JP4576222B2 - In vivo characteristic sensor and biological information monitoring system - Google Patents

Description

The present invention relates to an in-vivo characteristic sensor and a biological information monitoring system .

  Conventionally, when a drug is administered into the body at a medical site, when a drug to be used is determined, a kinetic model is established based on general data obtained for the drug and clinical data of the patient. Based on the model, a dosage plan is set so that the blood concentration of the drug falls within the therapeutic range, and the drug is actually administered.

  The model is corrected from the measurement of blood concentration after administration, and an appropriate administration plan is set again. The drug is administered based on the set administration plan, the blood concentration after the administration is measured, and fed back to the administration plan again to control the dose of the drug. Such a system has already been studied for practical use in a diabetes treatment system.

  For example, in this diabetes treatment system, changes in blood glucose level due to insulin administration are monitored by a glucose sensor, and the insulin dose can be controlled without directly measuring the insulin concentration.

  Here, for example, when monitoring continuous biological information in order to know an appropriate injection amount of the drug, a monitoring sensor for monitoring the biological information, a drug injection port for injecting the drug into the living body, (See Non-Patent Document 1).

Noriharu Hamada, 4 others, “Development of portable artificial islets”, Chemical Industry, December 2002, p. 60-64

  However, according to the technique described in Non-Patent Document 1, since the sensor part for monitoring is large, the sensor part and the drug injection port are composed of separate devices, and two punctures are required. For this reason, the physical burden was imposed on the patient.

  Furthermore, the fact that there are two contact portions of the living body has increased the possibility of causing infection. Therefore, from the viewpoint of the patient's QOL, it was desired to puncture once, but in order to do so, it was necessary to integrate the monitoring sensor member and the drug injection port.

The present invention provides an in-vivo characteristic sensor and a biological information monitoring system capable of solving such a conventional problem and injecting a liquid into the human body and measuring a predetermined characteristic in the human body at a time. That is the issue.

The invention according to claim 1 for solving the above problems, a cylindrical member which is liquid to be injected into the human body formed by fluidly form an internal, set at the periphery of the tubular member vignetting, in the human body A sensor member formed so as to be capable of sensing a predetermined characteristic; and a conductor provided on an outer peripheral portion of the cylindrical member and capable of transmitting a signal from the sensor member , wherein the sensor member includes the cylindrical member and It is exposed from the surface of the member formed by the sensor member and the conductor, the surface of the member has a gentle curved surface, and it is possible to simultaneously inject liquid into the human body and measure a predetermined characteristic in the human body. It is an internal characteristic sensor characterized by being,
The invention according to claim 2 is the in-vivo characteristic sensor according to claim 1, wherein the cylindrical member is formed to be puncturable.
The invention according to claim 3 is the in-vivo characteristic sensor according to claim 1 or 2, wherein the cylindrical member is formed of a porous material.
The invention according to claim 4 for solving the above-mentioned problem is characterized in that the in-vivo characteristic sensor according to any one of claims 1 to 3 is connected to the in-vivo sensor, and the conductor is transferred from the sensor member. An amplifier for amplifying a signal sent through the amplifier, a recorder for receiving and recording the signal amplified by the amplifier, and a medicine injection amount for calculating a medicine injection amount based on the signal transmitted from the recorder A biological information monitoring system comprising a control device.

  According to the present invention, since the cylindrical member, the sensor member, and the conductor are provided, the cylindrical member is inserted into the human body, so that the liquid passes through the cylindrical member and enters the human body. Injected. At the same time, predetermined characteristics in the human body are measured by the sensor member provided on the cylindrical member. Here, the measured predetermined characteristic is transmitted to the outside as a signal by the conductor. Therefore, it is possible to inject liquid into the human body and measure predetermined characteristics in the human body at one time.

  In addition, according to the present invention, the cylindrical member is formed so as to be puncturable, which is particularly suitable when the measurement target is a living body, particularly a human body.

  Furthermore, according to the present invention, since the cylindrical member is formed of a porous material, the liquid flowing through the cylindrical member is also permeated from the outer peripheral direction of the cylindrical member. It can be injected evenly. In the vicinity of the portion where the sensor member of the cylindrical member is provided, it is not necessary to be formed porous. If the vicinity of the portion of the cylindrical member where the sensor member is provided is also porous, the liquid flowing inside the cylindrical member will affect the measurement target and accurately measure the predetermined characteristics of the human body. May not be possible.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. In addition, this invention is not limited to the form described in this drawing.

[Body characteristics sensor]
FIG. 1 is a schematic view showing an in-vivo characteristic sensor according to the present invention. FIG. 2 is a perspective view showing a cross section of the in-vivo characteristic sensor according to the present invention.

  The in-vivo characteristic sensor according to the present invention is not limited as long as the object of the present invention can be achieved, that is, a predetermined characteristic in the human body can be measured. A concentration sensor that can measure the concentration, a temperature sensor that can measure the temperature of a predetermined part in the body, an enzyme sensor that can measure the type and concentration of enzymes in the body, a chemical sensor that can detect predetermined substances in the body, etc. Can be mentioned.

