JP4577799B2 - Biological microvibration analysis device and biological diagnosis support device - Google Patents

Description

The present invention relates to clinical data related to biological microvibration detected on the subject's body skin over 8 years of the present inventors, characteristics (distribution) of subject biological microvibration based on the clinical data, and various diseases It was achieved as a result of the examination on the correlation with.
More specifically, bio-vibration, which is a fine physiological vibration detected on the subject's body skin surface, is achieved as a result of studies on the correlation between various diseases based on theories of Oriental medicine and clinical medicine. It was.
The inventors of the present application promoted diligent studies to support non-invasive diagnosis of cancerous diseases, lifestyle-related diseases, etc., regarding pathological conditions, potential sites of diseases (very) early, Furthermore, the development of a device that can be linked to early detection and early treatment has been completed.

[Key terms used in the claims and specification]
[The significance of the term “biological microvibration”]
In the present invention, biological microvibration refers to fine vibration that can be detected on the surface of a constant temperature animal body and is difficult to detect with the naked eye.
This phenomenon was first observed by Rohracher in 1946, and today it is called micro vibration (MV), and at that time the frequency was supposed to be around 10 Hz.
It has been considered to reflect the autonomic nervous function related to body temperature regulation because it is affected by changes in environmental temperature and autonomic nerve agonists, lacks in thermogenic animals, and exists in thermostatic animals.
Microvibration (English notation: Micro Vibration) is commonly used as a technical term among cardiovascular medical professionals.
The term microvibration is usually used in the sense of minute vibrations of the human body, and is generally abbreviated as MV among medical professionals.
In the present invention, for the purpose of distinguishing from micro-vibration generated in an object such as a machine, micro-vibration that can be detected on the surface of a thermostatic animal body and is difficult to detect with the naked eye is called biological microvibration.
In the present specification, hereinafter, biological microvibration is abbreviated as MV.

[Physiological significance of MV]
There are many research presentations on the basics and clinical aspects of microvibration on the body surface that are difficult to detect with the naked eye but are physiologically present. Attempts to apply as one of functional tests have also been developed (Non-Patent Document 3 to Non-Patent Document 9).
Regarding the mechanism of MV generation, there has been an opinion that it has mainly been based on the muscular vibration component and an opinion that it is based on the cardiographic vibration component. .
Here, the cardiogram is a recording of an elastic movement associated with the mechanical activity of the myocardium, and this is generally called a cardiogram (BCG: Ballistocardiography) in the cardiovascular field. What is monitored in the cardiogram is mainly a time-series change in blood, and is often expressed by a waveform called a pulse pressure wave.

Examples of the physiological significance of MV include the following items (1) to (5) (Non-patent Document 5).

<1> The dominant vibration of the ball MV in the awake resting state is a cardiographic vibration component based on the heartbeat, and the dominant vibration component of the ball MV composed of a frequency of 8 to 13 Hz. Increases during the inspiration period of breathing and decreases during the expiration period.

<2> The accelerated changes in MV observed in the case of exercise and mental tension correspond very well to the increase in stroke volume and heart rate, and are considered to be due to increased sympathetic tone.

<3> It is suggested that the inhibitory change of MV observed at the time of eye pressure compression and sleep originates from the increase in vagal nerve tone from the fact corresponding to the decrease in heart rate and stroke volume.

<4> The promotion and suppression of dominant vibration of the thumb ball MV are closely related to the promotion and suppression mechanism of so-called cardiac function regulation.

<5> The dominant vibration group interval of MV is determined by the change in heart rate.

[The significance of the term "keikeitsu"]
In this application, an acupuncture point is a so-called acupoint that is reported in the Oriental medicine classics as a key point that expresses the disease state of a patient in detail, and that there are 361 places in the human body.
In classics, there are figures that define this not only in the human body but also in dogs and horses.
Recently, in accordance with the World Health Organization (WHO) medical term standardization measures, the World Health Organization has been given an international standard name consisting of a combination of alphabets and numbers for 361 acupuncture points related to the human body.

[Significance of the term “Kei”]
In the present application, the term acupuncture means a linear communication path of acupuncture points that systematically classifies all acupuncture points of the body according to functions related to the internal organs.
The World Health Organization (WHO) has established that there are 14 meridians related to the human body.

[The term "WHO Standard acupuncture site" and the significance of the "W HO Standard Code Symbol"]
In the present invention, the WHO standard acupuncture site is held in Japan in November 2006 as one of the standards in traditional medicine promoted by the World Health Organization (WHO) and the World Health Organization West Pacific Regional Office (WPRO). It is a common acupoint position in the world that was agreed upon at the expert meeting.
Further, in the present invention, the WHO standard code symbol is a symbol indicating the position of the acupuncture point with a combination of alphabets and integers based on the agreement of the WHO standard acupuncture points.

In response to a request from the WHO Western Pacific Regional Office (WPRO) to participate in the International Committee for Standardization of Acupuncture Points, the All Japan Society of Acupuncture, Japan Oriental Medicine Association, Toyo Therapy School Association, Japan The second Japan Acupuncture Committee was established in April 2004, based on the management organization of the College of Physical Therapy Teachers and the Japan Acupuncture Association.
Since its inception, the 2nd Japan Acupuncture Committee has participated in 11 meetings by Japan, China and Korea, including the International Conference on Standardization of Acupuncture Points.

Based on the agreement in November 2006, the World Health Organization (WHO) and the World Health Organization Western Pacific Regional Office (WPRO) published a book (Non-Patent Document 12) that describes the position of the global common acupoint in Japan. The translation is supervised by the Second Japan Acupuncture Committee (Non-patent Document 13).
Table 1 shows the English notation of WHO standard meridian names relative to conventional meridian names.

All the points described in Non-Patent Document 12 to Non-Patent Document 13 are marked with a combination of alphabets and integers.
Meridian names used by those skilled in the art in Japan are abbreviated using this alphabet.
What is marked with a combination of the alphabet and an integer is referred to as a WHO standard code symbol.
Tables 2 to 6 show acupuncture points described in claims 1 to 6 of the present invention.
The acupuncture points shown in Tables 2 to 6, then include Ru 7 description of items are accompanied.
(1) WHO standard code symbol.
(2) Acupuncture point names and furigana in traditional Japanese kanji notation.
(3) Anatomical acupoint position (the person skilled in the art refers to the hole position).
(4) Name of muscle tissue related to the position of the acupoint.
(5) Motor nerve name, sensory nerve name.
(6) The name of the artery with the latest maximum diameter.
(7) Disease symptom related to acupoints (the person skilled in the art will refer to it as “suji”).
Acupuncture points shown in Tables 2 to 7 showed acupuncture points related to the upper limbs.
In the present invention, in addition to the acupuncture points of the upper limbs shown in Tables 2 to 7, MV measurement values obtained from the acupoints relating to the lower limbs are analyzed.
Acupuncture points related to the lower limbs are not shown.

[Significance of the term “12th longitude”]
In the present application, the term 12 meridian means 12 meridians that have been used in the field of Oriental medicine since the WHO standard code symbol was established (renal, bladder, spleen, gastric) Liver, Biliary, Pericardial, Tricuspid, Heart, Small intestine, Lung, Large intestine).
The WHO standard code symbol is determined based on the concept of the 12th longitude.
Among the 12 meridians, there are 6 kinds of meridian in the upper limb (cardiac envelope, trifocal, heart, small intestine, lung, large intestine) and 6 kinds in the lower limb (renal, bladder, Spleen, gastric, liver, biliary).
The lengths present in the upper and lower limbs are different.

2 to 3 are examples of meridian acupuncture diagrams described in textbooks that are used as teaching materials for acupuncturist national examinations at acupuncture vocational schools recognized as various schools by the Ministry of Education, Culture, Sports, Science and Technology (Non-Patent Document 14). ).
The meridians shown in FIG. 2 are “the lunar meridian of the hand” existing in the left and right upper limbs.
The “manual lunar meridian” of the hand is usually often abbreviated as “lung meridian”.
Also in the present application, “the lunar meridian of the hand” is abbreviated as “the lung meridian”.
The meridians shown in FIG. 3 are “minoral renal meridians of the legs” present in the left and right lower limbs.
This “foot-small penile renal meridian” is usually often abbreviated as “kidney meridian”.
Also in the present application, the “small penile renal meridian” is abbreviated as “renal meridian”.

[Significance of the term “WHO Standard 12”]
In the present invention, of the 14 WHO standard code symbols shown in Table 1,
Code symbol GV (Governor Vessel)
Twelve passages excluding two passages of code symbol CV (Conception Vessel = consultation) are referred to as WHO standard 12 passages.

[Significance of the term “Gogyotsu”]
Among the acupuncture points that are reported to be 361 in the human body, there are acupuncture points represented by the classification of five-line acupuncture points.
There are five types of acupuncture points, called wells, stakes, potholes, acupuncture points, and joints. is there.

“Acupuncture” in the five-lined hole and the “acupuncture point” whose meaning is defined in paragraph [0004] have the same notation, but different meanings.

There are five types of five-line holes, one for each of 12 types of meridians of 12 meridians.
Combining 12 types of meridians with 12 meridians, there are 12 types of wells, 12 types of glory holes, 12 types of potholes, 12 types of acupuncture points, and 12 types of joint holes.
Non-Patent Document 8 shows a document that exemplifies five-line holes.
FIGS. 4 to 5 show the figures described in Non-Patent Document 8.

As described in detail in paragraphs [0080] to [0081] below, it has been traditionally considered that the five-hole has a special meaning.
This special meaning comes from the fact that the function of the acupuncture point is explained according to the five-part theory that is the philosophy of ancient China.
In the vicinity of the upper and lower limbs shown in FIG. 4, the letters “tree, fire, earth, gold, water” are attached in the vicinity.
These letters are attached according to the five-line theory and are considered to indicate the function of the acupuncture points belonging to the five-line hole.
On the other hand, according to Non-Patent Document 8, which will be described later in paragraph [0081], “the significance of the arrangement of the five-line holes is currently unknown”.
A person skilled in the art may refer to the five holes as five holes.
The upper limb and the lower limb shown in FIG. 4 are shown by dividing an area with an ellipse. This division shows a group for each type of five holes.
For example, the upper limb fingertip region classification shown in FIG. 4 is a group of “wells” shown in FIG.
Similarly, the knee region segmentation of the lower limb shown in FIG. 4 is a group of “joint holes” shown in FIG.

Of the five rows of holes, if the well of the hand is indicated by the WHO standard code symbol, it is LU11, LI01, PC09, TE01, HT09, SI01, and these wells are defined in paragraphs [0025]-[ 0026], which is the same part as the first region center acupuncture point described later.
Of the five rows of holes, if the well of the foot is indicated by the WHO standard code symbol, it is ST45, SP1, BL67, KI1, GB44, LR1, and these wells of the foot are defined in paragraphs [0025]-[ [0026] This is the same site as the first region center acupuncture point, which will be described later.

Of the five rows of holes, if the hand hole is indicated by the WHO standard code symbol, it is LU10, LI02, PC08, TE02, HT08, SI02. [0027] This is the same part as the second region center acupuncture point, which will be described later.
Of the five rows of holes, if the hole of the foot is indicated by the WHO standard code symbol, it is ST44, SP2, BL66, KI2, GB43, LR2, and these holes of the foot are, in the present application, paragraphs [0025] and [0027] This is the same site as the second region center acupuncture point, which will be described later.

Of the five rows of holes, if the hand pits are indicated by WHO standard code symbols, they are LU09, LI03, PC07, TE03, HT07, SI03, and these hand pits are defined in paragraphs [0025] and [0028] in this application. ], Which is the same as the third region central acupuncture point described later.
Of the five rows of holes, if the foot hole of the foot is indicated by the WHO standard code symbol, ST43, SP3, BL65, KI3, GB41, LR3 are used. ], The same part as the third region center acupuncture point described later.

Of the five rows of holes, if the hand acupuncture points are indicated by WHO standard code symbols, they are LU07, LI05, PC05, TE06, HT04, SI05, and these hand acupuncture points are the paragraphs [0025] and [0029] in this application. ], Which is the same part as the fourth region center acupuncture point described later.
Of the five rows of holes, if the foot acupuncture points are indicated by WHO standard code symbols, they are ST41, SP5, BL60, KI7, GB38, LR4. In the present application, these foot acupuncture points are paragraphs [0025] and [0029]. ], Which is the same site as the fourth region center acupuncture point described later.

Among the five rows of holes, if the hand joint hole is indicated by the WHO standard code symbol, it is LU05, LI11, PC03, TE10, HT03, SI08, and these hand joint holes are, in this application, paragraphs [0025] and [0030] This is the same part as the fifth region center acupuncture point, which will be described later.
Of the five rows of holes, if the joint hole of the foot is indicated by the WHO standard code symbol, it is ST36, SP9, BL40, KI6, GB33, LR8. In the present application, the joint hole of the foot is defined in paragraphs [0025] and [0030] This is the same site as the fifth region center acupuncture point, which will be described later.

[Significance of the terms “first region of the hand” to “fifth region of the hand” and “first region of the foot” to “fifth region of the foot”]
FIG. 6 schematically shows the first region of the hand to the fifth region of the hand and the first region of the foot to the fifth region of the foot.
In this application, instead of using the names of the well, the pit, the pothole, the acupuncture point, and the joint hole, The names “first region” to “fifth region” shown in FIG. 6 are used.
When this name is used, the “first region” to “fifth region” regarding the upper limb may be described as “first region of the hand” to “fifth region of the hand”.
Similarly, “first region” to “fifth region” regarding the lower limbs may be described as “first region of the foot” to “fifth region of the foot”.

Hereinafter, the significance of the first region of the hand to the fifth region of the hand and the first region of the foot to the fifth region of the foot will be described in detail.

[The significance of the terms “first region of the hand” and “first region of the foot”]
FIG. 7 shows the exact region of the first region of the hand.
In the present invention, the strict region of the first region of the hand is an in-circle range in which the value of 1/160 of the subject's height value is indicated as the first region radius (r ₁ ) centered on the well of the hand is there.
For example, in FIG. 7, the range filled with LU11 (small quotient (shosho)) existing at the tip of the first finger is the first region of the lung meridian.
Similarly, the area filled with LI01 (Shouyo) existing at the tip of the second finger is the first region of the large intestine.
Similarly, a range that is filled around PC09 (chushou) existing at the tip of the third finger is the first region of the heart envelope.
Similarly, a range that is filled around TE01 (anchor) existing at the tip of the fourth finger is the first region of the trifocal meridian.
Similarly, the area filled with HT09 (small impact) existing at the tip of the fifth finger is the first region of the heart.
There is a similar area to be painted around SI01 (Shotaku) existing at the tip of the fifth finger (not shown in FIG. 7), which is the first region of the small intestine meridian.

One first region of the hand exists for each of the six types of meridians existing in the upper limbs.

The exact area of the first region of the foot, not shown, around the Iana legs, a circle within a range indicated a value of 1 for 160 minutes in a subject height value as a first region radius (r _1).
One first region of the foot exists for each of the six types of meridians existing in the lower limbs.

[The significance of the terms “second region of the hand” and “second region of the foot”]
FIG. 8 shows the second region of the hand.
The strict region of the second region of the hand is an in-circle region in which the value of 1/107 of the subject's height value is indicated as the second region radius (r ₂ ) with the glorious hole of the hand as the center.
For example, in the three palm diagram shown in FIG. 8, the range of the palm diagram shown in the center, which is filled around the LU 10 (fish side) below the first finger, is There are two areas.
Similarly, in the three-handed palm diagram shown in FIG. 8, LI02 (bikan) existing in the middle of the second finger (second middle finger interphalangeal segment) of the palm diagram shown on the left side is filled. The area that is indicated is the second region of the lung meridian.
Similarly, in the three palm diagrams shown in FIG. 8, the range of the palm diagram shown in the center, which is filled with PC08 (Rokyu) in the palm, is the second region of the heart envelope. is there.
Similarly, in the three palm diagrams shown in FIG. 8, the range of the palm diagram shown in the center, which is filled with HT08 (Shofu) existing in the palm, is the second region of the heart. is there.

Similarly, in the three-handed palm diagram shown in FIG. 8, the range filled with TE02 (liquid gate) existing at the junction of the fourth finger and the fifth finger in the palm diagram shown on the right side Is the second region of the trifocal.
Similarly, in the three-hand palm diagram shown in FIG. 8, SI02 (maedoku) that is present in the middle of the fifth finger (fifth middle interphalangeal segment) of the palm diagram shown on the right side is filled. This range is the second area of the trifocal.

One second region of the hand exists for each of the six types of meridians existing in the upper limbs.

The exact region of the second region of the foot (not shown) is an in-circle range in which the value of 1/107 of the subject's height value is indicated as the second region radius (r ₂ ) centered on the foot hole.
One second region of the foot exists for each of the six meridians existing in the lower limbs.

[The significance of the terms “third region of the hand” and “third region of the foot”]
The strict region of the third region of the hand is an in-circle region in which the value of 1/80 of the subject's height value is indicated as the third region radius (r ₃ ) centered on the pit of the hand.
One third region of the hand exists for each of the six types of meridians existing in the upper limbs.

The exact region of the third region of the foot is an in-circle region centered on the foot hole and having a value of 1/80 of the subject's height as the third region radius (r ₃ ).
One third region of the foot exists for each of the six types of meridians existing in the lower limbs.

[The significance of the term “fourth region of the hand” and [fourth region of the foot]]
The exact region of the fourth region of the hand is an in-circle region centered on the acupuncture point of the hand and indicated by a value of 1/80 of the subject's height value as the fourth region radius (r ₄ ).
One fourth region of the hand exists for each of the six types of meridians existing in the upper limbs.

The exact region of the fourth region of the foot is an in-circle range centered on the foot hole of the foot and having a value of 1/80 of the subject's height value as the fourth region radius (r ₄ ).
One fourth region of the foot exists for each of the six types of meridians existing in the lower limbs.

[The significance of the term “fifth region of the hand” and [fifth region of the foot]]
The strict region of the fifth region of the hand is an in-circle range centered on the acupuncture point of the hand and indicated by a value of 1/80 of the subject's height value as the fifth region radius (r ₅ ).
One fifth region of the hand exists for each of the six types of meridians existing in the upper limbs.

The exact region of the fifth region of the foot is an in-circle region in which the value of 1/80 of the subject's height value is indicated as the fifth region radius (r ₅ ) with the foot hole at the center.
One fifth region of the foot exists for each of the six meridians existing in the lower limbs.

[5 areas]
In the present application, when the first area to the fifth area are collectively expressed, they are collectively referred to as “5 areas”.

[The Significance of the Terms “First Area Center Acupuncture Point” to “5th Area Center Acupuncture Point of Hand” and “First Area Center Acupuncture Point of Foot” to “5th Area Center Acupuncture Point of Foot”]
In the present application, the acupuncture point existing at the center of each region in the first region to the fifth region is defined as the central acupuncture point of each region.

The “first region center acupuncture point in the hand” will be described with reference to FIG.
The acupuncture points described with arrows attached to the palm diagram shown in FIG. 9 are “well holes”.
As described in paragraphs [0018] to [0019], a circle with the first region radius (r ₁ ) having a value that is 1/160 of the height of the subject centered around the well in the hand 1 area ". Thus, the well of the hand is the center of the first region of the hand.
Therefore, the well of the hand is referred to as “the first region center acupuncture point of the hand”.

Similarly, hereinafter, the acupuncture points existing in the center of the second region of the hand to the fifth region of the hand are referred to as “second region central acupuncture point of the hand” to “fifth region central acupuncture point of the hand”, respectively.
Similarly, the acupoint present at the center of the first region of the foot is referred to as “first region central acupuncture point of the foot”, and hereinafter, the acupuncture points present at the center of the second region of the foot to the fifth region of the foot, “Foot second region center acupuncture points” to “foot fifth region center acupuncture points”.
The area center acupuncture points in each of these areas are five-line holes.
Next, the WHO standard code for the positions of the “first region center acupuncture point” to “the fifth region center acupuncture point of the hand” and “the first region center acupuncture point of the foot” to “the fifth region center acupuncture point of the foot” It will be described in detail with symbols.

[Positions of the terms “first area center acupuncture point of hand” and “first area center acupoint of foot”
If the first region center acupuncture point of the hand is indicated by a WHO standard code symbol, it is LU11, LI01, PC09, TE01, HT09, SI01.
If the first region center acupoint of the foot is indicated by the WHO standard code symbol, it is ST45, SP1, BL67, KI1, GB44, LR1.

[Position of the term “second area center acupuncture point” and “foot second area center acupoint”]
If the second region center acupuncture point of the hand is indicated by a WHO standard code symbol, it is LU10, LI02, PC08, TE02, HT08, SI02.
If the second region center acupuncture point of the foot is indicated by the WHO standard code symbol, ST44, SP2, BL66, KI2, GB43, and LR2.

