, dry starch, sodium alginate, agar powder, laminaran powder, hydrogen carbonate Sodium, calcium carbonate, polyoxyethylene sorbitan fatty acid esters, sodium lauryl sulfate, stearic acid monoglyceride, starch, lactose and other disintegrants, sucrose, stearin, cocoa butter, hydrogenated oil and other disintegration inhibitors, quaternary ammonium Group, absorption accelerators such as sodium lauryl sulfate, humectants such as glycerin and starch, adsorbents such as starch, lactose, kaolin, bentonite and colloidal silicic acid, purified talc, stearate, boric acid powder, polyethylene glycol, etc. Lubricants and the like.

  Furthermore, the tablet can be made into a tablet with an ordinary tablet skin, if necessary, such as a sugar coating, a gelatin-encapsulated tablet, an enteric-coated tablet, a film-coated tablet, a double tablet, or a multilayer tablet.

  As the carrier used for forming into a pill form, known ones can be widely used, for example, excipients such as glucose, lactose, starch, cocoa butter, hydrogenated vegetable oil, kaolin, talc, gum arabic powder, Examples thereof include binders such as tragacanth powder, gelatin and ethanol, and disintegrants such as laminaran and agar.

  As the carrier used for forming into a suppository form, known carriers can be widely used, and examples thereof include polyethylene glycol, cacao butter, higher alcohol, esters of higher alcohol, gelatin, semi-synthetic glyceride and the like.

  When prepared as injections, solutions, emulsions and suspensions are preferably sterilized and isotonic with blood. As the diluent used for forming these liquids, emulsions and suspensions, known ones that are widely used can be used, for example, water, ethanol, propylene glycol, ethoxy Isooxyallyl alcohol, polyoxyisostearyl alcohol, polyoxyethylene sorbetane fatty acid esters and the like. In this case, a sufficient amount of sodium chloride, glucose or glycerin to prepare an isotonic solution may be contained in the pharmaceutical preparation, and a normal solubilizer, buffer, soothing agent, etc. Further, if necessary, a coloring agent, a preservative, a fragrance, a flavoring agent, a sweetening agent, and other pharmaceuticals may be contained.

  The amount of the compound of the present invention contained in the medical preparation is not particularly limited and can be appropriately selected from a wide range. Usually, it is preferable to contain 1 to 70% by weight of the compound of the present invention in the medical preparation. .

  There is no restriction | limiting in particular as the administration method of the medical formulation which concerns on this invention, It administers by the method according to various formulation forms, a patient's age, sex, a disease state, and other conditions. For example, in the case of tablets, pills, solutions, suspensions, emulsions, granules and capsules, they are administered orally. In the case of injections, they are administered alone or mixed with normal fluids such as glucose and amino acids and administered intravenously, and further, if necessary, alone intramuscularly, intradermally, subcutaneously or intraperitoneally. Can be administered. In the case of a suppository, it is administered intrarectally.

  The dosage of the above-mentioned medical preparation may be appropriately selected according to the usage, patient age, sex, degree of disease, and other conditions, and is usually 0.01-100 mg / kg body weight per day, preferably 0.1 to 50 mg is administered once to several times.

  Since the dosage varies depending on various conditions, a dosage smaller than the above range may be sufficient, or a dosage exceeding the above range may be necessary.

  The compound of the present invention has a specific effect particularly against Mycobacterium tuberculosis (Mycobacterium tuberculosis, atypical Mycobacterium), such as mycobacteria. The compound of the present invention has an excellent effect against multidrug-resistant Mycobacterium tuberculosis. The compound of the present invention has an antibacterial action against anaerobic bacteria.

  The compound of the present invention not only exhibits the above-mentioned activity in vitro but also exhibits the above-mentioned activity even when administered orally.

  The compound of the present invention does not induce diarrhea as seen in known antibacterial agents having a broad spectrum against general bacteria such as Gram-positive bacteria and Gram-negative bacteria, and has side effects compared to existing drugs. Since it is small, it can be a medical preparation that can be taken for a long time.

  The compound of the present invention has high characteristics such as long distribution of drug efficacy, excellent safety, and the like, which can be well distributed to lung tissue which is the main infectious organ of mycobacterial infection. A therapeutic effect can be expected.

  The compound of the present invention exhibits a strong bactericidal power against intracellular parasitic bacteria such as human-derived macrophage parasitic tuberculosis bacteria as compared with existing anti-tuberculosis agents, and therefore, the relapse rate of tuberculosis is reduced, and thus short-term It can be expected to be used as the main axis of prophylactic drugs, which is possible because chemotherapy is possible and mixed infection of HIV and tuberculosis is a serious problem.

  Examples of preparations, test examples, reference examples and examples are given below.

Formulation Example 1
100 g of the compound of the present invention, 40 g of Avicel (trade name, manufactured by Asahi Kasei Co., Ltd.), 30 g of corn starch and 2 g of magnesium stearate were mixed and polished, and then tableted with a sugar coated R10 mm kine.

  The obtained tablets were coated with a film coating agent consisting of 10 g of TC-5 (trade name, manufactured by Shin-Etsu Chemical Co., Ltd., hydroxypropylmethylcellulose), 3 g of polyethylene glycol 6000, 40 g of castor oil, and an appropriate amount of ethanol. A film coating tablet having the above composition was produced.

Reference example 1
Preparation of 1- [4- (tetrahydropyran-2-yloxy) phenyl] -4- [N- (4-chlorophenyl) -N-methylamino] piperidine 4- [N- (4-chlorophenyl) -N-methylamino ] Piperidine (2.52 g, 11.22 mmol), 2- (4-bromophenoxy) tetrahydropyran (2.89 g, 11.22 mmol), palladium acetate (50 mg, 0.22 mmol), (S)-( -)-2,2-bis (diphenylphosphino) -1,1'-binaphthyl (BINAP) (212 mg, 0.34 mmol) and sodium tert-butoxy (1.51 g, 15.71 mmol) under nitrogen atmosphere The mixture was heated to reflux in toluene (30 ml) for 3 hours. Ethyl acetate and water were added to the reaction mixture, and the mixture was stirred and the precipitate was removed by celite filtration. The filtrate was extracted with ethyl acetate. The organic phase was washed with saturated brine, dried over magnesium sulfate, and filtered. The obtained filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (n-hexane / ethyl acetate = 20/1) to give 1- [4- (tetrahydropyran-2-yloxy) phenyl] as a pale yellow powder. -4- [N- (4-chlorophenyl) -N-methylamino] piperidine (1.33 g, yield 30%) was obtained.
¹ H-NMR (CDCl ₃ ) δ ppm:
1.50-2.04 (10H, m), 2.68-2.80 (2H, m), 2.78 (3H, s), 3.50-3.70 (4H, m), 3. 85-4.03 (1H, m), 5.31 (1H, t, J = 5.7 Hz), 6.72 (2H, d, J = 9.1 Hz), 6.90 (2H, d, J = 9.2 Hz), 6.98 (2H, d, J = 9.2 Hz), 7.17 (2H, d, J = 9.1 Hz).

Reference example 2
Preparation of 4- {4- [N- (4-chlorophenyl) -N-methylamino] piperidin-1-yl} phenol 1- [4- (Tetrahydropyran-2-yloxy) phenyl] -4- [N- ( 4-chlorophenyl) -N-methylamino] piperidine (1.33 g, 3.32 mmol) was suspended in ethanol (80 ml), pyridinium p-toluenesulfonate (0.25 g, 1 mmol) was added, 70 Stir at 8 ° C. for 8 hours. Ethanol was distilled off under reduced pressure, and methylene chloride and saturated aqueous sodium hydrogen carbonate solution were added to the residue and stirred. This was extracted with methylene chloride, dried over magnesium sulfate and filtered. The obtained filtrate was concentrated under reduced pressure, and methylene chloride and n-hexane were added to the residue and stirred, and the resulting precipitate was collected by filtration to give 4- {4- [N- (4-chlorophenyl)- N-methylamino] piperidin-1-yl} phenol (922.5 mg, 88% yield) was obtained.
¹ H-NMR (CDCl ₃ ) δ ppm:
1.79-2.04 (4H, m), 2.67-2.79 (2H, m), 2.79 (3H, s), 3.56-3.68 (2H, m), 4. 48 (1H, s), 6.69-6.80 (4H, m), 6.85-6.92 (2H, m), 7.14-7.21 (2H, m).

  The following compounds were produced in the same manner as in Reference Example 1 and Reference Example 2. In the following table, “Ph” means a phenyl group or a phenylene group.

Reference example 3
(4-Chlorophenyl)-(4-hydroxyphenyl) methanone O-methyloxime Ms: 261 (M ^<+> ).

Reference example 4
(4-Hydroxyphenyl)-(4-trifluoromethylphenyl) methanone O-methyloxime Ms: 295 (M ⁺ ).

Example 1
(R) -2-Methyl-6-nitro-2- {2- [4- (4-trifluoromethoxybenzyl) -piperazin-1-yl] benzothiazol-6-yloxymethyl} -2,3-dihydro Preparation of imidazo [2,1-b] oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole (51 mg, 0.23 mmol) ) And 6-hydroxy-2- [4- (4-trifluoromethoxybenzyl) -piperazin-1-yl] -benzothiazole (80 mg, 0.20 mmol) are dissolved in DMF (5 ml) and sodium hydride is dissolved. (10 mg, 0.25 mmol) was added and stirred at 60 ° C. for 1.5 hours. After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The combined organic layer was washed with water and saturated brine, and dried over sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane: ethyl acetate = 1: 3 → ethyl acetate), recrystallized from ethanol, and colorless powder crystals of (R) -2-methyl-6-nitro-2- { 2- [4- (4-trifluoromethoxybenzyl) -piperazin-1-yl] benzothiazol-6-yloxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole (40 mg, yield) 33%) was obtained.
Melting point: 205.6-207.4 ° C.

Example 2
(R) -2-Methyl-6-nitro-2- {2- [4- (4-trifluoromethoxyphenoxy) piperidin-1-yl} pyridin-5-oxy] methyl-2,3-dihydro-imidazo [ Preparation of 2,1-b] oxazole 5-hydroxy-2- {4- [4- (trifluoromethoxy) phenoxy] piperidin-1-yl} pyridine 0.67 g (1.9 mmol) and (R) 0.51 g (2.4 mmol) of 2-chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole was dissolved in 6.7 ml of DMF. To this was added 91 mg (2.3 mmol) of sodium hydride, and the mixture was heated and stirred at 50 to 55 ° C. for 1 hour. Water was added to the reaction solution and extracted with methylene chloride. The organic layer was washed with saturated brine, dried over magnesium sulfate, and filtered with suction. The resulting filtrate was concentrated under reduced pressure. The residue was separated and purified by silica gel column chromatography (methylene chloride / ethyl acetate = 10/0, 9/1, 8/2), and further crystallized with methylene chloride / diisopropyl ether / ethyl acetate to give (R ) -2-Methyl-6-nitro-2- {2- [4- (4-trifluoromethoxyphenoxy) piperidin-1-yl] pyridin-5-oxy] methyl-2,3-dihydro-imidazo [2, 0.30 g (29%) of 1-b] oxazole was obtained.
¹ H-NMR (CDCl ₃ ) δ ppm:
1.77 (3H, s), 1.80-1.94 (2H, m), 1.94-2.17 (2H, m), 3.21-3.44 (2H, m), 3. 67-3.89 (2H, m), 3.96-4.11 (2H, m), 4.19 (1H, d, J = 10.4 Hz), 4.36-4.59 (2H, m) ), 6.65 (1H, d, J = 9.2 Hz), 6.83-6.97 (2H, m), 7.02-7.20 (3H, m), 7.56 (1H, s) ), 7.87 (1H, d, J = 3.0 Hz).

  The following compounds were produced in the same manner as in Example 2 above. In the following table, “Ph” means a phenyl group or a phenylene group.

Example 3
(R) -2- (4- {4- [N- (4-Chlorophenyl) -N-methylamino] piperidin-1-yl} phenoxymethyl) -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole melting point: 173.7-175.1C.

Example 4
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b ] Oxazole
¹ H-NMR (CDCl ₃ ) δ ppm:
1.23-1.52 (2H, m), 1.52-1.66 (3H, m), 1.66-1.89 (3H, m), 2.43-2.70 (4H, m ), 3.50 (2H, d, J = 12.1 Hz), 3.91-4.09 (2H, m), 4.16 (1H, d, J = 10.1 Hz), 4.48 (1H , D, J = 10.2 Hz), 6.66-6.81 (2H, m), 6.81-6.95 (2H, m), 7.05-7.23 (4H, m), 7 .54 (1H, s)
Melting point: 210.9-212.4 ° C
[Α] _D = −9.0 ° (concentration: 1.0, CHCl ₃ ).

Example 5
(R) -2- {4- [4- (3,4-Dichlorobenzyl) piperidin-1-yl] phenoxymethyl} -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b ] Oxazole
¹ H-NMR (CDCl ₃ ) δ ppm:
1.24-1.52 (2H, m), 1.52-1.64 (4H, m), 1.64-1.73 (1H, m), 1.73-1.87 (4H, m) ), 2.38-2.68 (4H, m), 3.49 (2H, d, J = 12.1 Hz), 3.91-4.09 (2H, m), 4.16 (1H, d) , J = 10.2 Hz), 4.49 (1H, d, J = 10.2 Hz), 6.67-6.81 (2H, m), 6.81-6.92 (2H, m), 6 .94-7.07 (1H, m), 7.25 (1H, s), 7.35 (1H, d, J = 8.2 Hz), 7.55 (1H, s)
Melting point: 180.0-181.2 ° C
[Α] _D = −8.5 ° (concentration: 1.0, CHCl ₃ ).

Example 6
(R) -6-nitro-2- {4- [4- (4-trifluoromethoxybenzyloxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole Melting point: 140.4-141.7 ° C.

Example 7
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylbenzyloxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1 -B] Oxazole melting point: 172.3-172.9 [deg.] C.

Example 8
(R) -2-Methyl-6-nitro-2- (4- {4- [3- (4-trifluoromethylphenyl) -2-propenyl] piperazin-1-yl} phenoxymethyl) -2,3- Dihydroimidazo [2,1-b] oxazole melting point: 199.7-202 ° C.

Example 9
(R) -2-Methyl-6-nitro-2- (4- {4- [2- (4-trifluoromethoxyphenoxy) ethyl] piperazin-1-yl} phenoxymethyl) -2,3-dihydroimidazo [ 2,1-b] oxazole melting point: 194.8-195.6 ° C.

Example 10
(R) -2- (4- {4- [N- (4-Chlorophenyl) -N-ethylamino] piperidin-1-yl} phenoxymethyl) -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole melting point: 121.4-125 ° C.

Example 11
(R) -2- (4- {4- [N-ethyl-N- (4-trifluoromethoxyphenyl) amino] piperidin-1-yl} phenoxymethyl) -2-methyl-6-nitro-2,3 Dihydroimidazo [2,1-b] oxazole melting point: 122.5-122.8 ° C.

Example 12
(R) -2- (4- {4- [N-ethyl-N- (4-trifluoromethylphenyl) amino] piperidin-1-yl} phenoxymethyl) -2-methyl-6-nitro-2,3 Dihydroimidazo [2,1-b] oxazole melting point: 105-108.5 ° C.

Example 13
(R) -2- {4- [4- (5-Chlorobenzofuran-2-ylmethyl) piperazin-1-yl] phenoxymethyl} -2-methyl-6-nitro-2,3-dihydroimidazo [2,1 -B] Oxazole melting point: 210.6-211.6 ° C.

Example 14
(R) -2-Methyl-6-nitro-2- {2- [4- (4-trifluoromethoxybenzyl) piperazin-1-yl] benzothiazol-6-yloxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole melting point: 203.9-205.2 ° C.

Example 15
2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole melting point: 180.9-182.7 ° C.

Example 16
2- {4- [4- (3,4-Dichlorobenzyl) piperidin-1-yl] phenoxymethyl} -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole Melting point: 191.4-192.1 ° C.

Example 17
2- (4- {4- [N- (4-Chlorophenyl) -N-methylamino] piperidin-1-yl} phenoxymethyl) -2-methyl-6-nitro-2,3-dihydroimidazo [2,1 -B] Oxazole melting point: 137.6-141.5 ° C.

Example 18
(R) -2- (4- {4- [N- (4-Chlorophenyl) -N-methylamino] piperidin-1-yl} phenoxymethyl) -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole 4-toluenesulfonate melting point: 212.6-214.1 ° C.

Example 19
(R) -2- (4- {4- [N- (4-Chlorophenyl) -N-methylamino] piperidin-1-yl} phenoxymethyl) -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole methanesulfonate melting point: 171.2-172.8 ° C.

