JP4659837B2 - Device for administering a dosage of a fluid formulation comprising a torsion spring drive - Google Patents

Description

  The present invention relates to a device for dispensing a fluid formulation in dosages, comprising a torsion spring drive. The device can in particular be an injection device which is preferably in the form of an injection pen. Injection devices are known, for example, for the treatment of diabetes, the administration of growth hormone or osteoporosis prescription drugs. Such a device on the one hand ensures that the correct dosage is administered, and on the other hand, the device must be simple and convenient to operate. These requirements are particularly important when the user administers the appropriate formulation himself.

  For example, an injection device, such as that known from WO 01/10484, comprises a transfer means, a dose setting means and a drive means. The user applies the driving force required to administer the formulation himself by loading the driving means with the driving force. The drive means is connected to the transfer means so that the introduced driving force is converted into the transfer movement of the transfer means.

  An injection device uses a drive spring to generate a drive force, which is tensioned to set a dosage and releases stored energy during dispensing, which is a It is known from 053214. A spring wound in a spiral around an axis acts as a drive spring with its windings located adjacent to each other along the axis. Because of the drive spring, the user no longer needs to apply a drive force, so that he can concentrate more on the other manual operations required for administration, while the injection device is a constant predetermined Only dosages can be administered.

  One object of the present invention is to provide a device for administering a fluid formulation which can be easily and reliably operated and which allows the dosage to be administered to be set freely.

  The present invention relates to a device for dispensing a fluid formulation comprising a casing having a reservoir. The reservoir itself should form a container for the formulation or preferably be capable of receiving a container for the formulation, such as an ampoule. The device also has transport means for transporting the formulation from the reservoir or from a container that is preferably received in the reservoir. The apparatus includes: a coupler member capable of rotating around a rotation axis to drive the transfer means; a first block member connected to the coupler member to be fixed so as not to rotate; and a second block Member. When the second block member is releasably block-engaged with the first block member, the first block member, and thus the coupler member, prevents rotational movement in the driving direction and the first block member The member, and thus the coupler member, allows rotational movement in the opposite dosing direction. Finally, the apparatus has a torsion spring and a trigger element coupled to the at least one block member, such that the trigger movement of the trigger element moves the at least one block member out of block engagement. To do. The torsion spring is connected to the coupler member, and when the block member is in block engagement, the torsion spring is tensioned by the rotational movement of the coupler member in the dosing direction and the spring energy thus stored is After the block engagement state is released, the coupler member is released, and the coupler member is driven to rotate in the driving direction.

  In accordance with the present invention, the trigger element serves the dual function of releasing the block engagement and consequently forming a dosage setting member for setting the dosage as well as the action of triggering the torsion spring. The trigger element is correspondingly connected to the torsion spring, and when the block member is in block engagement, the torsion spring is tensioned by the dose setting movement of the trigger element. For trigger movement, the trigger element is preferably capable of translational movement along the axis of rotation. Due to the dosage setting movement, the trigger element is preferably able to move in a rotational manner around the axis of rotation. Advantageously, the trigger element is placed in the proximal region of the injection device so that it can be handled more easily when administering the formulation. Due to the triggering function, the triggering element preferably forms a push button that, when administered, is operated towards the direction of the administration position.

  In preferred embodiments, the dosage can also be modified by a trigger element. Due to the correction function, the trigger element is connected to at least one block member, so that the backward movement of the trigger element moves the corresponding block member to release the block engagement state. In order to modify the dosage, the torsion spring is decoupled from the transfer means so that the formulation is not accidentally discharged. The torsion spring can be disconnected by a backward movement. Preferably, however, the coupler driving the transfer means connects the torsion spring to the coupler. In the rest state, where the trigger element is unstressed, the device is always in position, the coupler is released, while the trigger element is still coupled to the coupler member, even during the retracting movement. In its fully retracted state, it is desirable for the user to be able to prevent the coupler member from rotating in the drive direction by holding the trigger element. Even if there is an operational error while modifying the dosage, at best, the set dosage will be reduced below the desired level, but this dosage will free the trigger element and reduce the dosage. By resetting, it can be corrected again without producing any further results. The backward movement is preferably directed in the opposite direction to the direction of the trigger movement.

  In an embodiment in which the holding means holds the coupler in the released state, i.e., the retracted state when the block member is in the block engaged state, and the transfer means and the coupler member are decoupled from each other, the coupler member and the transfer means are triggered It is desirable to be connected to each other by the trigger movement of the elements. During the trigger movement, the trigger element not only releases the block engagement state of the block member, but also establishes the coupler engagement state in the same movement process, and the block engagement state of the block member is released. Then, through this movement, the torsion spring drives the transfer means. For this purpose, the trigger movement is preferably divided into functional stages that proceed in sequence, but preferably it is carried out continuously. Preferably, the coupler member is connected to the transfer means so that the block engagement state is released at a subsequent stage if the connection state already exists. The engagement state of the coupler is embodied to last long enough to overlap in the direction of movement of the coupler.

  In one development, the trigger element not only serves a dual function according to the present invention, but preferably, if the device is provided with an injection needle and the device is not formed as a pressure injection device, the third As a function of, trigger the injection by the needle. The needle protector is connected to the casing and the elasticity is connected to the trigger element by a resistance element through the casing, and the needle protector moves upward and against the resistance element in the first stage of the injection process In addition, the trigger element acts on at least one of the needle protection part and the resistance element via the coupling mechanism at a position taken by the needle protection part after that, and a positive locking or frictional locking state between them ( The state in which the needle protector is prevented from moving further in the proximal direction is released. The connection mechanism for the injection process is controlled in this manner, and the connection between the trigger element and the at least one block member is configured to release the block engagement state as follows: That is, during the trigger movement, the trigger element is first configured to release the needle protector so that the injection needle penetrates, and the block engagement state of the block member is released only during the subsequent trigger movement. It is said.

  In a preferred embodiment in which the device has a coupler that can be extended and retracted, the coupler connects the coupler member to the transport means in the coupler engaged state, i.e., the extended state of the coupler, and to a torsion spring that discharges the formulation The driving force is transmitted to the transfer means. In the retracted state, the device uncouples the transfer means from the coupler member, for example, sets the dosage, and in particular the operations performed on the coupler member to modify the dosage do not affect the transfer means. Like that. In such an embodiment, the trigger movement of the trigger element is such that the coupler engagement is established by the coupler movement of a coupler member, preferably a coupler member as described above or a number of coupler members, preferably including a coupler member as described above. To do. In such an embodiment, the coupler member is a coupler member in the narrow sense, whereas in a simple embodiment, the coupler member may always be connected to the transfer means, but will discharge. For that purpose, of course, it must first be released by performing a trigger movement.

  The coupler is composed of at least two coupler members, the above-described coupler member forming the coupler input member, and the other coupler member connected to the transfer means as a coupler output member. At least one coupler member, preferably the coupler input member, can be moved into coupler engagement, and at least one coupler member (preferably, but not necessarily, the same coupler member) (Not necessary) may be moved out of the coupler engagement state.

  According to the invention, the device also has holding means for holding the coupler members in a holding position which is released from each other. Correspondingly, at least one coupler member can be moved from the holding position to the coupler engaged state by movement of the coupler. When in the holding position, the force flow between the coupler members is interrupted. On the other hand, when the coupler is engaged, the driving force of the driving member can be transmitted to the transfer means via the coupler member and cause the movement of the transfer means to be discharged.

  When in the coupler engaged state, the engagement elements of the corresponding coupler members that are simply pressed against each other in a frictional locked state, as if they were securely locked together or applicable, are Retreating. The coupler members themselves can actually contact each other even in the holding position, but their engaging elements are not in contact when in the holding position. However, preferably, the coupler members (coupled in their connected state) are fully retracted from each other in their disconnected state.

  In a preferred embodiment, the holding means is or has a return member that reacts with a resilient return force against the movement of the coupler. Instead of holding the coupler in the disconnected state by elastic force at the holding position as preferred, the holding means can also act in a positively locked state by fixing at least one coupler member. The at least one coupler member performs the coupler movement in a casing or structure that is fixedly connected in a positive locked state that is releasable at least against the coupler movement. The torsion spring itself forms the return member or the return member may be provided specifically for the holding function.

  In the coupled state of the coupler, the coupler input member and the coupler output member can be directly in coupler engagement with each other. However, in one development, the coupler has a coupler intermediate member through which the coupler input member is coupled to the coupler output member in a coupler engaged state. In a particularly preferred embodiment, a coupler engagement is established between the coupler input member and the coupler intermediate member. It is preferable that the coupler intermediate member is engaged with the coupler output member even when the coupler intermediate member is in the holding position of the coupler member, that is, in the disconnected state (the driving force can be transmitted in this state). Desirably, the coupler member can be moved relative to the coupler output member in the engaged state, preferably in the direction of movement of the coupler and vice versa.

  In a further development, the coupler output member is fixed to the casing in the holding position of the coupler member, and the coupler output member cannot perform any movement that would cause the movement of the transfer means to discharge. The coupler output member is preferably allowed to slowly release in direct association with the dispensing of the formulation. Advantageously, the fixed state of the casing is released by moving the coupler. Preferably, the coupling state of the coupler is established in the first stage between the path portions that have moved during the movement of the coupler, and the fixed state in the casing is preferably the holding means in the subsequent second stage. To be released against the elastic return force described above. Preferably, the coupler output member is fixed to the casing through the coupler intermediate member at the holding position of the coupler member. For this purpose, it is desirable that the block engagement existing between the coupler intermediate member and the casing or the structure connected to the casing is released by performing the coupler movement. It is desirable that the coupler intermediate member is moved in the direction of movement of the coupler so that it is in a block disengaged state, which is that this is movable because the coupler intermediate member is simply driven while the coupler is moving. For example, it is allowed to be released from the block engagement state by being pushed. The block engagement state may be a positive engagement lock state and / or a friction lock engagement state.