[Positions of the terms “third acupuncture center of the hand” and “third acupuncture center of the foot”
If the third region center acupuncture point of the hand is indicated by a WHO standard code symbol, it is LU09, LI03, PC07, TE03, HT07, SI03.
If the third region center acupuncture point of the foot is indicated by the WHO standard code symbol, it is ST43, SP3, BL65, KI3, GB41, LR3.

[Positions of the terms “4th region center acupuncture point of the hand” and “4th region center acupuncture point of the foot”]
If the fourth region center acupuncture point of the hand is indicated by a WHO standard code symbol, it is LU07, LI05, PC05, TE06, HT04, SI05.
If the fourth region center acupuncture point of the foot is indicated by the WHO standard code symbol, it is ST41, SP5, BL60, KI7, GB38, LR4.

[Positions of the terms “5th region center acupuncture point” and “5th region center acupuncture point of the foot”]
If the fifth region center acupuncture point of the hand is indicated by the WHO standard code symbol, it is LU05, LI11, PC03, TE10, HT03, SI08.
If the center acupoint of the fifth region of the foot is indicated by the WHO standard code symbol, it is ST36, SP9, BL40, KI6, GB33, LR8.

[The significance of the term "regional acupuncture points"]
FIG. 10 shows the second region of the hand and illustrates the “region deviation acupuncture point”.
In the present application, two “region deviation acupuncture points” are defined for each of the five regions.
An area marginal acupuncture point is two sub-measurement points defined within the area circle.
The positional relationship between these two sub measurement points and the central acupuncture point will be described.
Of these two sub-measurement points, one is determined in the fingertip direction with the central acupuncture point as the center, and the other is determined in the trunk direction with the central acupuncture point as the center.
For example, the description will be made with reference to the left palm diagram shown in FIG.
On the left of the palm diagram of FIG. 10, among the three second areas indicated by the three circles filled with circles, the second area on the left is the LU 10 (fish side) located below the first finger as a central acupuncture point This is the second region.
A point of the “second region offset acupuncture point” on the fingertip side is defined in the fingertip direction in the second region centered on the fishboard, with the LU10 (fishboard) as the center.
Furthermore, a point of a “second region marginal acupuncture point” on the trunk side is defined in the trunk direction in the second region as seen from the center of the LU 10 (fishboard).
In the present application, these two points are regarded as sub-measurement points and are defined as “second region offset acupuncture points”.
In general, those skilled in the art do not regard the “second region offset acupuncture point” defined here as an acupuncture point.

In the present application, as in the example of LU10 described above, two region marginal acupuncture points are defined in the first region to the fifth region in every 12 meridians. Yes.
In this invention, the measured value obtained by the area | region deviation acupuncture point is utilized.

[Acupuncture range]
Conventionally, it has been considered that the position of each acupuncture point, which is considered to be 361 in total, is one point on the extremely narrow skin.
For example, of the acupuncture points shown in Table 2, the LU 10 described in the seventh row is taken as an example.
The meridian indicated by the alphabet abbreviation LU means the WHO standard code symbol LU shown in Table 1. Therefore, this meridian is the lunar meridian of the hand, and LU10 corresponds to the “fishboard” of the lunar meridian of the hand.
In the present application, this acupuncture point is one of the second region central acupuncture points.
With regard to LU10 (fish's lunar meridian fish), refer to the section of “Cream area” in Table 2,
“On the first metacarpophalangeal joint, on the heel-side depression, and on the front and back of the skin”
Is specified. The point on the skin indicated by this designation is generally in the range of a radius of about 2 millimeters or a narrow range of less than that.

[MV vibration range]
Conventionally, since the area range for one acupuncture point is narrow, it has been inferred that the range of the portion that vibrates similarly in MV is also narrow.
However, when the inventor of the present application observed and examined the relationship between the MV on the skin and the acupuncture points, it was found that the MV vibration range has a wide site.
Below is a list of the discoveries of the present inventors related to the expansion of the vibration range,

(1) Especially in the MV of a subject having a disease related to cell growth control such as a tumor or a cyst, the oscillating uniformly regardless of the anatomical part of the body where the lesion such as the tumor or cyst occurs. A large amount of MV appears in a concentrated manner at the central acupuncture point in the second region in all 12 meridians.
For example, one of the second region center acupuncture points is LU10 (fishboard).

In the “conventional MV waveform measurement apparatus and technique” described later in paragraphs [0090] to [010 4 ], the position frequently used as “measurement point on the ball” is centered on LU10 (fish edge). In many cases, a value that is 1 / 107th the subject height value is provided in the in-circle range indicated as the second region radius (r ₂ ).

(2) The MV having a large vibration amount increases in proportion to the degree of lesion progression of the diseased subject.
(3) The MV having a large vibration amount appears such that the range of the vibrating portion spreads from a radius of 10 millimeters to 20 millimeters around the second region central acupuncture point.
(4) The expansion of the vibration range increases in proportion to the height value of the subject.
(5) The extent of the vibration range is narrow near the fingertips, slightly wider near the wrists and ankles, and even wider near the elbows and knees.
(6) Considering the spread of this vibration range as a circle and examining the extent of this spread by the value of radius, it is about 1/160 of the subject's height value near the finger, and near the elbow and knee joint, It is about 1/40 of the subject's height value.

When the inventor of the present application conducts the same examination with other subjects related to cell growth control, the amount of MV vibration increases in the entire area of the second region almost in proportion to the extent of the lesion progression in the lesion such as a tumor / cyst. I found out.
On the other hand, in diseases not related to cell growth control, it was found that MV having a large vibration amount was observed in other regions than the second region.

As a result of the inventor of the present application diligently examining clinical data, in the analysis of MV for the purpose of supporting diagnosis of disease, the position where the MV measurement data was obtained,

(1) WHO standard acupuncture site, and
(2) At least two secondary measurement points defined in the area indicated by the area radius value

It was found that statistically significant clinical data can be obtained by setting the three points.
In addition, in the process of examining clinical data, the present inventor has found that five regions centered on the five region central acupuncture points have extremely important significance in order to obtain statistically significant clinical data. .
The inventor of the present application has found that the conventional general concept of “acupuncture points” has an important meaning as “ main measurement point” in these five regions.
Furthermore, the inventors of the present application surprisingly found that in addition to the concept of “acupuncture points” that are “ main measurement points”, “regional acupuncture points” that are “sub-measurement points” also have important significance. .
In other words, the inventors of the present application are now a new concept that is completely different from the “ main acupuncture point” that is the “ main measurement point”, and the concept of the “regional acupuncture point” that is the “sub measurement point” It has been found that it has the same significance as the “ main measurement point” “acupuncture point”.

[The significance of the term “vibration logarithm value: (V)”]
In the present invention, when the MV measurement value obtained from the subject is compared and examined, “vibration amount logarithmic value: (V)” is defined and used.
The MV measurement values obtained from the region center acupuncture points and the region offset acupuncture points are given serial numbers with natural numbers.

In the present application, this serial number is represented by “n” in the mathematical formula used below.

MV measurements the continuous number "n" is attached will be described later in the paragraph [0045], serving list of MV measurements "amplitude score table", is input with "n" number, is stored.

[Vibration logarithm value: (V)]
The “vibration amount logarithmic value (V)” is a logarithmic notation of the vibration amount represented by the mathematical formula (2).

In the formulas (1) to (2),
f: MV amplitude value,
f _n : MV amplitude value at detector numbers shown in Table 9,
F: MV waveform integration value from the MV measurement start time to the MV measurement end time, and the amount of vibration of the MV,
V: vibration amount logarithmic value,
It is.
  In implementation, “V” is “V” _n "F" means "F" _n ”And a serial number of the detector number“ n ”shown in Table 9 is added and stored.

  F is expressed by Equation (1).

In Equation (1),
The integration interval is from the MV measurement start time to the MV measurement end time,
starting from t _0, ending with _{t E.}
The unit is seconds, and the MV measurement time.

In the embodiment of the present application, when F is obtained, an integral approximation value is obtained using spreadsheet software.
The apparatus and software for inputting the measurement values obtained from the detector to the spreadsheet software can be used by using a data logger and dedicated software supplied from the detector manufacturer.
For example, in the “SI series” and “SKG series” supplied by Keyence Corporation, MV measurement values can be stored and read out by a data storage function attached to the main body.
An example of the “SI series” is “SI-F01”. (For “SI-F01”, refer to the following URL: http://www.keyence.co.jp/henni/laser_henni/si/spec/).

The integral approximation value: F is represented by the following mathematical formula (3).

In this mathematical formula (3), for example, according to the specification of the detector used in the present invention, the sampling period is 5000 times per second.
Δτ _m = 0.2 (milliseconds)
It becomes.
Therefore, Δt = 1 may be set.

ΔA _m is the amplitude of the MV waveform.
The .DELTA.A _m values after squaring, by obtaining the square root, plus converting negative values of .DELTA.A _m values.
For example, 5000 ΔA _m values are input to the row of the spreadsheet software in accordance with the sampling period of the detector, for example, 5000 per second.
After this input, each ΔA _m value is multiplied by Δτ _m .

Further, this multiplied value is summed from the start of measurement to the end of measurement.
The summation operation is performed between the measurement start value input line and the measurement end value input line of the spreadsheet software.
An example of the summation operation is an operation of calculating between the first line to the 25000th line of the spreadsheet software.

The logarithmic value of the value generated by this calculation is obtained by Equation (2) to generate “vibration amount logarithmic value (V)”.

In the present invention, 180 MV measurement values are calculated for both the left and right limbs of the subject, and 180 “vibration amount logarithm values (V)”, ie, V _{1 to} V ₁₈₀ are obtained. .
The breakdown of these 180 is as follows.
60 pieces related to 60 central region acupuncture points and
There are 120 pieces related to 120 area marginal acupuncture points.

[Significance of the term “vibration relative value: (R)”]
In the present invention, a “vibration amount relative value (R)” is defined and used when comparatively examining MV measurement values obtained from a subject.
The “vibration amount relative value (R)” is a vibration amount logarithmic value obtained by comparing a plurality of vibration amount logarithm values (V) sets obtained from a single subject with the lowest value in the set as 0. It is the difference of (V).
The “vibration amount relative value (R)” is expressed by the following mathematical formula (4).

“R _n ”: difference between the vibration amount logarithmic value V _n obtained from one subject and the smallest value among the vibration amount logarithmic values,
“V _min ”: V _n indicating the smallest value among a set of vibration logarithm values V _n obtained from one subject,
It is.

[Significance of the term “vibration score table”]
In the present invention, a table used for displaying the vibration amount relative value (R) is defined as a “vibration amount score table”.
The amplitude score table is one piece of diagnosis support information provided to a doctor or the like by the device of the present invention.
The vibration amount score table indicates the position on the skin where the MV measurement value is detected in rows and columns.
Table 8 shows an example of a vibration amount score table displayed by inputting the vibration amount relative value (R).
Table 9 shows the position where the measurement value is detected using a conventional acupuncture point name using the vibration amount score table.

[Significance of the term “vibration score”]
In the present invention, the predetermined abbreviations and symbols described in the vibration amount score table are referred to as “vibration amount scores”.
In the specification of the present invention, the identification background color and symbol type used for the vibration amount score are “light red background”: identification background color indicating the maximum value,
Three symbols “◎”, “○”, “△”,
"": Blank indicating no input,
There are five types.
The vibration amount score is a notation obtained by converting the vibration amount relative value (R).
The vibration amount score is one piece of diagnosis support information provided to a doctor or the like by the device of the present invention.
By converting the vibration amount relative value (R) of 180 points using the vibration amount score, the visual recognition is facilitated, and the magnitude comparison between the vibration amount relative values (R) is facilitated.
Table 10 shows an example of a vibration amount score table in which vibration amount scores are input and displayed.
Next, a method of converting “vibration amount relative value (R)” into “vibration amount score” will be described.

[Significance of term “vibration amount score parameter: (A), (B), (C)”]
In the present invention, a threshold is used for the purpose of converting “vibration amount relative value (R)” into “vibration amount score”.
This threshold is defined as “vibration amount score parameter”.
In this embodiment, three vibration amount score parameters (A), (B), and (C) are used.
These (A), (B), and (C) are as follows.
Vibration amount score parameter (A): an integer value between 0 and 30 with 8 as a reference value,
Vibration amount score parameter (B): an integer value of 0 to 30 with 5 as a reference value,
Vibration amount score parameter (C): an integer value between 0 and 30 with reference value 3
And
Vibration amount score parameter (A)> Vibration amount score parameter (B)> Vibration amount score parameter (C)
It is.

When the vibration amount relative value (R)> = (A),
The vibration amount relative value (R) is converted to “◎”.

When (A)> vibration amount relative value (R)> = (B),
The vibration amount relative value (R) is converted to “◯”.

(B)> When the vibration amount relative value (R)> = (C),
The vibration amount relative value (R) is converted to “Δ”.

(C)> When vibration amount relative value (R),
The vibration amount relative value (R) is converted to “(blank indicating absence)”.

[Significance of the term “second region (R) total value: (R _II )”]
In the present application, as one piece of diagnosis support information provided to a doctor or the like, “first area (R) total value”, “second area (R) total value”, and “third area to fifth area (R) ) Total value ”is defined, and each of them is expressed as“ R _I ”,“ R _II ”, and“ R _{III to V} ”.
“R _I ”, “R _II ”, and “R _{III to V} ” are expressed by the following mathematical formulas (5) to (7).

In these mathematical formulas (5) to (7),
R _I : first region (R) total value,
R _II : Total value of the second region (R) R _{III to V} : Total value of the second region to the fifth region (R).
i: column number of vibration amount score table, natural number from 1 to 15,
It is.
A method for setting the column number “i” in the vibration amount score table will be described with reference to Table 11 .
In the vibration amount score table illustrated in Table 11 , “column number” is shown in the bottom row.
This column number is set to 1 in the leftmost column of the first area of the vibration amount score table, sequentially incremented by 1 in the right column, and set to 15 in the rightmost column of the fifth area.
The first region is a well that exists in the fingertip,
Since the fifth region is a joint hole existing around the elbow or knee, column numbers 1 to 15 are shown by replacing the position from the fingertip of the upper limb or lower limb to the elbow or knee with 1 to 15 numbers. Yes.

In Expression (6), “4 to 6” indicated by “i” indicates the second region of the vibration amount score table.
“R _II ” is obtained by summing up the vibration amount relative values (R) input to the second region of the vibration amount score table.
As a result of intensive studies on clinical data by the inventor of the present application, in particular, in the MV of a subject having a disease related to cell growth control such as a tumor or cyst, the anatomy of the body in which the lesion such as the tumor or cyst occurs It has been found that MVs having a large amount of vibration uniformly appear in a concentrated manner in the central meridian of the second region in all 12 meridian lengths regardless of the part.
Therefore, it is very significant to provide “R _II ” as one piece of diagnosis support information.

[Significance of the term “second region (R) concentration: CD”]
In the present application, “second area (R) concentration” is defined as “CD” as one piece of diagnosis support information provided to a doctor or the like.
“CD” is an abbreviation for English: Concentrated Degree.
“CD” is expressed by Equation (8) .

In Equation (8) ,
CD: second region (R) concentration,
κ: coefficient R _I : first region (R) total value: Formula (5),
R _II : second region (R) total value: Formula (6),
_RIII-V : 2nd area | region-5th area | region (R) Total value: Numerical formula (7),
It is.

For example, when the same value of vibration amount relative value (R) is input to all the squares of the vibration amount score table, if an integer “4” is used as the coefficient K, “No 2 (R) focus value” is “ 1.00 ".
When the No2 (R) focus value is “1.00”, there is no bias in the MV vibration amount detected in the first to fifth areas of the subject.
That is, at this time, the vibration amount relative value (R) is not concentrated in the second region.
As a result of intensive studies on clinical data by the inventor of the present application, in particular, in the MV of a subject having a disease related to cell growth control such as a tumor or cyst, the anatomy of the body in which the lesion such as the tumor or cyst occurs It has been found that MVs having a large amount of vibration uniformly appear in a concentrated manner in the central meridian of the second region in all 12 meridian lengths regardless of the part.
Accordingly, it is very significant to provide “second region (R) concentration degree: CD” as one piece of diagnosis support information.

[Significance of the term “MV fluctuation index value: VD”]
In the present application, “MV fluctuation index value: VD” is defined as “VD” as one piece of diagnosis support information provided to a doctor or the like.
“VD” is an abbreviation for English: Variation Degree.
“VD” is expressed by Equation (9) .

In Equation (9) ,
VD: MV fluctuation index value,
CD: second region (R) concentration,
In the present application, when VD is obtained, “1” is used as the coefficient “κ” to be assigned to CD.

As a result of the inventor of the present application diligently examining clinical data, in particular, in MV related to the disease state of cancerous disease,
(1) The magnitude of the MV vibration amount in the second region, that is, “R _II ”,
(2) It has been found that the degree to which MV appears in a concentrated manner in the second region among the five regions, that is, “CD” is positively correlated with the degree of progression of the disease.

Therefore, as shown in Equation (9), by multiplying the value of “R _II ” and the third power of “CD”, an index indicating the relationship with the progression of cancerous disease with a positive correlation is obtained. Can be generated.
The significance of providing the “MV variation index value CD” as one piece of diagnosis support information is extremely large.

[The significance of the term "diagnostic reference vibration score file"]
In the present application, the “diagnostic reference vibration amount score file” is a parameter value related to “vibration amount score parameters (A), (B), (C)” described in paragraph [0047], a determination program, and a database. A file in the computer to be stored.

[The significance of the term "medical diagnostic criteria file"]
In the present application, the “medical diagnosis reference file” is a file in a computer that stores parameter values for determining blood test data, a determination program, and a database.

[Significance of the term “鍼灸 diagnostic criteria file”]
In the present application, the term "acupuncture diagnostic criteria file", when determining the distribution of the amplitudes scores input to the amplitude scoring table in association with a disease state, and stores the cross-sectional reference information only on oriental medicine theory, the computer File.

[The significance of the term “Chinese medicine diagnosis dictionary file”]
In the present application, a “Chinese medicine diagnosis dictionary file” is provided in a database in a computer for the purpose of assisting doctors and the like in Chinese medicine diagnosis.
This "Chinese medicine diagnosis dictionary file" is illustrated using Tables 12-13 .
As described later in paragraphs [0199] to [0210], examples of the “Chinese medicine diagnosis dictionary file” and the like will be described later. And record changes in MV distribution that may be considered to be effective.

[The significance of the term "diagnosis support criteria" ]
In the present invention, “diagnosis support criteria” are used to provide biodiagnosis support information.
The diagnostic criteria include “cancerous disease diagnosis support criteria” and “Chinese medicine prescription support criteria”.
In setting the diagnosis support standard, a statistical test is performed on a population of subjects who are healthy Western medical subjects and simultaneously healthy oriental medical subjects.
Based on the average value of the tested population, a standard area is determined based on clinical experience of a doctor or the like.
Details of the “cancer disease diagnosis support standard” and “Chinese medicine prescription support standard” will be described below.

[Cancer disease diagnosis support criteria]
In the present application, two terms are defined as “cancer disease diagnosis support criteria”.
These two terms are
(1) “MV fluctuation index value: VD”;
(2) The slope of the line graph representing the time series change of “MV fluctuation index value: VD”,
It is.

In the paragraph [0157], an example of 7 healthy young people, which will be described later, is given.
(1) “MV Fluctuation Index Value: VD” in healthy young people
0.02254 ± 0.02360 (mean value ± standard deviation)
It is.

Therefore, the MV fluctuation index value: VD within this average value ± standard deviation is shown as an example of a safety value when cancerous disease is an issue.

The slope of the line graph representing the time-series change of “MV fluctuation index value: VD” given as (2) shows a positive slope when the tumor marker value increases, and a negative slope when the tumor marker value decreases. Indicates.
When this slope is zero, it can be estimated that there is no increase in the tumor marker value.
Therefore, the slope of the line graph representing the time-series change of the “MV fluctuation index value: VD” for a subject who has already undergone tumor resection for a cancerous disease is whether the disease state of the cancerous disease tends to deteriorate, Alternatively, since it indicates whether or not there is an improvement trend, it is very significant to provide it as one piece of diagnosis support information.

[Chinese medicine prescription support standards]
“Chinese medicine prescription support reference value” In setting the standard of diagnosis support information to be presented to doctors who prescribe Kampo medicine, the condition of subjects diagnosed by oriental medicine must be added to the population selection.
This is because most of the effective databases related to the efficacy of herbal medicines are traditionally created based on oriental medical criteria when doctors select herbal medicines.