Example 20
(R) -2- (4- {4- [N- (4-Chlorophenyl) -N-methylamino] piperidin-1-yl} phenoxymethyl) -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole hydrochloride melting point: 170.0-173.7 ° C.

Example 21
2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylbenzyloxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] Oxazole melting point: 153.1-153.7 ° C.

Example 22
(R)-(4-Chlorophenyl) carbamic acid 1- [4- (2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazol-2-ylmethoxy) phenyl] piperidine-4- Ilmethyl ester melting point: 211.6-212.3 ° C. (decomposition).

Example 23
2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylbenzyloxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] Oxazole melting point: 138.7-139.5 ° C.

Example 1098
(R) -2-Methyl-2- {4- [N-methyl-N- (1-methylpiperidin-4-yl) amino] phenoxymethyl} -6-nitro-2,3-dihydroimidazo [2,1 -B] oxazole Example 1099
(R) -4- {1- [4- (2-Methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazol-2-ylmethoxy) phenyl] -3- (4-trifluoro Methoxyphenyl) ureido} piperidine-1-carboxylic acid (4-trifluoromethoxyphenyl) amide Example 1100
6-Nitro-2- {4- [4- (4-trifluoromethoxybenzyloxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole melting point: 140. 2-141.7 ° C.

Example 1101
(R) -2-Methyl-6-nitro-2- {4- [4- (tetrahydropyran-2-yloxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1 -B] Oxazole melting point: 217.6-218.6 ° C.

Example 1102
(R) -2-methyl-6-nitro-2- {4- [4- (hydroxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole melting point: 213.3-215.3 ° C.

Example 1103
2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethoxyphenoxy) piperidin-1-yl] benzyl} -2,3-dihydroimidazo [2,1-b] oxazole melting point: 184 .9-186.8 ° C.

Example 1104
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethoxyphenyl) carbamoyloxymethylpiperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2, 1-b] Oxazole melting point: 211.6-212.0 ° C. (decomposition).

Example 1105
(R) -2- {4- [4- (Biphenyl-4-yloxymethyl) piperidin-1-yl] phenoxymethyl} -2-methyl-6-nitro-2,3-dihydroimidazo [2,1- b] Oxazole melting point: 245 ° C (decomposition).

Example 1106
(R) -2- {1-benzyl-2- [4- (4-trifluoromethoxybenzyl) piperazin-1-yl] -1H-benzimidazol-5-yloxymethyl} -2-methyl-6-nitro- 2,3-dihydroimidazo [2,1-b] oxazole melting point: 101.3-104.0 ° C.

Example 1107
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-ylmethyl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b ] Oxazole melting point: 172.5-174.1 ° C.

Example 1108
2- {4- [4- (N-methyl-tert-butoxycarbonylamino) piperidin-1-ylmethyl] phenoxymethyl}
2-Methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole melting point: 138.5-141.9 [deg.] C.

Example 1109
(R) -2- [4 ′-(4-tert-butoxycarbonyl-1,4-diazepan-1-yl) biphenyl-4-yloxymethyl] -2-methyl-6-nitro-2,3-dihydro Imidazo [2,1-b] oxazole melting point: 213.8-215.7 ° C.

Example 1110
(R) -2- [4 ′-(4-tert-Butoxycarbonyl-1,4-diazepan-1-yl) biphenyl-4-yloxymethyl] -6-nitro-2,3-dihydroimidazo [2, 1-b] Oxazole melting point: 235.5-237.5 ° C.

Example 1111
(S) -2-methyl-2- (N-methyl-N- {4- [N-methyl-N- (4-trifluoromethylcinnamyl) amino] benzyl} aminomethyl) -6-nitro-2, 3-dihydroimidazo [2,1-b] oxazole melting point: 153.5-154.5 ° C.

Example 1112
(R) -2-Methyl-6-nitro-2- (4- {2-oxo-2- [4- (4-trifluoromethoxyphenoxy) piperidin-1-yl] ethylaminocarbonyl} phenoxymethyl) -2 , 3-Dihydroimidazo [2,1-b] oxazole melting point: 186.9-189.5 [deg.] C.

Example 1113
2-Methyl-6-nitro-2- {2- [4- (4-trifluoromethoxybenzyl) piperazin-1-yl] benzothiazol-6-yloxymethyl} -2,3-dihydroimidazo [2,1 -B] Oxazole melting point: 172.6-174.6 ° C.

Example 1114
2- {4- [4- (4-Chlorophenoxymethyl) piperidin-1-yl] phenoxymethyl} -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole Melting point: 190 0.0-190.4 ° C.

Example 1115
2- {4- [4- (4-chlorophenoxymethyl) piperidin-1-yl] phenoxymethyl} -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole melting point: 191.2-192 .5 ° C.

Example 1116
6-Nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole Melting point: 132.7- 135.0 ° C.

Example 1117
2-methyl-6-nitro-2- (4- (4- (4-trifluoromethoxycinnamyl) piperazin-1-yl) phenoxymethyl) -2,3-dihydroimidazo [2,1-b] oxazole melting point : 181.1-182.2 ° C.

Example 1463
(R) -2- {4- [4- (4-Chlorophenyl) oxazol-2-yl] phenoxymethyl} -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole Preparation (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 1.73 g (7.9 mmol), 4- [4- (4-chlorophenyl) ) Oxazol-2-yl] phenol 1.80 g (6.6 mmol) and potassium phosphate 0.42 g (2.0 mmol) were suspended in ethanol 15 ml, heated to reflux for 3 hours under an argon atmosphere and stirred. The reaction mixture was concentrated, dichloromethane was added to the residue, and the insoluble material was filtered off. The filtrate was concentrated and the residue was dissolved in 20 ml DMF. Under ice cooling, 0.29 g (7.3 mmol) of 60% sodium hydride was added and stirred for 6 hours. The solvent was distilled off under reduced pressure, and 100 ml of acetone and 10 ml of silica gel were added to the residue and concentrated. The residue was purified by silica gel column chromatography (dichloromethane: methanol = 50: 1 to 30: 1), and crystallized from a dichloromethane-ethanol mixed solvent. Recrystallization from an acetone-water mixed solvent gave (R) -2- {4- [4- (4-chlorophenyl) oxazol-2-yl] phenoxymethyl} -2-methyl-6-nitro- as a light brown powder. 1.15 g (38% yield) of 2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 248.8-251.5 ° C.

Example 1464
6-((R) -2-Methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazol-2-ylmethoxy) -2- [4- (4-trifluoromethoxybenzyl) piperidine- Preparation of 1-yl] quinoline (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 0.65 g and 6-hydroxy-2- [4- (4-Trifluoromethoxybenzyl) piperidin-1-yl] quinoline (1.00 g) and potassium phosphate (0.16 g) were suspended in ethanol (10 ml), and the mixture was heated to reflux for 4 hours under an argon atmosphere and stirred. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (n-hexane: ethyl acetate = 1: 3 → ethyl acetate) and concentrated. The obtained residue was dissolved in DMF (10 ml), 99 mg of sodium hydride was added, and the mixture was stirred at room temperature for 1 hour. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The combined organic layers were washed with water and saturated brine, and then dried over sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane: ethyl acetate = 1: 1 → 1: 3) and recrystallized from ethanol to give 6-((R) -2-methyl-6 as pale yellow powder crystals. -Nitro-2,3-dihydroimidazo [2,1-b] oxazol-2-ylmethoxy) -2- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] quinoline 0.57 g (36%) Got.
Melting point: 184.9-185.9 ° C.

Example 1465
6-((R) -2-Methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazol-2-ylmethoxy) -2- [4- (4-trifluoromethoxybenzylidene) piperidine- Preparation of 1-yl] quinoline (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 0.66 g and 6-hydroxy-2- [4- (4-trifluoromethoxybenzylidene) -piperidin-1-yl] quinoline (0.94 g) and potassium phosphate (0.15 g) were suspended in ethanol (10 ml), and the mixture was heated to reflux for 6 hours under an argon atmosphere and stirred. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (n-hexane: ethyl acetate = 1: 3 → ethyl acetate) and concentrated. The obtained residue was dissolved in DMF (10 ml), 99 mg of sodium hydride was added, and the mixture was stirred at room temperature for 3 hours. Ethyl acetate was added to the reaction mixture, and the mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: methanol = 50: 1) and recrystallized from ethanol to give yellow powder crystals of 6-((R) -2-methyl-6-nitro-2,3-dihydro 1.37 g (51%) of imidazo [2,1-b] oxazol-2-ylmethoxy) -2- [4- (4-trifluoromethoxybenzylidene) piperidin-1-yl] quinoline was obtained.
Melting point: 193.9-195.9 ° C.

Example 1466
(R) -2-Methyl-6-nitro-2- {6- [4- (4-trifluoromethoxyphenoxy) piperidin-1-yl] naphthalen-2-yloxymethyl} -2,3-dihydroimidazo [ Preparation of 2,1-b] oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 2.12 g and 6- [4- (4 -Trifluoromethoxyphenoxy) piperidin-1-yl] naphthalen-2-ol (3.02 g) and potassium phosphate (0.48 g) were suspended in ethanol (30 ml), and the mixture was heated to reflux for 6 hours in a nitrogen atmosphere and stirred. Water was added to the reaction mixture, and the mixture was extracted with dichloromethane. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated. The residue was purified by silica gel column chromatography (n-hexane: ethyl acetate = 1: 3 → ethyl acetate) and then concentrated to obtain 2.73 g of a yellow powder. This was dissolved in DMF (27 ml), 0.21 g of sodium hydride was added, and the mixture was stirred at room temperature for 2.5 hours. Saturated brine was added to the reaction mixture, and the mixture was extracted with dichloromethane. The combined organic layers were washed with water and saturated brine, and then dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 4: 1). Recrystallization from a dichloromethane-ethyl acetate-diisopropyl ether mixed solvent gave pale yellow powdered crystals of (R) -2-methyl-6-nitro-2- {6- [4- (4-trifluoromethoxyphenoxy) piperidine-1 -Il] naphthalen-2-yloxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole 1.05 g (yield 24%) was obtained.
Melting point: 204.8-207.9 ° C.

Example 1467
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethoxybenzyloxy) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1- b] Preparation of oxazole 0.305 g of 4- [4- (4-trifluoromethoxybenzyloxy) piperidin-1-yl] phenol was dissolved in DMF (5 ml), 10 mg of sodium hydride was added, and 70-80 ° C was added. For 20 minutes. Under cooling with ice, 0.252 g of (R) -2-chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole was added, and the mixture was stirred at 70 to 80 ° C. for 20 minutes. After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The combined organic layers were washed with water and saturated brine, and then dried over sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane: ethyl acetate = 1: 3 → ethyl acetate). Recrystallization from a dichloromethane-ethyl acetate mixed solvent gave colorless powder crystals of (R) -2-methyl-6-nitro-2- {4- [4- (4-trifluoromethoxybenzyloxy) piperidin-1-yl]. Phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole 88 mg (26.7%) was obtained.
Melting point: 214.3-217.7 ° C.

Example 1468
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylbenzyloxy) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1- b] Production of oxazole 0.217 g of 4- [4- (4-trifluoromethylbenzyloxy) piperidin-1-yl] phenol was dissolved in DMF (5 ml), 27 mg of sodium hydride was added, and 70-80 ° C was added. For 20 minutes. Under ice cooling, 0.188 g of (R) -2-chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole was added, and the mixture was stirred at 70 to 80 ° C. for 20 minutes. After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The combined organic layers were washed with water and saturated brine, and then dried over sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane: ethyl acetate = 1: 3 → ethyl acetate). Recrystallization from a dichloromethane-ethyl acetate mixed solvent gave (R) -2-methyl-6-nitro-2- {4- [4- (4-trifluoromethylbenzyloxy) piperidin-1-yl] as a pale yellow powder. Phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole 88 mg (26.7%) was obtained.
Melting point: 217.4-219.7 [deg.] C.

Example 1469
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b Preparation of oxazole 8.41 g of 4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenol was dissolved in DMF (84 ml), 1.05 g of sodium hydride was added, and 70-80 ° C. For 20 minutes. Under ice-cooling, 7.29 g of (R) -2-chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole was added, and the mixture was stirred at 70 to 80 ° C. for 20 minutes. After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The combined organic layers were washed with water and saturated brine, and then dried over sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 9: 1). Recrystallization from a dichloromethane-ethyl acetate mixed solvent gave (R) -2-methyl-6-nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenoxy as a pale yellow powder. 4.65 g (36.5%) of methyl} -2,3-dihydroimidazo [2,1-b] oxazole were obtained.
¹ H-NMR (CDCl ₃ ) δ ppm:
1.23-1.52 (2H, m), 1.52-1.66 (3H, m), 1.66-1.89 (3H, m), 2.43-2.70 (4H, m ), 3.50 (2H, d, J = 12.1 Hz), 3.91-4.09 (2H, m), 4.16 (1H, d, J = 10.1 Hz), 4.48 (1H , D, J = 10.2 Hz), 6.66-6.81 (2H, m), 6.81-6.95 (2H, m), 7.05-7.23 (4H, m), 7 .54 (1H, s)
Melting point: 210.9-212.4 ° C
^{[Α] D = -9.0 ° (} c = 1.0, CHCl 3).

Example 1470
(R) -2- {4- [4- (4-Chlorobenzyl) piperidin-1-yl] phenoxymethyl} -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole Preparation of 4- [4- (4-chlorobenzyl) piperidin-1-yl] phenol (1.036 g) was dissolved in DMF (5 ml), sodium hydride (151 mg) was added, and the mixture was stirred at 70-80 ° C. for 20 min. Under ice-cooling, 1.04 g of (R) -2-chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole was added, and the mixture was stirred at 70 to 80 ° C. for 20 minutes. After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The combined organic layers were washed with water and saturated brine, and then dried over sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane: ethyl acetate = 1: 3 → ethyl acetate). Recrystallization from a dichloromethane-ethyl acetate mixed solvent gave (R) -2- {4- [4- (4-chlorobenzyl) piperidin-1-yl] phenoxymethyl} -2-methyl-6- 6 as light yellow powder crystals. 0.286 g (17.3%) of nitro-2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 207.1-211.2 ° C.

Example 1471
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethoxycinnamyloxy) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1 -B] Preparation of oxazole 2.21 g of 4- [4- (4-trifluoromethoxycinnamyloxy) piperidin-1-yl] phenol was dissolved in DMF (22 ml), 0.247 g of sodium hydride was added, It stirred at 70-80 degreeC for 20 minutes. Under ice cooling, 1.71 g of (R) -2-chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole was added, and the mixture was stirred at 70 to 80 ° C. for 20 minutes. After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The combined organic layers were washed with water and saturated brine, and then dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 9: 1). Recrystallization from a dichloromethane-ethyl acetate mixed solvent gave pale yellow powdered crystals of (R) -2-methyl-6-nitro-2- {4- [4- (4-trifluoromethoxycinnamyloxy) piperidine-1- Yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole 0.70 g (21.7%) was obtained.
Melting point: 213.7-217.4 ° C.

Example 1472
(R) -6-nitro-2- {4- [4- (4-trifluoromethoxybenzyloxy) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole Preparation 4.60 g of 4- [4- (4-trifluoromethoxybenzyloxy) piperidin-1-yl] phenol is dissolved in DMF (46 ml), 0.55 g of sodium hydride is added, Stir for minutes. Under ice-cooling, 3.57 g of (R) -2-chloro-1-oxiranylmethyl-4-nitro-1H-imidazole was added, and the mixture was stirred at 70 to 80 ° C. for 20 minutes. After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The combined organic layers were washed with water and saturated brine, and then dried over sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 9: 1 → 6: 4). Recrystallization from a dichloromethane-ethyl acetate mixed solvent gave (R) -6-nitro-2- {4- [4- (4-trifluoromethoxybenzyloxy) piperidin-1-yl] phenoxymethyl} as pale yellow powder crystals. 0.99 g (14.8%) of -2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 188.3-189.4 [deg.] C.

Example 1473
(R) -2-Methyl-6-nitro-2- [4- {4- [2- (4-trifluoromethoxyphenyl) ethyl] piperidin-1-yl} phenoxymethyl] -2,3-dihydroimidazo [ Preparation of 2,1-b] oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 1.01 g and 4- {4- [2 1.36 g of-(4-trifluoromethoxyphenyl) ethyl] piperidin-1-yl} phenol was dissolved in DMF (14 ml), 0.18 g of sodium hydride was added, and the mixture was stirred at 50 ° C for 1 hour. After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The combined organic layers were washed with water and saturated brine, and then dried over sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 9: 1 → 8: 2). Recrystallization from a mixed solvent of dichloromethane-ethyl acetate-diisopropyl ether gave (R) -2-methyl-6-nitro-2- [4- {4- [2- (4-trifluoromethoxyphenyl)] as pale yellow powder crystals. Ethyl] piperidin-1-yl} phenoxymethyl] -2,3-dihydroimidazo [2,1-b] oxazole 0.70 g (34.4%) was obtained.
Melting point: 239.4-241.3 [deg.] C.