  The in-vivo characteristic sensor 1 according to this embodiment includes a cylindrical member 2, a sensor member 3, and a conductor 4.

[Cylinder member]
The cylindrical member 2 should just be formed so that a liquid can distribute | circulate the inside. Examples of the material constituting the cylindrical member 2 include SUS, and a porous material such as porous ceramic is preferable. In the vicinity of the portion of the cylindrical member 2 where the sensor member 3 is provided, it need not be formed porous. If the vicinity of the portion of the cylindrical member 2 where the sensor member 3 is provided is also porous, the liquid that flows through the cylindrical member 2, for example, a drug, affects the measurement target and performs measurement accurately. May not be possible.

  The cylindrical member 2 is preferably formed so as to be puncturable. As an example which forms so that puncture is possible, the example etc. in which the front-end | tip of the cylinder member 2 forms in a helical shape can be mentioned. In addition, there is no restriction | limiting in particular as a cross-sectional shape of the cylinder member 2, What is necessary is just a cross-sectional shape which does not prevent when inserting in a human body. Specific examples of the cross-sectional shape of the cylindrical member 2 include a circle, an ellipse, and a polygon.

[Sensor member]
The sensor member 3 may be any member provided on the outer peripheral portion of the cylindrical member 2 and formed so as to be able to sense predetermined characteristics in the human body. As a matter of course, it is sufficient that at least the outer surface of the sensor member 3 is formed so as to be able to sense a predetermined characteristic in the human body. Here, the sensor member 3 is preferably formed so as not to substantially protrude from the surface of the in-vivo characteristic sensor 1 when viewed as the entire in-vivo characteristic sensor 1.

  As an example of forming in this way, for example, the sensor member 3 is embedded in the outer peripheral portion of the cylindrical member 2 so that the surface of the cylindrical member 2 and the surface of the sensor member 3 are flush with each other. Can be mentioned. Further, for example, the surfaces of the sensor member 3 and the cylindrical member 2 may be processed so as to have a gentle curved surface so as not to protrude from the surface of the in-vivo characteristic sensor 1 at an acute angle.

  If the sensor member 3 is formed in this way, when the in-vivo characteristic sensor 1 is inserted into the human body, the sensor member 3 does not get caught in the body tissue of the human body, so that it can be inserted without damaging the human body. it can.

  The sensor member 3 differs depending on the object to be measured. For example, when measuring glucose in the blood of a human body, the sensor member 3 is an enzyme electrode. When measuring the amount of drug in blood, the sensor member 3 can use an ion selective electrode or the like. Furthermore, for example, when measuring theophylline (bronchodilator), the sensor member 3 is an enzyme immunosensor.

  For example, when measuring cephalosporins (antibiotics), the sensor member 3 is a microorganism sensor. In addition, an FET (field effect transistor) sensor or an optical sensor suitable for measuring predetermined characteristics of each human body can be used.

[conductor]
The conductor 4 only needs to be able to transmit a signal from the sensor member 3. The conductor 4 may be made of a known signal transmission material such as metal. For example, a film-like material can be used as the conductor 4. As shown in FIG. 2, the conductor 4 is mounted so as to sandwich the sensor member 3 provided on the outer peripheral portion of the cylindrical member 2 and substantially at the center portion with the cylindrical member 2. The shape when the conductor 4 is mounted may be a shape that does not prevent the in-vivo characteristic sensor 1 itself from being inserted into the human body, for example.

[Usage characteristic sensor usage and action]
When the in-vivo characteristic sensor 1 is used, as shown in FIG. 1, the in-vivo characteristic sensor 1 is connected to an amplifier 5, a recorder 6, and a medicine injection amount control device 7.

  The amplifier 5 amplifies a signal sent from the sensor member 3 via the conductor 4, and the amplified signal is sent to the recorder 6.

  The recorder 6 records the signal amplified by the amplifier 5, and the signal is sent to the medicine injection amount control device 7.

  The medicine injection amount control device 7 calculates the optimum medicine injection amount based on the signal transmitted from the recorder 6 and adjusts the amount of medicine injected into the cylindrical member 2 of the in-vivo characteristic sensor 1.

  First, the in-vivo characteristic sensor 1 is inserted into a predetermined part of the human body. A predetermined characteristic of the human body, for example, glucose in the blood, is measured by the sensor member 3 of the in-vivo characteristic sensor 1 inserted into the living body of the human body.

  A signal is sent from the sensor member 3 to the amplifier 5 through the conductor 4. The signal sent to the amplifier 5 is amplified by the amplifier 5. The amplified signal is sent to the recorder 6. The signal sent to the recorder 6 is recorded in the recorder 6.

  Further, the signal sent to the recorder 6 is sent to the medicine injection amount control device 7. Based on the signal sent to the drug injection amount control device 7, the drug injection amount control device 7 calculates a predetermined characteristic of the human body, for example, the amount of glucose in the blood.

  Based on the calculated predetermined characteristics of the human body, for example, the amount of glucose in the blood, the drug injection amount control device 7 calculates the optimal injection amount of the drug.