[Significance of the term “tumor”]
In the present invention, tumors are equivalent to the following description indicated by "Kojien" fourth edition, Iwanami Shoten, November 15 daily Fourth Edition, 1991. That is,
“ A lesion in which somatic cells become abnormal and excessively proliferate. In many cases, a localized nodule is formed as a tumor or swelling in an organ or tissue. It is also divided into benign (adenoma, lipoma, fibroma, osteoma, etc.) and malignant (sarcoma, carcinoma, etc.) according to the nature of the growth .

[Significance of the term “cyst”]
In the present invention, the cyst conforms to the following contents indicated by the 18th edition EPWING edition of Nanzan-do Medical University Dictionary. That is,
The word origin of English cyst (Germany; Zyste, French; kyste) comes from the Greek word kustis. It is a sac-like mass surrounded by walls with liquid content. It is divided into a true cyst with an epithelial coating on the inner surface and a pseudo cyst with no epithelial coating. Cysts are classified as follows:
1) Congenital (developmental) cyst: It is derived from abnormal developmental processes (branchiogenic c. Etc.).
2) Inflammatory cyst inflammatory c. : Secondary to inflammatory changes (such as root cysts * radicular c.).
3) Degenerative cyst degenerative c. : Secondary to tissue necrosis (such as cystic changes in goiter).
4) Retention cyst * retention c. : Expansion of the gland duct due to the storage of secretory contents (eg Nabot egg * Nabothian follicle in the uterus).
5) Implantation cyst implantation c. : The epithelium is transplanted into connective tissue (such as epidermoid tumors).
6) parasitic cyst parasitic c. (For example, hydatidc.).
7) proliferative cyst hyperplastic c. (Such as a mammary cyst).
8) Neoplastic cyst neoplastic c. (Such as ovarian cystadenoma).
It is.

[The term "poly-flops or, polyp" significance of "
In the present invention, the poly-flops also, polyps and is, pursuant to the next of the content indicated by the "Kojien" fourth edition, Iwanami Shoten November 15, Nikkan fourth edition in 1991. That is,
English name: Polyp. An oval mass protruding from the surface of the skin, mucous membrane, etc. and having a stem. Some are caused by chronic inflammation, others are benign neoplastic, and are easily formed in the nasal cavity (nasal _fins ), gastrointestinal tract, and bladder .
And the contents of
The following contents are shown in the 18th edition EPWING edition of the “Nanjing Medical Dictionary”.
<Synonyms> Adenoma, protruded lesion
A polyp is a collective term for localized bulging of a mucosal macroscopically pedicle, and is a name for a gross form that is irrelevant to its tissue constituents. There are gastric polyp, colon polyp, nasal polyp, cervical polyp, urethral polyp, etc. The term polyp is also used for localized raised lesions, in which case it is expressed as sessile polyp or pedunculated polyp.

[Significance of the term “CEA (carcinoembryonic antigen)”]
In the present invention, CEA means carcinoembryonic antigen (carcinoembryonicantigen).
CEA is localized in glycocalyx in close contact with the luminal cancer cell membrane in CEA-producing colorectal cancer cells according to the Medical Dictionary (Nanyamado, 18th edition, EPWING edition). May be positive not only for malignant tumors such as pancreatic cancer, lung cancer, liver cancer, breast cancer and neuroblastoma, but also for non-neoplastic lesions such as cirrhosis, chronic hepatitis and renal dialysis. It is present in small amounts in normal tissues of adults such as pancreas, lungs, liver, mammary gland, prostate, and intestinal tract as well as colon cancer tissues, and generally has a high value in adenocarcinoma. Although sex is faint, it is used for diagnosis of tumor and determination of its change.

[Significance of the term “CA19-9”]
In the present invention, CA19-9 is a sugar chain antigen recognized by the monoclonal antibody NS19-9 against cultured colon cancer cells, and indicates a sugar chain antigen also called sialyl Lewis A.
The normal serum levels of normal humans are 95% for 20 U / ml or less and 98% for 37 U / ml or less. For example, “CA125, CEA, CA19-9 content in cervical mucus” Yoshihiko Nanbu et al., Kyoto University School of Medicine, Department of Gynecology and Obstetrics, Journal of Japanese Society of Obstetrics and Gynecology Acta Obst Gynaec Jpn Vol.40, No.10, pp. According to 1519-1524, 1988 (October 1988), the value of CA19-9 in cervical mucus of women without gynecological abnormalities is 3470 ± 500 U / ml (mean value ± standard error) menstruation There was no difference due to the cycle, and the CA19-9 value was significantly higher in the cases of cervical polyps and vaginitis than in healthy women, and the cases of cervical polyps and vaginitis It was shown that the CA19-9 value was reduced by administering the female hormone preparation estriol suppository to the treatment of the above.

[Significance of the term “skin”]
In the present invention, the skin includes the dermis and epidermis constituting the skin and the stratum corneum of the epidermis.

[Significance of the term “MV waveform”]
In the present invention, the MV waveform is a time-dependent change in a physical quantity at a certain point of the skin and / or subcutaneous tissue, or / A graph showing spatial changes. It includes a waveform shown by the primary graph, a graph called a velocity waveform by a person skilled in the art obtained by linear differentiation of the waveform of the primary graph, and an acceleration waveform obtained by secondary differentiation of the velocity waveform.

[Significance of the term “high amplitude part”]
In the present invention, the high-amplitude region means a region having a relatively large value when comparing the height difference values of the stratum corneum surface caused by the three-dimensional movement of the epidermis in at least two body regions. means.

[Significance of the term “diagnosis”]
The present invention includes diagnosis of general medical diseases by a doctor and diagnosis of diseases based on Oriental medicine theory.

[Significance of the term “subject”]
In this invention, it is a human who receives the measurement of MV, and it does not matter whether there is a subjective symptom due to a disease and / or whether there is a potential disease.
In the invention of the present application, the patient who came to the hospital with a chief complaint at Seijo Toyo Sanin Toyo Sanin where the inventor is engaged, his family, and his / her family, was visited for the purpose of health checkup. Means a healthy person.

[The significance of the term "at rest awakening"]
In the present invention, resting and awakening refers to a state in which a human is awake in a resting state without exercise, except for a time period immediately after the human exercise.
For example, the human body condition is included in which the human body weight is deposited on a body support device that supports the body, such as a bed and a chair, and does not involve a large body motion.

[The significance of the term “herbal medicine”]
In the present invention, herbal medicine simply means a single herbal medicine that is not mixed.

[Significance of the term “MV score corresponding to herbal medicine”]
In the present invention, “MV-corresponding score value in herbal medicine alone” is data indicating the efficacy of herbal medicine.
When comparing the MV vibration amount relative value (R) of the subject before taking herbal medicine and the MV vibration amount relative value (R) after taking the drug, when the symptoms are improved, the former (R) and the latter ( The difference from R) is defined as “MV score corresponding to herbal medicine”.

[Terms used for problems in Non-Patent Document 2]
[Significance of the term “judgment mechanism in human brain”]
In the present application, the term “determination mechanism in the human brain” is used as a term used in the problem of Non-Patent Document 2.
The meaning of this phrase is that a person actually touches a specific object or abstract concept, understands what it is, and recalls previously learned items related to the object from memory. This is a mechanism for estimating and judging pass / fail.

[The significance of the term "information held by an unknown object located remotely from the body"]
In the present application, the term “information held by an unknown object at a position remote from the body” is used as a term used in the problem of Non-Patent Document 2.
The meaning of this phrase is a remotely located subject that is not touched at all by the subject's body and cannot give any information about the subject or obtain any information, Information that is completely unknown to the subject that such object has.

[Terminology of measuring equipment]
[Significance of the term “Class 1 Laser”]
In the present invention, a class 1 laser means a laser that is at a level that is safe for the eyes, regardless of what optical system (lens or telescope) is used for focusing. No special measures are required other than a label indicating that it is Class 1. It is defined in JIS (Japanese Industrial Standard) C6802.
[Overview of laser class and class-specific risk assessment]
Class 1: inherently safe by design.
Class 1M: Low output (wavelength of 302.5 to 4000 nm). It is safe under certain conditions including in-beam observation. Observing with optical means in the beam can be dangerous.
Class 2: Low output with visible light (wavelength of 400 to 700 nm). The eyes are protected by the aversion reaction of the eyes, including the direct beam observation state.
Class 2M: Low output with visible light (wavelength of 400 to 700 nm). The eyes are protected by normal eye disgust. Observing with optical means in the beam can be dangerous.
Class 3M: 5 times or less (400 to 700 nm wavelength) of class 2 for visible light, and 5 times or less of class 1 (wavelength of 302.5 nm or more) for non-visible light. Direct observation in the beam may be dangerous.
Class 3B: Output of 0.5 W or less. Direct in-beam observation is dangerous.
However, observing pulsed laser radiation that is not focused by diffuse reflection is not dangerous and can be observed safely under certain conditions.
Class 4: High output. May cause dangerous diffuse reflection. These can cause skin damage and can be a fire hazard.

[Overview of Meridians, Acupuncture Points, and Five-Year Holes in Traditional Oriental Medicine]
Traditionally, in Oriental medicine theory, acupuncture points (acupuncture points) scattered on the body skin are connected in a line to draw a path on the skin, and this is called the meridian that associates the medical function with a specific organ. Medical route is used.
This meridian includes (1) a meridian called the meridian 12 meridian,
(2) A meridian passing through the midline of the trunk and the trunk line (for example, a line passing through the center of the trunk connecting the eyebrows, nose, mouth, navel, anus, spine) called the appointment pulse,
(3) A meridian called “miracle” is used.
This 12 meridian is a meridian defined in the WHO standard code symbol.
It is known that there are twelve types of meridians in this meridian 12 meridian.
These twelve types of meridians each have acupuncture points called wells, sakae holes, potholes, acupuncture points, and joint holes, which are called five-line holes or five-pointed holes.
For example, in Non-Patent Document 8, “Even if they are the same meridians, they have the feature that other visceral moths are flowing in the five-line hole. It can be applied to the treatment. "
Using FIG. 4 shown in Non-Patent Document 8, the “features of the position of the five holes” will be exemplified.

According to this non-patent document 8,
“If the five-line theory is correct, this arrangement should have a built-in mechanism for finely harmonizing the movement of the person from the tip of the finger to the elbow. There is also a principle that properly uses the mutual influence between the five limbs in the lower limbs, which is considered to be a very important acupuncture point in analyzing human movements. "
And describes the advantages of the five-way hole.

[Problems of Meridians, Acupuncture Points, and Five-Year Holes in Conventional Clinical Medicine]
The problems of the meridians, acupoints, and the five-pointed hole in clinical medicine from the past,
“The significance of the arrangement of the five hole positions as shown in FIG. 4 is currently unknown.”
It is represented by the statement.

In other words, since the significance of the position and arrangement of the five-membered hole is unknown at this time, the technology for grasping the precursors of diseases related to cell growth control such as tumors and cysts from physical measurements obtained from this five-membered hole There was no.

[Outline of Patent Document 1 (most recent prior art) using meridian and acupuncture biological reactions in clinical practice]
2. Description of the Related Art Conventionally, non-invasive devices for evaluating the functional state of a living body such as autonomic nerve function and organ function by measuring meridians and acupoints in the Oriental medicine theory have been developed. For example, there is a biological reaction waveform information analysis method and apparatus and diagnostic apparatus disclosed in Patent Document 1 (the latest prior art). This device is a kind of measuring device known as a skin impedance method using the electrical reaction of acupoints.
However, Patent Document 1 is a technique using “skin impedance”, not a technique using “microvibration (MV)”, and has a technical basis completely different from that of the present invention.

[Apparatus configuration of Patent Document 1 (nearest prior art)]
FIG. 11 shows an outline of the device configuration of Patent Document 1 (the latest prior art).
The entire device is
An apparatus (1 in FIG. 11) for detecting an electrical waveform obtained from a living body;
A diagnostic apparatus (2 in FIG. 11) for performing a medical diagnosis using the obtained electrical waveform;
It consists of a part with the apparatus (3 of FIG. 11) which displays a diagnostic result.

[Mode of using the device of Patent Document 1 (the latest prior art)]
The apparatus outline of patent document 1 (nearest prior art) is shown using FIG.
In patent document 1 (nearest prior art), acupuncture points called wells defined at the tips of fingers and toes are used as measurement points among WHO standard acupuncture sites.
A detector of the measuring device is attached to this measuring point.
The ground wire of the measuring device is guided and pasted to a site remote from the measuring point (in the example of FIG. 11, the wrist as an example).
Thereafter, a weak pulse current is applied to the electrode, and the output is input to the body reaction waveform measuring device (1 in FIG. 11), and as a result, the reaction current output is obtained from the body.
By comparing and examining the waveform of the obtained reaction power output, the health condition and disease state of the subject body are diagnosed.

[First advantage of Patent Document 1 (nearest prior art)]
The first advantage of Patent Document 1 (the latest prior art) is
A new parameter is defined by adding / subtracting values to each other without simply using the values of the electrical waveform obtained from the living body.
As a result, the measurement values that have been unstable due to individual differences are regarded as stable data.

[Second Advantage of Patent Document 1 (Recent Prior Art)]
The second advantage of Patent Document 1 (the latest prior art) is
In a diagnostic apparatus that performs medical diagnosis using the obtained electrical waveform, several types of dictionary file areas are provided in the computer for use as diagnostic criteria, and dictionary file data created in advance is recorded in these areas for diagnosis. The database is used as a reference and is used for comparative diagnosis.
Examples of this are shown in FIG.

[Problems of Patent Document 1 (Recent Prior Art)]
As a result of studying Patent Document 1 (the latest prior art), the inventor of the present application has determined the measurement method indicated by Patent Document 1 (the latest prior art), that is, the tips of the fingers and toes as shown in FIG. In the method of using the measured wells as measurement points, measuring the skin impedance at those limited measurement points, and comparing the obtained measurement values, the constitution of the subject is controlled for cell growth such as tumors and cysts. It was found that this is insufficient for the purpose of finding out whether or not it is shifting to a constitution that is likely to cause diseases related to.
Furthermore, the inventor of the present application compares the MV measurement data with the disease state of the subject, and thereby obtains the MV measurement values obtained simultaneously from all the acupuncture points shown in Tables 2 to 7 as well as the wells. By comparing, it was found that the precursors of diseases related to cell growth control such as tumors and cysts can be clearly understood.
However, Patent Document 1 is a technique using “skin impedance”, not a technique using “microvibration (MV)”, and has a technical basis completely different from that of the present invention.

[Physiological significance of MV as background technology]
Although not recognized by the naked eye, there have been numerous research presentations since Rohracher's report on the basics and clinical aspects of microvibration (MV) of physiologically existing body surfaces.
For example, in the report shown in Non-Patent Document 9, an attempt to apply MV as one of the autonomic nervous function tests has been developed.
Conventionally, a clear and unified view has not always been obtained about the mechanism of MV generation.
As described in paragraph [0003] about the physiological significance of MV, several medical features have been revealed by researchers.

[Basic principle of MV waveform measurement]
The conventional principle of MV waveform measurement is based on the principle of detecting tremor as acceleration using a piezoelectric element or the like as a micro vibration detection sensor. For example, Non-Patent Document 3 shows that the MV measurement method at the initial stage of research in 1958 was the same as the current method.

[Conventional MV Waveform Measuring Apparatus]
A conventional method for measuring an MV waveform is shown in FIG. The device shown here
Vibration detection device (1 in FIG. 12),
Vibration signal amplifier (2 in FIG. 12),
Vibration signal recording device (3 in FIG. 12),
Vibration waveform display device (4 in FIG. 12),
It is comprised including.
The vibration detection device (1 in FIG. 12) is an MV detection sensor. For example, a minute vibration of the skin is detected as a displacement amount using a piezoelectric acceleration pickup.
The detected signal is output to the vibration signal amplifying device (2 in FIG. 12).
The waveform of the signal amplified by the vibration signal amplifying device (2 in FIG. 12) is recorded in the vibration signal recording device (3 in FIG. 12).
The signal waveform is displayed on the image by the vibration waveform display device (4 in FIG. 12).
For example, Non-Patent Document 4 shows a method of measuring using a Nihon Kohden MV pickup MT-3T (3 g) or a Rion vibration acceleration pickup PV-20A (1.2 g) as a vibration detection device. .

[Conventional MV frequency analyzer]
In the case where it is necessary to obtain the MV vibration frequency in addition to the method of measuring the MV waveform, the apparatus shown in FIG. 12 has been conventionally used. That is,
(5 in FIG. 12) vibration frequency analyzer,
(6 in FIG. 12) Vibration frequency analysis value averaging device,
(7 in FIG. 12) vibration frequency analysis result display device,
Is a vibration frequency analysis device configured to include
The signal amplified by this vibration signal amplifying device (2 in FIG. 12),
Or
The signal recorded in the vibration signal recording device (3 in FIG. 12)
Output to vibration frequency analyzer (5 in Fig. 12)
The signal waveform is displayed on the image by the vibration waveform display device (4 in FIG. 12).
If you need more,
The signal waveform is analyzed by the vibration frequency analyzer (5 in FIG. 12), and the amplitude intensity is obtained for each frequency.
If you need it,
The analysis values are averaged by the vibration frequency analysis value averaging device (6 in FIG. 12).
It is also possible, and finally
It is also possible to obtain a logarithmic value of the frequency constituting the MV by the vibration frequency analysis result display device (7 in FIG. 12) and display it in decibels for each frequency component.
For example, in Non-Patent Document 5, using the frequency analysis result obtained in this way, the curve drawn by the spectrum envelope is integrated for each frequency, and the obtained integrated values are compared with each other to compare the frequency intensity. How to do is shown.

[Outline of medical technology using conventional MV waveform measurement results]
Next, a conventional medical technique using the MV waveform measurement result will be described.

[Applied research in pediatrics]
Non-Patent Document 6 to Non-Patent Document 7 compare MV obtained by measuring the top of the head as a medical application research of MV, and fingertip volume pulse wave. Is described as a technique for monitoring the occurrence of orthostatic dysregulation in pediatrics by recording the above correlation as an index for estimating the blood flow rate of the heart. The fingertip volume pulse wave is one of pulse waves obtained by measuring the pulse pressure under the fingertip of a hand using a small pulse pressure meter. Orthostatic dysregulation in pediatrics refers to dizziness that occurs mainly in children.

[Applied research in cardiology]
For example, as shown in FIG. 13 and FIG. 14, Non-Patent Document 5 reports an example of a clear difference in MV waveforms when a healthy adult and a heart disease patient are subjects.

[Advantages of applied technology in cardiology]
FIGS. 13 to 14 show examples of clear changes in MV waveforms of healthy adults and heart disease subjects shown in Non-Patent Document 5, and a diagnosis technique that uses MV waveform measurement results that have been clarified in the past. The advantages will be described.
FIG. 13 shows the relationship between MV, electrocardiogram, and respiratory curve in the thumb ball of the left hand of a healthy adult.
In healthy adults, the MV of the thumb ball and the electrocardiogram coincide with each other and do not coincide with the respiration curve.

FIG. 14 shows the relationship between the MV of the parietal limb, the MV of the thumbball, the MV of the eyelid, and the electrocardiogram in a subject with a heart disease in which electrical signals that stimulate the atrial myocardium are blocked, ie, complete atrial block disease. Show.
In subjects with complete atrial block disease, the MVs of the parietal and thumb bulbs coincide with the electrocardiogram.

Therefore, since the deficiency of the electrical signal shown on the electrocardiogram is reflected in the MV of the parietal and thumbballs and appears as a deficit as well, the above-mentioned disease is obtained by monitoring the MV of the parietal and thumbballs. It has been shown that electrical signal deficits in a subject's atrium can be monitored non-invasively.

[Outline of Patent Document 2 (Recent Prior Art) Using MV Waveform Measurement Results]
In Patent Document 2 (the latest prior art),
Depending on the judgment mechanism in the human brain, it is impossible to judge the quality at all. The amplitude value of its own MV waveform is changed to a high value.
Therefore, by using such a biological reaction that changes the amplitude value of the MV waveform to a high value, it is possible to determine the quality of information that is located at a position remote from the body and that is completely unknown. It is said that.

[Advantages of Patent Document 2 (Recent Prior Art)]
As a result of the inventor of the present application performing repeated follow-up tests by the schematic diagram and method of the apparatus shown in Patent Document 2 (nearest prior art), and attempting to obtain the results shown in each claim by this technology, Any data obtained could not be statistically significant data sufficient to prove the results shown in Patent Document 2 (the latest prior art).
Therefore, as an advantage in Patent Document 2 (the latest prior art), it was considered that “negative data” deserves new consideration .