Example 1474
(R) -2-Methyl-6-nitro-2- {6- [4- (4-trifluoromethoxyphenoxy) piperidin-1-yl] pyridin-3-yloxymethyl} -2,3-dihydroimidazo [ Preparation of 2,1-b] oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 0.51 g and 3-hydroxy-6- [ 0.67 g of 4- (4-trifluoromethoxyphenoxy) piperidin-1-yl] pyridine was dissolved in DMF (6.7 ml), 91 mg of sodium hydride was added, and the mixture was stirred at 50 ° C. for 1 hour. After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The combined organic layers were washed with water and saturated brine, and then dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 9: 1 → 8: 2). Recrystallization from a dichloromethane-ethyl acetate-diisopropyl ether mixed solvent gave pale yellow powdered crystals of (R) -2-methyl-6-nitro-2- {6- [4- (4-trifluoromethoxyphenoxy) piperidine-1 -Yl] pyridin-3-yloxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole 296 mg (29.1%) was obtained.
Melting point: 185.9-186.7 ° C.

Example 1475
Preparation of (R) -6-nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole 0.72 g of (R) -2-chloro-1-oxiranylmethyl-4-nitro-1H-imidazole and 1.00 g of 4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenol , Dissolved in DMF (10 ml), 0.14 g of sodium hydride was added, and the mixture was stirred at 50 ° C. for 1 hour. After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The combined organic layers were washed with water and saturated brine, and then dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 9: 1 → 7: 3). Recrystallization from a dichloromethane-ethyl acetate-diisopropyl ether mixed solvent gave (R) -6-nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenoxy as pale yellow powder crystals. 0.20 g (13.7%) of methyl} -2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 160.5-164.0 ° C.

Example 1476
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethoxyphenyl) -1,4-diazepan-1-yl] phenoxymethyl} -2,3-dihydroimidazo [ Preparation of 2,1-b] oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 2.21 g and 4- [4- (4 -Trifluoromethoxyphenyl) -1,4-diazepan-1-yl] phenol 2.86 g was dissolved in DMF (29 ml), 0.39 g of sodium hydride was added, and the mixture was stirred at 50 ° C. for 1 hour. After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with dichloromethane. The combined organic layers were washed with water and saturated brine and concentrated. The residue was purified by silica gel column chromatography (n-hexane: ethyl acetate = 1: 3 → ethyl acetate). (R) -2-methyl-6-nitro-2- {4- [4- (4-trifluoromethoxyphenyl) -1,4-diazepan-1-yl] phenoxy recrystallized from isopropyl alcohol 720 mg (16.6%) of methyl} -2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 134.0-137.9 ° C.

Example 1477
(R) -2-methyl-2- [4- {4- [N-methyl-N- (2-fluoro-4-trifluoromethylbenzyl) amino] piperidin-1-yl} phenoxymethyl] -6-nitro Preparation of 2,3-dihydroimidazo [2,1-b] oxazole (R) -2-Methyl-2- [4- {4- [N-methyl-N-tert-butoxycarbonylamino] piperidine-1- [Il} phenoxymethyl] -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole 0.80 g was dissolved in 2 ml of trifluoroacetic acid and 2 ml of dichloromethane, and the mixture was stirred at room temperature for 15 hours. The reaction solution was concentrated under reduced pressure, and 2 ml each of dichloromethane and triethylamine were added. After stirring at room temperature for 5 minutes, the mixture was concentrated under reduced pressure. The residue was dissolved in 8 ml of dichloroethane. Under ice cooling, 0.63 g of 2-fluoro-4-trifluoromethylbenzaldehyde and 0.70 g of sodium triacetoxyborohydride were added, and the mixture was warmed to room temperature and stirred for 24 hours. An aqueous potassium carbonate solution and dichloromethane were added to the reaction mixture, and the mixture was stirred and extracted with dichloromethane. The organic layer was dried over magnesium sulfate and then filtered. The resulting filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: methanol = 9: 1). Crystallization from ethyl acetate gave (R) -2-methyl-2- [4- {4- [N-methyl-N- (2-fluoro-4-trifluoromethylbenzyl) amino] piperidine as a pale yellow powder. -1-yl} phenoxymethyl] -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole (0.48 g, yield 51.8%) was obtained.
Melting point: 197.5-199.2 ° C.

Example 1478
(R) -2-methyl-2- [4- {4- [N-methyl-N- (2-trifluoromethylbenzyl) amino] piperidin-1-yl} phenoxymethyl] -6-nitro-2,3 Preparation of dihydroimidazo [2,1-b] oxazole (R) -2-Methyl-2- [4- {4- [N-methyl-N-tert-butoxycarbonylamino] piperidin-1-yl} phenoxymethyl ] 0.80 g of 6-nitro-2,3-dihydroimidazo [2,1-b] oxazole was dissolved in 2 ml of trifluoroacetic acid and 2 ml of dichloromethane, and stirred at room temperature for 15 hours. The reaction solution was concentrated under reduced pressure, and 2 ml each of dichloromethane and triethylamine were added. After stirring at room temperature for 5 minutes, the mixture was concentrated under reduced pressure. The residue was dissolved in 8 ml of dichloroethane, and 0.57 g of 2-trifluoromethylbenzaldehyde and 0.70 g of sodium triacetoxyborohydride were added under ice cooling, and the mixture was warmed to room temperature and stirred for 24 hours. An aqueous potassium carbonate solution and dichloromethane were added to the reaction mixture, and the mixture was stirred and extracted with dichloromethane. The organic layer was dried over magnesium sulfate and then filtered. The resulting filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: methanol = 9: 1). Crystallization from ethyl acetate gave (R) -2-methyl-2- [4- {4- [N-methyl-N- (2-fluoro-4-trifluoromethylbenzyl) amino] piperidine as a pale yellow powder. -1-yl} phenoxymethyl] -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole (0.47 g, yield 52.4%) was obtained.
Melting point: 189.6-190.2 [deg.] C.

Example 1479
(R) -2-methyl-2- [4- {4- [N-methyl-N- (3,5-bistrifluoromethylbenzyl) amino] piperidin-1-yl} phenoxymethyl] -6-nitro-2 , 3-Dihydroimidazo [2,1-b] oxazole (R) -2-Methyl-2- [4- {4- [N-methyl-N-tert-butoxycarbonylamino] piperidin-1-yl} 0.80 g of phenoxymethyl] -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole was dissolved in 2 ml of trifluoroacetic acid and 2 ml of dichloromethane, and stirred at room temperature for 15 hours. The reaction solution was concentrated under reduced pressure, and 2 ml each of dichloromethane and triethylamine were added. After stirring at room temperature for 5 minutes, the mixture was concentrated under reduced pressure. The residue was dissolved in 8 ml of dichloroethane, 0.79 g of 3,5-bistrifluoromethylbenzaldehyde and 0.70 g of sodium triacetoxyborohydride were added under ice cooling, and the mixture was warmed to room temperature and stirred for 19 hours. An aqueous potassium carbonate solution and dichloromethane were added to the reaction mixture, and the mixture was stirred and extracted with dichloromethane. The organic layer was dried over magnesium sulfate and then filtered. The resulting filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: methanol = 9: 1). Crystallization from ethyl acetate gave (R) -2-methyl-2- [4- {4- [N-methyl-N- (3,5-bistrifluoromethylbenzyl) amino] piperidine-1 as a pale yellow powder. -Il} phenoxymethyl] -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole 0.55 g (yield 54.9%) was obtained.
Melting point: 193.8-195.3 ° C.

Example 1480
(R) -2-Methyl-6-nitro-2- {4- [4- (3-trifluoromethoxybenzyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b Preparation of oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 1.21 g and 4- [4- (3-trifluoromethoxybenzyl) ) Piperidin-1-yl] phenol 1.56 g was dissolved in DMF (16 ml), 0.21 g of sodium hydride was added, and the mixture was stirred at 50 ° C. for 1 hour. After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with dichloromethane. The combined organic layers were washed with water and saturated brine, and then dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 9: 1 → 8: 2). Recrystallization from a mixed solvent of dichloromethane-ethyl acetate-diisopropyl ether gave (R) -2-methyl-6-nitro-2- {4- [4- (3-trifluoromethoxybenzyl) piperidine-1] as pale yellow powder crystals. There was obtained 0.80 g (33.8%) of -yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole.
Melting point: 187.4-189.8 [deg.] C.

Example 1481
(R) -2-Methyl-2- [4- {4- [N-methyl-N- (5-chlorobenzofuran-2-ylmethyl) amino] piperidin-1-yl} phenoxymethyl] -6-nitro-2 , 3-Dihydroimidazo [2,1-b] oxazole (R) -2-Methyl-2- [4- {4- [N-methyl-N-tert-butoxycarbonylamino] piperidin-1-yl} 0.80 g of phenoxymethyl] -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole was dissolved in 2 ml of trifluoroacetic acid and 2 ml of dichloromethane, and stirred at room temperature for 15 hours. The reaction solution was concentrated under reduced pressure, and 2 ml each of dichloromethane and triethylamine were added. After stirring at room temperature for 5 minutes, the mixture was concentrated under reduced pressure. The residue was dissolved in 8 ml of dichloroethane, and 0.59 g of 5-chlorobenzofuran-2-carbaldehyde and 0.70 g of sodium triacetoxyborohydride were added under ice cooling, and the mixture was warmed to room temperature and stirred for 22 hours. An aqueous potassium carbonate solution and dichloromethane were added to the reaction mixture, and the mixture was stirred and extracted with dichloromethane. The organic layer was dried over magnesium sulfate and then filtered. The resulting filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: methanol = 9: 1). Crystallization from acetone gave yellow powder (R) -2-methyl-2- [4- {4- [N-methyl-N- (5-chlorobenzofuran-2-ylmethyl) amino] piperidin-1-yl. } Phenoxymethyl] -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole (0.65 g, yield 66.5%) was obtained.
Melting point: 207.4-210.0 ° C.

Example 1482
(R) -2-Methyl-6-nitro-2- {6- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] pyridin-3-yloxymethyl} -2,3-dihydroimidazo [ Preparation of 2,1-b] oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 2.63 g and 3-hydroxy-6- [ 3.41 g of 4- (4-trifluoromethoxybenzyl) piperidin-1-yl] pyridine was dissolved in DMF (6.7 ml), 0.46 g of sodium hydride was added, and the mixture was stirred at 50 ° C. for 1.5 hours. . After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with dichloromethane. The combined organic layers were washed with water and saturated brine, and then dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 9: 1 → 6: 4). Recrystallization from a mixed solvent of ethyl acetate-diisopropyl ether gave (R) -2-methyl-6-nitro-2- {6- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] as pale yellow powder crystals. ] 1.46 g (28.3%) of pyridin-3-yloxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 200.1-202.9 ° C.

Example 1483
(R) -6-nitro-2- [4- {4- [2- (4-trifluoromethoxyphenyl) ethyl] piperidin-1-yl} phenoxymethyl] -2,3-dihydroimidazo [2,1- b] Preparation of oxazole (R) -2-Chloro-1-oxiranylmethyl-4-nitro-1H-imidazole 0.75 g and 4- {4- [2- (4-trifluoromethoxyphenyl) ethyl] piperidine -1-yl} phenol (1.07 g) was dissolved in DMF (11 ml), sodium hydride (0.14 g) was added, and the mixture was stirred at 50 ° C. for 1 hour. After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with dichloromethane. The combined organic layers were washed with water and saturated brine, and then dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 9: 1 → 6: 4). Recrystallization from a mixed solvent of dichloromethane-diisopropyl ether gave (R) -6-nitro-2- [4- {4- [2- (4-trifluoromethoxyphenyl) ethyl] piperidin-1-yl as pale yellow powder crystals. } Phenoxymethyl] -2,3-dihydroimidazo [2,1-b] oxazole 0.31 g (19.8%) was obtained.
Melting point: 208.9-211.7 ° C.

Example 1484
(R) -2-methyl-2- [4- {4- [N-methyl-N- (4-trifluoromethoxycinnamyl) amino] piperidin-1-yl} phenoxymethyl] -6-nitro-2, Preparation of 3-dihydroimidazo [2,1-b] oxazole (R) -2-Methyl-2- [4- {4- [N-methyl-N-tert-butoxycarbonylamino] piperidin-1-yl} phenoxy 2.76 g of methyl] -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole was dissolved in 5 ml of trifluoroacetic acid and 10 ml of dichloromethane and stirred at room temperature for 0.5 hour. The reaction mixture was concentrated under reduced pressure, and 10 ml each of dichloromethane and N, N-dimethylethylamine were added. After stirring at room temperature for 10 minutes, the mixture was concentrated under reduced pressure. The residue was dissolved in 30 ml of dichloroethane, and 1.43 g of 4-trifluoromethoxycinnamyl aldehyde and 1.78 g of sodium triacetoxyborohydride were added under ice cooling, and the mixture was warmed to room temperature and stirred overnight. An aqueous potassium carbonate solution and dichloromethane were added to the reaction mixture, and the mixture was stirred and extracted with dichloromethane. The organic layer was dried over magnesium sulfate and then filtered. The resulting filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: acetone = 5: 1 → 1: 1). Recrystallization from water-containing acetone gave (R) -2-methyl-2- [4- {4- [N-methyl-N- (4-trifluoromethoxycinnamyl) amino] piperidine-1- as a pale yellow powder. Yl} phenoxymethyl] -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole (1.976 g, yield 58.9%).
Melting point: 213.0-214.9 ° C.

Example 1485
(R) -2- {4- [4- (3,4-Dichlorocinnamyl) piperazin-1-yl] phenoxymethyl} -2-methyl-6-nitro-2,3-dihydroimidazo [2,1- b] Preparation of Oxazole (R) -2-Methyl-2- [4- (4-tert-butoxycarbonylpiperazin-1-yl) phenoxymethyl] -6-nitro-2,3-dihydroimidazo [2,1- b] 2.76 g of oxazole was dissolved in 5 ml of trifluoroacetic acid and 10 ml of dichloromethane and stirred at room temperature for 0.5 hour. The reaction mixture was concentrated under reduced pressure, and 10 ml each of dichloromethane and N, N-dimethylethylamine were added. After stirring at room temperature for 5 minutes, the mixture was concentrated under reduced pressure. The residue was dissolved in 30 ml of dichloroethane, 1.33 g of 3,4-dichlorocinnamyl aldehyde and 1.78 g of sodium triacetoxyborohydride were added, and the mixture was stirred at room temperature overnight. An aqueous potassium carbonate solution and dichloromethane were added to the reaction mixture, and the mixture was stirred and extracted with dichloromethane. The organic layer was dried over magnesium sulfate and then filtered. The resulting filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: acetone = 5: 1 → 1: 1). Crystallization from a dichloromethane-ethyl acetate mixed solvent gave (R) -2- {4- [4- (3,4-dichlorocinnamyl) piperazin-1-yl] phenoxymethyl} -2-methyl as a pale yellow powder. 6.243 g (yield 68.7%) of -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 204.7-206.4 ° C.

Example 1486
(R) -2-methyl-2- [4- {N-methyl-N- [1- (4-trifluoromethoxyphenyl) piperidin-4-ylmethyl] amino} phenoxymethyl] -6-nitro-2,3 Preparation of dihydroimidazo [2,1-b] oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 0.408 g and 4- { 0.57 g of N-methyl-N- [1- (4-trifluoromethoxyphenyl) piperidin-4-ylmethyl] amino} phenol is dissolved in 6 ml of DMF, 72 mg of sodium hydride is added, and 50 to 60 ° C. for 2 hours. Stir. After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The combined organic layers were washed with water and saturated brine, and then dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane: ethyl acetate = 1: 3 → dichloromethane: ethyl acetate = 1: 1). (R) -2-methyl-2- [4- {N-methyl-N- [1- (4-trifluoromethoxyphenyl) piperidin-4-ylmethyl] amino} recrystallized from water-containing acetone 0.130 g (yield 15.4%) of phenoxymethyl] -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 172.5-175.2 ° C.