  In the first modification, the return member acts on the coupler member via the coupler intermediate member and holds the coupler member in the holding position. In a second variant, the return member acts directly on the coupler member and, for example, for loading, in a structure connected to the casing or fixedly to the casing with respect to the movement of the coupler or the coupler output member Supported by

  The coupler output member is preferably engaged with the transfer means in a threaded engagement, but in an alternative embodiment, in principle, in order to discharge the formulation, You may make it connect indirectly. When in the threaded engagement state, which is a preferred state, the rotational movement of the drive member is preferably converted into a parallel movement movement of the transfer member of the transfer means. Preferably, the threaded engagement state is not self-locking, but allows the transfer member to move axially in the direction of the threaded axis by a force applied to the transfer member. Can be moved in a parallel movement state in a threaded engagement state.

  The device preferably has a dosage display for displaying the set dosage of the formulation. The display may be an audible display and / or a tactile display and / or in particular an optical display. The dosage display is coupled to the dosing member such that when the dosage of the formulation is set, the movement of the dosing member changes the displayed dosage of the formulation. In the holding position of the coupler member, the dosing member and / or the dosing display is left disconnected from the transport means. This uncoupled state allows the dosage to be set and corrected, if necessary, in the uncoupled state without giving a feedback effect to the transfer means.

  In one preferred embodiment, the connection between the dosage display and the torsion spring is also present in the engaged state of the coupler, with respect to the direction of movement that sets the dosage as dispensing progresses. The driving movement of the torsion spring in the opposite direction is reset progressively in the same way. Thus, if dosing is intentionally or accidentally or unintentionally stopped prematurely, the dosage display will show the remaining dose that has been set but not yet dispensed. This may be beneficial, for example, when the set dose is greater than can still be delivered.

  In the coupler engaged state, the trigger element is uncoupled from the torsion spring so that any operation that would give a feedback effect to the torsion spring cannot be performed while the torsion spring is driven by the trigger element. It is desirable that

  The torsion spring can in particular be a spiral spring. The spiral spring is preferably wound around the axis of rotation of the rotational movement and at least one outer spring winding surrounds the inner spring winding. The spring preferably exhibits a zero pitch with respect to the entire rotational axis. Using spiral springs can save axial length, especially when compared to prior art springs, where the windings are positioned adjacent to each other. One end of the spiral spring, preferably the radially inner end thereof, is connected to the coupler input member so that the radially inner end is fixed so as not to rotate. The other end, preferably the radially outer end, is connected to the casing so as not to rotate. The coupler input member preferably forms a reel on which a spiral spring is wound. When setting the dosage, the coupler member is rotated about the axis of rotation, which tensions the spiral spring.

  The movement of the coupler is preferably a stroke movement in the axial direction. If the piston and piston rod form the transfer means, the movement of the coupler is preferably carried out in the advance direction of the piston and piston rod. The coupler member between which the coupler engagement state is formed can be provided with an engagement element that cooperates as a groove and a spring, particularly when in the coupler engagement state. The grooves and springs can be displaced axially with respect to one another, or should be formed as teeth or more preferably as conical teeth facing axially with respect to one another. For example, a single tooth and a single tooth gap are in principle sufficient for coupler engagement, but at least one coupler member forming the coupler engagement state has a tooth portion surrounding the rotational axis. It is preferable to be provided. More preferably, for coupler engagement, each of the two coupler members is provided with a tooth portion in the circumferential direction. The same applies to engaging elements formed as grooves and springs or otherwise. Regardless of the shape of the coupler region, the coupler engagement state is formed such that no slip occurs in the coupler engagement state.

  The casing has at least two casing parts that can be removed from one another, one of which forms a reservoir and the other to which a torsion spring, coupler member and block member are attached. A release mechanism is provided. The decoupling mechanism is connected to at least one block member, and for this purpose, when the casing part is removed by a relative movement performed between the casing parts, the block member is released and the torsion spring is already If not in the zero dosage position, move the coupler member to the zero dosage position. The connection release mechanism has a connection release member that is moved to the connection release position by a relative movement performed when the casing portion is removed. The movement of the connection release member causes the connection release member to be connected to at least one block member so that the corresponding block member moves and is released from the block engagement state. The decoupling member acts on the coupler member and moves the coupler member to the decoupled position, the coupler member preferably moving the corresponding block member out of the block engagement state via a driven engagement. It is preferable. When in the decoupled position, the decouple member desirably decouples the coupler member from the transport means.

  In another development, the first block member connected to the coupler member to be fixed so as not to rotate is in addition to the block function, another function, that is, the function that the coupler member limits the rotational movement in the driving direction. Fulfill. In this other function, the block member determines the zero dose position of the coupler member. For this purpose, the first block member is provided with a threaded portion around the rotational axis, and at least one rotation stopper that engages with the stop member is formed at one end of the threaded portion. The casing or the structure connected to the casing so as not to move guides the stop member parallel to the axis of rotation so that it is fixed against rotation. The stop member moves axially in the front-rear direction during setting and dispensing of the dosage, and stops the rotational movement of the coupler member when contacting the rotation stopper.

  The first block member can be connected to the coupler member such that the block member cannot move axially. Preferably, however, the coupler member and the first block member can move axially relative to each other, and the first block member is elastic until the first block member abuts against the coupler member as much as possible. The block is engaged by being pushed in the axial direction by the return member. It is also desirable that the return member is a return member of the holding means.

Preferred features are also set forth in the dependent claims and combinations thereof.
The features described in the above-described embodiments and dependent claims develop the subject matter of claim 1 in a particularly desirable manner, which is also desirable for an injection device comprising a torsion spring which does not exhibit feature h) It is. These are more desirable when the trigger element itself of such an injection device that releases the block engagement forms the block member. However, the latter also applies in principle to the present invention, i.e. when, for example, the dose setting movement of the trigger element is not released due to the movement of the dose setting of the trigger element because the movement of the dose setting is an axial movement. Is also true.

  An embodiment according to an example of the present invention will be described below based on features. Features disclosed by way of example embodiments, each individually or in any combination of features, are intended to develop the subject matter of the claims as well as the embodiments described above as desired.

  FIG. 1 shows an injection device according to an embodiment of the first example. The injection device comprises a first casing part 1 and a second casing part 4 detachably connected to each other. In an exemplary embodiment, the casing parts 1, 4 are screwed together. The injection device is formed as an elongated injection pen. The casing part 1 serves to receive a container 2 filled with a fluid formulation, at which point it forms a reservoir, the casing part 4 being able to see the dosage member 18 at a dosage setting and drive. Acts as a support for the means. The casing part 4 is torn within the area of the dosage setting member 18 so that the user can access the dosage setting member 18 directly. The dosage setting member 18 is attached so that the dosage setting member can rotate around the central axis in the longitudinal direction of the apparatus, and a rib is provided on the outer peripheral surface thereof so that the user can easily use it. Formed as a sleeve. It is also possible to see the dosage display 20 arranged laterally through the crevice of the shell of the casing part 4.

FIG. 2 is a longitudinal sectional view of the injection device according to the first embodiment. The container 2 is received in the casing part 1. A piston 3 is received which can move in the container 2 in the forward direction V. The piston 3 seals the container 2 at its proximal end in a fluid impermeable manner. As the piston 3 advances in the forward direction V, the formulation is preferably discharged from the outlet of the container 2 through an injection needle that projects into the outlet and is fastened to the end of the casing part 1 by a needle holder. The container 2 is formed in the form of a conventional ampoule. The casing 1 directly forms the container holder and the ampoule holder in the embodiment according to the example. The proximal end of the casing part 1 protrudes into the casing part 4 and is screwed to the casing part 4.

  The casing part 4 receives the piston rod 15 and the dosage setting and driving means formed as a dosage setting and driving mechanism. In the dosage setting and driving line, the dosage setting and driving means includes a driving member 5 and couplers 6 to 11 for connecting the driving member 5 to the piston rod 15 in a connected state, that is, in a coupler engaged state. The piston rod 15 forms a transfer means together with the piston 3. When in the coupled state, the coupler members 6 to 10 transmit the driving force applied to the driving member 5 to the piston rod 15. In FIG. 2, the coupler engagement state does not exist, and for this reason, the piston rod 15 is disconnected from the drive member 5. When in this disengaged state, the user can set the dosage setting movement of the dosage setting member 18, i.e., the dosage of the formulation to be administered by a rotational motion in one embodiment.

The drive member 5 has a sleeve shape. In the outer region of the shell, the drive member is provided with a thread around a threaded axis R oriented in the forward direction V. The drive member 5 is in a threaded engagement with the coupler input member 6 via this threaded portion. The coupler input member 6 also has a sleeve shape and is provided with a corresponding internal thread portion for screwing engagement. The screw pitch in the screwed engagement state is sufficiently large so that the self-locking state cannot be generated. The dosage setting member 18 surrounds the coupler input member 6 and is connected to the coupler input member 6, the dosage setting member is fixed so as not to rotate and cannot move axially. The piston rod 15 protrudes into the drive member 5 and the coupler input member 6.