[Problems of Patent Document 2 (Recent Prior Art)]
[First problem of Patent Document 2 (nearest prior art)]
As a result of the inventor of the present application performing repeated follow-up tests by the schematic diagram and method of the apparatus shown in Patent Document 2 (nearest prior art), and attempting to obtain the results shown in each claim by this technology, Any data obtained could not be statistically significant data sufficient to prove the results shown in Patent Document 2 (the latest prior art).
Therefore, the first problem of Patent Document 2 (nearest prior art) is to reexamine the factors that can change the MV in the body at rest awakening,
It was there.
That is, the change in MV does not indicate a change due to factors outside the subject's body as shown in Patent Document 2 (the latest prior art), but rather a medical problem inside the body that generates MV. It was a problem that there was a possibility of influence.

[Second problem of Patent Document 2 (nearest prior art)]
The second problem of Patent Document 2 (the latest prior art) is
It is necessary to reexamine the body part that shows MV changes in the body at rest awakening,
It was there. In other words, in the example of Patent Document 2 (the latest prior art), the MV of the thumb ball is intensively measured, but when obtaining biometric information from the MV measurement value, it is obtained from the thumb ball. It was a question whether the data observed with emphasis only on the measured MV values contained sufficient biological information.
Furthermore, according to Patent Document 2 (the latest prior art), if any external factor affects the subject's body, the MV may be the thumb ball or any other part of the body. In the same way, the inventor of the present invention shows a significant change in the amplitude value. As a result of measuring the MV of various subjects by the inventor of the present application, the MV is uniformly measured at every measurement point on the body. The result is that it does not indicate a change in value.

15-16, the problem clarified by the conventional MV basic research, the problem of the conventional MV application technology in medical care, and the problem of patent document 2 (nearest prior art) are shown. An example is shown.
The two bar graphs shown in FIGS. 15 to 16 are examples of the MV analysis that helped clarify the problem.
These graphs measure the MV of a certain subject and record the amplitude value for each body position.
The position of the body from which the amplitude values related to the two bar graphs shown in FIGS. 15 to 16 are obtained will be described with reference to FIG.
Below FIG. 17, the figure of the upper limb already shown in FIG. 4 (“feature of the position of the five holes”) was extended and used.
The upper bar graph of FIG. 17 is the same as the bar graph of FIG.
Five arrows appear from the figure of the upper limb of FIG. 17 to show the five labels shown below the bar graph.
That is, the MV vibration amount obtained from the acupuncture points existing in the original ellipse of the arrow is represented as bar graph data at the tip of the arrow.

Below the two bar graphs shown in FIGS. 15 to 16, there are five labels which are described as “first region” to “second region”.
The areas indicated by the five labels are areas set in the upper limb and the lower limb in the present application.
Immediately below these five labels, “R _I ”, “R _II ”, and “R _{III to V} ” are described.
The “R _I ”, “R _II ”, and “R _{III to V} ” are the regions obtained by the equations (5), (6), and (7) described in the paragraphs [0048] to [0050]. Each vibration amount relative value: the sum of (R).

FIG. 15 shows the MV amplitude distribution pattern of February 13, 2005 when this subject visited the hospital with the initial symptoms of the common cold.
16 shows this when the same subjects were re-admitted on February 24, after 11 days, the time when the heat generation was confirmed that also converge symptoms of the common cold, the MV vibration momentum relative value distribution pattern.

These two different time-series change in physical symptoms related to vibration momentum relative value to compare with each other to become apparent,
(1) As shown in FIG. 15, when the early symptoms of the common cold is a physical condition in a subject is the peak of the vibration momentum relative values are concentrated disproportionately to the fourth region,
(2) As shown in FIG. 16, (1) after 11 days, when the heat generation was also converged cold symptoms may be relatively small peak of vibration momentum relative value appears in the first region and the third region,
(3) At the same time, the peak of the fourth region that appeared in the initial symptoms is further reduced,
It is.

When the inventor of the present application analyzes and examines the MV measurement values obtained from subjects who have other diseases such as the common cold,
(1) The anatomical position where MV appears strongly on the skin has a correlation with medical problems inside the body,
(2) The amplitude intensity of MV shows a change with a positive correlation with the magnitude of the degree of medical problem,
I found.

[Relationship between Invention of the Present Application and Patent Document 2 (Recent Prior Art)]
In Patent Document 2 (the latest prior art), when an unknown object has information obtained at a position remote from the body that cannot be determined at all by a determination mechanism in the brain of the subject, When it is beneficial to the subject, the pass / fail judgment operation of the unknown object is associated with the change in the MV amplitude value under the assumption that the amplitude value of the subject's MV changes to a high value.
Therefore, Patent Document 2 (nearest prior art) is as in the present invention,
A biological reaction waveform information analyzing apparatus that measures a biological microvibration waveform generated by a living body and obtains the measured biological microvibration waveform.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, the n th measurement site represented by a natural number within the range of 1 to n _E
The integral obtained by integrating the amplitude f _n (t) at the time t in the time range from the time t ₀ to the time t _E with respect to the measured biological microvibration waveform, as shown in the equation (1).
Calculate the amount of vibration (F _n ),



Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2) ,



While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2) ,
Based on Equation (4),
The vibration amount phase which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min )
Calculate the pair value (R _n )



Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above ,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;
A biological microvibration analysis apparatus comprising:

as well as,
A biodiagnosis support device for measuring a waveform of a biological microvibration generated by a living body and based on biological response waveform information obtained from the measured waveform of the biological microvibration.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, the n th measurement site represented by a natural number within the range of 1 to n _E
The integral obtained by integrating the amplitude f _n (t) at the time t in the time range from the time t ₀ to the time t _E with respect to the measured biological microvibration waveform, as shown in the equation (1).
Calculate the amount of vibration (F _n ),



Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2) ,



While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2) ,
Based on Equation (4),
The vibration amount phase which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min )
Calculate the pair value (R _n )



Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above ,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;

The vibration amount relative value (R _n ) for each measurement site represented as a list obtained by the second means is expressed as follows :
Based on Equations (5) to (7),
A first region total vibration amount relative value (R _I ) as a total value of vibration amount relative values (R _n ) belonging to the first region ;
Second region total vibration amount relative value (R _II ) as a total value of vibration amount relative values (R _n ) belonging to the second region ,
Total after the third region as the total value of the vibration amount relative values (R _n ) belonging to the third region to the fifth region
Relative vibration value (R _{III ~ V} )
A third means for calculating



First region total vibration amount relative value (R _I ) and second region total vibration amount calculated by the third means
Relative value (R _II ) and total vibration amount relative value (R _{III ~ V} ) from the third region onward ,
Based on Equation (8), a second region amplitude concentration index (CD) that is an index of the degree of concentration of biological microvibration on the second region is calculated and displayed.




And / or

Fourth means for calculating and displaying a biological microvibration fluctuation index (VD), which is an index of the magnitude of fluctuation of the biological microvibration in the entire region, based on Equation (9)


It is completely different from the biodiagnosis support apparatus characterized by comprising

Japanese Patent No. 3562798 (Japanese Patent Laid-Open No. 2002-253521) Analysis method and apparatus for biological reaction waveform information and diagnostic apparatus Japanese Patent Application Laid-Open No. 07-059755

In the technical field to which the invention according to the present application belongs, reference documents (non-patent documents) to be referred to in order to understand the technical level of knowledge that a person skilled in the art should have on the date of appearance of the present application are listed below.
"Research results of evaluation of Chinese medicine by skin impedance method" Tamiko Okura et al. "Wakan Journal of Pharmaceutical Sciences" Vol. 15, 264, 1998 “Synchronization of Qigong by measuring meridians” “Human Science” (Vol. 2 (1), 19-29, 1993) “Generation mechanism of komakai furu”, Hisanobu Kanno and Kazutoyo Inanaga, “Brain and Nerve”, Vol. 10, No. 11, 1958, 23-34 “Examination of autonomic nervous function in subjects with vibration disorder by Mirovibratio on the thumb ball” Noriaki Harada and Koichi Kondo, “Autonomic nerve” 23: 1986, p490-p495 “Microvibration, physiological significance” written by Toshiyuki Ozaki, “Clinical EEG”, Vol. 14, No. 1, 1972, 1-10 `` Application of microvibration on body surfacein diagnosis of ort hostatic dysregulation '' Igarashi, K. Tohoku J. exp. Med., 102, p207-p208, 1970 `` Microvibration on the Scalp as a DiagnosticAid in Orthostatic Dysregulation '' Igarashi, K. Tohoku J. exp. Med., In press, 1971 "Diagnosis and Acupuncture with Meridian Test" (Medical and Dental Publishing, March 10, 2006, p. 26) Yoshito Mukono (Professor, Graduate School of Physical Education, Fukuoka University, Lecturer 2, Fukuoka University Hospital, Sports Medicine, Medicine Dr.) “Diagnosis and treatment of autonomic dystonia-from a psychiatric medical standpoint” Haruo Tetsuo, Kaoru Kuroki, Kenichi Matsumoto, Tomonobu Kawano, Takashi Mori, Ichiro Hotta, etc. 2398, 43-48, 1970 "Experience of introducing tumor markers in risk selection -CEA AFP-" Mitsunobu Sasaki et al., Journal of the Japan Insurance Medical Association, Vol. 87, 1989 "Yakucho" by Yoshimasuto Todo, 1771 "WHO STANDARD ACUPUNCTURE POINT LOCATIONS INTHE WESTERN PACIFIC REGION" 1st Edition (2008/6/25), ISBN-10: 9290613831 “WHO / WPRO Standard Acupuncture Site” WHO West Pacific Regional Secretariat, Supervised by the Second Japan Acupuncture Committee, Medieval Japan, 2009 http://www.idonohippon.com/book/shinkyu/1117-3. html "Meridian Acupuncture Diagram", supervised by Mitsuyoshi Kobayashi, written by Jin Nakayama, Hoei Planning, 1995 “Experience of introducing tumor markers in risk selection” Mitsunobu Sasaki et al./Yasuda Life Mutual Insurance Company, Journal of Japan Insurance Medical Association, Vol.87, 1989, Recorded in National Institute of Informatics Paper Information Navigator [Signy]

[Problems to be solved by the invention]
The problem to be solved by the present invention is to provide a biodiagnosis support apparatus that contributes to the diagnosis of a disease based on the MV information detected from the five holes and the surrounding specific area newly found by the present inventor.
Here, the MV information includes a waveform, vibration amount, amplitude, and frequency related to MV as a wave.
Here, the disease includes diseases related to cell growth control (such as tumors and cysts) and precursor states of these diseases.
In the prior art, trying to measure MV at the meridians and / or acupoints is insane and uncommon for those skilled in the art.
In addition, it was completely unexpected for those skilled in the art to measure MV in the five-line hole and / or the peripheral region of the five-line hole, which is a subordinate concept of meridians and acupoints.
The position / arrangement of the five-row hole has been handed down since ancient times, and it is unique among the persons skilled in the field of oriental medicine, particularly those skilled in the field of oriental medical treatment such as acupuncture and sputum. It goes without saying that there is no need to wait.
However, in the conventional technology, the position / arrangement of the five holes is a part where the treatment action such as acupuncture and acupuncture is “INPUT”, and a part for obtaining “OUTPUT” from which information is obtained. As, it has hardly been recognized.
Barely, only in Patent Document 1, the skin impedance is measured in the wells included in the five holes.
However, the embodiment in Patent Document 1 aims to detect the balance between sympathetic nerves and parasympathetic nerves, and is related to diseases associated with cell growth control (such as tumors and cysts) and precursors of these diseases. It is not intended to diagnose the condition.
Patent Document 2 is not intended to diagnose diseases associated with cell growth control (such as tumors and cysts) and the precursor states of these diseases.
In other words, in the conventional technology, a five-hole is recognized as an “OUTPUT” site for obtaining information, and a disease related to cell proliferation control (tumor, cyst, etc.) based on a physical measurement value obtained from the five-hole. ), As well as technologies that contribute to the diagnosis of the precursor state of these diseases.

[Solution issues in conventional MV basic research]
According to conventional MV basic research, it is known that skeletal muscle tonicity MV may appear overlapping with MV waveform caused by heartbeat when subject is in awake resting state (Non-patent Document 5). .
However, there is a phenomenon in which the skeletal muscle tone MV does not appear to overlap with the MV waveform caused by the heartbeat when the subject is in the awake resting state, and the reason for the appearance of these two phenomena remains unknown. there were.
On the other hand, in the first place, it remains unclear for what reason skeletal muscle tone MV is caused.
In the first place, the physiological significance of skeletal muscle tonicity MV remained unknown.
That is, the inventor of the present application has promoted scrutiny of conventional MV basic research. As a result, (1) skeletal muscle tonicity MV appears alone and MV waveform caused by heartbeat appears superimposed. It is unclear why, and (2) the reason why skeletal muscle tonic MV appears is unknown, and (3) the physiological significance of skeletal muscle tonic MV is also unknown. I came to realize that this is a solution issue in MV basic research.

[Positioning of MV in conventional MV basic research (significance)]
Non-Patent Document 5 discloses an MV waveform (eyelid, parietal, thumb ball) and electrocardiogram waveform of a subject with complete atrial block disease as shown in FIG. 14 in the present application.
And in nonpatent literature 5, as shown in FIG. 14 in this application, based on the waveform by electrocardiogram measurement based on the MV waveform measured by the thumb ball, the eyelid, the frontal region, the parietal region, etc. of the measurement subject's hand It is disclosed that a heart disease is diagnosed as well.

[Position of MV found by the present inventor (significance)]
The inventor of the present application reads from FIG. 14 in the present application as knowledge that the original authors did not recognize as a result of scrutinizing the MV and electrocardiogram waveforms (FIG. 14 in the present application) disclosed in Non-Patent Document 5. So that it is possible

(1) While the MV and ECG waveforms measured on the parietal and thumbballs match,

(2) The MV waveform of the eyelid is superimposed on the waveform of the electrocardiogram and another waveform of unknown origin other than the waveform of the electrocardiogram.

I found out.

That is, in contrast to the MV waveform measured at the parietal and thumb ball, which is almost equivalent to the ECG waveform, the MV waveform of the eyelid is obtained from the ECG, which is different from the ECG waveform. I came up with the experimental hypothesis that it contains other medical information (disease information) different from that.

In other words, the MV waveform of the eyelid is a combination of multiple waveforms, and other medical information different from that obtained from the electrocardiogram by canceling the waveform of the electrocardiogram and separating the waveform I came up with an experimental hypothesis that (disease information) can be extracted.

Therefore, the inventor of the present application tried to determine a disease state other than the heart disease by canceling the waveform of the electrocardiogram from the MV waveform of the eyelid and separating the remaining waveform.

However, in the case of the MV waveform of the eyelid, the amount of information included in the waveform MV of the remaining component remaining as a result of offsetting the waveform component corresponding to the waveform of the electrocardiogram from the MV waveform is too small. There was found.
That is, even if MV was measured with the eyelid, it was found that it is difficult to clearly grasp the health state and disease state of the living body based on the MV waveform.

[Relationship between Patent Document 1 and “Problem to be Solved by the Invention”]
In Patent Document 1 (nearest prior art), by measuring skin impedance using a well (out of the five holes) as a measurement point, the well (the 24 acupuncture points defined as fingers and toes only) The skin impedance has been measured.
However, the embodiment in Patent Document 1 aims to detect the balance between sympathetic nerves and parasympathetic nerves, and is related to diseases associated with cell growth control (such as tumors and cysts) and precursors of these diseases. It is not intended to diagnose the condition (see paragraphs [0082] to [0087]).

[Relationship between Non-Patent Document 5 and “Solution Problems of Present Invention”]
Non-Patent Document 5 discloses an MV waveform (eyelid, parietal, thumb ball) and electrocardiogram waveform of a subject with complete atrial block disease as shown in FIG. 14 in the present application.
And in nonpatent literature 5, as shown in FIG. 14 in this application, based on the waveform by electrocardiogram measurement based on the MV waveform measured by the thumb ball, the eyelid, the frontal region, the parietal region, etc. of the measurement subject's hand It is disclosed that a heart disease is diagnosed as well.
However, this embodiment in Non-Patent Document 5 can also be understood as a technique for replacing electrocardiogram waveform measurement by MV waveform measurement, diseases associated with cell proliferation control (tumor, cyst, etc.), and It is not intended to diagnose the precursor state of these diseases (see paragraphs [0107] to [0109]).

[Novelty and inventive step of the “solution to solve the present invention”]
As a result of promoting earnest study, the inventor of the present application,

(1) An experimental hypothesis that the anatomical location where MV strongly appears on the skin has a correlation with medical problems inside the body, and
(2) Experimental hypothesis that the amplitude intensity of MV shows a positive correlation with the magnitude of the medical problem

(Paragraphs [0102] to [0105]).

The inventors of the present application, now, by demonstrating the experiment hypothesis was conceived anew, in order to develop a new ground of entirely novel MV diagnosis technology, a result of promoting an extensive study, so to speak, as constructive "negative data" ,

Prior art in which measurement points are determined on the thumb ball, eyelid, frontal head, top of head, etc. of the measurement subject's hand, at least one point is selected, and the MV of the skin is measured (Non-patent Document 5)

Therefore, the amount of information included in the MV is too small, and it has become a new finding that it is difficult to clearly grasp the health state and disease state of a living body.

The inventor of the present application, based on the above-mentioned valuable knowledge that can be said to be constructive “negative data”, further promoted earnest studies, and as a result, from the five specific holes and a specific area around the newly discovered by the inventor. Based on the detected MV information, “positive data” that can contribute to disease diagnosis has been obtained.
Here, the MV information includes a waveform, vibration amount, amplitude, and frequency related to MV as a wave.
Here, the disease includes diseases related to cell growth control (such as tumors and cysts) and precursor states of these diseases.
In the prior art, trying to measure MV at the meridians and / or acupoints is insane and uncommon for those skilled in the art.
In addition, it was completely unexpected for those skilled in the art to measure MV in the five-line hole and / or the peripheral region of the five-line hole, which is a subordinate concept of meridians and acupoints.

Therefore, it can be said that not only the invention of the present application but also the “solution problem of the invention of the present application” has novelty and inventive step.

[Relationship between Patent Document 2 and “Solution Problems of Present Invention”]
In Patent Document 2 (nearest prior art), MV is measured for a thumb ball that is not included in the category of five holes.
However, since the measurement site | part of patent document 2 is a thumb ball and does not include a five-hole, the invention specific matter differs from this invention.
In Patent Document 2, as an effect of the invention, application of each symptom to clinical, diagnosis, treatment, etc., more specifically, treatment of autonomic symptom, psychosomatic disorder, irritable bowel syndrome, bronchial asthma, diabetes, hypertension・ Application of treatment evaluation and evaluation of drug effects of tranquilizers and analgesics is disclosed.

However, in this Patent Document 2, there is no suggestion or disclosure regarding diseases (such as tumors and cysts) related to cell proliferation control by MV waveform measurement, and diagnosis of precursor states of these diseases.

Therefore, this inventor had to think that the factor which can change MV in a test subject body at the time of resting awakening is not a factor which exists outside a test subject body.
In addition, as described in paragraphs [0102] to [0105], since MV was found to be uniform at every measurement point on the body and not to show a change in amplitude value in the same way, I had to find the medical significance of the new MV.

As a result of scrutinizing the data disclosed in Patent Document 2 (nearest prior art), the inventor of the present application has found that the original authors did not recognize,

(1) An anatomical position where MV strongly appears on the skin has a correlation with medical problems inside the body, and
(2) The finding that the amplitude intensity of MV shows a positive correlation with the magnitude of the degree of medical problem

(Paragraphs [0102] to [0105]).

The present invention is specified by the matters described in “Claim 1” to “Claim 7” of “Claims”.