Example 1487
(R) -2-methyl-2- [4- {N-methyl-N- [1- (4-trifluoromethoxyphenyl) piperidin-4-yl] amino} phenoxymethyl] -6-nitro-2,3 Preparation of dihydroimidazo [2,1-b] oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 0.131 g and 4- { 0.177 g of N-methyl-N- [1- (4-trifluoromethoxyphenyl) piperidin-4-yl] amino} phenol is dissolved in 4 ml of DMF, 23 mg of sodium hydride is added, and 50 to 60 ° C. for 2 hours. Stir. After allowing to cool to room temperature, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The combined organic layers were washed with water and saturated brine, and then dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane: ethyl acetate = 1: 3 → dichloromethane: ethyl acetate = 1: 1). (R) -2-methyl-2- [4- {N-methyl-N- [1- (4-trifluoromethoxyphenyl) piperidin-4-yl] amino was recrystallized from water-containing acetone. } Phenoxymethyl] -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole (93 mg, yield 35%) was obtained.
Melting point: 137.9-139.2 ° C.

Example 1488
(R) -2-Methyl-6-nitro-2- [4- {1- [2- (4-trifluoromethylphenyl) thiazol-4-ylmethyl] piperidin-4-yl} phenoxymethyl] -2,3 -Preparation of dihydroimidazo [2,1-b] oxazole (R) -2-methyl-6-nitro-2- [4- (1-tert-butoxycarbonylpiperidin-4-yl) phenoxymethyl] -2,3 -0.300 g of dihydroimidazo [2,1-b] oxazole was added to 1 ml of trifluoroacetic acid and 1 ml of dichloromethane, and the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated under reduced pressure, the residue was dissolved in 1 ml of dichloromethane, 1 ml of triethylamine was added, and the mixture was stirred at room temperature for 5 minutes, and then concentrated under reduced pressure. The residue was dissolved in 5 ml of methanol, and 0.219 g of 2- (4-trifluoromethylphenyl) thiazole-4-carbaldehyde, 82 mg of sodium cyanotrihydroborate and 0.5 ml of acetic acid were added under ice cooling at room temperature. Stir for 3 days. Saturated aqueous sodium hydrogen carbonate solution was added and stirred, extracted with ethyl acetate, and washed with saturated brine. The organic layer was dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: acetone = 3: 1 → dichloromethane: methanol = 20: 1). Recrystallization from water-containing acetone gave white powder of (R) -2-methyl-6-nitro-2- [4- {1- [2- (4-trifluoromethylphenyl) thiazol-4-ylmethyl] piperidine- 4-yl} phenoxymethyl] -2,3-dihydroimidazo [2,1-b] oxazole 65 mg (yield 16.6%) was obtained.
Melting point: 194.6-196.4 ° C.

Example 1489
(R) -2-Methyl-6-nitro-2- {4- [1- (4-trifluoromethylcinnamyl) piperidin-4-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1- b] Preparation of Oxazole (R) -2-Methyl-6-nitro-2- [4- (1-tert-butoxycarbonylpiperidin-4-yl) phenoxymethyl] -2,3-dihydroimidazo [2,1- b] 0.300 g of oxazole was added to 1 ml of trifluoroacetic acid and 1 ml of dichloromethane, and the mixture was stirred for 1 hour at room temperature. The reaction solution was concentrated under reduced pressure, the residue was dissolved in 1 ml of dichloromethane, 1 ml of triethylamine was added, and the mixture was stirred at room temperature for 5 minutes, and then concentrated under reduced pressure. The residue was dissolved in 5 ml of methanol, and 0.170 g of 4-trifluoromethylcinnamylaldehyde, 82 mg of sodium cyanotrihydroborate and 0.5 ml of acetic acid were added under ice cooling, and the mixture was stirred at room temperature for 3 days. Saturated aqueous sodium hydrogen carbonate solution was added and stirred, extracted with ethyl acetate, and washed with saturated brine. The organic layer was dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: acetone = 3: 1 → dichloromethane: methanol = 20: 1). Recrystallization from water-containing acetone gave ((R) -2-methyl-6-nitro-2- {4- [1- (4-trifluoromethylcinnamyl) piperidin-4-yl] phenoxymethyl} as white powder. 66 mg (yield 18.6%) of -2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 185.9-187.1 [deg.] C.

Example 1490
(R) -2-Methyl-6-nitro-2- [4-{4- [2- (4-trifluoromethoxyphenoxy) ethyl] piperazin-1-yl} phenoxymethyl] -2,3-dihydroimidazo Preparation of [2,1-b] oxazole (R) -2-Methyl-6-nitro-2- [4- (4-tert-butoxycarbonylpiperazin-1-yl) phenoxymethyl] -2,3-dihydroimidazo 0.300 g of [2,1-b] oxazole was added to 3 ml of trifluoroacetic acid and 3 ml of dichloromethane, and the mixture was stirred at room temperature for 2 hours. The reaction solution was concentrated under reduced pressure, the residue was dissolved in 3 ml of dichloromethane, 3 ml of triethylamine was added, and the mixture was stirred at room temperature for 10 minutes and then concentrated under reduced pressure. The residue was dissolved in 5 ml of methanol, and 0.170 g of 4-trifluoromethoxyphenoxyacetaldehyde, 82 mg of sodium cyanotrihydroborate and 0.1 ml of acetic acid were added under ice cooling, and the mixture was stirred overnight at room temperature. Saturated aqueous sodium hydrogen carbonate solution was added and stirred, extracted with ethyl acetate, and washed with saturated brine. The organic layer was dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: acetone = 3: 1 → dichloromethane: methanol = 20: 1). Recrystallization from water-containing acetone gave ((R) -2-methyl-6-nitro-2- {4- [1- (4-trifluoromethylcinnamyl) piperidin-4-yl] phenoxymethyl} as white powder. 157 mg (yield 42.7%) of -2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 194.8-195.6 ° C.

Example 1491
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylcinnamyl) piperazin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1- b] Preparation of Oxazole (R) -2-Methyl-6-nitro-2- [4- (4-tert-butoxycarbonylpiperazin-1-yl) phenoxymethyl] -2,3-dihydroimidazo [2,1- b] 0.300 g of oxazole was added to 3 ml of trifluoroacetic acid and 3 ml of dichloromethane, and the mixture was stirred for 1 hour at room temperature. The reaction solution was concentrated under reduced pressure, the residue was dissolved in 3 ml of dichloromethane, 3 ml of triethylamine was added, and the mixture was stirred at room temperature for 5 minutes and then concentrated under reduced pressure. The residue was dissolved in 5 ml of methanol, and 0.170 g of 4-trifluoromethylcinnamylaldehyde, 82 mg of sodium cyanotrihydroborate and 0.1 ml of acetic acid were added under ice cooling, and the mixture was stirred at room temperature for 3 days. Saturated aqueous sodium hydrogen carbonate solution was added and stirred, extracted with ethyl acetate, and washed with saturated brine. The organic layer was dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: acetone = 3: 1 → dichloromethane: methanol = 20: 1). Recrystallization from water-containing acetone gave (R) -2-methyl-6-nitro-2- {4- [4- (4-trifluoromethylcinnamyl) piperazin-1-yl] phenoxymethyl} as a pale yellow powder 66 mg (yield 18.6%) of -2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 199.7-202.0 ° C.

Example 1492
(R) -2-Methyl-6-nitro-2- [4- {4- [2- (4-trifluoromethylphenyl) thiazol-4-ylmethyl] piperazin-1-yl} phenoxymethyl] -2,3 Preparation of dihydroimidazo [2,1-b] oxazole (R) -2-Methyl-6-nitro-2- [4- (4-tert-butoxycarbonylpiperazin-1-yl) phenoxymethyl] -2,3 -0.300 g of dihydroimidazo [2,1-b] oxazole was added to 3 ml of trifluoroacetic acid and 3 ml of dichloromethane, and the mixture was stirred at room temperature for 2 hours. The reaction solution was concentrated under reduced pressure, the residue was dissolved in 3 ml of dichloromethane, 3 ml of triethylamine was added, and the mixture was stirred at room temperature for 10 minutes and then concentrated under reduced pressure. The residue was dissolved in 5 ml of methanol, and 0.218 g of 2- (4-trifluoromethylphenyl) thiazole-4-carbaldehyde, 82 mg of sodium cyanotrihydroborate and 0.5 ml of acetic acid were added under ice cooling at room temperature. Stir overnight. Saturated aqueous sodium hydrogen carbonate solution was added and stirred, extracted with ethyl acetate, and washed with saturated brine. The organic layer was dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: acetone = 3: 1 → dichloromethane: methanol = 20: 1). Recrystallization from water-containing acetone gave white powder of (R) -2-methyl-6-nitro-2- [4- {4- [2- (4-trifluoromethylphenyl) thiazol-4-ylmethyl] piperazine- 1-yl} phenoxymethyl] -2,3-dihydroimidazo [2,1-b] oxazole 0.167 g (yield 42.6%) was obtained.
Melting point: 210.0-212.1 ° C.

Example 1493
(R) -2- [4- {4- [N- (4-Chlorophenyl) -N-methylamino] piperidin-1-yl} phenoxymethyl] -2-methyl-6-nitro-2,3-dihydroimidazo Preparation of [2,1-b] oxazole 776 mg of 4- {4- [N- (4-chlorophenyl) -N-methylamino] piperidin-1-yl} phenol is dissolved in 10 ml of DMF, and 108 mg of sodium hydride is added thereto. Stir at ˜80 ° C. for 10 minutes. The reaction mixture was ice-cooled, (R) -2-chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole (746 mg) was added, and the mixture was stirred at 70-80 ° C. for 20 min. . After allowing to cool to room temperature, ice water was added to the reaction mixture and stirred, and the resulting insoluble material was collected by filtration. The residue was dissolved in dichloromethane, washed with saturated brine, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 10: 1). Recrystallization from a dichloromethane-ethyl acetate mixed solvent gave (R) -2- [4- {4- [N- (4-chlorophenyl) -N-methylamino] piperidin-1-yl} phenoxymethyl] as white powder crystals. 485 mg (yield 39.8%) of 2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 173.7-175.1C.

Example 1494
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1- b] Preparation of Oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 574 mg and 4- [4- (4-trifluoromethylphenoxymethyl) ) Piperidin-1-yl] phenol 844 mg was heated to 140 ° C. and stirred for 4 hours. After cooling to room temperature, the residue was purified by silica gel column chromatography (n-hexane: ethyl acetate = 1: 3). After concentration, the residue was dissolved in 10 ml of DMF. Under ice-cooling, 174 mg of sodium tert-butoxide was added and stirred at room temperature for 2 hours. The solvent was distilled off under reduced pressure, and 100 ml of acetone and 10 ml of silica gel were added to the residue and concentrated. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 10: 1 to 1: 1) and recrystallized from a dichloromethane-ethyl acetate mixed solvent to give (R) -2-methyl-6-nitro- 1.15 g (38% yield) of 2- {4- [4- (4-trifluoromethylphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole )Obtained.
Melting point: 223.2-225.2 ° C. (decomposition).

Example 1495
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylbenzyloxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1 -B] Preparation of oxazole 2.48 g of 4- [4- (4-trifluoromethylbenzyloxymethyl) piperidin-1-yl] phenol was dissolved in 30 ml of DMF, 312 mg of sodium hydride was added, Stir for minutes. The reaction mixture was ice-cooled, (R) -2-chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole (2.07 g) was added, and the mixture was stirred at 70-80 ° C. for 20 minutes. Stir. After allowing to cool to room temperature, ice water was added to the reaction mixture and stirred, and the resulting insoluble material was collected by filtration. The residue was dissolved in dichloromethane, washed with saturated brine, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 10: 1). (R) -2-methyl-6-nitro-2- {4- [4- (4-trifluoromethylbenzyloxymethyl) piperidin-1-yl] phenoxymethyl} recrystallized from ethyl acetate There was obtained 1.66 g (yield 44.7%) of -2,3-dihydroimidazo [2,1-b] oxazole.
Melting point: 172.3-172.9 [deg.] C.

Example 1496
(R) -2-Methyl-6-nitro-2- {4- [4- (4-chloromethylphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b Production of Oxazole 1.09 g of 4- [4- (4-chloromethylphenoxymethyl) piperidin-1-yl] phenol was dissolved in 20 ml of DMF, 158 mg of sodium hydride was added, and the mixture was stirred at 70-80 ° C. for 20 minutes. The reaction solution was ice-cooled, 1.04 g of (R) -2-chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole was added, and the mixture was stirred at 60 ° C. for 30 minutes. . After allowing to cool to room temperature, ice water was added to the reaction mixture and stirred, and the resulting insoluble material was collected by filtration. The residue is dissolved in dichloromethane, washed with saturated brine, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: methanol = 20: 1). Recrystallization from ethyl acetate gave pale yellow powdered crystals of (R) -2-methyl-6-nitro-2- {4- [4- (4-chloromethylphenoxymethyl) piperidin-1-yl] phenoxymethyl}- 744 mg (43.5% yield) of 2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 140.4-141.7 ° C.

Example 1497
(R) -6-nitro-2- {4- [4- (4-trifluoromethylphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole Preparation 1.22 grams of 4- [4- (4-trifluoromethylphenoxymethyl) piperidin-1-yl] phenol was dissolved in 15 ml of DMF, 196 mg of sodium hydride was added, and the mixture was stirred at 70 to 80 ° C. for 30 minutes. The reaction mixture was ice-cooled, 1.57 g of (R) -2-chloro-1-oxiranylmethyl-4-nitro-1H-imidazole was added, and the mixture was stirred at 80 ° C. for 20 min. After allowing to cool to room temperature, ice water was added to the reaction mixture and stirred, and the resulting insoluble material was collected by filtration. The residue was dissolved in dichloromethane, washed with saturated brine, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: methanol = 20: 1). Recrystallization from ethyl acetate gave white powdered crystals of (R) -6-nitro-2- {4- [4- (4-trifluoromethylphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3- 505 mg (yield 22.1%) of dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 175.0-180 ° C.

Example 1498
(R) -2- {4 ′-[4- (4-Chlorobenzyl) piperazin-1-yl] biphenyl-4-yloxymethyl} -2-methyl-6-nitro-2,3-dihydroimidazo [2 , 1-b] Preparation of oxazole (R) -2-Methyl-2- [4 ′-(4-tert-butoxycarbonylpiperazin-1-yl) biphenyl-4-yloxymethyl] -6-nitro-2, 850 mg of 3-dihydroimidazo [2,1-b] oxazole was dissolved in 10 ml of trifluoroacetic acid and 5 ml of dichloromethane, and stirred overnight at room temperature. The reaction mixture was concentrated under reduced pressure, and 6 ml each of dichloromethane and triethylamine were added. After stirring at room temperature for 5 minutes, the mixture was concentrated under reduced pressure. The residue was dissolved in 10 ml of DMF, 444.2 mg of 4-chlorobenzaldehyde and 672 mg of sodium triacetoxyborohydride were added under ice cooling, and the mixture was stirred overnight at room temperature. An aqueous sodium hydrogen carbonate solution and ethyl acetate were added to the reaction mixture and stirred, and the resulting insoluble material was collected by filtration. (R) -2- {4 ′-[4- (4-Chlorobenzyl) piperazin-1-yl] biphenyl-4-yloxymethyl} -2 was obtained by washing with water and ethyl acetate and then drying. 730 mg (yield 51.8%) of -methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 247.8-248.5 [deg.] C. (decomposition).

Example 1499
(R) -2-Methyl-6-nitro-2- {4 ′-[4- (4-trifluoromethylbenzyl) piperazin-1-yl] biphenyl-4-yloxymethyl} -2,3-dihydroimidazo Preparation of [2,1-b] oxazole (R) -2-Methyl-2- [4 ′-(4-tert-butoxycarbonylpiperazin-1-yl) biphenyl-4-yloxymethyl] -6-nitro- 790 mg of 2,3-dihydroimidazo [2,1-b] oxazole was dissolved in 10 ml of trifluoroacetic acid and 5 ml of dichloromethane, and stirred overnight at room temperature. The reaction mixture was concentrated under reduced pressure, and 6 ml each of dichloromethane and triethylamine were added. After stirring at room temperature for 5 minutes, the mixture was concentrated under reduced pressure. The residue was dissolved in 15 ml of DMF, 0.4 ml of 4-trifluoromethylbenzaldehyde and 625 mg of sodium triacetoxyborohydride were added under ice cooling, and the mixture was stirred overnight at room temperature. Water was added to the reaction solution and stirred, and the resulting insoluble material was collected by filtration. After washing with water, the residue was dissolved in dichloromethane, washed with saturated brine, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: methanol = 20: 1). Recrystallization from a mixed solvent of dichloromethane and ethyl acetate gave (R) -2-methyl-6-nitro-2- {4 ′-[4- (4-trifluoromethoxybenzyl) piperazin-1-yl] as a pale yellow powder. Biphenyl-4-yloxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole (585 mg, yield 60.5%) was obtained.
Melting point: 247.7-248.4 ° C. (decomposition).