  The piston rod 15 is provided with an external thread portion over its axial length. The piston rod is in threaded engagement with the coupler output member 9 provided with a corresponding internal thread through the external thread. These two threaded parts also show a thread pitch that prevents self-locking in the threaded engagement state. The screw pitch is preferably equal to or less than the screw pitch when the driving member 5 and the coupler input member 6 are in the threaded engagement state. The coupler sleeve 8 is connected to a coupler output member 9, which is fixed so as not to rotate and cannot move axially. The coupler sleeve 8 and the coupler output member 9 can be regarded as an integral component with respect to the movement between the drive member 5 and the piston rod 15. However, in order to receive the balance spring 17, they are embodied as two parts and are fixedly connected to each other. The coupler output member 9 and the coupler sleeve 8 are mounted in the casing part 4 so that they can rotate around the threaded axis R of the coupler output member 9 but cannot move axially. When in the threaded engagement state, the piston rod 15 projects through the coupler output member 9 and projects into the coupler sleeve 8. A balance spring 17 is fastened between the proximal end of the coupler sleeve 8 and the proximal end of the piston rod 15 and acts on the piston rod 15 in the forward direction V as a pressure spring. The balance spring 17 is pressed against the piston rod 15 via a disk 15a, so that the disk can be rotated by the piston rod 15 and forms a flange of a sleeve disposed on the piston rod 15. It is supported.

  The piston rod 15 is guided linearly in the linear guide portion 4a in the forward direction V and in the direction opposite to the forward direction V so that the piston rod cannot rotate with respect to the casing portion 1. The The drive member 5 is guided linearly relative to the casing part 4 so that the drive member can move in the forward direction V and in the opposite direction of the forward direction V, and for this purpose the casing part 4 is The linear guide 4b is directly formed.

  The threaded axis of the piston rod 15 forms the main movement axis of the device. The threaded axis forms a rotational axis R for movement that drives the coupler input member 6 and the coupler output member 9 via the coupler intermediate member 7 in a rotational manner. This rotational axis forms both threaded axes. This rotational axis also forms a translational movement axis with respect to the piston rod 15 and the drive member 5.

  The couplers 6 to 11 also have a coupler intermediate member 7 and a return member 10. The return member is formed as a pressure spring and loads the coupler intermediate member 7 with an elastic force acting in the direction opposite to the forward direction V. The return member 10 is fastened between the coupler output member 9 and the coupler intermediate member 7.

  If a force acting in the forward direction V is not applied to the drive member 5, the return member 10 ensures that the coupler engagement state is released via the coupler intermediate member 7. This state is shown in FIG. The coupler input member 6 is pushed in the forward direction V until the input member abuts against the coupler intermediate member 7, and is pushed to the proximal end position by the return member 10 via the coupler intermediate member 7. Due to the coupler intermediate member, the return member 10 holds the coupler input member 6 in a position to hold the coupler output member 9 and the coupler sleeve 8 fastened to the coupler output member. In this way, the return member 10 and the coupler intermediate member 7 form a holding means that acts on the coupler input member 6 in an uncertain locking state.

  FIG. 3 shows the injection device in a connected state. A coupler engagement state exists between the coupler input member 6 and the coupler sleeve 8. For the coupler engaged state, the coupler input member 6 and the coupler sleeve 8 form an engaging element, which is in the coupler engaged state about the threaded axis R facing the forward direction V. A connection is established between the two members 6 and 8 that is rotatably fixed. The engaging elements cooperate as grooves and springs or teeth that are formed parallel to the advancing direction V and are evenly distributed around the threaded axis R.

  4 and 5 show the coupler engagement area in detail. FIG. 4 shows the device in a disconnected state, and FIG. 5 shows the device in a connected state. 4 corresponds to FIG. 2 and FIG. 5 corresponds to FIG.

  When in the disconnected state, the coupler input member 6 is retracted from the coupler sleeve 8 in a direction opposite to the forward direction V, and the coupler input member 6 is fixed to the coupler sleeve 8 and thus to the coupler sleeve. The coupler output member 9 connected to can be freely rotated. The coupler output member 9 is connected simultaneously with the casing portion 4 via the coupler sleeve 8, the coupler intermediate member 7, and the connection release member 11 so as not to rotate. For this rotationally fixed connection, the coupler intermediate member 7 is provided with an engagement element 7b in the inner region facing the coupler sleeve 8 in the radial direction, the coupler sleeve 8 having a corresponding engagement element 8b. Is provided. The coupler intermediate member 7 is provided with an engagement element 7a in the outer peripheral region for engaging with the connection release member 11 in a rotatable manner, and the connection release member 11 is provided in the inner region of the shell. A radially facing engagement element 11a is provided, which, in the disengaged state, is similar to the engagement elements 7b, 8b in the form of grooves and springs or teeth parallel to the advance direction V. Are locked together. The coupler intermediate member 7 is directed in the forward direction V and in the forward direction V in its rotatable fixed engagement state with the coupler sleeve 8 and in its rotatable fixed engagement state with the disconnection member 11. It can be moved axially in the opposite direction, in which case the engagement with the disengagement member 11 is released when the member moves in the advance direction V.

  When the drive member 5 is operated by applying pressure to the trigger element 16 in the forward direction V, both the drive member 5 and the coupler input member 6 complete the coupler stroke in the axial direction of length X. . Due to the movement of the driving stroke or the movement of the coupler, the coupler input member 6 pushes the coupler intermediate member 7 in the forward direction V against the elastic force that the return member 10 returns. In the stroke movement process, the coupler intermediate member 7 moves relative to the release member 11 until the intermediate member is released from the fixed engagement state in which the intermediate member is rotatable with the release member 11, and at the same time, the engaging element 6a, 8a advances to the state which mutually engages. The coupler intermediate member 7 maintains a fixed engagement with the coupler sleeve 8 that can rotate. Coupler movement is limited by the stop of the trigger element 16 in the region facing the proximal end (FIG. 3) in the embodiment of the coupler sleeve 8, an example.

  FIG. 5 shows the injection device in a connected state. The engagement elements 6 a and 8 a are overlapped in the axial direction, and the coupler engagement state is established between the coupler input member 6 and the coupler sleeve 8 as an engagement state in which the coupler engagement state is rotatably fixed. The engagement between the coupler intermediate member 7 and the decoupling member 11 is not released until the coupler engagement state is reliably established.

  To set the dosage, the user turns the dosage setting member 18. The dosage setting member is locked in an easily releasable locking position. The dosage setting member 18 is fixed so that the dosage setting member does not rotate and cannot be moved axially, so that the coupler input member 6 and the coupler input member 6 are rotated so that the coupler input member rotates together with the dosage setting member. It is connected. At reference numeral 4b, the drive member 5 guided linearly in the forward direction V and in the opposite direction of the forward direction V is moved toward the proximal direction by the dosage setting movement of the coupler input member 6, Next, it protrudes from the casing part 4. The axial dosage setting path of the drive member 5 follows the rotation angle at which the dosage setting member 18 rotates and the thread pitch of the threaded engagement state between the drive member 5 and the coupler input member 6. The coupler input member contacts the coupler intermediate member 7 in the forward direction V and contacts the casing portion 4 in the opposite direction to the forward direction V.

FIG. 6 shows an injection device having a container 2 that is still completely filled after the first dose has been set. When in this state, the user penetrates the needle into the skin for subcutaneous injection. When the injection needle is arranged, the user operates the drive member by pushing the drive member 5 into the casing portion 4 in the forward direction V. In the first part of the driving movement, the coupler movement or the coupler stroke X, the driving member 5 is established in the coupler engagement state with the coupler sleeve 8 and between the coupler intermediate member 7 and the disconnection member 11. The coupler input member 6 is driven against the elastic return force of the return member 10 until the rotationally fixed engagement state is released. As soon as the coupler sleeve 8 and the coupler output member 9 together with the coupler sleeve are free to rotate about a common threaded axis R, the coupler stroke X is completed and the discharge stroke is driven as a second part of the movement. continue. During the discharge stroke, the drive member 5 is further pushed in the forward direction V. When the coupler input member abuts against the coupler intermediate member 7 in the axial direction, the coupler input member 6 cannot perform any further movement in the forward direction V, so the coupler input member does not rotate. Rotate around a common threaded axis R in a threaded engagement with the drive member 5 guided to be fixed. When rotated in the coupler engagement state, the coupler input member 6 drives the coupler sleeve 8, and the coupler sleeve 8 drives the coupler output member 9. The coupler sleeve 8 is held in the casing part 4 together with the coupler output member 9, and the coupler sleeve cannot be moved axially. The rotational movement of the coupler output member 9 advances the piston rod 15 through the threaded engagement state with the piston rod 15 and the linear guide 4a fixed to the piston rod 15 so that the piston rod 15 can move forward. The movement which the piston 3 discharges is produced. The discharge process is completed as soon as the injection button 16 proceeds to a contact relationship in contact with the coupler sleeve 8 in the process of driving and discharging (FIG. 3).

  When the user removes pressure from the trigger element 16, the return element 10 returns the coupler input member 6 to the holding position retracted from the coupler engaged state via the coupler intermediate member 7, as shown in FIGS. The coupler input member 6 and together with the coupler input member, the drive member 5, the dosing member 18 and the dosing display 20 are disconnected from the coupler output member 9 and thus from the piston rod 15 by the reversing movement of the coupler input member 6. . On the other hand, the piston rod 15 is again connected to the casing part 4, and the piston rod is fixed so as not to rotate via the returning coupler intermediate member 7 and the coupling release member 11.

FIG. 7 shows the injection device when the last discharge after emptying the container 2 is completed.
In order to replace the empty container 2, the casing part 1 is removed from the casing part 4 by a screwing movement in an exemplary embodiment. When the casing parts 1, 4 are removed, the decoupling member 11 is directed in the opposite direction to the direction in which the coupler of the coupler input member 6 moves, ie in the embodiment according to the example, in the opposite direction of the advance direction V. It is automatically moved relative to the casing part 4. Accordingly, the casing part 4 is attached with the connection release member 11. Thus, the axial path along which the decoupling member 11 moves relative to the casing part 4 is as long as the coupler stroke X, so that when the casing parts 1, 4 are removed, they face the coupler input member 6. The axially disengagement member 11 blocks its path and the coupler input member 6 can no longer move in the forward direction V, i.e. at least in coupler engagement with the coupler sleeve 8. I can't. Blocking the coupler input member 6 in the disengaged position prevents the coupler output member 9 from proceeding to a rotationally fixed connection with the casing part 4, and therefore the piston rod 15 is retracted. Will be blocked. In other words, this ensures that the piston rod 15 can be retracted into the casing part 4 without being blocked.