[Claims]



[Claim 1]

A biological reaction waveform information analyzing apparatus that measures a biological microvibration waveform generated by a living body and obtains the measured biological microvibration waveform.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, for n-th waveform of the measured biological Microvibration at measurement site represented by a natural number in the range of 1 to n _E, as shown in Equation (1), the time t amplitude f _n ( a vibration amount (F _n ) that is an integral value obtained by integrating t) in the time range from time t _{0 to} t _E ,


Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2),


While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2),
Based on Equation (4),
Calculate the vibration relative value (R _n ) which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min ),


Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;
A biological microvibration analyzer characterized by comprising:




[Claim 2]

A biological reaction waveform information analyzing apparatus that measures a biological microvibration waveform generated by a living body and obtains the measured biological microvibration waveform.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,

A first region of the hand as a first sub-measurement site;
That is,
At least two acupuncture points as the first region central acupuncture points (first main measurement site) of the selected hand as the center;
In the area within the circle drawn as the radius, the value of 1 / 160th the subject height value,
Two points facing each other at equal distances across the center,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,

A first region of the foot as a second sub-measurement site;
That is,
As a center, at least two acupuncture points as the first region central acupuncture point (second main measurement site) of the selected foot,
In the area within the circle drawn as the radius, the value of 1 / 160th the subject height value,
Two points facing each other at equal distances across the center,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,

A second region of the hand as a third sub-measurement site,
That is,
At least two acupuncture points as the second region central acupuncture points (third main measurement site) of the selected hand as the center;
In the area in the circle drawn as the radius, 1 / 10th the subject height value,
Two points facing each other at equal distances across the center,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,

A second region of the foot as a fourth sub-measurement site;
That is,
At least two acupuncture points as the second region central acupuncture points (fourth main measurement site) of the selected foot as the center;
In the area in the circle drawn as the radius, 1 / 10th the subject height value,
Two points facing each other equidistant across the center



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,

A third region of the hand as a fifth sub-measurement site;
That is,
With at least two acupuncture points as the third region central acupuncture points (fifth main measurement site) as the center of the selected hand;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,

A third region of the foot as a sixth sub-measurement site;
That is,
As a center, at least two acupoints as the third region central acupuncture points (sixth main measurement site) of the selected foot,
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other equidistant across the center



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,

A fourth region of the hand as a seventh sub-measurement site;
That is,
At least two acupuncture points as the fourth region central acupuncture points (seventh main measurement site) of the selected hand as the center;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,

A fourth region of the foot as an eighth sub-measurement site;
That is,
At least two acupuncture points as the fourth region central acupuncture points (eighth main measurement site) of the selected foot as the center;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other equidistant across the center



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,

A fifth region of the hand as a ninth sub-measurement site;
That is,
At least two acupuncture points as the fifth region central acupuncture points (9th main measurement site) as the center of the selected hand,
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A fifth region of the foot as a tenth secondary measurement site,
That is,
As a center, at least two acupuncture points as the fifth region central acupuncture points (tenth main measurement site) of the selected foot,
In the area in the circle drawn as the radius, the value of one-fourth of the subject's height value,
Two points facing each other equidistant across the center

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, for n-th waveform of the measured biological Microvibration at measurement site represented by a natural number in the range of 1 to n _E, as shown in Equation (1), the time t amplitude f _n ( a vibration amount (F _n ) that is an integral value obtained by integrating t) in the time range from time t _{0 to} t _E ,


Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2),


While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2),
Based on Equation (4),
Calculate the vibration relative value (R _n ) which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min ),


Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;
A biological microvibration analyzer characterized by comprising:




[Claim 3]

A biodiagnosis support device for measuring a waveform of a biological microvibration generated by a living body and based on biological response waveform information obtained from the measured waveform of the biological microvibration.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, for n-th waveform of the measured biological Microvibration at measurement site represented by a natural number in the range of 1 to n _E, as shown in Equation (1), the time t amplitude f _n ( a vibration amount (F _n ) that is an integral value obtained by integrating t) in the time range from time t _{0 to} t _E ,


Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2),


While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2),
Based on Equation (4),
Calculate the vibration relative value (R _n ) which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min ),


Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;

The vibration amount relative value (R _n ) for each measurement site represented as a list obtained by the second means is expressed as follows:
Based on Equations (5) to (7),
A first region total vibration amount relative value (R _I ) as a total value of vibration amount relative values (R _n ) belonging to the first region;
Second region total vibration amount relative value (R _II ) as a total value of vibration amount relative values (R _n ) belonging to the second region,
Third and subsequent total vibration amount relative values (R _{III to V} ) as a total value of vibration amount relative values (R _n ) belonging to the third to fifth regions
A third means for calculating


The first region total vibration amount relative value (R _I ), the second region total vibration amount relative value (R _II ), and the third and subsequent region total vibration amount relative values (R _{III to} ) calculated by the third means. _V )
Based on Equation (8), a second region amplitude concentration index (CD) that is an index of the degree of concentration of biological microvibration on the second region is calculated and displayed.



And / or

Fourth means for calculating and displaying a biological microvibration fluctuation index (VD) that is an index of the magnitude of fluctuation of the biological microvibration in the entire region based on the mathematical formula (9).

A biodiagnosis support device comprising:




[Claim 4]


A biodiagnosis support device for measuring a waveform of a biological microvibration generated by a living body and based on biological response waveform information obtained from the measured waveform of the biological microvibration.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,

A first region of the hand as a first sub-measurement site;
That is,
At least two acupuncture points as the first region central acupuncture points (first main measurement site) of the selected hand as the center;
In the area within the circle drawn as the radius, the value of 1 / 160th the subject height value,
Two points facing each other at equal distances across the center,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,

A first region of the foot as a second sub-measurement site;
That is,
As a center, at least two acupuncture points as the first region central acupuncture point (second main measurement site) of the selected foot,
In the area within the circle drawn as the radius, the value of 1 / 160th the subject height value,
Two points facing each other at equal distances across the center,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,

A second region of the hand as a third sub-measurement site,
That is,
At least two acupuncture points as the second region central acupuncture points (third main measurement site) of the selected hand as the center;
In the area in the circle drawn as the radius, 1 / 10th the subject height value,
Two points facing each other at equal distances across the center,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,

A second region of the foot as a fourth sub-measurement site;
That is,
At least two acupuncture points as the second region central acupuncture points (fourth main measurement site) of the selected foot as the center;
In the area in the circle drawn as the radius, 1 / 10th the subject height value,
Two points facing each other equidistant across the center



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,

A third region of the hand as a fifth sub-measurement site;
That is,
With at least two acupuncture points as the third region central acupuncture points (fifth main measurement site) as the center of the selected hand;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,

A third region of the foot as a sixth sub-measurement site;
That is,
As a center, at least two acupoints as the third region central acupuncture points (sixth main measurement site) of the selected foot,
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other equidistant across the center



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,

A fourth region of the hand as a seventh sub-measurement site;
That is,
At least two acupuncture points as the fourth region central acupuncture points (seventh main measurement site) of the selected hand as the center;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,

A fourth region of the foot as an eighth sub-measurement site;
That is,
At least two acupuncture points as the fourth region central acupuncture points (eighth main measurement site) of the selected foot as the center;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other equidistant across the center



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,

A fifth region of the hand as a ninth sub-measurement site;
That is,
At least two acupuncture points as the fifth region central acupuncture points (9th main measurement site) as the center of the selected hand,
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A fifth region of the foot as a tenth secondary measurement site,
That is,
As a center, at least two acupuncture points as the fifth region central acupuncture points (tenth main measurement site) of the selected foot,
In the area in the circle drawn as the radius, the value of one-fourth of the subject's height value,
Two points facing each other equidistant across the center

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, for n-th waveform of the measured biological Microvibration at measurement site represented by a natural number in the range of 1 to n _E, as shown in Equation (1), the time t amplitude f _n ( a vibration amount (F _n ) that is an integral value obtained by integrating t) in the time range from time t _{0 to} t _E ,


Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2),


While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2),
Based on Equation (4),
Calculate the vibration relative value (R _n ) which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min ),


Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;

The vibration amount relative value (R _n ) for each measurement site represented as a list obtained by the second means is expressed as follows:
Based on Equations (5) to (7),
A first region total vibration amount relative value (R _I ) as a total value of vibration amount relative values (R _n ) belonging to the first region;
Second region total vibration amount relative value (R _II ) as a total value of vibration amount relative values (R _n ) belonging to the second region,
Third and subsequent total vibration amount relative values (R _{III to V} ) as a total value of vibration amount relative values (R _n ) belonging to the third to fifth regions
A third means for calculating


The first region total vibration amount relative value (R _I ), the second region total vibration amount relative value (R _II ), and the third and subsequent region total vibration amount relative values (R _{III to} ) calculated by the third means. _V )
Based on Equation (8), a second region amplitude concentration index (CD) that is an index of the degree of concentration of biological microvibration on the second region is calculated and displayed.



And / or

Fourth means for calculating and displaying a biological microvibration fluctuation index (VD) that is an index of the magnitude of fluctuation of the biological microvibration in the entire region based on the mathematical formula (9).


A biodiagnosis support device comprising:




[Claim 5]

A biodiagnosis support device for measuring a waveform of a biological microvibration generated by a living body and based on biological response waveform information obtained from the measured waveform of the biological microvibration.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, for n-th waveform of the measured biological Microvibration at measurement site represented by a natural number in the range of 1 to n _E, as shown in Equation (1), the time t amplitude f _n ( a vibration amount (F _n ) that is an integral value obtained by integrating t) in the time range from time t _{0 to} t _E ,


Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2),


While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2),
Based on Equation (4),
Calculate the vibration relative value (R _n ) which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min ),


Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;

The vibration amount relative value (R _n ) for each measurement site represented as a list obtained by the second means is expressed as follows:
Based on Equations (5) to (7),
A first region total vibration amount relative value (R _I ) as a total value of vibration amount relative values (R _n ) belonging to the first region;
Second region total vibration amount relative value (R _II ) as a total value of vibration amount relative values (R _n ) belonging to the second region,
Third and subsequent total vibration amount relative values (R _{III to V} ) as a total value of vibration amount relative values (R _n ) belonging to the third to fifth regions
A third means for calculating


The first region total vibration amount relative value (R _I ), the second region total vibration amount relative value (R _II ), and the third and subsequent region total vibration amount relative values (R _{III to} ) calculated by the third means. _V )
Based on Equation (8), a second region amplitude concentration index (CD) that is an index of the degree of concentration of biological microvibration on the second region is calculated,



A fourth means for calculating a biological microvibration fluctuation index (VD), which is an index of the magnitude of fluctuation of the biological microvibration in the entire region, based on the mathematical formula (9);


The biomicrovibration variability index (VD) value calculated by the fourth means is collated with a calibration curve based on a regression equation between the biomicrovibration variability index (VD) and the serum concentration of the serum tumor marker, Fifth means for predicting serum concentration of serum tumor marker

A biodiagnosis support device comprising:




[Claim 6]


A biodiagnosis support device for measuring a waveform of a biological microvibration generated by a living body and based on biological response waveform information obtained from the measured waveform of the biological microvibration.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,

A first region of the hand as a first sub-measurement site;
That is,
At least two acupuncture points as the first region central acupuncture points (first main measurement site) of the selected hand as the center;
In the area within the circle drawn as the radius, the value of 1 / 160th the subject height value,
Two points facing each other at equal distances across the center,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,

A first region of the foot as a second sub-measurement site;
That is,
As a center, at least two acupuncture points as the first region central acupuncture point (second main measurement site) of the selected foot,
In the area within the circle drawn as the radius, the value of 1 / 160th the subject height value,
Two points facing each other at equal distances across the center,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,

A second region of the hand as a third sub-measurement site,
That is,
At least two acupuncture points as the second region central acupuncture points (third main measurement site) of the selected hand as the center;
In the area in the circle drawn as the radius, 1 / 10th the subject height value,
Two points facing each other at equal distances across the center,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,

A second region of the foot as a fourth sub-measurement site;
That is,
At least two acupuncture points as the second region central acupuncture points (fourth main measurement site) of the selected foot as the center;
In the area in the circle drawn as the radius, 1 / 10th the subject height value,
Two points facing each other equidistant across the center



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,

A third region of the hand as a fifth sub-measurement site;
That is,
With at least two acupuncture points as the third region central acupuncture points (fifth main measurement site) as the center of the selected hand;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,

A third region of the foot as a sixth sub-measurement site;
That is,
As a center, at least two acupoints as the third region central acupuncture points (sixth main measurement site) of the selected foot,
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other equidistant across the center



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,

A fourth region of the hand as a seventh sub-measurement site;
That is,
At least two acupuncture points as the fourth region central acupuncture points (seventh main measurement site) of the selected hand as the center;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,

A fourth region of the foot as an eighth sub-measurement site;
That is,
At least two acupuncture points as the fourth region central acupuncture points (eighth main measurement site) of the selected foot as the center;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other equidistant across the center



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,

A fifth region of the hand as a ninth sub-measurement site;
That is,
At least two acupuncture points as the fifth region central acupuncture points (9th main measurement site) as the center of the selected hand,
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A fifth region of the foot as a tenth secondary measurement site,
That is,
As a center, at least two acupuncture points as the fifth region central acupuncture points (tenth main measurement site) of the selected foot,
In the area in the circle drawn as the radius, the value of one-fourth of the subject's height value,
Two points facing each other equidistant across the center

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, for n-th waveform of the measured biological Microvibration at measurement site represented by a natural number in the range of 1 to n _E, as shown in Equation (1), the time t amplitude f _n ( a vibration amount (F _n ) that is an integral value obtained by integrating t) in the time range from time t _{0 to} t _E ,


Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2),


While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2),
Based on Equation (4),
Calculate the vibration relative value (R _n ) which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min ),


Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;

The vibration amount relative value (R _n ) for each measurement site represented as a list obtained by the second means is expressed as follows:
Based on Equations (5) to (7),
A first region total vibration amount relative value (R _I ) as a total value of vibration amount relative values (R _n ) belonging to the first region;
Second region total vibration amount relative value (R _II ) as a total value of vibration amount relative values (R _n ) belonging to the second region,
Third and subsequent total vibration amount relative values (R _{III to V} ) as a total value of vibration amount relative values (R _n ) belonging to the third to fifth regions
A third means for calculating


The first region total vibration amount relative value (R _I ), the second region total vibration amount relative value (R _II ), and the third and subsequent region total vibration amount relative values (R _{III to} ) calculated by the third means. _V )
Based on Equation (8), a second region amplitude concentration index (CD) that is an index of the degree of concentration of biological microvibration on the second region is calculated,



A fourth means for calculating a biological microvibration fluctuation index (VD), which is an index of the magnitude of fluctuation of the biological microvibration in the entire region, based on the mathematical formula (9);



The biomicrovibration variability index (VD) value calculated by the fourth means is collated with a calibration curve based on a regression equation between the biomicrovibration variability index (VD) and the serum concentration of the serum tumor marker, Fifth means for predicting serum concentration of serum tumor marker

A biodiagnosis support device comprising:

An outline of the present invention will be described below as means for solving the problems.

[First feature of the present invention]
The first feature of the present invention is an apparatus for analyzing biological reaction waveform information obtained by measuring a waveform of a biological microvibration generated by a biological living body and obtained from the measured waveform of the biological microvibration.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, the n th measurement site represented by a natural number within the range of 1 to n _E
The integral obtained by integrating the amplitude f _n (t) at the time t in the time range from the time t ₀ to the time t _E with respect to the measured biological microvibration waveform, as shown in the equation (1).
Calculate the amount of vibration (F _n ),
Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2) ,
While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2) ,
Based on Equation (4),
The vibration amount phase which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min )
Calculate the pair value (R _n )
Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above ,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;
It is to comprise.

[Second feature of the present invention]
A second feature of the present invention is a biodiagnosis support device that measures a waveform of a biological microvibration generated by a living body and is based on biological reaction waveform information obtained from the measured waveform of the biological microvibration.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, the n th measurement site represented by a natural number within the range of 1 to n _E
The integral obtained by integrating the amplitude f _n (t) at the time t in the time range from the time t ₀ to the time t _E with respect to the measured biological microvibration waveform, as shown in the equation (1).
Calculate the amount of vibration (F _n ),
Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2) ,
While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2) ,
Based on Equation (4),
The vibration amount phase which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min )
Calculate the pair value (R _n )
Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above ,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;

The vibration amount relative value (R _n ) for each measurement site represented as a list obtained by the second means is expressed as follows :
Based on Equations (5) to (7),
A first region total vibration amount relative value (R _I ) as a total value of vibration amount relative values (R _n ) belonging to the first region ;
Second region total vibration amount relative value (R _II ) as a total value of vibration amount relative values (R _n ) belonging to the second region ,
Total after the third region as the total value of the vibration amount relative values (R _n ) belonging to the third region to the fifth region
Relative vibration value (R _{III ~ V} )
A third means for calculating
First region total vibration amount relative value (R _I ) and second region total vibration amount calculated by the third means
Relative value (R _II ) and total vibration amount relative value (R _{III ~ V} ) from the third region onward ,
Based on Equation (8), a second region amplitude concentration index (CD) that is an index of the degree of concentration of biological microvibration on the second region is calculated and displayed.

And / or

Fourth means for calculating and displaying a biological microvibration fluctuation index (VD), which is an index of the magnitude of fluctuation of the biological microvibration in the entire region, based on Equation (9)

It is to comprise.

[Third feature of the present invention]
According to a third feature of the present invention, in the MV information analyzer of the first feature and the biodiagnosis support device of the second feature, the serum tumor marker is:
It is at least one selected from the group consisting of CEA, CA15-3, CA19-9, BCA, and NCC-ST-439.

If the MV measurement value is analyzed using the means described in the first to third features of the present invention, the MV appearing on the body skin has a difference in vibration amount at different parts of the body depending on the health condition of the subject. You can grasp that there is a nature to produce.

At the time of MV measurement, medical information such as blood test information, blood pressure information, and medical diagnosis name of the subject is grasped in advance by the work of a doctor or the like.
A database is created by comparing the medical information obtained in advance with the information related to the MV vibration amount obtained by the MV analysis apparatus of the present invention and associating them with each other.

In actual clinical practice, based on this database, the MV obtained non-invasively for new subjects is analyzed as needed to provide information on the health status of these new subjects to doctors, etc. It can be provided as information.

The diagnostic support information provided is

(1) A vibration amount score table, which is a list of classified and displayed MV measurement values for each body location and meridian for the purpose of obtaining a positional distribution pattern of the MV vibration amount of the subject.

(2) The bar graph which displayed the total result of the vibration amount score table | surface of said (1) in order to obtain | require the positional distribution pattern of a test subject's MV vibration amount.

(3) A frequency distribution table and a histogram obtained by performing statistical analysis on the total results of the vibration amount score table of (1) described above for the purpose of obtaining a statistical distribution tendency of the positional distribution pattern of the MV vibration amount of the subject.

(4) serving total value of the living micro-vibration amount of vibration was concentrated in the second region of the subject, "second region (R) sum: (R _II)".

(5) “Second region (R) concentration degree: CD” indicating the degree of concentration of the biological microvibration vibration of the subject in the second region as a ratio.

(6) “MV fluctuation index value: VD” indicating a correlation with the tumor marker value.

(7) Time-series change graph of the subject's “MV fluctuation index value: VD” and the slope of this graph.

7 information.

Next, (1) to (7) of these biological support information will be described.

["Vibration amount score table" as diagnostic support information]
The “vibration amount score table” mentioned in the paragraph (1) of the paragraph [0121] is a table described in the paragraph [0045] and exemplified in Tables 8 to 10.
For example, as shown in Table 9, the amplitude score table is created with the classification of the 12th meridian based on the Oriental medicine theory, so the MV vibration obtained from the upper limb and lower limb of the subject is used. The quantity can be taken from the concept of Oriental medicine and analyzed.
Further, as in the amplitude score table illustrated in FIG. 9, the symbols input to the cells in the table, that is,
"Light red background" (indicating maximum value),
"◎",
“○”,
“△”,
"-",
"" (Shown blank),
Are given by the operations described later in paragraph [0182], and the symbols “◎”, “O”, “Δ”, “−”, or “” (“−”) are given in descending order of vibration amount. By applying and converting the numerical value of the vibration amount, it is easy for a doctor or the like who wants to obtain the diagnosis support device by looking at this to visually recognize the vibration amount distribution state of the MV.

Further, in this amplitude score table (Table 10), those having a low relative numerical value of the MV vibration amount are rounded down, and “-” indicating a blank is input to make it easier to visually recognize.

The amplitude score table has a format in which each region center acupuncture point and each region marginal acupuncture point are combined.
In the specification of the present invention, when this amplitude score table is used for explaining the MV vibration amount, the measurement data of the right hand part is shown separately for convenience of explanation and ease of visual recognition. .

["Bar graph" as diagnostic support information]
The bar graph referred to in paragraph [0121] (2) is, for example, a graph illustrated in FIGS.
This bar graph can monitor how the subject's MV changes according to the distance from the fingertip, as described in FIG. 17 in paragraph [0102].

The bar graphs illustrated in FIGS.
The MV measurement value obtained from the five acupuncture points is logarithmically calculated to obtain the vibration amount relative value (R).
Take this R value as the y value on the y-axis of the graph,
The distance from the fingertip to the measurement position is generated as an x-axis value.

In this specification, when this bar graph is used for explaining the MV vibration amount, the measurement data of the right part of the subject is shown in consideration of the convenience of explanation and ease of visual recognition.