Example 1500
(R) -2-Methyl-6-nitro-2- [4- {4- [2- (4-trifluoromethoxybenzyloxy) ethyl] piperidin-1-yl} phenoxymethyl] -2,3-dihydroimidazo Preparation of [2,1-b] oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 959 mg and 4- {4- [2- 1.24 g of (4-trifluoromethoxybenzyloxy) ethyl] piperidin-1-yl} phenol was dissolved in 20 ml of DMF, 176 mg of sodium hydride was added, and the mixture was stirred at 55 ° C. for 1 hour. After allowing to cool to room temperature, ice water was added to the reaction solution and stirred, and the resulting insoluble material was collected by filtration. The residue was dissolved in dichloromethane, washed with saturated brine, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 10: 1). Recrystallization from a dichloromethane-ethyl acetate mixed solvent gave white powdered crystals of (R) -2-methyl-6-nitro-2- [4- {4- [2- (4-trifluoromethoxybenzyloxy) ethyl] piperidine. -1-yl} phenoxymethyl] -2,3-dihydroimidazo [2,1-b] oxazole (562 mg, yield 28.8%) was obtained.
Melting point: 204.8-206.7 ° C.

Example 1501
(R) -2-Methyl-6-nitro-2- [4- {4- [2- (4-trifluoromethylbenzyloxy) ethyl] piperidin-1-yl} phenoxymethyl] -2,3-dihydroimidazo Preparation of [2,1-b] oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 741 mg and 4- {4- [2- 1.00 g of (4-trifluoromethylbenzyloxy) ethyl] piperidin-1-yl} phenol was dissolved in 10 ml of DMF, 136 mg of sodium hydride was added, and the mixture was stirred at 55 ° C. for 1 hour. After allowing to cool to room temperature, ice water was added to the reaction mixture and stirred, and the resulting insoluble material was collected by filtration. The residue was dissolved in dichloromethane, washed with saturated brine, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 10: 1). Recrystallization from a dichloromethane-ethyl acetate mixed solvent gave white powdered crystals of (R) -2-methyl-6-nitro-2- [4- {4- [2- (4-trifluoromethylbenzyloxy) ethyl] piperidine. -1-yl} phenoxymethyl] -2,3-dihydroimidazo [2,1-b] oxazole (548 mg, yield 37.3%) was obtained.
Melting point: 198.0-199.2 ° C.

Example 1502
(R) -2- [4- {4- [2- (4-Chlorobenzyloxy) ethyl] piperidin-1-yl} phenoxymethyl] -2-methyl-6-nitro-2,3-dihydroimidazo [2 , 1-b] Oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 900 mg and 4- {4- [2- (4 -Chlorobenzyloxy) ethyl] piperidin-1-yl} phenol 1.10 g was dissolved in 10 ml of DMF, 165 mg of sodium hydride was added, and the mixture was stirred at 55 ° C. for 1 hour. After allowing to cool to room temperature, ice water was added to the reaction mixture and stirred, and the resulting insoluble material was collected by filtration. The residue was dissolved in dichloromethane, washed with saturated brine, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 10: 1). Recrystallization from a dichloromethane-ethyl acetate mixed solvent gave (R) -2- [4- {4- [2- (4-chlorobenzyloxy) ethyl] piperidin-1-yl} phenoxymethyl] -2 as white powder crystals. 548 mg (yield 37.3%) of -methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole were obtained.
Melting point: 197.6-198.2 ° C.

Example 1503
(R) -2-Methyl-6-nitro-2- (4- [4- {4- [4- (4-trifluoromethoxyphenoxy) piperidin-1-yl] benzyl} piperazin-1-yl] phenoxymethyl ) -2,3-Dihydroimidazo [2,1-b] oxazole Preparation (R) -2-Methyl-2- [4- (4-tert-butoxycarbonylpiperazin-1-yl) phenoxymethyl] -6 350 mg of nitro-2,3-dihydroimidazo [2,1-b] oxazole was dissolved in 10 ml of trifluoroacetic acid and stirred at room temperature for 5 hours. The reaction solution was concentrated under reduced pressure, and 2 ml each of dichloromethane and triethylamine were added. After stirring at room temperature for 5 minutes, the mixture was concentrated under reduced pressure. The residue was dissolved in 10 ml of dichloroethane, 278 mg of 4- [4- (4-trifluoromethoxyphenoxy) piperidin-1-yl] benzaldehyde and 242 mg of sodium triacetoxyborohydride were added under ice cooling, and the mixture was stirred overnight at room temperature. An aqueous sodium hydrogen carbonate solution was added to the reaction mixture, and the mixture was extracted with dichloromethane. The extract was washed with saturated brine and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 10: 1). Recrystallization from a dichloromethane-diisopropyl ether mixed solvent gave (R) -2-methyl-6-nitro-2- (4- [4- {4- [4- (4-trifluoromethoxyphenoxy)] as a pale yellow powder. 295 mg (55% yield) of piperidin-1-yl] benzyl} piperazin-1-yl] phenoxymethyl) -2,3-dihydroimidazo [2,1-b] oxazole were obtained.
Melting point: 198.2-201.4 ° C.

Example 1504
(R) -2- {4 ′-[4- (3,4-Dichlorobenzyl) piperazin-1-yl] biphenyl-4-yloxymethyl} -2-methyl-6-nitro-2,3-dihydroimidazo Preparation of [2,1-b] oxazole (R) -2-Methyl-2- [4 ′-(4-tert-butoxycarbonylpiperazin-1-yl) biphenyl-4-yloxymethyl] -6-nitro- 350 mg of 2,3-dihydroimidazo [2,1-b] oxazole was dissolved in 10 ml of trifluoroacetic acid and stirred at room temperature for 5 hours. The reaction solution was concentrated under reduced pressure, and 2 ml each of dichloromethane and triethylamine were added. After stirring at room temperature for 5 minutes, the mixture was concentrated under reduced pressure. The residue was dissolved in 10 ml of dichloroethane, added with 278 mg of 3,4-dichlorobenzaldehyde and 242 mg of sodium triacetoxyborohydride under ice cooling, and stirred overnight at room temperature. Water was added to the reaction solution and stirred, and the resulting insoluble material was collected by filtration. The residue was dissolved in dichloromethane, washed with saturated brine, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: methanol = 20: 1) to give (R) -2- {4 ′-[4- (3,4-dichlorobenzyl) piperazin-1-yl] as a pale yellow powder. Biphenyl-4-yloxymethyl} -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole 252 mg (yield 41.1%) was obtained.
Melting point: 222.6-225.1 ° C. (decomposition).

Example 1505
(R) -2-Methyl-6-nitro-2- [4- {4- [4- (4-trifluoromethoxyphenoxy) phenylamino] piperidin-1-yl} phenoxymethyl] -2,3-dihydroimidazo Preparation of [2,1-b] oxazole (R) -2-Methyl-6-nitro-2- [4- (4-oxopiperidin-1-yl) phenoxymethyl] -2,3-dihydroimidazo [2, 1-b] Oxazole 400 mg of dichloroethane solution (10 ml) was added with 376 mg of 4- (4-trifluoromethoxyphenoxy) aniline and 453 mg of sodium triacetoxyborohydride and stirred overnight at room temperature. Saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, and the mixture was extracted with dichloromethane. The organic layer was dried over magnesium sulfate and then filtered. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (dichloromethane: methanol = 20: 1). Recrystallization from a dichloromethane-diisopropyl ether mixed solvent gave (R) -2-methyl-6-nitro-2- [4- {4- [4- (4-trifluoromethoxyphenoxy) phenylamino] piperidine as white powder. 650 mg (yield: 83.2%) of -1-yl} phenoxymethyl] -2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 198.6-201.1 ° C. (decomposition).

Example 1506
(R) -2-methyl-6-nitro-2- (4- [4- {N-methyl-N- [3- (4-trifluoromethoxyphenoxy) propyl] amino} piperidin-1-yl] phenoxymethyl ) -2,3-Dihydroimidazo [2,1-b] oxazole Preparation (R) -2-Methyl-6-nitro-2- [4- {4- [3- (4-trifluoromethoxyphenoxy) propyl Amino] piperidin-1-yl} phenoxymethyl] -2,3-dihydroimidazo [2,1-b] oxazole 237 mg was dissolved in a mixed solvent of 10 ml of dichloromethane and 10 ml of methanol, 0.15 ml of 30% aqueous formaldehyde solution, cyanotri 71.4 mg of sodium hydroborate and 0.01 ml of acetic acid were added, and the mixture was stirred overnight at room temperature. Saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, and the mixture was extracted with dichloromethane. The organic layer was dried over magnesium sulfate and then filtered. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (dichloromethane: methanol = 20: 1). Recrystallization from a mixed solvent of dichloromethane-diisopropyl ether gave (R) -2-methyl-6-nitro-2- (4- [4- {N-methyl-N- [3- (4-tri 215 mg (88.7% yield) of fluoromethoxyphenoxy) propyl] amino} piperidin-1-yl] phenoxymethyl) -2,3-dihydroimidazo [2,1-b] oxazole were obtained.
Melting point: 167.4-170.2 [deg.] C.

Example 1507
(R) -2- {4- [4- (3,4-Dichlorophenylamino) piperidin-1-yl] phenoxymethyl} -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b Preparation of oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole (628 mg) and 4- [4- (3,4-dichlorophenylamino) piperidine -1-yl] phenol 750 mg was dissolved in DMF 10 ml, sodium hydride 117 mg was added, and the mixture was stirred at 60 ° C. for 20 minutes. After cooling to room temperature, water was added to the reaction solution, and the insoluble matter produced was collected by filtration. The residue was dissolved in dichloromethane, washed with saturated brine, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 9: 1 → 8: 2). Recrystallization from a dichloromethane-diisopropyl ether mixed solvent gave (R) -2- {4- [4- (3,4-dichlorophenylamino) piperidin-1-yl] phenoxymethyl} -2-methyl- 441 mg (yield 39%) of 6-nitro-2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 146-17.4 ° C.

Example 1508
(R) -2-methyl-6-nitro-2- (4- [4- {N-methyl-N- [2- (4-trifluoromethoxyphenoxy) ethyl] amino} piperidin-1-yl] phenoxymethyl ) -2,3-Dihydroimidazo [2,1-b] oxazole Preparation (R) -2-Methyl-6-nitro-2- [4- {4- [2- (4-trifluoromethoxyphenoxy) ethyl] 200 mg of [amino] piperidin-1-yl} phenoxymethyl] -2,3-dihydroimidazo [2,1-b] oxazole was dissolved in a mixed solvent of 2 ml of dichloromethane and 2 ml of methanol, 0.13 ml of 30% aqueous formaldehyde solution, Sodium hydroborate (65 mg) and acetic acid (0.07 ml) were added, and the mixture was stirred at room temperature overnight. Saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, and the mixture was extracted with dichloromethane. The organic layer was dried over magnesium sulfate and then filtered. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (dichloromethane: methanol = 20: 1). Recrystallization from a dichloromethane-diisopropyl ether mixed solvent gave (R) -2-methyl-6-nitro-2- (4- [4- {N-methyl-N- [2- (4-trifluoro) as a white powder. There were obtained 155 mg (yield 75.7%) of methoxyphenoxy) ethyl] amino} piperidin-1-yl] phenoxymethyl) -2,3-dihydroimidazo [2,1-b] oxazole.
Melting point: 185.7-187.7 ° C.

Example 1509
(R) -2-Methyl-6-nitro-2- [4- {4- [4- (4-trifluoromethoxyphenyl) piperazin-1-yl] piperidin-1-yl} phenoxymethyl] -2,3 Preparation of dihydroimidazo [2,1-b] oxazole (R) -2-methyl-6-nitro-2- [4- (4-oxopiperidin-1-yl) phenoxymethyl] -2,3-dihydroimidazo 145 mg of 1- (4-trifluoromethoxyphenyl) piperazine, 273 mg of sodium triacetoxyborohydride and 0.061 ml of acetic acid were added to an acetonitrile solution (15 ml) of [2,1-b] oxazole (15 ml), and the mixture was stirred at room temperature for 11 days. . Saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, and the mixture was extracted with dichloromethane. The organic layer was dried over sodium sulfate and filtered. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (dichloromethane: methanol = 20: 1). Recrystallization from isopropyl alcohol gave (R) -2-methyl-6-nitro-2- [4- {4- [4- (4-trifluoromethoxyphenyl) piperazin-1-yl] piperidine- 143 mg (yield 44.2%) of 1-yl} phenoxymethyl] -2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 279-281 [deg.] C.

Example 1510
(R) -2- {4- [4- (3,5-dichlorophenylamino) piperidin-1-yl] phenoxymethyl} -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b Preparation of oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole (1.82 g) and 4- [4- (3,5-dichlorophenylamino) ) Piperidin-1-yl] phenol (2.02 g) was dissolved in 20 ml of DMF, 264 mg of sodium hydride was added, and the mixture was stirred at 60 ° C. for 20 minutes. After allowing to cool to room temperature, water and ethyl acetate were added to the reaction mixture and stirred, and the resulting insoluble material was collected by filtration. The residue was dissolved in dichloromethane, washed with saturated brine, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 9: 1 → dichloromethane: methanol = 20: 1). Recrystallization from an ethyl acetate-diethyl ether mixed solvent gave pale yellow powdered crystals of (R) -2- {4- [4- (3,5-dichlorophenylamino) piperidin-1-yl] phenoxymethyl} -2-methyl 1.19 g (yield 38%) of -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 122-124 ° C.

Example 1511
(R) -2- [4- {4- [4- (4-Chlorophenyl) piperazin-1-yl] piperidin-1-yl} phenoxymethyl] -2-methyl-6-nitro-2,3-dihydroimidazo Preparation of [2,1-b] oxazole To a solution (10 ml) of 290 mg of 1- (4-chlorophenyl) piperazine dihydrochloride was added 10 ml of a 20% aqueous sodium carbonate solution and irradiated with ultrasonic waves. After extraction with dichloromethane and drying with sodium sulfate, the solvent was distilled off under reduced pressure. The residue is dissolved in 15 ml of dichloroethane and (R) -2-methyl-6-nitro-2- [4- (4-oxopiperidin-1-yl) phenoxymethyl] -2,3-dihydroimidazo [2,1- b] 200 mg of oxazole, 341 mg of sodium triacetoxyborohydride and 0.092 ml of acetic acid were added and stirred at room temperature for 24 hours. A 20% aqueous sodium carbonate solution was added to the reaction mixture, and the mixture was concentrated under reduced pressure. Water was added to the residue, and the insoluble matter produced was collected by filtration. The filtrate was washed with water, dried, and recrystallized from isopropyl alcohol to give (R) -2- [4- {4- [4- (4-chlorophenyl) piperazin-1-yl] piperidine- 232 mg (yield 78.1%) of 1-yl} phenoxymethyl] -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 247-249 ° C.

Example 1512
(R) -2-methyl-2- (4- [4- {4- [N-methyl-N- (4-chlorophenyl) amino] piperidin-1-yl} piperidin-1-yl] phenoxymethyl) -6 -Preparation of nitro-2,3-dihydroimidazo [2,1-b] oxazole (R) -2-Methyl-6-nitro-2- [4- (4-oxopiperidin-1-yl) phenoxymethyl]- 2,3-Dihydroimidazo [2,1-b] oxazole 200 mg in dichloroethane solution (15 ml), 241 mg of 4- [N-methyl-N- (4-chlorophenyl) amino] piperidine, 341 mg of sodium triacetoxyborohydride and acetic acid 0.092 ml was added and stirred at room temperature for 20 hours. A 20% aqueous sodium carbonate solution was added to the reaction mixture, and the mixture was extracted with dichloromethane. The organic layer was dried over sodium sulfate and filtered. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (dichloromethane: methanol = 20: 1). Recrystallization from a dichloromethane-diethyl ether mixed solvent gave (R) -2-methyl-2- (4- [4- {4- [N-methyl-N- (4-chlorophenyl) amino] piperidine- 1-yl} piperidin-1-yl] phenoxymethyl) -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole (105 mg, yield 33.6%) was obtained.
Melting point: 230.8-232 ° C.

