JP4754303B2 - Wrinkle improvement beauty method - Google Patents

Description

  The present invention relates to a cosmetic method for improving wrinkles, and more particularly, to a cosmetic method for improving wrinkles using a weak current and a highly occlusive oily skin external preparation.

  The growing interest in beauty among middle-aged and older women has increased interest in fine wrinkles that appear in the corners of the eyes and mouth, which are manifested by a decrease in the water retention capacity of the epidermal stratum corneum with age and a decrease in sebum due to decreased secretion of epidermal lipids. .

  In order to prevent or improve wrinkles, skin care preparations containing various drugs and moisturizers have been developed. For example, preparations containing drugs such as vitamin C derivatives, vitamin A or derivatives thereof, and preparations containing moisturizing agents such as glycerin, sorbitol, and plant fluid extracts, collagen, and the like are known. However, these skin care cosmetics are very expensive, and need to be used for a certain period of time in order to bring about the effect of improving fine lines. Therefore, a beauty method that can effectively improve wrinkles, particularly fine lines, in a shorter period of time has been strongly desired.

  In recent years, various attempts using a weak current have been made in the fields of beauty formation and medicine. A weak current (biological current) of 100 μA to 200 μA originally flows in the human body, and this weak current contributes to the generation of ATP, protein synthesis, etc., and various growth, metabolism, cell division, etc. Has the function of promoting various physiological functions. For example, in the beauty industry, a cosmetic method for improving skin skin care, swelling, sagging, spots, wrinkles and the like by activating skin cells by directly applying a weak current to the skin has been implemented.

  In addition, there are various weak current devices used for such weak current therapy, from large ones used in specialty stores such as esthetic salons to handy-type relatively small devices sold as home care beauty devices. Various types are commercially available. Furthermore, in recent years, as a device that can easily and easily apply a weak current to the skin, there is a patch sheet that incorporates a 3V battery and is attached to the skin via a hydrogel (see, for example, Patent Documents 1 and 2), which is necessary. A weak current can be applied by simply sticking it to the skin for a long time, and it is expected to be applied especially for cosmetic use at home.

However, the wrinkle improvement using such a weak current is effective immediately after the treatment, but there is a problem that the duration of the wrinkle improvement effect is very short.
Japanese translation of PCT publication No. 2002-504836 JP 2000-502206 JP

  In view of the circumstances as described above, the present invention enhances the persistence of the wrinkle improvement effect by a weak current, and can effectively improve wrinkles in a short period of time without the need to use expensive drugs or moisturizing agents. Is intended to provide.

  When the present inventor gives a weak current to the skin, the moisture content of the skin is temporarily increased by forced water retention in the skin on the positive pole side, and the transient increase in the moisture content can contribute to wrinkle improvement. Furthermore, by applying a highly occlusive oily skin external preparation over the skin whose water content has increased by such a weak current, the moisture is retained on the skin surface for a long period of time, and the effect of wrinkle improvement is improved. The inventors have found that the sustainability can be improved, and have achieved the present invention.

  Forced water retention in the skin on the positive electrode side is an electroosmotic flow due to the flow of water from the positive electrode to the negative electrode that occurs when the cation adsorbed on the negatively charged stratum corneum is attracted to the negative electrode ( Electro-osmosis) is considered to be one of the factors. FIG. 1 outlines the mechanism of forced water retention at the positive pole that occurs when a weak current is applied.

  According to the wrinkle improving cosmetic method of the present invention, after applying a weak current to the skin, an oily skin external preparation containing 50% by mass or more of a semisolid oily base material at room temperature and having an occlusive property of 50% or more is applied to the skin. It is characterized by being applied to.

In the present specification, the “weak current” means a weak current at a level of 0.001 to 0.5 mA / cm ^{2 that} is normally applied to the skin for cosmetic purposes.

In the present specification, the term “occlusive” means that a sample is applied to a human forearm internal site (2.5 mg / cm ² ), and the transdermal moisture transpiration (TEWL) after 1 hour is measured with a moisture transpiration meter. Means the value calculated by the following formula:
Occlusion (%) = (1-TEWL (sample application) / TEWL (no sample)) × 100

  The oily base preferably contains petrolatum from the viewpoint of occlusive properties. By blending petrolatum, higher occlusive properties can be provided.

  Furthermore, from the viewpoint of usability, the oily skin external preparation preferably contains 5 to 50% by mass of powder. By blending such an amount of powder, it is possible to reduce stickiness and shine in oil-based bases with high occlusive properties such as petrolatum without reducing the occlusive properties, thereby improving usability.