  FIG. 8 is a perspective view of the connection release member 11 and the first casing portion 1. The decoupling member 11 is a sleeve portion, and includes a distal portion, three engaging elements 12 protruding radially inward, and a fixing element 13 protruding radially outward at a proximal portion. Yes.

  In FIG. 9, the casing part 1 and the connection part of the casing part 4 are shown, and the hidden connection release member 11 is shown by a broken line. Due to its decoupling function, the decoupling member 11 is received in the connecting part of the casing part 4 so that the decoupling member can rotate and move axially. The relative mobility is determined by the axial guide 4e and the peripheral guide 4c. When the casing part 1 is removed from the casing part 4, the fixing element 13 moves continuously along the peripheral guide. The peripheral guide 4c extends perpendicularly to the circumferential direction around the screw axis with respect to the axial guide 4e. The peripheral guide is formed as a crevice or cavity in the casing part 4.

  The connection release member 11 is in a guide engagement state with the casing portion 1. Due to the guide engagement state, one guide curve 1a per engagement element 12 is formed in the outer region of the shell of the casing part 1 and when the casing parts 1, 4 are removed, the engagement part 12 Therefore, the connection release member 11 is guided. Therefore, when the casing portions 1 and 4 are connected (FIG. 10), another guide curve portion 1a separated in parallel guides the connection release member 11. In the end part, the guide curve part 1a forms an angle with respect to the screw axis of the screw connection part between the casing parts 1 and 4, i.e. extends at a certain pitch, in order to remove the casing parts 1 and 4 During the required relative rotation between these casing parts, the engagement element 12 moves the decoupling member 11 axially relative to the casing part 4 in the direction opposite to the advance direction V and is fixed. The element 13 slides along the guide curve portion 1a until it reaches the axial height of the peripheral guide portion 4c. The pitch is about 45 ° and is constant. In principle, the pitch can be chosen in the whole range from 0 ° to 180 ° and, if appropriate, the relative movement required to remove the casing parts 1, 4 (as an example) In the embodiment, the change can be made as long as the movement of the coupling member causes the coupler input member to move in the direction opposite to the X direction of the coupler to be performed for the coupling. The end portion of the guide curve part 1a extends in the axial direction, so that the fixing element 13 is moved along the peripheral guide part 4c when the casing parts 1, 4 are further screwed and separated. In the process of moving in the relatively peripheral direction between the disconnecting member 11 and the casing part 4, the fixing element 13 slides on the fixing element 4d in the region of the peripheral guide 4c. The fixing element 4 d is formed as a cam in the strip part of the casing part 4. The strip portion is fastened and elastically applied on both sides when the fixing element 13 moves over the fixing element 4d and then rebounds back to its original position and against the decoupling member 11 Acts as a spiral spring that forms a releasable locking engagement. When in the locked position, the fixing element 13 abuts against the fixing element 4d in the circumferential direction, and abuts against the collar formed on the peripheral edge guide portion 4c in the other circumferential direction, thereby causing both circumferential directions. Fixed.

  FIG. 10 shows the two casing parts 1, 4 and the connection release member 11 after the fixing element 13 has moved behind the fixing element 4 d of the casing part 4. The connection release member 11 is in a releasable engagement state with the casing part 4 via the fixing elements 4d, 13 and is thus fixed in the axial direction by the casing part 4, and the connection release member rotates. It is fixed not to. In the locking position shown in FIG. 10, the connection release member 11 blocks the coupler input member 6 and thereby ensures that the drive member 5 and the piston rod 15 are in the connection release state. The engagement element 12 moves so as to be released from the guide engagement state with the guide curve portion 1a as soon as the connection release member 11 reaches the locked position and the casing portions 1 and 4 are screwed and further separated. The guide curve portion 1a has a shape corresponding to this.

  When the casing parts 1, 4 are screwed together again, these casing parts are centered with respect to the circumferential direction by cooperating centering elements, and the engaging element 12 of the decoupling member 11 is guided by a guide curve. Re-engage with the part 1a. As soon as the guide engagement is established and further screwed together, the connection release member 11 again assumes the same position relative to the casing part 4 as shown in FIGS. 9 and 2-7. Until it automatically moves out of the locked engagement with the fixing elements 4d and 13. This position corresponds to an operable position of the connection release member 11.

  While being screwed together or before being screwed, the piston rod 15 simply retracts into the casing part 4 so that, due to the released coupler engagement, the coupler output member 9 has a rotational movement. .

The dosage display 20 of the embodiment according to the first example is connected to the drive member 5 via the display connecting member 21 and the coupler input member 6. The display connecting member 21 is fixed against rotation by being able to move on the coupler member 6 and relative to the coupler member and in the opposite direction to the direction X of movement of the coupler. Connected to the puller input member 6 to form a ring in an exemplary embodiment. On the contrary, the display connecting member 21 can be rotated with respect to the casing part 4 around the rotation axis R, but is held so as not to move in the axial direction with respect to the casing part 4. The display connecting member 21 includes a tooth portion formed as a conical tooth portion in the embodiment according to the example, and the connecting member allows the movement of the dose setting and the driving motion to be within the gear via the tooth portion. In a toothed engagement with the gear of the dosage display 20 for introduction into
11 to 18 show an injection device according to an embodiment of the second example. The injection device of the embodiment according to the second example has several changes compared to the device of the embodiment according to the first example with respect to the connection and disconnection of the drive member 5 and the piston rod 15. . The drive member 5 and the piston rod 15 itself, and the manner in which they cooperate when they connect and disconnect, remain in principle the same. Functionally identical components are indicated with the same reference numbers as in the first embodiment. In order to display differences, related components are displayed with the same reference number with an apostrophe.

  FIG. 11 shows the injection device in its resting state. In this case, the drive member 5 is disconnected from the piston rod 15. The first casing part 1 is covered with a protective cap 37 that is connected to the casing part 4 and is removed for dispensing the formulation. Unlike the embodiment according to the first example, a coupler engagement state is established and released between the modified coupler input member 6 'and the modified coupler intermediate member 7'.

  FIG. 12 shows a second example embodiment of the injection device in its connected state, which is connected to the trigger element 16 and thus the drive member 5 and the coupler input member 6 ′ in the forward direction. It is established by loading with a driving force acting toward V. However, in FIG. 3 corresponding to the embodiment according to the first example above, no dose has yet been selected or only a few very few doses are selected for priming. . The protective cap 37 is replaced by a casing part 38 which is arranged on the casing part 4 and snapped onto the casing part. The casing part 38 is fitted with a needle protection part 39, preferably in the form of a needle protection sleeve, so that the needle protection part can move elastically in the direction opposite to the advance direction V. When injection is performed with an injection needle (not shown), the needle protection unit 39 repels and enters the casing portion 38 in the direction opposite to the forward direction V. In the opposite movement, the needle penetrates through the end opening of the needle protector 39.

  13 and 14 show the coupler engagement area in detail. In this case, FIG. 13 shows a disconnected state, and FIG. 14 shows a connected state. Unlike the embodiment according to the first example, the engagement elements 6a, 7c between which the coupler engagement state is established exhibit an inclination angle with respect to the forward direction V. In an exemplary embodiment, each of the engagement elements 6a, 7c is formed in the form of a conical toothed ring that surrounds the threaded axis of the piston rod 15, and the coupler input member 6 'is inwardly connected to its distal end. The engaging element 6a is formed as a cone, and the coupler intermediate member 7 'forms an engaging element 7c as an outer cone at its proximal end. The conical engagement areas are in positions that coincide with each other and are directly opposite each other in the axial direction towards a clear distance X. Instead of a conical shape, the coupler region may have a matching convex / concave shape.

  Unlike the embodiment according to the first example, the coupler intermediate member 7 'can move in the axial direction and the coupler output so that the coupler intermediate member is fixed so that it does not rotate at any axial position. The member 9 is engaged. The coupler intermediate member is again formed as a sleeve portion and is attached to the coupler output member 9 so that the intermediate member can slide in the axial direction. For this purpose, the coupler intermediate member penetrates into the coupler sleeve 8 ', which is accordingly slit in the axial direction, which cannot be seen in the drawing. It is formed in a state in which the connection state, which is rotatably fixed via the engagement element formed as a linear tooth portion in the axial direction, is securely locked. The return member 10 ′, which is the same as the first example embodiment and the embodiment and attached state, but whose function is reduced, is in tension between the coupler output member 9 and the coupler intermediate member 7 ′. The coupler intermediate member is loaded with an elastic force in a direction opposite to the forward direction V. As shown in FIG. 13, when the coupler input member 6 ′ is in the disconnected state in which the coupler input member 6 ′ is retracted from the coupler intermediate member 7 ′ in the opposite direction to the forward direction V, the return member 10 ′ pushes the coupler intermediate member 7 ′. The engaged state is fixed so as to be rotatable with the connection release member 11 ′. Corresponding engagement elements are likewise denoted as reference numbers 7a, 11a. The engaging elements 7a, 11a are also formed as conical toothed rings. The engagement state between the coupler intermediate member 7 ′ and the connection release member 11 ′ may be a pure friction locking state instead of this. In this case, the engagement elements 7a, 11a are provided with matching friction areas facing each other. In an example embodiment, these will be conical regions facing each other.