  The optimal amount of medicine is sent to the tubular member 2. The medicine sent to the cylinder member 2 is injected into the human body through the cylinder member 2.

According to this embodiment as described above, the following effects are obtained.
(1) By including the cylindrical member 2, the sensor member 3, and the conductor 4, the drug is injected through the cylindrical member 2 by inserting the cylindrical member 2 into the living body of the human body. The At the same time, a predetermined characteristic of the human body, for example, glucose in the blood, is measured by the sensor member 3 provided on the cylindrical member 2. Here, there is a possibility that a change in the predetermined characteristic of the human body due to the injected medicine varies depending on the part of the human body to be measured, and the time difference until the predetermined characteristic value of the human body becomes stable is a measurement part May occur. The glucose in the blood is measured by the sensor member 3 provided on the cylindrical member 2 while the in-vivo characteristic sensor 1 is inserted. The measured glucose in the blood is transmitted to the outside as a signal by the conductor 4. Therefore, as described above, injection of a drug into the human body and measurement of glucose in the blood in the human body can be performed with a single puncture.

(2) Since the cylindrical member 2 is formed so as to be puncturable, it is particularly suitable when the measurement object is a human body.

(3) Since the cylindrical member 2 is formed of a porous material, the drug circulating inside the cylindrical member 2 is also permeated from the outer peripheral direction of the cylindrical member 2, so that the drug is injected into the human body without any deviation. can do. In the vicinity of the portion of the cylindrical member 2 where the sensor member 3 is provided, it need not be formed porous. If the vicinity of the portion of the cylindrical member 2 where the sensor member 3 is provided is also porous, the liquid to be circulated inside the cylindrical member 2, for example, a drug affects the measurement target, for example, in blood in the human body In some cases, it is not possible to accurately measure glucose.

  It should be noted that the present invention is not limited to the above-described embodiment, and modifications and improvements within the scope that can achieve the object of the present invention are included in the present invention.

  As a first modification, for example, as shown in FIG. 3, in the in-vivo characteristic sensor 1 </ b> A, a sensor member 3 </ b> A is provided at the distal end portion of the outer peripheral portion of the cylindrical member 2. Moreover, the cylindrical member 2 is formed of a shape memory alloy, and is formed in a shape that forms an acute angle toward the tip when not in use.

  If it does in this way, in addition to said effect, for example, after inserting in-body characteristic sensor 1A in a human body, the temperature in a body will raise the temperature of sensor member 3A and cylinder member 2. As a result, the shape of the cylindrical member 2 changes from an acute angle to a shape that opens into the human body. As described above, when the cylindrical member 2 is opened in the human body, the sensor member 3A is exposed in the human body, that is, there is an advantage that the measuring member in the human body is easily contacted.

  As a second modification, for example, as shown in FIG. 4, in the in-vivo characteristic sensor 1 </ b> B, the distal end portion and the proximal end portion of the cylindrical member 2 </ b> B are formed in a shape whose diameter is reduced with respect to the central portion.

  In this way, in addition to the above effect, the proximal end portion of the cylindrical member 2B is also reduced in diameter, so that, for example, after the in-vivo characteristic sensor 1B is inserted into the human body, the proximal end of the cylindrical member 2B It is locked at the part and can be fixed inside the human body. As a result, more accurate measurement can be performed in order to reduce the fluctuation of the measurement object when measuring a certain part.

FIG. 1 is a schematic view showing an in-vivo characteristic sensor according to the present invention. FIG. 2 is a perspective view showing a cross section of the in-vivo characteristic sensor according to the present invention. FIG. 3 is a schematic diagram showing a first modification of the in-vivo characteristic sensor according to the present invention. FIG. 4 is a schematic diagram showing a second modification of the in-vivo characteristic sensor according to the present invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Body characteristic sensor 2 Cylinder member 3 Sensor member 4 Electric conductor 5 Amplifier 6 Recorder 7 Drug injection amount control apparatus 1A Body characteristic sensor 3A Sensor member 1B Body characteristic sensor 2B Tube member

Claims (4)

A cylindrical member formed so that the liquid injected into the human body can circulate inside;
Setting vignetting at the periphery of the tubular member, a sensor member formed by appreciably forming a predetermined characteristic of the human body,
A conductor provided on an outer peripheral portion of the cylindrical member and capable of transmitting a signal from the sensor member;
The sensor member is exposed from a member surface formed by the cylindrical member, the sensor member, and the conductor, and the member surface has a gentle curved surface,
An in-vivo characteristic sensor capable of simultaneously injecting a liquid into a human body and measuring a predetermined characteristic in the human body.   The in-vivo characteristic sensor according to claim 1, wherein the cylindrical member is formed to be puncturable.   The in-vivo characteristic sensor according to claim 1 or 2, wherein the cylindrical member is made of a porous material. The in-vivo characteristic sensor according to any one of claims 1 to 3,
An amplifier connected to the in-vivo sensor and amplifying a signal sent from the sensor member via the conductor;
A recorder for receiving and recording the signal amplified by the amplifier;
A biological information monitoring system comprising: a medicine injection amount control device that calculates a medicine injection amount based on a signal transmitted from the recorder.

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