  Moreover, it is preferable to apply the wrinkle-improving cosmetic method of the present invention to the skin of the corners of the eyes, the lower eyelid, or the mouth, which are actually sites where fine lines are easily formed.

  In the cosmetic method of the present invention, after the stratum corneum moisture content is increased by forced water retention by a weak current, a skin external preparation having high occlusive properties is applied thereon, so that the moisture collected by the weak current is applied to the skin surface for a long time. It can be held for a period of time and the skin can be kept in a full state for a long time. Therefore, fine lines can be effectively improved in a short period of time without the need to use expensive drugs or humectants.

  In the present invention, any method commonly used for cosmetic purposes or iontophoresis can be used as a method for applying a weak current to the skin, a device used, a voltage application condition, and the like. For example, a platinum, carbon, silver, zinc, manganese oxide, silver chloride electrode or the like can be used as the electrode, and the energization method may be any method such as a direct type, a pulse type, or a pulse depolarization type.

The current density was 0.001~0.5mA / cm ^2, more preferably 0.002~0.1mA / cm ^2.

  The time for applying the weak current is not particularly limited, but is usually 0.5 to 120 minutes, more preferably 1 to 60 minutes.

  Since a weak current can be applied to the skin more easily and simply, it is preferable to use a sheet-type micro battery embedded in a patch sheet in the present invention. For example, a patch sheet incorporating a 3V battery can be applied to the skin simply by applying it to the skin via a hydrogel covering the electrode, and the treatment can be easily stopped by peeling it off.

  If necessary, a skin lotion, essence, or the like containing a humectant or an arbitrary agent may be applied to the skin before applying a weak current to the skin. Alternatively, when a sheet-type microbattery is used, a hydrogel that contacts the skin may contain a moisturizing agent such as glycerin or any other agent that has an effect on wrinkle improvement.

  The oily skin external preparation used in the present invention contains 50% by mass or more of a semisolid oily base at room temperature.

  The oily base is not particularly limited as long as it is a semi-solid at room temperature that can be used as a base for cosmetics. Even if it is composed of one oily component, two or more It may be a blend of oil components. For example, one or more oily components as described below can be blended to prepare a semisolid oily base at room temperature.

  Examples of solid or semi-solid oils include petrolatum, solid paraffin, microcrystalline wax, ceresin, bees wax, barico wax, polyethylene wax, silicone wax, behenyl alcohol, stearyl alcohol, cetyl alcohol, batyl alcohol, carnauba wax, beeswax, candelilla wax, Jojoba wax, lanolin, shellac wax, whale wax, mole, myristic acid, palmitic acid, stearic acid, behenic acid, 12-hydroxystearic acid, cacao butter, hardened castor oil, hardened oil, hydrogenated palm oil, palm oil, hardened palm Examples thereof include oil, polyethylene powder, various water-added animal and vegetable fats and oils, fatty acid monocarboxylic acid lanolin alcohol ester, and the like. In the present invention, the oily base effectively prevents moisture transpiration from the skin and functions to retain water on the skin surface. Accordingly, the solid or semi-solid oil to be used preferably has a higher blocking property, and it is preferable to blend a solid or semi-solid nonpolar hydrocarbon oil such as petrolatum, microcrystalline wax, polyethylene wax or the like. Vaseline has particularly high occlusive properties, and it is most preferable to mix petrolatum in an oily base.

  The blending amount of the solid or semi-solid oil in the oil base is preferably 10 to 100% by weight, more preferably 20 to 100% by weight, and further preferably 30 to 100% by weight with respect to the total amount of the oil base. %. When the blending amount of the solid or semi-solid oil is less than 10%, high blockage may not be obtained. In particular, the solid or semi-solid non-polar hydrocarbon oil content is preferably 10% or more, more preferably 20% by mass or more, and still more preferably 30% by mass or more based on the total amount of the oily base. By blending a solid or semi-solid non-polar hydrocarbon oil with a high blending amount, higher blockage and high temperature stability can be provided.