[From subject Naitak's case]
The subjects of the three bar graphs shown in FIGS. 18 to 20 are male subjects who underwent tumor resection surgery and lymph node dissection surgery around the tumor due to primary colorectal cancer that developed in the sigmoid colon in October 2001. (65 years old). This subject is tentatively called Naitak.
Three years after this surgery, it reached June 10, 2004, and was subject to prediction by the MV measurement value analyzer of the present invention. From the analysis results obtained, the subject's constitution was control of cell growth such as tumors and cysts. It is the example which obtained the prediction result that it may be in the disease which is related to and / or the precursor state of these diseases. Serum tumor marker value at the time of MV measurement is CEA; 5.0 (cut-off value = 5.0),
Ca19-9; 23.0 (cutoff value = 37.0)
However, the surgeon in charge did not diagnose metastatic cancer because it was judged that there was insufficient evidence of metastatic cancer.
However, six months later, in December 2004, a thin shadow with a diameter of about 5 mm was found at the apex of the upper left and right lungs by chest radiography.
Furthermore, one month later, in January 2005, a 1-cm shadow was obtained at the same site by chest radiography. As a result, cytodiagnosis was performed. He was diagnosed and underwent endoscopic tumor resection at the end of February 2005.
The position of the tumor that metastasized to the left lung apex was the same as the predicted position of the lesion predicted using the analyzer according to the present invention.
Next, the meaning of the bar graph will be described.

The bar graph shown in FIG. 18 is an MV record when this male subject Naitak visited on June 10, 2004.
The bottom of the graph is divided into five areas by double arrows.
In each of these five areas, the bar graph stands in three sections. The center of each of the three divisions represents the measured value of the region center acupuncture point, the left of the central acupuncture point represents the measured value of the fingertip side region marginal acupuncture point, and the right of the central acupuncture point represents the trunk side (the center of the body This is because the measured value of the region margin acupuncture point (which means the near side) is shown.

In the record of June 10, 2004 shown in FIG. 18, MV appears in the entire five areas, but in particular, the MV in the second area is large, and the measured values of the central acupuncture points in the second area are particularly concentrated. It can be seen that a large amount of vibration was recorded.
The medical illness at this time, as mentioned in the previous section, was lymph node dissection depending on the condition that the metastasis was seen in the lymph node after undergoing surgery for primary colorectal cancer three years ago. Since 3 years ago, cancer cell metastasis has started by spreading through lymph nodes and lymph vessels, which is called lymphatic metastasis. It was predicted that cancer cells could be transported in the future.
Serum tumor marker values at this point are as described in the previous section.
CEA; 5.0 (cutoff value = 5.0),
Ca19-9; 23.0 (cutoff value = 37.0)
However, the attending physician in charge of surgery was unable to diagnose the presence of metastases on the basis that CT metastases were not found.

The MV recording shown in FIG. 18 and the MV measurement value analysis data after elapse of time are compared in time series, and described in paragraph (7) of paragraph [0121].
“Subject's“ MV fluctuation index value: VD ”time-series change graph and slope of this graph”
The slope showed a positive slope.
In other words, diagnostic support information was obtained that presumed that the tumor marker value would have increased.
This diagnosis support information is shown in FIG.
FIG. 24 is “Study on tumor marker and MV fluctuation index value” for subject Naitak.
According to “time-series change of MV fluctuation index value” shown in (3) of FIG. 24, the graph of “MV fluctuation index value” continuously has a positive slope.
The gradient shown in (3) of FIG.
Graph date: From "2004 (Heisei 16) July 12 to July 13"
Graph date: “January 17 to February 9, 2005”
Continued to rise.

On the other hand, according to “time series change of CEA value” shown in FIG. 24 (4), the CEA value is
Graph date: "December 5-December 14, 2004 (Heisei 16)"
The value is temporarily low at the time of MV analysis.

The low value temporarily shown at the time of MV analysis of “2004 (Heisei 16) December 14 to December 14” is a result of the subject Naitak receiving an anticancer drug at the recommendation of the attending physician. It was speculated that this was a result of the tumor becoming smaller.

However, metastatic carcinoma in the lung has expanded immediately afterward.
for that reason,
Graph date: "December 5-December 14, 2004 (Heisei 16)"
Only two months later, in February 2005, he had to undergo resection.

This fact shows that even though the subject Naitak was successfully administered an anti-cancer drug and succeeded in temporarily reducing the size of the malignant tumor, the so-called “cancerous constitution” has not changed at all, and the disease symptoms Should have been seen as having been deteriorating in invisible parts of the body.
Therefore, the inventor of the present application has found that the slope of the “time-series change of MV fluctuation index value” graph is indispensable for grasping the correct disease state of cancerous disease and is extremely important diagnosis support information.

In addition, when examination is made also from “relation between subject“ MV fluctuation index value: VD ”and inflammatory disease” described later in paragraphs [0157] to [0161], this subject Naitak has inflammatory disease. Since there was not, the slope of the comparison graph in the obtained time series was sufficient diagnostic support information to doubt the worsening of the cancerous disease.

FIG. 19 shown next is an MV record when the subject Naitak visited on December 5, 2004.
Comparing this record with the June 10 record, it can be seen that the vibration amount in the fifth region of the five regions is the lowest value, and the vibration amount in the fourth region is also reduced.
In contrast, the amount of vibration increased in the third region.
In particular, the amount of vibration in the second region almost shows a relatively high value at the central acupuncture point, and the amount of vibration has similarly increased at the fingertip side and the trunk side of the marginal acupuncture point. Was showing.

At this time, as described in the previous stage, the medical illness in December 2004 showed a faint shadow with a diameter of about 5mm in the apex of the upper left and right lungs by chest radiography. At the time of inspection on December 14,
CEA; 5.4 ng / ml,
CA19-9; 24.0 ng / ml
And

Compared to the June 10 value,
0.5 ng / ml increase,
1.0 ng / ml increase,
Was.

This increase in serum tumor marker value was, of course, data that could predict tumor expansion.
Subject Naitak received MV analysis on December 5, 2004, and in February 2005, received endoscopic lung cancer resection.

FIG. 20 shown next is an MV record when the subject Naitak visited on October 17, 2005.
Comparing this record with the record of December 5, 2004, it can be seen that the vibration amount in the fifth region, the fourth region, and the third region among the five regions is the lowest value. .
In contrast, the amount of vibration increased significantly in the second region.
In particular, the vibration amount of the second region center acupuncture point is such that the vibration amount relative value is a high value of 8 or more in all the meridian center meridian points.
On the other hand, the amount of vibration of the second region offset acupuncture points is generally low.
At this time, the medical illness on October 17, 2005
CEA; 39.1 ng / ml (cut-off value = 5.0),
CA19-9; 453.0 ng / ml (cutoff value = 37.0)
It has been shown that metastasis and spread of malignant tumors is a more serious situation.

Subject Naitak was able to visit our hospital last on October 17, 2005. When he received a visit on April 20, 2006, he had already had severe ascites. Immediately hospitalized. After that, he was breathed in early morning on May 4.

[From subject Nakmit's case]
Next, the subjects of the three bar graphs shown in FIGS. 21 to 23 are male subjects who have undergone lymph node dissection surgery for metastasis to the right subclavian lymph node in 2003 after excision surgery for esophageal cancer in 2002. (63 years old). This subject is tentatively called Nakmit.

Subject Nakmit has been continuing radiotherapy for 3 years intermittently, but until 2006, he was diagnosed with a recurrence of malignant tumors in the esophageal anastomosis (joining) section and thoracic esophagus.
Since the cumulative radiation dose exceeded the upper limit, the attending physician determined that further radiotherapy was impossible, and the patient was followed up on June 18, 2007.
At the time of the visit, there were 3 small and large cancerous lesions in the above site.

In the MV recording of the subject Nakmit shown in FIG. 21 on June 18, 2007, the amount of vibration in the second region was large from the beginning, and only the central acupuncture point protruded to show a large amount of vibration.
At this time, the medical illness around June 18, 2007 was
CEA; 5.5 (cutoff value = 5.0),
Met.

This subject, Nakmit, has been pointed out by both of the two university hospitals already involved in the risk of further radiation treatment, and the use of additional anti-cancer drugs was restricted based on the degree of leukocyte reduction. The situation was just to observe the course of the disease.

Therefore, the subject Nakmit was forced to seek oriental medical means because of the limited possible medical means such as anti-cancer drugs in general medical common sense. Naturally, herbal medicine options were included.

Therefore, the inventor of the present application examines herbal medicine selection based on the diagnosis support device of the disease prediction system of the present invention, and seeks to respond to the request of the subject Nakmit after consulting with a collaborating doctor and pharmacist. It was.

FIG. 22 is an MV record when approximately one month has passed after the first visit of subject Nakmit.
Comparing this bar graph with the above-mentioned record of June 18, 2007, the upper limit of the amount of vibration that was concentrated only at the central acupuncture point in the second region at the first visit was reduced, and the fingertip side of the marginal acupuncture point A large amount of vibration appears in.
Furthermore, since a vibration amount appears on the trunk side of the marginal acupuncture point in the first region, the peak of the vibration amount was recorded as if it moved on the body.

The next FIG. 23 is an MV record when the subject Nakmit visited the hospital on February 11, 2008, the year after the first visit.
According to this record, the vibration amount that was initially extremely high in the central acupuncture point of the second region began to show a low value except for the four meridians, while the third region and the fourth region The amount of vibration has increased.
At this time, the medical illness situation around February 11, 2008,
CEA; 3.0 (cutoff value = 5.0),
Met.
And shortly after this, subject Nakmit received from his attending physician,
“As a result of CT tomography, 3 lesions disappeared,”
I was diagnosed with.

The clinical example of the subject Nakmit shown here also showed that the diagnosis support information of the present invention is significant.

In the example of subject Naitak, the progress of cancerous disease was monitored by MV recording.
On the other hand, in the example of the subject Nakmit, the progress of improvement of the cancerous disease was similarly monitored.
Comparing these contrasting MV records for malignant tumors,
The change of the distribution pattern that occurs in the vibration amount distribution graph when the cancerous disease gets worse is
When the degree of cancerous disease is still mild, the vibration distribution peak is in the central acupuncture point of the second region, but the vibration amount distribution is also seen in other regions other than the second region,
Thereafter, as the cancerous disease worsens, the peak of the vibration distribution in the second region increases, and the vibration amount distribution observed in other regions other than the second region gradually concentrates near the second region. There was a trend.

On the other hand, the change of the distribution pattern that occurs in the vibration amount distribution graph when the cancerous disease is improving,
If the degree of cancerous disease is not yet improved, the vibration distribution is gradually concentrated near the second region.
Then, as the cancerous disease improves, the vibration amount distribution peak appears in the second region, but the vibration amount distribution appears in other regions other than the second region.
Is characteristic,
Further, for example, as shown in FIG. 23, when the cancerous disease starts to improve significantly as in the case of the subject Nakmit on February 11, 2008, the amount of vibration that appeared in the central acupuncture point in the second region was high. There was a feature that some values disappeared and a large distribution of vibration values was observed in other regions other than the second region.

Summarizing the two cases described in paragraphs [0127] to [0143] and describing the characteristic MV phenomenon found in cancerous diseases, the following points can be mentioned.

(1) The change in the distribution pattern that occurs in the vibration amount distribution graph when the cancerous disease tends to deteriorate is that the value of the vibration amount relative value (R) in the second region gradually increases, and the high amplitude There were two features that the part was concentrated in the second region.

(2) The change in the distribution pattern in the vibration amount distribution graph when the cancerous disease tends to be improved is that the vibration amount relative value (R) in the second region gradually decreases, and the high amplitude There were two characteristics, that is, the state where the part was concentrated in the second region changed to a state where the high-amplitude part moved to another region other than the second region.

Thus, it has become necessary to examine whether or not the degree of progression of cancerous disease and the degree of change in the MV distribution pattern show a positive correlation.
For this examination, it was necessary to examine the correlation between the serum tumor marker value used as an index for monitoring the disease progression state of the cancerous disease and the MV vibration amount distribution state.

From the change tendency of the bar graph mentioned above, it is related to the disease state of cancerous disease,

(1) the magnitude of the MV vibration amount in the second region;

(2) The degree to which MV appears in a concentrated manner in the second region among the five regions,

It was.

Regarding (1), since the second region vibration amount relative value (R) is input and temporarily stored in the vibration amount score table described in detail in paragraph [0045], the second region vibration amount relative value (R) is temporarily stored. Values can be used.

For (2), according to equations (5) to (7) in paragraph [0048]
“R _II ” (total value in the second region of vibration amount relative value (R)),
“R _I ” + “R _{III ~ V} ” (total value in all other areas except the second area)
And
A value generated based on this ratio can be used.

Formula (8) for obtaining this ratio as “second region (R) concentration degree: CD” is as already described in paragraph [0051].

The coefficient “κ” used in Equation (8) for obtaining “second region (R) concentration degree: CD” will be described.
The vibration amount score table shown in Table 14 is an “input example of vibration amount score table when the subject is a very healthy young person”.
When the measurement value analysis is performed by the MV analysis apparatus of the present application, as shown in Table 14, the vibration amount relative value (R) may be all entered as “1” in the vibration amount score table.

Judging from the clinical data of the present inventor so far, when the vibration amount relative value (R) of the subject is all input to the vibration amount score table as “1”, the subject is generally oriental. Theoretically, it is a completely healthy body.

Thus, when the MV shows a very low value in all the five regions, the subject is completely healthy, and in such a case, the high-amplitude portion of the MV does not appear in any region. .
When the vibration amount relative value (R) of the test subject is all entered as “1” in the vibration amount score table, the high-amplitude part of MV does not concentrate in any region. Become.
For this reason, when the vibration amount relative value (R) of the subject is all entered as “1” in the vibration amount score table, the second region (R) concentration degree is expressed as “1.00”. The (κ) of 8) was set to “4”.

As mentioned in the previous paragraph [0146]
From the change tendency of the bar graph, the MV characteristic related to the disease state of cancerous disease is
(1) the magnitude of the MV vibration amount in the second region;
(2) The degree to which MV appears in a concentrated manner in the second region among the five regions,
Because,
By multiplying the values of (1) and (2), an “MV fluctuation index value” indicating the relationship between the cancerous disease and the disease state is generated.
This MV trend index is expressed as “VD” and is obtained by Expression (9).

Recording serum tumor marker values obtained from subject Naitak,
The correlation with the MV recording performed at the date and time close to the serum tumor marker test date will be examined in a time series change.
FIG. 24 shows “Study on tumor marker and MV variation index value” and shows a correlation graph.
In (1) of FIG. 24, “Correlation between CEA value and MV fluctuation index value”
FIG. 24 (2) shows “Correlation between CA19-9 value and MV fluctuation index value”.
In these correlation graphs,
Set the above-mentioned MV fluctuation index value on the x-axis,
Determine the serum tumor marker value on the y-axis,
The correlation between the MV fluctuation index value and the serum tumor marker value was examined.
As a result, it became clear that the two were positively correlated.

Next, it was examined whether the correlation between the MV fluctuation index value and the serum tumor marker value exists in other subjects as well.
For cancerous diseases, as is generally recognized, such as a type of pancreatic cancer that is highly malignant and has a rapid tumor expansion, such as pancreatic cancer, generally has a relatively moderate degree of malignancy. Some types are known, such as breast cancer, or some have a relatively mild grade, such as thyroid cancer.
For such medical reasons, when examining whether the correlation between the MV variability index value and the serum tumor marker value exists in other subjects as well, all the data obtained are The examination was not performed with no distinction, but was classified according to the subject's cancer type.

The number of samples of the serum tumor marker value of the test subject used for examining the correlation between the MV fluctuation index value and the serum tumor marker value will be described.
Needless to say, testing for serum tumor markers is a costly patient test. In addition, because it is a blood test, it must be performed invasively, and the subject must have a kind of mental threshold different from noninvasive tests such as body weight measurement, body temperature measurement, or blood pressure measurement. Needless to say, this must be considered by the patient.
Today, medical institutions have been criticized for profit improvement, and medical institutions have repeatedly criticized that there are many tests.
In such a case, it is necessary to refrain from frequently requesting data for the purpose of obtaining clinical trial data as much as possible, and to obtain comparative data with the minimum number of examinations.
Therefore, blood test data that should be examined for time-series changes include those with a small number.

Examples of 6 cases are shown in FIGS. 24 to 29, and the correlation between the MV fluctuation index value and the serum tumor marker value was examined.
The disease state of the subject in FIG. 24 was primary colorectal cancer.
The disease state of the subject in FIG. 25 was primary esophageal cancer.
The disease state of the subject in FIG. 26 was pancreatic cancer.
The disease state of the subject in FIG. 27 was breast cancer.
The disease state of the subject in FIG. 28 was breast cancer.
In the subject of FIG. 29, the disease state was pancreatic cancer.
From these studies, it was found that the correlation between the MV variability index value and the serum tumor marker value was significant.

["Histogram" as diagnostic support information]
The “histogram” referred to in paragraph (3) of paragraph [0121] is, for example, a graph illustrated as FIG.
FIG. 30 is a “histogram representing a distribution of vibration amount relative values obtained from seven healthy young people with low possibility of cancerous disease”.

The histogram shown in FIG. 30 is created by the following steps.
(1) “Vibration amount relative value: (R)” is obtained from the MV measurement value.
(2) The statistical frequency distribution of “vibration amount relative value: (R)” obtained in (1) is obtained for each region.
(3) A histogram is obtained from this statistical frequency distribution.

In the histogram of FIG. 30, the y-axis value is determined as the vibration amount relative value (R).
Since one histogram is generated for each region, five histograms are generated in five regions.
Since the histogram statistically represents the vibration distribution state and distribution tendency of MV, by comparing and comparing the five histograms with each other, the MVs of all meridians of the normal and twelve meridians that exist in the five regions The amount of vibration can be compared.
In the specification of the present invention, when this histogram is used for the explanation of the MV vibration amount, the measurement data of the right hand portion is mainly presented separately for convenience of explanation and ease of visual recognition.

In general, a patient in whom a cancerous disease is found is recorded by diagnosing the type and stage of cancer according to the progress of cancer.
Simultaneously with the recording, MV analysis of the patient (subject) is performed, and the vibration amount relative value (R) distribution state of the patient (subject) is classified into cancer types and stages, and added to the database in advance. A histogram is obtained for each type of cancer and for each stage.

In the MV analysis of a new patient (subject), the vibration relative value (R) distribution data indicated by the histogram stored in advance in the database is compared with the same data obtained from the new patient (subject). Thus, it is possible to estimate the disease state of a new patient (subject).

FIG. 31 is a “histogram representing the distribution of relative vibration amount values obtained from 10 subjects whose cancerous disease is clearly worsening”.
The population of the histogram in FIG. 31 was involved in the medical facility to which the inventor belongs.

(1) a case of undergoing a tumor resection operation after receiving a diagnosis of an obvious cancerous disease;

(2) Cases of suspected metastasis after undergoing tumor resection surgery

10 cases combining (1) and (2) are used as a population.
Of these 10 cases, there are 4 surviving cases and 6 dead cases as of January 1, 2010.

The matters common to all of this population are:
In all cases, the subject's serum tumor marker level gradually increases,
That's what it means.

That is, it shows that the cancerous disease is getting worse in all cases.

The five histograms shown in FIG. 31 show vibration amount relative value (R) distribution states in the first region to the fifth region.
Of the five histograms related to the five regions in FIG. 31, the histogram of the second region is clearly different from the histograms of the other regions.
The inventor of the present application compared and examined these histograms,
“The relative vibration amount (R) when the malignant tumor is getting worse is uniformly high in the second region regardless of the type of cancer”
I found the phenomenon.

Next, the histogram shown in FIG. 30 is the “histogram representing the distribution of vibration amount relative values obtained from seven healthy young people with low possibility of cancerous disease” described in the previous paragraph [0155].

The population of the histogram of FIG. 30 is clearly 7 cases of young people aged 4 to 14 years who have no cancerous disease.
The inventor of the present application compared and examined these histograms,

(1) In a body that clearly has no cancerous disease, the vibration distribution of MV shows almost no difference in all five regions.

(2) The relative vibration amount value (R) appearing in all five regions is extremely low.

And found two phenomena.

From these histogram studies described in paragraphs [0155] to [0157], the results of the individual subjects conducted using the bar graphs described above are almost the same as the results, and the disease status of cancerous diseases The MV distribution pattern was found to have the same correlation even when the data range was expanded.

[Time series change graph as diagnosis support information]
24 to 29 shown in paragraph [0154], it was found that the time series change graph as the diagnosis support information is effective by comparing the time series change of the MV fluctuation index value for each disease. .