  There is another modification of the dosage setting member 18 '. Unlike the dosage setting member 18 of the embodiment according to the first example, the dosage setting member 18 ′ is relative to the casing part 4 in the direction X of movement of the coupler, in the example embodiment, in the axial direction. It cannot be moved. Instead, the coupler input member 6 ′ is connected to the dosage setting member 18 ′ so that it can be moved axially while again being fixed so that the coupler input member does not rotate. When the drive member 5 and the piston rod 15 are disconnected, there is an engagement state that is rotatably fixed between the coupler input member 6 ′ and the dosing member 18 ′. This engaged state is released in the course of the coupler stroke X, i.e. just before the rotationally fixed connection between the coupler output member 9 and the casing part 4 is released. Due to this engaged state, the coupler input member 6 ′ and the dosing member 18 ′ are provided with engagement elements 6 b, 18 a, which are two members 6 in the form of grooves and springs. ′ And 18 ′ are formed on the shell region in the radial direction so as to face each other. 11 and 12 can also be referred to regarding the rotationally fixed connection between the coupler input member 6 'and the dosing member 18'. There is a connection state that is rotatably fixed in the connection release state shown in FIG. 11, and this connection state is released in the connection state shown in FIG.

  Another difference with respect to the embodiment according to the first example exists with respect to the holding means. In the embodiment according to the second example, the return member 10 ′ has no effect of separating the coupler members 6 ′ and 9 from each other. The holding means of the embodiment according to the second example has a return member 14, a support structure 6c, and a dosing member 18 '. The return member 14 is loaded on the coupler input member 6 ′ with an elastic return force via the support structure 6c, and this elastic return force reacts with the movement X of the coupler of the coupler input member 6 ′. In an exemplary embodiment, in the direction of the coupler movement X that coincides with the forward direction V, the return member 14 is supported on a dosage setting member 18 'forming a support collar for this purpose. . The support structure 6c is connected to the coupler input member 6 ', which cannot move in the direction of the coupler movement X or in the opposite direction. The support structure is formed as a short sleeve having an outer flange on which the return member 14 is supported. The support structure 6 c abuts against the casing part 4 in the direction opposite to the direction of the movement X of the coupler. The movement X of the coupler moves the coupler input member 6 ′ against the elastic return force of the return member 14 to bring the coupler intermediate member 7 ′ into the coupler engagement state. As in the embodiment according to the first example, the return member 14 is formed as a pressure spring loaded with pressure in the direction of the movement X of the coupler.

  The mode of operation of the modified couplers 6 'to 11', 14 'is the same as the coupler of the embodiment according to the first example. In this way, in the disconnected state, the coupler output member 9 is connected to the casing portion 4 via the coupler sleeve 8 ', the coupler intermediate member 7' and the connection releasing member 11 'so as to be fixed so as not to rotate. . By operating the injection button 16 and then executing the coupler stroke X (FIG. 11), in the embodiment according to the second example, the coupler engagement between the coupler input member 6 ′ and the coupler intermediate member 7 ′. A general state is established. In the first stage of the coupler stroke X, the engaging elements 6a, 7c are locked together and the coupler input member 6 'is connected and does not rotate via the coupler intermediate member 7' and the coupler sleeve 8 '. The coupler output member 9 is connected in such a fixed state. Only when the rotationally fixed engaged state is established is the coupler intermediate member 7 ′ disengaged from the release member 11 ′ by the coupler input member 6 ′ pushed in the forward direction V. The coupler output member 9 is free to rotate about the threaded axis R formed with respect to the piston rod 15, and the coupler engagement is fully established.

FIG. 14 shows the injection device in its connected state, ie, in the coupler engaged state.
FIGS. 15 and 16 correspond to FIGS. 6 and 7 of the embodiment according to the first example, and thus can be referred to.

  FIG. 17 shows the injection device according to the second embodiment when the reservoir 2 is replaced. As shown in FIG. 16, when the reservoir 2 is empty, the casing part 1 is removed from the casing part 4. This moves the connection release member 11 'to the connection release position. This function corresponds completely to the function of the connection release member 11 of the embodiment according to the first example, so that reference can be made to the embodiment according to the example and the description relating to FIGS. .

  When in the state shown in FIG. 17, the casing part 1 has already received a new reservoir 2. In order to connect the casing part 1 with the casing part 4, the casing part 1 can be moved towards the casing part 4 using a piston 3 that seals the reservoir 2 in the proximal direction. The piston rod 15 protruding freely from the casing part 4 is returned by the pressure piston 3 and is in a threaded engagement with the coupler output member 9, which can rotate freely but is fixed in the axial direction. Is done. In an embodiment according to the second example, a piston rod 15 is provided for a rotatably fixed linear guide 4a formed by a coupler receiver inserted into the casing part 4 so as to be fixed against rotation. When retracted, it completes an axial linear movement, while the coupler output member 9 rotates freely with the coupler sleeve 8 'about a common threaded axis. Instead of moving the piston rod 15 back and pressurizing the piston 3, the piston rod 15 may be moved back in advance by pushing its plunger directly.

  FIG. 18 shows the coupler region in detail with the connection release member 11 ′ in the connection release position. The function of the decoupling member 11 ′ corresponds to the function of the embodiment according to the first example, ie, the coupler input member 6 ′ is blocked at the retracted axial position.

  The dosage setting movement and the driving movement are also introduced into the gear of the dosage display 20 ′ via the coupler input member 6 ′ and the display coupling member 22 in the embodiment according to the second example. The display coupling member 22 is fixed so that the display coupling member does not rotate and cannot be moved relative to the casing part 4 in the direction of the coupler movement X and in the opposite direction. Connected.

  FIGS. 19 to 24 show an embodiment according to a third example of the injection device, in which case the driving force for discharging the preparation during administration is not applied manually, and the driving spring Is applied by a drive member 25 formed as The drive member 25 is tensioned by setting the dosage to be administered. The spring energy absorbed when setting the dosage is released when the device is triggered and converted to advance the piston rod 15.

  FIG. 19 shows that the assembled casing part 38 and the needle protection part 39 received in the casing part 38 are completed and slide in the opposite direction to the forward direction V against the force of the return spring. An injection device of an embodiment according to a third example made possible is shown.

  20 and 21 show the casing part 4 in which the components of the injection device are received. FIG. 20 is in a resting state equivalent to the embodiment according to the previous example in which the dosage can be set, and FIG. 21 is in the coupler engaged state. Unless specifically described otherwise, the following description will be made with particular reference to FIGS.

  The drive member 25 is a spiral spring that acts as a torsion spring including a spring winding that surrounds the threaded axis R in a threaded engagement state between the coupler output member 9 and the piston rod 15. The spring windings are arranged so that one is on the other in the radial direction relative to the threaded axis R. These spring windings exhibit a zero pitch with respect to the threaded axis. The inner end of the spring winding is fastened to the coupler input member 6 ′, the outer end is fastened to the support structure 26 connected to the casing part 4, and the outer end is not moved in the direction of the coupler movement X. Yes, but fixed to prevent rotation. On the other hand, the support structure 26 is connected to the coupler input member 6 'so that the support structure cannot move in the direction of the coupler movement X and in the opposite direction. The coupler input member 6 ′ can rotate relative to the support structure 26 about the threaded axis R. Another support structure 6d is connected to the coupler input member 6 'so that the support structure cannot move in the direction of the coupler movement X and in the opposite direction. In an example embodiment, the coupler input member 6 'and the support structure 6d are integrally formed. The drive member 25 is surrounded by the support structures 6d and 26 in the axial direction.

  The function of the coupler corresponds to the function of the embodiment according to the second example, and the same reference numerals are used for the coupler members 6 'to 10' and the decoupling member 11 '. However, unlike the coupler of the embodiment according to the second example, the coupler sleeve 8 'in the embodiment according to the example is omitted. The coupler intermediate member 7 ′ is in direct engagement with the coupler output member 9, which transmits the rotational driving movement of the coupler input member 6 ′ to the coupler output member 9.

  Reference numeral 20 ″ denotes a dosage display connected to the coupler input member 6 ′ via the display connecting member 23, and the dosage display is a display connecting member according to another embodiment described above. Like 21 and 22, the dosage display is connected to the coupler input member 6 'so that it is fixed against rotation. The display connecting member 23 cannot move relative to the casing part 4 in the direction of the coupler movement X and in the opposite direction. As in the embodiments according to the first and second examples described above, there is a connection state in which the display connecting member 23 is rotatably fixed in both the connection release state and the connection state of the apparatus.

  In order to set and store the dosage, between the coupler casing 6 'and the casing part 4 to prevent the rotational driving movement of the coupler input member 6' and to keep the drive member 25 in its tensioned state. A rotating block state is formed. At the holding position of the illustrated coupler members 6 ′, 7 ′, 9, a rotating block state exists between the first block member 24 and the second block member 34. The block member 24 is connected to the coupler input member 6 'so that the block member is fixed so as not to rotate. The block member 34 is fixed so that the block member does not rotate, but the casing can move relative to the casing part 4 and the coupler input member 6 ′ in the direction of the coupler movement X and in the opposite direction. Connected with part 4. The facing areas of the block members 24, 34 that contact each other in block engagement form a ratchet that allows rotational movement of the coupler input member 6 ′ that tensions the drive member 25 and in the opposite direction. Prevents turning motion.