  Furthermore, as long as the object of the present invention can be achieved, from the viewpoint of usability, a volatile oil component that is volatile at room temperature (25 ° C.) may be blended in the oil base. By blending a volatile oil, it is possible to further improve the spreading and stickiness after coating. The volatile oil that can be used in the present invention is not particularly limited as long as the object of the present invention can be achieved. For example, it has a low boiling point (boiling point of 260 ° C. or less at normal pressure) isoparaffinic hydrocarbon oil or low boiling point silicone oil. Etc. are preferably used. Specific examples of low-boiling isoparaffinic hydrocarbon oils include Isopar A, C, E, G, H, K, L, and M (all of which are manufactured by Exxon), Shellsol 71 (manufactured by Shell), Salt Roll 100, 130, 220 (all of which are manufactured by Philip), and the like, and are commercially available. Moreover, as low boiling point silicone oil, hexamethylcyclotrisiloxane, octamethyltetracyclosiloxane [for example, “Execol D-4” (manufactured by Shin-Etsu Silicone), “SH244”, “SH344” (all are Toray Dow Corning)・ Silicone Co.], decamethylcyclopentasiloxane [for example, “Execol D-5” (manufactured by Shin-Etsu Silicone Co., Ltd.), “SH245”, “DC345” (both made by Toray Dow Corning Silicone Co., Ltd.), dodecamethylcyclohexasiloxane Preferred examples include sasiloxane [for example, “DC246” (manufactured by Toray Dow Corning Silicone Co., Ltd.), tetradecamethylcycloheptasiloxane, etc. In particular, since it has excellent usability and high occlusion, it is volatilized. Decamethylcyclope as a natural oil It is preferable to mix tan siloxane, one volatile oil may be used alone, or two or more volatile oils may be used in combination. It is preferable that it is 50 mass%, More preferably, it is 10-40 mass%, More preferably, it is 15-30 mass%.

  Furthermore, as long as the object of the present invention can be achieved, a liquid oil component which is liquid at room temperature (25 ° C.) may be blended in the oil base. Specifically, non-polar hydrocarbon oils such as liquid paraffin and squalane, oils and fats such as olive oil, macadamia nut oil and jojoba oil, higher fatty acids such as oleic acid, tall oil fatty acid and isostearic acid, lauryl alcohol, oleyl alcohol and isostearyl Alcohol, higher alcohols such as octyldodecanol, esters such as isocetyl isostearate, myristyl myristate, isopropyl palmitate, chain polysiloxanes such as dimethylpolysiloxane, methylphenylpolysioxane, methylhydrogenpolysiloxane, benzophenone derivatives And UV absorbers such as fragrances, and the like. In particular, from the viewpoint of occlusive properties, it is preferable to blend non-polar hydrocarbon-based liquid oil such as liquid paraffin and squalane. You may mix | blend said liquid oil component individually by 1 type or in combination of 2 or more types. Further, the blending amount varies depending on the kind and combination of oils to be blended and is not particularly limited, but is preferably 10 to 90% by mass, more preferably 20 to 80% by mass, and still more preferably based on the total amount of the oily base. 30 to 70% by mass.

  The blending amount of the oily base is 50% or more with respect to the total amount of the external preparation, more preferably 60% or more, and further preferably 70% or more. A higher amount of the oily base can provide higher occlusion.

  Furthermore, from the viewpoint of usability, the oily skin external preparation used in the present invention preferably contains 5 to 50% by mass of powder. By blending such an amount of powder, it is possible to bring high occlusion to the skin without causing stickiness and shine when applied to the skin, and because it is very stretchable, a sufficient amount of occlusion can be achieved with a small amount. It is possible to bring

  The powder used in the present invention is not particularly limited as long as the object of the present invention can be achieved, but an extender is particularly preferable. For example, plate powder such as talc, kaolin, sericite, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, nylon powder, silica powder, silicone resin powder, silicone rubber powder, silicone resin-coated silicone rubber powder, polyurethane powder, etc. A spherical powder or the like can be preferably used in the present invention. Since spherical powder has a light diffusing effect, blending the spherical powder can blur the unevenness of the skin and make the wrinkles visually inconspicuous, and also like silicone rubber powder, silicone resin coated rubber, polyurethane powder When a powder having a high elasticity is blended, a touch without powderiness is obtained, which is more preferable. In particular, a spherical silicone rubber powder, a spherical silicone resin powder, a silicone resin-coated silicone rubber powder, an elastic silicone powder such as a zinc oxide-coated silicone resin-coated silicone rubber powder, or a spherical silicone powder, more preferably an average particle diameter of 1 to 50 μm. When an elastic or spherical silicone-based powder is blended, the spread is smooth and there is no powderiness, and a very excellent usability is obtained.