[Effect of the present invention]
The effect of the present invention is to provide a biodiagnosis support apparatus that contributes to the diagnosis of a disease based on MV information detected from the five holes and the surrounding specific area newly found by the inventor.
Here, the MV information includes a waveform, vibration amount, amplitude, and frequency related to MV as a wave.
Here, the disease includes diseases related to cell growth control (such as tumors and cysts) and precursor states of these diseases.
In the prior art, trying to measure MV at the meridians and / or acupoints is insane and uncommon for those skilled in the art.
In addition, it was completely unexpected for those skilled in the art to measure MV in the five-line hole and / or the peripheral region of the five-line hole, which is a subordinate concept of meridians and acupoints.
The position / arrangement of the five-row hole has been handed down since ancient times, and it is unique among the persons skilled in the field of oriental medicine, particularly those skilled in the field of oriental medical treatment such as acupuncture and sputum. It goes without saying that there is no need to wait.
However, in the conventional technology, the position / arrangement of the five holes is a part where the treatment action such as acupuncture and acupuncture is “INPUT”, and a part for obtaining “OUTPUT” from which information is obtained. As, it has hardly been recognized.
Barely, only in Patent Document 1, the skin impedance is measured in the wells included in the five holes.
However, the embodiment in Patent Document 1 aims to detect the balance between sympathetic nerves and parasympathetic nerves, and is related to diseases associated with cell growth control (such as tumors and cysts) and precursors of these diseases. It is not intended to diagnose the condition.
Patent Document 2 is not intended to diagnose diseases associated with cell growth control (such as tumors and cysts) and the precursor states of these diseases.
In other words, in the conventional technology, a five-hole is recognized as an “OUTPUT” site for obtaining information, and a disease related to cell proliferation control (tumor, cyst, etc.) based on a physical measurement value obtained from the five-hole. ), As well as technologies that contribute to the diagnosis of the precursor state of these diseases.

[Details of the effect of the present invention]
Of the 361 acupuncture points in the whole body, not only measuring 28 acupuncture points called wells defined only for fingers and toes, but also measuring more acupuncture points, By selecting the measurement values in the region center acupuncture points and the region deviation acupuncture points from the first region to the fifth region, and comparing the vibration amounts generated from the selected measurement values with each other. Thus, it has become possible to compare the health state and the disease state of a living body by a non-invasive means for analyzing and utilizing the measured value of the MV waveform.
Therefore, it has been clarified that the factor that can change the MV at rest awakening is related to the health condition inside the subject body.
Further, by adopting a vibration amount score table pattern in which vibration amount scores are displayed in the process of obtaining health state information indicated by a living body from MV waveform measurement values, at least the effects (1) to (7) can be achieved. It was.

(1) It has been clarified that the high-amplitude region where the MV at the time of resting and awakening shows a change in the vibration distribution distribution pattern of the MV by moving on the body depending on the health state or disease state of the body.

(2) The change of this pattern and the positional transition of the high-amplitude part were able to clarify the medical positional relationship in the whole body that moves between the WHO standard acupuncture points defined on the body. .

(3) Since the correlation between the physical health condition or disease state and the expression characteristics of MV can be grasped as a pattern change expressed by using the symbols etc., the amount of information included in the MV can be sufficiently It became possible to pull it out.

(4) Since the MV fluctuation index value showing a correlation with a serum tumor marker closely related to the degree of progression of cancerous diseases could be found, it became possible to monitor the deterioration tendency of cancerous diseases non-invasively. It was.

(5) Even when the cancerous tumor is observed to shrink temporarily by using an anticancer drug, when the risk of recurrence has not been improved, Since the phenomenon that the MV fluctuation index shows an upward trend has been clarified, more accurate diagnosis support information can be provided.

(6) By devising a vibration amount score table that lists vibration amount scores, the disease state changes of cancerous diseases can be quantified. Accordingly, it has become possible to verify cancerous diseases using numerical data in the theory of oriental medicine.

(7) By devising a vibration amount score table that lists vibration amount scores, changes in the disease state of cancerous diseases could be quantified from the five-line theory. Therefore, even in Chinese herbal medicine prescriptions based on the five elements theory, it has become possible to prescribe cancerous diseases using numerical data.

[Example 1 / MV analyzer]
The block configuration diagram shown as “1” in FIG. 1 is a block configuration diagram illustrating the functional configuration of the “MV analysis apparatus” according to the first embodiment of the present invention.

The MV analysis apparatus of the first embodiment is
A “data buffer” for receiving the MV waveform signal output from the MV detector;
A waveform signal amplification device;
(A / D) converter and noise filter;
CPU,
It consists of

The MV analysis apparatus 1 of the first embodiment shown as 1 in FIG. 1 irradiates the skin with laser light (JIS (Japanese Industrial Standards) C6802 laser safety standard laser class 1) that can irradiate the human body, for example. A laser displacement meter (SI-F01, Keyence Co., Ltd., micro head type) that can obtain the MV waveform of the skin as a measurement value based on the amplitude and time axis by reading the laser beam reflected on the skin surface. ) To measure the MV and obtain a waveform signal (data).

From the obtained waveform signals, MV waveform signals related to the center acupuncture points in each of the five regions and the marginal acupuncture points in each region are obtained, and the obtained waveform signals are amplified by the waveform signal amplification device.

This amplified waveform signal is converted into a digital signal by an (A / D) converter, the converted digital signal is input to a filtering step, and the specified frequency of the power supply from the input signal (for example, 50 Hz per second in the Kanto region) And so-called noise consisting of a frequency that is an integral multiple of F with a frequency F unique to a computing device such as a personal computer being used as a fundamental frequency.

This waveform signal from which noise has been removed is input to a CPU (arithmetic unit), and is input to a table column of spreadsheet software by a program installed in the CPU.
The numerical (digital) waveform signal for each detector is distributed and input to a table in a spreadsheet software for each column.

A step of converting the input digital data into an absolute value is added to the digital data distributed for each column, and then approximate integration is performed for each column by a program in which the waveform digital data converted into the absolute value is incorporated in spreadsheet software.

Further, the CPU calculates and obtains the logarithm of the approximately integrated MV waveform data. The obtained logarithmic value is “vibration amount logarithmic value: V”.

“Vibration amount logarithm value: V” is obtained from the left and right upper limbs and lower limbs of the body (n = 360) and each is stored with a serial number “V _n ”.

“V _n ” assigned with a serial number is input to the vibration amount score table.
This input is input to the square of the same “n” number according to the “n” number previously assigned to the vibration amount score table, and is displayed as a table.

Among the left and right sides of the body, “V _n ” on one side is n = 1 to 180.

From stored assigned the sequence number of "V _n", the value selects "V _n" of the minimum value, and "V _min".

By dividing the "V _min" from "V _n", "vibration amount logarithm: V 'obtains a difference, which," vibration amount relative value: R _n "to.

The “vibration amount relative value: R _n ” is converted into five types of symbols by three “vibration amount score parameters: (A), (B), (C)” and displayed as one piece of diagnosis support information. And provided.

The five types of symbols are
("Light red background": identification background color of the square of the table showing the maximum value), ("◎"), ("○"), ("△") and ("": blank indicating no input)
It is.

These five types of symbols are “vibration amount scores”.


[Example 2 / Biological diagnosis support apparatus]
The block configuration diagram shown as “2” in FIG. 1 is a block configuration diagram illustrating the functional configuration of the “biological diagnosis support apparatus” according to the second embodiment of the present invention.

The biodiagnosis support apparatus of the second embodiment is
A data buffer for temporarily capturing the vibration amount relative value R _n output from the MV analysis apparatus shown as “1” in FIG.
Parameter calculation and analysis device,
Hard disk drive,
Data editing area,
Diagnostic judgment area,
(2-1) Safety value file,
(2-2) Diagnostic criteria file,
(2-3) Medical diagnosis dictionary file,
(2-4) Chinese medicine diagnosis dictionary file,
(2-5) Acupuncture diagnosis dictionary file and
It is composed of a keyboard for inputting medical information such as blood test data of a subject.

The “vibration amount relative value: R _n ” output from the MV analyzer is moved to “calculation by parameter and analyzer”.
(2-1) Safety value file,
(2-2) Diagnostic criteria file,
(2-3) Medical diagnosis dictionary file,
(2-4) Chinese medicine diagnosis dictionary file,
(2-5) Acupuncture diagnosis dictionary file and
It is processed together with medical information such as blood test data of the subject inputted from the keyboard, and converted into diagnosis support information shown in the following (2) to (7).

(2) The bar graph which displayed the total result of the vibration amount score table | surface of said (1) in order to obtain | require the positional distribution pattern of a test subject's MV vibration amount.

(3) A frequency distribution table and a histogram obtained by performing statistical analysis on the total results of the vibration amount score table of (1) described above for the purpose of obtaining a statistical distribution tendency of the positional distribution pattern of the MV vibration amount of the subject.

(4) serving total value of the living micro-vibration amount of vibration was concentrated in the second region of the subject, "second region (R) sum: (R _II)".

(5) “Second region (R) concentration degree: CD” indicating the degree of concentration of the biological microvibration vibration of the subject in the second region as a ratio.

(6) “MV fluctuation index value: VD” indicating a correlation with the tumor marker value.

(7) Time-series change graph of the subject's “MV fluctuation index value: VD” and the slope of this graph.

The diagnosis support information shown in (2) to (7) is displayed by the “diagnosis support information output / display device” shown as “3” in FIG. 1 and provided as information.

In the following, the creation of a diagnostic support standard used in the biological diagnosis support apparatus of the second embodiment will be described.

[Diagnostic support standards]
The biodiagnosis support apparatus according to the present invention supports diagnosis by providing information and an index value that are significantly correlated with the progress of disease in diagnosis performed by a doctor or the like.

The diagnosis support criteria are set in advance by conducting a statistical test on subjects who are healthy Western medical subjects at the same time and who are healthy oriental medical subjects. Find the minimum value and use it as the standard area.

[Cancer disease diagnosis support criteria]
In setting a diagnostic support standard for cancerous diseases, when obtaining a safety standard value for prevention of cancerous diseases, healthy young people who are extremely unlikely to have cancerous diseases are selected.

In the diagnosis support process for cancerous diseases, subjects who can become a population for each type of cancer and for each stage of cancerous disease (scale determined by the Cancer Society on the basis of cancer progression and malignancy criteria) The reference area is determined for each stage of each cancer type using the stored data as a database.

For the definition of this reference region, the serum tumor marker value is one of the criteria.
For example, the safety standard value for the serum tumor marker CEA value in the present invention is, for example, a report on the safety standard of the serum tumor marker value related to the health risk of the contractor in the life insurance business shown in Non-Patent Document 10, etc. Establish reference values with reference to reliable research reports.

In the present invention, “experience of introducing a tumor marker in risk selection” was adopted as this research report. This was conducted by the research team of Yasuda Life Mutual Insurance Company, and is recorded in the paper information navigator [signy] managed by the National Institute of Informatics (Non-patent Document 15).

Safety standard values for serum tumor marker values should generally not conform to hospital tumor marker test standards.
For example, taking the tumor marker CEA as an example, the safety standard value for the serum tumor marker value in a general hospital is that there is no recurrence of a cancerous tumor in a patient who has undergone tumor resection due to a cancerous disease It is often used as an index for knowing.
When the MV of a patient who has undergone tumor resection for cancerous disease is analyzed once using the MV analysis apparatus of the present invention, the values of the following five items greatly deviate from the range of healthy subjects.

These items are
“Vibration amount relative value: (R)”,
“First region (R) total value: R _I ”, “second region (R) total value: R _II ”, and “third region to fifth region (R) total value: R _III-V ”,
“Second area (R) concentration: CD”,
“MV fluctuation index value: VD”,
It is.

That is, the fact that the values of the five items deviate greatly from the range of healthy subjects indicates that the so-called “cancerous constitution” of patients has not been improved even after surgery.

Therefore, since the diagnosis support information indicated by the diagnosis support apparatus of the present invention correlates with the tumor marker value, a value that is significantly lower than the general hospital test value must be determined in the safety standard setting of the diagnosis support information.

In the present invention, the average value of serum tumor marker values of 196 cases selected as healthy persons out of 279 cases (of which 17 cases are women and average age 46 years) reported by this research report is defined as the safest reference value. It was. These values are for example for the tumor marker CEA:
CEA; 0.6 ng / ml
It is.
This value, CEA; 0.6 ng / ml
Based on the above, by obtaining the safest reference value of the MV fluctuation index value and adding the obtained reference value to the database, it is possible to supplement the database for similar disease trends.

[Chinese medicine prescription support standards]
In setting the standard of diagnostic support information to be presented to doctors who prescribe Kampo medicines, the selection of the population in consideration of the doctors using these diagnostic support information for herbal medicine (see paragraph [00 75 ]) The condition of healthy Oriental medicine must be added. This is because, in the crude drug simple dictionary file, most of the effective databases related to the crude drug efficacy are traditionally created based on oriental medical criteria.

[Example 3 / Diagnosis support information presented to doctors prescribing herbal medicine]
In the biological diagnosis support apparatus of the present invention, a “Chinese medicine diagnosis dictionary file” is provided in the database in advance.
In this Chinese medicine diagnosis dictionary file, the MV distribution before the Chinese medicine administration related to the subject is compared with the MV distribution after the medicine, and a change in the MV distribution that can be considered as a medicinal effect is recorded.
Next, the process of creating this Chinese medicine diagnosis dictionary file will be described.

(1) First, the amplitude score table described in paragraphs [0100] to [0101] is created for a subject to be prescribed by a doctor or the like.

(2) Next,
(A) Which area is the area where the high amplitude value of the amplitude score table created in (1) is recorded,
(B) Which meridian is recorded with the meridian where this high-amplitude part is recorded,
And get information.

(3) Next, with reference to the list of microvibration-corresponding scores in herbal medicines and recurring cases exemplified in Tables 12 to 13, a suitable herbal medicine is selected.
The recursion mentioned in the title of this list is a characteristic defined for each herbal medicine that serves as an index when selecting a herbal simplet according to the symptoms, and has been traditionally used by those skilled in the art.

The cold score written at the left end of this list is an index that shows how the balance of heat in the body is controlled by taking a simple herbal medicine.
In the row area of the cold score, the spleen meridian was written in the upper row with the letters “spleen”, the meridian name was also written in the next row, and the small intestine meridian was written in the bottom row.

In addition, the upper side of this list, of Samunetsu symbols fill in the next line of the line of herbal medicine name, +, -, ±, and is the symbol, herbal plain is shown and described herein in the line of herbal medicine name, It describes what kind of heat change is given to the body after taking it.

For example, the “subscript” described in the fourth region section of Table 13 has a + (plus) cold symbol, and the cold value shown in the next row of the cold symbol is 4.0. . Further, when the column in which this appendix is written is traced down, it reaches the row region of the cold score, and all meridians are marked with a symbol in this region.
This fever symbol +
Means that this bud acts on the body after taking it to improve the coldness of the body,
What is a cold value of 4.0?
This appendix indicates that the degree of positive thermal action given to the body after taking is 4.0.
The statement that the cold score is ○ in all meridians
It shows that the cold phenomenon which existed in all 12 meridians is improved by taking this appendix.

On the other hand, according to Table 1 3, To exemplify "gypsum" showing, according to the right end of the second region division, Samunetsu symbol - a (negative), and described in the following line of Samunetsu symbol The cold value shown is -1.0.
Further, when the column in which this gypsum is written is traced downward, it is in the row region of the cold score, or in this region, only the heart capsule and the meridian of the heart are marked with a circle.

The description of gypsum shown in Table 1 3, using the MV analyzer of the present invention, as compared with subjects data measured before taking, the subject of the data measured after taking, from the comparison result Created.

Traditional consideration of traditional Chinese medicine has traditionally interpreted that gypsum eliminates the heat generation state inside the body or the heat unbalanced state called internal heat after taking it. It was.
For example, according to Non-Patent Document 11, there is a description indicating that doctors at the time have been discussing the prescription of this plaster since the Edo period.
The discussion centered on the fact that gypsum improved the fever that occurs in inflammatory diseases of the body, while at the same time cooling the body as a secondary effect. Since then, there has been no method for scientific analysis of the body's biological response that changes with administration in order to verify the effects of gypsum.

When the body reaction after taking gypsum was analyzed by the MV analysis device of the present invention, as shown in FIGS. In the case of subjects with a distribution, a biological reaction was found in which the distribution of this high-amplitude region disappeared by taking gypsum.

The present inventor considers this gypsum in clinical experience and the biological reaction after taking gypsum, and the second region frequently described in the specification of the present invention relates to the heat balance in the body using MV. We found that this is an important area for understanding biological reactions.
Similarly to the examples relating to the medicinal effects of this gypsum, the description of the cryogenic score relating to the herbal medicine alone shown in Tables 12 to 13 is based on the comparison between the MV vibration amount distribution data after taking and the same data before taking. It was created.

The basic concept of the cold symbol and the cold value is known by a research group devised by Dr. Kensuke Koda, who is engaged in medical care as a pharmacist in Saga Prefecture.

(4) A doctor or the like prescribes the herbal medicine derived in the steps up to the above (3) to the subject, and measures the MV vibration amount distribution of the subject again after 1 hour to 3 hours. The type of data obtained by this measurement is the same as (2) above.

(5) The data obtained in the above (2) is the pre-dose data, the data obtained in (4) is the post-dose data, the two are compared, and in the area where the high amplitude value was recorded in the pre-dose data, If there is a disappearance of high-amplitude site after taking or if it cannot disappear, find the meridian and the relative difference in the relative value of the amount of vibration (R) remaining, and take the medicinal herbs As simple medicinal effect information, it records in the list | wrist of the list | wrist of the microvibration corresponding | compatible score in the crude drug simple substance illustrated in Tables 12-13 , and memorize | stores it as a database.

In the work of confirming the efficacy of traditional Chinese medicines, there has been no means for discriminating the efficacy of the taken Chinese medicine in a short time of about 1 to 3 hours.
If the MV reaction is used using the MV analyzer of the present invention, the medicinal effects of the taken Chinese medicine can be confirmed within a relatively short time of about 1 to 3 hours after taking the medicine. It is possible to provide doctors and the like with prescription support information that enables prescription of Chinese medicine according to the disease state of each patient and individual differences more effectively for the patients inside.

[Each apparatus according to the present invention]
Each device according to the present invention will be described below.

[Vibration detector]
The vibration detection device used for inputting the MV measurement value to the MV analysis device according to the present invention includes, for example, a piezoelectric accelerometer, a servo accelerometer, a laser displacement meter using a laser beam that can irradiate the human body, and a light emitting diode. 3D displacement meter using a laser, synthetic aperture radar device using laser light that can irradiate the human body instead of microwaves,
At least one selected from the group consisting of

[Measurable frequency band of vibration detector]
The measurable frequency band of the vibration detector used in the MV analyzer according to the present invention is preferably
The frequency band from 0 to 1000 Hz can be measured.

[Measurement accuracy of vibration detector]
The measurement accuracy of the vibration detector used in the MV analyzer according to the present invention is preferably
A displacement of 1 nanometer can be measured.
[Sampling cycle of vibration detector (number of measurements per second)]
The sampling period of the vibration detection device used in the MV analysis device according to the present invention is preferably
More than 5 kilohertz.

[Filtering frequency of noise removal step]
In the MV analyzing apparatus according to the present invention, the filtering frequency of the noise removing step is at least:
The specified frequency of the power supply, that is, a frequency that is an integer multiple of 50 having a fundamental frequency of 50 Hz in the Kanto region,
as well as,
The frequency is an integer multiple of F with the frequency F unique to the computing device used as the fundamental frequency.

[Mode of measurement data processing apparatus]
For the MV waveform curve obtained by measuring the left and right sides of the subject, the product of the measurement time interval Δt and the measurement amplitude value Δd is generated to obtain an integral approximation of the area formed by the waveform curve and the time axis x. The processing device preferably comprises spreadsheet software that operates using a programming language.

The row of this spreadsheet software describes the measurement time of the MV waveform data. In the embodiment, for example, the amplitude value of the waveform obtained within the measurement time of 5 seconds is temporarily stored.
Therefore, the number of rows necessary for the table included in the spreadsheet software is, for example, at least 50,000 in the second region measurement example of FIG. 33 in which the sampling frequency is set to 5 kHz and the waveform measurement time is set to 10 seconds. A line is required. This number of rows is (number of rows needed for this table)
= (Waveform measurement time; 10 seconds) x (Sampling frequency: 5000 Hz)
Ask for.

Hereinafter, the present invention will be described with reference to the drawings.