  In FIG. 24, the block member 24 attached to the coupler input member 6 ′ to be fixed so as not to rotate, and the display connecting member 23 connected to the coupler input member 6 ′ so as to be fixed not to rotate are moved. The coupler input member 6 'is shown together with the connecting portion 33 connected to the input member 6' so that it cannot. The display connecting member 23 forms a 1's counting ring of the dosage display 20 ″ and is appropriately connected to the 10's counting ring to display the set dosage. On the side facing the base end direction facing the block member 34, the block member 24 is provided with block tooth portions 24 a arranged uniformly around the axis R. The block tooth portion cooperates with the counterpart tooth portion of the block member 34 in the block engagement state, and forms a rotation block portion for the driving movement. A screw portion 24b is provided in the outer region of the shell of the block member 24 for the second function related to the setting and discharge of the dosage. The threaded axis of the threaded portion coincides with the threaded axis R of the piston rod 15. The stop member 27 engages with the screw portion 24b. The stop member 27 is guided in an axial groove in the inner shell region of the casing part 4 in an exemplary embodiment so that the stop member can move linearly parallel to the threaded axis R. Is done. The block member 24 forms a rotation stopper 24 c of the stop member 27. The rotation stopper limits the movement of the coupler input member 6 ′ that moves the piston rod 15 forward. The rotary stopper forms another rotary stopper 24d for the stop member 27 that determines the maximum dosage that can be dispensed and set. Another stop member 27 is arranged on the side of the threaded axis R opposite the stop member 27 which can be seen in the view of FIG. 23 and in the same manner as the other two rotation stoppers 24c, 24d. Collaborate. The threaded portion 24d is double screwed. The stop member 27 simultaneously abuts against the respective assigned rotation stoppers 24c and 24d, as can be seen in the sectional view of FIG. 23 with respect to the rotation stopper 24c. The rotation stopper 24c determines the zero dosage position, and the rotation stopper 24d determines the maximum dosage position.

  In the embodiment according to the third example, the holding means according to the third modification is formed. The holding means includes a return member 19, a display connecting member 23, and a block member 24. The return member 19 is supported on the casing part 4 via the display connecting member 23 in the direction of the coupler movement X, and is supported on the block member 24 in the direction opposite to the coupler movement X. ing. The return member 19 presses the block member 24 until the return member abuts against the connection portion 33. The connecting part 33 is connected to the coupler input member 6 ′, which cannot be rotated in the direction of the coupler movement X and in the opposite direction, so that the return member 19 is connected to the coupler An elastic restoring force acting in the direction opposite to the direction of the coupler movement X is applied to the input member 6 ′ via the block member 24 and the connecting portion 33. The elastic return force holds the coupler input member 6 'in the holding position retracted from the coupler engagement state. The return member acts similarly as a pressure spring. The block member 24 connects the two shells, the outer shell forming the screw portion 24b, the inner shell serving to be attached to the coupler input member 6 'that is fixed so as not to rotate, and the two shells. A sleeve portion including a base portion on which a block tooth portion 24a is formed. The return member 19 is thus cup-shaped and protrudes into the block member 24 supported by the base of the block member 24.

  The return member 19 pushes the block member 24 not only until the block member abuts against the connection portion 33 but also until the block member abuts against the casing portion 4. Such abutting by other methods prevents the block member 24 from moving beyond the holding position shown in FIG. 20 in the opposite direction to the movement X of the coupler. In this way, the block member 24 can move relative to the coupler input member 6 ′ in the direction of the coupler movement X against the return elastic force of the return member 19. On the contrary, the coupler input member 6 ′ can move in a direction opposite to the direction of the coupler movement X with respect to the block member 24 abutting against the casing portion 4.

  The balance spring 17 tensioned between the piston rod 15 and the connecting portion 33 supports the return member 19 in terms of its function of holding the coupler input member 6 'in the holding position. The balance spring 17 can in principle be replaced by a return member 19 that retracts the coupler members 6 ′, 7 ′, 9. However, preferably, when the balance spring is at least partially relaxed, the spring can no longer hold the coupler members 6'-9 in the holding position and is therefore no longer with sufficient certainty. The coupler is weak enough that the coupler cannot be held in the disconnected state.

  A trigger element 28 is provided for triggering the drive member 25. The trigger element 28 can move parallel to the casing part 4 in the direction of the coupler movement X (the forward direction V and / or the distal direction in the exemplary embodiment), and the coupler input member It can rotate around the 6 'rotation axis R. The rotation axis R coincides with the threaded axis R of the piston rod 15 in the embodiment according to the example. The trigger element is guided by the casing part 4 in these two movements. The translational movement in the distal direction establishes a coupler engagement between the coupler input member 6 'and the coupler intermediate member 7' and releases the rotating block between the block members 24, 34. Then, the drive member 25 is triggered, that is, discharging is performed. For this reason, the movement that translates in the forward direction V is also referred to as a trigger movement in the following description.

  In another function, the trigger element 28 forms the dosing member of the embodiment according to the third example. The rotational movement of the trigger element 28 relative to the casing part 4 via a number of intermediate members sets the dosage of the formulation that can be dispensed by the next dispensing process. This movement is referred to as a dosage setting movement in the following description. From the zero dose position determined by the stop member 27 shown in FIG. 20 and determined by the stop member 27 in contact with the rotation stopper 29c of the block member 24 that restricts the driving movement of the coupler input member 6 ', the rotation direction of the indicated arrow, that is, the dose The dosage can be set by turning the trigger element 28 in the direction. The rotational dosage setting movement of the trigger element 28 is transmitted via the inner part 29 to the coupler input member 6 ', which is connected to the trigger element 28, which rotates and does not displace. The rotational dosage setting movement is transmitted to the connecting portion 33. For transmission, the inner part 29 and the connection part 33 are in engagement with each other so as to be fixed against rotation, and the connection part 33 is coupled with the coupler input member 6 'so that the connection part is fixed against rotation. Connected with. In order to be fixed against rotation, the inner part 29 and the connection part 33 have an inner tooth part 29a and an outer tooth part 33a that can be locked together and displaced axially with each other in the rest state of the device. And are provided.

  The trigger element 28 is disposed in the proximal region of the casing portion 4 so that it is easy for the user to use. Its outer sleeve part surrounds the casing part 4. The base of the trigger element 28 forms the proximal end of the injection device. To set the dosage, the trigger element 28 can be operated as a rotary button and a rib is provided in its outer shell region for this purpose. To trigger, the trigger element can be operated as a push button. During the dispensing movement, the trigger element 28 locks against the casing part 4 at a separate rotational angular position corresponding to the one's dosage.

  The stopper element 29 b facing the region facing the proximal direction of the connecting portion 33 protrudes radially inward from the inner portion 29. When the device is at rest, a clear distance remains between the connecting part 33 and the stopper element 29b. The clear distance is such that during the triggering movement of the trigger element 28, the inner part 29 and the connecting part 33 before the end of the relative movement of the triggering element 28 relative to the connecting part 33 by the abutment of the stopper element 29b. Long enough to be just enough to allow the rotating block state between to be released.

  The second block member 34 is tensioned in a block engagement state with the block member 24 by the block spring 31. For this purpose, the block spring 31 is supported by the block member 34 in the direction of movement X of the coupler and is opposite to the direction of movement X of the coupler in the casing part 30 fixedly connected to the casing part 4. Supported in the direction. Another spring 32 disposed between the inner portion 29 and the block member 34 tensions the trigger element 28 against the block member 34 to a proximal position. The block member 34 is guided in the axial direction by the casing part 4 so as to be fixed against rotation. The casing portion 4 forms a distal side and proximal side stopper for the mobility of the block member 34.

  In the resting state shown in FIG. 20, the user sets the dosage by turning the trigger element 28 in the dosage setting direction. During this rotational dosage setting movement, the trigger element 28 follows the connection part 33 via the anti-rotation block parts 29a, 33a, and the connection part 33 for a part thereof causes the coupler input member 6 'to move. As a result, the coupler input member completes the same rotational dosage setting movement as the trigger element 28. When the coupler input member 6 'is turned, the drive member 25 is tensioned. The stop member 27 is engaged with the screw portion 24b of the block member 24, and moves from the stopper 24c of the screw portion 24b that determines the zero dose toward the stopper 24d that determines the maximum dose (FIG. 24). To do.

  The injection device also provides a convenient way to modify the dosage, as will be apparent by comparing FIG. 20 and FIG. If the user accidentally sets an excessively large dosage, the user can modify the dosage by turning the coupler input member 6 'back. To modify the dosage, the user pulls the trigger element 28 proximally. This backward movement of the trigger element 28 is indicated by an arrow in FIG. 22 as the correction rotation direction. When the device is in a rest state, the inner portion 29 and the block member 34 are in a driven engagement with respect to proximal movement. Corresponding follower means are indicated as reference numbers 29c, 34a. The follower member 29c formed by the inner portion 29 and the follower means 34a formed by the block member 34 grip the back of each other and form a latch portion for the backward movement of the trigger element 28. In this way, when the trigger element 28 is pulled, the block member 34 also moves in the proximal direction against the force of the block spring 31, thereby blocking the block member 24 with the block member 24 that contacts the casing portion 4. Release from the combined state. As soon as the rotating block state is released, the user is able to rotate in a reverse direction of the trigger element 28 and still in a rotationally fixed engagement state which still exists between the inner part 29 and the connecting part 33. To correct the dosage. As soon as the user releases the trigger element 28, the trigger element snaps back together with the block member 34 due to the effect of the block spring 31. For this reason, the block member 34 moves in a snap shape and returns to the block engagement state with the block member 24. During the counter-rotating movement, the user continues to conveniently hold the trigger element 28, which is facilitated by the rotational locking angular position of the trigger element 28. However, in principle, the user can also snap the trigger element back as required and set the dosage again.

  Once the desired dosage is set, the device is placed on the skin at the desired administration location and injected with a needle. For injection with the injection needle, the trigger element 28 serves another function, and for this purpose, the trigger element is connected to the needle guard 39 (FIG. 19).