Example 1513
(R) -2-Methyl-2- (4- [4- {4- [N-methyl-N- (4-trifluoromethoxyphenyl) amino] piperidin-1-yl} piperidin-1-yl] phenoxymethyl ) Preparation of 6-nitro-2,3-dihydroimidazo [2,1-b] oxazole (R) -2-Methyl-6-nitro-2- [4- (4-oxopiperidin-1-yl) phenoxy Methyl] -2,3-dihydroimidazo [2,1-b] oxazole in 192 mg of dichloroethane solution (15 ml) and 283 mg of 4- [N-methyl-N- (4-trifluoromethoxyphenyl) amino] piperidine, triacetoxyhydrogen 328 mg of sodium borohydride and 0.089 ml of acetic acid were added, and the mixture was stirred at room temperature for 14 hours. A 20% aqueous sodium carbonate solution was added to the reaction mixture, and the mixture was extracted with dichloromethane. The organic layer was dried over sodium sulfate and filtered. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (dichloromethane: methanol = 20: 1). Recrystallization from a dichloromethane-diethyl ether mixed solvent gave (R) -2-methyl-2- (4- [4- {4- [N-methyl-N- (4-trifluoromethoxyphenyl) amino] as a yellow powder. ] 153 mg (yield 47.1%) of piperidin-1-yl} piperidin-1-yl] phenoxymethyl) -6-nitro-2,3-dihydroimidazo [2,1-b] oxazole.
Melting point: 196-197 ° C.

Example 1514
(R) -2- {4- [4- (4-Propylphenylamino) piperidin-1-yl] phenoxymethyl} -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b] Preparation of oxazole (R) -2-Chloro-1- (2-methyl-2-oxiranylmethyl) -4-nitro-1H-imidazole 1.86 g and 4- [4- (4-propylphenylamino) piperidine -1-yl] phenol 1.9 g was dissolved in 20 ml of DMF, 269 mg of sodium hydride was added, and the mixture was stirred at 50 ° C. for 2 hours. After allowing to cool to room temperature, water and ethyl acetate were added to the reaction mixture and stirred, and the resulting insoluble material was collected by filtration. The residue was dissolved in dichloromethane, washed with saturated brine, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: ethyl acetate = 9: 1 → dichloromethane: methanol = 20: 1). Recrystallization from a mixed solvent of ethyl acetate-diisopropyl ether gave (R) -2- {4- [4- (4-propylphenylamino) piperidin-1-yl] phenoxymethyl} -2-methyl- 660 mg (yield 21.9%) of 6-nitro-2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 222-223 ° C.

Example 1515
(R) -2- [4- {4- [N-methyl-N- (4-propylphenyl) amino] piperidin-1-yl} phenoxymethyl] -2-methyl-6-nitro-2,3-dihydro Preparation of imidazo [2,1-b] oxazole (R) -2- {4- [4- (4-propylphenylamino) piperidin-1-yl] phenoxymethyl} -2-methyl-6-nitro-2, Dissolve 300 mg of 3-dihydroimidazo [2,1-b] oxazole in a mixed solvent of 4 ml of dichloromethane and 4 ml of methanol, add 0.14 ml of 30% aqueous formaldehyde solution, 115 mg of sodium cyanotrihydroborate and 0.1 ml of acetic acid, And stirred overnight. A 20% aqueous sodium carbonate solution was added to the reaction mixture, and the mixture was extracted with dichloromethane. The organic layer was dried over magnesium sulfate and then filtered. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (dichloromethane: methanol = 40: 1). Recrystallization from a mixed solvent of ethyl acetate-diisopropyl ether gave (R) -2- [4- {4- [N-methyl-N- (4-propylphenyl) amino] piperidin-1-yl} as a slightly yellow powder. 258 mg (83.6% yield) of phenoxymethyl] -2-methyl-6-nitro-2,3-dihydroimidazo [2,1-b] oxazole was obtained.
Melting point: 198-199 ° C.

Test example 1
Antibacterial test (agar plate dilution method)
For the 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound obtained in Example 129, the minimum growth inhibitory concentration against M. tuberculosis H37Rv was set to 7H11 medium (manufactured by BBL). ). The above strain is cultured in advance in a 7H9 medium (BBL), the number of viable bacteria is calculated, and a bacterial solution frozen and stored at −80 ° C. is used to prepare a final viable cell count of about 106 CFU / ml. It was. The bacterial solution thus prepared was inoculated into 5 μl of a test compound-containing 7H11 agar medium, cultured at 37 ° C. for 14 days, and then subjected to a test for measuring the minimum growth inhibitory concentration.

The minimum inhibitory concentration for M. tuberculosis H37Rv was 0.0015 μg / ml.

Test example 2
Antibacterial test (agar plate dilution method)
About the test compound shown in the following table | surface, the minimum growth inhibitory density | concentration with respect to a tuberculosis genus (M. tuberculosis Kurono) was calculated | required using 7H11 culture medium (made by BBL). The above strain is cultured in advance in a 7H9 medium (BBL), the number of viable bacteria is calculated, and a bacterial solution frozen and stored at −80 ° C. is used to prepare a final viable cell count of about 106 CFU / ml. It was. The bacterial solution thus prepared was inoculated into 5 μl of a test compound-containing 7H11 agar medium, cultured at 37 ° C. for 14 days, and then subjected to a test for measuring the minimum growth inhibitory concentration.

  The results are shown in the table below.

Claims (2)

General formula (1)

[Wherein R ¹ represents a hydrogen atom or a C 1-6 alkyl group.
n shows the integer of 0-6.
R ² represents any one of the following groups (a) to (r) .
(A) a phenyl group (on the phenyl ring, at least one piperidyl group [on the piperidine ring, at least one phenoxy group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 A group selected from the group consisting of an alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) may be substituted] may be substituted) ;
(B) a benzothiazolyloxy group (on the benzothiazole ring, (b-1) a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or At least one group selected from the group consisting of substituted C1-6 alkoxy groups may be substituted], (b-2) piperazinyl group [on the piperazine ring, a phenyl C1-6 alkyl group (phenyl On the ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. ), A phenyl C2-6 alkenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) And a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted group). And at least one group selected from the group consisting of a group selected from the group consisting of C1-6 alkoxy groups may be substituted], (b-3 ) Piperidyl group [on the piperidine ring, an amino group (on the amino group, a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1 And at least one group selected from the group consisting of -6 alkoxy groups may be substituted] and at least one group selected from the group consisting of C1-6 alkyl groups may be substituted) , Enoxy group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. And a phenyl C1-6 alkyl group (on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one group selected from the group consisting of: (b-4) a pyrrolyl group [on the pyrrole ring, C1-6 alkyl group and phenyl C1-6 alkyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen At least one group selected from the group consisting of a group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted)] And (b-5) a phenylthio group [on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; At least one of the groups selected from the group consisting of: which may be substituted] may be substituted);
(C) a quinolyloxy group (on the quinoline ring, (c-1) a halogen atom, (c-2) a phenoxy group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen At least one group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted], (c-3) piperazinyl group [on the piperazine ring, phenyl C1-6 alkyl Group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. A phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted group). May be substituted with at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups], halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups, and halogen-substituted or unsubstituted And at least one group selected from the group consisting of C1-6 alkoxy groups may be substituted) and a phenyl C2-6 alkenyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1). At least one group selected from the group consisting of -6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted). And (c-4) piperidyl group [on the piperidine ring, an amino group (on the amino group, a phenyl group [on the phenyl ring, a halogen atom, From at least one group selected from the group consisting of a rogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] and a C1-6 alkyl group At least one group selected from the group may be substituted); a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted; a phenyl C1-6 alkyl group (on the phenyl ring, a C1-4 alkylenedioxy group, a halogen atom, At least a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; 1 type may be substituted); phenyl C1-6 alkoxy group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group) At least one group selected from the group consisting of: a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted); a naphthyl C1-6 alkyl group and a phenyl C1-6 alkylidene group (on the phenyl ring, a halogen atom, From the group consisting of halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups And at least one group selected from the group consisting of a group selected from the group consisting of: a group selected from the group consisting of: May be);
(D) Pyridyloxy group (on the pyridine ring, (d-1) piperidyl group [on the piperidine ring, a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group And at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted), phenyl C1-6 alkoxy-substituted C1-6 alkyl groups (on the phenyl ring) , At least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), phenoxy C1 -6 alkyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C -6 at least one group selected from the group consisting of alkoxy groups may be substituted, and a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of an alkyl group and a group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted). And (d-2) a piperazinyl group [on the piperazine ring a C1-6 alkoxycarbonyl group, a furyl C1-6 alkyl group (on the furan ring, at least one phenyl group [on the phenyl ring] Is a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group 1 type may be substituted], a pyridyl C1-6 alkyl group (on the pyridine ring, a furyl group and a phenyl group [on the phenyl ring, a halogen atom, halogen substitution or At least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] at least of a group selected from the group consisting of 1 type may be substituted), a benzothienyl C1-6 alkyl group (on the benzothiophene ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of alkoxy groups may be substituted), a phenyl C2-6 alkenyl group (on the phenyl ring, a halogen atom, a halogen atom). At least one selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), a benzofuryl C1-6 alkyl group ( On the benzofuran ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. Benzofuryl C2-6 alkenyl group (on the benzofuran ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one of which may be substituted), a thiazolyl C 1-6 alkyl group (on the thiazole ring, at least one phenyl Group [on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. May be substituted), a phenoxy C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of alkoxy groups may be substituted), an indolyl C1-6 alkyl group (on the indole ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group) And at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted) and phenyl C1-6a Kill group (on the phenyl ring, at least one selected from the group consisting of benzofuryl group, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group) And at least one group selected from the group consisting of: a group selected from the group consisting of: may be substituted) may be substituted);
(E) 1,2,3,4-tetrahydroquinolyloxy group (an oxo group on the 1,2,3,4-tetrahydroquinoline ring, a phenyl group [on the phenyl ring, a halogen atom, halogen substitution or At least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] and a phenyl C1-6 alkyl group [phenyl ring Above, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] At least one group selected from the group consisting of may be substituted);
(F) 1,2,3,4-tetrahydronaphthyloxy group (at least one oxo group may be substituted on the 1,2,3,4-tetrahydronaphthalene ring);
(G) 2H-chromenyloxyl group (at least one oxo group may be substituted on the 2H-chromene ring);
(H) a naphthyloxy group (at least one piperidyl group on the naphthalene ring [at least one phenoxy group on the piperidine ring (halogen atom, halogen-substituted or unsubstituted C 1- A group selected from the group consisting of a 6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) may be substituted]. );
(I) 1,2,3,4-tetrahydroisoquinolyloxy group (on 1,2,3,4-tetrahydroisoquinoline ring, C1-6 alkoxycarbonyl group, phenyl C1-6 alkyl group [on phenyl ring May be substituted with at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] and Phenyl group [on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. And at least one group selected from the group consisting of may be substituted);
(J) Group —NR ²² R ²³
(R ²² represents a hydrogen atom or a C 1-6 alkyl group. R ²³ represents (j-1) phenyl group [on the phenyl ring, at least one piperidyl group (on the piperidine ring, at least one A phenoxy group [on the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. May be substituted)], (j-2) phenyl C1-6 alkyl group [on the phenyl ring, piperidyl group (on the piperidine ring) A phenoxy group [on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is placed. May be substituted] and a group —NR ²⁴ R ²⁵ (R ²⁴ represents a hydrogen atom or a C 1-6 alkyl group. R ²⁵ represents a phenyl C 2-6 alkenyl group [ On the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. It is assumed that at least one group selected from the group consisting of: is substituted], (j-3) piperidyl C1-6 alkyl group [on the piperidine ring, at least one group selected from A phenyl group (on the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted; Have And (j-4) a thiazolyl group [on the thiazole ring, a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group) At least one group selected from the group consisting of a group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), piperazinyl C1-6 alkyl group (on the piperazine ring, at least one group) Of the phenyl group [on the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. Optionally substituted] and piperidyl C1-6 alkyl groups (on the piperidine ring at least one phenoxy group [on the phenyl ring, halo Or a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]. Or at least one group selected from the group consisting of: may be substituted] or (j-5) phenyl C2-6 alkenyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted At least one group selected from the group consisting of a substituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]. );
(K) a benzoxazolyloxy group (on the benzoxazole ring, a piperazinyl group [on the piperazine ring, a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1 6 alkyl groups and at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted) and phenyl C2-6 alkenyl groups (on the phenyl ring, halogen At least one selected from the group consisting of an atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted). At least one of the selected groups may be substituted], a piperidyl group [on the piperidine ring, a phenyl C1-6 alkyl group (Fe On the ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. And a C1-6 alkyl group and a phenyl group on the amino group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 A group selected from the group consisting of 6 alkoxy groups may be substituted], a group selected from the group consisting of at least one group may be substituted) At least one may be substituted] and a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1 At least one group selected from the group consisting of 6 alkoxy group at least one group selected from the group consisting of and may have) substitution assumed to substituted);
(L) Benzimidazolyloxy group (on the benzimidazole ring, a C1-6 alkyl group, a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted group) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted], piperidyl group [at least one phenoxy group on the piperidine ring (halogen atom on the phenyl ring, A halogen-substituted or unsubstituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted). A piperazinyl group [on the piperazine ring at least one phenyl C1-6 alkyl group (on the phenyl ring a halogen atom, halo Or a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted). And a phenyl C1-6 alkyl group [on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] At least one of the groups selected from the group consisting of: which may be substituted] may be substituted);
(M) 1,2,3,4-tetrahydroisoquinolyl group (on the 1,2,3,4-tetrahydroisoquinoline ring, (m-1) amino group [C1-6 alkyl on amino group] A group, a phenyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; Optionally substituted) and a phenyl C1-6 alkyl group (on the phenyl ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one group selected from the group consisting of a group selected from the group consisting of: (m-2) a phenoxy group [on the phenyl ring] The halo A group selected from the group consisting of a gen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]. At least one of the selected groups may be substituted);
(N) a piperidyl group (on the piperidine ring, (n-1) a phenyl group [on the phenyl ring, at least one group —NR ²⁶ R ²⁷ (R ²⁶ represents a hydrogen atom or a C 1-6 alkyl group) R ²⁷ represents a phenyl group [on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C 1-6 alkyl group, and a halogen-substituted or unsubstituted C 1-6 alkoxy group; At least one may be substituted.]) Is substituted], (n-2) group -W ₁ NR ²⁸ R ²⁹ [W ₁ represents a C 1-6 alkylene group. R ²⁸ represents a hydrogen atom or a C 1-6 alkyl group, and R ²⁹ represents a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C 1-6 alkyl group, and a halogen-substituted or unsubstituted C 1 Of a group selected from the group consisting of ˜6 alkoxy groups At least one kind may be substituted)], (n-3) a C1-6 alkoxy group substituted with two phenyl groups [on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1 -6 alkyl group and at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] and (n-4) phenyl C1-6 alkyl group [phenyl On the base ring, at least one phenyl group (on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one of the groups selected from the group consisting of] may be substituted).
(O) Piperazinyl group (on the piperazine ring, a C1-6 alkyl group substituted with two phenyl groups [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or non-substituted group) At least one group selected from the group consisting of substituted C1-6 alkoxy groups may be substituted], phenyl C1-6 alkyl group [on the phenyl ring, at least one phenoxy group (phenyl ring) Above, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. ) Is substituted], thiazolyl group [at least one phenyl group may be substituted on the thiazole ring], Nonoxy C1-6 alkyl group [on phenyl ring, phenyl group (on phenyl ring, consisting of halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group Selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. At least one of the groups may be substituted], a phenyl C2-6 alkenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group] And at least one group selected from the group consisting of C1-6 alkoxy groups is substituted] and imidazo [On the imidazole ring, it comprises at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] And at least one group selected from the group may be substituted) and may be substituted]. At least one group selected from the group consisting of:
(P) thiazolyl C1-6 alkoxy group (on the thiazole ring, (p-1) phenoxy C1-6 alkyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen At least one group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted], (p-2) anilino C1-6 alkyl group [on the phenyl ring, halogen At least one selected from the group consisting of an atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted], (p-3 ) Phenyl C1-6 alkyl group [on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] At least one of the groups may be substituted], (p-4) piperazinyl C1-6 alkyl group [on the piperazine ring at least one phenyl group (on the phenyl ring, halogen atom, halogen A group selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted)] And (p-5) a piperidyl C1-6 alkyl group [on the piperidine ring at least one phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or At least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted) and may be substituted] at least one group selected from the group consisting of There may be substituted);
(q) 8-azabicyclo [3.2.1] octyl group (at least one phenoxy group on the 8-azabicyclo [3.2.1] octane ring [halogen atom, halogen substitution on the phenyl ring] Or at least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted].
(r) group