It is a figure which shows the block configuration of a biological micro vibration analysis apparatus. It is a figure which shows the lunar lung meridian of a hand. It is a figure which shows the small intestine renal meridian of a leg | foot. It is a figure which shows the characteristic of the position of a 5th hole. It is a figure which shows the five-line hole of a limb. It is a figure which shows the positional relationship of a five-row hole and 5 area | regions (1st area | region-5th area | region). It is a figure which shows the 1st area | region of a hand. It is a figure which shows the 2nd area | region of a hand. It is a figure which shows the 2nd area | region edge acupuncture point of a hand. It is a figure which shows the 1st area | region center acupuncture point of a hand. It is a figure which shows the analyzer of the biological reaction waveform information currently disclosed by patent document 1. FIG. (The drawing was made by the applicant based on FIGS. 1 and 8 of the original document.) It is a figure which shows the micro vibration measuring apparatus currently disclosed by the nonpatent literature 4. (Drawed by the applicant based on the description of the original document.) It is a figure which shows the relationship between the microvibration of the thumb ball of a healthy adult's left hand, an electrocardiogram, and a respiration curve. (Drawed by the applicant based on the description in the original document.) It is a figure which shows the relationship between the thumb ball microvibration of a complete atrial block patient, the microvibration of the parietal, and the microvibration of the eyelid. It is a figure which shows MV amplitude value distribution (56 years old and female) in the early stage of common cold. It is a figure which shows MV amplitude value distribution (56 years old and female) after the cold is completely cured. It is a figure which shows MV amplitude value distribution (56 years old and female) from a fingertip (tree) to an elbow (water). Vibration amount relative values of male subjects (age 65) who received tumor resection surgery for colorectal cancer: a diagram showing distribution (1) of R _n. Vibration amount relative values of male subjects (age 65) who received tumor resection surgery for colorectal cancer: a diagram showing distribution (2) of R _n. Vibration amount relative values of male subjects (age 65) who received tumor resection surgery for colorectal cancer: a diagram showing distribution (3) of R _n. After esophageal cancer resection surgery, vibration amount relative values of male subjects (age 63) with a course of right subclavian lymph node metastasis: is a diagram showing distribution (1) of R _n. After esophageal cancer resection surgery, vibration amount relative values of male subjects (age 63) with a course of right subclavian lymph node metastasis: is a diagram showing distribution (2) of R _n. After esophageal cancer resection surgery, vibration amount relative values of male subjects (age 63) with a course of right subclavian lymph node metastasis: is a diagram showing distribution (3) of R _n. It is a figure which shows examination (1) regarding a tumor marker and an MV fluctuation index value. It is a figure which shows examination (2) regarding a tumor marker and an MV fluctuation index value. It is a figure which shows examination (3) regarding a tumor marker and an MV fluctuation index value. It is a figure which shows examination (4) regarding a tumor marker and an MV fluctuation index value. It is a figure which shows examination (5) regarding a tumor marker and an MV fluctuation index value. It is a figure which shows examination (6) regarding a tumor marker and an MV fluctuation index value. It is a figure which shows the histogram showing distribution of the vibration amount relative value obtained from seven healthy young people with low possibility of a cancerous disease. Histogram showing the distribution of relative vibration values obtained from 10 subjects whose cancerous diseases are clearly worsening

DESCRIPTION OF SYMBOLS 1 ... MV analysis apparatus 2 ... Biodiagnosis support apparatus 3 ... Diagnosis support information output / display apparatus HT09 ... Acupuncture point: Low impact TE01 ... Acupuncture point: Seki PC09 ... Acupuncture point: Medium impact LI01 ... Acupuncture point: Shangyang LU11 ... Acupuncture point: Shokusho PC08 ... Acupuncture point: Labor Palace HT08 ... Acupuncture point: Shofu TE02 ... Acupuncture point: Liquid gate LU10 ... Acupuncture point: Fishboard SI02 ... acupuncture points: prior valley LI02 · · · acupuncture points: two between R _I · · · first region (R) total value,
R _II ... second region (R) total value R _{III to V} ... second region to fifth region (R) total value

Claims (7)

A biological reaction waveform information analyzing apparatus that measures a biological microvibration waveform generated by a living body and obtains the measured biological microvibration waveform.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, for n-th waveform of the measured biological Microvibration at measurement site represented by a natural number in the range of 1 to n _E, as shown in Equation (1), the time t amplitude f _n ( a vibration amount (F _n ) that is an integral value obtained by integrating t) in the time range from time t _{0 to} t _E ,


Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2),


While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2),
Based on Equation (4),
Calculate the vibration relative value (R _n ) which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min ),


Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;
A biological microvibration analyzer characterized by comprising:




A biological reaction waveform information analyzing apparatus that measures a biological microvibration waveform generated by a living body and obtains the measured biological microvibration waveform.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,

A first region of the hand as a first sub-measurement site;
That is,
At least two acupuncture points as the first region central acupuncture points (first main measurement site) of the selected hand as the center;
In the area within the circle drawn as the radius, the value of 1 / 160th the subject height value,
Two points facing each other at equal distances across the center,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,

A first region of the foot as a second sub-measurement site;
That is,
As a center, at least two acupuncture points as the first region central acupuncture point (second main measurement site) of the selected foot,
In the area within the circle drawn as the radius, the value of 1 / 160th the subject height value,
Two points facing each other at equal distances across the center,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,

A second region of the hand as a third sub-measurement site,
That is,
At least two acupuncture points as the second region central acupuncture points (third main measurement site) of the selected hand as the center;
In the area in the circle drawn as the radius, 1 / 10th the subject height value,
Two points facing each other at equal distances across the center,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,

A second region of the foot as a fourth sub-measurement site;
That is,
At least two acupuncture points as the second region central acupuncture points (fourth main measurement site) of the selected foot as the center;
In the area in the circle drawn as the radius, 1 / 10th the subject height value,
Two points facing each other equidistant across the center



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,

A third region of the hand as a fifth sub-measurement site;
That is,
With at least two acupuncture points as the third region central acupuncture points (fifth main measurement site) as the center of the selected hand;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,

A third region of the foot as a sixth sub-measurement site;
That is,
As a center, at least two acupoints as the third region central acupuncture points (sixth main measurement site) of the selected foot,
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other equidistant across the center



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,

A fourth region of the hand as a seventh sub-measurement site;
That is,
At least two acupuncture points as the fourth region central acupuncture points (seventh main measurement site) of the selected hand as the center;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,

A fourth region of the foot as an eighth sub-measurement site;
That is,
At least two acupuncture points as the fourth region central acupuncture points (eighth main measurement site) of the selected foot as the center;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other equidistant across the center



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,

A fifth region of the hand as a ninth sub-measurement site;
That is,
At least two acupuncture points as the fifth region central acupuncture points (9th main measurement site) as the center of the selected hand,
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A fifth region of the foot as a tenth secondary measurement site,
That is,
As a center, at least two acupuncture points as the fifth region central acupuncture points (tenth main measurement site) of the selected foot,
In the area in the circle drawn as the radius, the value of one-fourth of the subject's height value,
Two points facing each other equidistant across the center

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, for n-th waveform of the measured biological Microvibration at measurement site represented by a natural number in the range of 1 to n _E, as shown in Equation (1), the time t amplitude f _n ( a vibration amount (F _n ) that is an integral value obtained by integrating t) in the time range from time t _{0 to} t _E ,


Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2),


While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2),
Based on Equation (4),
Calculate the vibration relative value (R _n ) which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min ),


Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;
A biological microvibration analyzer characterized by comprising:




A biodiagnosis support device for measuring a waveform of a biological microvibration generated by a living body and based on biological response waveform information obtained from the measured waveform of the biological microvibration.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, for n-th waveform of the measured biological Microvibration at measurement site represented by a natural number in the range of 1 to n _E, as shown in Equation (1), the time t amplitude f _n ( a vibration amount (F _n ) that is an integral value obtained by integrating t) in the time range from time t _{0 to} t _E ,


Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2),


While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2),
Based on Equation (4),
Calculate the vibration relative value (R _n ) which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min ),


Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;

The vibration amount relative value (R _n ) for each measurement site represented as a list obtained by the second means is expressed as follows:
Based on Equations (5) to (7),
A first region total vibration amount relative value (R _I ) as a total value of vibration amount relative values (R _n ) belonging to the first region;
Second region total vibration amount relative value (R _II ) as a total value of vibration amount relative values (R _n ) belonging to the second region,
Third and subsequent total vibration amount relative values (R _{III to V} ) as a total value of vibration amount relative values (R _n ) belonging to the third to fifth regions
A third means for calculating


The first region total vibration amount relative value (R _I ), the second region total vibration amount relative value (R _II ), and the third and subsequent region total vibration amount relative values (R _{III to} ) calculated by the third means. _V )
Based on Equation (8), a second region amplitude concentration index (CD) that is an index of the degree of concentration of biological microvibration on the second region is calculated and displayed.



And / or

Fourth means for calculating and displaying a biological microvibration fluctuation index (VD) that is an index of the magnitude of fluctuation of the biological microvibration in the entire region based on the mathematical formula (9).

A biodiagnosis support device comprising:





A biodiagnosis support device for measuring a waveform of a biological microvibration generated by a living body and based on biological response waveform information obtained from the measured waveform of the biological microvibration.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,

A first region of the hand as a first sub-measurement site;
That is,
At least two acupuncture points as the first region central acupuncture points (first main measurement site) of the selected hand as the center;
In the area within the circle drawn as the radius, the value of 1 / 160th the subject height value,
Two points facing each other at equal distances across the center,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,

A first region of the foot as a second sub-measurement site;
That is,
As a center, at least two acupuncture points as the first region central acupuncture point (second main measurement site) of the selected foot,
In the area within the circle drawn as the radius, the value of 1 / 160th the subject height value,
Two points facing each other at equal distances across the center,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,

A second region of the hand as a third sub-measurement site,
That is,
At least two acupuncture points as the second region central acupuncture points (third main measurement site) of the selected hand as the center;
In the area in the circle drawn as the radius, 1 / 10th the subject height value,
Two points facing each other at equal distances across the center,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,

A second region of the foot as a fourth sub-measurement site;
That is,
At least two acupuncture points as the second region central acupuncture points (fourth main measurement site) of the selected foot as the center;
In the area in the circle drawn as the radius, 1 / 10th the subject height value,
Two points facing each other equidistant across the center



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,

A third region of the hand as a fifth sub-measurement site;
That is,
With at least two acupuncture points as the third region central acupuncture points (fifth main measurement site) as the center of the selected hand;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,

A third region of the foot as a sixth sub-measurement site;
That is,
As a center, at least two acupoints as the third region central acupuncture points (sixth main measurement site) of the selected foot,
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other equidistant across the center



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,

A fourth region of the hand as a seventh sub-measurement site;
That is,
At least two acupuncture points as the fourth region central acupuncture points (seventh main measurement site) of the selected hand as the center;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,

A fourth region of the foot as an eighth sub-measurement site;
That is,
At least two acupuncture points as the fourth region central acupuncture points (eighth main measurement site) of the selected foot as the center;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other equidistant across the center



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,

A fifth region of the hand as a ninth sub-measurement site;
That is,
At least two acupuncture points as the fifth region central acupuncture points (9th main measurement site) as the center of the selected hand,
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A fifth region of the foot as a tenth secondary measurement site,
That is,
As a center, at least two acupuncture points as the fifth region central acupuncture points (tenth main measurement site) of the selected foot,
In the area in the circle drawn as the radius, the value of one-fourth of the subject's height value,
Two points facing each other equidistant across the center

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, for n-th waveform of the measured biological Microvibration at measurement site represented by a natural number in the range of 1 to n _E, as shown in Equation (1), the time t amplitude f _n ( a vibration amount (F _n ) that is an integral value obtained by integrating t) in the time range from time t _{0 to} t _E ,


Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2),


While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2),
Based on Equation (4),
Calculate the vibration relative value (R _n ) which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min ),


Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;

The vibration amount relative value (R _n ) for each measurement site represented as a list obtained by the second means is expressed as follows:
Based on Equations (5) to (7),
A first region total vibration amount relative value (R _I ) as a total value of vibration amount relative values (R _n ) belonging to the first region;
Second region total vibration amount relative value (R _II ) as a total value of vibration amount relative values (R _n ) belonging to the second region,
Third and subsequent total vibration amount relative values (R _{III to V} ) as a total value of vibration amount relative values (R _n ) belonging to the third to fifth regions
A third means for calculating


The first region total vibration amount relative value (R _I ), the second region total vibration amount relative value (R _II ), and the third and subsequent region total vibration amount relative values (R _{III to} ) calculated by the third means. _V )
Based on Equation (8), a second region amplitude concentration index (CD) that is an index of the degree of concentration of biological microvibration on the second region is calculated and displayed.



And / or

Fourth means for calculating and displaying a biological microvibration fluctuation index (VD) that is an index of the magnitude of fluctuation of the biological microvibration in the entire region based on the mathematical formula (9).


A biodiagnosis support device comprising:




A biodiagnosis support device for measuring a waveform of a biological microvibration generated by a living body and based on biological response waveform information obtained from the measured waveform of the biological microvibration.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, for n-th waveform of the measured biological Microvibration at measurement site represented by a natural number in the range of 1 to n _E, as shown in Equation (1), the time t amplitude f _n ( a vibration amount (F _n ) that is an integral value obtained by integrating t) in the time range from time t _{0 to} t _E ,


Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2),


While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2),
Based on Equation (4),
Calculate the vibration relative value (R _n ) which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min ),


Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;

The vibration amount relative value (R _n ) for each measurement site represented as a list obtained by the second means is expressed as follows:
Based on Equations (5) to (7),
A first region total vibration amount relative value (R _I ) as a total value of vibration amount relative values (R _n ) belonging to the first region;
Second region total vibration amount relative value (R _II ) as a total value of vibration amount relative values (R _n ) belonging to the second region,
Third and subsequent total vibration amount relative values (R _{III to V} ) as a total value of vibration amount relative values (R _n ) belonging to the third to fifth regions
A third means for calculating


The first region total vibration amount relative value (R _I ), the second region total vibration amount relative value (R _II ), and the third and subsequent region total vibration amount relative values (R _{III to} ) calculated by the third means. _V )
Based on Equation (8), a second region amplitude concentration index (CD) that is an index of the degree of concentration of biological microvibration on the second region is calculated,



A fourth means for calculating a biological microvibration fluctuation index (VD), which is an index of the magnitude of fluctuation of the biological microvibration in the entire region, based on the mathematical formula (9);


The biomicrovibration variability index (VD) value calculated by the fourth means is collated with a calibration curve based on a regression equation between the biomicrovibration variability index (VD) and the serum concentration of the serum tumor marker, Fifth means for predicting serum concentration of serum tumor marker

A biodiagnosis support device comprising:





A biodiagnosis support device for measuring a waveform of a biological microvibration generated by a living body and based on biological response waveform information obtained from the measured waveform of the biological microvibration.


The first region center acupoint of the hand as the first main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU11, LI01, PC09, TE01, HT09, SI01 of the left and right hands indicated by the WHO standard code symbol,

A first region of the hand as a first sub-measurement site;
That is,
At least two acupuncture points as the first region central acupuncture points (first main measurement site) of the selected hand as the center;
In the area within the circle drawn as the radius, the value of 1 / 160th the subject height value,
Two points facing each other at equal distances across the center,



As a second main measurement site, the first region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST45, SP1, BL67, KI1, GB44, LR1 of the left and right feet indicated by the WHO standard code symbol,

A first region of the foot as a second sub-measurement site;
That is,
As a center, at least two acupuncture points as the first region central acupuncture point (second main measurement site) of the selected foot,
In the area within the circle drawn as the radius, the value of 1 / 160th the subject height value,
Two points facing each other at equal distances across the center,



Second region central acupuncture point of the hand as a third central measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU10, LI02, PC08, TE02, HT08, SI02 of the left and right hands indicated by the WHO standard code symbol,

A second region of the hand as a third sub-measurement site,
That is,
At least two acupuncture points as the second region central acupuncture points (third main measurement site) of the selected hand as the center;
In the area in the circle drawn as the radius, 1 / 10th the subject height value,
Two points facing each other at equal distances across the center,



As the fourth main measurement site, the second region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST44, SP2, BL66, KI2, GB43, LR2 of the left and right feet indicated by the WHO standard code symbol,

A second region of the foot as a fourth sub-measurement site;
That is,
At least two acupuncture points as the second region central acupuncture points (fourth main measurement site) of the selected foot as the center;
In the area in the circle drawn as the radius, 1 / 10th the subject height value,
Two points facing each other equidistant across the center



The third region central acupuncture point of the hand as the fifth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU09, LI03, PC07, TE03, HT07, SI03 of the left and right hands indicated by the WHO standard code symbol,

A third region of the hand as a fifth sub-measurement site;
That is,
With at least two acupuncture points as the third region central acupuncture points (fifth main measurement site) as the center of the selected hand;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



The third region center acupuncture point of the foot as the sixth main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points ST43, SP3, BL65, KI3, GB41, LR3 of the left and right feet indicated by the WHO standard code symbol,

A third region of the foot as a sixth sub-measurement site;
That is,
As a center, at least two acupoints as the third region central acupuncture points (sixth main measurement site) of the selected foot,
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other equidistant across the center



4th region center acupuncture point of the hand as the seventh main measurement site,
That is, at least two acupuncture points selected from six types of acupuncture points LU07, LI05, PC05, TE06, HT04, SI05 of the left and right hands indicated by the WHO standard code symbol,

A fourth region of the hand as a seventh sub-measurement site;
That is,
At least two acupuncture points as the fourth region central acupuncture points (seventh main measurement site) of the selected hand as the center;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



As the eighth main measurement site, the fourth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST41, SP5, BL60, KI7, GB38, LR4 of the left and right feet indicated by the WHO standard code symbol,

A fourth region of the foot as an eighth sub-measurement site;
That is,
At least two acupuncture points as the fourth region central acupuncture points (eighth main measurement site) of the selected foot as the center;
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other equidistant across the center



The fifth region center acupuncture point of the hand as the ninth main measurement site,
That is, at least two acupuncture points selected from the six types of acupuncture points LU05, LI11, PC03, TE10, HT03, SI08 of the left and right hands indicated by the WHO standard code symbol,

A fifth region of the hand as a ninth sub-measurement site;
That is,
At least two acupuncture points as the fifth region central acupuncture points (9th main measurement site) as the center of the selected hand,
In the area within the circle drawn as the radius, 1 / 80th the subject height value,
Two points facing each other at equal distances across the center,



As the 10th main measurement site, the fifth region center acupuncture point of the foot,
That is, at least two acupuncture points selected from six types of acupuncture points ST36, SP9, BL40, KI6, GB33, LR8 of the left and right feet indicated by the WHO standard code symbol,

A fifth region of the foot as a tenth secondary measurement site,
That is,
As a center, at least two acupuncture points as the fifth region central acupuncture points (tenth main measurement site) of the selected foot,
In the area in the circle drawn as the radius, the value of one-fourth of the subject's height value,
Two points facing each other equidistant across the center

A total n _E locations, in each of the numbered the 1 to n _E th measurement site by the people Nojun, first means for measuring the waveform of the living micro-vibration,

By the first means, for n-th waveform of the measured biological Microvibration at measurement site represented by a natural number in the range of 1 to n _E, as shown in Equation (1), the time t amplitude f _n ( a vibration amount (F _n ) that is an integral value obtained by integrating t) in the time range from time t _{0 to} t _E ,


Calculate the vibration amount logarithmic value (V _n ) of the total n _E vibration amounts (F _n ) calculated by Equation (1) based on Equation (2),


While detecting the lowest vibration amount logarithm value (V _min ) which is the lowest value from the total n _E vibration amount logarithm values (V _n ) calculated by the equation (2),
Based on Equation (4),
Calculate the vibration relative value (R _n ) which is the difference between the total n _E vibration amount logarithmic values (V _n ) and the minimum vibration amount logarithmic value (V _min ),


Total n _E vibration amount relative values (R _n )
In the order of numbers 1 to n _E numbered in the order listed above,
A second means for representing a relative value (R _n ) of vibration amount for each measurement site as a list;

The vibration amount relative value (R _n ) for each measurement site represented as a list obtained by the second means is expressed as follows:
Based on Equations (5) to (7),
A first region total vibration amount relative value (R _I ) as a total value of vibration amount relative values (R _n ) belonging to the first region;
Second region total vibration amount relative value (R _II ) as a total value of vibration amount relative values (R _n ) belonging to the second region,
Third and subsequent total vibration amount relative values (R _{III to V} ) as a total value of vibration amount relative values (R _n ) belonging to the third to fifth regions
A third means for calculating


The first region total vibration amount relative value (R _I ), the second region total vibration amount relative value (R _II ), and the third and subsequent region total vibration amount relative values (R _{III to} ) calculated by the third means. _V )
Based on Equation (8), a second region amplitude concentration index (CD) that is an index of the degree of concentration of biological microvibration on the second region is calculated,



A fourth means for calculating a biological microvibration fluctuation index (VD), which is an index of the magnitude of fluctuation of the biological microvibration in the entire region, based on the mathematical formula (9);



The biomicrovibration variability index (VD) value calculated by the fourth means is collated with a calibration curve based on a regression equation between the biomicrovibration variability index (VD) and the serum concentration of the serum tumor marker, Fifth means for predicting serum concentration of serum tumor marker

A biodiagnosis support device comprising:




Serum tumor marker
At least one selected from the group consisting of CEA, CA15-3, CA19-9, BCA, and NCC-ST-439,
The biological diagnosis support apparatus according to claim 6 or 7.