  Furthermore, various extender pigments with a powder having a refractive index of 1.6 or more, such as barium sulfate (refractive index 1.64), zinc oxide (refractive index 2.0), titanium oxide (rutile type) (refractive index 2.7). A high color unevenness hiding effect can be brought about by blending a powder coated or compounded or simply mixing a powder having a refractive index of 1.6 or more into a part of the powder. In the case of simple mixing, it is preferable to blend about 0.5 to 3% by mass of a powder having a refractive index of 1.6 or more in the oily skin external preparation of the present invention. When 3% or more is blended, the skin color becomes too white when it is applied to the skin, which is not preferable. On the other hand, when blending a powder coated or combined with a powder having a refractive index of 1.6 or more, it is high by blending about 5 to 30% by mass of such powder in the oily skin external preparation of the present invention. Color unevenness can be hidden. When a powder coated or combined with a powder having a refractive index of 1.6 or more is blended, a higher color unevenness hiding effect can be brought about than when a powder having a refractive index of 1.6 or more is simply mixed. It is more preferable because the skin looks beautiful when applied to the skin.

  You may mix | blend the above powders individually by 1 type or in combination of 2 or more types. Moreover, the compounding quantity becomes like this. Preferably it is 5-50 mass% with respect to external preparation whole quantity, More preferably, it is 10-40 mass%, More preferably, it is 15-30 mass%. When the blending amount of the powder is less than 5% by mass, there is a case where the oiliness and stickiness of the oil cannot be sufficiently improved, and when it exceeds 50% by mass, the blocking property is deteriorated.

In the present invention, the oily skin external preparation has an occlusive property of 50% or more, but preferably has a higher occlusive property, more preferably 60% or more, more preferably 70 in order to retain moisture on the skin more effectively. % Or more, more preferably 80% or more. For the occlusive property, a sample was applied to the internal region of the human forearm (2.5 mg / cm ² ), and the transdermal moisture transpiration (TEWL) after 1 hour was measured using, for example, Tewameter TM210 (Courage + Khazaka), MEECO (Meeco Measured using a moisture transpiration measuring device such as Warrington, PA, USA), Vapometer, or TEWA meter (Delfin Technologies Ltd, Kuopio, Finland), and can be obtained by the following formula:
Occlusion (%) = (1-TEWL (sample application) / TEWL (no sample)) × 100

  Oily skin external preparations include cosmetics, pharmaceuticals, quasi drugs and the like. In addition, examples of the dosage form include an ointment, a paste, or a cream.

  Furthermore, the oily skin external preparation used in the present invention includes, in addition to the above-described components, a moisturizer, a surfactant, an ultraviolet absorber, a fragrance, an antioxidant, an antiseptic / antifungal agent, an extender pigment, and a color pigment as necessary. Any component that is usually used in an external preparation for skin, such as a colorant, a pH adjuster, and the like, may be included as long as the effects of the present invention are not impaired. From the viewpoint of occlusive properties, those substantially free of water and water-soluble components are preferred, but they may be W / O type emulsions containing as little water as possible to achieve the object of the present invention. The amount of water and water-soluble components contained in the external preparation for skin is 10% by mass or less, more preferably 5% by mass or less, and further preferably 1% by mass or less.

  The wrinkle improving cosmetic method of the present invention may be performed alone or in combination with any other cosmetic method or skin care. Moreover, the frequency | count and the interval of the implementation are also arbitrary, for example, you may use every day or every other day for one week, two weeks or more.

  Further, the site of the skin to which the cosmetic method of the present invention is applied is not limited, and may be any site as long as the effects of the present invention are obtained, but fine wrinkles are usually easily formed on the face. The cosmetic method of the present invention is preferably applied to the skin such as the corners of the eyes, the lower eyelid, or the mouth.

  EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated concretely, this invention is not limited to the following Example.

1. Wrinkle improvement effect by applying weak current to skin As a weak current device, a patch sheet (hereinafter referred to as patch sheet (3V)) incorporating a 3 V battery, which is a general iontophoresis device, was used. A 3V battery was embedded in a patch sheet, and the positive electrode and the negative electrode were each coated with a hydrogel sheet containing 0.9% KCl. By attaching the positive electrode and the negative electrode to the skin through the hydrogel, a weak current can be applied to the skin.

  After washing 10 subjects, a patch sheet (3V) was affixed for 60 minutes so that the right eye area was a positive pole and the right cheek area was a negative pole. As a control, the same patch sheet (hereinafter referred to as patch sheet (0V)) in which no battery was embedded was pasted on the left eye corner for 60 minutes. While applying the patch sheet (3V), the current value was monitored with a digital multimeter. Further, photographs of the left and right eye corners were taken before sticking, 60 minutes after sticking (immediately after peeling), and 60 minutes after peeling.