[Wherein X represents a halogen atom or an amino-substituted C1-6 alkyl group which may have a C1-6 alkyl group as a substituent. m shows the integer of 0-3. R ³ represents any one of the following groups (i) to (xxii).
(i) Group- (W) o-NR ⁴ R ⁵
(W is, .R ⁴ .o is indicating 0 or 1 indicating the group -CO- or C1~6 alkylene group, a hydrogen atom, a C1~6 alkyl group or a phenylcarbamoyl group [on the phenyl ring, a halogen atom , .R ⁵ showing a may be at least one substituted group selected from the group consisting of C1~6 alkoxy group a halogen substituted or unsubstituted C1~6 alkyl group and halogen-substituted or unsubstituted] is Phenyl C1-6 alkoxycarbonyl group [on the phenyl ring, at least a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; 1 type may be substituted]; phenyl C2-6 alkenylcarbonyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1- At least one group selected from the group consisting of 6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted]; phenyl C2-6 alkenyl groups [on the phenyl ring, halogen At least one selected from the group consisting of an atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]; piperidyl C1-6 An alkyl group [consisting of at least one phenyl group on the piperidine ring (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group A group selected from the group may be substituted); a phenyl C1-6 alkyl group [on the phenyl ring] Is a group selected from the group consisting of at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group). Benzofuryl C1-6 alkyl group [on the benzofuran ring, at least one halogen-substituted or unsubstituted C1-6 alkyl group is assumed to be substituted]. May be substituted]; piperidylcarbonyl C1-6 alkyl group [on the piperidine ring at least one phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and At least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted) It may also be] or group

[R ⁶ is, Cl to 6 alkyl groups; On phenyl group (the phenyl ring, C1 -4 alkylenedioxy group, a cyano group, a nitro group, an amino group which may have a Cl to 6 alkyl groups as substituents, An amino-substituted sulfonyl group that may have a C1-6 alkyl group as a substituent, a C1-6 alkoxycarbonyl group, a C1-6 alkylthio group, a phenoxy group, a phenyl C1-6 alkoxy group, a pyrrolidinyl group [on the pyrrolidine ring, At least one oxo group may be substituted], an imidazolyl group, an isoxazolyl group, an oxazolyl group, a phenyl C1-6 alkyl group, a phenyl group, an amino C1 to C1-6 alkyl group which may have a C1-6 alkyl group as a substituent 6 alkyl group, pyrrolidinyl C1-6 alkoxy group, halogen atom, halogen-substituted or unsubstituted C -6 alkyl group and at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted); phenyl C1-6 alkoxycarbonyl group (on the phenyl ring) , A halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted); 6 alkyl group (on the benzofuran ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. Benzofuryl C2-6 alkenyl group (on the benzofuran ring, halogen atom, halogen substitution) Or at least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted); a phenoxy C1-6 alkyl group (phenyl On the ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) A thiazolyl C1-6 alkyl group (on the thiazole ring, at least one phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of alkoxy groups may be substituted] may be substituted); -6 alkyl group (on the phenyl ring, from the group consisting of a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group A group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. At least one of them may be substituted); a pyridyl C1-6 alkyl group (on the pyridine ring, at least one phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1- A group selected from the group consisting of 6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted] C1-6 alkoxycarbonyl group; benzoyl group (on the phenyl ring, from halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group) And at least one group selected from the group may be substituted); a phenylcarbamoyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted); a benzothienyl group; a benzothienyl C1-6 alkyl group (on the benzothiophene ring at least one halogen); An indolyl C1-6 alkyl group (on the indole ring, the halogen atom may be substituted) 4H-1, at least one group selected from the group consisting of a group selected from the group consisting of a C 1-6 alkyl group and a halogen-substituted or unsubstituted C 1-6 alkyl group and a halogen-substituted or unsubstituted C 1-6 alkoxy group); 3-benzodioxinyl group (at least one halogen atom may be substituted on the 4H-1,3-benzodioxine ring); naphthyl group; quinolyl group; benzothiazolyl group (on benzothiazole ring) May be substituted with at least one C1-6 alkyl group); 2,3-dihydro-1H-indenyl group (on the 2,3-dihydro-1H-indane ring, at least one oxo Group may be substituted); 9H-fluorenyl group or phenyl C2-6 alkenyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group) And at least one group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted. ]
Indicates. );
(ii) Group

(W and o are the same as described above. The dotted line may indicate a double bond. When the dotted line indicates a double bond, only R ⁸ is substituted. R ⁷ is a hydrogen atom, hydroxyl, [on the phenyl ring, halogen may be substituted] Cl to 6 alkoxy group or a phenyl group .R ⁸ showing a indicates one of the following groups (1) to (63).
(1) Phenyl C1-6 alkoxy substituted C1-6 alkyl group (on the phenyl ring, C1-4 alkylenedioxy group, halogen atom, cyano group, phenyl group, phenyl C1-6 alkoxy group, phenyl C2-6 alkenyl) At least one group selected from the group consisting of a group, a phenoxy group, a C1-6 alkylthio group, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. May be);
(2) Phenyl C1-6 alkoxy group (on the phenyl ring, cyano group, phenyl group, C1-6 alkoxycarbonyl group, phenoxy group, C1-6 alkylthio group, halogen atom, halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of an alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted);
(3) Phenyl C2-6 alkenyloxy group (on the phenyl ring, selected from the group consisting of halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups) At least one of the groups may be substituted);
(4) Group-(W) o-NR ⁹ R ¹⁰
(W and o are the same as above.
R ⁹ and R ¹⁰ are the same or different and are a hydrogen atom; a C 1-6 alkyl group which may have a hydroxyl group as a substituent; a C 1-6 alkanoyl group; a C 1-6 alkoxycarbonyl group; a phenyl C 1-6 alkoxycarbonyl group. [At least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted on the phenyl ring. A phenyl group [on the phenyl ring, a halogen atom as a substituent, a halogen-substituted or unsubstituted C1-6 alkyl group, a halogen-substituted or unsubstituted C1-6 alkoxy group, a C1-6 alkanoyl as a substituent] An amino group which may have a group selected from the group consisting of a group and a C1-6 alkyl group, a C1-6 alkoxycarbonyl group Phenyl group, phenoxy group (on the phenyl ring, at least one kind selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) May be substituted), an aminosulfonyl group, 1,2,3,4-tetrahydroquinolyl group (on the 1,2,3,4-tetrahydroquinoline ring, at least one oxo group as a substituent) Optionally substituted), C1-6 alkylsulfonyl group, C3-8 cycloalkyl group, nitro group, cyano group, C1-6 alkylthio group, phenylsulfonyl group (on the phenyl ring, halogen atom, halogen substituted or At least one selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. Group), hydroxyl-substituted C1-6 alkyl groups and groups

(W ₁ represents a C 1-6 alkylene group. R ¹¹ and R ¹² are the same or different and represent a C 1-6 alkoxy group) and at least one group selected from the group consisting of is substituted. Phenyl C1-6 alkyl group [on the phenyl ring, a C1-4 alkylenedioxy group as a substituent, a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl] A group selected from the group consisting of a group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), a group —N (R ^11A ) R ^12A (R ^11A and R ^12A are R ^11A and R ^12A are the same or different and each represents a hydrogen atom, a C 1-6 alkyl group or a phenyl group, and R ^11A and R ^12A are bonded together with or without a nitrogen atom, oxygen atom or sulfur atom together with an adjacent nitrogen atom. A 5- to 7-membered saturated heterocyclic ring), a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6) At least one group selected from the group consisting of alkoxy groups may be substituted), phenyl C1-6 alkoxy groups, amino group-substituted C1-6 alkoxys that may have C1-6 alkyl groups as substituents A group, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a group selected from the group consisting of a halogen-substituted or unsubstituted C1-10 alkoxy group may be substituted]; benzofuryl C1-6 alkyl group [on the benzofuran ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1 At least one group selected from the group consisting of 6 alkoxy groups may be substituted]; phenylsulfonyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, halogen] At least one group selected from the group consisting of a substituted or unsubstituted C1-6 alkoxy group and a C1-4 alkylenedioxy group may be substituted]; a phenoxycarbonyl group [on the phenyl ring, a halogen At least one selected from the group consisting of an atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]; phenyl C2-6 Alkenyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of alkoxy groups may be substituted]; C1-6 alkoxy substituted C1-6 alkyl groups; C2-6 alkenyl groups; C1-6 alkoxy substituted C2-6 alkanoyl groups C3-8 cycloalkyl-substituted C1-6 alkyl group; phenoxy C1-6 alkyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6; At least one group selected from the group consisting of alkoxy groups may be substituted]; a benzoyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or At least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted]; phenylcarbamoy [On the phenyl ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. A pyridyl group; a pyridyl C1-6 alkyl group; an imidazolyl C1-6 alkyl group; a 1,2,3,4-tetrahydroquinolyl group [1,2,3,4-tetrahydroquinoline ring; And at least one group selected from the group consisting of an oxo group and a C1-6 alkyl group may be substituted as a substituent]; a quinolyl group; an indolyl group; a C1-6 alkyl group as a substituent Indazolyl group; naphthyl group; C3-8 cycloalkyl group; amino-substituted C1-6 alkyl which may have a C1-6 alkyl group as a substituent Group; cyano-substituted C1~6 alkyl group; furyl substituted C1~6 alkyl group; group

[RR represents a phenyl group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. Species may be substituted). Or a piperazinyl-substituted C1-6 alkyl group [on the piperazine ring at least one phenyl group as a substituent (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or And at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted)].
R ⁹ and R ¹⁰ together with the adjacent nitrogen atom are bonded to each other through or without a nitrogen atom, an oxygen atom or a sulfur atom to form a 1,2,3,4-tetrahydroisoquinolyl group, an isoindolyl group or a 5- A 7-membered saturated heterocyclic ring may be formed. On the heterocyclic ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, a halogen-substituted or unsubstituted C1-6 alkoxy group, a phenyl group [on the phenyl ring, a phenyl group, a halogen atom, a halogen At least one group selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted], a benzoyl group [on the phenyl ring May be substituted with at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group], pyridyl C1-6 alkyl group, C3-8 cycloalkyl group, phenyl C1-6 alkyl group [on the phenyl ring, C1-4 alkylenedioxy group, halogen At least one selected from the group consisting of an atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted], piperidyl C1-6 Alkyl group, piperidyl group, phenyl C1-6 alkoxy group [on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] At least one of the selected groups may be substituted], a phenoxy group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy At least one group selected from the group consisting of groups may be substituted], a phenyl group as a substituent [on the phenyl ring, A group selected from the group consisting of a gen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group] may be substituted], C1-6 An alkyl group and a phenyl C1-6 alkyl group [on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group; At least one of the groups selected from the group consisting of: an amino group, a benzoxazolyl group, a phenyl C2-6 alkenyl group (on the phenyl ring) Is a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group And at least one group selected from the group consisting of benzoimidazolyl groups may be substituted).
(5) a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1 A group selected from the group consisting of -6 alkoxy groups may be substituted), a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one group selected from the group may be substituted);
(6) Carbamoyloxy group (on the amino group, a C1-6 alkyl group and a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1 At least one group selected from the group consisting of ˜6 alkoxy groups may be substituted], at least one group selected from the group consisting of may be substituted);
(7) Carbamoyloxy-substituted C1-6 alkyl group (on the amino group, a C1-6 alkyl group, a phenyl C1-6 alkyl group, a C3-8 cycloalkyl group, a naphthyl group, 2,3-dihydro-1H-indenyl Group, 2,3-dihydrobenzofuryl group and phenyl group [on the phenyl ring, C1-4 alkylenedioxy group, cyano group, phenoxy group, C1-6 alkylthio group, C1-6 alkanoyl group, phenyl group, phenyl group Even if at least one group selected from the group consisting of a C1-6 alkyl group, a halogen atom, a halogen-substituted or unsubstituted C1-10 alkyl group and a halogen-substituted or unsubstituted C1-10 alkoxy group is substituted At least one group selected from the group consisting of:
(8) Phenoxy C1-6 alkyl group (on the phenyl ring, halogen atom; C1-4 alkylenedioxy group; C1-6 alkoxycarbonyl group; phenyl group; phenoxy group; pyrrolyl group; benzothiazolyl group; 1,2, 4-triazolyl group; imidazolyl group; isoxazolyl group; benzoxazolyl group; benzotriazolyl group; cyano group; nitro group; C2-6 alkanoyl group; C1-6 alkanoyl group; An alkyl group; a C1-6 alkanoyl-substituted C1-6 alkyl group; a group -N ( ^R11B ) ^R12B ( ^R11B and ^R12B may be the same or different and each represents a hydrogen atom, a C1-6 alkyl group, a C1-6 alkanoyl group, or .R ^11B and R ^12B represents a phenyl group, together with the adjacent nitrogen atom, via a nitrogen atom, an oxygen atom or a sulfur atom May form a 5- to 7-membered saturated heterocyclic ring without any intervening, on which a C1-6 alkoxycarbonyl group and an amino group [on the amino group, a phenyl group (phenyl On the ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. And at least one group selected from the group consisting of C1-6 alkyl groups may be substituted], at least one group selected from the group consisting of may be substituted); phenyl C1 -6 alkoxy group; phenyl C1-6 alkyl group; C1-6 alkylthio group; C3-8 cycloalkyl group; halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1~10 at least one group selected from the group consisting of alkoxy group which may be substituted);
(9) tetrahydropyranyloxy C1-6 alkyl group;
(10) hydroxyl group-substituted C1-6 alkyl group;
(11) Furyl C1-6 alkoxy-substituted C1-6 alkyl group (on the furan ring, at least one C1-6 alkoxycarbonyl group may be substituted);
(12) tetrazolyl C1-6 alkoxy-substituted C1-6 alkyl group (on the tetrazole ring, phenyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted), a phenyl C1-6 alkyl group and a C3-8 cycloalkyl C1-6 alkyl group. Group may be substituted);
(13) isoxazolyl C1-6 alkoxy-substituted C1-6 alkyl group (on the isoxazole ring, at least one C1-6 alkyl group may be substituted);
(14) A benzothienyl C1-6 alkoxy-substituted C1-6 alkyl group (on the benzothiophene ring, from a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one group selected from the group consisting of may be substituted);
(15) 1,3,4-oxadiazolyl C1-6 alkoxy-substituted C1-6 alkyl group (on the 1,3,4-oxadiazole ring, phenyl group [on the phenyl ring, halogen atom, halogen-substituted or At least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] may be substituted);
(16) a C2-6 alkynyloxy substituted C1-6 alkyl group;
(17) Naphthyl C1-6 alkoxy substituted C1-6 alkyl group;
(18) 1,2,4-oxadiazolyl C1-6 alkoxy-substituted C1-6 alkyl group [on the 1,2,4-oxadiazole ring, a phenyl group may be substituted];
(19) Pyridyl C1-6 alkoxy-substituted C1-6 alkyl group [on the pyridine ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one of the more selected groups may be substituted];
(20) thiazolyl C1-6 alkoxy-substituted C1-6 alkyl group [on thiazole ring, phenyl group (on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted And at least one group selected from the group consisting of C1-6 alkoxy groups may be substituted) and at least one group selected from the group consisting of C1-6 alkyl groups may be substituted. ];
(21) 1,2,3,4-tetrahydronaphthyl C1-6 alkoxy-substituted C1-6 alkyl group [the 1,2,3,4-tetrahydronaphthalene ring is substituted with at least one C1-6 alkyl group You may do it];
(22) Carbamoyl C1-6 alkoxy-substituted C1-6 alkyl group [on the amino group a C3-8 cycloalkyl group and a phenyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 alkyl And at least one group selected from the group consisting of a group selected from the group consisting of a group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) Good];
(23) A benzofuryl C1-6 alkoxy-substituted C1-6 alkyl group [on the benzofuran ring, at least one cyano group may be substituted];
(24) Benzofuryl C1-6 alkyl group [on the benzofuran ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one of them may be substituted];
(25) Phenoxy group [on the phenyl ring, at least one group selected from the group consisting of a phenyl C1-6 alkoxy group, a C3-8 cycloalkyl group, a C7-10 alkoxy group, and a phenoxy group is substituted. Shall be]];
(26) naphthyloxy group ;
(31) quinolyloxy group;
(32) Furyl C1-6 alkoxy group [on the furan ring, at least one C1-6 alkoxycarbonyl group may be substituted];
(33) tetrazolyl C1-6 alkoxy group [on the tetrazole ring, at least one group selected from the group consisting of a phenyl C1-6 alkyl group and a C3-8 cycloalkyl C1-6 alkyl group is substituted. Good];
(34) 1,2,4-oxadiazolyl C1-6 alkoxy group [on the 1,2,4-oxadiazole ring, a phenyl group (on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6 A group selected from the group consisting of a 6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted) may be substituted];
(35) benzothienyl C1-6 alkoxy group [on the benzothiophene ring, at least one halogen atom may be substituted];
(36) isoxazolyl C1-6 alkoxy group [at least one C1-6 alkyl group may be substituted on the isoxazole ring];
(37) 1,3,4-oxadiazolyl C1-6 alkoxy group [on the 1,3,4-oxadiazole ring, at least one phenyl group (on the phenyl ring, at least one C1-6 An alkyl group may be substituted) may be substituted];
(38) Naphthyl C1-6 alkoxy group;
(39) Pyridyl C1-6 alkoxy group (at least one halogen-substituted or unsubstituted C1-6 alkyl group may be substituted on the pyridine ring);
(40) thiazolyl C1-6 alkoxy group [on the thiazole ring, at least one phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group) At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted) may be substituted];
(41) 1,2,3,4-tetrahydronaphthyl C1-6 alkoxy group (on the 1,2,3,4-tetrahydronaphthalene ring, at least one C1-6 alkyl group may be substituted) );
(42) a phenoxy C1-6 alkoxy group (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one of them may be substituted);
(43) Carbamoyl C1-6 alkoxy group [on the amino group, a C3-8 cycloalkyl group and a phenyl group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or At least one group selected from the group consisting of a group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted];
(44) A benzofuryl C1-6 alkoxy group (on the benzofuran ring, at least one cyano group may be substituted);
(45) Naphtyloxy C1-6 alkyl group (on the naphthalene ring, at least one C1-6 alkoxy group may be substituted);
(46) benzothiazolyloxy C1-6 alkyl group (on the benzothiazole ring, at least one C1-6 alkyl group may be substituted);
(47) Quinolyloxy C1-6 alkyl group (on the quinoline ring, at least one C1-6 alkyl group may be substituted);
(48) 2,3-dihydrobenzofuryloxy C1-6 alkyl group (on the 2,3-dihydrobenzofuran ring, at least one group selected from the group consisting of a C1-6 alkyl group and an oxo group is substituted) You may)
(49) 1,2,3,4-tetrahydronaphthyloxy C1-6 alkyl group (on the 1,2,3,4-tetrahydronaphthalene ring, at least one oxo group may be substituted);
(50) 2,3-dihydro-1H-indenyloxy C1-6 alkyl group (at least one oxo group may be substituted on the 2,3-dihydro-1H-indene ring);
(51) a benzooxathiolanyloxy C1-6 alkyl group (on the benzooxathiolane ring, at least one oxo group may be substituted);
(52) Isoquinolyloxy C1-6 alkyl group;
(53) pyridyloxy C1-6 alkyl group;
(54) dibenzofuryloxy C1-6 alkyl group;
(55) 2H-1-benzopyranyloxy C1-6 alkyl group (on the 2H-1-benzopyran ring, at least one oxo group may be substituted);
(56) benzoisoxazolyloxy C1-6 alkyl group;
(57) Benzofurazanyloxy C1-6 alkyl group;
(58) Quinoxalyloxy C1-6 alkyl group;
(59) C1-6 alkoxy C1-6 alkoxy substituted C1-6 alkyl group;
(60) thienyl C1-6 alkoxy-substituted C1-6 alkyl group (on the thiophene ring, at least one halogen atom may be substituted);
(61) Phenyl C2-6 alkenyloxy-substituted C1-6 alkyl group (on the phenyl ring, consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one group selected from the group may be substituted);
(62) quinolyl C1-6 alkoxy substituted C1-6 alkyl group;
(63) piperidylcarbonyl C1-6 alkoxy substituted C1-6 alkyl group;
R ⁷ and R ⁸ may be taken together to form the group ═C (R ²⁹ ) (R ³⁰ ). Here, R ²⁹ and R ³⁰ are the same or different and each represents a hydrogen atom, a C1-6 alkyl group or a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or And at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted]. );
(iii) group