  In the first injection phase, the user presses the injection device against the skin, causing the needle guard 39 to move distally relative to the casing portion 38. However, the first movement portion of the needle protector 39 does not yet expose the injection needle. The tip remains stopped in front of the needle protector 39. At this stage of the first injection process, the needle guard 39 abuts against the resistance element and the needle guard cannot be moved further in the distal direction with respect to the casing part 38. While continuing to apply pressure to the injection device toward the skin, the user pushes the trigger element 28 proximally. In the course of this first stage of the trigger movement, the trigger element 28 releases the abutting contact state between the needle protector 39 and the resistance element, and the needle device and, together with this, the skin of the injection needle. It moves with respect to the direction of the needle protector 39 and injects with the injection needle. Regarding the function of the trigger element 28 for injection with a needle, it was filed by the applicant on the same filing date as “Attachment module for an with an engagement control for the element covering the needle. Reference is made to a patent application specification entitled “Injection Device Compiling an Engagement Control for a Needle Covering Element”.

  Once the injection needle is placed subcutaneously, the formulation can be dispensed immediately by releasing the drive member 25 and further pushing the trigger element 28. In the second stage of the triggering movement of the triggering element 28 following the injection stage, the triggering element 28 and thus the inner part 29 is further pushed in the distal direction against the connection 33 against the pressure of the spring 32, the rotating block 29a, 33a is released. The trigger element 28 can rotate in the idling state. As soon as the rotating block portions 29a and 33a are released, the stopper element 29b advances to the contact state with the connecting portion 33. In the third stage of the subsequent trigger movement, the trigger element 28 pushes the connecting part 33 and thus the coupler input member 6 'in the direction of the coupler movement X via the stopper element 29b. This direction is the forward direction V in the exemplary embodiment. Due to the effect of the spring force of the block spring 31, the block member 34 follows this movement until the block member abuts against the casing part 4. Before the block member 34 reaches the contact position, the coupler input member 6 ′ is in a coupler engagement state with the coupler intermediate member 7 ′. The coupler input member 6 ′ pushes the coupler intermediate member 7 ′ so that the coupler input member 6 ′ is released from the friction locking block state with the release member 11 ′ against the force of the return member 10 ′. The block engagement between the conical regions of the two members 7 ′, 11 ′ is released, so that the block member 34 abuts the casing part 4 when the coupler engagement is fully established. In the final stage of the subsequent trigger movement, the trigger element 28 pushes the block member 24 so as to be released from the block engagement state with the block member 34 via the connection portion 33.

  As soon as the rotating block state formed by the block members 24 and 34 is released, the driving force of the driving member 25 starts the rotational driving of the coupler input member 6 'and via the coupler engagement state It is transmitted to the coupler output member 9. Since the piston rod 15 is guided in the linear guide portion 4a so as to be fixed so as not to rotate, the piston rod 15 moves toward the forward direction V in the threaded engagement state with the coupler output member 9, and the formulation Is discharged. This discharge movement is terminated when the stopper 24c of the dosage setting member 24 for determining the zero dosage portion and the stop member 27 come into contact with each other.

  FIG. 21 shows when a zero dose or a small amount of priming dose is set in the connected state after the rotating block parts 24, 34 have been released, i.e. after the triggering element 28 has fully triggered. An injection device is shown. Desirably, if pressure is continuously applied to the trigger element 28, the trigger sequence described above should proceed automatically until the dosage set is completely dispensed from the injection.

  FIG. 23 shows the injection device after the container 2 is emptied. The casing part 1 has already been removed from the casing part 4. The piston rod 15 takes the position of the most distal side. The disconnection member 11 ′ blocks the coupler input member 6 ′ at a position retracted from the coupler intermediate member 7 ′. The function of the connection release member 11 ′ corresponds to the function of the embodiment according to another example. However, unlike the embodiments according to the two first examples, the casing part 1 and the connection release member 11 ′ are not directly connected but are in a state of being guided and engaged via the adapter structure 36. The adapter structure 36 is a sleeve in the casing part 4 which is fixed in the connecting part in the direction X of the coupler movement and in the opposite direction, this sleeve being the longitudinal central axis R of the casing part 4. Can be rotated around. The adapter structure 35 forms a guide bend 36a as a cavity or tear in its shell region facing the uncoupling member 11 '. The guide curved portion 35a indicates the route of the threaded portion. The length measured at the circumference and the pitch of the guide curve portion 35a measured with respect to the longitudinal central axis of the casing part 4 is such that the adapter structure 35 rotates by a quarter of a rotation or 2 with respect to the connection release member 11 ′. It is dimensioned so that the connection release member 11 'moves to the connection release position shown in FIG. In order to cause the movement in the axial direction, the connection release member 11 ′ is engaged with the guide bending portion 35 a via the engagement element 12. In this respect, reference is made to the description of the embodiment according to the first example.

  When connecting the casing parts 1, 4, the adapter structure 35 forms a linear guide for the casing part 1. The casing part 1 is inserted into the adapter structure 35, and there is preferably a slight friction locking state, and correspondingly there is a sliding guide state with respect to the casing part 1. The casing part 1 cannot be rotated relative to the adapter structure 35 about the longitudinal central axis of the casing part 4. Just at the start of the insertion of the casing part 1 into the adapter structure 35, this establishes a rotationally fixed engagement. When inserted until the casing part 1 abuts against the casing part 4, i.e. when the coupler is received at location 4a, the casing 1 rotates relative to the casing part 4 during this rotational movement, The adapter structure 36 is driven until the engagement element 12 of the connection release member 11 ′ comes into contact with the end of the guide bending portion 36 a. The rotational movement of the casing part 1 is preferably not possible until it reaches its axial contact position. For this purpose, the rotating block part that acts until the contact position is reached between the casing parts 1, 4. Can be formed.

  The movement of the disengagement member 11 ′ caused when the guide is engaged exhibits an axial length that is longer than the full coupler movement length X. In the connection release movement, the connection release member 11 ′ pushes the coupler input member 6 ′ beyond its holding position taken in the rest state, and blocks the coupler input member at the connection release position. The coupler input member 6 ′ drives the trigger element 28 via the stopper element 29 b by this forced release operation. Through the latch between the follower means 29c and 34a, the block member 34 is also driven against the force of the block spring 31 and moves so as to be released from the block engagement state. Since the block member 24 is in contact with the casing portion 4, the block member cannot follow the block member 34. As described above, when the casing parts 1 and 4 are removed, the rotating block state is released by the connection release mechanism formed by the casing parts 1 and 4 together with the connection release member 11 ′ via the adapter structure 35. If the coupler input member 6 'is not yet in the zero dose position, the coupler input member is finally rotated to the zero dose position by the drive member 25 and the dose display 20 "is zeroed. In this regard, once again reference can be made to the particularly advantageous effect of the connection between the dosage display 20 '' and the coupler input member 6 ', i.e. each time it is dispensed, the dosage display 20' ' , Reset according to the dispensed dose. At some point, for example, if the set dosage is not dispensed because the injection process is stopped or the container 2 no longer holds a fully set dose, the user Can be read from the dosage display 20 ″, at which time the dosage display is only partially reset.

It is a perspective view which shows the injection apparatus of embodiment by a 1st example. FIG. 6 is a longitudinal sectional view of the injection device with the coupler open. FIG. 6 is a view of an injection device with the coupler closed. FIG. 3 is a detailed view of FIG. 2. FIG. 4 is a detailed view of FIG. 3. It is a figure of the injection apparatus after a dosage is set. FIG. 4 is a view of the injection device after the reservoir is empty. It is a figure of the connection release member and casing part of an injection device. FIG. 4 is a view of the distal portion of the injection device with the casing portion connected. FIG. 6 is a view of the end portion while the casing portion is removed. FIG. 6 is a longitudinal sectional view showing an injection device according to an embodiment of the second example in which the coupler is open. FIG. 6 is a different longitudinal section through an injection device according to a second example embodiment with the coupler closed. FIG. 12 is a detailed view of FIG. 11. FIG. 13 is a detailed view of FIG. 12. It is a figure of the injection apparatus of embodiment by the 2nd example after a dosage is set. FIG. 4 is a diagram of an injection device of an embodiment according to a second example after the reservoir is emptied. FIG. 6 is a view of an injection device of an embodiment according to a second example with casing parts removed from one another. FIG. 18 is a detailed view of FIG. 17. It is a figure of the injection apparatus of embodiment by a 3rd example. FIG. 7 shows a proximal end portion of a third example embodiment of the injection device with the coupler open. FIG. 9 shows an injection device according to a third example embodiment with the coupler closed. It is a figure which shows the proximal end part of the injection apparatus of embodiment by the 3rd example when correcting dosage. It is a figure which shows the base end part of the injection apparatus of embodiment by the 3rd example after a reservoir is emptied. It is a figure which shows the block member and stop member of embodiment by a 3rd example.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 1st casing part 1a Guide curve part 2 Container 3 Piston 4 2nd casing part 4a Linear guide part 4b Linear guide part 4c Peripheral guide part 4d Fixing element 4e Axial guide part 5 Drive member 6, 6 'Coupler input member 6a engagement element 6b engagement element 6c support structure 6d support structure 7, 7 'coupler intermediate member 7a engagement element 7b engagement element 7c engagement element 8, 8' coupler sleeve 8a engagement element 9 coupler output member 10 Coupler return member 11, 11 ′ Release member 11 a Engagement element 12 Engagement element 13 Fixing element 14 Coupler return member 15 Piston rod 15 a Disc 16 Trigger element 17 Balance spring 18, 18 ′ Dosage setting member 18 a Engagement element 19 Coupler return member 20, 20 ′, 20 ″ Dosage display 21 Display connection member 22 Display connection Member 23 display connecting member 24 first block member 24a block tooth portion 24b screw portion 24c rotation stopper 24d rotation stopper 25 driving member 26 support structure 27 stop member 28 trigger element 29 inner portion 29a tooth portion 29b stopper element 29c driven means 30 Casing part 31 Block spring 32 Spring 33 Connection part 33a Tooth part 34 Second block member 34a Follower means 35 Adapter structure 35a Guide curve part 36-
37 Protection cap 38 Casing part 39 Needle protection part