FIG. 2 shows the outline of this experiment and the current density at the time of application. The current density was consistently about ² μA / cm ² .

In FIG. 3A, when the patch sheet (3V) (upper) or patch sheet (0V) (lower) is applied, the area of the corner of the eye corner before application, 60 minutes after application (immediately after release), and 60 minutes after release, respectively. Show photos. In addition, FIG. 3B shows a result (average value) obtained by allowing two judges to independently determine the wrinkle improvement effect based on the following criteria:
-1: Deterioration 0: No change 1: Slight improvement 2: Improvement

  The wrinkle was remarkably improved immediately after the patch sheet (3V) was applied for 60 minutes and a weak current was applied, but the effect almost disappeared after 60 minutes of peeling.

2. Change in water content of stratum corneum due to application of weak current to skin It was confirmed that the wrinkle-improving effect of applying weak current to the skin was due to the increase of stratum corneum water content by forced water retention in the positive side skin. Therefore, a patch sheet (3V) is applied to the inner part of the human forearm for 60 minutes to give a weak current to the skin. Before applying, 60 minutes after applying (immediately after peeling), and 60 minutes after peeling, the skicon (200) ) Was used to measure the stratum corneum moisture content of the positive electrode region, the negative electrode region, and the region where no electrode was attached (no electrode). The results are shown in FIG.

  Immediately after the weak current was applied for 60 minutes, the stratum corneum water content increased remarkably only in the positive pole side skin, suggesting that the increase in the water content contributes to wrinkle improvement. However, the stratum corneum moisture content decreased rapidly after peeling.

  Although the results are not shown, the moisture transpiration (TEWL) of the skin was not changed by the weak current. Therefore, it is considered that the weak current does not affect the barrier function of the skin.

3. Combined use of weak current and highly occlusive oily skin external preparation As described above, when a weak current is applied to the skin with a patch sheet (3V), the moisture content of the stratum corneum is transient due to forced water retention in the positive-side skin. However, it was thought that the wrinkle improvement effect disappeared in a short time because water was evaporated from the skin surface. Therefore, the application of a highly occlusive oily skin external preparation from the top of the skin whose water content was increased by a weak current was examined to maintain the moisture on the skin surface and enhance the persistence of the wrinkle improving effect.

  Similar to the above experiment, after washing the subject's face, a patch sheet (3V) was applied for 60 minutes so that the corner of the eyes became a positive pole, and a vaseline with high occlusive properties was applied immediately after the peeling. The wrinkle improvement effect when not doing was compared. FIG. 5 shows a photograph of the corner of the eye.

  By applying petrolatum immediately after peeling, the effect of improving wrinkles was maintained even after 60 minutes of peeling. On the other hand, when nothing was applied after peeling, the wrinkle improving effect almost disappeared 60 minutes after peeling.

Tables 1 and 2 show formulation examples of the oily skin external composition having a high occlusive property of 50% or more:

  After applying a weak electric current to the skin, an oily skin external composition having a high occlusive property of 50% or more was applied to the skin, and a high wrinkle improving effect could be brought about over a long period of time.

Schematic diagram showing the mechanism of forced water retention at the positive pole that occurs when a weak current is applied Schematic diagram of weak current experiment and graph showing change in current density A photograph of the corner of the eye that gave a weak current (FIG. 3A) and a graph showing the effect of improving wrinkles (FIG. 3B) Graph showing changes in stratum corneum moisture content due to weak current Photograph of the corner of the corner of the eye with and without applying petrolatum after applying a weak current

Claims (5)

After applying a weak direct current for 0.5 to 120 minutes with the skin as a positive electrode , the skin contains 50% by mass or more of a semi-solid oily base at room temperature and has an occlusion of 50% or more. A wrinkle-improving beauty method (excluding medical practice), characterized in that an oily skin external preparation is applied to the skin. The wrinkle-improving cosmetic method according to claim 1, wherein the oily base contains petrolatum. The wrinkle improving cosmetic method according to claim 1 or 2, wherein the oily skin external preparation further contains 5 to 50% by mass of a powder. The wrinkle improving cosmetic method according to any one of claims 1 to 3, wherein the skin is a skin of an eye corner, a lower eyelid, or a mouth. The method for improving wrinkles according to any one of claims 1 to 4, wherein the amount of water and water-soluble components in the oily skin external preparation is 1% by mass or less, respectively.