(W ₁ and o are the same as above. R ¹³ is 2,3-dihydro-1H-indenyl group; benzothienyl group; phenyl C 2-10 alkenyl group [on the phenyl ring, a halogen atom, C 1-4 alkylene diene] An oxy group, a C1-6 alkylthio group, a benzoyl group, a cyano group, a nitro group, a C2-6 alkanoyloxy group, an amino group that may have a C1-6 alkyl group as a substituent, a hydroxyl group, a phenyl C1-6 alkoxy group, At least one group selected from the group consisting of a phenoxy group, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]; 6 alkenyl group; benzofuryl C1-6 alkyl group [on the benzofuran ring, halogen atom, halogen-substituted or not At least one group selected from the group consisting of a C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]; a benzothienyl C2-6 alkenyl group; a benzothiazolyl C2- 6 alkenyl group [at least one C1-6 alkyl group may be substituted on the benzothiazole ring]; phenyl C1-6 alkyl group [on the phenyl ring, piperidinyl group (on the piperidine ring) At least one phenoxy group [on the phenyl ring, at least a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; May be substituted], a phenyl group (on the phenyl ring, a halogen atom, a halogen It is assumed that at least one group selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted, and a phenoxy group (on the phenyl ring) May be substituted with at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group). A diphenyl C1-6 alkyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen] At least one group selected from the group consisting of substituted or unsubstituted C1-6 alkoxy groups may be substituted]; C1-6 alkyl group [on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group. There assumed to be substituted]; Cl to 6 alkyl groups, the Cl to 6 alkoxycarbonyl group and a phenyl Cl to 6 alkyl group [on the phenyl ring, on the phenyl group (the phenyl ring, a halogen atom, halogen-substituted Or at least one group selected from the group consisting of an unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted), a halogen atom, a halogen-substituted or unsubstituted A small number of groups selected from the group consisting of C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups. At least one group selected from the group consisting of at least one kind may be substituted] an amino group which may be substituted; a C1-6 alkyl group and a phenyl group (on the phenyl ring, a halogen atom; , At least one group selected from the group consisting of a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted). An amino C1-6 alkyl group optionally substituted by at least one group; a benzofuryl C2-6 alkenyl group [on the benzofuran ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or At least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted]; piperidyl group [on the piperidine ring Includes at least one phenyl C2-6 alkenyl group (on the phenyl ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group). At least one of the selected groups may be substituted)]; a ferrocene-substituted C1-6 alkyl group, an indolyl C1-6 alkyl group (on the indole ring, at least one A halogen atom may be substituted); a phenyl C2-6 alkynyl group; a phenyl group [on the phenyl ring, a C1-4 alkylenedioxy group, a phenyl group, a C1-6 alkoxycarbonyl group, a hydroxyl group and a phenoxy group ( On the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1 And at least one group selected from the group consisting of a group selected from the group consisting of ˜6 alkoxy groups may be substituted); a benzofuryl group [benzofuran On the ring, at least one group selected from the group consisting of a halogen atom and a C1-6 alkyl group may be substituted]; a benzothiazolinyl group [at least one group on the benzothiazoline ring] An oxo group may be substituted]; a benzothienyl group [at least one halogen atom may be substituted on the benzothiophene ring]; a naphthyl group; 1,2,3,4-tetrahydro Quinolyl group [On the 1,2,3,4-tetrahydroquinoline ring, at least one group selected from the group consisting of an oxo group and a C1-6 alkyl group may be substituted] Benzoisoxazolyl group; 2,3-dihydrobenzofuryl group; 1,2-dihydrohydroquinolyl group [at least one oxo group may be substituted on the 1,2-dihydroquinoline ring] A 1,2,3,4-tetrahydroquinazolinyl group [on the 1,2,3,4-tetrahydroquinazoline ring, at least one group selected from the group consisting of an oxo group and a C1-6 alkyl group; May be substituted]; benzocycloheptyl group; phenoxy C1-6 alkyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 At least one group selected from the group consisting of 6 alkoxy groups may be substituted]; a benzothienyl-substituted C1-6 alkyl group [on the benzothiophene ring] May have at least one halogen atom]; a naphthyl-substituted C1-6 alkyl group [at least one C1-6 alkoxy group may be substituted on the naphthalene ring]; A pyridyl-substituted C1-6 alkyl group [at least one halogen atom may be substituted on the pyridine ring]; a furyl-substituted C1-6 alkyl group [at least one nitro group on the furan ring; May be substituted]; a thienyl substituted C1-6 alkyl group [at least one halogen atom may be substituted on the thiophene ring]; a thiazolyl substituted C1-6 alkyl group [on the thiazole ring A C1-6 alkyl group and a phenyl group (on the phenyl ring, a small number of groups selected from the group consisting of halogen atoms and halogen-substituted or unsubstituted C1-6 alkyl groups). At least one group selected from the group consisting of 1 may be substituted); a tetrazolyl-substituted C1-6 alkyl group [on the tetrazole ring, at least one group C1-6 alkyl group may be substituted]; isoxazolyl-substituted C1-6 alkyl group [on the isoxazole ring, at least one C1-6 alkyl group may be substituted]; , 4-Oxadiazolyl-substituted C1-6 alkyl group [At least one phenyl group on the 1,2,4-oxadiazole ring (even if a C1-6 alkyl group is substituted on the phenyl ring) May be substituted)] or a benzofurazanyl-substituted C1-6 alkyl group. );
(iv) Group

(R ¹⁴ is a phenylamino group [wherein the N-position of the phenylamino group may be substituted with a C1-6 alkyl group, and on the phenyl ring of the phenylamino group, at least one halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted]; piperidyl group [phenoxy group on the piperidine ring (halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted on the phenyl ring. ) And an amino group (on the amino group, a C1-6 alkyl group and a phenyl group as a substituent [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted group) And at least one group selected from the group consisting of C1-6 alkoxy groups may be substituted]. And at least one group selected from the group consisting of: a piperazinyl group [on the piperazine ring, a C1-6 alkoxycarbonyl group, a phenyl C1-6 alkyl group ( On the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. A phenyl C2-6 alkenyl group (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) At least one of them may be substituted) and a benzoyl group (on the phenyl ring, a halogen atom, halogen-substituted or At least one group selected from the group consisting of a substituted C1-6 alkyl group and a group selected from the group consisting of halogen-substituted or unsubstituted C1-6 alkoxy groups). A seed may be substituted]; a phenyl group (on the phenyl ring, selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) A homopiperazinyl group [on the homopiperazine ring, a C1-6 alkoxycarbonyl group and a phenyl C1-6 alkyl group (on the phenyl ring, a halogen atom, a halogen atom] A group selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one group selected from the group consisting of optionally substituted) or a phenoxy group [on the phenyl ring, halogen-substituted or unsubstituted C1-6. At least one group selected from the group consisting of an alkoxy group and a phenoxy-substituted phenyl group (at least one halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted on the phenyl ring); It may be substituted]. );
(v) Base

(R ¹³ is the same as above. The dotted line indicates that it may be a double bond.);
(vi) Homopiperazinyl group (C1-6 alkoxycarbonyl group on homopiperazine ring; phenyl C1-6 alkyl group [on the phenyl ring, halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted) Alternatively, at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted]; a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1- At least one group selected from the group consisting of 6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups may be substituted]; a phenyl C1-6 alkoxycarbonyl group [on the phenyl ring, Halogen atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 atoms At least one group selected from the group consisting of alkoxy groups may be substituted]; phenylcarbamoyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted group] Or at least one group selected from the group consisting of unsubstituted C1-6 alkoxy groups may be substituted]; phenyl C2-6 alkenyl groups [on the phenyl ring, halogen atoms, halogen substituted or unsubstituted At least one group selected from the group consisting of a substituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted] and a benzoyl group [on the phenyl ring, From atoms, halogen-substituted or unsubstituted C1-6 alkyl groups and halogen-substituted or unsubstituted C1-6 alkoxy groups That at least one group of at least one kind selected from the group consisting of] may be substituted groups may be substituted selected from a group);
(vii) group

(Wherein, R ¹⁹ is .R ²⁰ showing a C1~6 alkoxy group, on the phenyl group [the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1~6 alkyl group and halogen-substituted or unsubstituted And at least one group selected from the group consisting of C1-6 alkoxy groups may be substituted].
(viii) group —CHR ²⁰ R ²¹
(R ²⁰ is the same as described above. R ²¹ represents an amino group which may have a C1-6 alkyl group as a substituent.);
(ix) 1,2,3,4-tetrahydroisoquinolyl group (at least one amino group on the 1,2,3,4-tetrahydroisoquinoline ring [phenyl C1-6 alkyl on the amino group) Group (on the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted. And at least one group selected from the group consisting of C1-6 alkyl groups may be substituted] may be substituted);
(x) an oxazolyl group (on the oxazole ring, a phenyl group [on the phenyl ring, a group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one of the selected groups may be substituted], a C1-6 alkyl group and a piperidyl group [on the piperidine ring at least one phenoxy group (on the phenyl ring, a halogen atom, a halogen At least one group selected from the group consisting of a substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted but may be substituted). At least one group selected from the group of which may be substituted] may be substituted);
(xi) Isoindolinyl group (on the isoindoline ring, at least one selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group, and a halogen-substituted or unsubstituted C1-6 alkoxy group) May be substituted);
(xii) thiazolyl group (phenoxy C1-6 alkyl group on thiazole ring [halogen atom, halogen-substituted or unsubstituted C1-6 alkyl group and halogen-substituted or unsubstituted C1-6 alkoxy group on phenyl ring) At least one group selected from the group consisting of may be substituted]; a phenyl group [on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted group; At least one group selected from the group consisting of C1-6 alkoxy groups may be substituted]; phenyl C1-6 alkyl group [on the phenyl ring, a halogen atom, halogen-substituted or unsubstituted C1-6; At least one selected from the group consisting of an alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group is substituted May be]; group ^{_{- (W 1) oNR 31 R}} 32 [W 1 and o are as defined above .R ³¹ and R ³² are the same or different, a hydrogen atom, Cl to 6 alkyl group, a phenyl group (On the phenyl ring, at least one group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted. Or a phenyl C1-6 alkyl group (on the phenyl ring, a group selected from the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group) A piperazinyl group [on the piperazine ring at least one phenyl group (on the phenyl ring, a halogen atom, A group selected from the group consisting of a rogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group may be substituted)] A piperidyl group [on the piperidine ring is selected from the group consisting of a phenoxy group (on the phenyl ring, a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group; And at least one group selected from the group consisting of phenyl C1-6 alkyl groups may be substituted] and a phenoxy group [on the phenyl ring, From the group consisting of a halogen atom, a halogen-substituted or unsubstituted C1-6 alkyl group and a halogen-substituted or unsubstituted C1-6 alkoxy group At least one group of at least one kind selected from the group consisting of] may be substituted groups may be substituted selected)
2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compounds represented by the formula, optically active isomers thereof or pharmacologically acceptable salts thereof. The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound is
2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylbenzyloxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole ,
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylbenzyloxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1 -B] oxazole,
(R) -2-Methyl-6-nitro-2- {4- [4- (4-chlorophenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] Oxazole,
(R) -6-nitro-2- {4- [4- (4-trifluoromethoxybenzyloxy) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -2-Methyl-6-nitro-2- [4- {4- [4- (4-trifluoromethylphenyl) piperazin-1-yl] piperidin-1-yl} phenoxymethyl] -2,3 -Dihydroimidazo [2,1-b] oxazole,
2-methyl -6-nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethoxybenzyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b ] Oxazole,
(R) -6-nitro-2- [4- {4- [3- (4-trifluoromethoxyphenyl) propyl] piperidin-1-yl} phenoxymethyl] -2,3-dihydroimidazo [2,1- b] oxazole,
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1- b] oxazole,
(R) -6-nitro- 2- {4- [4- (4-chlorophenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole,
(R) -6-nitro-2- {4- [4- (4-trifluoromethylphenoxymethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1-b] oxazole;
(R) -2-Methyl-6-nitro-2- {4- [4- (5-trifluoromethylbenzofuran-2-ylmethyl) piperidin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2 , 1-b] oxazole,
(R) -2-Methyl-6-nitro-2- {4- [4- (4-trifluoromethylcinnamyl) piperazin-1-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1- b] oxazole,
(R) -2-Methyl -6-nitro-2- [4- {4- [4- (4-trifluoromethoxyphenoxy) benzyl] piperazin-1-yl} phenoxymethyl] -2,3-dihydroimidazo [ 2,1-b] oxazole,
Or (R) -2-methyl-6-nitro-2- {4- [2- (4-trifluoromethoxyphenyl) oxazol-4-yl] phenoxymethyl} -2,3-dihydroimidazo [2,1- b] The 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound according to claim 1, which is oxazole, an optically active form thereof, or a pharmaceutically acceptable salt thereof.