Claims (34)

In an administration device for administering a fluid formulation,
a) a casing (1, 4) comprising a reservoir of the formulation;
b) preparation transport means (3, 15);
c) a coupler input member (6 ') capable of driving around the rotational axis (R) coinciding with the longitudinal axis of the transfer means (3, 15) to drive the transfer means (3, 15);
and d) are fixed against rotation by the first block member connected to the coupler input member (6 ') (24),
e) When the first block member (24) is releasably rotationally engaged, the first block member (24) is prevented from rotating in the driving direction , and the first block member (24) ) and the second block member to permit rotational movement of the opposite dosing direction of the driving direction (34),
f) First, when the second of the two blocks member (24, 34) is in the rotation preventing engagement is tensioned by the rotational movement, and, after the rotation preventing engagement is released, the coupler input member ( 6 ') and a torsion spring (25) connected to the coupler input member (6') to drive the rotation;
Trigger trigger movements of g) the triggering element (28) is coupled said at least one of the two block members (24) and to move so as to get out of the rotation preventing engagement at least one blocking member (24) An element (28),
h) the triggering element (28) forms a dosing setting member for setting a dosage amount of the formulation,
i) A dosing device in which a torsion spring (25) is wound around said axis of rotation (R) and has a zero pitch relative to said axis of rotation . The apparatus according to claim 1, the coupler input member for driving the transfer means (3, 15) (6 ') can be moved such that the coupler engagement by coupler exercise (X), rotation preventing engaged state, characterized in that it is released by exercise of the coupler (X), device. The apparatus according to claim 2, exercise of the coupler (X) is characterized by an axial movements of the axis of rotation (R), device. The apparatus according to claim 2 or 3, the coupler input member (6 ') during the coupler movements to release the rotation-inhibiting engagement (X), wherein one of the two block members (24) A device characterized in that it is driven. The apparatus according to any one of claims 1 to 4, the triggering element (28) triggers exercise is causing Coupler exercise (X) of the coupler input member (6 ') of the coupler engagement, in the coupler engagement, so that the driving force of the torsion spring (25) can be transmitted to the transfer means through the coupler input member (6 ') (3,15), the triggering element (28) is a coupler input member Device connected to (6 '). The apparatus according to claim 5, the triggering element (28) is characterized in that to the driven trigger luck Dochu coupler input member (6 '), device. The apparatus according to any one of claims 1 to 6, the coupler input member (6 ') is connected to the rotating shape to the transport means in the trigger luck first stage dynamic (3,15), the trigger at the exercise second stage, during which there is connection state between the coupler input member (6 ') and the transfer means (3, 15), the rotation preventing engagement of the two block members (24, 34) Characterized in that the device is released. The apparatus according to claim 2 or 5, the second block member (34) is characterized in that it can be moved in the direction of the coupler exercise (X), device. The apparatus according to any one of claims 1 to 8, the block spring (31) has a feature that the in rotational blocking engagement by tension of one of the two block members (24, 34) Do the equipment. The apparatus according to claim 9, the block member (31), characterized in that acting on the second block member (34) in the direction of the coupler exercise (X), device. 11. A device according to any one of the preceding claims, wherein the coupler input member (6 ') performs a rotational movement to set the dosage in the dosage setting direction when the dosage of the formulation is set. A device characterized by that. Coupler The apparatus according to claim 11, the triggering element (28), when the dosage amount of the formulation is set, executes the dose setting exercise, and, by the dosage setting movements of the triggering element (28) A device characterized in that it is connected with a coupler input member (6 ') so that a rotational movement for setting the dosage of the input member (6') occurs. The apparatus according to claim 12, the triggering element (28) is fixed to the trigger element does not rotate and is connected to the coupler input member (6 '), and sets the dosage amount of the formulation, device . 14. The device according to claim 12 or 13, wherein the connection between the trigger element (28) and the coupler input member (6 ') is releasable for setting the dosage of the formulation. A device characterized by. Device according to any one of claims 11 to 14, rotational movement to set the dosage, increase the value of the dosage amount to be displayed so that the dosage amount display (20 '') is a coupler input member ( 6 '), connected to the device. Device according to any one of claims 11 to 15, to reduce the value of the dosage amount for the driving direction of the movements of the coupler input member (6 ') is displayed so that the dosage amount display (20'') Is connected to the coupler input member (6 ').   17. The device according to claim 1, wherein the torsion spring (25) comprises an inner spring winding and at least one outer spring surrounding the inner spring winding over at least part of its circumference. A device, characterized in that it is a spiral spring wound around an axis of rotation (R). The apparatus according to claim 17, torsion end of the spring (25), preferably the inner edge, characterized in that it is fixed against rotation by being connected with the coupler input member (6 '), device. Device according to claim 2 or 5, wherein a torsion spring (25) is attached to the coupler input member (6 ') , the torsion spring (25) being at one end, preferably at the outer end, of the support structure (26). is supported by the upper, said support structure, and wherein Tei Rukoto fixed against rotation at about the coupler input member driven by the exercise (X) of the coupler (6 ') and the rotational axis (R) Do the equipment. The apparatus according to claim 2 or 5, a torsion spring (25), movements in a direction to the coupler input member (6 ') without applying a force or couplers coupler exercise (X) direction of the (X) A device characterized by applying a force acting in the opposite direction. 21. A holding means (19, 23, 24) for holding a coupler input member (6 ') in a holding position released from the transfer means (3, 15) according to any one of the preceding claims. ). Device according to claim 2 or 5, comprising holding means (19, 23, 24) for holding the coupler input member (6 ') in the holding position released from the transfer means (3, 15), holding means (19,23,24) includes a return member (19), the return member (19), the coupler input member in elastic restoring force acting in the opposite direction of the coupler exercise direction (X) ( 6 '). The device of claim 22, the return member (19), characterized in that it is supported on the first block member in the opposite direction of the movements of the coupler (X) (24), device. The device according to any one of claims 1 to 23, for modifying the dosage amount, the triggering element (28) is retracted movements to release the rotation-inhibiting engagement of the blocking member (24, 34) It can be run, and while the rotation preventing engagement is released, after being released, the triggering element (28), the trigger element and the first block member is fixed against rotation (24) A device characterized by being connected. The apparatus according to claim 24, the triggering element (28), as the second block member (34) moves to get out of the rotation preventing engagement by said retracting movements second block member (34) A device characterized in that it is connected to the device. The apparatus according to claim 2 or 5, the coupler input member (6 ') is movable relative to the first block member (24) in the opposite direction of the coupler exercise (X), the return member (19 ) is the first block member (24) loaded by elastic restoring force acting toward the opposite direction of the coupler exercise (X) direction, the casing (1,4) or casing (1,4) The structure connected to the device forms a stopper that reacts against the elastic return force against the first block member (24). 27. The device according to claim 1, wherein the casing (1, 4) comprises a first casing part (1) having a reservoir, a coupler input member (6 ') and both block members ( 24, 34) to which a second casing part (4) is attached, both casing parts (1, 4) being removable from each other, while acting on at least one of both block members (24, 34) Device comprising a decoupling mechanism (1, 4, 11 ', 35) that automatically releases the anti- rotation engagement when both casing parts (1, 4) are removed from each other . 6. An apparatus according to claim 2 or 5, wherein the casing (1, 4) comprises a first casing part (1) having a reservoir, a coupler input member (6 ') and the block members (24, 34). A second casing part (4) to be attached, both casing parts (1, 4) being removable from each other and acting on at least one of the two block members (24, 34). 4) having a connection release mechanism (1, 4, 11 ', 35) that automatically releases the rotation prevention engagement state when they are removed from each other, and the connection release mechanism (1, 4, 11', 35). ) moves the coupler input member (6 ') in the opposite direction of the coupler exercise (X) direction, the coupler input member (6') during the movements of the coupler input member (6 '), the second Block member (34) is a coupler Characterized in that in the opposite direction of the movements (X) direction is connected to the second block member as disengaged from the motion rotation preventing engagement (34), device. 29. The device according to claim 1, wherein the first block member (24) is a first rotation stopper (24c) that limits the rotational movement of the coupler input member (6 ') in the drive direction. Forming the apparatus. 30. The device according to any one of claims 1 to 29, wherein the first block member (24) is a second rotation stopper for restricting the rotational movement of the coupler input member (6 ') in the dosage setting direction. 24d). Device. Apparatus according to claim 29 or 30, the first block member (24) is provided a screw section (24b) is, with respect to the rotation stopper in the course of the rotary movement (24c, 24d) Device having a stop member (27) that abuts and thereby restricts the rotational movement. 32. The device according to any one of claims 1 to 31, wherein the first block member (24) and the coupler input member (6 ') can move relative to each other along the axis of rotation (R), restoring member (19), characterized in that loading the elastic return force in the direction of the second block member (34) to the first block member (24), device.   33. The apparatus of claim 32, wherein the first block member (24) is a sleeve body with a base and the return member (19) is supported on the base and protrudes into the sleeve body. And the device. 6. The device according to claim 2 or 5, wherein the first block member (24) abuts against at least one of the coupler input member (6 ') and the casing (1, 4). until, characterized in that it can move in opposite directions of movements (X) direction of the coupler apparatus.

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